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<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2D0</accession>
    <name>F7K2D0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00009"/>
    <dbReference type="EnsemblBacteria" id="EGN48242">
        <property type="protein sequence ID" value="EGN48242"/>
        <property type="gene ID" value="HMPREF0994_00009"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033JGV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207155_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="47" mass="4861" checksum="558300A0B75429E0" modified="2011-09-21" version="1">MKKIGLGIAILLFAIIISLCSSGMGLLVIGIGIVGLIFSIIGFIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2J2</accession>
    <name>F7K2J2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN48304">
        <property type="protein sequence ID" value="EGN48304"/>
        <property type="gene ID" value="HMPREF0994_00071"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2788573_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="68" mass="7686" checksum="3AF888BA7A6AB9E6" modified="2011-09-21" version="1">MSAGKKKYNRNQPEGIRAITMFCMIVFVCMSFYEVYFFVNRSISIPAETYADRYADSCIHPGHGGAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2K5</accession>
    <name>F7K2K5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250033.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00084"/>
    <dbReference type="EnsemblBacteria" id="EGN48317">
        <property type="protein sequence ID" value="EGN48317"/>
        <property type="gene ID" value="HMPREF0994_00084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675629_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="157" mass="18258" checksum="8C0D10E4CB2DDAF9" modified="2011-09-21" version="1">MEASIRRIIAEMERKDAYYKQAVQIEIISIVLLLMREYLDNTTERKSSDNQQVQAVKKIISYLREHFLERITIDELCADTGYSKFYLCHSFKKMTGNTIIQYVNFLKCQHARNLLLEGNHSVSESAALSGYNNDSYFTKTYKAVFGRLPSDDLRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2N8</accession>
    <name>F7K2N8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">HMPREF0994_00117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250066.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00117"/>
    <dbReference type="EnsemblBacteria" id="EGN42734">
        <property type="protein sequence ID" value="EGN42734"/>
        <property type="gene ID" value="HMPREF0994_00117"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.124"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_9"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="174" mass="19273" checksum="3ADEA4371BDDA1B7" modified="2011-09-21" version="1">MKKLEEYVRCIPDFPEEGVMFRDVTSVLQDADGLHLAIDTMQELIDDLEFDVVVGPESRGFIFGTPIAYNNHKPFVLIRKKGKLPCETASMEYDLEYGTAVIEIHKDAIRPGQKILIVDDLIATGGTTEAMIRLVEQLGGEVVGVVVLMELAGLKGREKLAGYRLESAICFEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2T6</accession>
    <name>F7K2T6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HMPREF0994_00165</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250114.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00165"/>
    <dbReference type="EnsemblBacteria" id="EGN41761">
        <property type="protein sequence ID" value="EGN41761"/>
        <property type="gene ID" value="HMPREF0994_00165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.175"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="21">
        <location>
            <begin position="110"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="19">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="22">
        <location>
            <begin position="298"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGN41761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="374" mass="42511" checksum="959666A508624FA4" modified="2011-09-21" version="1">MDLGDLRTQIDAVDEQIVDLYERRMDICRQVAEVKIETGKKVFDRDREKEKIAKVKSLTHTDFNKTGIGELFEQIMSMSRKLQYQLLTEKGTIGRLPFIGVDSLGDDRVRVVFQGAEGAYSQAAMHQYFGDAVNSFHVDTFRDACCAIEEGSADFAVLPIENSTAGIVNEIYDLLVEFENYIVGEQIIKIEHCLLGVPGGRIEDIRTVYSHPQSLMQSARFLSEHDWKQISLPNNAFAARKVAEEKDPSQAAIAGEYAGRVYGLEVLKKPVNQSDTNSTRFIIITNQKIFRKDAKKVSICFEIPHESGSLYHMLSHFIYNNLNMTKIESRPIEGRNWEYRFFIDFDGNLADSAVKNALRGLRDEARNMKILGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2W8</accession>
    <name>F7K2W8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250146.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00197"/>
    <dbReference type="EnsemblBacteria" id="EGN39230">
        <property type="protein sequence ID" value="EGN39230"/>
        <property type="gene ID" value="HMPREF0994_00197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="597" mass="69680" checksum="C06A1B8266C1EBF7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K323</accession>
    <name>F7K323_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250201.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00252"/>
    <dbReference type="EnsemblBacteria" id="EGN37891">
        <property type="protein sequence ID" value="EGN37891"/>
        <property type="gene ID" value="HMPREF0994_00252"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.273"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN37891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="231" mass="25497" checksum="1BC2CE9C05B6C402" modified="2011-09-21" version="1">MTEIIKAEKITKDYGKEKVLKGIKLSVCKDTFTAILGPSGSGKSTLLNVLSGMIRPDTGKVMYEDEVITDYTQAQLADWKRAEVGYVFQNYLLLNNLTAEENIRTGICPGKTPLAFDRLTRILEIDNILDKFPAQLSGGQQQRVAVARAVIKSPCLLFCDEATGSLDEANSKKVVALLHTLKTVFGVTILFTTHNEQIAHTADRALVIKDGLLYKDMMNENPISADDMVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K366</accession>
    <name>F7K366_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00295"/>
    <dbReference type="EnsemblBacteria" id="EGN33436">
        <property type="protein sequence ID" value="EGN33436"/>
        <property type="gene ID" value="HMPREF0994_00295"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452714_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="186" mass="20322" checksum="115F1C22B62AB992" modified="2011-09-21" version="1">MMNETLLGAVLLLLLGLGILVVVTDRLFTAVVYSAALSACIAFGYLLLGAPDVALAEAIIGSALTTVIYLATLKKYRIFTIRCLPGDTRKDPLFSKVLEVISRSLKDHDLEAHLIESRGNARTLLERPDTDLVAEKREDGIYLYGEADSQYLGRIREQLIKAGLDGEVRIVDTAPTRIAAYKGKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3G5</accession>
    <name>F7K3G5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33539.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359834.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00398"/>
    <dbReference type="EnsemblBacteria" id="EGN33539">
        <property type="protein sequence ID" value="EGN33539"/>
        <property type="gene ID" value="HMPREF0994_00398"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SFZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069956_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33539.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="170" mass="19096" checksum="C63DD9D81B620917" modified="2013-09-18" version="2">MAGLKVKETALLALLSAILLIGQIALGFLPNIEVVTLLIMVYSIVFRKKVFFIIYVFVLAEGLVYGFGIWWFNYLYVWSIQAVINLLFRKQKSVVFWSILSGFYGITFGALCSLPYFAIGGPSAAFAYWVSGLAYDIPHCIGNVALCLVLFRPLVYILRKSCREINVCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3U7</accession>
    <name>F7K3U7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_00526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250475.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00526"/>
    <dbReference type="EnsemblBacteria" id="EGN45530">
        <property type="protein sequence ID" value="EGN45530"/>
        <property type="gene ID" value="HMPREF0994_00526"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.575"/>
    <dbReference type="eggNOG" id="COG1868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052646_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="10">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN45530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="33559" checksum="BD32E26B3ACA5BA3" modified="2011-09-21" version="1">MIKAYDFKSPKKFTKERMSTVENLYDSFSRSLAPYLTGLLQSYCEISINGIQEMRFQEYSAELDDRSLFGLITLAPENKDYSDAPMIFEMDTSLGFFMIERLLGGAGTEYELHRDFTDIEKAMLHYLLEKITGFIGDAWGGYMDAEVTLTGLQTNPHLLQLGAAEDVVILVELGIVVNELKAKLHIVMPAPNVEELTSRFGYKFAMNRKNKDEAKAAERQKYIEKNLLDADVEMRAVLHEFYLDAQDILQLQPGDVVPIGKNMASDIQVYVEDMPCFEAKPGHTSMHKAVRISKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4B2</accession>
    <name>F7K4B2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250640.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00691"/>
    <dbReference type="EnsemblBacteria" id="EGN44040">
        <property type="protein sequence ID" value="EGN44040"/>
        <property type="gene ID" value="HMPREF0994_00691"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.748"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="35240" checksum="7F69259C1E92119F" modified="2011-09-21" version="1">MQESRLFRILYYLLDKGQATAPELAEKFEVSVRTIYRDIDAMSSAGIPIYVTTGRNGGIRFLDGHILDKTFFSSGEKQEILSAIQSLSAVQYPDIDNILRKLSAVFQTGLTDWIEIDFSRWGSAAEYENQLFIQLKQAVLEKRKIRFEYFNSSGTASIREALPQKLIYKDKAWYLHAFCLLHNDCRLFRFTRIKHLHLTETHFDAIPETDQNNSSQPQDTRPLINLELQFPPEVGFKLYDLLEDSAITQTQHGYTVNLTLPETDWIYDFLMSFGEKVTIIRPQYIKQKIIQKYEAALNHYKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4D6</accession>
    <name>F7K4D6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00715"/>
    <dbReference type="EnsemblBacteria" id="EGN44064">
        <property type="protein sequence ID" value="EGN44064"/>
        <property type="gene ID" value="HMPREF0994_00715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.774"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022800_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="86"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN44064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="649" mass="73582" checksum="3CD7EA5B4A273B75" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4J7</accession>
    <name>F7K4J7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate:ferredoxin (Flavodoxin) oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0994_00776</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250725.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00776"/>
    <dbReference type="EnsemblBacteria" id="EGN43485">
        <property type="protein sequence ID" value="EGN43485"/>
        <property type="gene ID" value="HMPREF0994_00776"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.842"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="ChEBI" id="CHEBI:15361"/>
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            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
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        <ligand>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <position position="825"/>
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        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
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        <location>
            <position position="848"/>
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    </feature>
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        <location>
            <position position="1079"/>
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        <ligand>
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        <location>
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        </location>
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            <dbReference type="EMBL" id="EGN43485.1"/>
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        </source>
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    <sequence length="1177" mass="127549" checksum="6E7CFA5F060D7C40" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K527</accession>
    <name>F7K527_9FIRM</name>
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        </submittedName>
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        <lineage>
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            <taxon>Clostridia</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43274.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="EGN43274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="35799" checksum="67E9EA2119DAB126" modified="2011-09-21" version="1">MLSEKQFSQIRTWVYRNAREIDLNVWKFHFENGKKEDVVSALSHYQNEDGGFGNALEPDNWNPASTPYVTLYALGLLQRIGMTDTSHPIYKGIFEYLSSEKDLTDYGWRFNVPENNNYPRAPWWNYSEDANKTESIGPTCGLCTFILQNMDKASSVYKKAETLAKQALDNLLTAKNFGDMGIGGYIGLIDALPSLNIGDYDMPALYSKINELVNASIERDVNKWQYYGVLPSTYIHSPQSPFYPANKEIVDQEINYLLETLPENGVWNISWTWFDNMESYGKEFIISENWWKSITAIEKLCFLKNFNAVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7K551</accession>
    <name>F7K551_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00989</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00989"/>
    <dbReference type="EnsemblBacteria" id="EGN43298">
        <property type="protein sequence ID" value="EGN43298"/>
        <property type="gene ID" value="HMPREF0994_00989"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1080"/>
    <dbReference type="eggNOG" id="ENOG503321V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195864_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="76" mass="8697" checksum="E6120A021AEF5785" modified="2011-09-21" version="1">MRTMEFKMERPGLLKEGDHVTVTEGVLPSNYYYTIDPSLAMSGNYPFREKLLAREGDVTAVIENERGFYVTVAFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5D3</accession>
    <name>F7K5D3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251011.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01062"/>
    <dbReference type="EnsemblBacteria" id="EGN43035">
        <property type="protein sequence ID" value="EGN43035"/>
        <property type="gene ID" value="HMPREF0994_01062"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1164"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084257_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="69"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="272" mass="30174" checksum="C1A0DCC0811AED95" modified="2011-09-21" version="1">MTNLEKTAECINIVGRFCGRRDINALSRQNLMESYGIPRVDLFLLFGGSIPCAAELFADAVREKIAAHYLIVGGEGHTTESLRRKMAALCPGLLTEGKSEAEVFSGYLSQKYGISPDYLETASTNCGNNVTNALELIKKEGLPHDTILLMQDASMQLRMDAGFRKYLDAHSRIINFACYQAEVIVENNALAFRDNTITGLWDMERYITLLMGEIPRLRDDSEGYGPQGKNFIAHVDIPEHVEKAYAYIKENYGDLTRTANPAYATIKGEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5I6</accession>
    <name>F7K5I6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251064.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01115"/>
    <dbReference type="EnsemblBacteria" id="EGN42877">
        <property type="protein sequence ID" value="EGN42877"/>
        <property type="gene ID" value="HMPREF0994_01115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1224"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="34151" checksum="CEF708D28B6FB133" modified="2011-09-21" version="1">MKEKKKKKISGIQKRNNLNFYLYISPWLIFFLALTVYPMIKSLSLAFTDSSFNGKGNFIGLENFLQAFTADPRFWAAFKNTICYVLMYVPLSLILSFFLGWLLSRNVKFLGFWRTVFYLPYITAGVAVTILWGWIFNGTYGVINYILSLFGIQGPNWLGDKRLALGCIVVMCLWSLGNQILIMLAGIQDIPDSYYESAKIDGAGTLRQVFSITLPLSTPTIFFNLVIGVISAFQLFNQPYILTQGGPVNSTVTVAMLIFQNAFQYGKMGYASCIAWCLFVVIMIFTGIIEVTQKKWVFYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5J1</accession>
    <name>F7K5J1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251069.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01120"/>
    <dbReference type="EnsemblBacteria" id="EGN42882">
        <property type="protein sequence ID" value="EGN42882"/>
        <property type="gene ID" value="HMPREF0994_01120"/>
    </dbReference>
    <dbReference type="GeneID" id="29725224"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1229"/>
    <dbReference type="eggNOG" id="ENOG5030FK3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743519_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="379" mass="43619" checksum="5A75156CD42A022A" modified="2011-09-21" version="1">MNLTKSIDFLLENAGPVIQYRLRKEILHDLDKTEEENLLEQIYQTPHFKLLQTYVKADGYIGNGAHSWDNWRGTVLHETPLQDGETAARLLSYYAVPKTHLLIAGFVAAMRDEDTLRKEFSYIPPEAVRYENRFRGIRSGFCLMILIYTMQAMLGYGDDDYVNPFLDISLEAFKSILPLSSLSEITKERRNGTRYGYPYIEENTSFPCQYHLTALAYTQTWRTPENIQLMADALNHYNAILSGPNPIHVKIGSKYYVPFPLNIQNSPIRPFHPDVIDSITYRRLLTEIAMLGTGERVEVIKTSIVNVENAIGSDGILKMNFDRPHNKRYSPKRIEYPTPYVDVRLEPDYKRKYALACDLTFWAVQFLYLCGAAQSNSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5U9</accession>
    <name>F7K5U9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251177.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01228"/>
    <dbReference type="EnsemblBacteria" id="EGN42475">
        <property type="protein sequence ID" value="EGN42475"/>
        <property type="gene ID" value="HMPREF0994_01228"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1341"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="63"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SPASM" evidence="6">
        <location>
            <begin position="229"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="37071" checksum="0707458249B978A4" modified="2011-09-21" version="1">MPIRIHNFAGKFGWNMRKYFPKLSSEGYLTFQFMTRGKSQKDYIEYFMNSDPVPHPNVVNLETINRCNSTCEFCTANKNAEKRPYARMEESLYYSIIDQLRDWGYKGHLTLYGNNEPWLDTRIVEFHKYAREQLPESFIFMSTNGLLLDVEKVKTIVPYVNQLIINNYCLDMKLHDNIKVIYEYVKAHPEEFKDVDILIQMRYLKEVLTNRAGSAPNKAATEKVIKETCLMPYTDMWITPGGKLGICCCDNFEVTDVGDLTKMPLKDAWNSPAYQKLRNAVKDGRQNYPFCKHCDFIDAGLRMEIVNDVLKQQKHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K673</accession>
    <name>F7K673_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251306.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01357"/>
    <dbReference type="EnsemblBacteria" id="EGN42219">
        <property type="protein sequence ID" value="EGN42219"/>
        <property type="gene ID" value="HMPREF0994_01357"/>
    </dbReference>
    <dbReference type="GeneID" id="29726148"/>
    <dbReference type="eggNOG" id="ENOG503353S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134280_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019277">
        <property type="entry name" value="DUF2304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10066">
        <property type="entry name" value="DUF2304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="16069" checksum="9EAA68E0063C60C8" modified="2011-09-21" version="1">MIPSTLRIVLIIALLFYFVILLIFLKNKTLELRYTLLWMFAGFILALLVIWPDVLRGFVKVIGIQDNMNGLFIMSFAFVIMIMMSLTSIVSRQANKIKLLVQELAIMEKRIRELESRQFSDNKDEFVDMEKRFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K686</accession>
    <name>F7K686_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251323.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01374"/>
    <dbReference type="EnsemblBacteria" id="EGN42236">
        <property type="protein sequence ID" value="EGN42236"/>
        <property type="gene ID" value="HMPREF0994_01374"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1494"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100966_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="224" mass="25148" checksum="1025CF5FE66D5294" modified="2011-09-21" version="1">MSFSDIFKKSFLEGFSSMELGFKEIMVVFLITACLAFYIFLVYRTVTRRTFYSKNFNISLAMLCLITSAIILTIQFSIVISLGMVGALSIVRFRTAIKDPMDLVFLFWSISVGIICGAGLAEVAVILSFLITIGILLLDKMPVVSTPMLMVINADSSDVEEQILTAVKKYSKYSKVKSRNMSGERLSMIIELRTKQESELIKEVNELEHMLSVSLLEHDGEATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6W1</accession>
    <name>F7K6W1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251547.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01628"/>
    <dbReference type="EnsemblBacteria" id="EGN42102">
        <property type="protein sequence ID" value="EGN42102"/>
        <property type="gene ID" value="HMPREF0994_01628"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1780"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051810_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="12344" checksum="4D3B7EC3CD0907E5" modified="2011-09-21" version="1">MNFEFMTIDTPLPPCMPFPIALTGFPVSSTAKVMYCRMLDAMLSKGQEDENGILFVCFSVTAIAAVLSRSPMTVKRSLNELETAGLIMRVRQGVGEPNRIYVLIPGKEDAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Y4</accession>
    <name>F7K6Y4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TM1586_NiRdase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251564.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01651"/>
    <dbReference type="EnsemblBacteria" id="EGN42125">
        <property type="protein sequence ID" value="EGN42125"/>
        <property type="gene ID" value="HMPREF0994_01651"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1804"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070562_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029478">
        <property type="entry name" value="TM1586_NiRdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14512">
        <property type="entry name" value="TM1586_NiRdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TM1586_NiRdase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="238" mass="26183" checksum="9849011039243599" modified="2011-09-21" version="1">MDLYTPIFTRASTRKFDPSPLPADTLSQLEAFISEVKPLLPDVKLEHRIVSGNDVKGMALPKAPHFLLISGKEHPLRNTAAGFLYQHAELWLYAHGYATRWLGGVKPKQTDPNHIIGMAFGKPTEPAVRKPEDFKRKPLSEIARGTDSRLEAARLAPSGMNGQPWYYIADGGKIHVYYKPSLGGLLGKMYNLTDLDVGISLCHLAVAGEHEGKSFRFTVNKTGFPAPPAGFVYVGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K791</accession>
    <name>F7K791_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251633.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01720"/>
    <dbReference type="EnsemblBacteria" id="EGN41686">
        <property type="protein sequence ID" value="EGN41686"/>
        <property type="gene ID" value="HMPREF0994_01720"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_4_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="130" mass="15062" checksum="B75D2B247C2E4805" modified="2011-09-21" version="1">MNPSSKNNNSDNVNSKNVNSLLCARMKERRTMLNLTLKQIAEALHITEATAQRYECGEIKNIPYEKIVMLAEILQCSPPYLLGWEYLKDLPPEVERILNYYNQLNEDGKKEAEKQLDNLTLIPKYTETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7A4</accession>
    <name>F7K7A4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251646.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01733"/>
    <dbReference type="EnsemblBacteria" id="EGN41676">
        <property type="protein sequence ID" value="EGN41676"/>
        <property type="gene ID" value="HMPREF0994_01733"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1893"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069099_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="9"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="29231" checksum="23BB290DDF429354" modified="2011-09-21" version="1">MKEEIKWCAIGDSFTYLNDHLDETDNRVKKGYLTRTCEYFSNLSVINIGMNGSSTPDWVNAELPEADLYTVLLGTNDWHGGVPLGRKEDFVQKKEGTILGNMGILISHIRQKAPNAALLVMNPVERGDFVYILDPFNNALGSYMPDQGQWLSDIAEGIYETCCEEGIPALNLHDLSGITPENVVRFKWVKTQDGYRKLPYPEYTKIPVRFGEDEYPYPEEAADFTYDGLHPSDKGNEVIASLLAAKLEELLGGRLCRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7W5</accession>
    <name>F7K7W5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">HMPREF0994_02011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251924.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02011"/>
    <dbReference type="EnsemblBacteria" id="EGN41416">
        <property type="protein sequence ID" value="EGN41416"/>
        <property type="gene ID" value="HMPREF0994_02011"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2206"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_9"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN41416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="209" mass="22889" checksum="960C8BD995F8C242" modified="2011-09-21" version="1">MAKVVIMDHPLIQHKIGYIRRIETGTKDFRQTISEIAMLICYEATRSLPLADVQITTPICDTTVKELKGKKMAIVPILRAGLGMVDGVLNLIPAAKIGHIGLYRDPETLEPVEYYCKLPADCADREVFVVDPMLATGGSSVAAIQMLKDKGCKKIHFMCIIAAPEGIAKMQELHPDVDLYVGALDERLNDHGYIVPGLGDAGDRIFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Z2</accession>
    <name>F7K8Z2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252183.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02282"/>
    <dbReference type="EnsemblBacteria" id="EGN41189">
        <property type="protein sequence ID" value="EGN41189"/>
        <property type="gene ID" value="HMPREF0994_02282"/>
    </dbReference>
    <dbReference type="GeneID" id="29724721"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2490"/>
    <dbReference type="eggNOG" id="ENOG502Z9A4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466031_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="535" mass="61243" checksum="43FE349274279694" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K993</accession>
    <name>F7K993_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252338.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02437"/>
    <dbReference type="EnsemblBacteria" id="EGN40836">
        <property type="protein sequence ID" value="EGN40836"/>
        <property type="gene ID" value="HMPREF0994_02437"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2671"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="465" mass="54037" checksum="ADD569954D883853" modified="2011-09-21" version="1">MNAENMINNGCSQRDSAEHEGYAKAHRSFHSIWKERNSAQPELLEKILYKGNLNRAYKRVKANKGAPGIDGTTVEEIGAYLKENQQTIIARIYKGKYTPDAVRRVEIPKPDGGMRKLGIPTVKDRIFQQAITQELMPIYEPLFSDNSYGYRPGRSAKDAIKRIKEYAEQGYIHAVALDISKYFDTLNHEKLLNLLRKEVKDERVIQWIKRYLKSGVMENGVVMETEEGSPQGGNISPLLANIYLNEFDQEYEKRGVKFVRYADDIVLLAKSDRGAKRLLETSTKYLEGTLKLKVNQEKSREVSVFAIRNFKFLGFTLGKNRKGIYIRVHGKSWKKMKSKLKELSSRRSVQSIRPSLEKIRVFMRGWLNYYGIADMKKRIDDLNSWLYHRIRMCIWKQWKKPKTRKRNLMKLGIPEYFAHQAANSRKKHWYVSGMGAVNRALTKERLINSGFYDLATAYQSVHVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Q5</accession>
    <name>F7K9Q5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02355"/>
    <dbReference type="EnsemblBacteria" id="EGN40754">
        <property type="protein sequence ID" value="EGN40754"/>
        <property type="gene ID" value="HMPREF0994_02355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2576"/>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_19_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="238" mass="27896" checksum="E391E1B477740822" modified="2011-09-21" version="1">MEIIQWTLPECEQESGAGYAFNANVRETSPLHTHDFYEIFYVNKGKAIHCVNGERIVVSSGAFVFIRPWDVHSYDSLNYSEFQMTSIGFTCDEAAEGFRWSQFPLSMVNVPKLPPHVMLNGAEKTEFENKLKGIESHPRGMERKRYFHSVFPFFIYILCNKIRQTETKQLQVMPPWLSELIEQMSQTENFVQGLPRLLECSSYSHEYIIRIFRKYLHMTPTEFINLRRINYAMGLVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9S3</accession>
    <name>F7K9S3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40588.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02605"/>
    <dbReference type="EnsemblBacteria" id="EGN40588">
        <property type="protein sequence ID" value="EGN40588"/>
        <property type="gene ID" value="HMPREF0994_02605"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40588.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="32468" checksum="7A67253D3A03E4A5" modified="2013-09-18" version="2">MKKRKWIYLSLTIPALALMILFIAAPLVNAIRISFFKWNGYSQNMRWYGLKNFANLFKDDLFWRATLNTFIYGFGSTLVQNVGGLAAALFLNNKFKGRNGVRVILYMPIMISAFIMGQILYYFVQAEGGVFNELLGLIGIPAVYWMKTGLSSTLMITLANSWQYMGLCMIIYLAGLQNIPSMYKEAAKLDGANRVKEFVHVTLPLLIPSITTAVVTNLIGGFKLFDAIVAMSNGGPNRKSMSLSFYISQLYFNDEKAGYASAVGIMTFFIIMIVALPVNAYLRKKEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAC1</accession>
    <name>F7KAC1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NusG_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02747"/>
    <dbReference type="EnsemblBacteria" id="EGN40356">
        <property type="protein sequence ID" value="EGN40356"/>
        <property type="gene ID" value="HMPREF0994_02747"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130936_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NusG_II" evidence="1">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="132" mass="14547" checksum="74DAFD2A80F2F515" modified="2011-09-21" version="1">MKHMFRHGIITKADFLLIAAVLIAASVIIAVRTAGRTEEGWVVVSRDGVEEERLSLKEDTRLLLRDEEGNENLLVIEKESVWIEEANCPDGLCVRQGHISHSGDSIICLPHKLVVTIEGTEKNTSGSDAMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAD8</accession>
    <name>F7KAD8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252665.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02764"/>
    <dbReference type="EnsemblBacteria" id="EGN40373">
        <property type="protein sequence ID" value="EGN40373"/>
        <property type="gene ID" value="HMPREF0994_02764"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3023"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="288" mass="31746" checksum="02240E8D85D24742" modified="2011-09-21" version="1">MSKVAIVTDSNSGITQQQAEELGISVLPMPFMIEGKTYFEGISLTQEEFYQRLKTGAAISTSQPSPENILQLWNELLKSYDEIVHIPMSSGLSGACQTALMLAQDYEGKIQVVNNQRISVTQRRSVLDAIHLADQGMDAAQIKNFLEKDKYNSSIYIMVDTLVYLKRGGRITPAAAALGTILKIKPVLQIQGEKLDAFAKARTTAQGKQIMINAIKNDLIKRFDRPLDNADMWLDVAHTNNDEAAAVFRDEVLQTFPGNESYMDHLSLSVACHIGPGALAVTCTTKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAG1</accession>
    <name>F7KAG1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisD</name>
        <name evidence="11" type="ORF">HMPREF0994_02787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252688.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02787"/>
    <dbReference type="EnsemblBacteria" id="EGN40396">
        <property type="protein sequence ID" value="EGN40396"/>
        <property type="gene ID" value="HMPREF0994_02787"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3050"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_0_9"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="429" mass="46421" checksum="CC2C73D942531CFB" modified="2011-09-21" version="1">MRTLKLSENTKKDLLNDLLKRSPNNYGQYETVVADIIAQVREKGDEAVFALTSKFDHCEITPDTLKVTKEEIEEAYAQAGNEFVEVMQKSAENIRLFHEKQLRSSWFDPRPDGTILGMKMLPIATAGVYVPGGKAAYPSSVLMNVIPAKVAGVERIIMLTPPGADGKVNPGTLAAANIAGVDEIYKAGGAQAIAAMAFGTESIPKVDKITGPGNIFVALAKKACFGYVSIDSIAGPSEILVIADETANPRYVAADLLSQAEHDELASAILITTSESTAAKVSEEIDGFLSSLSRSDTIRKSLDNYGYILIADSLDSAIDTANEIASEHLEILTKDPYSVMTKIRNAGAIFLGEYSSEPLGDYFAGPNHVLPTNGTAKFFSPLNVDDFMKKTSIISYSREALEKVHKDIELFAEREGLTAHANSIKVRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB18</accession>
    <name>F7KB18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252948.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03047"/>
    <dbReference type="EnsemblBacteria" id="EGN40224">
        <property type="protein sequence ID" value="EGN40224"/>
        <property type="gene ID" value="HMPREF0994_03047"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3328"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_19_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="181" mass="20492" checksum="2DCC23342571F75D" modified="2011-09-21" version="1">MKYNKKIRLKNNKECCLRNGNENDGQSVFENFNLTHSQTDYLLSYPDENSFDAEQESKFLKEKSESENEIEIIAVVDNVVAGTAGIEAVGTKYKVKHRAELGISVAKEFWGLGIGWALMNACIECARNAGYVQLELNVVAENTRAIAMYTRAGFVEYGRNPKGFHSRKTGFQELIYMKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBH0</accession>
    <name>F7KBH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253105.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03204"/>
    <dbReference type="EnsemblBacteria" id="EGN40034">
        <property type="protein sequence ID" value="EGN40034"/>
        <property type="gene ID" value="HMPREF0994_03204"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_12_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="311"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="564" mass="61396" checksum="E3F4DCEE53BCA552" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBJ7</accession>
    <name>F7KBJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03233"/>
    <dbReference type="EnsemblBacteria" id="EGN40063">
        <property type="protein sequence ID" value="EGN40063"/>
        <property type="gene ID" value="HMPREF0994_03233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089579_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="83"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="270" mass="30724" checksum="EFCF485B32D9DA6A" modified="2011-09-21" version="1">MGNILVLGASGFVGAAIKKRLERENTVYGTYFHSKAAYETETRMEFLDVRDPLAPAILLQKTEPEWIISSLRGEFADQLAFHRQLAKEMKKLPNSRLCYISTANVFDKDGERPHYEEDAPGAESEYGRFKVECESMLMQELGERCMILRLPMVWGRDCPRIRSLYAGAAGEGQVQVWTKLYINIATDEQIAGYVSHIVNTGAAGIFHVGTDDCIIHHELVRRIGERLHLQNISAAMEDEEKEEYMVLFSHREDIPDELKLTVEQVIEIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCF1</accession>
    <name>F7KCF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03530"/>
    <dbReference type="EnsemblBacteria" id="EGN39439">
        <property type="protein sequence ID" value="EGN39439"/>
        <property type="gene ID" value="HMPREF0994_03530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3857"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045363_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356800" evidence="2">
        <location>
            <begin position="25"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="488" mass="53318" checksum="AE7EB931B7E27BA5" modified="2011-09-21" version="1">MKKKAVSLILTGLLSVSMLAGCGAKEPTGVSESVPSQSSTDSQKETASESVSSESAAESTAVSSELIGKGAVTYDPSAPVNNGEDITITFWYDDPGPEGYQRYAQAIEDYQKIHPNVTIDVNNSLGWGDYWSKLPVAVASGTGPDLMHFHLNWYGDFIPQLAEPYPEDLAQALIQDFRGVEPMVYEGKVYTIPVGDMTGAIFYNKEMWEAAGLTEADIPATWEELRQVAKKLTKTEGDKIVVNGMDIPDGYFLLALNYQKGYNVFAEDGKHTQMNNPGALEAAQMLQGFITEDKIFAPGSGSSQERFGNKQSAMMYNWTWAGGWLEGNVGDSFEWGVFPTPVFDEETKVVDRNNPEVSAVVNAKATPENKAVAMDFLRFYFANDSYLVELANKTYTAPTKSTCMDDPSIAENAVVSTIAGYIDKTVWTGICTSGFDTTVGQILADELFIQGKDAQATLQKFDEENAKLADEALLETAERKSPLAQYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCH0</accession>
    <name>F7KCH0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253450.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03549"/>
    <dbReference type="EnsemblBacteria" id="EGN39458">
        <property type="protein sequence ID" value="EGN39458"/>
        <property type="gene ID" value="HMPREF0994_03549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="33618" checksum="1C8EB77BB348CE18" modified="2011-09-21" version="1">MIEDKTKHRIQHFVINAVFILLSICCVLPLLLILAASFTSERSLAINGYRFIPEELSFTAFTYIFKSPKQILTSYGVTIFVTVVGTFFSVIFTGMLAYTIARKDFKLSRILSFLVFFTLLFSGGMVPSYIMISKYYHLKDTVWAMMLPYIIMPWHVFLMKGFFADIPVSLVEAAKIDGSSEVNTFFKIIIPISKPAFATIGLFCAFTYWNDWWLSMLYIDNPDLTSLQYYLYRIMNNIQFLSSSIQAGNIGIDVGNLPSETARMALCLVAAGPMLIIFPFFQKYFVKGLTVGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD68</accession>
    <name>F7KD68_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03797"/>
    <dbReference type="EnsemblBacteria" id="EGN38768">
        <property type="protein sequence ID" value="EGN38768"/>
        <property type="gene ID" value="HMPREF0994_03797"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4136"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="358" mass="40607" checksum="0C4E73F7F4A6D406" modified="2011-09-21" version="1">MNIKKETATVQIRQIAERLQLSPGTVSIVLNGRGDSMRISKATQQRVQAMAKEMNYQPNMNARRLRQAAGEKASYIIAVYWCNDFLDELLGKFFQGAYLVTKNSKLNVEIVVQPYEFNELKKYRENMNSNRYNGVIIGGASEDDLSFMEAMDFNIPIILMNRQSNKFSWVSISDYESGRKCAKLFAARGHKKAGILNKKNKGRGSRLRELGFTEACEEFGIEVGTEWTGVAEKRNFESGYQEIKKFFMAQKDTPTALFVMDNGLIGGVLMALKENNIRVPEDMEIIVSGDDEALEYTTPTVTSLRMPMLDMAKSALEMMLTMIENNISIPMNRILVPDFIIRQSCGDFPELEDSVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDQ9</accession>
    <name>F7KDQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN38484">
        <property type="protein sequence ID" value="EGN38484"/>
        <property type="gene ID" value="HMPREF0994_03984"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2023724_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="122" mass="13221" checksum="33F1CCFD1AAB77B3" modified="2011-09-21" version="1">MAGEEDLVAFHVPYVDVGKGYVGFFQGSIRIYVGAVVLDARVDEEYIAFFDGIPFSVQHKVALPGEYQGDFYEVVAMGEFGFLSGQLAGEKERGVEVVVGDVVLYFAHDVGHLPGGGGLGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDU5</accession>
    <name>F7KDU5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">OMP decarboxylase</fullName>
            <shortName evidence="4">OMPDCase</shortName>
            <shortName evidence="4">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrF</name>
        <name evidence="6" type="ORF">HMPREF0994_04024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253925.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04024"/>
    <dbReference type="EnsemblBacteria" id="EGN37713">
        <property type="protein sequence ID" value="EGN37713"/>
        <property type="gene ID" value="HMPREF0994_04024"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4386"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060704_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN37713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="33407" checksum="1DE06442201CFF47" modified="2011-09-21" version="1">MINKLVEKIKKTNAPIVVGLDPMMKYIPEHILKQAFDAYGETLKGAGEALWQYNKGIVDAVYDLIPAVKPQIAMYEQFGIEGMIAYQKTVDYCKEKGLVVIGDIKRGDIGSTSEAYAVGHLGRAQVGSHSFEGFGEDFATVNPYLGSDGVKPFIDVCKKEKKGIFVLVKTSNPSSGEFQDRLVDGRPLYELVGEKVAQWGEEAMGEDYSYVGAVAGATYPEMGAVLRKIMPKSYILVPGYGAQGGKGADLLPFFNEDGLGAIVNSSRGIIAAYQQEKYAHFTEANYADASRQAVLDMIEDIGTALGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE08</accession>
    <name>F7KE08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37123.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN37123">
        <property type="protein sequence ID" value="EGN37123"/>
        <property type="gene ID" value="HMPREF0994_04087"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3136933_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37123.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="49" mass="5801" checksum="6E36805DA98ED42F" modified="2013-09-18" version="2">MEETGKVSEQLRQKIVDQHDYEILSKWLKLAAKAETIEEFERRIAPDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE65</accession>
    <name>F7KE65_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254045.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04144"/>
    <dbReference type="EnsemblBacteria" id="EGN36937">
        <property type="protein sequence ID" value="EGN36937"/>
        <property type="gene ID" value="HMPREF0994_04144"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4516"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="175" mass="19876" checksum="12F51472A904EA6C" modified="2011-09-21" version="1">MNQQKIGSFLKELRKEKGLTQEQFSEIMNVSGRTVSRWETGSNMPDLDILVMISEYYNVELKELLNGERESGKMDKDMKETVLKAADYSNDEKMRMMKKLHIFAWIGVISFVAFLILEGTGLADKGITGNIADFCEGVSFGMLITAVIYTSNIIYKINAVKKRIYGQNHTIGRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE70</accession>
    <name>F7KE70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">HMPREF0994_04149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254050.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04149"/>
    <dbReference type="EnsemblBacteria" id="EGN36942">
        <property type="protein sequence ID" value="EGN36942"/>
        <property type="gene ID" value="HMPREF0994_04149"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4522"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_4_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN36942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="68" mass="7585" checksum="94A81A6ED6C30749" modified="2011-09-21" version="1">MKEGLHPAFYQATVTCNCGNTFVTGSTKPEIHVEVCSKCHSFYTGQQKAAQARGRIDKFNKKYGVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE94</accession>
    <name>F7KE94_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254074.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04173"/>
    <dbReference type="EnsemblBacteria" id="EGN36966">
        <property type="protein sequence ID" value="EGN36966"/>
        <property type="gene ID" value="HMPREF0994_04173"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4550"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_10_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="53"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="177" mass="19324" checksum="2B06129034A8723D" modified="2011-09-21" version="1">MSWEIEFLNSIQHLLRNEFLDAVMPFISSLGNAGIFWILLTVVLLIIPKTRKAGVASAIALVLMLVTGNMILKPLIARLRPFTVNTAIELLIPPPSDFSFPSGHTFASFASATAILKNNRRLGIPAIILAVLIAFSRLYLYVHYPTDVFFGLLLGILAGLIGNFAAGKLSSRLHLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEF9</accession>
    <name>F7KEF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254142.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04241"/>
    <dbReference type="EnsemblBacteria" id="EGN36521">
        <property type="protein sequence ID" value="EGN36521"/>
        <property type="gene ID" value="HMPREF0994_04241"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4631"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019175_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="623"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN36521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="727" mass="83852" checksum="F745AD132851BD39" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEQ2</accession>
    <name>F7KEQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254232.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04331"/>
    <dbReference type="EnsemblBacteria" id="EGN35641">
        <property type="protein sequence ID" value="EGN35641"/>
        <property type="gene ID" value="HMPREF0994_04331"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4729"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="166"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="312"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="336"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="411" mass="45969" checksum="587A4AB2F411FA82" modified="2011-09-21" version="1">MFVMYNADTMKVPVRVWLKEEKDLEKGGMEQAYHLSRLPFLHKWVSLMPDTHTGMGMPIGGVIAAKGVVIPNAVGVDIGCGMAYTETNIRVEDIRNVMTGNGSLIQAIVGDIMRNIPVGFAHHKTEMPCYTLDVAFEEMDRYEEDAELLGQLEAGYFQIGTLGGGNHFIELQEDDNGYLAVMLHSGSRHFGKSVCDYFHAKARELNQKWYSQVPDEYRLAFLPVDTKEGAHYLNWMQLSMDFAKENREKMMLAVKAILEKWIGKYTDLTLEFSGDINCHHNYAALENHYGENVWVHRKGAVRARNGELAVIPGAMGSYSYVVMGKGNPESFCSSSHGAGRQYSRKGAMAAFTCEEVMLDLQKQGVILGKKGKADVAEESRFAYKNIEDVMDNQTDLVVPVKRLKTIGVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEV2</accession>
    <name>F7KEV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254289.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04388"/>
    <dbReference type="EnsemblBacteria" id="EGN35698">
        <property type="protein sequence ID" value="EGN35698"/>
        <property type="gene ID" value="HMPREF0994_04388"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4787"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="31555" checksum="4EE37F1242187B28" modified="2011-09-21" version="1">MNKKRKSAVEKIILYLLLSVIGLVTLFPFIWMISSSLKTETEMFVFPIQWIPEVFHWENYEKAWKMTSFPLALFNSLKVSVIITLGQVLTSAMAGYAFAKIKFRGRNKVFIGYLATMMVPFQVVMIPQFILFRKIGLINNHLALILPGIFTVFGVFMLKQFFMGIPDEILEAARIDGCSEAGIMFRVVIPLSKAALSSLAIFTFRWQWNDYLAPLIYLNDKELFTIPLALSTFRMENLTLYTLIMAGSVISLIPVILVFLFTQKYLIQGIAMTGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEW7</accession>
    <name>F7KEW7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254304.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04403"/>
    <dbReference type="EnsemblBacteria" id="EGN35713">
        <property type="protein sequence ID" value="EGN35713"/>
        <property type="gene ID" value="HMPREF0994_04403"/>
    </dbReference>
    <dbReference type="GeneID" id="29725858"/>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="250"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="348" mass="40632" checksum="EE0E674109D31AB8" modified="2011-09-21" version="1">MDMETWFAPAIELGQLVKEYREAAPGEKQRLEWQIRNSDYLSRLHILQSYSGAGFLQGLLPEEKINVIRKDFFMNPATPSPQPEGERHYQMPYHRHDYLELIFVLRGKYVQSINGVLHELKAGEVCMLNPNVIHRDEISGMEDRVLFMGLSSGFLKGELTRFFAPHPEIAAFMENQYGRTDQQYIWFGRNDFAPVQALLEQIVEEDERKLPGHHLVIKGYLVRLFGLLAENHNYICHYQSRSEIEENLVAEILKYMEDHLADVDRTGLAAFFHFNPDYLNRFLVRMTGENYSSNLRRIRLQRAAEELKHTDKSVNDIIHGLGFSNKGHFNRMFSEMYGMLPGAYRKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF47</accession>
    <name>F7KF47_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="4" type="ORF">HMPREF0994_04489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254390.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04489"/>
    <dbReference type="EnsemblBacteria" id="EGN35799">
        <property type="protein sequence ID" value="EGN35799"/>
        <property type="gene ID" value="HMPREF0994_04489"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4901"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_9"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="25612" checksum="258A249C0F1A9F56" modified="2011-09-21" version="1">MNSKTITREQLCGMFDHTCLKPFADRKMLEELCRQAKDGRFAMVAINSAPVSFCSKLLKGTGVHVGAAISFPLGQTTIETKVFETQKAIEDGADEIDYVINIGELKNGNYSYIKKEMESIVKVCRDGNVLCKVIFENCYLTREEIKKTAEIAKEAGPDFIKTSTGFGTSGADASDVRLMKETVGDHVKVKAAGGIRSWEVCRQMIDAGAERIGTSSSLEILKEFDMERASADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFE8</accession>
    <name>F7KFE8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">HMPREF0994_04577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254478.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04577"/>
    <dbReference type="EnsemblBacteria" id="EGN35346">
        <property type="protein sequence ID" value="EGN35346"/>
        <property type="gene ID" value="HMPREF0994_04577"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4996"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_3_0_9"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="31370" checksum="DED669ED8AB06A4C" modified="2011-09-21" version="1">MQINFTKMQGCGNDYVYINGFTEIIPQQQKPDFVRKMSDRHFGIGGDGVIFVNPSQTADFEMEMYNADGTRAEMCGNGIRCVGKFVYDKGLTDKKDIRVESFGKVKYLQLLTEGGTVKNVRVNMGEPILKAEEVPVVCDKEQAVSEPVVVEGKTYEMTCVSMGNPHAVVYMEDVAGLAIEKIGPFFENHPRFPRRVNTEFVKVLDKNTVEMRVWERGTGETLACGTGCCAVAVACVLNGLTGRKVTVKVLGGQLDIEWEERTNLVYMTGPAVTVFEGSVDFSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFV2</accession>
    <name>F7KFV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34657.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360150.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04731"/>
    <dbReference type="EnsemblBacteria" id="EGN34657">
        <property type="protein sequence ID" value="EGN34657"/>
        <property type="gene ID" value="HMPREF0994_04731"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34657.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="33728" checksum="DA25A90604BF7EA4" modified="2013-09-18" version="2">METKKIKAGREDRIFNITVTVISLVVLVIVLYPLYFVIIASISSPEDISLGKVRFLPSGINFAAYKFVLEEWKIWRGYLNTIFYTFFGTLLGTSVTLMAAFALSRKDLFGRNVITKLFVFTMFFSGGLIPTYMVVSSLHMVNTRTVLVVMGTVTVYNMIIARTFFQNSLPEELFEAAELDGCGVGKFFFKIALPCSKAIIAVIALYVGVSQWNSYFTAMIYVTDQKIYPLQLVLRDILILGQQLTQITDPAEIEALVERQKVAQIIKYVVIIVSSLPVICVYPFLQKYFVKGVMIGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG41</accession>
    <name>F7KG41_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254721.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04820"/>
    <dbReference type="EnsemblBacteria" id="EGN34447">
        <property type="protein sequence ID" value="EGN34447"/>
        <property type="gene ID" value="HMPREF0994_04820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5261"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057823_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="204" mass="23512" checksum="07644DD7676B1E7A" modified="2011-09-21" version="1">MNDKYASQTLNYYNQNAPQFSSSTQSLDFAPIQNKFLSFLPPQAHILDFGCGSGRDTKYFLAHGYHTDAIDGSEELCRIASEYTGVPVKQMLFQELNAAEEYDGIWACSSILHSTYYELKDILKKLACALKKEGILYASFKYGDFEGMRNGRYFIDLEEGKLQKILQETNVFELKEKWISTDIRPGRDEEKWMNIILIKKSCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGC9</accession>
    <name>F7KGC9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araA</name>
        <name evidence="8" type="ORF">HMPREF0994_04908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254809.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04908"/>
    <dbReference type="EnsemblBacteria" id="EGN34198">
        <property type="protein sequence ID" value="EGN34198"/>
        <property type="gene ID" value="HMPREF0994_04908"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5358"/>
    <dbReference type="eggNOG" id="COG2160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045663_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="366"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="498" mass="55732" checksum="E1C762253270C4ED" modified="2011-09-21" version="1">MKTGRDYKFWFCTGSQDLYGEECLRKVAEHSAKIVEGLNASGRLPFEVVLKPTLIDPATIRRTLNEANEDGECAGVITWMHTFSPAKMWILGLKEYRKPLCHLHTQFNEEIPYDTIDMDFMNENQSAHGDREFGHMVSRMGMERKIIVGHWANAEVQEKIGSWMRTAIGIMESSHIRVCRIGDNMNNVAVTEGDKVEAEVKFGWEIDHYCVNDAVEYVNAVSEGDVNALVEEYYSKYQILLEGRDPEEFRAHVAAQAKIEIGLEKFLEDGDYHAIVTHFGMLGGLQQLPGLAIQRLMEKGYGFGGEGDWKTAAMVRLMKIMAAGVPGAKGTSFMEDYTYNLVPGKEGILQAHMLEVCPSIAEGPISIKVQPLSMGNREDPARLVFTSKTGPAVATSLVDLGNRFRLIINAVDCKKCEKEMPKLPVATAFWTPQPDLATGAQAWILAGGAHHTAFSYDLTVDQMVDWAAAMGIESVVIDKDTTIRNFKNELRWNSIYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGD6</accession>
    <name>F7KGD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254816.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04915"/>
    <dbReference type="EnsemblBacteria" id="EGN34205">
        <property type="protein sequence ID" value="EGN34205"/>
        <property type="gene ID" value="HMPREF0994_04915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5369"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="348" mass="38229" checksum="0754CEBE1AC018EE" modified="2011-09-21" version="1">MDIHTIIAMGRQTGCSDIHLSEGLPMLIRVKGTLVYAPVQPGEEETRQMILQMPDAWLQKEFSEGRDVDFAIQSPDGGRERVNIFRQQGKLACTIRLLNDRIPTIEELQLPPILKQLADEPRGLILVTGPTGSGKSTTLAAMIDYVNASRPEHIITIEDPIEYMYERKQALIHQREVGRDVSSFAAALRSALREDPDIILVGEMRDYETISAALTAAETGHLVLSTLHTTGAAQTIDRIIDACPASSQNQVRIQLSGVLKGIITQCLIPTADGRGRTAATELLTGTDAVMNLIRESKGHQMSTIMQSGAANGMHTLNGDLARLVSLGMITRENAYKYSNDKRDLINYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGE5</accession>
    <name>F7KGE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04924"/>
    <dbReference type="EnsemblBacteria" id="EGN34214">
        <property type="protein sequence ID" value="EGN34214"/>
        <property type="gene ID" value="HMPREF0994_04924"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033N9Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193596_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="232" mass="25937" checksum="FC7CC88984357D74" modified="2011-09-21" version="1">MWIWKKLRNKKGFTLIELIVTFVLIGIFMVSATAVMSSFMHVFARVKSISSAQNVADVLLTKAAGELSGGQGGVFSPEKDDEEKLAEEYSLYIYQSQASGGSRHDIAVFRNEEGIQVTMGMLGDIILSPSDRAGLDENAVMDQMLLLRYCTKAIDPVTGDKNTEYTNWYYGKPSYMGTVLTEFKIEKVEEDKNLIRITVTLENAKTHFSPLTVGRIVKCRNMEAQNINVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGM6</accession>
    <name>F7KGM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254906.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05005"/>
    <dbReference type="EnsemblBacteria" id="EGN33800">
        <property type="protein sequence ID" value="EGN33800"/>
        <property type="gene ID" value="HMPREF0994_05005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5467"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="34480" checksum="2F06959300FD0845" modified="2011-09-21" version="1">MNKMERLRVNWKKNWQLHLMLFPGILLILLFKYVPLSGILIAFKDFIPRKGIFGSPWVGMENFEYMFSLPDTMRVLWNTLKIAVLKIAINFPIPIIIAILLNEVKSRKFKKSVQTIIYLPYFISWVILSGMILDIFSLDGVVNQLLGNFGVNPIFFMGDKKPFLGLLIGTDVWKNFGYGTVVYLAAITGVDESLYESAKIDGASRWKQILYITLPSIAPIVMLMMILNLGNILNAGFEQVFTLYSPRVYETADIIDTFVYRISLVEANYSLGTAVGLLKSVVSFLLIVSSYKLANKYSDYTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH29</accession>
    <name>F7KH29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002570387.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05165"/>
    <dbReference type="EnsemblBacteria" id="EGN33198">
        <property type="protein sequence ID" value="EGN33198"/>
        <property type="gene ID" value="HMPREF0994_05165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5645"/>
    <dbReference type="eggNOG" id="ENOG5032RP2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183802_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="73" mass="8049" checksum="D486B8B5DD826685" modified="2011-09-21" version="1">MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLVVSLVAVGLVFNADGVKDILLELFNKIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH73</accession>
    <name>F7KH73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0167 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862360.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05209"/>
    <dbReference type="EnsemblBacteria" id="EGN33242">
        <property type="protein sequence ID" value="EGN33242"/>
        <property type="gene ID" value="HMPREF0994_05209"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5687"/>
    <dbReference type="eggNOG" id="COG3196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983228_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005363">
        <property type="entry name" value="UPF0167"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03691">
        <property type="entry name" value="UPF0167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="287" mass="33095" checksum="4679B521C2A1268D" modified="2011-09-21" version="1">MTEYQKTYIELKKQFVATNEGPDSVRALYTFKEELEQSEDQQAKEVLVDVYDLLDFKKDAYELLCQIGNRSDKKTLKRLGTLKDYAENWGNHYALPKPKTPEEKQKEKERQAQLGLPAFRYHPNPLETGAFEESADGVVCDCCGKTTHIFYTNPFFSVEDIAYLCPECIANGEAARKYDGSFQDDFSVDDGVDDPEKLDELIHRTPGYSGWQQEYWRAHCGDYCAYLGNVGARELRALGVLEEVLDDPMWDDEQKEMIRESVNGGHLQCYLFQCLHCGKHLVWMDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHK4</accession>
    <name>F7KHK4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255176.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05333"/>
    <dbReference type="EnsemblBacteria" id="EGN32774">
        <property type="protein sequence ID" value="EGN32774"/>
        <property type="gene ID" value="HMPREF0994_05333"/>
    </dbReference>
    <dbReference type="GeneID" id="29727025"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5824"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="334" mass="38752" checksum="82CD5F5B7E5BEAB1" modified="2011-09-21" version="1">MVQKKENLRRMLEGQPHEHIPVSFFQHLKPEELHGEACVKAHIRFYKQTDPDFLKIMHDGLTAPVDLGLTSLEELKAYRPIKGRNPYIREYLERALRINESLADETDTYSNIFSPFTLLRRIGDDRLLGFLREDPQAMKDALLFMGEDLAYLSEKLIQEAGCLGIFLAMQGAETGLFTPEEFADYIAPSEQLVLSAAQESSSYNILHFCGWNQIKNQLELWRDYPGNTVNWAVYVEQLPLAEGRKYFGMRNCMGGFDNRRGKLLYSGTKEEIRRETKNILETYKNAFGSTDGLILGADCSFLTDFETERFCWVTEALRQWERERKERRTEFRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHL3</accession>
    <name>F7KHL3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255185.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05342"/>
    <dbReference type="EnsemblBacteria" id="EGN32783">
        <property type="protein sequence ID" value="EGN32783"/>
        <property type="gene ID" value="HMPREF0994_05342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="339" mass="37314" checksum="3ACCD0DBCD6E4357" modified="2011-09-21" version="1">MSVTIRDVAKAAQTSAATVSKVMNGSGSISQATIDRVEQAMRDLGYHPNARARNFARQSTKMVLFLTTLGKNAGFSNPHMFEMMSGMEEALAKKGYLLCVKSITAEEACGFVEKIFDSKEADGVVLHASIISPAMDELVAAREIPHIVIGIPDFPSHFSWIDIDNRLGGELAARYLLQCGYCSLAFLGGRQEDRISGHRLEGVLSVLNEHDVLIPGGHLRRGASDCDSGYAMTEELLSQKERPDAIICANNYIAYGCVMALKEHGEVIPEDIGVIAFDEYPLSRILKPMLTVVDIDVFDMGYQTGKCILSKIRKPNLTVRYYSTLPSVLERESTRKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHR9</accession>
    <name>F7KHR9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255251.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05408"/>
    <dbReference type="EnsemblBacteria" id="EGN32849">
        <property type="protein sequence ID" value="EGN32849"/>
        <property type="gene ID" value="HMPREF0994_05408"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5911"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="172" mass="18942" checksum="F694D4474D10EA96" modified="2011-09-21" version="1">MNETLKTLMERRSVRSYKEEQVPEDILQQILEAGEYAPSGMGMQSAVMVVVRDKDTINQISRMNAAVMGNDGDPFYGAPTVVIVFGDSTRGTYVEDGSLVMGNLMNAAASLGVDSCWIHRAKEVFLSEEGKTLMKKWGLGEEYVGIGNCILGYSNEPHPQAKARKDGYIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI13</accession>
    <name>F7KI13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32956.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571032.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05515"/>
    <dbReference type="EnsemblBacteria" id="EGN32956">
        <property type="protein sequence ID" value="EGN32956"/>
        <property type="gene ID" value="HMPREF0994_05515"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8SX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1203099_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32956.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="227" mass="26496" checksum="9C1DEF24E1F1CFF8" modified="2013-09-18" version="2">MSILITFIKLLAVFDLLVIAAYFGRDILSTVWSKFRKKPRREEPFDFSLDAAAVPLSIDSIRQLYSGDAADFVEERLLPNAAQTMAVLTDREQTAARLLLSALVGFLAEEAPMDERSFPMVMELLNCMECEKEDGCQDPVDILFEETVRRTCRHEEYYSNYQRYRLMQVDKTRVILACRILINDLLGKLYRYDYRFGYDLLLDEENSIEKKLHTSVREEWEDEDDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI22</accession>
    <name>F7KI22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571025.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05524"/>
    <dbReference type="EnsemblBacteria" id="EGN32965">
        <property type="protein sequence ID" value="EGN32965"/>
        <property type="gene ID" value="HMPREF0994_05524"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6037"/>
    <dbReference type="eggNOG" id="ENOG502Z81B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076354_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045798">
        <property type="entry name" value="TrbL_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19478">
        <property type="entry name" value="TrbL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="31759" checksum="67DC4BE0476A446D" modified="2011-09-21" version="1">MDFLLDALTEWLKEMLVGGIMGNLSGMFDSVNQQVGDISVQVGQTPQGWNGGIFNMIQNLSNSIMVPIAGVILAIVMTLELIQMITDKNNLHDVDTWMIFKWVFKSAAAILLVTNTWNIVMGVFDMAQSVVAQASGIISSDAAIDISSVLTDMEPRLMEMDLGPLFGLWFQSMFIGVTMWALYICIFIVIYGRMIEIYLVTSVAPIPMAAMMGKEWGGMGQNYLRSLLALGFQAFLIIVCVAIYAVLVQGIATEEDVIMAIWSCVGYTVLLCFTLFKTGSLAKAVFQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIA4</accession>
    <name>F7KIA4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255390.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05583"/>
    <dbReference type="EnsemblBacteria" id="EGN32408">
        <property type="protein sequence ID" value="EGN32408"/>
        <property type="gene ID" value="HMPREF0994_05583"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6100"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363791" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="380"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="516" mass="57785" checksum="BE96365BF97FE64B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIJ6</accession>
    <name>F7KIJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YhcG_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05675"/>
    <dbReference type="EnsemblBacteria" id="EGN32164">
        <property type="protein sequence ID" value="EGN32164"/>
        <property type="gene ID" value="HMPREF0994_05675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6201"/>
    <dbReference type="eggNOG" id="COG4804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046640_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="130" mass="15348" checksum="CE46BCFF4B67E149" modified="2011-09-21" version="1">MQMMYFTFIDEEFRVQVGGEDYKIDLLFFHRGLQCLVAFELKIGKFKPEYISKMDFYLEALDRQKKKENENPSVGMILCASKDDEVVEYAMSRTLSPMMVAEYQLQLPDKNVLQNKLQELINMPLLEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIP9</accession>
    <name>F7KIP9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05736"/>
    <dbReference type="EnsemblBacteria" id="EGN32225">
        <property type="protein sequence ID" value="EGN32225"/>
        <property type="gene ID" value="HMPREF0994_05736"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="321"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="427" mass="49979" checksum="BA4F35DDA5BC3185" modified="2011-09-21" version="1">MNILLVDDEVAVIQILKKAVCWEELGINEVFTAYNAQEAKRIVTQESIQIIISDIEMPQENGISFLTWVQEEYPDIVNIILTGFPDFNYAKDAISIGVFKFLLKPIVFKELKAVVEEAVQNIREEQKREEQRRYGEYYEENRGKTEKIFYRDLLSEEILPFADYMDKEIVRRGMQKEDLELDNLVLLPLTGKESKADKGSVFYFALENIAEELFPETVMLEYNGDMIWLVKKGKQKEDIEEMSRVFLGKVSRYLKYELYAYYTKDLRLEEAAQRYRMLKEVSRQYFRKGQRIYYGDPWTGSIMEEALSGNGRSGAGNELIRSLREYLEQHYNESINRKDVEELVHMNQDYLNRSFKCATGYTLMEYVQHFRILKAKEYLADMQKSISEIGGLVGYESPPYFSKIFKKCTGITPAEYRSSLSESGRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIV0</accession>
    <name>F7KIV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007037035.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05779"/>
    <dbReference type="EnsemblBacteria" id="EGN31855">
        <property type="protein sequence ID" value="EGN31855"/>
        <property type="gene ID" value="HMPREF0994_05779"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6320"/>
    <dbReference type="eggNOG" id="ENOG502Z93C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129326_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="158" mass="17601" checksum="3A380EE5F2D56C28" modified="2011-09-21" version="1">MQDEVNEKTIALYIKTGKLTAQTLQKAMKAILSKGKKQLAKPPQGKQSLKQLMKQNAGVSNIEITEGNIKAFESTAKKYGIDFALKKDATESPPRYLVFFKGRDADVLTAAFKEFSAKKLTQEKKPSIRKLLSTLKEAAQGRNAERAKVKNKDREVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ06</accession>
    <name>F7KJ06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255611.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05835"/>
    <dbReference type="EnsemblBacteria" id="EGN31463">
        <property type="protein sequence ID" value="EGN31463"/>
        <property type="gene ID" value="HMPREF0994_05835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6385"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364103" evidence="2">
        <location>
            <begin position="27"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="564" mass="62215" checksum="F6EBFB1090B24223" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ74</accession>
    <name>F7KJ74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein cas8c/csd1, subtype I-c/dvulg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000016">
        <property type="protein sequence ID" value="EGN31534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255682.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05906"/>
    <dbReference type="EnsemblBacteria" id="EGN31534">
        <property type="protein sequence ID" value="EGN31534"/>
        <property type="gene ID" value="HMPREF0994_05906"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6464"/>
    <dbReference type="eggNOG" id="ENOG502Z7WH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031037_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010144">
        <property type="entry name" value="CRISPR-assoc_prot_Csd1-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09709">
        <property type="entry name" value="Cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01863">
        <property type="entry name" value="cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="592" mass="66723" checksum="B20945094D87BBA4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJI9</accession>
    <name>F7KJI9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255799.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06023"/>
    <dbReference type="EnsemblBacteria" id="EGN31377">
        <property type="protein sequence ID" value="EGN31377"/>
        <property type="gene ID" value="HMPREF0994_06023"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6594"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="307"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="45259" checksum="DF3F0CA46EAE653C" modified="2011-09-21" version="1">MYRLLIVDDEPMIVEGLKAYILTADYSFSAVDTASNGREALEQMEKQPPDMLITDIRMPQLDGIGLLSAVREREWGTKVIVLSGYNDFEYVRSMAVLGIENYLLKPVNEEELYATVSATLKKLDNEQALQMKEQLNADLIRENIINRWLYGSIGENELIERAEFLDFTLEAACYQPCIIRLLGTNADKDPALLRRFQELCRQILSRNSSCYYARNYAGDIIAVYCPDETDSPEDSFSILLNQCLETVKNELPVSPYVLLGSCVENYWEVSASFREAIRGGIHLDSIAAGEAAAAKKEESNASSPFSLRLAQYVLEHYDQDLSLKTLAVHFKGNAAYIGQIFKRDMHKSFSDYLKDVRMEKAKELLENSSLSAKDIAVKVGFQNVTYFSTVFKKETGLSPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJJ4</accession>
    <name>F7KJJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255804.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06028"/>
    <dbReference type="EnsemblBacteria" id="EGN31382">
        <property type="protein sequence ID" value="EGN31382"/>
        <property type="gene ID" value="HMPREF0994_06028"/>
    </dbReference>
    <dbReference type="GeneID" id="29725266"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033229_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356987" evidence="1">
        <location>
            <begin position="32"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="608" mass="67626" checksum="8C181AF02D1FC4ED" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJM1</accession>
    <name>F7KJM1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255831.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06055"/>
    <dbReference type="EnsemblBacteria" id="EGN31409">
        <property type="protein sequence ID" value="EGN31409"/>
        <property type="gene ID" value="HMPREF0994_06055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6629"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014132_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN31409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="490" mass="56739" checksum="AF6EBAA8D1ABB948" modified="2011-09-21" version="1">MRRSGILMPVSSLPSEYGIGSFSKEAYEFVDFLESAGQKLWQILPLGPTGYGDSPYQSFSTFAGNPYFIDLESLVEEGWITRAECDKMDFGEDECYIDYEKMYHSRFRILKKAFDKSGIEEKPEYQEFVKENAFWLEDYSLYMAIKDSLGGASFLTWEQDIKLRREEALEEWRKKLSKEIAFYKFQQFLFTKQWLALKSYANKKGILIVGDIPIYVALDGADTWANPELFQLDEDCTPLAVAGCPPDAFSATGQLWGNPLYRWEYHKETGYAWWMKRISYCYKLYDILRIDHFRGFESYYSIPYGDPTAEFGHWEKGPDYDFFRTLKQELGAKEVIAEDLGYLTPAVLKMVKKTGYPGMKVLQFAFDPREESDYLPHNYTQNSVVYTGTHDNQTTTAWVEEIGREDRAFAKQYLNVKRSKDVPEAMVRAALSSVSDTAVIPVQDWLGLGAEARINTPSTLGENWKWRLKKGQCSQELAEHIRTMTRLYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJR8</accession>
    <name>F7KJR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255873.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN30723">
        <property type="protein sequence ID" value="EGN30723"/>
        <property type="gene ID" value="HMPREF0994_06097"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032HYI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846727_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="328" mass="37220" checksum="4155E1A9A5BF4B51" modified="2011-09-21" version="1">MSKHGMKRLWAAVFLLTAAIIITGSGYNRIKTRTSDTENSKIPPSSKEAVLNLETRGKNKIQAGNRETMNRLAVTENGSIIFAMEKGPSENQEDFEEWYVTSPYKNKQLVNVSDLYAFLEHYAAWDYLNQAENVEFRDSGLAVEESFTDSGTVRFLIGQKNKNGNYYVKEERTGRLYEIDGTQTEAMTGLKPYDFIMGIANLVYLTTVDKLEIRTKETAAVFRVETDEDRNQVFIKEGQVMEEDGFKKMYSSIISIVAVKEAEDSTASGQPALQLSFSRNTDKLKNTQISYIPYNEEYYLIIKDGQSDFLAEKSAVDDVIAVIDEYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJV6</accession>
    <name>F7KJV6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255911.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06135"/>
    <dbReference type="EnsemblBacteria" id="EGN30761">
        <property type="protein sequence ID" value="EGN30761"/>
        <property type="gene ID" value="HMPREF0994_06135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6718"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="340" mass="37198" checksum="78DA7C91998C7FDF" modified="2011-09-21" version="1">MSKVVTFGEIMLRLAPEGYYRIVQAEKYVATYGGGEANVSVSLANYGLDSKFVSKLPKNEIGQAGVNSLRKFGVDTSDIVRGGNRVGIYYLEKGASQRPSKVIYDRAGSSIAEAVKEDFDWDKIFEGADWFHFTGITPALGDNVAEICMEAVKKAKEKGITVSCDLNYRNKLWSKEKAGQVMGELCKYVDVCIANEEDAGDVFGIKAANTDVTSGQVNHEGYKDVAKQLADRFGFSKVAITLRSSISANDNKWAAMLYDEGNYYFSKNYLMHIVDRVGGGDSFGAGLIYSCLQNMEPQQIIEFAVAASCLKHSIEGDFNMVTVDEVMKLAGGDASGRVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJY8</accession>
    <name>F7KJY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255953.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06177"/>
    <dbReference type="EnsemblBacteria" id="EGN30670">
        <property type="protein sequence ID" value="EGN30670"/>
        <property type="gene ID" value="HMPREF0994_06177"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081493_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="208" mass="23744" checksum="E1F8010CE31CBB6F" modified="2011-09-21" version="1">MEQKFVKTHFVEMNLSDILEQLGEDETKSILSSFVCPLNEDVEFFIKYRAIEFSKRTTAKTHLVFWQTEETKEIEFVGYYTIASKVITVNKDALTGGESKKLKNQGYYDEVKHEFTISAPLIGQLGKNFANGNNTLISGSDLLQLAINKVRTIQKEIGGRFVYLECEDNENLLSFYKNCGFKVFGSRKLDGDETGIRGKYLIQLFAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKA0</accession>
    <name>F7KKA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256049.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06279"/>
    <dbReference type="EnsemblBacteria" id="EGN30198">
        <property type="protein sequence ID" value="EGN30198"/>
        <property type="gene ID" value="HMPREF0994_06279"/>
    </dbReference>
    <dbReference type="GeneID" id="29726899"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110305_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="28582" checksum="9C742C594E33AF0F" modified="2011-09-21" version="1">MRKKCFIGFDGYRDEIYRLIKRRTKEGYEFWDKMEDLGSYLQNNCGRSSDIELMPAAAGIGGNGPLMAGAIASLGIQTTCMGLFDDCSDLMENLNHKVNCLSIGRSNRCTALEFSNGKLMLGQLESMKLDCDDFRNRFNQEEVIHIWRECSLIGIVNWSAFLYMNDILAFLEPFLMEQEMPQLLFFDLADLTARSREDILGLVSLLKRFGKRKQVILGLNNKEAEIFVQQFRSVYKELHADHETGAADNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKC2</accession>
    <name>F7KKC2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256071.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06301"/>
    <dbReference type="EnsemblBacteria" id="EGN30220">
        <property type="protein sequence ID" value="EGN30220"/>
        <property type="gene ID" value="HMPREF0994_06301"/>
    </dbReference>
    <dbReference type="GeneID" id="29726945"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6905"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="279" mass="31107" checksum="D50D0CB7A997417B" modified="2011-09-21" version="1">MAGKMIQKAVLTAMKYILLALFFLFTVFPFFWLLVSSLKGSKELYEFPVHYLPREASLNNYREVIEMGNFGLYILNSLFIALAGACLVVLIAGMSSYILSRMEFKSKPLIFMVFMMTQMLPTAVGFAPLYILMSRMGMINRLTTVIIILVGGQIPFGTILLIGFMKGIPKALEEAALIDGCGRIKTFFRIVMPLAKSGLFSVFIFVFLACWNDVYTSVLYINANSKKTLTVAIYSMIGKYDINWGNVAAGTLIAMLPAILLFGFMKEIFVENIAGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKH1</accession>
    <name>F7KKH1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ORF">HMPREF0994_06350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256112.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06350"/>
    <dbReference type="EnsemblBacteria" id="EGN47958">
        <property type="protein sequence ID" value="EGN47958"/>
        <property type="gene ID" value="HMPREF0994_06350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6954"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="251"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN47958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="322" mass="35565" checksum="E52D80D2574F4715" modified="2011-09-21" version="1">MFDFERPNIEVAEISEDKKYGKFVVEPLERGYGITLGNSLRRIMLSSLPGAAVSQVKIEGVLHEFSSIPGVKEDVTEIIMNIKSLAIKNSSETNEPKTAYIEFEGEGVVRASDIQADQDIEILNPDLVIATLSGGKESKLYMELTITKGRGYVSAEKNKSEDLPIGVIAIDSIYTPVERVNMSVANTRVGQVTDFDKLTLDVYTNGTLAPDEAVSLAAKVLSEHLSLFIDLSENAKTAEVMVEKEDDEKEKVLEMSIDELELSVRSYNCLKRAGINTVEELTNKTSEDMMKVRNLGRKSLEEVLAKLKELGLQLNPSDDVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKK6</accession>
    <name>F7KKK6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">HMPREF0994_06385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256147.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06385"/>
    <dbReference type="EnsemblBacteria" id="EGN47993">
        <property type="protein sequence ID" value="EGN47993"/>
        <property type="gene ID" value="HMPREF0994_06385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6989"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN47993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="12508" checksum="BC25A17605A0FAF8" modified="2011-09-21" version="1">MHELGILMEIVKTVEKFAVENQVDKIETLVLQIGEISSVIPEYMKKVYPAAVEETMLENAELEIEILPANGLCLDCGKEFHATVCGGICPDCGSRNMKLVSGRDFFIKEIVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKL0</accession>
    <name>F7KKL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256151.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06389"/>
    <dbReference type="EnsemblBacteria" id="EGN47997">
        <property type="protein sequence ID" value="EGN47997"/>
        <property type="gene ID" value="HMPREF0994_06389"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6995"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN47997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="33122" checksum="CFA7C41B6FBD3D57" modified="2011-09-21" version="1">MELKLDGITKEFHGFTAVDQVSCRMRNGVYGLLGVNGAGKTTLMRMLCTLLKPTEGKITCDGQDIFEMDGEYRKRLGYLPQEFGFYPDFTVQDYLMYIASIKGLRQAAAKKRVMELLPRVGLAKVVHKKMKKLSGGMKRRVGIAQAMLNDPEILILDEPTAGLDPNERIRFRNLLSGLSQDRLVLLSTHIVSDVEYIANEIMLMGDGHIVRSGTPEKIMSSVPDRVWSCTVPRSKAQDWAKEYKVANMKTTSGGVELRILCEERPCPDAKQEEITLEDVFLYYFGEKGGDEDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKR0</accession>
    <name>F7KKR0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nanE</name>
        <name evidence="7" type="ORF">HMPREF0994_06439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256201.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06439"/>
    <dbReference type="EnsemblBacteria" id="EGN47574">
        <property type="protein sequence ID" value="EGN47574"/>
        <property type="gene ID" value="HMPREF0994_06439"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7049"/>
    <dbReference type="eggNOG" id="COG3010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086300_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="235" mass="25990" checksum="F271023F43EC79A6" modified="2011-09-21" version="1">MSEKISQIYKKLIVSCQALPDEPLHSSFIMGRMAKAAKEGGACGIRANSREDIEEIKRNVELPIIGIVKKEYADSPVYITPTMREVDALVEAGADIIALDATGSRRPGGVLLDDFVEEIRNRYPGQPLMADCSTVEEVLHADRLGFDFLGTTLVGYTEQSAGKQIEENDFEIIRQILEKVNHPVIAEGNINTPQKARRVLEIGCYSVVVGSIITRPQVITRTFTEEIDKLAMAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKV8</accession>
    <name>F7KKV8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, family IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256249.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06487"/>
    <dbReference type="EnsemblBacteria" id="EGN47498">
        <property type="protein sequence ID" value="EGN47498"/>
        <property type="gene ID" value="HMPREF0994_06487"/>
    </dbReference>
    <dbReference type="GeneID" id="29729798"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7103"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN47498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="207" mass="23174" checksum="49E24793AE047DAC" modified="2011-09-21" version="1">MDKRHFIFDIDGTLINTEKAIIKGLQELLLEIKGVPYEPEQLYFCLGIPGPITLKQLGVEGDLTAILKKWDAYYCKHGGDVTIYPDIPEVLKKLKENGISLGVITSKNQEEYDYDMIRLGLADYFSITVTATDTSEHKPDPAPMLFYLEKAGILPEQAVYIGDSIYDMKCAEGAGVPRALALWGCKNPEEITADYRLSRPIDILDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKX8</accession>
    <name>F7KKX8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47518.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360345.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06507"/>
    <dbReference type="EnsemblBacteria" id="EGN47518">
        <property type="protein sequence ID" value="EGN47518"/>
        <property type="gene ID" value="HMPREF0994_06507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47518.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="32668" checksum="9AB57CD7C091DD39" modified="2013-09-18" version="2">MDKKKKKISERTRTLFLFTLPSVVMYTVFFTVTMAIGIYYSFTDWNGISASYKIIGIGNYIKALMDRKFQAALKFNFVYTFLFVLILIVISLLVAICLNNLTKTSTIFRSIYFLPAVLSMVTVGLIWNELFYRALPVIGKALNIGWLSNSLLGNKTTAMFGILIVNLWQGCSIPIVLFLAGLQSVPSELYEAATIDGANRWDKFKSITFPFLIPVLNMVIITQVKAGLTIFDYIMAMTNGGPGGATQAVGILIYNQAMKGNAYSQSVAESMILFVIVAIVAAVTLKMTKNKQVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL73</accession>
    <name>F7KL73_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862439.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06606"/>
    <dbReference type="EnsemblBacteria" id="EGN47325">
        <property type="protein sequence ID" value="EGN47325"/>
        <property type="gene ID" value="HMPREF0994_06606"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7229"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_4_8_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="45124" checksum="1B018F5BFA968E0D" modified="2011-09-21" version="1">MNCVGIDVSKGKSMIAVMRPFGEVVVSPFEVRHTASELSELARLLKNLDGETRVVMESTGNYHAPVAWLLHGAGFYVSVVNAMLVHDYGNNSLRRGKTDKKDAVKLANYGLDHWLTLPRYVPEEDTRLMLKTCYRQYQQYSKVQTMLKNNLISLLDTAFPDANRLFTSPPRADGSEKWVDFVATFWHCECVCGLSKKAFTAKYQKWCRKHGYNFSQDKALDIYASACGRFGVMPKTNTAKLLVEQAISQLQTTSAALAALKQEMQSLAASLPEYPVVMEMFGVGPTLGPQLIAEIGDVRRFHSKKALVAFAGIDAPPYQSGQIDVRSRSISKRGSASLRRTLFLVMGVLLQCAPMDEPVYQFMNKKRSEGKPYRVYMMASANKFLRIYYASVKAYLDSLEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL91</accession>
    <name>F7KL91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_06620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256374.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06620"/>
    <dbReference type="EnsemblBacteria" id="EGN46971">
        <property type="protein sequence ID" value="EGN46971"/>
        <property type="gene ID" value="HMPREF0994_06620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7242"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_2_0_9"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="12">
        <location>
            <begin position="331"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN46971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="420" mass="47145" checksum="35013D13DEAD9460" modified="2011-09-21" version="1">MSNYKIAVAGTGYVGLSIATLLAQHNKVVAVDIMPEKVEMINNRKSPIQDDYIEKYLAEDAAGTRKLDLTATLDAEAAYSDSDFVVIAAPTNYDSEKNHFDTSAVEAVIKLVIQYNPDAVMVIKSTIPVNFTTSVREKYHCENIIFSPEFLRESKALYDNLYPSRIIVGTDVENARLVKSANIFAGLLQEGAIKEDIDTLIMGFTEAEAVKLFANTYLALRVSYFNELDTYAEMKSLDTQQIINGVCLDPRIGSHYNNPSFGYGGYCLPKDTKQLLANYEDVPQNMMSAIVESNRTRKDFIADRVLEIAGFYGDYNRGDFAPGEEKKCVVGVYRLTMKINSDNFRQSSIQGVMKRIKAKGVAVIIYEPTLEDDSTFFGSKVVNNLEKFKELSQVIIANRYDSVLDDVKDKVYTRDIFQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLG4</accession>
    <name>F7KLG4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="11">IGPS</shortName>
            <ecNumber evidence="4 11">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpC</name>
        <name evidence="13" type="ORF">HMPREF0994_06698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4 11"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256451.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06698"/>
    <dbReference type="EnsemblBacteria" id="EGN46622">
        <property type="protein sequence ID" value="EGN46622"/>
        <property type="gene ID" value="HMPREF0994_06698"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7325"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_2_0_9"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="12">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN46622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="28743" checksum="49DCBF2049156551" modified="2011-09-21" version="1">MILDTIAEKTRERVKIRKQAVPLEQLRKEAEQLSPDTGFPFERALGKEELSFICEVKKASPSKGLIAPDFPYLQIAGEYEAAGASAISVLTEPDFFLGSDQYLKEIAGKVSIPVLRKDFTVDAYMIYEAKLLGAAAVLLICAILTEEELKSYLALADSLGLSALVEAHDRQEVEMALRCGARIIGVNNRDLKTFQVDITNSVRLRKLVPADILFVSESGMKTAQDIQILRENGTNAVLIGETLMRSPDKCRELDILRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLI2</accession>
    <name>F7KLI2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256473.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06720"/>
    <dbReference type="EnsemblBacteria" id="EGN46644">
        <property type="protein sequence ID" value="EGN46644"/>
        <property type="gene ID" value="HMPREF0994_06720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7349"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890555_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357542" description="SGNH_hydro domain-containing protein" evidence="2">
        <location>
            <begin position="40"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="92"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="322" mass="34774" checksum="26F639309F0F06C4" modified="2011-09-21" version="1">MKKRKSSGNFIGIGLLCLLFLCVAVFSIFFVCCSKPSSDSSEETIPPETFSETGGISDNTAAQTESSVPPFEEASTEQKEARNLTGLKLSILGDSISTFDGYIPTDYNIFYPNYGDISTVEKTWWFQVLSSTGMELNANASSSNTDVSGDSSDTTGSAPGCSFKRINDLTPGDDGPAPDILIVFMGVNDFLRSVELGNFTTPEAQQEGVITNFCDAYELMLQKLAATYPKTQIYFCTLLETNAGDVDDNPGAFPSTNENGNTIADFNAEIATIASAYNYPVIDVHNCGITYDNLSDYTIDGTHPNAEGAHLIAEYITKSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLN1</accession>
    <name>F7KLN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256513.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06760"/>
    <dbReference type="EnsemblBacteria" id="EGN46352">
        <property type="protein sequence ID" value="EGN46352"/>
        <property type="gene ID" value="HMPREF0994_06760"/>
    </dbReference>
    <dbReference type="GeneID" id="29726863"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7386"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062212_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="39303" checksum="FD9C6878EEC95E58" modified="2011-09-21" version="1">MKKNILAVCDTEQEFTCHLTDYLGQLAGSDSFPFEVQVFTDSRALEEFCGKNRAAFLLLTQEVYREALDWEDDSWKMARLLILEEEGEAPPGLERVNKYQSMDNIVRKIMEIAADAGILPPAAVGERSGNVHFIGIYTPVSRCLQTTFSFTLGQLLARRHKVLYLNFESYSGLARMLQREFSTDLSDLIYFLHNGDDRFPYRLEGMVQKVNGLAFIPPVFSCMDLQRIEAEEWLRLFEELDISGSYEYVLLDLSEAVQGLFDILRLCTRVYTITRDDGFAAAKQEQYEELLRCLDCEDILRKTRKFRLPLFRQLPAGLENLTHSELAALVQEIIREDWKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLR8</accession>
    <name>F7KLR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06797"/>
    <dbReference type="EnsemblBacteria" id="EGN46389">
        <property type="protein sequence ID" value="EGN46389"/>
        <property type="gene ID" value="HMPREF0994_06797"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7427"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="414"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="511"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="606" mass="68762" checksum="E2E3B1BFB875157B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLT7</accession>
    <name>F7KLT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretion system protein VirD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN46326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06816"/>
    <dbReference type="EnsemblBacteria" id="EGN46326">
        <property type="protein sequence ID" value="EGN46326"/>
        <property type="gene ID" value="HMPREF0994_06816"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7448"/>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015347_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TraG-D_C" evidence="1">
        <location>
            <begin position="69"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="28433" checksum="34B7EF349C7BD0C5" modified="2011-09-21" version="1">MFDIAELREVTAYDELELDTLGDRKTALFLIMSDTDDSFNFLISMCYTQLFNLLCEKADDVYGGRLPVHVRCLIDECANIGQIPKLEKLVATIRSREISACLVLQAQSQLKAIYKDNADTIIGNMDTSIFLGGKEPTTLKELAAVLGKETIDTYNTGESRGRETSHSLNYQKLGKELMSQDELAVMDGGKCILQLRGVRPFLSDKYDITKHPNFQYTADADDKNAFDIEAFLSARLKLKPNEVCDVYEVDTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRF6</accession>
    <name>S2KRF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000023">
        <property type="protein sequence ID" value="EPC05029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07323"/>
    <dbReference type="EnsemblBacteria" id="EPC05029">
        <property type="protein sequence ID" value="EPC05029"/>
        <property type="gene ID" value="HMPREF0994_07323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056705_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029465">
        <property type="entry name" value="ATPgrasp_TupA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14305">
        <property type="entry name" value="ATPgrasp_TupA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="236" mass="27648" checksum="E0EC3B5F8F58BE57" modified="2013-09-18" version="1">MVDKYEAKKYVAERIGEEYIIPTLGVWDNFEEIDFDSLPNQFVLKTTHDSGGVVICRDKISFDKKKAREKLEKSLKRNYYMQGREWPYKDVKPRIIAEQYMVDESGYELKDYKLFCFDGFAKAMFIASDRYKAGEETKFDFFDMDFKHLPFTNGHPNAEHEIKRPESFEKMKELAGKLSEGIPQVRVDFYDINGQIYFGELTLSHWGGMVPFKPEEWDYKFGEWIKLPDSIGGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVN9</accession>
    <name>S2KVN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EPC05055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360312.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07304"/>
    <dbReference type="EnsemblBacteria" id="EPC05055">
        <property type="protein sequence ID" value="EPC05055"/>
        <property type="gene ID" value="HMPREF0994_07304"/>
    </dbReference>
    <dbReference type="GeneID" id="29729287"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031786_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010964">
        <property type="entry name" value="M20A_pepV-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01887">
        <property type="entry name" value="dipeptidaselike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="486" mass="54307" checksum="C16CBF23216A7766" modified="2013-09-18" version="1">MDKGYDSHTYEKVGQWFEEHREEMAEDIKRLVRIPSISDPQAETGPFGKACRDAMDEMLAMGRKYGFFSENKEYYVGTIGREKKDWNNTIGLWNHLDVVPLGEGWDYAPFDPVVRDGYLIGRGAQDNKGPAVAMLYVMRCIRDLKLDMKHEICLFVGCDEERGMADLEYYGSRYPFPALSMIADCGFPVCYGEKGILEGWAAADDSFSEDVIDLYGGSAGNIIPDRAVLVLRDRPELEEPLRQLPEALQAEKEEGQIRITARGTSRHSAFPEGSVNAIHELAKAVCASSLLKEEDRKLLHFIEEATSDYYGERIGIAYEDEVSGRLTCAGTVLKLQEGKAALQFNIRYSITADPEHMEAVLDGFCRTSGYHWELIRNSAPNYFPKERKEVALLTSLFNELTGSDSKPYVMGGGTYARKLPNAFGYGIGSMPEREDDRASELFAKGHGGAHEPDEGLDLKKLLDAAKIYTMAMLTLNDCEISGNPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWC4</accession>
    <name>S2KWC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_07119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359996.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07119"/>
    <dbReference type="EnsemblBacteria" id="EPC05270">
        <property type="protein sequence ID" value="EPC05270"/>
        <property type="gene ID" value="HMPREF0994_07119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="328" mass="36638" checksum="7D68B303AC10ABEE" modified="2013-09-18" version="1">MSEQETLLSIRNLKTYFVTDEAVLKAVDDVSFEVKKGETLGVVGESGCGKSVSCMSIVKLVQGGNVKYEGGQILFEGRDTLQMTEKELRKIRGKDISIIFQEPMTALNPLYTIGDQMKEALKNHQKISDRQARERCVEYLKKVKIPMPEEMMFRYPFSLSGGMRQRVMIAMALITSPKLIIADEPTTALDVTIQAQILDLMNALKEETGSSCIFITHDLGVISEMADRVVVMYGGKVCEVSPTDELFEHAAHPYTLGLIHSRPRADFEGDRLEVIPGNVPSLNDKPEGCPFHPRCRYAGKKCEKEFPEAALLSGEHKVFCWKYCGGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAT7</accession>
    <name>S2LAT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06979"/>
    <dbReference type="EnsemblBacteria" id="EPC05311">
        <property type="protein sequence ID" value="EPC05311"/>
        <property type="gene ID" value="HMPREF0994_06979"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2585209_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="80" mass="9363" checksum="7DE787E71E73CED2" modified="2013-09-18" version="1">MKKENKHRKRIPQPFAGGNPFSHSFFLKIGEEEVEVKLCYPVISRQIQGRRYRKNELNSSEEGGQLYDERYFLCVAEAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAV5</accession>
    <name>S2LAV5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359783.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06999"/>
    <dbReference type="EnsemblBacteria" id="EPC05331">
        <property type="protein sequence ID" value="EPC05331"/>
        <property type="gene ID" value="HMPREF0994_06999"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033NUX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828213_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="30629" checksum="99E43C31873269A1" modified="2013-09-18" version="1">MNCRFCGAEVEEGAKFCQKCGKNLEEVSDKKNCPKCGSELEKDAKFCLKCGYSMEKKAAGNGKKKLIIGIVALIAVICIGGGIGVVVHQKAVEKERYEQELAAERERQEAERARQELINAYGAKAMELNNAINGTENNFNLLSSMYDTSTGINTGLLGPDFFTDYVEGLCSSEINTEKDRKREIDKIYTELQDIGCDEEEVKELKKAMEDYYYAYCERYSFLVEGDFSVNNFKAKEETSKKDFTDKAAVVKSLIRNVNTLGTTEESEIEEGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJW0</accession>
    <name>S2LJW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-4-keto-6-deoxy-N-acetylglucosamine 4-aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EPC05228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360001.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07121"/>
    <dbReference type="EnsemblBacteria" id="EPC05228">
        <property type="protein sequence ID" value="EPC05228"/>
        <property type="gene ID" value="HMPREF0994_07121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020026">
        <property type="entry name" value="PseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03588">
        <property type="entry name" value="PseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="44825" checksum="82D9CA2B20A0A6DB" modified="2013-09-18" version="1">MKENIQEIPAIAGGTPVRDTKISYGHQYLDEADYQAVLDVLKNGPLTCGPKIGELEDKLCRITGARHAVSVSNGTAALHIACLAAGVGEGDEVITTPITFAASANCALYCGAKPVFADINEKTYEIDPASVESCITEKTKAVVAVDYTGQSADLKALRKICDEHKLVLITDGAHSIGTFYDGKPTGSIADMTTFSFHPVKTVTAGEGGAVMTDSDELYKRLVLFSKHGITRNPDWLENVPDGPWYYEQIELGYNYRMTDIQAALLISQLDKLEMFKARRKEIVKRYNEAFSRIPQIMVQEEIPDSDTTRHLYILRIRPERLSIGRKEFFEALGAENICCNVHYIPTYYFPYYQRLGYKKGLCPKAEKLYEEIMSLPLYYAMSDKDVEDVITAVKKIAAYYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2G8</accession>
    <name>F7K2G8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249996.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00047"/>
    <dbReference type="EnsemblBacteria" id="EGN48280">
        <property type="protein sequence ID" value="EGN48280"/>
        <property type="gene ID" value="HMPREF0994_00047"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.50"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="264"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="298"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN48280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="488" mass="54437" checksum="A7129E6E8FD52788" modified="2011-09-21" version="1">MIDFQNVSFSYGEESSGGGIRNVNLTINTGEFVLLTGESGCGKTTITRLVNGLVPHYYEGNLEGDVLLDGKSVSDTPLYDLAAMVGSVFQNPKSQFFNVDTDSELAFACENLGYPQEDILKRIDRTVSDYHIEDLMGRSVFALSGGEKQKIACASSSVLLPGIMVLDEPSSNLDMAAIDDLRQVLSLWKKQGKTILIAEHRLYYLHDLADRVLYVKDGEIEREYTPAEFDSLSDSTRKEMGLRPFSLSKLKPANQYQAHTAKLMEFQNFCFAYKKREPESLHIPSAELPVGETIAIIGLNGAGKSTLARCICGLEKKCGLLQVDGKTLDWKARLKHCYMVMQDTSHQLFTESVMDEVLLSMDNEDETVADEILKQFDLLEYKDRHPLSLSGGQKQRVAIASAIVSNREIIVFDEPTSGLDLKHMWEVARSLKSLADQGKTLLVITHDPELVMAGCSYVVHMEKGQIKESYPLDESGSKKVLDFFRIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2M8</accession>
    <name>F7K2M8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250056.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00107"/>
    <dbReference type="EnsemblBacteria" id="EGN42724">
        <property type="protein sequence ID" value="EGN42724"/>
        <property type="gene ID" value="HMPREF0994_00107"/>
    </dbReference>
    <dbReference type="GeneID" id="29725784"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.114"/>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029245_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="4">
        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="4">
        <location>
            <begin position="462"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN42724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="615" mass="66240" checksum="DB1EF6092AAE71B3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K386</accession>
    <name>F7K386_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250264.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00315"/>
    <dbReference type="EnsemblBacteria" id="EGN33456">
        <property type="protein sequence ID" value="EGN33456"/>
        <property type="gene ID" value="HMPREF0994_00315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.340"/>
    <dbReference type="eggNOG" id="ENOG5032Z8R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176907_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="80" mass="8905" checksum="1C24BB5B6296B330" modified="2011-09-21" version="1">MIIDTKSIVSITEANQNFSKVARLVDELGSAVIMKNNVPKYLVIEFVKADNQENASDESVMALSRKLMEANKEAYEVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K388</accession>
    <name>F7K388_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250266.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00317"/>
    <dbReference type="EnsemblBacteria" id="EGN33458">
        <property type="protein sequence ID" value="EGN33458"/>
        <property type="gene ID" value="HMPREF0994_00317"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.341"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="18880" checksum="4358089166683CD5" modified="2011-09-21" version="1">MNTSEAIRARRSIRKYKKGTVIPKEHIHQMLEAAMMAPSACNTRPWEFVVVETEEIREQIMKSHPYTQMLKTASLAIVVCGRPDLQESVCAGFWPQDCGAAIQNLLLQAKELGYGTCWCGCYPVMERVKELQEILSVTSQPLAVIAVGEADEEPAARGFYDETRVKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3D1</accession>
    <name>F7K3D1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250313.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00364"/>
    <dbReference type="EnsemblBacteria" id="EGN33505">
        <property type="protein sequence ID" value="EGN33505"/>
        <property type="gene ID" value="HMPREF0994_00364"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.394"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="115" mass="13121" checksum="FEF410950C77492E" modified="2011-09-21" version="1">MENMKKIPDCPVEMTLQLIGDKWKVLIIRDLLSGTKRFSELMRSVTGITQKVLTSNLRSMEAAGLLTRKVYPEVPPRVEYTLTETGYSLKPIMDSMVDWGTWYKNHIASASPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3U1</accession>
    <name>F7K3U1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FlhB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">flhB</name>
        <name evidence="14" type="ORF">HMPREF0994_00520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the type III secretion exporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250469.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00520"/>
    <dbReference type="MEROPS" id="N06.A01"/>
    <dbReference type="EnsemblBacteria" id="EGN45524">
        <property type="protein sequence ID" value="EGN45524"/>
        <property type="gene ID" value="HMPREF0994_00520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.569"/>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006136">
        <property type="entry name" value="FlhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00328">
        <property type="entry name" value="flhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN45524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="352" mass="39805" checksum="B5E6A275A0EBA0C3" modified="2011-09-21" version="1">MAADEKTEKATPKRKQDERKKGNVFQSSDVAAVASLLAVFNGLKIFASFMYKSMYQGVILFFGYARMEYPVNSESLQDKLIQAMLLFAQAALPLLLIAGVTAVAVAALQTRMAFSMETIKFKAYRISPLQGFKRLFSIRSVVELLKALIKITVLGWMIYSFLSSRMHEFVRLMDGTVMDAISFAGNTVLSLVNTVGVAFLFLAAFDYLYQWWDYEKNLRMSKQEIKEEYKQTEGDPQIKGKIREKQRQMSSKRMMQNVPKADVIIRNPTHFAVALGYDPERNKAPVVLAKGADRVALKIVEIGEANDVYIMENRPLARGLYDAAEIDMEIPGEFYQAVAGVLAFVYKLKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3V5</accession>
    <name>F7K3V5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliW</name>
        <name evidence="4" type="ORF">HMPREF0994_00534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00534"/>
    <dbReference type="EnsemblBacteria" id="EGN45538">
        <property type="protein sequence ID" value="EGN45538"/>
        <property type="gene ID" value="HMPREF0994_00534"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112356_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="156" mass="17686" checksum="E42CC5B987544892" modified="2011-09-21" version="1">MAYRRNRQLKIETRDFGIIDVEEENIITFKQPVFGFEDYTQFVLVTDSNMGNGICWLQSIEQKGICFIMLNPLEICPDYAPAVMQDVLFTLQAVPKDDLDCWVIAVIGDTFCESTVNLKSPIIINHKTNLGMQVILDQDYPIRQPIFDSKGGGVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3X6</accession>
    <name>F7K3X6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar motor switch protein FliN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250504.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00555"/>
    <dbReference type="EnsemblBacteria" id="EGN44743">
        <property type="protein sequence ID" value="EGN44743"/>
        <property type="gene ID" value="HMPREF0994_00555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.603"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033893_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="8">
        <location>
            <begin position="263"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="37870" checksum="76E490B782D49771" modified="2011-09-21" version="1">MAAEQEIRNMSEDNIFDALMEQYGKAAGESISAMLKTKVEIKAPEKSETLVKDVEYSILEPALFVKSCLTSNAAGNIVMIFRQRDIQAFLNKLMGSDDLPDPDFEFDEVAMSAAGELLNQMVHSAAKSVAEYLENTMDSSDCQLFLSDSGQRLWEIMGEDAACKTTVIRYGMTIGDLMETEFLECISETATDSLMQEITVKKQKEEERAVREEEERNSIQIMDSMPDENGTGLLAAGRIDGTAYRETAQLQPVSIPQGNLGLLMDVPLHVSVEIGKTRRKLKEILSLNNGMVVELDKQADAPVDIIVNGQLIARGEVVVIDDNFGVRISEIVNTKSIIENGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3X8</accession>
    <name>F7K3X8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250506.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00557"/>
    <dbReference type="EnsemblBacteria" id="EGN44745">
        <property type="protein sequence ID" value="EGN44745"/>
        <property type="gene ID" value="HMPREF0994_00557"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173020_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="69" mass="7917" checksum="8237607696C4416A" modified="2011-09-21" version="1">MIFLRKLNGERFVLNPDLIEMVSENPDTTILLTNGKHLIVRETMDEVVEKIREERRNIVRELLGGAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K429</accession>
    <name>F7K429_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_00620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00620"/>
    <dbReference type="EnsemblBacteria" id="EGN44808">
        <property type="protein sequence ID" value="EGN44808"/>
        <property type="gene ID" value="HMPREF0994_00620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.673"/>
    <dbReference type="eggNOG" id="COG1536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047835_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003161">
        <property type="entry name" value="FliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="120"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="222"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN44808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="338" mass="38290" checksum="3A33E7E0F2FF0CD6" modified="2011-09-21" version="1">MAAESSKKLTSEQKAAAVIVALGADKASKVYKYLGEEEVEKLTVEVAKLGHLDAEQSDDALDDFYKTCLTQKVVTDGGLEYARSVLEKAYGEATANELLSKVTKYLKNRSFEFIRKTDSKNLYSMLQHERPQTIALILSYTDSEQAAQVIAELPEDKKIPVVECIARMESASPEAIKLVESQLRHKFDNILTTDFTVIGGVDYIADVMNHMDRSNEKAIFDEMGKDDPELADTIRKKMFVFEDILTMDERSIQRFIRDCDMKDIVYALKNATEEMSDLFYRNMSSRMAETIQSDLEITVNVRLRDIEEAQQHIVNTIRRLEEAGELIINKGGKDDIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4I6</accession>
    <name>F7K4I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250714.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00765"/>
    <dbReference type="EnsemblBacteria" id="EGN43474">
        <property type="protein sequence ID" value="EGN43474"/>
        <property type="gene ID" value="HMPREF0994_00765"/>
    </dbReference>
    <dbReference type="GeneID" id="29724893"/>
    <dbReference type="eggNOG" id="ENOG5030J2G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193595_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363501" evidence="2">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="232" mass="26195" checksum="AE13EC443B1A0F4B" modified="2011-09-21" version="1">MKQIKLIVLVFVLMVSLTGCNNEKAGNEKNGETSVNEASEERDPAEVITFPTYEEANPERLPFIDKVNNTPAFHVKVNLPENWVVENRKPDVENLVPGDFYSMLFIYEKDTLIGYIGFNIFDPYEDPIPEEQYYQTVYPGLRLSSVFHWDPYEAVKTTDTAETGIADIWYLEPGEIDKHPGAMADVPQQETIGILSYDKELKVFIGMAFMPGTVSREQAEAVAQSISLSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4L9</accession>
    <name>F7K4L9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250750.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00801"/>
    <dbReference type="EnsemblBacteria" id="EGN43510">
        <property type="protein sequence ID" value="EGN43510"/>
        <property type="gene ID" value="HMPREF0994_00801"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="5">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN43510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="17789" checksum="C11BF409D9D654C4" modified="2011-09-21" version="1">MKIFGKLLKAAAKLFSIVLMAAILLQLAGSVFGGRELPALFGYSCLAVLSGSMEPAVSAGDLIVIHRQTDYKEGDIITFSEDSFYTTHRIIASDAGGYRTKGDANNIQDAAPVRSEQVAGKVKWIIPKAGKLFLAVRSPLAAACIFLLGAAAWLLSDQKKTGEKGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4N2</accession>
    <name>F7K4N2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250768.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00819"/>
    <dbReference type="EnsemblBacteria" id="EGN43528">
        <property type="protein sequence ID" value="EGN43528"/>
        <property type="gene ID" value="HMPREF0994_00819"/>
    </dbReference>
    <dbReference type="GeneID" id="29725770"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.894"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026278_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="427" mass="48540" checksum="ACAA0545AC551B8B" modified="2011-09-21" version="1">MVIYWFIGAFFLAEAIKEGIFVYSKRRLPGLQLLFGLGELLLFLLFSIIGVWGWRNSCIFPAAFLLWNLAGAWYALVRKRRKKAGIGRAVLRLLVLAFCLLPVVLFPPMKPVPASGSYACETASYVWTDETREESFRNDGAFRQVAVQFWYPAAENEEKFPLVVFSHGAFGYRMSNYSTYMELASNGYVVCSVEHPYHAIFSELEDGQIIMADKNFINDVFRVNEEGMPEEEVFALNRPWINLRTEDMNFVLDRIEEECGRETADLPFRLADIQRTGLMGHSLGGAAAVTVGRERPGVKAVIDLDGTMLGEELDYTDGKYLMNTEPYPVPLLCIDTTGHYVEGLKYGDQYVNHVILAEAEEAKEIHFDDAEHMNFTDLPLFSPPLAGLLGTGKRDARECIMTMNRLVLEYFDYYLKEEGELSLKEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5F5</accession>
    <name>F7K5F5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SporV_AA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251033.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01084"/>
    <dbReference type="EnsemblBacteria" id="EGN43057">
        <property type="protein sequence ID" value="EGN43057"/>
        <property type="gene ID" value="HMPREF0994_01084"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1190"/>
    <dbReference type="eggNOG" id="ENOG502ZCB6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098268_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021997">
        <property type="entry name" value="SporV_AA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038548">
        <property type="entry name" value="SporV_AA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12164">
        <property type="entry name" value="SporV_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SporV_AA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="210" mass="23712" checksum="D9F89D4B4397D9EF" modified="2011-09-21" version="1">MASQETLYLKLDRNVEVQKDDVQLSDLGKLVCANKDILAHAKAMKIYKFKDTKPQRQIVSVMKIIDSLQTMYPDLSIENIGETEVIMEKVKVKSEKGFMQWLKIAFVSLICFFGTAFTIMAFHNDIGINKVFVKVYEMISGQASDGFTILEVTYSIGLAVGIIVFFNHIGGRRITKDPTPIEVEMRIYEDDVNNALVETADREGKTIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5H7</accession>
    <name>F7K5H7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251055.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01106"/>
    <dbReference type="EnsemblBacteria" id="EGN42868">
        <property type="protein sequence ID" value="EGN42868"/>
        <property type="gene ID" value="HMPREF0994_01106"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1214"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="7">
        <location>
            <begin position="319"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN42868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="552" mass="61857" checksum="71E1EA38982F4F71" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5J3</accession>
    <name>F7K5J3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251071.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01122"/>
    <dbReference type="EnsemblBacteria" id="EGN42884">
        <property type="protein sequence ID" value="EGN42884"/>
        <property type="gene ID" value="HMPREF0994_01122"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1231"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="318"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="474" mass="51567" checksum="7BACEADDD1EFFE16" modified="2011-09-21" version="1">MVSITEGKHERFFIDFAWEKDGHIRSYRLGLEEVFEGKYLDTLFVPLQGQAFLLVGCGKEKELGLLEVREILAAAASKCREMKIRECSVDISRFAEALGKDAVLQGVLGLELGSYTYSFTGKEEDTACSFQLERISDMEDMEGLIAEAEELVKGIRFARDTVNTPGNHLRPMDFDRCITGFVKDVEIEAQTFVYGQLRAMGMEALYGIGGSSEYPPCLLILRYRGNPESDEIYGLIGKGVTCDTGGYCLKGSKSMAGIKGDMAGAAAVAGAMHAIAAGKLKVNVTACLPLCENRISQSAFLPGDVITGYGGKTIEILNTDAEGRLVLSDAVSYGIKDEKITKILDIATLTGAVWSALGYTIAGSMSDDDHFYGLFEKGLVHSTEKYLRFPFGREHRKMIKSDVADVKNVGADCCGSITAGLFIREFCEGKPWIHLDIAGTAWCDTPSFAFESKGATGAGVTSLYYMMKEAQNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5N5</accession>
    <name>F7K5N5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251120.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01171"/>
    <dbReference type="EnsemblBacteria" id="EGN42933">
        <property type="protein sequence ID" value="EGN42933"/>
        <property type="gene ID" value="HMPREF0994_01171"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1282"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="615"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="705" mass="78171" checksum="301F365CEB048CCD" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5N6</accession>
    <name>F7K5N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251121.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01172"/>
    <dbReference type="EnsemblBacteria" id="EGN42934">
        <property type="protein sequence ID" value="EGN42934"/>
        <property type="gene ID" value="HMPREF0994_01172"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1284"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="28931" checksum="A715DAAED35B653C" modified="2011-09-21" version="1">MELNMTGFPEEQLLPEGYQFNLSDFALFLSVMKNKDAYENTLSIILDEPDLKLAEVEVEQVVLNESGKRAIRLDAWARDVKNRHFNTEMQNDSKNDNLRKRSRFYQGLLDTPILKAGKKTKYRYLPSTVIIFITQEDIFSCDLAMYTFTEQCEEVAGLHLDDGTKKIFLNMASKNGRPELISLLQYMKNTTLDNPDILVRDKRIRKLDRIVKEVKQSEEWEAAKMNILEIGMEKGIQKGLEKGKLKGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5Z0</accession>
    <name>F7K5Z0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251218.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01269"/>
    <dbReference type="EnsemblBacteria" id="EGN42350">
        <property type="protein sequence ID" value="EGN42350"/>
        <property type="gene ID" value="HMPREF0994_01269"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1386"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477177_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363739" evidence="2">
        <location>
            <begin position="29"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="571" mass="64622" checksum="F085F571788D6BD2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K645</accession>
    <name>F7K645_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251273.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01324"/>
    <dbReference type="EnsemblBacteria" id="EGN42186">
        <property type="protein sequence ID" value="EGN42186"/>
        <property type="gene ID" value="HMPREF0994_01324"/>
    </dbReference>
    <dbReference type="GeneID" id="29726904"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026500_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="639" mass="74089" checksum="93FDE89475C96FB7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K687</accession>
    <name>F7K687_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VTC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251324.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01375"/>
    <dbReference type="EnsemblBacteria" id="EGN42237">
        <property type="protein sequence ID" value="EGN42237"/>
        <property type="gene ID" value="HMPREF0994_01375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1495"/>
    <dbReference type="eggNOG" id="COG5036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098613_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="230" mass="27413" checksum="EB7632E2F1A85DEC" modified="2011-09-21" version="1">MRNQAKYRYEIKYVCSDLQMLQMEEKISILLDRDSHVDEKGYYTIRSLYFDDYYNSAFYEKEDGNNPREKYRIRYYNNDKGRIHLEIKRKVGAKIQKESCAITEGEAAAMIEGQWAEIAGNTSKVVRNFFLNGMTRIFRPKIIVEYDRVPYVGKEGNVRITFDKNIRSSSQVEEFWEKDLSTRPIMPSGQHLLEVKFDEFLPDYIYNTLQMENMTQTAFSKYYLCRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6K2</accession>
    <name>F7K6K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251461.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01512"/>
    <dbReference type="EnsemblBacteria" id="EGN41986">
        <property type="protein sequence ID" value="EGN41986"/>
        <property type="gene ID" value="HMPREF0994_01512"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1650"/>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011540_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="328"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="412" mass="47304" checksum="E7CF0ACECBEC031F" modified="2011-09-21" version="1">MKDSNRKPELLIPASNLEVLKTAVIFGADAVYIGGEAFGLRAKAKNFSKEDMAEGIRFAHSHGKKVYVTANILAHNRDLDGARAYFRELKEIGPDALIISDPGMFTLARQEWPEVEIHISTQANNTNYMTYRFWWEQGAKRVVSARELSLAEIREIRENIPEEMEIESFVHGAMCISYSGRCLLSNYFTGRDANQGECTHPCRWKYAVMEESRPGEYLPVYENERGTFIFNSKDLCMIDYIPELVEAGIDSFKIEGRMKTALYVAAVARTYRKAIDDYFLSEEGYRQNRQWYQAEISKCTYRQFTTGFYFGKPSDEAQIYDNNTYVNEYIYLGIVGEVREDGLARIEQRNKFCAGDSIEIMKPDGRNITAEVLRIVDEEGSEVESAPHPKQVLYLELTEQPEKYDILRVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6P8</accession>
    <name>F7K6P8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251507.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01558"/>
    <dbReference type="EnsemblBacteria" id="EGN42032">
        <property type="protein sequence ID" value="EGN42032"/>
        <property type="gene ID" value="HMPREF0994_01558"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1702"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="379"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="591" mass="68425" checksum="57E470D42447D0DD" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Q5</accession>
    <name>F7K6Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HAD ATPase, P-type, family IC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01565"/>
    <dbReference type="EnsemblBacteria" id="EGN42039">
        <property type="protein sequence ID" value="EGN42039"/>
        <property type="gene ID" value="HMPREF0994_01565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1710"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="718"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN42039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="816" mass="89154" checksum="560E460571328BA4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Y9</accession>
    <name>F7K6Y9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251383.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01434"/>
    <dbReference type="EnsemblBacteria" id="EGN41908">
        <property type="protein sequence ID" value="EGN41908"/>
        <property type="gene ID" value="HMPREF0994_01434"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1562"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="128" mass="14378" checksum="12AB2EFF2F0C9BB8" modified="2011-09-21" version="1">MKVHHVGYLVKKLDKAAEEFEKLGFVRQGDMTNDTYRKVDILFLEKDGYVVELVSPNAPDSVVSGLIKTYKNAPYHICYESADFQADLEQLTQNGYVQIDQPAPAPAIGNRNVVFLMNSRLGMIELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7I0</accession>
    <name>F7K7I0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251722.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01809"/>
    <dbReference type="EnsemblBacteria" id="EGN41622">
        <property type="protein sequence ID" value="EGN41622"/>
        <property type="gene ID" value="HMPREF0994_01809"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1977"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="452" mass="48267" checksum="A3664AFDA216D3B3" modified="2011-09-21" version="1">MQTKDMTNGSPAGLILRFALPLMLGNVFQQFYTFVDTMVVGQALGVKALAALGAAEWLTFLMFGLVQGLVQGFSLVMARQFGAGDDKGLKKAVAGAVWLSLGAAVLFTALGQLMLRPVLLLLRTPTEIIDLTLIYLRILYASLPVAFAYNLLAALLRALGNSKTPLQAMTLSSFCNIALDLLFVFGFGWGIQGAAAATVLAQILAACFCCVKLRGSGLFSLGNKEYYPDRDVIREQLKLGLPMGLQNMITAMGGLIVQSVINGFGVLFIAGYTAANKLYGLLEIAASSYGYAMSTYSGQNMGAARYDRIGKGLRAANLIGAATALLMSAIMVFLGKPVLGCFLTGDSVTVEGAMRIGYYFLLVLAVFFPFLYILYVTRSCIQGMGNSLLPMISSIVQLVMRTGCALLLPALIGESGVFYGEVCAWLGADLLLAFSYFYCMKKLQTAAGPAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7N3</accession>
    <name>F7K7N3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_01927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01927"/>
    <dbReference type="EnsemblBacteria" id="EGN41332">
        <property type="protein sequence ID" value="EGN41332"/>
        <property type="gene ID" value="HMPREF0994_01927"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2116"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="265"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN41332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="410" mass="45857" checksum="C43B04266233FBD4" modified="2011-09-21" version="1">MNVTLIIILLCIIMSAYFSATETAFSSLNRIRIKNMADKGNKRAALVLKLSEDYDRLLSTILIGNNIVNIACASLSTLLFVRLLGEDAGASVSTAVTTVIVLVFGEVSPKSIAKESPEKFSMFSAPILNFMAVLLTPLNFLFKQWKKVLSRFFHSSASQGITEEELITIVEEARQDGGIDEQEGDLLRNALEFNELKAADILTPRIDVVGVNVCAGAEEIASVFTETGYSRLPVYQDSIDNIVGILYHKDFYNKIYGTGKGIKDVIRPALFITRHKKISQLLQELQASNHHIAVVIDEFGGTVGIVTLEDILEELVGEIWDEHDEIIRSVEKLSDDEFLVLGNANVDKLLELLGYDEETEAVTVNGWIMNELQKLPEKGDSFRFHEWQITVMEMEERRVKSARICRCEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7X6</accession>
    <name>F7K7X6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase CwlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251935.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02022"/>
    <dbReference type="EnsemblBacteria" id="EGN41427">
        <property type="protein sequence ID" value="EGN41427"/>
        <property type="gene ID" value="HMPREF0994_02022"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2219"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="116"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="236" mass="26669" checksum="2B305D030CB9D122" modified="2011-09-21" version="1">MRQELKEQLLKGVVTIILCTSVFFAARQAAVLVNEGTAQKTEQFCVVIDAGHGGDDPGKIGINGALEKEVNMQIAEKLKMFLEASDVKVVMTRESDGGLYDENASNKKVQDMKRRIQIIEEAQPNLAVSIHQNSYGEEYVNGAQVFYYNGSVKSKELAEMIQNRMIQYLDPENHRQAKANDSYYLLKKTGKPIVIVECGFLSNSAEAEKLCDNYYQEKVAWNIHMSIMQYLNTREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K821</accession>
    <name>F7K821_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251981.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02068"/>
    <dbReference type="EnsemblBacteria" id="EGN41473">
        <property type="protein sequence ID" value="EGN41473"/>
        <property type="gene ID" value="HMPREF0994_02068"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2269"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014875_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="294"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="668" mass="76216" checksum="BB42C6EFBC754686" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K835</accession>
    <name>F7K835_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251995.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41487">
        <property type="protein sequence ID" value="EGN41487"/>
        <property type="gene ID" value="HMPREF0994_02082"/>
    </dbReference>
    <dbReference type="GeneID" id="29728080"/>
    <dbReference type="eggNOG" id="ENOG502ZXSE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989663_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363792" evidence="1">
        <location>
            <begin position="32"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="31088" checksum="504CBFEFB266A467" modified="2011-09-21" version="1">MKLWKKAVSVLLGFCMMIGGLALALRMDVRAATLPVQVYVSPGQTVTINKDWTNIYMKDSSGACVPFTAYYYDSNGNKQGERVSSKEYDSEYGKKNESVYADFVYVSVSCEQINGNYFVHIYEEVDSHSKKDTPPSDSGAFNSESCHHNFEWVTVQEATAIADAVLAYECTNCGRVTDYMKEPNSAFAQFNKESIASIETAQKDAAVTLDTDIWNSFQGSVLSALSSRPDITLVIKYRYEGKRYTVTIPAGSDVLSLIDENGYCGFRTLDSQFGGNELTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K883</accession>
    <name>F7K883_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251769.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01856"/>
    <dbReference type="EnsemblBacteria" id="EGN41261">
        <property type="protein sequence ID" value="EGN41261"/>
        <property type="gene ID" value="HMPREF0994_01856"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2033"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="446" mass="48700" checksum="6EC899D16285580C" modified="2011-09-21" version="1">MLYSNKDLKKLIIPLVIEQTLAIAVGMADTIMISVVGEAAVSGVSLVDTVNILLINIFSALATGGAVVAGHFLGQKHPEEASKAAWQIIMFATTLALAISVLFIGFHDQLLRLIFGKIDTDVMQSAKTYLIITAVSFSGLAIYNSCAAIFRSMNNAKVTMWISLLINAINITGNAICIFGLKWGVAGAAIPTTVSRFVGAIVIFCMMFNPKKPINFCGQIRFKFNGDLIKKILYIAVPNGMENSMFQLGKIMVLSAVATMGTSAIAANAVANTLASWNILAGQAINLALVSVSAVCVGAGEYKQARYYTRKLMAITIGVTAVISVIMYVSMPVLVKMYSLGPEAAKMATDVMRFHNIMVVLFWVPSFTLPNTLRSAGDVIWTMVIAILSMWIFRVGASYLFTYQFGLGLLGVWGAMVIDWVFRAICYIWRYRGHKWETAMNRQREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8B3</accession>
    <name>F7K8B3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251799.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01886"/>
    <dbReference type="EnsemblBacteria" id="EGN41291">
        <property type="protein sequence ID" value="EGN41291"/>
        <property type="gene ID" value="HMPREF0994_01886"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2067"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="207"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="309"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="643"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="723" mass="81283" checksum="0C64B031A84D01D1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8E4</accession>
    <name>F7K8E4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252037.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02124"/>
    <dbReference type="EnsemblBacteria" id="EGN41031">
        <property type="protein sequence ID" value="EGN41031"/>
        <property type="gene ID" value="HMPREF0994_02124"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2326"/>
    <dbReference type="eggNOG" id="COG3935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053821_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046059">
        <property type="entry name" value="DUF6017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19481">
        <property type="entry name" value="DUF6017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6017" evidence="2">
        <location>
            <begin position="174"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="290" mass="33438" checksum="1D067593FE778823" modified="2011-09-21" version="1">MAVFRVEKTKDFTVMSNHHLRNTELSLKAKGLLSLMLSLPEDWDYTTKGLAHICRDGVDSITTALKELERHGYLTRQRLRNENGQLGDIEYTIHEKPVTGVKQGVSPKRENPRQVNPRQAKPEQAEPEQENPAQLNTNPQKTKKSKTDISRTHQSIYPEEPETAGCQDGIDRMDMAEAYRGIIKENIEYDFLVPRYGQERMDETVELMLETVLSRRPYIRIAGDDFPREVVRSRFLKINSDHLEYVFDCIDKNVTKVNNIKAYLLAALYNAPATMDSYYRAEVNHDLYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8K6</accession>
    <name>F7K8K6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002593311.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02194"/>
    <dbReference type="EnsemblBacteria" id="EGN41101">
        <property type="protein sequence ID" value="EGN41101"/>
        <property type="gene ID" value="HMPREF0994_02194"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2400"/>
    <dbReference type="eggNOG" id="ENOG502Z8X6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920426_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="37081" checksum="055A8C414B320BA1" modified="2011-09-21" version="1">MFDDPERYEHDGFYEEDTDYEDEYEADDSDYIVDDEENENALWDDEEEEPADDLPEKKRRKRKNQVVLADNDTDTEETELSEQVRRQITKEKQLIEELEADAEEHPFEDGTDEEELERKKLKRELRAEALARLEDSARTQREFENVIAWWDRLDANRERRERYHELSRSGDDVPLDYGASANELFFPDTLNDVLEKQIRKGDFIDAIFYCPYDIHELVTEEYLSKILWELTEEHKELLFLCAVRLFSSIRIAKIRNQSDRNIRKVRGTMLKKIRKKLLPALLDKVEKQQPMTLLEKDFLEESRMEIDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8N2</accession>
    <name>F7K8N2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252121.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02220"/>
    <dbReference type="EnsemblBacteria" id="EGN41127">
        <property type="protein sequence ID" value="EGN41127"/>
        <property type="gene ID" value="HMPREF0994_02220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2424"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="229"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="476" mass="50210" checksum="BC982CCD3AE4D437" modified="2011-09-21" version="1">MSITSQASQRITALLDDNSFVEIGAMVTARATDFNLKQTETPSDGCITGYGVIDGNLVYVYGQDASVLGGSIGEMHAKKIAGLYDLAMKTGAPVIGLIDSAGLRLQEATDALNAFGEIYKKQTMASGVIPQITAVFGTCGGGLALFPALTDFTFMEEKKAKLFVNTPNALAGNEISKCDTSSAAFQSEEAGIVDFVGDEAAILGQIRDLVCMLPSNNEDDNSFVECADDLNRADASLANCVGDTSIALSTIADDNAFVEVKAAYAKEMVTGFMKLNGVTVGAVANRSEVYNEEGENAETFDAALSPAGCEKAAEFISFCDAFNIPVLSLTNVNGFKADKCSEKKIAKAAAKLTYAFADATVPKVNVIIGKAYGSAYVAMNSKAIGADMTYCWPNAEIGTMDAKLAAKIICDGQGADAVNECAKEYAYLQTSAVSAAKRGYVDAIIEPADTRKYVIGAFEMLFTKREDRPAKKHGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K969</accession>
    <name>F7K969_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RelB/DinJ family addiction module antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252313.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02412"/>
    <dbReference type="EnsemblBacteria" id="EGN40811">
        <property type="protein sequence ID" value="EGN40811"/>
        <property type="gene ID" value="HMPREF0994_02412"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2642"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154558_16_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="89" mass="9965" checksum="4CA86C481FE1DFC7" modified="2011-09-21" version="1">MAQSTITARVDEKDKVNFDAFCSNVGLNTSTAINLFVKAVLRENRIPFEITQAVDPFFSESNLAYVKKSVQELREGKGTAHELIEVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9H0</accession>
    <name>F7K9H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252432.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02531"/>
    <dbReference type="EnsemblBacteria" id="EGN40930">
        <property type="protein sequence ID" value="EGN40930"/>
        <property type="gene ID" value="HMPREF0994_02531"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2776"/>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050833_0_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="32671" checksum="3F651149DD92F77B" modified="2011-09-21" version="1">MSIDKINLLVSFDENYILPFWTMIKSVSVNNPGEYFRVFLLHSAIPQEKLDWLIDGCVALGVRLTPLEVDRKLFQKAPVSERYPQEMYYRLLAPYLLPEEVGKVIYLDPDILVINRLRPLWTLDLKDCAFAAASHVGVTNIMNGINRVRLDTEHDYYNSGVMVIDLKKALPLVNPEVIFDSVRVHASELLLPDQDVFNYLYGAQTMPLEDEIWNYDTRCFSDYLLRSKGIYSMGWVIQNTVILHFCGKKKPWTENYTRQFNALYKHYMRLAALEANPYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9H8</accession>
    <name>F7K9H8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252440.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02539"/>
    <dbReference type="EnsemblBacteria" id="EGN40938">
        <property type="protein sequence ID" value="EGN40938"/>
        <property type="gene ID" value="HMPREF0994_02539"/>
    </dbReference>
    <dbReference type="GeneID" id="29723354"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111921_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="206" mass="24423" checksum="541D2ACB74187A1E" modified="2011-09-21" version="1">MNIKEAERMTGLKKANIRYYEQEGLLQPKRNGQNNYREYDQQNIETLERIKLLRLLEVPVFQIQALQKGETTLHNVIDLQEKKFSEEIREKEELLKLCKRVKMDCSNFESLTVIASEGNGEYWHRMNGKILCQDKIRRIEARMALLKNSLPLLMLSYWIVWTTYRIADHQLPAEFTAIYIILTLAVLGLWCLLRLKVSHEKCTYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9I3</accession>
    <name>F7K9I3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">sn-glycerol 3-phosphate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02544"/>
    <dbReference type="EnsemblBacteria" id="EGN40943">
        <property type="protein sequence ID" value="EGN40943"/>
        <property type="gene ID" value="HMPREF0994_02544"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2788"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513754_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356746" evidence="2">
        <location>
            <begin position="28"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="533" mass="59218" checksum="91E5D3BAB86F15B6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9N5</accession>
    <name>F7K9N5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252412.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02511"/>
    <dbReference type="EnsemblBacteria" id="EGN40910">
        <property type="protein sequence ID" value="EGN40910"/>
        <property type="gene ID" value="HMPREF0994_02511"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2752"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030827">
        <property type="entry name" value="Myo_inos_IolG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04380">
        <property type="entry name" value="myo_inos_iolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="336" mass="36754" checksum="8C3AC92E17B4AD88" modified="2011-09-21" version="1">MVKVGIIGAGRIGKVHITSISTRVRDAVIKTVADPFMNEETAAWAKGMGVQHTTKDYEEIIRDPEIDAVLICSSTDTHSPISLEAIRAGKHVFCEKPIDHDVEKIKEVAAALEGTKVKYQVGFNRRFDHNFEAVQRAVAEGRIGRPEIIKITSRDPEPPGIDYVKVSGGMFLDMTIHDFDMARFLAGCDAEEVYVQAANLVDPKIGEAGDVDTAVITLQMENGAIAVIDNCRKAVYGYDQRAEVFGSEGMAAIGNDSQSSVQISNSDGVTGEKPLFFFLERYMDAYGKEIAAFIDAIVNDTETPLGVMDGLKPVLMGLAAKKSWEEHRPVKISEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9R9</accession>
    <name>F7K9R9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02600"/>
    <dbReference type="EnsemblBacteria" id="EGN40583">
        <property type="protein sequence ID" value="EGN40583"/>
        <property type="gene ID" value="HMPREF0994_02600"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2933588_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="63" mass="6900" checksum="74D391F4028E7A8F" modified="2011-09-21" version="1">MNSDPVTITGKNGNNAVLISEADWKNIQETIYLNSVLGLAESIIAGSKEPIDECKEYAEGEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA12</accession>
    <name>F7KA12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02695"/>
    <dbReference type="EnsemblBacteria" id="EGN40678">
        <property type="protein sequence ID" value="EGN40678"/>
        <property type="gene ID" value="HMPREF0994_02695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2949"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="472" mass="51109" checksum="B45B400B1563C6E3" modified="2011-09-21" version="1">MEQQMNETGMKKKFNLAALFAPTDMTEGSPGKRIVAFAIPMLIGNIAQQLYNTVDSIVVGRYVGDNALAAVGSASPILNLLLVLFVGISVGASIMVSQYFGAKQREELSGSIGCSITLTAISSVIIMILAPLVVRPLLRLLNTPDSIMDWCASYLIILFVGIAGMSYYNILSGILRGLGDSVSALVYLLVATVLNIILDILFVAVFDMGVAGVALATAIAQAVSAVMCIFKLARMKDIFDLKLHYLKPEKKHSADMIRLGLPSGFTQAIFSMAMIIVQSLTNSFGEMFIAANVIIMRVDGFAMMPNFSFGTAMTTYAGQNVGARKYDRVEKGAREGTIIAAVISAVITSLILIFGKYLMGIFTETKELVELSMHLMQILAVGYIAMAVTQCLSGVMRGAGDTMTPMWISLITTVAIRVPLAYGIAWMTRTPELPNGRNECVFISLLCSWVLGAVMTYFFYRKGAWKKKALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAW7</accession>
    <name>F7KAW7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enolase</fullName>
            <ecNumber evidence="9">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eno</name>
        <name evidence="14" type="ORF">HMPREF0994_02996</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
        <text evidence="9">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252897.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02996"/>
    <dbReference type="EnsemblBacteria" id="EGN40316">
        <property type="protein sequence ID" value="EGN40316"/>
        <property type="gene ID" value="HMPREF0994_02996"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3273"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="13">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="12">
        <location>
            <begin position="141"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN40316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="434" mass="47398" checksum="BC19816E4CCD5A57" modified="2011-09-21" version="1">MHLYLEITDVHAREILDSRGNPTVETEVTLENAVTGRAAVPSGASTGQFEAVELRDGETRYFGLGVQKAVKNVNTKLKAALLGKNALCQLEIDRILMDADGTDNKSNLGANATLGVSMAVAKAAAKALEIPLYQYLGGIHARQLPVPMMNILNGGKHADNTVDLQEFMIMPVQAESFRDGLRICAEIYHNLKKICKDRGLSTAVGDEGGFAPNLGSSSDVLRLIVEAVKASGYTPGQDIKIAIDAAASELYDEKSKRYYFPGESRMSGQEVYRDSEAMVEYYEELVREFPILSIEDGLFEDDWDGWKMLTARLGDKVQLVGDDLFVTNTKRLDAGIKLGVANAILIKVNQIGTLSEAFEAISMAQKNGYKTIISHRSGETEDTTIADIAVAVNAGQIKTGAPCRTDRVAKYNQLLRIEEELGYAACYKEPFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAZ3</accession>
    <name>F7KAZ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="11" type="ORF">HMPREF0994_03022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03022"/>
    <dbReference type="EnsemblBacteria" id="EGN40199">
        <property type="protein sequence ID" value="EGN40199"/>
        <property type="gene ID" value="HMPREF0994_03022"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3301"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="477" mass="53251" checksum="77AE10074ED338F1" modified="2011-09-21" version="1">MGMLRFFAYERSPARKGGRWLPGRNTQAFPTDKSPDRKEGIRMNYATQMEAARRGILTEEMNAVAAKEKIPAAQLVSLMAEGKVIIPCNKRHKSLEPNGLGSMLKTKINVNLGTSRDMTDLEMEYEKVHRAVEMGAEAIMDLSSFGDTRKFRRYLTENCPAMIGTVPIYDAVVYYHKPLKQITAREWIDIVRMHAEDGVDFMTIHCGINRETAHKFKKNKRLTNIVSRGGSIIFAWMEMTGEENPFYEFFDEILEICREYDVTLSLGDACRPGCLADATDASQIEELITLGELTERAWKKAVQVMVEGPGHMPLNQIAANMEIQKTLCHGAPFYVLGPIVTDVAPGYDHITAAIGGAAAAAAGASFLCYVTPAEHLRLPDVEDVKEGIIAARIAAHAADIAKGVPDAMEWDNSMSAARKKLDWKEMFRLAMDPEKAERYRETSMPEKEDTCSMCGNFCAVKNMNRILDGEIVSIFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB38</accession>
    <name>F7KB38_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252969.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03068"/>
    <dbReference type="EnsemblBacteria" id="EGN40245">
        <property type="protein sequence ID" value="EGN40245"/>
        <property type="gene ID" value="HMPREF0994_03068"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3353"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_4_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010087">
        <property type="entry name" value="Flav_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01753">
        <property type="entry name" value="flav_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="145" mass="15442" checksum="9AE34A69E44B57DD" modified="2011-09-21" version="1">MAQISIVYWSGTGNTELMAQKVAEGVREAGQEAVVLSVDLADVSELKKARAFALGCPSMGAEQLEETQMEPFMCDLENGIGGKQIGLFGSFGWGGGEWMRDWEERVRNAGASVVGEEGIIVNGAPDEETEEKCKELGRALAAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBL8</accession>
    <name>F7KBL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253156.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03255"/>
    <dbReference type="EnsemblBacteria" id="EGN40085">
        <property type="protein sequence ID" value="EGN40085"/>
        <property type="gene ID" value="HMPREF0994_03255"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112419_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="24979" checksum="00E0E880FFDC60FD" modified="2011-09-21" version="1">MYEEIPDLNLFMVCEVPKKEAFACLPEGYYFDSCRRNELDLWKRMPFDEEEQAEAFFGYMTDYFQKVYGEKEDLFYSQCLFVRDGEGNPVGTGFIWKSYGKINTLHWLKVKKGCEGSGIGRAIITKLLSELETNDFPVYLHTQPSSYKAIKLYTDFGFAFLTDKKIGYRENGLEESLPVLMRYMPEEDYKRLRFRTAPESFLEAVLSSEINEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC15</accession>
    <name>F7KC15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39901">
        <property type="protein sequence ID" value="EGN39901"/>
        <property type="gene ID" value="HMPREF0994_03394"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3201191_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="45" mass="5077" checksum="2C0F7B1138AF5623" modified="2011-09-21" version="1">MKGMGPYDCGKTPLLMAEAEGTVVMHAVHHRYHQLSVRILKYHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC32</accession>
    <name>F7KC32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39918.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03411"/>
    <dbReference type="EnsemblBacteria" id="EGN39918">
        <property type="protein sequence ID" value="EGN39918"/>
        <property type="gene ID" value="HMPREF0994_03411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041527_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="202"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39918.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="409" mass="46583" checksum="79093E468FA89675" modified="2013-09-18" version="2">MEYIKRNMEEIFLELNKQYPAILVTGPRQVGKTAMLQKLIVLEGRSRNYVSLDDLNDRALAKTDPAMFFQIHQPPILIDEIQYAPELFTYIKIYADRDQRAGDFWMIGSQLFKLMDGVQESLAGRVALLHLSPLSQQEIYSGQAGAFSLDIDVLSKRQQVVRPALAPQIFDRIFLGGMPALVSKKYQERSIFYSSYINTYLERDVKDLSGSIDSLKFLNFITAVAARTSQMVNYKGIADDCDMDQATVKSWLRILETLGIIFYLHPYSNNVLKRTVKTPKIYFYDTVLVCYLTKWSSSETAMSGAMNGALLENYTVSEIQKSYQNVGKEPYLYYYRDKDAKEIDLLMEGDGQLHPIEIKKTATPEKKMISNFSVIEKSFMQRGIGAVLCLSEKLGAFDKDNLIVPISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCE1</accession>
    <name>F7KCE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253421.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03520"/>
    <dbReference type="EnsemblBacteria" id="EGN39429">
        <property type="protein sequence ID" value="EGN39429"/>
        <property type="gene ID" value="HMPREF0994_03520"/>
    </dbReference>
    <dbReference type="GeneID" id="29728794"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="213"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="34386" checksum="835532D88577B26F" modified="2011-09-21" version="1">MTEVYLITGFLGAGKTCFVKNMVKALPHEIMDIIVNEFGREGIDGALLHKTGLQVKEIVNGSIFCTCRLDQFEEALASSLSRKPEAILVEASGLSDPMNIRRVLDSVDGSGKLHYAGAWCLVDALNFPKVYQTAVAVKKQLAVSDVFIVNKTDLASEAVLQKTLGILKEARPECPVYSTSFGQVQPRWILPVEVPEAERGGRGIYQMDITNKSYLLEIKDSFAKQEFEAFLDRFIRDTYRVKGFVRLEGRLYLADCTSDRRQLLPWEMLPGEKEPEGINRVVILGGSGLPTAGSVKKACLGFEDKIISFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCE7</accession>
    <name>F7KCE7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253427.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03526"/>
    <dbReference type="EnsemblBacteria" id="EGN39435">
        <property type="protein sequence ID" value="EGN39435"/>
        <property type="gene ID" value="HMPREF0994_03526"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="288" mass="33779" checksum="113D33BCAB921092" modified="2011-09-21" version="1">MNPVEKELTGLLADERYGTFIQTIRKIRFPANYRFDSHAHPQVEINYINSGCCMMEVEERIVPLKRGSCIVVNPGQKHLFMVDVSKSCAITQLIYRTALPEKIPESLTCFHYDRPFYVFQDCGELCSLLENIGRYYQRRQEDDYQEAQLDFSLLQLYAMLSRSMEKERLQADSRQGKLGEALDRIHSRLEEDINIEELSRELGMSSRYLRKAFEDSIGISCSQYITMLRIARAKELLWDWEKDITQVASLTGFNSPQYFCRIFKKHTGMTPAQYRNMKKERLELTEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCK6</accession>
    <name>F7KCK6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253493.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03592"/>
    <dbReference type="EnsemblBacteria" id="EGN39501">
        <property type="protein sequence ID" value="EGN39501"/>
        <property type="gene ID" value="HMPREF0994_03592"/>
    </dbReference>
    <dbReference type="GeneID" id="29728996"/>
    <dbReference type="eggNOG" id="COG4758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081309_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="239" mass="25927" checksum="6932FADF3C1F23AD" modified="2011-09-21" version="1">MKKKNVFWGLLFILGALAVLVSKLGVFEGVGFWSVLFSIGLIGILINGIIHRSWGTILFSTAFLAIVNSALLGIEKLVPWPVLGAALLGTIGLNMLFPSRHHHGHYVYNGGIGGEVGEVEYHEEVSNDGSEQVNCGVSFHSSVKYIQCTQLKSLNLDSSFGGLTVYLNNAVLKGHEAFVNVDVSFGNLELYIPAGWRVICNVSSSFGSVQEHGRCRGEEADMLTINGEVSFGTLDIYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCK7</accession>
    <name>F7KCK7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253494.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03593"/>
    <dbReference type="EnsemblBacteria" id="EGN39502">
        <property type="protein sequence ID" value="EGN39502"/>
        <property type="gene ID" value="HMPREF0994_03593"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3926"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106729_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="153" mass="17690" checksum="EBBB4D835413877B" modified="2011-09-21" version="1">MRVRIEIEPELPEDEVIIRCRKVEEHILKLQQMAVDSGPGDSCIALQSGDTKYYVPLAQLLFFETEGKLVQAHTADRLYLTDRKLYELEESLPGSFMRISKSTIVNLDHIYSITRNLTASSIVEFYGTAKKVYVSRNYYKALTERLGEKRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCR6</accession>
    <name>F7KCR6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03645"/>
    <dbReference type="EnsemblBacteria" id="EGN39017">
        <property type="protein sequence ID" value="EGN39017"/>
        <property type="gene ID" value="HMPREF0994_03645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3977"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291479_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN39017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="995" mass="113014" checksum="11E3DF004EAA988E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCV5</accession>
    <name>F7KCV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253585.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03684"/>
    <dbReference type="EnsemblBacteria" id="EGN38965">
        <property type="protein sequence ID" value="EGN38965"/>
        <property type="gene ID" value="HMPREF0994_03684"/>
    </dbReference>
    <dbReference type="GeneID" id="29728346"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4021"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027430_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="4">
        <location>
            <begin position="37"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5597" evidence="5">
        <location>
            <begin position="382"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN38965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="558" mass="62566" checksum="77F1E4BA1A8CB3CF" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCX9</accession>
    <name>F7KCX9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03708"/>
    <dbReference type="EnsemblBacteria" id="EGN38872">
        <property type="protein sequence ID" value="EGN38872"/>
        <property type="gene ID" value="HMPREF0994_03708"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4048"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="354"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN38872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="50273" checksum="9C8A0E2F10E9877F" modified="2011-09-21" version="1">MFEYQNEHYENRNQMYNYNGMPENGPAEPHKPSASPNPGHTGKKARILKKAGAITLSAILFGGVAAGSFQAVNYLTGYQTPTAESAAASAGTNTASLLQTASLPSTADGKGSLDVSDIAQAVMPSIVSITNKSVQEVQNYFSLFGYGYSGETIPQETESRGSGIIIGKNDTELLIVTNYHVIADADTLSVAFNDNQVYEANTKGTDPDNDLAVIAVPLESISADTMSQIAVASIGDSDSLKVGEQVVAIGNALGYGQSVTTGIVSATNRTLNSNMNTANTSEDSADQPAYIQTDAAINPGNSGGALVNMKGEVIGINSAKLASTEVEGMGYAIPVSRVSDIIEKLMNETTRSKVSEDQKSSIGITGITVTESVNSVYGIPSGVYVAGVTEGSGAEKAGLRKGDVITKFDGKNITQIQELTELLQYYPAGETVELTIQTIGSDNAYTEKTVSVTLGHAVNSGSQSGSSGQPEANAQKDMSAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD71</accession>
    <name>F7KD71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38771.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03800"/>
    <dbReference type="EnsemblBacteria" id="EGN38771">
        <property type="protein sequence ID" value="EGN38771"/>
        <property type="gene ID" value="HMPREF0994_03800"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38771.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="33388" checksum="8BE5AF95E22389C2" modified="2013-09-18" version="2">MMLKKKKKRNWTLHLMMMPSVAALIVFSYIPMAGIIIAFQKFNPGFGLFGASPWVGLDNFHYIFSLPSIWQVVGNTLILSVAKIIIGTILAIATALLLNECRHRLLKKSVQTIIYFPYFISWIIMAGILADMLSPTKGVINQLITSIGGTPVYFLGDNRYFRGTLIISDIWKNFGYNSVVYLAAITGIDMSLYEAAAIDGAGRWKQTLHVTLPGMSVIIILMVILNMGNLLNAGFDQVFNLYSPGVYESGDIIDTMVFRLGIQQGQLSPSTAVGLLKSGVSLLLISLSYYIADKKFDYKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDH1</accession>
    <name>F7KDH1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38673.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360307.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03908"/>
    <dbReference type="EnsemblBacteria" id="EGN38673">
        <property type="protein sequence ID" value="EGN38673"/>
        <property type="gene ID" value="HMPREF0994_03908"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="376"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38673.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="56155" checksum="E8B13A94AD93772D" modified="2013-09-18" version="2">MYKILIADDERWVLLGIKQLLEKINLPFQVVGMAENGIEALEMLVELQPDVLITDIRMPGMDGLELMEKMNACEIDSKVIFLSGYAEFDYVQKAIHLGALDYLLKPIDENRLKSVLDAVLDRLYKEQDDDSKLLYLEKVFNVQADCFYKKLDSGEESLQLVYQCMSLLLEEEWNGEKNGLMEQNHFFYFTLSREKNRIVVFLKYPEKLKQKSVLKLIKDIFPGIRAIGFSGKSYNGDNLIELMEESNIALCTEDFCYGHGEMDFSKNREVGRKKLKEYLCYMNQALEEKNINQLRILFHELEKEMKEGRVYIDQLALLYNQLAIKLNTEGAAFEYFNYYQIDIQFSEIEKFFEYVKQEVENSFQEEGYVTNSLLYSIVMKVKSESIDNTIALGELAEEFGVSRGYLSNILKKELGMPFSEYLIGKRIQKAKELLLDDKLSIEEIAEKVGYNDYFYFLKAFKKNTGTSPSKYRKSILEKILPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDJ1</accession>
    <name>F7KDJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38701.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360311.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03936"/>
    <dbReference type="EnsemblBacteria" id="EGN38701">
        <property type="protein sequence ID" value="EGN38701"/>
        <property type="gene ID" value="HMPREF0994_03936"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339ND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722887_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38701.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="397" mass="45950" checksum="69AFA80E4613BAB5" modified="2013-09-18" version="2">MSWYAGTFYCGHEGYVNIIGPASNREKMKEYKFSGLCPACCKAELIRSRNEKNTAARKAASRMELPPLEGTRKQVVWAETLRVEALTRLQTFIDTPGNIHLIILRLNYEALTPLELTEENLPPMLQEIVQYLIHEKVKAAYWINNRFNRELCNLEQLIPEYLEWCKWYRPEQTVSESDFIRSDSVLSPKNPQFPGIVEIKGNDEEISAFYEKNDRFREIIRQMDYEWNGRCWFRRLTPYRGSFRDRAAELGNVLLKNGFTVSITDKEAREGAVNGDFSPEHKRWITKSKKGLFFFIPLSSSIPREVVLNLKKIPTAAYHSGGIFLEPSHYEELEDFAEMYGFRFDREAGELLHAYRDTLQQVPHVSPAAPQPSEEINNLHKILESSGAILDDLVDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDZ3</accession>
    <name>F7KDZ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253973.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04072"/>
    <dbReference type="EnsemblBacteria" id="EGN37108">
        <property type="protein sequence ID" value="EGN37108"/>
        <property type="gene ID" value="HMPREF0994_04072"/>
    </dbReference>
    <dbReference type="GeneID" id="29729512"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4443"/>
    <dbReference type="eggNOG" id="COG3212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067057_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363691" evidence="2">
        <location>
            <begin position="27"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="177"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="26140" checksum="B72F3772E929CBF8" modified="2011-09-21" version="1">MKRNLYILLPALGLSAALLAACGSQSTPDSVTQQITSNQDALAAGASSSTVQITENKDDDASLPAAGETVPLAANASLQAAADSGQTAYISEADAKKIAMEHAGVKEEDISYFKLKLDTDDGIVEYDIKFYVGNTEYEYDIDAVTGTIRSFDTELSEEHHQNGTQGSSNAAAPAGSISEADAKKIALEQVPGATENNLRLKTDYDDGRMKYEIKIVYNEIKYEFDIDAATGKILEWESESIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE05</accession>
    <name>F7KE05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253985.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04084"/>
    <dbReference type="EnsemblBacteria" id="EGN37120">
        <property type="protein sequence ID" value="EGN37120"/>
        <property type="gene ID" value="HMPREF0994_04084"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4457"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN37120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="27284" checksum="2218B906F3E30FB5" modified="2011-09-21" version="1">MAMLDVTKLSISFGGLRAVDELTMQIEEGGLVGLIGPNGAGKTTVFNMLTGVYLPTEGGIRLDGKNLIGKKPADICKMGVARTFQNIRLFPKLSVLDNVKAGLHNQVTYSLAESMLHLGGYSKKEKDMDQRALEILSVFGLDSSANDLASNLPYGKQRKLEISRALATSPKLLLLDEPAAGMNPNETGELMETISLVRKKYGVTILLIEHDMKLVQGICEYLYVLNFGKLLAEGTPAQVLNDPAVIKAYLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE32</accession>
    <name>F7KE32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254012.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04111"/>
    <dbReference type="EnsemblBacteria" id="EGN36904">
        <property type="protein sequence ID" value="EGN36904"/>
        <property type="gene ID" value="HMPREF0994_04111"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4484"/>
    <dbReference type="eggNOG" id="COG3214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043035_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="406" mass="47125" checksum="D6AC473CF7A39B28" modified="2011-09-21" version="1">MLTLTNKQARQFILLKHGLLGTHKFVGKQGALEFVRQAGCIQFDPVDSCGKNAELTLQSRVNNFTKQTLSELLYTDRSLVDFPDKNLSIFTTEDWPYFQRYRQAAKDGGRNFPELEELEKQAIEYIRINGAVSSDDLPMQGSIHWHSSIHWSGVWNGNTNAARAVLEQLYSTGILIIHHKNGSRKYYDLADKYLPAQLLDSPDPLPDDFAHKKWRVLRRIGAVGLLWNRPSDAWLNIWDMKSPERIQIFKELLSEGKILAVQVEGISAELYYRAEDHPLLETVLENRDYKPRCEFLAPLDCFLWDRKLIKALFGFEYSWEIYTPASKRKYGFYVLPILYGDRFAGRIEAVCQSKTNVLLVKNIWYEDGVRQTKKLLSEINKTLKRFARFNQCDSIQFETPDRQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KER8</accession>
    <name>F7KER8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254248.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04347"/>
    <dbReference type="EnsemblBacteria" id="EGN35657">
        <property type="protein sequence ID" value="EGN35657"/>
        <property type="gene ID" value="HMPREF0994_04347"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503325S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100928_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="228" mass="24932" checksum="F995BBCBAFE5F295" modified="2011-09-21" version="1">MINLLKAEYYKLLHKQSFWGLLFFSLALGSLLLTDSKNTTSDLVKGSLYNLPQIYFISILFAALFIGEDFENRTISSFISAGHKRGAVFFAKALSYLTASTALLAVPVLFHSAAAAILGKTAILSFSNMLTLFMAVPAMGMLPLLFAFLFRDIGKTFVIPMVLYFLMIFALNSSRAAQLAVLLPIGQIRLISLNQLTSPTAVTAGIDGVWIFLSGLLAYGSFCRCDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF03</accession>
    <name>F7KF03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_04440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254341.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04440"/>
    <dbReference type="EnsemblBacteria" id="EGN35750">
        <property type="protein sequence ID" value="EGN35750"/>
        <property type="gene ID" value="HMPREF0994_04440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4849"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="561"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="795"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="933"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1059" mass="121144" checksum="CEA89C6458D1B193" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF49</accession>
    <name>F7KF49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04491"/>
    <dbReference type="EnsemblBacteria" id="EGN35801">
        <property type="protein sequence ID" value="EGN35801"/>
        <property type="gene ID" value="HMPREF0994_04491"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3008511_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="56" mass="6786" checksum="B62EB7C3DE91F38B" modified="2011-09-21" version="1">MENGILIDKKYAIICYYKECEMKQILICRWQAQELEWVELEKRSSSNVKRDAFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFB6</accession>
    <name>F7KFB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04545"/>
    <dbReference type="EnsemblBacteria" id="EGN35314">
        <property type="protein sequence ID" value="EGN35314"/>
        <property type="gene ID" value="HMPREF0994_04545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4962"/>
    <dbReference type="eggNOG" id="COG3395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044742_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="71"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="338"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN35314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="517" mass="56816" checksum="0C3F64CAE439675E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFF9</accession>
    <name>F7KFF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254489.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04588"/>
    <dbReference type="EnsemblBacteria" id="EGN35035">
        <property type="protein sequence ID" value="EGN35035"/>
        <property type="gene ID" value="HMPREF0994_04588"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5008"/>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="31111" checksum="5C1CB962D3AA63BF" modified="2011-09-21" version="1">MNPLIFQSDFGRADGAVSAMYGVAYSVCSDLKISDLTHEIPQYDIWEASYRLIQTVSYWPEGAVFVSVVDPGVGSTRRSIVARTEGGQYVVTPDNGTLTHIKKLCGITEARVIDETVNRLPGSGESYTFHGRDIYAYTGARLASGIIDFEGVGPEVPVDSVVEIPFEPARLQENEVSGTIDVLDVRFGSLWTNIPRKLFLQMGVAHGDRIEVIIEKRGHTVYRTSLIYAHSFADAFIGEALVYVNSLDFMAVAINQGNFARAYNVGTGLSWRITMRKSTLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFJ0</accession>
    <name>F7KFJ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254520.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04619"/>
    <dbReference type="EnsemblBacteria" id="EGN35066">
        <property type="protein sequence ID" value="EGN35066"/>
        <property type="gene ID" value="HMPREF0994_04619"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9TS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102870_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="232" mass="25461" checksum="63447231D45F1EA7" modified="2011-09-21" version="1">MLKLMRLEAQRINLRVYFLTALILGGILLLFAYFTANAARVTGETEFMTYRNILQFTCVISLLLFSILAAVMYNNVVIKEYSGKRLSLLFSYPSDRKKIFMAKIIMVFSLIFGLMLLCTVIPAAIFLITESFAPTIEDTITAGLLLSTFGSILAAVLFANTIGIFAMGIGFIKKSVTAALIAAFVLFGIYGNITIITGNSPFMALLAAGISIFTVIIILVMLADKIKRMEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFL6</accession>
    <name>F7KFL6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254546.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04645"/>
    <dbReference type="EnsemblBacteria" id="EGN35092">
        <property type="protein sequence ID" value="EGN35092"/>
        <property type="gene ID" value="HMPREF0994_04645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5073"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="87"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="326" mass="36518" checksum="F98303201ED866B5" modified="2011-09-21" version="1">MKKETLAVWQEGEYSYPLAFGFVPNLVSYIHEEDTQERPCMLVVPGGGYCVVSPTEGEIVAMEFYEKGYNAFVFTYTTNPLMLEPLKDQSMRDLSRAIRLIRSRAGEFHIDPGRLILCGFSAGGHLCASVCVHYMDVEDGRYGSFSNRPDAAILSYPVITSADKAHRGSFQALLGMDAAEEELEYMSLEKQVSPQTPPCFLWQTATDEAVPVENSYLFAEALKENGVPFAHHVFSEGRHGLSLANEKWANGEYGEPYTMEQTLKIAENVKNGNIQVSEEVKESFLPQFERSEEETKALLAENSPNDEVAVWPVLAHQWIKAVLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFN7</accession>
    <name>F7KFN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04666"/>
    <dbReference type="EnsemblBacteria" id="EGN34877">
        <property type="protein sequence ID" value="EGN34877"/>
        <property type="gene ID" value="HMPREF0994_04666"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5097"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="8">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="38"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="28721" checksum="9370C8F9B6046992" modified="2011-09-21" version="1">MINQDNVQFSDYTISGGILEALKALGYNSPTNIQKEVLPVLLAGKNAVVKAPTGSGKTAAFAIPICESIEWEENAPQALVLEPTRELSVQVSDEIFHIGRKRRLKVPAVFGGFPVDKQIQTLRQKSHIVVGTPGRVMDLVRRDSLKLDKIKWLILDEADLMLDMGFVDEVKEICALIPKGCRISLFSATLKPEIQELVDEFIRDMVPIIVENTEESAGSIEQKAYRADGEDKYHTFLHVLMDENPESCIIFAERGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGN9</accession>
    <name>F7KGN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254919.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05018"/>
    <dbReference type="EnsemblBacteria" id="EGN33813">
        <property type="protein sequence ID" value="EGN33813"/>
        <property type="gene ID" value="HMPREF0994_05018"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5481"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN33813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="324" mass="36315" checksum="F8847CF4F7320B5B" modified="2011-09-21" version="1">MAVRTTGEKGRVMKNQPNAKKSMGKRISVEVKRHWQLYLMLVLPVAYLIIFAYLPMGGAVIAFKDYSIRGGIWGSEWVGLKHFKNFFTTPDFKNLMTNTLALSLYSLIISFPMPILLALAINEMRGRHYKKVVQMVTYLPYFISTVVLVGIMQNIFSVRTGLVNNIIMLFGGKAVDFMGKPGLFRSLYVWSGVWQGMGYSAVIYIAALASVDISQTEAAIIDGAGRFARVWNVDIPAIMPTIVIQLILAVGSIMSLGFEKVYLMQNPVNMQTSEIISTFVYKRGLINFQYSYATAVGLFNSVCNMVLIVLANMFSKRVNETSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH25</accession>
    <name>F7KH25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255062.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05161"/>
    <dbReference type="EnsemblBacteria" id="EGN33194">
        <property type="protein sequence ID" value="EGN33194"/>
        <property type="gene ID" value="HMPREF0994_05161"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5641"/>
    <dbReference type="eggNOG" id="ENOG502ZZ52">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130392_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="104" mass="11867" checksum="A48E3F74A65FAC4E" modified="2011-09-21" version="1">MELKFVIPNMEKTFGNLEFAGEDKTEQKRINGRMAVLSRSFNLYSDVQRADDIVVILPAEAGEKHFDFEERVKLVNPRITAEGYKIGARGFTNYILHADDMVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH97</accession>
    <name>F7KH97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002588985.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05236"/>
    <dbReference type="EnsemblBacteria" id="EGN33269">
        <property type="protein sequence ID" value="EGN33269"/>
        <property type="gene ID" value="HMPREF0994_05236"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5718"/>
    <dbReference type="eggNOG" id="ENOG502Z8IW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135497_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018546">
        <property type="entry name" value="DUF2004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09406">
        <property type="entry name" value="DUF2004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="167" mass="18980" checksum="B58DC0012FFDCE88" modified="2011-09-21" version="1">MKLNCKRIDFTYTPGEEIFNFPEESGLPFIFDVEEELTGDPAVMDAVGEMLDEAEKLAEKAKAAIKAALADEDSRYHSVVTFFMEFHRDDVGPDIVAELFPGTDPAKLSFAEMVDFLKLKRFGSLVDSEMNQQVFILDLSFNPEITDELMVIYFDLNKEIFCITHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHQ8</accession>
    <name>F7KHQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255236.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05393"/>
    <dbReference type="EnsemblBacteria" id="EGN32834">
        <property type="protein sequence ID" value="EGN32834"/>
        <property type="gene ID" value="HMPREF0994_05393"/>
    </dbReference>
    <dbReference type="GeneID" id="29727055"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5896"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="30782" checksum="FE4990CCC039A506" modified="2011-09-21" version="1">MSIRFICDSTCDYTEQQAKELGITLVPLKVLFGEKEYFDGVDIKPEAFYDMLADSEELPTTSQPSPEAFLQYFREAKEAGDDVICILLASKLSGTCQSALVAKDIVEYERIYIIDSMQATLGTQLLTERAFALQKEGKNAEQVVEILEKEKEKVCIYLIVDTLLYLQKGGRLSATGMVVGSALNLKPVLAVRYGEVKVAGLARGQKGAREKLLKAMEKDGGMDKSRGYNLGYTGNNEFLGEFQDFIRERLGTEYNKMVAVGSVIGVHVGPGASAIAVFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI37</accession>
    <name>F7KI37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05402"/>
    <dbReference type="EnsemblBacteria" id="EGN32843">
        <property type="protein sequence ID" value="EGN32843"/>
        <property type="gene ID" value="HMPREF0994_05402"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3081027_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="52" mass="5989" checksum="38016847FAD1EF91" modified="2011-09-21" version="1">MIRELMQYIVHMRPYIFTIGIIVAAGTIKIRFGIIVKADFIGHPHFSFLPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI85</accession>
    <name>F7KI85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05564"/>
    <dbReference type="EnsemblBacteria" id="EGN32389">
        <property type="protein sequence ID" value="EGN32389"/>
        <property type="gene ID" value="HMPREF0994_05564"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6080"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="350" mass="39317" checksum="4BD4C48CCB2BBCB2" modified="2011-09-21" version="1">MPKNTRGVQVKQIAEHLGLSSGTVSIVLNGRGDELRISKETQKIVLDTAREMNYQSGKNQKKNQKTAARREKFCIGVFWNLHYMGGLLGQFYSGFLETIKQYHAEVEIVLQPFEYDHLNLLEDAFSGKRYDGAIIGGLSEIDSGYLRENTFEIPIVLINQTLENYSSVYVDDYQTGRQCAELFCRNGHKRAGIVSSENRSAASVLRYNGFAEECRKCGIQLKDEWKVTGEGNGIGGYESVRQMLQCRELPTALFVQTSRMSSGILAALRDGNIEVPGQMEIIAYGDGDFSQYLYPTVTVLHVSVAEMAANAMHLVLTILQNDLHMTLSKLHVTKLIYGESFQEKPYERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI93</accession>
    <name>F7KI93_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05572"/>
    <dbReference type="EnsemblBacteria" id="EGN32397">
        <property type="protein sequence ID" value="EGN32397"/>
        <property type="gene ID" value="HMPREF0994_05572"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="331" mass="37537" checksum="9DFA19F3C2AAFC5E" modified="2011-09-21" version="1">MRKKAADTELSMEDIARTLGISITTVSRALSGKGRISTATRKRVLEYAETVQYSPNKFARALSGSRTFNIGVVIPGDAKMEEMSFFQDCLQGITEEGARNDYDILLIYTWGEDIRQLRKVISSGKVDGVIITRAVREDPAVCLLEETGLPYVVIGSKNEKKIIQGCCEMTGSLLDRGIKRLALIGGDIRHEVTISRYKGFKKAFWQRGLRPQEDIVLLNTLNREMAEEAVEYAVRGKAEGILCMDDCICRYVFQKLDRSSCRVPGDIKQASFYDNSLLVHHNPSITAIHFCDEERGRYECLELINRMEGRDFKSVPEVNYEIRFRESTDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIB0</accession>
    <name>F7KIB0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255396.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05589"/>
    <dbReference type="EnsemblBacteria" id="EGN32414">
        <property type="protein sequence ID" value="EGN32414"/>
        <property type="gene ID" value="HMPREF0994_05589"/>
    </dbReference>
    <dbReference type="GeneID" id="29728872"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6106"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="61"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="330" mass="37190" checksum="4FF5E8650F871A0A" modified="2011-09-21" version="1">MLDLIKLSGEETCVADEFKMDWENQGIDFYEDVAYGMGGDHPMYLDLMIPREKAEKKRPVIIWVHGGGWSIPELTKKYRPVNALVQACHMGFVCASIEYRLVTEKPFPAPVEDCKCAVRFLKAHAGELGIDPDCIGIWGESAGGQLAALVGASYKNPRLEGNGGWKEYSSEVKAVCDWYCGGDMTHMGAYACPQVQARAKELGIRLTLMPGQQGKEEKQRDEVQEKIFVQMFGRPGREAPELSMEISPIFYVDQKQPAYLLMHGDSDQAVSPEFSYNYYDALLKYGHDATFVLVPRQGHGFFKGQGYYDIVLDFFRKKLVPCADDRKEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIG4</accession>
    <name>F7KIG4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_rhamnosid6H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255450.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05643"/>
    <dbReference type="EnsemblBacteria" id="EGN32267">
        <property type="protein sequence ID" value="EGN32267"/>
        <property type="gene ID" value="HMPREF0994_05643"/>
    </dbReference>
    <dbReference type="GeneID" id="29728786"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6168"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009782_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="370"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="781" mass="89615" checksum="2942BA9FC757CB46" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIJ5</accession>
    <name>F7KIJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255481.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05674"/>
    <dbReference type="EnsemblBacteria" id="EGN32163">
        <property type="protein sequence ID" value="EGN32163"/>
        <property type="gene ID" value="HMPREF0994_05674"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6198"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="460" mass="50167" checksum="485A9F2510B1B5CC" modified="2011-09-21" version="1">MQQENLMGTMPIPQLIIKTSIPLIISLLVNNLYNLVDSIFVSRVSEEALTGIALAAPLQMIMIALGCGLAVGLNAMVSKALGEKKQEEVKKTTSAAIVMAFGAYLINAAVCLLAARPYFAWQAGGNETIAEYGSVYIRICMLFSFGQMIQWVFDRLLIATGKSTLFLATLGTASIVNLILDPILIFGYFGFPALGTAGAAIATVTGQIAGGLLGIWLNIKRNKEIPIHFTIHISGKYVVNILKVGIPTAIMQGIMSVMGIFINTILYQFSSTAVAVYGILMKVQNIAQIAVHGMNNALIPIIAYNYGAKKEGRIRETIKCAFLYAFIIMSAVLVLMELIPDKILLLFDASEQMLRIGIPAVRFMSLSFYIGTIGIIFAAVFQGFGNGSYSMYLAFSRQAILLAPLLLLGAWLKQLHLVWLSFAIAEAISIPFGILLYRRIGKNGKPPETEYEETGFRYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ27</accession>
    <name>F7KJ27_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255632.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05856"/>
    <dbReference type="EnsemblBacteria" id="EGN31484">
        <property type="protein sequence ID" value="EGN31484"/>
        <property type="gene ID" value="HMPREF0994_05856"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6407"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="242" mass="27546" checksum="2A5156E4DD8F9A8D" modified="2011-09-21" version="1">MRAAVISDTHDLLRQEVTDIMESCDVIIHAGDVNTQKLAEQLEKKKPLYLVRGNNDGEWASGLPETLWFELEGVSFYMIHNKREIPEVRREADVIIYGHTHNYDCQKEGNTLWLNPGSCGKRRFSLPITMAVLELHNGSYEVERIDLPLAEESAPDRKNTNLEEIYTLERGVAVKRIMKGMDRGESIRMMAEKWRLPENFVEQVCRIRVTHPGVNAAGIVDKMEANDTIKYAAGSHIRKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ44</accession>
    <name>F7KJ44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255650.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05874"/>
    <dbReference type="EnsemblBacteria" id="EGN31502">
        <property type="protein sequence ID" value="EGN31502"/>
        <property type="gene ID" value="HMPREF0994_05874"/>
    </dbReference>
    <dbReference type="GeneID" id="29729342"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6427"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227567_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356961" evidence="3">
        <location>
            <begin position="34"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2502"/>
            <end position="2520"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="4">
        <location>
            <begin position="335"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="4">
        <location>
            <begin position="422"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="4">
        <location>
            <begin position="1346"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2433"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2438"/>
            <end position="2452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="2528" mass="273845" checksum="9FBBAB17B3DAEA37" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJQ1</accession>
    <name>F7KJQ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_32N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255867.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06091"/>
    <dbReference type="EnsemblBacteria" id="EGN31445">
        <property type="protein sequence ID" value="EGN31445"/>
        <property type="gene ID" value="HMPREF0994_06091"/>
    </dbReference>
    <dbReference type="GeneID" id="29723905"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6670"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042071_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="2">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="472" mass="55100" checksum="D5504AFFC6B96430" modified="2011-09-21" version="1">MKGNYNIFYTPEKQYPGMPHGEMCGDFMPFFWKGTYYLFYLYKYCVYAVETKDFVRFGEPYLVLQNGSPDDQDWHIGTGSVFEHDGLFTFHYTGFCEGNNGVEGKNVQVVLRATSTDLKHWEKDKEFFFRPDTRYYGNLHWRDPHVIWNEELGKFCMLITATEKEGAYLRTGCTAVYVSEDVRNWEHYKTLYAPRTFITHECHDCFRMGDKWYLTFSNYSRWWETRYRVADSFDGPWRVPAEDDMFDGREFYAAKSVTDGKKRYMVGWESIREDCRDNGRHLWGGNLLVHELVQREDGSLGVRLPETIEDSFRKELPVTLSPRQGSFAKDKEGLTGSVPDGFGWAGLGMLKETCLLQTTLSWSEGTEAVGLMIHTDDELRKWCQLRLEVRHGKILMDRYNRVDGDQYYLDERSVAFRDNKAEVKLIVSGNIMLVYVDDVALACRCYEIGIGEVGIFVEYGNVRCTQTRLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJY5</accession>
    <name>F7KJY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TrkH family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_06174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255950.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06174"/>
    <dbReference type="EnsemblBacteria" id="EGN30667">
        <property type="protein sequence ID" value="EGN30667"/>
        <property type="gene ID" value="HMPREF0994_06174"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6762"/>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026429_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN30667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="449" mass="48298" checksum="9A31244AFB3C2A6A" modified="2011-09-21" version="1">MFHYIRKKLTQAQIIALGYFLVIAAGTLILMLPIATKSGEMATPLTALFTATSATCVTGLVVVDTASYWSLFGQCIILLMIQVGGLGFMTIGVLFAMFLNKKISLKTRGILQESMNTNQVGGVVRLVRKALIGTAVIEMAGALLLMIRFVPEFGFARGIYFGIFHAVSAFCNAGFDLMGTSKGPYSSFTAYADDALINVTIMALIVVGGIGFFVWDDICHNKLHIKKYKLHTKIVLSCTAILIVGGALFIYLFEKDGLMAGMSAREAVLTSAFSSVTARTAGFNTIDTAGLTTSSKMLTVLLMFIGGSPGSTAGGIKTTTIVVLLIYVWSNLRGARGCNIFERRLEDDAVRKASDVAVISLFMAVVASIAIPYFQPHLLMEDVVFEVFSAIGTVGMSTGITRDLSAASRIIVVLLMYCGRIGSMSFALSFMERKKVAPVKLPEEKVMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK70</accession>
    <name>F7KK70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256025.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06249"/>
    <dbReference type="EnsemblBacteria" id="EGN30518">
        <property type="protein sequence ID" value="EGN30518"/>
        <property type="gene ID" value="HMPREF0994_06249"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6847"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088936_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="67"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="29231" checksum="DAE68FCE5003A071" modified="2011-09-21" version="1">MNYTEHNAKAWDVIGEGSSEDGRAQFTQMISHEDYLRAKEGLLQVSLTSSKYVPENWFPSLKGKKILGLACGGGQQGPVFAAHGADVTIIDISPRQLENEKLAAKREGYSITTLLCDMEKTLPFDDNSFDIIFNPVSNCYIENILPVWKECARILKTGGILMMGYVKEEHFMFEPDFSRDQALTTIYKLPFHSLRDLSEEKKQKMLKNHEPLLFSHSLTEQIGGLIKAGFLITDLYEDGDGGGLFDQYMNSYVAVRAVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK84</accession>
    <name>F7KK84_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30182.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06263"/>
    <dbReference type="EnsemblBacteria" id="EGN30182">
        <property type="protein sequence ID" value="EGN30182"/>
        <property type="gene ID" value="HMPREF0994_06263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320958_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356998" evidence="2">
        <location>
            <begin position="34"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30182.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="904" mass="99071" checksum="C6C655C6DF4F28F1" modified="2013-09-18" version="2" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKT3</accession>
    <name>F7KKT3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pfkA</name>
        <name evidence="16" type="ORF">HMPREF0994_06462</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 14">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256224.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06462"/>
    <dbReference type="EnsemblBacteria" id="EGN47597">
        <property type="protein sequence ID" value="EGN47597"/>
        <property type="gene ID" value="HMPREF0994_06462"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7074"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 14 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="15">
        <location>
            <begin position="8"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="14">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="14">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="14">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGN47597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="324" mass="35001" checksum="931B752B8DC6E328" modified="2011-09-21" version="1">MAKAIKTIGILTSGGDAPGMNAAIRAVVRKAITNGVNVKGIKRGYQGLLNEEIVDMQARSVSDIIQRGGTILGTARCQEFKTEAGQQKGADICRKHGIDGLVVIGGDGSYQGAQALSRHGINTIGLPGTIDLDIACTDYTIGFDTAVNTAMQAIDKVRDTSSSHERCSIIEVMGRNAGYIALWCGVANGAEDILLPEKYDYNEQNIINNIINNRKRGKTHHLIINAEGIGHSTSMARRIEAATGVETRATILGYMQRGGSPTCKDRYYASIMGCLAADILCEGKTNRVVGYRHGEFKDFDIEEALAMQKDIPEYEYKISKLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL34</accession>
    <name>F7KL34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47283.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06564"/>
    <dbReference type="EnsemblBacteria" id="EGN47283">
        <property type="protein sequence ID" value="EGN47283"/>
        <property type="gene ID" value="HMPREF0994_06564"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47283.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="31732" checksum="A7D26D2E0ABBBC46" modified="2013-09-18" version="2">MKKKKMYSTWFLLPAMIVFLIIFIIPTVTSFFFSMTVWDFKTYRFIGFDNFKMFLTERSLNIGIKNTLIYAFLTCGIKVLLAFFIAVFLTGSIRTKNIQRSIIFFPNLVSTMAIGITFTAMMHPSKGLINKALGLFGAANINWLGNPDLALYSIIGVDVWKGLSIATVIYVAGIQSIDKTYYEAAEIDGANARQKLFSITAPLARPAMNSVIILSFIGGLRSFDLIWAMTGGGPGFATDVMSSIVYKQYAAGFYGLSTAGNVIMFIMIALLAFPLQKFLLSREVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL74</accession>
    <name>F7KL74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002570687.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06607"/>
    <dbReference type="EnsemblBacteria" id="EGN47326">
        <property type="protein sequence ID" value="EGN47326"/>
        <property type="gene ID" value="HMPREF0994_06607"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7230"/>
    <dbReference type="eggNOG" id="ENOG502Z860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129326_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN47326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="166" mass="18921" checksum="B4FB0CFAB096A8FE" modified="2011-09-21" version="1">MQEEVENRTLTLVVSGTKFTGRLLKAAISKYMAHCKEKKLQKQRSRDAPVTPHGKQTVKQLIGQNQGISNIEITDPSIKEFEKIARKYGVDYAVKKDRSSSPPKYLIFFKGRDADALTAAFTEYTSKKVKKAEKTERPSVLAKLSQFKEMVKNAVVDRTKRKELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLJ8</accession>
    <name>F7KLJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256489.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06736"/>
    <dbReference type="EnsemblBacteria" id="EGN46660">
        <property type="protein sequence ID" value="EGN46660"/>
        <property type="gene ID" value="HMPREF0994_06736"/>
    </dbReference>
    <dbReference type="GeneID" id="29724781"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_623818_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="425" mass="46955" checksum="4AD72BA2ED2A1AE5" modified="2011-09-21" version="1">MINVNDFLGCTDNEVLEAAMENREKDGIIIIPPRSSEVEPERDYWLLERAILVPENTVVILQNCTIKLSDRCRDNFFRSANCGPGIAEPKQIHNIYIKGEGTCTLLGADHPRATGDAGKILAQPCPYDPEDLCRLADWIPVERRKPESLDFWDSHNHSYGTDAGKEGEHQRGDWRDIGILMANVDHFGIENLRIVDSHGWGITMEACSCGSIRNINFDACMSRMIDGLCQNIENQDGIDVRNGCHNLIISDITGRTGDDMIALTAIADNGYAGSTEGGRLGAGEVMPVDWSKRDRDIHDIIIRNVIGYSHLCWQVRLLPCNCKIWNVVIDGVIDTAPDGLVHGGGVIIGEADLAYGMNLPDGLKNISISNVLANGAHALLIEGYLKDSMISNVMNRNTEGLTWEVRRENGMDNWNVKMSNISGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLP1</accession>
    <name>F7KLP1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06770"/>
    <dbReference type="EnsemblBacteria" id="EGN46362">
        <property type="protein sequence ID" value="EGN46362"/>
        <property type="gene ID" value="HMPREF0994_06770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7396"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="PTHR22936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="55"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="209" mass="23336" checksum="CC4D38DC10BBCBB4" modified="2011-09-21" version="1">MVKPQTYRYQNQNMKEIPWCSAVLTAANVIIFLVCQFTGDWLYIKGEFGAFYLIRSQEYYRLVTAMFLHADISHLVNNMILLYFGGEIVEKTIGSVRYLVLFFVSGICGNLLTAIFEVSTGMYFNSIGASGAVFGLIGGLLYLVITRKGYAAQISVRRMILMIALSLYSGFQSVRVNNAAHLGGLLSGFLITFILCHIGKNVGENHYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLR0</accession>
    <name>F7KLR0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256542.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06789"/>
    <dbReference type="EnsemblBacteria" id="EGN46381">
        <property type="protein sequence ID" value="EGN46381"/>
        <property type="gene ID" value="HMPREF0994_06789"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7419"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="32913" checksum="0A5F69F27355D48D" modified="2011-09-21" version="1">MRRKTLGMKIFTVFNYAFLTLLAISCLLPMLNQLAISFSSSSAVAAGEVGLLPVDFTLDSYKYMADKPEFWKSLSVSLGRILLAVPISMIVCVLAAFPLSRLDHEFPARKYYIWVFVVPMLIGGGLIPTYMVVRNTGLIDSIWSLVLPNAVNVFNTILLMNFFRSLPKELEEAAYVDGATNFRVLRMIILPVSKPVLATVTLFVIVNHWNSWFDGLIYLNSPMKYPLQTYLQTQVVSTNLMALETLRDVRQIGLISDRTGKAAQIFLAAVPVLMIYPFLQKYFTTGIVMGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRJ5</accession>
    <name>S2KRJ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mprF</name>
        <name evidence="7" type="ORF">HMPREF0994_07285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LPG synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EPC05064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360277.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07285"/>
    <dbReference type="EnsemblBacteria" id="EPC05064">
        <property type="protein sequence ID" value="EPC05064"/>
        <property type="gene ID" value="HMPREF0994_07285"/>
    </dbReference>
    <dbReference type="GeneID" id="29729703"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039146_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="353" mass="39201" checksum="2271DF866F5A7777" modified="2013-09-18" version="1">MKIRKNWGKWLFVLALIFLVCVANRKVLPEILREAARTSPILIGMSCLLSAGYFLTEGKIIQVMTGLNEPRLNEPLRHQSAFTWGKGITCAFYCEFYRVATLGSGSGIAEIYYLNSYGVQAGTATGMSLVQYIMYKLAVAAYGIAGFLIPTAKGESCVRGYGKLMLLGCLITVLVTAALLFVAIGKRACSVIFTFLKKKGKGRWEEKLLTLEEQAELCQKEAGLLLKNPKKLLCIILLNILKVSFWYAVPWLFLAGKIPLSLPEIMLLTALIQMLAAVIPVPSGIGSVEYVFTLFFGVYAGSVSAVSAALMYRFATFLFPCIPGGVLAFRHYRWNKKRKITQAEERKEYLSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRQ8</accession>
    <name>S2KRQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360267.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07278"/>
    <dbReference type="EnsemblBacteria" id="EPC05129">
        <property type="protein sequence ID" value="EPC05129"/>
        <property type="gene ID" value="HMPREF0994_07278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="452" mass="48555" checksum="11558ED4484533FA" modified="2013-09-18" version="1">MEKRKSQKWSMLEGTPGIALFLFALPLILGNLFQQFYNMVDSMIVGQFVGENALAAVGASYALTNVFVMIAIGGGMGASVITSQYLGAGDTEKMKTSVYTALLTFLAVGSLLGIFGFLMNRQILLWLHTPDNIIAAAGTYLGIYFLGMPFLFMYNILSSMFNSLGDSRTPLFLLIFSSVLNVFLDLWFVLQFGMGVAGVAIATVIAQGTAAVISFLLLMHRLNGFETEEAVPKYDVGILKSMVKIALPSILQQSIVSIGLLLVQSVVNGFGSSVLAGYAASTRIESICIVPMISTGNAMSTFTAQNMGAGRPERVRRGYRAAYAITGGFALLIGLILFFFDKQIIGAFMNSQSGGTAFATGTGYLSFMKFFFIFIGLKAITDGVLRGAGDVMVFTLANLANLAVRVLGAFLFAPVVGVAAVWYAVPAGWAINYMISLCRYLTGKWSKKSLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSE3</accession>
    <name>S2KSE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07154"/>
    <dbReference type="EnsemblBacteria" id="EPC05207">
        <property type="protein sequence ID" value="EPC05207"/>
        <property type="gene ID" value="HMPREF0994_07154"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50328S6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3100056_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="51" mass="5710" checksum="5D177B57AD4B1D83" modified="2013-09-18" version="1">MSIVAVLYTILIYLLIAAVIGGFLFFIIKKAVKEGVLDALEEWHGESDRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVL4</accession>
    <name>S2KVL4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RepA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EPC05030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002594233.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07316"/>
    <dbReference type="EnsemblBacteria" id="EPC05030">
        <property type="protein sequence ID" value="EPC05030"/>
        <property type="gene ID" value="HMPREF0994_07316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055973_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010724">
        <property type="entry name" value="RepA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06970">
        <property type="entry name" value="RepA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepA_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="246" mass="27494" checksum="EDB40B704902EC5C" modified="2013-09-18" version="1">MTAGTELPAYLPYPRFLLETDLSHTARELYALLLDRSTLSQKNGWQDSEGRTYIVYPIAEIAEMLDKGCTTIKGALNELDAAGLLERRRTGFSAANRLYVKVPPIPVVQFSDQLTDGKPPLIRAGNRPTDSRKTDLMTVGKPSPNQTNINNLIESQTKGASEGQPPAAYGRYKNVFLSDTELLELEQDFPGKWEYYLDRLSCHIASTGKQYQSHAATIYKWAQEDAAKEKPKKGIPDYSFKEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAN5</accession>
    <name>S2LAN5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpD</name>
        <name evidence="6" type="ORF">HMPREF0994_07105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359965.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07105"/>
    <dbReference type="EnsemblBacteria" id="EPC05256">
        <property type="protein sequence ID" value="EPC05256"/>
        <property type="gene ID" value="HMPREF0994_07105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="24374" checksum="56DA6F3970786F70" modified="2013-09-18" version="1">MAESNIFPTKGNLIMVKNSLELAKQGYELMDKKRNILIRELMNLNEEAKAIQSEINDTFTNAYEALQQANIEVGIHYVQEISHAVPIESSIRIKTRSIMGTEIPKVEYTPDEAGPSYGFYSTRESVDRAREGFLKVKELTIKLSMVENAAYRLAMNIRKTQKRANALKNITIPTYTALVKDISNALEEKEREEFTRLKVIKRNMNKKKEQEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJP4</accession>
    <name>S2LJP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_07169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360080.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07169"/>
    <dbReference type="EnsemblBacteria" id="EPC05173">
        <property type="protein sequence ID" value="EPC05173"/>
        <property type="gene ID" value="HMPREF0994_07169"/>
    </dbReference>
    <dbReference type="GeneID" id="29727294"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EPC05173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="544" mass="60170" checksum="02994817644A5933" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJX0</accession>
    <name>S2LJX0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent helicase/nuclease subunit A</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase/nuclease AddA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">addA</name>
        <name evidence="13" type="ORF">HMPREF0994_07087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -&gt; 5' nuclease activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of AddA and AddB/RexB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. AddA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359929.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07087"/>
    <dbReference type="EnsemblBacteria" id="EPC05238">
        <property type="protein sequence ID" value="EPC05238"/>
        <property type="gene ID" value="HMPREF0994_07087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001114_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01451">
        <property type="entry name" value="AddA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014152">
        <property type="entry name" value="DNA_helicase_suAddA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF48">
        <property type="entry name" value="PTHR11070:SF48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02785">
        <property type="entry name" value="addA_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="3"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="485"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="940"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EPC05238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1210" mass="137896" checksum="4A9E0A265D362B84" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2D3</accession>
    <name>F7K2D3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZnF_CHCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249961.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00012"/>
    <dbReference type="EnsemblBacteria" id="EGN48245">
        <property type="protein sequence ID" value="EGN48245"/>
        <property type="gene ID" value="HMPREF0994_00012"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.14"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094413_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="5">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN48245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="215" mass="25111" checksum="52FFBAB5A4086963" modified="2011-09-21" version="1">MNVFEAVKQSVTTRQAAEHYGVRVGRTGMCVCPFHDDKNPSMKVDRRFHCFGCQADGDVIDFVSRLENVSPKEAALMLAQDFSIPYEDKEPPGRSRPKRKPRQESPEQQFKSMERYCFRVLSDYHNLLRRWKRDYAHKTPNEEWHPFFVEALQKQSHVEYLLDVLLFSDMRKRAALIASYGKEVRNLERRMADLAARTAAGRDGHHRSRTPAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2H5</accession>
    <name>F7K2H5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250003.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00054"/>
    <dbReference type="EnsemblBacteria" id="EGN48287">
        <property type="protein sequence ID" value="EGN48287"/>
        <property type="gene ID" value="HMPREF0994_00054"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.58"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN48287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="542" mass="62718" checksum="B03EF1F53966931E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2L8</accession>
    <name>F7K2L8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0994_00097</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250046.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00097"/>
    <dbReference type="EnsemblBacteria" id="EGN42714">
        <property type="protein sequence ID" value="EGN42714"/>
        <property type="gene ID" value="HMPREF0994_00097"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.102"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="208"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN42714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="447" mass="50644" checksum="D84C7CB369C3C1C8" modified="2011-09-21" version="1">MDSSSVLQFIFLVILIALSAFFSSAETALTTVNRVRVRTLIEEGNKRAIILQKILDNYSKMLSSILIGNNVVNLSASALTTTMAIKIWGNYAVSIATGVLTLVLLLCGEIVPKNAATLNSEKVSLAYARVIYTLMKLLTPLIFIVDRLSMGIMILLHVDPNKKKDQITESDLKTYVDVSHEDGIIESEEREMIYNVFDFSDAVAKDIMIPRIDMSTISVEAGYEELLGVFKKYMYTRIPVYQDDNDNIIGLVNIKDFILVEERENFRITDILRDAYYTYEYKKTADLMIEMREKRFNVAFVLNEYGSCAGMITLEDLLEEIVGEIRDEYDADEDELIQEIGERQYLVEGGMKLDDINDALDTELESEDYDSIGGIIIEILDRMPVPGDEVTTQDGITLRVEDVQQNRITKVLMTLPEPVDSDEESEEDTDTRESFFDKGNREKSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2R9</accession>
    <name>F7K2R9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250097.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00148"/>
    <dbReference type="EnsemblBacteria" id="EGN42765">
        <property type="protein sequence ID" value="EGN42765"/>
        <property type="gene ID" value="HMPREF0994_00148"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.157"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="320"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="545" mass="61228" checksum="6597BE836CE2B22F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3K4</accession>
    <name>F7K3K4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250382.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00433"/>
    <dbReference type="EnsemblBacteria" id="EGN31948">
        <property type="protein sequence ID" value="EGN31948"/>
        <property type="gene ID" value="HMPREF0994_00433"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.474"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="27664" checksum="597FEB35911E2B30" modified="2011-09-21" version="1">MHIIITGGNQGIGFYLTEHLLELGNHVTVLDVEITELLKLKEKYPAQLLPVICDIRNKDGIQEAVRMSVTNYGDIDIAIHNACLCTFGPMKDTECSVYEEVFHVNYFGALRLAKAVVPYMEKAGKGKVIFTSSGVGIMGFPDISPYASSKGAIESLAKCLNLEYMEKGIRFQLIHPPLTRTRSAAPLPVPRDFMADPKAVGYGLAGRINKESFYICHSVGQQLQTALCYLFPVKMGRSMSALLKRKQNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K431</accession>
    <name>F7K431_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44810.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359855.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00622"/>
    <dbReference type="EnsemblBacteria" id="EGN44810">
        <property type="protein sequence ID" value="EGN44810"/>
        <property type="gene ID" value="HMPREF0994_00622"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147249_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44810.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="104" mass="11683" checksum="74307304EB0B8878" modified="2013-09-18" version="2">MDNFFIVPMNPVSFQNDLDLSKNEKILGSSGTDMFRDIFQSMISDAAAADTEYEKQKYLLATGQIEDAHSVTIAGSYAQLTVDMLVSLRNKAMESYNELMRMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K435</accession>
    <name>F7K435_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250575.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00626"/>
    <dbReference type="EnsemblBacteria" id="EGN44814">
        <property type="protein sequence ID" value="EGN44814"/>
        <property type="gene ID" value="HMPREF0994_00626"/>
    </dbReference>
    <dbReference type="GeneID" id="29725986"/>
    <dbReference type="eggNOG" id="ENOG5033RBA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893668_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="35451" checksum="2D600AD40309F6D1" modified="2011-09-21" version="1">MFKNVKKKTVIIMMVIILPVAAAALVCTLLVVKKDEKEKPVLPPEYYFAKEDELSSVTDIVGERGFEDLSPRDEESGSQDGTEETEVQESTEEGNAETTAAEASVDADKEGLSVEKYRYIAGENTPTDVKEYIAYLTEKKNFIDLTQEEGEDEEEPEEEKKTYTYKLAGPSHDSDAYLEITIEAEDDSFTVTALKKGEAWNSYVTQLWDEEKKKNRQKTPEEPKSTMQIAEEKVRSMSQEALKLQEPVDTYSFVCTPGLIKLEDKDFYRVSAYKKKENGTMIYECAYLVECASRKVSYKYNYVTEETELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4M8</accession>
    <name>F7K4M8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peripla_BP_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00814"/>
    <dbReference type="EnsemblBacteria" id="EGN43523">
        <property type="protein sequence ID" value="EGN43523"/>
        <property type="gene ID" value="HMPREF0994_00814"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.888"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="51"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="338" mass="37525" checksum="28B2A5539F3812D2" modified="2011-09-21" version="1">MKNNTGHVLKNMIMSNKKRILSAALLLIAAAFLLSYAFGREDREKKQLSIIFISKTIDDSDFWTQLIDGARMAAEEYEVKFSVCAPETEDDYVRQNELIEQAILEKPDAIVLTPSSFTETTPMAEKIVENGIRLFLLDSEIDTKVAECMISTDNIKAGRLQGEFVKKILRPDSRIAVVAHVKNSSTAMEREQGLREGLGSDAEKIADVVFCDSNYDKAYQLMLQILAEHPDVDVVVGLNEYSAVGAARAIVDKGLAGKISFVGFDSSLEEIKMLEGGIFRGMVIQNPFKMGYLGVETAVKALNGEKVPDQIDSGSVLITRENMYLDENQEMLFPFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7K531</accession>
    <name>F7K531_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_00969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250918.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00969"/>
    <dbReference type="EnsemblBacteria" id="EGN43278">
        <property type="protein sequence ID" value="EGN43278"/>
        <property type="gene ID" value="HMPREF0994_00969"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1059"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363718" description="Histidine kinase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="185"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="252"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN43278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="459" mass="51746" checksum="A2925C02DA90E278" modified="2011-09-21" version="1">MKLWKKLSLVTTVTLFLATGVSGAAVIGQTLRYNVEKTTESYRQQLQATAYALGRDIGESELLGYSEATRSSFFNFLMKKYGASRYILTKEGEVLCNLTDFELVNPQDERWAQTEPAVDTREVEGKRLLIMGKKIPMDSPADYRLVLVADISQVYRDMEKQVMLFLEFYLAAAVISVLFIFLLTRRMLSPLRELQKAAFDISEGVLNRRARVKSHDEIGEMAGSFNRMADRIEEQVTQLEQVSRQQKQLLGSLTHELKTPMTSIIGYSDTLLHVKVDEERQNKALLHIHEECRRLERLSGKLMSLIGLYDNDSIRMEEVDIEELFAGVAQLEKYQLEEKGMRLETRAAGQKRMLDRDLFESLLINLIDNAVKAGKEGDSILLEATEGGISVTDHGKGIPEEEISRVTEAFYMVDKSRSKKAGGIGLGLALCSQIAALHHGRLHIESKVGQGTRVSILFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K568</accession>
    <name>F7K568_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_01006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250955.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01006"/>
    <dbReference type="EnsemblBacteria" id="EGN43315">
        <property type="protein sequence ID" value="EGN43315"/>
        <property type="gene ID" value="HMPREF0994_01006"/>
    </dbReference>
    <dbReference type="GeneID" id="29726228"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1097"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="9">
        <location>
            <begin position="196"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase_ig" evidence="12">
        <location>
            <begin position="662"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_mannosidase" evidence="11">
        <location>
            <begin position="757"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN43315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="845" mass="97536" checksum="9DB439B35D1F0301" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K581</accession>
    <name>F7K581_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250874.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00925"/>
    <dbReference type="EnsemblBacteria" id="EGN43234">
        <property type="protein sequence ID" value="EGN43234"/>
        <property type="gene ID" value="HMPREF0994_00925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1012"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="39740" checksum="B959FE0B9844B7C2" modified="2011-09-21" version="1">MKLLTITIPCYNSEKYMHKCIESLLPGGEDVEILIVDDGSTDGTAAIADEYALKYPSIIRVIHKENGGHGSAVNTGIENATGLYFKVVDSDDWVSDTAYREILDKLTELTGGEEVLDMLIANYVYEKEGEKRKKVIRYHHVLPEEELFTWNDVHRFHKGQYILMHSVIFRTKLLKDCGLKLPEHTFYVDNIFVFEPLPYVKKMYYMDVNFYRYYIGRADQSVNEQVMIGRIDQQIKVNKIMVDYVVSKKQFLATHKKLRNYMLNYLDIITTVSSIMLIYSGVDENLEKKNELWKYIKQKDPVVFFRLRYGLLGSYTNLPGKGGRKISVEGYKLCQRFFKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5A2</accession>
    <name>F7K5A2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01031"/>
    <dbReference type="EnsemblBacteria" id="EGN43004">
        <property type="protein sequence ID" value="EGN43004"/>
        <property type="gene ID" value="HMPREF0994_01031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="33342" checksum="830D1B63FD6474A9" modified="2011-09-21" version="1">MKETKGQKIFKVFNYTILCLLGLATFYPFWYVLVASFNTGRDFLKGGVWLYPRQFTLENYIMAFKDERIYQSLSISVSATLLSVVVGLLFTALIAYALSIRTLPGRTFLNFFWYFTTIFSGGMIPFYMVLRSMGLTSSFWLYVIPSIYSFYNFVLLRTNFANIPYELRESAQLDGAKETTILMRIYIPLSKPILATLALFIGVGKWNDWFTGAYYQSKAALYPAATVLQKILSEATASSQVKVGQETALGSMTSYTSQSLQMAFVMILTMPIVIIYPFLQKYYVKGVMVGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5A4</accession>
    <name>F7K5A4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250982.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01033"/>
    <dbReference type="EnsemblBacteria" id="EGN43006">
        <property type="protein sequence ID" value="EGN43006"/>
        <property type="gene ID" value="HMPREF0994_01033"/>
    </dbReference>
    <dbReference type="GeneID" id="29725270"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_15_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="377" mass="42863" checksum="8626954F7C1073B9" modified="2011-09-21" version="1">MPTFPDQPLYQKIKEDILRQIKDGQLLPGDKIPTEYQLMEKYGVSRITVSKALSELKSEGIITRFPHKGTFVTKSVLLPPLVRDTPIPSSHTAMPASMTEIACILPSITDSFSLSMVNGVQSVFPEDTYICHIFQSHNPTVENYLLQRCLELNISGIVLFPQDQPFFSNQLLAMQLQNYPLVLLDRYLPRLNTNYVIADNKAAGELCLRHLHKLGHQRIAFVTSTDRNTFSVKYRIEGIQETALSLNLPDYAVQLVEFLDKHKKFSYYQDLFLNLITQNRVTAFITAESSTCTYLYDLLTSLDIKVPGDVSLMSFDKPVCSSRNPDFFTHISQSEYLMGREAGTLLKNRIELYDINTYHRVITPTLHVHESTGSVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5C4</accession>
    <name>F7K5C4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251002.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01053"/>
    <dbReference type="EnsemblBacteria" id="EGN43026">
        <property type="protein sequence ID" value="EGN43026"/>
        <property type="gene ID" value="HMPREF0994_01053"/>
    </dbReference>
    <dbReference type="GeneID" id="29724286"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1153"/>
    <dbReference type="eggNOG" id="ENOG502Z9TS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102870_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="235" mass="25498" checksum="0B0297B830744366" modified="2011-09-21" version="1">MNKLISLELKRNSLRSYHTAALISALCLLALLYLFAAIPKLDGTETGLDMFMTYRSLIGITNIIGMVIFAVLSAVMSARFIVEEYAGKRAVLLFSYPVARRSIISSKIEMVFFYTAAAMFLCGAIVYGIFFATESILPLCAEPLSAETIVYSLFSLICYSLLAGIMGIIALWFGFGRHSVTVTIVAAVIIAVISCQIMAMTMTSLAASLLFLAAGGIIAVIVIKNLIDQVEKMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5P5</accession>
    <name>F7K5P5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01174</name>
        <name evidence="3" type="ORF">HMPREF0994_07045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42575.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01174"/>
    <dbReference type="EnsemblBacteria" id="EGN42575">
        <property type="protein sequence ID" value="EGN42575"/>
        <property type="gene ID" value="HMPREF0994_01174"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05377">
        <property type="protein sequence ID" value="EPC05377"/>
        <property type="gene ID" value="HMPREF0994_07045"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="137"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42575.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="36928" checksum="025EEDCD957CA3ED" modified="2013-09-18" version="2">MNESDCKFEIIYGLVSKEDNLLSVTMLCDIAGVSRSGYYRWAGAADERQRKELKDQADFEIILGAYAKRGYDKGAKSIYMTLIHQNPPIIMNVKKIRRLMKKYGLVCKIRAANPYRRMAKAIKTNHVADNLVKRQFTAYGARRVLLTDITYIPYNGVFCYLSTILDAFTKQILSYVLSESLEVDFVLQTVNRMVEKHGVSLSAEAIIHSDQGCHYTSCSFIQLVKDRGLRQSMSRRGNCWDNAPQESFFGHMKDEVDISRCAVFQEVKTIIDDWLDYYNNERYQWQLAKLSPNEYYQYITTGNYPLRGIINEPEKEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5U8</accession>
    <name>F7K5U8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251176.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01227"/>
    <dbReference type="EnsemblBacteria" id="EGN42474">
        <property type="protein sequence ID" value="EGN42474"/>
        <property type="gene ID" value="HMPREF0994_01227"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1340"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026719_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="527" mass="60455" checksum="4FA3D38345EA98B0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K627</accession>
    <name>F7K627_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_01306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251255.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01306"/>
    <dbReference type="EnsemblBacteria" id="EGN42168">
        <property type="protein sequence ID" value="EGN42168"/>
        <property type="gene ID" value="HMPREF0994_01306"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1427"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="508" mass="58610" checksum="20F5C1B121B1ECF6" modified="2011-09-21" version="1">MLFNSYIFLFLFLPLCLGGYYLLAHFGKAKPAKLCLTGFSLWFYGYFNPSYLLIMLFSILFNYCIFRLIISARKKNRMSGIAGSRFWMTIGVLSNLGILFYFKYYDFFIENVNAVFDTSFMLKGILLPLGISFFTFQQIGFVVDSYRGEIESCSFLDYSLFVSFFPQLIAGPIVNHNEMMPQFEQIGHRQMDWSQFTSGVYLFTLGMVKKVLVADTFGKAVNWGYSNVSGLTGVDSALLILFYVLQLYFDFSGYCNMARGLGWLFGIEIPVNFNSPYKAVDIVDFWKRWHITLSRFFTKYVYIPLGGNRKGRGRMYGNLFMIYLLSGIWHGAGWTYVLWSVTQGVLYILTRMWQLYKKERKVPAAEKEKSPFLQKLVRVGGILFTFVYFSLTCVFFRSETVAQALEIFRRLFTGGIAVPAEAMTQGFNLDEFWYVMKLLHLDRLPYSQMYLCGGITLITLIVVFAAPNADELAERFKPKVWNALVMAGLFLWCILSLSGVSSFLYFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K659</accession>
    <name>F7K659_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FdtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251288.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01339"/>
    <dbReference type="EnsemblBacteria" id="EGN42201">
        <property type="protein sequence ID" value="EGN42201"/>
        <property type="gene ID" value="HMPREF0994_01339"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1460"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127501_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20292">
        <property type="entry name" value="cupin_QdtA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="138" mass="16142" checksum="E7985C7A5CCFBA5F" modified="2011-09-21" version="1">MEVQIINFQSHGDERGELIALEENKNIPFEVKRVYFMYNTKEEVHRGFHAHKKLRQVLFCPCGSCTIKLDSGRETVTVRLSNPTEGLVVEANTWREMYDFTPEAVLMVLASDYYDESDYIRDYDEFLQYVGACERKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K663</accession>
    <name>F7K663_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01343"/>
    <dbReference type="EnsemblBacteria" id="EGN42205">
        <property type="protein sequence ID" value="EGN42205"/>
        <property type="gene ID" value="HMPREF0994_01343"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1465"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1775032_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="146" mass="16969" checksum="B3A73343E9EBAA6E" modified="2011-09-21" version="1">MGIQSCMDNSKSNVKLSVCLLTFNHEKYIRQCMDSFFKQEVDFDMEILVGDDCSTDKTVEILESEYGESINLYKRESNVGLCANMYDLFMKARGEYVFLFSGDDYLYGDDVWKRQVDFLENNNDYFSVSARKLHYNQVKQIFIGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K696</accession>
    <name>F7K696_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01384"/>
    <dbReference type="EnsemblBacteria" id="EGN42246">
        <property type="protein sequence ID" value="EGN42246"/>
        <property type="gene ID" value="HMPREF0994_01384"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1504"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039510_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="53"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="392" mass="44365" checksum="4D1407BE65EB5CED" modified="2011-09-21" version="1">MNPLKKDKIVLYMHAGSGNHGCEAIANTVCRMLPKPAIVVTNSAEEDEAYSLKGLCTLVEEKKIRKNFFIHVYYYLKERLFHDPEAAMRYRFREVTGKNLRNLNISIGGDNYCYDLLLKDLKLANKMFREQGGKTVLLGCSIEPELLTDPDIIDDMKRYTCIIARESITWEALQDAGVKDSTYLIPDPAFLLNTVEKPVPEAFKEGNMVGLNLSPMAVENESVAGITMENYRALISHILDTTDMNIALIPHVVWKNNDDRTVLQSLYRDFSKTGRIVLIEDCSCEELKGYIARCRFFIGARTHSTIAAYSSLVPTLAVGYSVKARGIAKDLFGTWEDYVLPVQSLSRKGELIEGFEWLKEQEQAVRARLEKVMPAYLERTRQIGKTLGKLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6L2</accession>
    <name>F7K6L2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HPr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251471.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01522"/>
    <dbReference type="EnsemblBacteria" id="EGN41996">
        <property type="protein sequence ID" value="EGN41996"/>
        <property type="gene ID" value="HMPREF0994_01522"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1660"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="76" mass="8643" checksum="D8D11546EC1E4CC8" modified="2011-09-21" version="1">MKTVKISLNSIDKVKSFVNDITKFDYDFDLVSGRYVIDAKSIMGIFSLDLSKPIDLNIHAEDNSDEVLEVLKPYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6N4</accession>
    <name>F7K6N4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">HMPREF0994_01544</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01544"/>
    <dbReference type="EnsemblBacteria" id="EGN42018">
        <property type="protein sequence ID" value="EGN42018"/>
        <property type="gene ID" value="HMPREF0994_01544"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1684"/>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_1_2_9"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGN42018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="29388" checksum="B7621D442BB99B24" modified="2011-09-21" version="1">MKQIWNSFRLAFSMYSIIPARQIDKTKENTKYILCFVPWVGAVIAFLITEWRIVHPYLLDYEFLRSVVCVMIPLLLSSGAFMDGFFRTVDALSSHQPRKGKLEILQDSHSGYFAIITCVSYFLIIVGLWSEMPIDGWPVVALGFILSRTLYGLSIIFLRHSQTSKCSLYVPEGKAKTAVAAILILYTAACAFFMLRMNLTVGLACLAGAVIAFLYYCWVAYKHFGGITEDIASFFVQVCEILIPLMALLVYRMPTDFTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6S6</accession>
    <name>F7K6S6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MobC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01593"/>
    <dbReference type="EnsemblBacteria" id="EGN42067">
        <property type="protein sequence ID" value="EGN42067"/>
        <property type="gene ID" value="HMPREF0994_01593"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1742"/>
    <dbReference type="eggNOG" id="ENOG502ZTUJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137404_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="109" mass="12379" checksum="4FAEB8F25D56A829" modified="2011-09-21" version="1">MANRKRKFVLRVPVTPEERALIQQKMAQLGTKNFSAYARKMLIDGYIVHIDTGPVRAQTAELQKIGVNINQIARRINSTGTVYAQDLEDIKGALTQIWQLQRSILSSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K784</accession>
    <name>F7K784_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01713"/>
    <dbReference type="EnsemblBacteria" id="EGN41695">
        <property type="protein sequence ID" value="EGN41695"/>
        <property type="gene ID" value="HMPREF0994_01713"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1872"/>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629633_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="6">
        <location>
            <begin position="95"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="383" mass="43874" checksum="E320FF2E19BB47DF" modified="2011-09-21" version="1">MKPLEDYSDIRGFCYSGGYRVPEEQLKRELGYAGSLRLNSTRIWLSEREYRKAPGDFLKKLCSFVETAWEAGISTMPILFNGNGLDPGDLEQGYEEYADRYVKDVVQALRGEPGLIMWDVMNEPSCNDYILEAEGEERKARWEKVNEFLRRSCDKVRRLDNVNAVTIGHTYMSDVEDTIGEVDVFSFHDYLPVRRQIEESYLAAEELSVRTGKPFLNSELCCLCRANPYDLALDICREHHTGWYLFELMITGYWSDVHGIFYPDGTVRDPSIPAAVLGFRRKRDEGMVFPNANKEGYAQRGVAMVQEALSEKTKVFRAGRKSLDEVLEAAEFCANLLEACELVPMYDPPTARIARIRKAGDEREARKLAYELALLLQEKCQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7I9</accession>
    <name>F7K7I9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251731.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01818"/>
    <dbReference type="EnsemblBacteria" id="EGN41631">
        <property type="protein sequence ID" value="EGN41631"/>
        <property type="gene ID" value="HMPREF0994_01818"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1988"/>
    <dbReference type="eggNOG" id="ENOG502Z7S1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076578_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007530">
        <property type="entry name" value="Aminoglycoside_adenylylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04439">
        <property type="entry name" value="Adenyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="34385" checksum="E030DAA48E7D5F9C" modified="2011-09-21" version="1">MRSEKEMMDIIMNKALSDERIRAVTMEGSRANPNAVHDSYSDFDISYYVTDIREFTKDKSWINELGDILIAQFPTDWYSHPYDYGSRAPFAFLIQFADGSRIDLTLVDVTNISQEAENKEPRIVLLNKDNFPYLLPLQAEDVFFLRPPEEKEFLDTCNEFRWLSLYISKGVCREELYYAKNAYDVLIMPMFLKMLNWRIGTEHGFRVTTGSSCKYLKRFLSTEEMERFQGIFPDGSYENICRCLFLMYDYFHESAGRVAGHFHFYYDRMEIQRVRQFLEDRFHEKGFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7T9</accession>
    <name>F7K7T9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251897.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01984"/>
    <dbReference type="EnsemblBacteria" id="EGN41389">
        <property type="protein sequence ID" value="EGN41389"/>
        <property type="gene ID" value="HMPREF0994_01984"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2181"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_8_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="17"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="211"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="392" mass="44363" checksum="D8E0DD0C4C4DB1BE" modified="2011-09-21" version="1">MAEEKRNLETIPAGSLGIISLAGCKTLGEQVDHYLVKWRQERESEHKNSLAFSGYQRDSYILQSKVPRFGTGEGKGVILESVRGMDLYLLVDVVNYSLTYSLCGHENHMSPDDHFQDLKRIISAVGGKARRINVIMPFLYESRQHKRSSRESLDCAIALQELVKMGVDNIITFDAHDPRVQNAIPLHGFETVQPAYQFIKNLLRNQKDLQIDSDHMMVISPDEGGMGRAIYIANVLGLDMGMFYKRRDYTKIVNGRNPIVAHEFLGSDVEGKDMIVIDDMISSGESVLEVAAALKKRKARKIFICATFGLFTNGLEGFDKAFADGIIDRVLTTNLIYQTPELLERDWYINCNMSKYVAYLIDTLNHDTSISDLLDPNEKIQKLLGRYRSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K804</accession>
    <name>F7K804_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02051"/>
    <dbReference type="EnsemblBacteria" id="EGN41456">
        <property type="protein sequence ID" value="EGN41456"/>
        <property type="gene ID" value="HMPREF0994_02051"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2251"/>
    <dbReference type="eggNOG" id="ENOG502Z89I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021846_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043780">
        <property type="entry name" value="DUF5722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18989">
        <property type="entry name" value="DUF5722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5722" evidence="3">
        <location>
            <begin position="208"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="605" mass="68023" checksum="C30F5045017BA55B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8G9</accession>
    <name>F7K8G9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252062.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02149"/>
    <dbReference type="EnsemblBacteria" id="EGN41056">
        <property type="protein sequence ID" value="EGN41056"/>
        <property type="gene ID" value="HMPREF0994_02149"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2352"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="481" mass="54630" checksum="2D76E5407221F7ED" modified="2011-09-21" version="1">MSKRPNLILIMTDEMRGDCLGIAGHPDVKTPHLDTLAAQGIFYPNAYTACPSCVPARAALHTGLSQKKHGRVGYQDGIDWNYPVTMAGELSKAGYYTQCVGKMHVHPLRSMMGFHHIELHDGNLDFYRRPGTDYYEDQRIADDYYHWLHCMRGPDCDVSDTGLNCNSWVARPWPYEESLHPTNWVVSRGIDFLRRRDRRMPFFLMLSFVRPHAPYDAPQWYFDLYRNRPLRPPVKGDWDPQDPGIEGRTYNSHFTPSDPELELQQQAGYYACITHIDHQIGRFLDALHAQCAGEDNVILFTSDHGELLGDHNLVRKSYPYQSSIHIPMLIHGPERLLGSRQTVSSSLVELRDVMPTLLNLAGADIPASLDGRSMLPGGGCETRDYLHGEHSFGGESNHFIVTGNDKYIWYSQTGREQYFDLKADPGEVKNRIQAPACAERIAALRSILIRELEGREEGYSDGRRLITGQLPRAVLSEVLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8S5</accession>
    <name>F7K8S5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_38N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252175.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02274"/>
    <dbReference type="EnsemblBacteria" id="EGN41181">
        <property type="protein sequence ID" value="EGN41181"/>
        <property type="gene ID" value="HMPREF0994_02274"/>
    </dbReference>
    <dbReference type="GeneID" id="29726649"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008841_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_38N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="861" mass="98532" checksum="4BCB9D7D813C21D4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Y3</accession>
    <name>F7K8Y3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252139.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02238"/>
    <dbReference type="EnsemblBacteria" id="EGN41145">
        <property type="protein sequence ID" value="EGN41145"/>
        <property type="gene ID" value="HMPREF0994_02238"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2443"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106729_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="16984" checksum="78BDCDADF7BECF7D" modified="2011-09-21" version="1">MRVEIKVEPDCRDPYAVLHIARLTPSLQTAVSLLEREGDEILFSAQRDGKTYLLDPDTIDLIRTEGRELVLYDRQKKRFLLSRPLYELEKQLGSSFVRISKSAIVNIRQISHVEASFNGTMELVMKNGAEEVITRSYRKQFKERLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Y6</accession>
    <name>F7K8Y6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252150.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02249"/>
    <dbReference type="EnsemblBacteria" id="EGN41156">
        <property type="protein sequence ID" value="EGN41156"/>
        <property type="gene ID" value="HMPREF0994_02249"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2455"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068384_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="320" mass="35176" checksum="B8F3E6A243CAA650" modified="2011-09-21" version="1">MHREKENSSVHGLLVLFRKELADHLRSTRFLLMTALLTLTSMASLYGALSNIRDQATENSEFIFLSLFTTSGNSLPSICTFLAFLGPLAGIVLGFDCMNRERSLGTLNRLTAQPIYRDTVINGKFMAGFAAIFLMVFSLGILVSAIGLLVIGIAPQTEEVLRILAFLLFTVFYIAFWLGLSILFSVIWRHAATAALAGISIWIFLSFFMSMIAGAVADIAYPTEGIEGLFNLKSNYSLELGLNRISPYYLFGEAASTILNPNIRSIGIVTNSQLSGAIAGYLPFGQSLLLVWPHLVCMVALTMVCFALSYICFMKQEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K942</accession>
    <name>F7K942_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252281.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02380"/>
    <dbReference type="EnsemblBacteria" id="EGN40779">
        <property type="protein sequence ID" value="EGN40779"/>
        <property type="gene ID" value="HMPREF0994_02380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2605"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="238" mass="28430" checksum="228ADF2FFFEB33D6" modified="2011-09-21" version="1">MLKIALVDDNTDFLLLLRKKVHTFFDGRNVLCEVRLFPNPEVFYFDLEEGFHYDICFLDIEMPQMNGLDLAKKIRASAQATYLVFITSYLQYAVEGYEVKAFSYIPKNLLEEKLEATLLGIFGEMQEKNEKYYFVETNSRFERIEYKEIIYVYKNNKNAVFVLKDREVPVRKTLQEVFLQLDSEEFICIERGYIVNIEHIIKLENKEITLRNGKKFQVGRTHIREVKETIHGYWRDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K944</accession>
    <name>F7K944_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02382"/>
    <dbReference type="EnsemblBacteria" id="EGN40781">
        <property type="protein sequence ID" value="EGN40781"/>
        <property type="gene ID" value="HMPREF0994_02382"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020211_9_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c_5" evidence="1">
        <location>
            <begin position="75"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="180" mass="20753" checksum="6C57225B250B8167" modified="2011-09-21" version="1">MKNHLSVLSLLIADRNLDRAEEYIKKVNAPILELEHKKYTGNRIVDIILNDKIEKAHNNNIKFIINAHDIKEGIIQDIDWCAILANILDNAIEACIKVQNDEKWIEMSISQNDCSTIINVTNIYNGEIKISKDKLESTKKNKILHGIGMESVKTAVNKYNGIFEYNWEADIFYIYISLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9H7</accession>
    <name>F7K9H7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02538"/>
    <dbReference type="EnsemblBacteria" id="EGN40937">
        <property type="protein sequence ID" value="EGN40937"/>
        <property type="gene ID" value="HMPREF0994_02538"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2782"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034454_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="427" mass="47394" checksum="5DC506CF3BE121ED" modified="2011-09-21" version="1">MSKTALVLAGGGSRGSYELGVWQALRELDIDIHIVTGTSIGAINGAVIAQGDYDAAIWLWNNIGNNKVIDTPVDEDVSLEQKIWATYQCYLVNFVKNGGTEVNSLKETLALFLDEQKVRASSVAYGLVTIEMDSQIPHELFIEDIPEGKMLDYILASASIYPAFKPHTINNVRYVDGAYHDNLPVKMAFDKGATDIIAVDLDAFGVVNKDMLKHAEHAVYIKSYWNLGPTLVFDHVTIQRNIRLGYLDTLKAYGAYEGYAYTFLPGFCEKNISKFSDCLPLEDFLCRSGDGVFDQLFHKSLYKIIEERCGQKNNDYAVVLACAELAGEIFGLNCTVIYTYEVWQQRLRQSVAETPLPNISNSTEVNLLDSVLESAQTIVNRRSRTKLVAAMIKELIQTESTIWPAASLIVLPETFLAGLFLAVTGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9N4</accession>
    <name>F7K9N4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252403.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02502"/>
    <dbReference type="EnsemblBacteria" id="EGN40901">
        <property type="protein sequence ID" value="EGN40901"/>
        <property type="gene ID" value="HMPREF0994_02502"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2742"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067890_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="156" mass="18002" checksum="5918DDFBDE3C393D" modified="2011-09-21" version="1">MRRKDREVTDAGKIREAIEASHCCRLGFYDEGEVYIVPMNFGYTEEEEKRIFYFHSAKEGRKIELISRTHSAGFELDTNYQLHEGEKACQYSAGFLSVIGTGNIDFVEDRESKKSALQTIMLHNTGKSNWEFSEDMLDAVLIFKMEVTQISCKEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9U6</accession>
    <name>F7K9U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252530.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02629"/>
    <dbReference type="EnsemblBacteria" id="EGN40612">
        <property type="protein sequence ID" value="EGN40612"/>
        <property type="gene ID" value="HMPREF0994_02629"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2884"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="31430" checksum="2572CF257F6146D7" modified="2011-09-21" version="1">MKKGQQKGTQRVNWPVTILLILGSLTIFFPLYMAIVIAFKSPSEMTNDIAGILSLPSAFRLDNFTEAMRVTDFWHSLGNSLLITCTVILIAIAVHSLAGYAIGRNMAHSRFYNIAYLYIVSGMFVPFAILMMPLVKQTAQIGLANRVGVILLYVVFYMPMNLLLYSGYLKNIPLALEEAARVDGASTWETYWKIIFPIMKPMHATAAVLTALGTWNDVMTPLVIMSGTGHNTLPLAQLNFQTQFGTNYNLAFASYLLALLPILIFYLFCQKQILNGVVNGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA44</accession>
    <name>F7KA44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0994_02729</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252630.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02729"/>
    <dbReference type="EnsemblBacteria" id="EGN40712">
        <property type="protein sequence ID" value="EGN40712"/>
        <property type="gene ID" value="HMPREF0994_02729"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2986"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="302"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="421"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="518"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="830"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN40712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="878" mass="97081" checksum="259E12FF4A8302F0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAC5</accession>
    <name>F7KAC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252652.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02751"/>
    <dbReference type="EnsemblBacteria" id="EGN40360">
        <property type="protein sequence ID" value="EGN40360"/>
        <property type="gene ID" value="HMPREF0994_02751"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3009"/>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116623_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="144" mass="16666" checksum="E500AEEC9DF86DEE" modified="2011-09-21" version="1">MAVKTDTEVIIGGKVFTLSGYESEEYLQKVASYINNKMSEYSKLDSFRRQPVDRQNVLLQLNIADDYFKARKQIALLEEDIRAKEKELYDLKHELIASQIKLENSEKSLKGLQRDLNESSKKIIRLETELADNKKKGNGDPRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAG4</accession>
    <name>F7KAG4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252691.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02790"/>
    <dbReference type="EnsemblBacteria" id="EGN40399">
        <property type="protein sequence ID" value="EGN40399"/>
        <property type="gene ID" value="HMPREF0994_02790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3053"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="458" mass="49290" checksum="5F3C1BF3EFBC1392" modified="2011-09-21" version="1">MKATQEKEADLGNSSIGKLLFKLALPAILAQIINVMYNMVDRMYIGHIADVGPSALTGVGVTMPLIMAISAFAALVSMGGAPRASIMMGKGDKETAEKILGNCTTMLVLMAVVLTAVILLFGKPILLMFGASDNTIGYAWDYMSIYAMGTIFVQISLGLNAFINAQGYARTGMLTVAIGAVCNIILDPILIFGFDMGVKGAALATILSQAVSFVWVLRFLTSGKSFLRIRKGYLKLSADIILPCIGLGVSPFIMQFTESIISVCFNTSLLKYGGDIAVGAMTIMTSVMQFSMLPLQGLTQGAQPIISFNYGAGNIERVKKAFRLLLASSLVYSTLLWAIAMFLPHVFIAIFTSSAELSAYVTWSIRIYMAASLLFGIQIACQQTFIALGNALTSVFLALLRKVILLIPLIFILPALLPDKVFGVFLAEPVADTIAVTVTGILFLREYKRLSHKKVGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAH3</accession>
    <name>F7KAH3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02799"/>
    <dbReference type="EnsemblBacteria" id="EGN40408">
        <property type="protein sequence ID" value="EGN40408"/>
        <property type="gene ID" value="HMPREF0994_02799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="337" mass="39050" checksum="46C5C56FD1D7DAF3" modified="2011-09-21" version="1">MPERNRKVRKENGMDDNFVKNETVQICSRTHLNITFNIFQCGNFDVEPGKCFTTAEDDVFIMFHVNSGAGLLETKPCTSGVEEGFGFVVFPDVTYRLSSIGEETMNITWVAFSGYRAEDYLGRAAIWPARPVFEDVGGKFGKKMNRLYMLSHEPTNRYCKMASVLYDIFGYLRDMRSPVIEEGYKENLNYVAARAVNYIDHNYMHPISVEKIADGMGITRKHLCHVFHKVLNVTPRQYIIFYRMEKACKMLRSTQQSVQEIAEAVGYANQFYFSKEFKRIVNMRPTEYRKSSGEIEIFTWHSFEATLMNNYKFGTEAEDEDWSVKIEPLTELPGYDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB29</accession>
    <name>F7KB29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03058"/>
    <dbReference type="EnsemblBacteria" id="EGN40235">
        <property type="protein sequence ID" value="EGN40235"/>
        <property type="gene ID" value="HMPREF0994_03058"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50333HZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2192484_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="106" mass="12287" checksum="346D59A21D0B6A68" modified="2011-09-21" version="1">MLIHTDNDINYNHETEERPKKNRKEIACCSWTTASGQIIPILFKMQDEEGLVRTFSKIHVNHSSKKLYAGIPSYEFDCDVLVNGLVVNVLLQYYPEDSRWTLSEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBW3</accession>
    <name>F7KBW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03360"/>
    <dbReference type="EnsemblBacteria" id="EGN40190">
        <property type="protein sequence ID" value="EGN40190"/>
        <property type="gene ID" value="HMPREF0994_03360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3672"/>
    <dbReference type="eggNOG" id="COG4289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028269_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="PTHR35339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="379" mass="43036" checksum="AAA3B8E63392582F" modified="2011-09-21" version="1">MENQRRKEWLESMLRIVSPVFDALEKEELHKTMPLDFHEERSEYAPLEAFGRSMLGLAPWLEAEGLEEEEEKLQAVWRKKALRCLDAATNPESVDFMNFTTGGQPLVDTAFLCHALVRAPKQLAGKLTERVRHNLAEALRSSRTIMAGSTNWLFFSAMVEAGLYLLGEEDYDKMRIAYALRSFEGWYKGDGVYGDGEMFHWDYYNSFVIQPMYVDLLELFGDSAEEYRILKEKVMARASRYASVLERMIAPDGSYPVIGRSICYRFGAFQMLAQAALQHRLEKGLAPAGVRCALTAVLRRCLENGDMFDEKGWLRPGVYGFQPELAEGYINVGSLYLCSAVFLPLGLPAEDSFWTGEDEDWSGRKVWSGGHIAIDHALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC31</accession>
    <name>F7KC31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253311.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03410"/>
    <dbReference type="EnsemblBacteria" id="EGN39917">
        <property type="protein sequence ID" value="EGN39917"/>
        <property type="gene ID" value="HMPREF0994_03410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3728"/>
    <dbReference type="eggNOG" id="ENOG5032988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116627_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032360">
        <property type="entry name" value="DUF4869"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16163">
        <property type="entry name" value="DUF4869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="145" mass="16411" checksum="444267DC54EF90D4" modified="2011-09-21" version="1">MLHIFYGEMADVIYNTSVYFKNVYEDEWITDSFTKEMIMDIDKSRVLDNAVIDSPVMGKIAPTSLSGGVKTLILMNYEPEKVFNASACGDNCAKWILKIAQEKELTINLRHIMDFGKGSFTIHILNTGEIVHNMKELIPIAGLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC43</accession>
    <name>F7KC43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253323.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03422"/>
    <dbReference type="EnsemblBacteria" id="EGN39929">
        <property type="protein sequence ID" value="EGN39929"/>
        <property type="gene ID" value="HMPREF0994_03422"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3742"/>
    <dbReference type="eggNOG" id="COG1402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="28739" checksum="3EE0A1C44C1E86F4" modified="2011-09-21" version="1">MIKKWENLTRDEIAALDKDKSIVLLPTSATEQHGAHLPVGTDAIILSTLVDKMVNECEFEEGNLIFAPQLNVGKSNEHMGFAGTITFGTQTYYSLLHDIAAAISASGFKKLVLFNSHGGNTDMLNMISRDLRIDLGLDVFVFDWWFTPFWNDGLKDLQQSGKYGVFHACELETSLMLAARPETVHMELAVDEEPVDCFKGEKYVTVFGPINAGWKTKDVTNSGVIGAPTFATAEKGHKLFDYACKKLLDILHEIAEISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCH5</accession>
    <name>F7KCH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter, permease CbiQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03557"/>
    <dbReference type="EnsemblBacteria" id="EGN39466">
        <property type="protein sequence ID" value="EGN39466"/>
        <property type="gene ID" value="HMPREF0994_03557"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3886"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="290" mass="31897" checksum="DB300AC8DDD97E13" modified="2011-09-21" version="1">MSSFGELICVGCLYTQEGISVVQAVFFMSCRLQGKENMKIDYYAYHSGMNGWNAGLKMLLAVGTLCLTIALDKPAVSLFVLLTMSLLTLIKGKIPGKAYLHFLSVPLAFVIMSGAAIAADFSRSPLGDWNLHLFFFYLCFYRSSLLLAGAVFLKAMAGISALYMLSLSTPVNQLVLVLQKLHLPSLLVELMNLIYRYIFILIDAADQMQTAAKARFGYVTFRQSCRSFALVAGNLFLVSLKKAGTYYDALLSRGYEGRLEFLTEETAPAPGQLVFTGVYLLTVIVLGCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCN8</accession>
    <name>F7KCN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253518.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03617"/>
    <dbReference type="EnsemblBacteria" id="EGN39212">
        <property type="protein sequence ID" value="EGN39212"/>
        <property type="gene ID" value="HMPREF0994_03617"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3950"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="472" mass="54871" checksum="C2D4089A702036BF" modified="2011-09-21" version="1">MKKPNLIYIFADQLRFNSVGYNGDTNAETPNIDAFCKESTNLCQAVSGHPVCAPYRASLFTGKYTTSTGMVINEIRMNTNHHTFADVLNENGYETAYIGKWHMYANEWGNHYDPKNSYIPEGRDRLGFNDYFAAYNFRHEYAVGTAYYHLNSPEKIYYDKYEPDAQTDMAIEQLHRLSEKDTPFALFLSVGTPHDPWVKENVPPQYYEKFKDKQFSLPPNYLPENDPYADAWAKLSEEERTELTEWMRVYYAMAANLDDNFGRIMEAIKKMGLDKNSIIVFTTDHGELFGAHGRRAKNIFYEEAVRVPFLIKWDGYLEEGAKRDFVLNTVDIMPSLLSMMGLPVPEEVEGTDLSRCMEGKEDTQEGALMMCTGPTADFEDGHEWRAYRDKRYTFAVYKVDGKKLLFDNLEDPYQMNNLAEDPAYSQIAEQMERRMREKMAAIKDTFENTSYYKENWIEDRLIMRTATVNCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCW0</accession>
    <name>F7KCW0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253590.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03689"/>
    <dbReference type="EnsemblBacteria" id="EGN38853">
        <property type="protein sequence ID" value="EGN38853"/>
        <property type="gene ID" value="HMPREF0994_03689"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4027"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="28003" checksum="AAF1DB707335949F" modified="2011-09-21" version="1">MLQVQHLTKSYKTGTQLYPVLKDISFEVKKGEFVAVMGPSGSGKTTLLNCISCFIPHDEGKILLGDQDISGLKEDELARVRNEKLGFVFQDFMLLDGLTVFENICLPQIIAEKPAAQMEAKAGNFCHIFGIDKIMDKYPAMISGGEKQRTAVARALMNQPYMILADEPTGNLDSKSCRAVIDSFLQAKKELEATVFMVTHDTFAASFCDRVIVLKDGCIYRELIRSQTRREFMDVLLDTIRELGEDDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD92</accession>
    <name>F7KD92_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253722.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03821"/>
    <dbReference type="EnsemblBacteria" id="EGN38586">
        <property type="protein sequence ID" value="EGN38586"/>
        <property type="gene ID" value="HMPREF0994_03821"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZF82">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2734845_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="71" mass="8304" checksum="F3AD8DFC12F07878" modified="2011-09-21" version="1">MYIDETIVLDKNLPTELLGDFEELGKYYEAGDWLNFDLLFEVVEASAKSYYLSGRISRRELDKIFKKYGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDM6</accession>
    <name>F7KDM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253872.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03971"/>
    <dbReference type="EnsemblBacteria" id="EGN38736">
        <property type="protein sequence ID" value="EGN38736"/>
        <property type="gene ID" value="HMPREF0994_03971"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4326"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="33999" checksum="9FAFFE7F2454413E" modified="2011-09-21" version="1">MNTVIIDGLSFALPLFIMAIGGIYSEKSGITNLAIEGLQGFGAFTGALAAVLVAGSFSGNSVMPFYIAMLFAVIGGTLFSLIHALLCIRFKANMVISGVVINILAMAMTSFLTKQINAAVFGAASDKFVLGVSSRLTVPVISKIPVLGAVFSNIYPFEIVIVVVALIAWFVMYRTRFGMHLRACGDNPHAVDAAGIEVGKVRLVAVMVSGALSGLGGICFAYSISANFSNNIYVGYGYLAIAAMIFGNWKILPTLGACLLFGLARSGGYRIVQIMEMPSSYQDLVMILPYVLTLLLLVFFSKHNRAPRALGEIYDKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDS2</accession>
    <name>F7KDS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04001"/>
    <dbReference type="EnsemblBacteria" id="EGN37690">
        <property type="protein sequence ID" value="EGN37690"/>
        <property type="gene ID" value="HMPREF0994_04001"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4358"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN37690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="28594" checksum="273991C237B2DAFF" modified="2011-09-21" version="1">MGGGNKILLQVENIEKYYGNQGSVTKALNQLSFHVREGEYISIMGASGSGKTTLLNCLSTIDAVSAGHIILDGRDITDIRENEIAEFRRDNLGFVFQEYNLLDTLTLEENVALPLTIKGLDPEEIDKRVRDTADKLHISDVLEKFPYQVSGGQKQRCAFARAVICRPKMIMADEPTGALDSHSSRVLLEIIAQLNKDMGTTIFMVTHDAFCSSYADRILFLKDGKIFNEIRKGEKTRSVFYHEILDVLSLLGGEGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE43</accession>
    <name>F7KE43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254023.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04122"/>
    <dbReference type="EnsemblBacteria" id="EGN36915">
        <property type="protein sequence ID" value="EGN36915"/>
        <property type="gene ID" value="HMPREF0994_04122"/>
    </dbReference>
    <dbReference type="GeneID" id="29729192"/>
    <dbReference type="HOGENOM" id="CLU_2633564_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="77" mass="8874" checksum="7BE6D60EE15758E6" modified="2011-09-21" version="1">MHTIMKSDETIKQFMPRSGQPVDVIGQLVPVYNDSEWETVELLSGKKEGIEADRSRREWGLEKALWMLPFIGKKNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE59</accession>
    <name>F7KE59_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="5" type="ORF">HMPREF0994_04138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254039.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04138"/>
    <dbReference type="EnsemblBacteria" id="EGN36931">
        <property type="protein sequence ID" value="EGN36931"/>
        <property type="gene ID" value="HMPREF0994_04138"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4510"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_9"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="165"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN36931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="263" mass="28236" checksum="F043EE9EFB837863" modified="2011-09-21" version="1">MKELKIGFIGYGNMAQAIATGLIASKAAAGSRMCACAGNFDKLCRNAEKRGIVPLRTAEEVIENSDFVILAVKPYMVEAVVEPIKGRLKDKTVISVAAGYDFERYEEILEPGTHHISTIPNTPVSVCEGIFVCENRHSLSGEELDAFVSLFQKISLIEFVDSVHLSSAGTLSGCTPALTAMYMEALGDAGVKYGISRETAYRMAAQMIVGTGKLYLEKGTHPGAMKDMVCSPGGTTIRGVSALEKRGFRGTVIDAIDAIEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEM3</accession>
    <name>F7KEM3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254203.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04302"/>
    <dbReference type="EnsemblBacteria" id="EGN36114">
        <property type="protein sequence ID" value="EGN36114"/>
        <property type="gene ID" value="HMPREF0994_04302"/>
    </dbReference>
    <dbReference type="GeneID" id="29723653"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945883_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="288" mass="32576" checksum="D3CCFF1EE7F20DCA" modified="2011-09-21" version="1">MNLGISGQALGDVMDFEAIVDIGLKYGIRHYELWPCNVPGTGFGYRNRDIEKVCEIIRRKDVVIDCVTMEAAFCKAAVESPEYYAELLMGAIDAAVTVGANLVNHYCYYINLEEEPDFERMESYWSRPLAYAKEKQVMLVLENEAHDATRRPELMTAIMEHFQDEAFRTNLDAVNYFHASEEGFPAAYEILKPYIGYVHLKNACLYREGAGRPKENEGAPMSGIYAGRPIQYAPIPDGSVNIAGLVHALKEDGSYIGTCTLEPHTTPECAEAFYEREIKWLRELNLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEN2</accession>
    <name>F7KEN2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254212.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04311"/>
    <dbReference type="EnsemblBacteria" id="EGN36123">
        <property type="protein sequence ID" value="EGN36123"/>
        <property type="gene ID" value="HMPREF0994_04311"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4708"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="32392" checksum="77D7A81ECA5A2546" modified="2011-09-21" version="1">MTIQNYGTFGFLNPGQLPDEPLLLLDFGIEKRQAEPYDFNNNDRDYDGYLFQYTFQGRGIFERDGISSPLLPGTAFFSLIPEKSRYYLPEEEPDNCWEYFYVHFQGPAALPFFRKIRDSFGYLLSLPSDSVPVQMWLNLHEDMGKGRQLRRYEGGELVYRFLSSLLRTLESPAMPGLSACVEDSILYMKEHFSEHFSIEELAGLKGLSSAYFTRLFTRETGQAPLSYLTDLRLTHALSLLLNTSLSVEAIARACGFSCGNYFCKVFRRASGCSPAEYRRRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEP4</accession>
    <name>F7KEP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254224.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04323"/>
    <dbReference type="EnsemblBacteria" id="EGN36026">
        <property type="protein sequence ID" value="EGN36026"/>
        <property type="gene ID" value="HMPREF0994_04323"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4720"/>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="384" mass="44421" checksum="408BDBE9E4C5E948" modified="2011-09-21" version="1">MDYQKLTQGEIKQALDFSAAQIKKYLPQFTDKFQNAYSVNHFYEPIDNVDWTNGFWTGEIWLAYEHTKDEAFRKAAEIQVKDYLRRIDNKIMVDHHDMGFLYTPSCVAAWKLTGNRTGREAAIKAADQLISRFHEKGEFIQAWGAMNAPENYRLIIDCLLNLPLLYWASEETGDSKYRDIAEKHIHTALANVIREDGSTWHTFFFNMETGEPDHGATCQGYRDGSAWARGQAWGVYGTALGYRYTKEAKYVDAFRTVTGYFLDHLPEDLVPYWDFEFTDGSDQPRDSSAAVIAACGMLEMAKYLPEEDADYYRTKASEIMKSIYDNYAVKDHETSNGLVLHSTYSNHSPYNTCNHCGVDECNSWGDYFYMEALTRLSKDWEQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEZ2</accession>
    <name>F7KEZ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35738.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359931.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04428"/>
    <dbReference type="EnsemblBacteria" id="EGN35738">
        <property type="protein sequence ID" value="EGN35738"/>
        <property type="gene ID" value="HMPREF0994_04428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="219"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN35738.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="412" mass="44956" checksum="1791E6CB6579B4DA" modified="2013-09-18" version="2">MLINKKSKFLSADSVFFFSACIILFLINQLYSVLQVSLIMKSTGSILLLSSVMTAMVIPRIFILPVSGFLTDKLGIFKTLIIGTGLLGLLLISLFLVNQGSLVNENIIFIFAVLFGGISAAILPALYSAISVLMGGEHLQKANSVMQFINQGATLIGPLLAGFLVEKTSDKAYPIMAVSALTAFFLFCRVSFRENRQEKDKAHESGASQQGAFKDLLEQPILILLLIFTALLNLCIIGPQQVGFPVIAMNCLSEGVEGYTRLLSVTGLGALVSAVFIGNIKRRESMQSIHLILWCSLILGMIWSIFSYSSSRLIIMVSIFAAGLLLGIINVLFLTTIQQLTPAFLVGRVMSIQFLCSTGLQPVSYMITGILLDKFNINNLYLISGGIISLLSILILVYSKKNTKWMRRVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF91</accession>
    <name>F7KF91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254344.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04443"/>
    <dbReference type="EnsemblBacteria" id="EGN35753">
        <property type="protein sequence ID" value="EGN35753"/>
        <property type="gene ID" value="HMPREF0994_04443"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4852"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043516_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="54823" checksum="421CC86041139C11" modified="2011-09-21" version="1">MDQIKLYNIAYKYLFNCIHFGLYPTGSSLPTIPELCRAFNVSSSTIHSALRLLQEDNYISLSQGRSAVVTYDITEEECQRKYRLYSYAAKDALLDLCGTMLLIWPEVMLQGLKLCGDDDLKKLNEIYCRMSPYTEYPYYEFFLHILKALGNPLFVNLYQSTIFFGHPSIMHLGDKAYVYGYMTYLKRATAQILSLCKASDYGPLKALLISLYQKQIEEIRLYHNSLPVPDCPVEPISYEWNYFSERPLVNFNLAMKLLRKIYSSYGNQEFLPSYGALAKQYSMPLITVRRSVKILSDLGIVEAIPGKGTRVLVGLDNPAPLSKFTSPNLKKALLQYLQSMQIILIICKDVALSVFPGLPDSSIQDTITWLQNIQISGDYYMTFGVCFGLLNEKAQSPALRQILGGLMYFQYLGYPLNDRKPYAFRFDSRSTSMLLKSLEEKDAGLFASQLQCLALDIFKAGKEKLITGGIREAESIMLPLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFA9</accession>
    <name>F7KFA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04538"/>
    <dbReference type="EnsemblBacteria" id="EGN35307">
        <property type="protein sequence ID" value="EGN35307"/>
        <property type="gene ID" value="HMPREF0994_04538"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4955"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054920_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="421" mass="48684" checksum="ADDF018C2C941F52" modified="2011-09-21" version="1">MNRRLEDKTILKVNMLGGFSLVYGNKPVPNNYSGTSKMMQLFQILLYAGREGISRGELIDRLYGREDLEDAGATLRVNIYRLRKYIQKLKCFENDDCIWFQEGVYRWNYTAVPLERDTDHFNTTAEAALKEENPEIKMELLKEACRMYRGEFLPELAGEEWVAIESCKYQKLYVDCINEAAVLLKENGQFAELLELSSQASSIYYFEEYYLMQIDCLMALGRYKEAMEIYETAAAFYFEELGLEPSEEMLDRFRQMRDKIHYNASVISDIKHGLQEGENNNGAYFCSYPGFVDCYHIVCRMSERSGQPAFLMLCTLVDSEDVPLTEEARLGNYMDKLKSAIRSALRRGDSFTRYGNNQFLVLLVGIKQENCAITQSRITNCFLSYGLRGKISVRYEIYPATEEEGTAGNLLFHQNNDWQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFD8</accession>
    <name>F7KFD8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35336.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359946.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04567"/>
    <dbReference type="EnsemblBacteria" id="EGN35336">
        <property type="protein sequence ID" value="EGN35336"/>
        <property type="gene ID" value="HMPREF0994_04567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35336.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="278" mass="31921" checksum="96C1E745CFFFBEDF" modified="2013-09-18" version="2">MRHTKKYKIQTAVRVTVLWLFALICLAPFYVAVCYAFKSKTEFAKTKLAFPTTLYLQNFVDAFELKNYFNSVKNSAIVAICVVILIVIICSMSAYIITRKNNKFYNFIFYFFQMVILIPFQTIMFPLYRELYSLHALSTLWGLVFTELGVYMGYYIFLYAGFIKSVPIALEEAAKIDGCDRYQVFVRIVFPLLKPITMTVVVLCFLASWNDFFLPLIMVQKDEVKTLPLMQFFFFGEYTSNINLAFAASILSMIPAVAVYFCAQKYIVAGMTAGAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFI4</accession>
    <name>F7KFI4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254514.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04613"/>
    <dbReference type="EnsemblBacteria" id="EGN35060">
        <property type="protein sequence ID" value="EGN35060"/>
        <property type="gene ID" value="HMPREF0994_04613"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526332_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="296"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="607" mass="69463" checksum="98E6D3E48CCFC9FA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFP3</accession>
    <name>F7KFP3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254573.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04672"/>
    <dbReference type="EnsemblBacteria" id="EGN34883">
        <property type="protein sequence ID" value="EGN34883"/>
        <property type="gene ID" value="HMPREF0994_04672"/>
    </dbReference>
    <dbReference type="GeneID" id="29724995"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5103"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356602" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="104"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="580" mass="64856" checksum="FFBECDA7B5170862" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFR9</accession>
    <name>F7KFR9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34624.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360145.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04698"/>
    <dbReference type="EnsemblBacteria" id="EGN34624">
        <property type="protein sequence ID" value="EGN34624"/>
        <property type="gene ID" value="HMPREF0994_04698"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34624.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="287" mass="32323" checksum="E93A1027C1432D92" modified="2013-09-18" version="2">MSGEKEVDYRKEKLKSRIAWAIAIFFACAWLVVTLVPFFFMIMNSFRKQFDMLAQGVFHLPHPWYFNNYVEVMTHGFFGYFFRSVLVVAVSLILMLVISAFAAYPLSRMKFKLRGFIYAGIVAMMSIPMHVTLIPIFKMTTNMGLYDSLQALVGPYVTFALPMSVFILTAFMTTIPKEIEESAEIDGCNKFRNFFAIILPLSKSGLSTLAIYNGVSMWNEFAFANTLLQTASNKTLPLALGQFKGEHSLDIPIILSVLVLSVLPMIILFITFQDKLVKGMMAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFU8</accession>
    <name>F7KFU8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254628.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04727"/>
    <dbReference type="EnsemblBacteria" id="EGN34653">
        <property type="protein sequence ID" value="EGN34653"/>
        <property type="gene ID" value="HMPREF0994_04727"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5159"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="493" mass="57656" checksum="31768CFAD9503E7D" modified="2011-09-21" version="1">MKAIMIMYDSLNRHMLAPYGCEWTKTPNFERLAERCVTFDKCYVGSLPCMPARREIHTGRYNFLHRSWGPMEPYDDSMPEILKRNGIYSHLISDHYHYWEDGGCTYHNRYSSWENVRGQEGDPWKGCVGDKVLPAHIGQCGKQDMVNREYTDTEDRMAQSVTFRAGVEFLERNHGADNWFLQVETFDPHEPFYVQDEDLMGFEAEYDGPLFDWPGYHRVTEEERPYVQHVRNKYAALLQMCDRNLGKILDKMDEYNLWEDTMLIVNTDHGFMLGEHDWWAKSNEINFYEEIVHTPLFIYDPRSRAAGRCECLVQTIDLAPTLLEFFGLPIPGDMLGHVLKDTIAEGKPVRETCLYGTCGAQISCTDGHYAYVLAPAVKTNEPFYNYTLMPTHMREMFPPEELQGLELSEPFSFTKGCRLLKIKNVEKREYTNGLGEHPYKTLLFDLEKDPKESEPISNPEVEEYFRKEMVRIMKENDAPKEQYVRMGLEREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFX6</accession>
    <name>F7KFX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04755"/>
    <dbReference type="EnsemblBacteria" id="EGN34681">
        <property type="protein sequence ID" value="EGN34681"/>
        <property type="gene ID" value="HMPREF0994_04755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5192"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="169" mass="20357" checksum="DF43A4D06F5A6653" modified="2011-09-21" version="1">MEKYDKSIDMDSVYREYEKLVYRFLYSHTHDAEWSQELMQETFLRAVNSISRYDGTCKLSVWLCQIAKHILYQELRKKKQIETVELVDCLTDDSAPNGETSILKQESKIELYREIHLLPEREREVVLYRITGELSFREIGEILGKSENWSRTVFYRAKQKIREELKKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGA5</accession>
    <name>F7KGA5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04843"/>
    <dbReference type="EnsemblBacteria" id="EGN34470">
        <property type="protein sequence ID" value="EGN34470"/>
        <property type="gene ID" value="HMPREF0994_04843"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3169377_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="47" mass="5462" checksum="C7B32F3214F3D88D" modified="2011-09-21" version="1">MNNDRNNYMITAGDLEIERESMEVSLDMDKDERAVTINTPYLSIFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGT7</accession>
    <name>F7KGT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254967.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05066"/>
    <dbReference type="EnsemblBacteria" id="EGN33099">
        <property type="protein sequence ID" value="EGN33099"/>
        <property type="gene ID" value="HMPREF0994_05066"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5534"/>
    <dbReference type="eggNOG" id="COG2315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105851_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="13582" checksum="C12DC1B322828F41" modified="2011-09-21" version="1">MKTRKEMIAFCLTFKGVYEDYPFHDDNWTVMRCKGNKKTFAYIYERNGLVQVNVKCDPEWIQFWRDAYPGVLPGYHMNKRYWNTVILDGSVPDRDVRRMIKESYELVRPAENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH46</accession>
    <name>F7KH46_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255081.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05182"/>
    <dbReference type="EnsemblBacteria" id="EGN33215">
        <property type="protein sequence ID" value="EGN33215"/>
        <property type="gene ID" value="HMPREF0994_05182"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5663"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="558" mass="65364" checksum="53249D0E1D273C71" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH74</accession>
    <name>F7KH74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05210"/>
    <dbReference type="EnsemblBacteria" id="EGN33243">
        <property type="protein sequence ID" value="EGN33243"/>
        <property type="gene ID" value="HMPREF0994_05210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5688"/>
    <dbReference type="eggNOG" id="COG4859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378029_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025357">
        <property type="entry name" value="DUF4261"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14080">
        <property type="entry name" value="DUF4261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4261" evidence="3">
        <location>
            <begin position="223"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4253" evidence="2">
        <location>
            <begin position="628"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="733" mass="84140" checksum="F57CED7FA360EED8" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH99</accession>
    <name>F7KH99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33271.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002588984.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05238"/>
    <dbReference type="EnsemblBacteria" id="EGN33271">
        <property type="protein sequence ID" value="EGN33271"/>
        <property type="gene ID" value="HMPREF0994_05238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108363_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06908">
        <property type="entry name" value="YpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33271.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="180" mass="20614" checksum="B9B2DE144A447374" modified="2013-09-18" version="2">MNQYACAITGHRPTRFCFGYNEEDPLCQKLKECLLEQFRILHDEKFVRTFFVGGALGVDMWAGEQLLTLRAQTGYEDIKIVVVVPFIGYDSKWPDQSRHRLKKLIQNANDSIVISHSADVSSYKKRNYYMVDHAEYLIGVFDNQKKLRSGTSQTVNYALHQGKVITLIHPDTMEITAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI47</accession>
    <name>F7KI47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571060.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05487"/>
    <dbReference type="EnsemblBacteria" id="EGN32928">
        <property type="protein sequence ID" value="EGN32928"/>
        <property type="gene ID" value="HMPREF0994_05487"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6000"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="263"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="295"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="462" mass="51334" checksum="0796B89250EB9CC2" modified="2011-09-21" version="1">MIEFKNVSFQYEGSEQQIWNVNLSIAQGECVVLTGVSGCGKTTLTRLMNGLAPSYFKGSISGSICIDDRDITGMTAWEIGTIVGSVFQNPKSQFFSSELVGEVAFGCENHGFSREAIQERTDKSIETFSLSLIRKRPLDVLSSGEKQRVAIASVYAMRPKVFVCDEPTANLDLGGIEQLLGTLFKLKAQGYTLVIAEHRLSWLSELADRIIYMEKGRIVREYTPKEFTAMPEMERRNKGLRTMHRVQTREPLPLPKLFERGSLIMHDLCKKCGEIEVFTNLSGAFPQGSITAVTGRNGAGKSTLALVLAGLSKKSGGDIIVCGSKNHLSRRRKKVYYCGNDTTTQFFTASVSEELLLNQPLSEERMERARQLLKNMNLYEYRDVHPAALSGGQKQRLAVACAIFSEREILLLDEPTSGLDGANMRRISDALKAAASRGKTVIVITHDPEFMEECCQYCFSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIG5</accession>
    <name>F7KIG5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255451.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05644"/>
    <dbReference type="EnsemblBacteria" id="EGN32268">
        <property type="protein sequence ID" value="EGN32268"/>
        <property type="gene ID" value="HMPREF0994_05644"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6169"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="579" mass="66118" checksum="622670DE2DF34747" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIK7</accession>
    <name>F7KIK7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05686"/>
    <dbReference type="EnsemblBacteria" id="EGN32175">
        <property type="protein sequence ID" value="EGN32175"/>
        <property type="gene ID" value="HMPREF0994_05686"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN32175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="239" mass="28417" checksum="2EDA2A003FA4203E" modified="2011-09-21" version="1">MYRIAICDDEINICTGLEEMLQKIMQEFNVQFEIEPWFSGERLCQDLDAGNRYELIFLDIQMLTLNGIDVGKLIRNDLNDFKTQIVYISYHKDYAIHLFKTQPLDFLVKPLAYDAVKDVIRTFLKLEEKKKVFFEYHIGNNYYKQPCDDILYLQSDDKKIQMILFREKKEFYGKLKTIMSQLPSNFLQIHQSFAVNQDYVKEYAYEKVTMINGHTLSISRPYRNIVREKLIRKKEGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIN0</accession>
    <name>F7KIN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidinol-phosphate phosphatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32199.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05710"/>
    <dbReference type="EnsemblBacteria" id="EGN32199">
        <property type="protein sequence ID" value="EGN32199"/>
        <property type="gene ID" value="HMPREF0994_05710"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028110_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32199.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="433" mass="48778" checksum="CCD988DE05484815" modified="2013-09-18" version="2">MAGGRGKRIASLDSSIPKPMFRLCGKPILEYQLQWLKKQEIDEVILVTGYLGHVIREYFGDGTGAAPAGGKTIGIPLKYINEETPLGTAGALYYLKDTMKEDFLLINGDIIFDIDLERFYKAHQTFGGLATILTHPNDHPFDSGIIEADEKGLVREWLHKEDKRKWYGNRVNAGIHILSPGLFLHAERRGLFKQPQRVDLDREILRPLIEDRQLYAYMSPEYVKDMGTPERYRMVERDLLKGKVEKRNLSRRQKAVFLDRDGTMNEYRGYIRTPEDLVLLPGTGKAVKRLNESGYLVIVVTNQPVIARGELTEEQLREIHDRMETLLGEQGAYVDDIFYCPHHPDGGFPGEVASLKIPCSCRKPEPGMLLKASDKYNIDLKNSWMAGDSERDMRAGKAAGCHTAGVGGLQNADFTCGSLAEFVDFLLGREEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIN9</accession>
    <name>F7KIN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255528.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05721"/>
    <dbReference type="EnsemblBacteria" id="EGN32210">
        <property type="protein sequence ID" value="EGN32210"/>
        <property type="gene ID" value="HMPREF0994_05721"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6255"/>
    <dbReference type="eggNOG" id="ENOG5032UEZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709388_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364092" evidence="2">
        <location>
            <begin position="33"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="389" mass="43344" checksum="273F71C0B533B064" modified="2011-09-21" version="1">MKHNTKKWQASLLCITLCGILTACGSGKESQAEDMKNSETIQINETDMGAQQENGTEEETGGMEENRLIGEQTFEVTLEPLGKVTFASYRPDTQQNPLGDALFEIQEAGGKTTALEGIADNNIRANEIFNKVEAVSFPDYNGDGFSDIIIICNYSPSSGPDVGTGYSEARIYRGNEDGLFTLERELSEVTNSALAEKTVQSVLGFLGAGKQGEAQASDWKQAYIDHLQKQDPEEWQGYQLIYLNDDEIPELVEIGTSEAAGCVIVTYADGMLEETRLGRLNFTYIERSGLLCNSDGNMDRYYDLVYRMENGRLTQIAAGYYGAEDNSRVEFDADGNPVYQYQWNDVQMSQEEYEQKLNAVYDTSKARQGYEWDGWLSREEAAGTVESME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIQ6</accession>
    <name>F7KIQ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">23S rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_05743</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32232.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004607971.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05743"/>
    <dbReference type="EnsemblBacteria" id="EGN32232">
        <property type="protein sequence ID" value="EGN32232"/>
        <property type="gene ID" value="HMPREF0994_05743"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="83"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN32232.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="329" mass="37568" checksum="8A40452C915E8A29" modified="2013-09-18" version="2">MKHLPKSTLTEILNDPYGFTYKEMSEVIGEDKARALYAELYKQPFHKKNLSISTKKVYKSSDTEKYVYELKDNRYIETVFIKRRDGGTVCVSTQVGCSVGCIFCESGRNGFVRNLTPSEIVQQVILIRQKVNRIVFMGMGEPLFNYDNLIAAIHILRDRNGLNFPTDGITVSTVGPVNQLKKLREEHLKIQLTISLHAATQAARNCIIPHMHMYAIEDVVKQALSYSQRHNRKVVFAYLLLPGINDRSSDIRQLAKWFKGKNVMINVLQYNPTSNSKIRAPQKQEMVAFKHQLEQTGLEVTMRVSHGREIKAACGQLANTYNKAKKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIS3</accession>
    <name>F7KIS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007037042.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05762"/>
    <dbReference type="EnsemblBacteria" id="EGN32251">
        <property type="protein sequence ID" value="EGN32251"/>
        <property type="gene ID" value="HMPREF0994_05762"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6300"/>
    <dbReference type="eggNOG" id="ENOG502ZC60">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123819_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="15023" checksum="4EC5A01AF428CFA6" modified="2011-09-21" version="1">MAYVPVPKDLSKVKTKVAFNLTKRQIVCFAAALLFGLPLFFLLKDSTGTSLASMAMIAVMLPCFLFAMYEKHGQPLEVVVKNIIRTKFIAPKERPYRTDNFYSVLERQRKLEKEVSAIAKGNTKKQRGGKHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ72</accession>
    <name>F7KJ72_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000016">
        <property type="protein sequence ID" value="EGN31532.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05904"/>
    <dbReference type="EnsemblBacteria" id="EGN31532">
        <property type="protein sequence ID" value="EGN31532"/>
        <property type="gene ID" value="HMPREF0994_05904"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102055_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="13"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN31532.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="222" mass="25648" checksum="26D4C07255E0C8FF" modified="2013-09-18" version="2">MMEIKEEDYLMLSGIQHFVFCQRQWALIHIEQQWAENEHTTAGELLHKNAHDPYFNEKRKDIIISRAMPVVSRSMGVSGECDIVEFRKVPDGISLHGHRGLYQVYPVEYKKGSPKAGNADILQLTAQALCLEEMFSAEVKEGAIFYGETRRRENILFTDELKKKVKDCFCQMHQLYDKRYTPKVKWSKSCNACSLKDICLPKLGKTPNVKEYIHAAITEDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJA3</accession>
    <name>F7KJA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05943"/>
    <dbReference type="EnsemblBacteria" id="EGN31571">
        <property type="protein sequence ID" value="EGN31571"/>
        <property type="gene ID" value="HMPREF0994_05943"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6505"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="172" mass="19806" checksum="086A010498A7A88D" modified="2011-09-21" version="1">MGILLLLPFFLIRFGLLSLLNKEAVGRAAYFAPLQGNEKTACIFYQISNIAIFVYILFLKVSYTPAWLFFTGLAVYIAGVILLLVSVVNFATPSENGINKNGLYRVSRNPMYVAYFVFFLGYVLLTQSLILLALVIIFQISAHWIILSEERWCMEKFGDEYVQYLKRVRRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJF9</accession>
    <name>F7KJF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255764.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05988"/>
    <dbReference type="EnsemblBacteria" id="EGN31342">
        <property type="protein sequence ID" value="EGN31342"/>
        <property type="gene ID" value="HMPREF0994_05988"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6553"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677758_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="403" mass="43076" checksum="AA4C7C2A87307258" modified="2011-09-21" version="1">MENYVVSGKKSVLKSYRHTLYASYLGYITQAIVNNFVPLLFTTFIASYGISLEKITLLVTINFGIQLVVDLLSPRFVDRIGYKTSIIIAHVFAALGLAGLGIFPDLLPDPYVGMLAAIFFYAIGGGLIEVLISPIVEACPFDQKSAAMSLLHSFYCWGHVGVILISTLFFALAGVHNWRILSFIWALVPLLNAVYFCLVPVRSLNEGGDSMSVKELLSGKLFWIFALLMVCAGASEQAMSQWASAFAESGLKVSKTVGDLAGPCMFAVFMGISRAFYAKFSEKINLIVFMTGSGALCVVSYLLASLSPVPVLALVGCGLCGLSVGIMWPGTFSLAAEKCPKGGTAMFAYFALAGDLGCSSGPTLVGMISDAFDGRLTAGLLAAIIFPLLLLAGLRLCKKMTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJJ3</accession>
    <name>F7KJJ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06027"/>
    <dbReference type="EnsemblBacteria" id="EGN31381">
        <property type="protein sequence ID" value="EGN31381"/>
        <property type="gene ID" value="HMPREF0994_06027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="34549" checksum="8944D1979482B366" modified="2011-09-21" version="1">MRTKSKAVKNKAAVRRKLFLISVPFLLFITAFCYVPLLGWVISFFKYYPGIPLNKLEFVGLQNFRFFFSNGEQVLNVVKNTFVLSGLIILTLPLPAVFAILLNEIRAPKFRKLVQTFSTIPYFISYVLLYLAFVTILSPSDGMLNTLLYEKLHVIDQPLNVLTNPKIAWTVQTFTYLFKNIGYSAILYLSAIAGIDTQLYEAAEVDGAGRFQKILHITVPGLVSTFVVLLVLGLGNVLSGAGFEQYYVFGNAMVLDKLEVIDTYTYKMGIVQGNYAFGTAMSMMKSVLSVGLLLIANFIVKKVRGSSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJL4</accession>
    <name>F7KJL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255824.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06048"/>
    <dbReference type="EnsemblBacteria" id="EGN31402">
        <property type="protein sequence ID" value="EGN31402"/>
        <property type="gene ID" value="HMPREF0994_06048"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6621"/>
    <dbReference type="eggNOG" id="ENOG5032YCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169738_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="67" mass="7419" checksum="C48BE5327D8F397F" modified="2011-09-21" version="1">MASSNRSNRVEVPEAKAAMDRFKTEVASELGVNLKEGYNGDLTSKEAGSIGGEMVRRMIKKQEEQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJN9</accession>
    <name>F7KJN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RelB/DinJ family addiction module antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255852.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06076"/>
    <dbReference type="EnsemblBacteria" id="EGN31430">
        <property type="protein sequence ID" value="EGN31430"/>
        <property type="gene ID" value="HMPREF0994_06076"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6654"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154558_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="99" mass="11329" checksum="13F409279316BC18" modified="2011-09-21" version="1">MALATFSVRMDESLKRQFDALCSDFGMNATTAFNVFARAVVRERRIPFEIQASDDITRQDGMQAFMALRAQAKENGVQDLTLEEINEEIRKSRYGEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJT6</accession>
    <name>F7KJT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255891.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06115"/>
    <dbReference type="EnsemblBacteria" id="EGN30741">
        <property type="protein sequence ID" value="EGN30741"/>
        <property type="gene ID" value="HMPREF0994_06115"/>
    </dbReference>
    <dbReference type="GeneID" id="29725635"/>
    <dbReference type="eggNOG" id="ENOG50345W3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146568_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363844" evidence="1">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="138" mass="14662" checksum="4C00AE00A4D00AF1" modified="2011-09-21" version="1">MKTKNLLIVVLVLCLSLGGSITAFAAEVPEPNIEYLNPSPRFKYVMTASVGLKVSSSGAGYTVTINGIDSVNHIVGTVTLYKGSTYVDSANINVYSNYVNKSGSLKTTGTGNYKLTFVGTVYTNNGSEPLSLEITDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJX1</accession>
    <name>F7KJX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255936.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06160"/>
    <dbReference type="EnsemblBacteria" id="EGN30653">
        <property type="protein sequence ID" value="EGN30653"/>
        <property type="gene ID" value="HMPREF0994_06160"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0630">Potassium</keyword>
    <keyword evidence="1" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN30653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="163" mass="18245" checksum="A84AB9D3F5639DF0" modified="2011-09-21" version="1">MKYFDFRLSKKEEKKYVVIIGCGRLGASLAAEIYGQGNDVCIVDRDRDAFRKLDSSYGGLTETGDAADLETLSRVTAEKADCLILVTDNDNINIMISQMAESLFHTEKIVCRLYDPEKECIYRETGIETICPAVLSAREIEKLLGKEKTMGAERSKDEKQCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJX4</accession>
    <name>F7KJX4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_06163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06163"/>
    <dbReference type="EnsemblBacteria" id="EGN30656">
        <property type="protein sequence ID" value="EGN30656"/>
        <property type="gene ID" value="HMPREF0994_06163"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6751"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="286"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN30656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="520" mass="58107" checksum="935B6FC92E763CD4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKI4</accession>
    <name>F7KKI4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">HMPREF0994_06363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256125.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06363"/>
    <dbReference type="EnsemblBacteria" id="EGN47971">
        <property type="protein sequence ID" value="EGN47971"/>
        <property type="gene ID" value="HMPREF0994_06363"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6966"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="180" mass="19824" checksum="3D465976FFD2EAA8" modified="2011-09-21" version="1">MSRIGRMPIAVPAGVTVEIAENNKVTVKGPKGTLERVLPAEMEIKMEGNEIVVSRPNDLKKMKSLHGLTRTLINNMVVGVTQGYEKKLEVNGVGYRAAKSGNKLTLSLGYSHPVEMEDPEGLETVLEGQNIIIVKGIDKEKVGQFAAEIRDKRRPEPYKGKGIKYADETIRRKVGKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKP7</accession>
    <name>F7KKP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256188.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06426"/>
    <dbReference type="EnsemblBacteria" id="EGN48034">
        <property type="protein sequence ID" value="EGN48034"/>
        <property type="gene ID" value="HMPREF0994_06426"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7036"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN48034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="443" mass="51662" checksum="04E2D4F1D3BCB9A3" modified="2011-09-21" version="1">MGAISKAEYERQVSATRDERMRWWRDARFGMFVHLGLYSVYGKHEWAMAMENWPPEEYAKFADGFLAKEGCCREWARLAKSAGMKYMVLTTRHHEGFSLWDSQVNPFNSMNYGPKRDIVREFVDACREFGLKVGFYSTLMEWKHPDSGRCAYDSQARIRFNKYIMELNRELMTNYGKIDVLWYDVPQPMESHEGWNSLELNQMVRSLQPDIIINNRSRLDEDFQTPEGKIVPAGRDWEACMTFNGISWGYLDSRRVRPYSHSAQQIARMLYEVTKEGGNLLLNIGPRADGSIPEEAVEPLQKVGKWIEKNHGFLYGRKDAKQIIYHGSSNVTFEGNKAHVWNFFWPEQDHTIYIAGIQNKLEKAYFLASGTPIAFEQDEYRITLKELPDKEEDELLGITMICLEFDGEVSYWGSGFSRHATRYPQLNRGEVYDPSSFPWPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL97</accession>
    <name>F7KL97_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wzz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256380.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06626"/>
    <dbReference type="EnsemblBacteria" id="EGN46855">
        <property type="protein sequence ID" value="EGN46855"/>
        <property type="gene ID" value="HMPREF0994_06626"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7247"/>
    <dbReference type="eggNOG" id="COG3944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082668_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN46855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="27165" checksum="E0CDAA3299B92753" modified="2011-09-21" version="1">MEENTIRQTDEIEIDLWEICLVLIHNLALIVSVGIMVALGAFLVTQIFGVPKYESTTKIYILNKQENNSVTYSDIQLGTQLTKDYAELIQSRFVLEEVVQGMGLDLSYDEMKKKVSVTTPTDTRILAITVTDTDPVMAMQLANAIREAAAVHIMNVMDIQAVNVSETANMPMDKAGPSVLKNTLIGGVLGVFLMIAIVLVRFLMDDTVKTPEDVEKYLQLSTLAVIPLNEGETDAKKKKKKVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL99</accession>
    <name>F7KL99_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256382.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06628"/>
    <dbReference type="EnsemblBacteria" id="EGN46857">
        <property type="protein sequence ID" value="EGN46857"/>
        <property type="gene ID" value="HMPREF0994_06628"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="116" mass="13204" checksum="0173AC0C3A21E7F6" modified="2011-09-21" version="1">MSDTYNRLAAGERLRLKRTLLGMTQEEMAERIGRVPKYYADIERGSCGMSVETLMALSHSLNMSLDYIIFGNESDNNVQKHQDEISAILDILDTCPDKKRDYALRLLKLFIAACNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLD3</accession>
    <name>F7KLD3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimM</name>
        <name evidence="6" type="ORF">HMPREF0994_06662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256415.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06662"/>
    <dbReference type="EnsemblBacteria" id="EGN46586">
        <property type="protein sequence ID" value="EGN46586"/>
        <property type="gene ID" value="HMPREF0994_06662"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7285"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="95"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="180" mass="20118" checksum="FCF40B202EF5AB0A" modified="2011-09-21" version="1">MEQRLQVGIITASHGLKGEVKVYPTTDDPARFRRLKQVILDSGKETRTLEIEGVKFFKQLVILKFKGLDDINDVEKFRKASLYVTRDNAVRLKKDEFFIADLIDMTVETEDGAVLGTLRDVITTGANDVYEVTLLQGGSVLIPAIKECILEVDVEKARMRVHLLDGLLDLGNDGRGGNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLH6</accession>
    <name>F7KLH6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GlcN6P deaminase</fullName>
            <shortName evidence="2">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nagB</name>
        <name evidence="4" type="ORF">HMPREF0994_06714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256467.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06714"/>
    <dbReference type="EnsemblBacteria" id="EGN46638">
        <property type="protein sequence ID" value="EGN46638"/>
        <property type="gene ID" value="HMPREF0994_06714"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7343"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="3">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="26570" checksum="3432AB9A16441359" modified="2011-09-21" version="1">MKIIKAKDYMDMSRKAANIISAQVIIKPDCVLGLATGSTPVGTYKQLVEWYNKGDLDFSEVTSVNLDEYKGLTRDNDQSYYYFMNDNLFKHVNINKERTHLPDGTEPDSAKACDDYNKVIASVGGIDLQLLGLGHNGHIGFNEPADSFELETHCVDLTESTIKANQRFFASYDEVPKQAYTMGIKTIMQAKKVLVVVSGEDKAEIVKKAFFGPVTPQVPASVLQLHNDVVVVADEAALSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLI7</accession>
    <name>F7KLI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN46649">
        <property type="protein sequence ID" value="EGN46649"/>
        <property type="gene ID" value="HMPREF0994_06725"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3374315_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="34" mass="3910" checksum="8E1ECFFD14C6A24A" modified="2011-09-21" version="1">MEYDIMSKKEFEKMYFFGRLRGLHGNGSEAGHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLJ3</accession>
    <name>F7KLJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06731"/>
    <dbReference type="EnsemblBacteria" id="EGN46655">
        <property type="protein sequence ID" value="EGN46655"/>
        <property type="gene ID" value="HMPREF0994_06731"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7359"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071537_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011434">
        <property type="entry name" value="DUF1535"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07553">
        <property type="entry name" value="Lipoprotein_Ltp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoprotein_Ltp" evidence="3">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoprotein_Ltp" evidence="3">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoprotein_Ltp" evidence="3">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="325" mass="35226" checksum="99C3584E9CE74F71" modified="2011-09-21" version="1">MALIKCPDCGNDFSDQAPHCPSCGYINSNFRQQQSMVPPNPNGSPIPPNNGNYSYAVSPQPVKKESGLGITALIFSILGCTFIVGAILAIIDLCKKDDTKKHTLSKVSLIIAGVWLIIGIIGAAGGGKNTDSSSKLDVIEQESTDTPETETIKIPETTSAETAASSAESENDIETVPAVTSNETTGQKNALRSAKSYLNYSAFSYQGLVEQLEYEKYSHEDAVYAADNCGADWNEQALKSAITYLDYSAFSYNGLIEQLEYEGFTHEQAVYGADNCNADWNEQAAKSAEAYLDYSSFSRDSLIDQLEYEGFTREQAIYGAEANGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLN0</accession>
    <name>F7KLN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256512.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06759"/>
    <dbReference type="EnsemblBacteria" id="EGN46351">
        <property type="protein sequence ID" value="EGN46351"/>
        <property type="gene ID" value="HMPREF0994_06759"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7385"/>
    <dbReference type="eggNOG" id="COG3538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="429" mass="48585" checksum="5D9097F17D93A641" modified="2011-09-21" version="1">MKIPSILINKAKELEEYYKIHYKPLAPLAARCFLNTMETTVKQLEDGSYFVITGDIPAMWLRDSAAQVRPYVKYAAQDRELGDIIEGVIAKQAEFVCLDPYANAFNERADGSGHKDETENNDHVWERKYEVDSLCAPLYLGHAYWKATGVTGIFTPVYKEMIVRILETFITEQDHSRSKYFFTRHDCVKTDTLPAGGKGRPVNVTGMTWSGFRPSDDCCKFGYLIPANMMAVTALGYAEEISRDVYGDVELAGRCKALAEEIRDGIMDYGVVNHHKYGRIYAYETDGFGNYNLMDDANSPSLLAMPYLGYCSREDELYQNTRRFILSEDNPYYNAGSRAAGMGSPHTPEGYVWHIGIIMQALTSTDKKEIGNCLEMLADTHAGTNYMHESFNPEEPEEFTRPWFAWANSLFGELLGTLMEQGFFDGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRI0</accession>
    <name>S2KRI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EPC05049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360300.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07298"/>
    <dbReference type="EnsemblBacteria" id="EPC05049">
        <property type="protein sequence ID" value="EPC05049"/>
        <property type="gene ID" value="HMPREF0994_07298"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="131"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="389" mass="44343" checksum="AAA34EAC6E3D5655" modified="2013-09-18" version="1">MKITDIKIFLVDCYRTNWVFVRMDTDEGIQGVGEGTLEYKEYALEGAVRHLRQYLIGKNPLEIEKHWHDIYRDAYWRGGPVLMSALSAVEMAMWDILGKVLRVPVYQLLGGKIRDQVKIYVNGWFAGAKEPEEFAEKAKDMVKWGVRAMKWDPFGKAYMNISNSELDRALRCVDAVRQAVGKGVDLLIEGHGRFDVPTSIRIAKELEQFKPMFFEEPVPPDNLDALSEVRRKSPVAIAAGERLYGRRSFKELLEKGAADYIQPDVSHAGGIWECRKIAAMSEAYYIPFAPHNPSGPIANAATLQLAACTPNFEILEIMVSDVMWRQDVTNEHLAFQDGCIRIPEKPGLGIELREEACMEHPYIPHDLRHYSGQLTNIRPPQTVRYFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRJ8</accession>
    <name>S2KRJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EPC05069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05069">
        <property type="protein sequence ID" value="EPC05069"/>
        <property type="gene ID" value="HMPREF0994_07290"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_221085_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="32" mass="3940" checksum="0C67B06D3D52D939" modified="2013-09-18" version="1">MKFPRDSHLKKSCFNGEEIENNLYKDIVRWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRY4</accession>
    <name>S2KRY4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4173 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360048.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07146"/>
    <dbReference type="EnsemblBacteria" id="EPC05199">
        <property type="protein sequence ID" value="EPC05199"/>
        <property type="gene ID" value="HMPREF0994_07146"/>
    </dbReference>
    <dbReference type="GeneID" id="29726401"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025121_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="3">
        <location>
            <begin position="295"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="536" mass="61084" checksum="1763093DAF9B7635" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS12</accession>
    <name>S2KS12_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">HMPREF0994_07122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EPC05229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07122"/>
    <dbReference type="EnsemblBacteria" id="EPC05229">
        <property type="protein sequence ID" value="EPC05229"/>
        <property type="gene ID" value="HMPREF0994_07122"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_18_0_9"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="35328" checksum="C5E773F1F8EAF1D0" modified="2013-09-18" version="1">MSSRIEKTDKIYVAGHRGLVGSAIVRNLEAKGYKNIIGRTHRELNLTNQAQVTAFFEEEKPDVVVLAAAKVGGINANNTAPAEFAYENMQIQCNVIKCCHDFGVKKLLFLGSTCIYPKLAPQPIPEDALLTGPLEATNEAYAIAKIAGLEMCKFFKRQYGDDFISCMPTNLYGPHDNYDLQGSHVLPAMIRKFHEAKVNGAESVELWGTGTPLREFLYVDDMADACVFLLENYSGEQHVNIGTGKEVTIRQLAETVQKTVGFDGKIVWNTDMPDGTPRKLTDVTKLHGLGWTHRVELEEGVKLAYDWFKDNIKEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWB2</accession>
    <name>S2KWB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359974.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07109"/>
    <dbReference type="EnsemblBacteria" id="EPC05260">
        <property type="protein sequence ID" value="EPC05260"/>
        <property type="gene ID" value="HMPREF0994_07109"/>
    </dbReference>
    <dbReference type="GeneID" id="29724123"/>
    <dbReference type="eggNOG" id="ENOG5032IW9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031696_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045691">
        <property type="entry name" value="DUF6056"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19528">
        <property type="entry name" value="DUF6056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="455" mass="52622" checksum="EC5638FD4DD1EFC8" modified="2013-09-18" version="1">MRTDKWKKRLFYISILIAFGMIFIFNVLTPVMSDDLFYGKEVSTAGSVWGLIQQEYNQYMTWSGRSVCHLILRLFLTGNKMIFNVFNSIIFVLLTLLIYWNVEHKKKYDLCIFTLINLMLWFFGVVFRQTVLWETGACNYLWGSAIIMSFITCYRYALMHWKDLRHNVLLTILFPVLGVLAGWCNENTSGGGLLFVLILTGIHCYEGRGVRNNIKPWMITGLAGQLAGFLFMILAPGNFIRGQLNEEEHSGIFGLISRFQKMILAVRANFFVLLLIGLLLFVIIKCQKKSWQAVWKVSRNGILWMFIFAATCFALILTPEPMPRAYFGAGVFLTVAVVQFFADVEEKEIIFRSLKSGMIAVMCMIMFFTYMDSGADMARIYREYQEREIYLEEKAAQGEKDVTIPLLRPDFETVYSDAYNSDIQEDPGYWINIAYASYYGFDSVSGIPREDWNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>S2L9X2</accession>
    <name>S2L9X2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAVED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EPC05066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07287"/>
    <dbReference type="EnsemblBacteria" id="EPC05066">
        <property type="protein sequence ID" value="EPC05066"/>
        <property type="gene ID" value="HMPREF0994_07287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046827_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040836">
        <property type="entry name" value="SAVED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18145">
        <property type="entry name" value="SAVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAVED" evidence="1">
        <location>
            <begin position="287"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="490" mass="55622" checksum="B2AB2BC125F039D3" modified="2013-09-18" version="1">MLSQFIKLLLSAEEDVLFHIKMKEVGILGGKEASRGFLYQAFASVLEALCQKNWDKIYIELKSNDDKVDIALEENGRIIKSIQVKSTINTFSKSSIQTWLRDLIRDDVGSAKFELFLIGQCDDNAITFINSIDKFYQGELDAKAKKALIGFDINIIKDKEISFSRLPYDVNILHTIVVASLLRYVSYSKNVMTFDQIDLIASATVNDQMISSTHGKGIDRKEFDEELQKRITLVANSYTPERISIGVKSFICEGGDIEEKTESCLSLTDLFDGRKIKDEYNWNNDVYEKLKGFLFEATSKKQAYQIYLDTHTSIAFAAGRIFNSKMGINIFPMQKTATKGIELWDVKLSSKRNYCNWDILYETFSENQYDTALILNVTRNIHKDVIDFFKENNLTIGRIINCTPSEGGTTNFSIVDGNHAAILANAVYNAISQRTIKERQAVLHIFASAPNAFMFFLGQNSKGFGKCILYEYDFEQRKSCSYSPSIDFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2I2</accession>
    <name>F7K2I2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">HMPREF0994_00061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250010.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00061"/>
    <dbReference type="EnsemblBacteria" id="EGN48294">
        <property type="protein sequence ID" value="EGN48294"/>
        <property type="gene ID" value="HMPREF0994_00061"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.65"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN48294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="33969" checksum="3F95D6B0CA06B928" modified="2011-09-21" version="1">MKIVFMGTPEYAVGALEALWKAGHDIRAVVTQPDKPKGRGKEVQMSPVKQFAVSHDISVFQPVRIKKPEAVEQLKTYEADVFVVAAFGQILSQEILDMPRFGCINIHASLLPKYRGAAPIQWAIINGEEKTGVTIMQMDAGVDTGDMLFKSEVAIAPEDTYASLQDKLARAGADLIVPALAAVEKGEVKPEHQNASDSSYVGMIDKSMGQIDFARPAAETARLIRGLNPWPSAYTSYKGKKLKIWEVSPCEEQTEGAPGTVKKLDKEAIYINTGEGVLKVTQLQLEGKKRMQVKDFLLGCRMEKGEMLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V7</accession>
    <name>F7K2V7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrid_ox_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00186"/>
    <dbReference type="EnsemblBacteria" id="EGN40743">
        <property type="protein sequence ID" value="EGN40743"/>
        <property type="gene ID" value="HMPREF0994_00186"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.198"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133130_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrid_ox_like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="139" mass="16185" checksum="EB15365A079F4C8E" modified="2011-09-21" version="1">MMKNPEQTIGNMADKCSTVFMSYNDDEGFPVTKAMLKPRVREGIQVFWFHTNTSSNKVKFYRENPKASIYFVDTRFFRGVCLAGNVEVLETSEAKEMLWQEGDTMYYKEGVTDPDYCVLKFTAVKGRYYSNFHSEDFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2X0</accession>
    <name>F7K2X0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250148.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00199"/>
    <dbReference type="EnsemblBacteria" id="EGN39232">
        <property type="protein sequence ID" value="EGN39232"/>
        <property type="gene ID" value="HMPREF0994_00199"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.210"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="31927" checksum="A74BA9E7E6FFF94C" modified="2011-09-21" version="1">MAQKKTTRICIFVFCVVLSIITLLPLLLMLLTSVKSISEINAEQFVFFPKHILFSNYAEAMKKGDWTVYFKNTIIVTAITVGISLVINSLAGYAFARIPFKGRDFLFFLAMVGMMIPSQVTMIPVFIQLKEFPLAGGNNILGQGGTGLINTYAGLILPYIAGAFGVFLCRQFYMNIPQALDEAAKIDGCSRIMAYAHIFLPLSKPVLATLAVLKSSQTWNDYLWPLIMISNNSRKTVQVALVSTFVTEVSTNWNLLMAGTAIVMLPLVILFLFTQKYFVEGVVSSGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3C7</accession>
    <name>F7K3C7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250309.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00360"/>
    <dbReference type="EnsemblBacteria" id="EGN33501">
        <property type="protein sequence ID" value="EGN33501"/>
        <property type="gene ID" value="HMPREF0994_00360"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="148" mass="17386" checksum="0BABD71105FCEC8D" modified="2011-09-21" version="1">MKSEKGAEMFVYKLLQVMPDWHSRLVRPFKEKLNGEMSLETYYCLQTLRMRGLATMTELAHELKVPKQQVTKLVDKLCECEFVERVQHAEDRRSVCIRLTPKAVAYLDSYYTKNRAFIESLEEQLTEEDIMRLNQAVGILSDILPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3G9</accession>
    <name>F7K3G9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00402"/>
    <dbReference type="EnsemblBacteria" id="EGN33543">
        <property type="protein sequence ID" value="EGN33543"/>
        <property type="gene ID" value="HMPREF0994_00402"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.440"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="363" mass="41006" checksum="8C1FDAC00E056373" modified="2011-09-21" version="1">MKYTKLGNSDLTVSRICMGCMGFGDAARGQHSWTLDEEHTREIIKRGLELGINFFDTAIAYQSGTSEQFLGRALRNYGKREDFVVATKFLPRTKEDIEAGISGQKYIEKMIDKSLDNLGMDYVDLYIYHMWDYKTPLYEIMDGLNRIVKAGKARYIGISNCYAWQLCMANELAEREGFAKFVSVQGHYNLIFREEEREMVPYCREENIALTPYSALAGGRLSKRPGERSKRLEEDSYAKLKYDASREQDELIIGRVAQLAAERNVSMTEIALAWLLTKATSPVAGATKLHHVEGAARAAELTLGEEEINYLEEAYVPHRLVGVMAQNTAAPKAERTVWPAGEAVLKNISFDGLINQRRGENKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3W2</accession>
    <name>F7K3W2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250490.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00541"/>
    <dbReference type="EnsemblBacteria" id="EGN44729">
        <property type="protein sequence ID" value="EGN44729"/>
        <property type="gene ID" value="HMPREF0994_00541"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="27974" checksum="71EEBE860F43DEB3" modified="2011-09-21" version="1">MAKTIVLSNQKGGVGKTTTANALALIFRERGYKVLAVDLDPQGNLSFSTGADTDGTATIYEVLKEEVKPRFAIQKTGLVDIIPSNILLSSIELEFTGTQREYLLQRALEPLQQVYDYIFIDSPPALGILTVNAFTASDFVLVPMMSDIFSLQGLTQLSETVSRVKNFCNPDLQILGVFLTKHNPKTRFSREVKGALNMIAQDFSIPVLDTFIRESVALREAQSIQQSVLDYAPSCNAVQDYKTLTDELQERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K441</accession>
    <name>F7K441_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250581.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00632"/>
    <dbReference type="EnsemblBacteria" id="EGN44820">
        <property type="protein sequence ID" value="EGN44820"/>
        <property type="gene ID" value="HMPREF0994_00632"/>
    </dbReference>
    <dbReference type="GeneID" id="29726729"/>
    <dbReference type="eggNOG" id="ENOG50326FJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495900_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="549" mass="61531" checksum="3D391262212DF032" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4A4</accession>
    <name>F7K4A4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_00683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250632.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00683"/>
    <dbReference type="EnsemblBacteria" id="EGN44032">
        <property type="protein sequence ID" value="EGN44032"/>
        <property type="gene ID" value="HMPREF0994_00683"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.739"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN44032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="499" mass="57284" checksum="F0724224FC5DA788" modified="2011-09-21" version="1">MENKKLTNEVGAPVSENEHSLTSGPRGPVALQDVWLLEKLAHFDREVIPERRMHAKGWGAYGTFTCTHDISQWTKAKVLQKGATTDLFIRFSTVAGERGAADAERDIRGVAVKFYTEEGNWDLVGNNTPTFFLRDVHNFPDLNRAVKRDPRTGMRSAQNNWDFWTLLPETFHQTTIVMSDRGIPATFRNMHFFGEHTFAFYNQKNERVWCKFHFKTQQGIKNLTNAEAEALIAKDRESHGRDLFMAIEKGDYPRWTMYVQIMTEEQARNHYENPFDITKIWRHAEYPLHEVGVLELNRNPENYFAEVEQAAFTPAHVVPGIGFSPDKFLQGRLFVYGDAQRYRLGVNYNQIPVNRAKVEVHDYHRDGLMRTDGNYGAAPAYSPNSQGEWAAQPDVMEPPLNLEGALYAYDPQDDPTDDCFRAGGDLWRVMEPDKRDLLIENTVENMEGVTENIKYRHAVHCYWADEEYGRRMTAGLGLDMEKVKELAAGNHKTLVQATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4C8</accession>
    <name>F7K4C8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00707"/>
    <dbReference type="EnsemblBacteria" id="EGN44056">
        <property type="protein sequence ID" value="EGN44056"/>
        <property type="gene ID" value="HMPREF0994_00707"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356401" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="383"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN44056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="512" mass="58377" checksum="7D58A013DFD18133" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4W4</accession>
    <name>F7K4W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00893"/>
    <dbReference type="EnsemblBacteria" id="EGN43202">
        <property type="protein sequence ID" value="EGN43202"/>
        <property type="gene ID" value="HMPREF0994_00893"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_7_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="431" mass="48834" checksum="274829160AAB8F26" modified="2011-09-21" version="1">MKELCRPTKQQQLWADCELGVIIHYSRGLLGMDRLEGISPEKAAAPARLQPKKLDTDQWLENAAALGAKYAVFVANQRNCQGISLWQSGSNPRSMRQSPYEQGTFDCVGEFIKSCKKYDILPGLYYQTGFNGHYFNKEQYRMPGTKEHEEYVRIVEEDLEELWTRYGQLFEIWFDGGVVTRKDGGADVAGLLEKYQPQAVCFQGPEEHGQNLRWIGNEDGLAPFDTWSTTDKKVCHFDGSSQDMQIGKGVPGGKYWFPAETDMGNRRPEAAGTGWGWAPGEERLVWTPEELLERYYTSVGRNSNFLLGQCIADDGSFPDTLQFRTLGKYIRRIYERPLNSIRGEGTSFVLTLPENSIVKNISVMEEIAEGEKIRKFRITAITDIGERELIHAGCIGHKRLIAAGNLRAEEIRLEILQSEGKPCIRDFTVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Z4</accession>
    <name>F7K4Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250872.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00923"/>
    <dbReference type="EnsemblBacteria" id="EGN43232">
        <property type="protein sequence ID" value="EGN43232"/>
        <property type="gene ID" value="HMPREF0994_00923"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1009"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102949_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="227" mass="26712" checksum="814AC167EB2B9EE4" modified="2011-09-21" version="1">MKNIYEKYKHIIPFALYFLVYMTWFSWLEQRHIWQYQIIHLAIDDYIPFNEIFVIPYFLWFVYVPGIVLYLAFHNKDDYYRSAIFLCTGMTVFLLVSTFFPNGQRLRPIVMPRDNILTQMVASLYRTDTPTNLWPSIHVYNSLGAHIAIARSQAGKKKWVRITSGILCVSIILATVFIKQHSVFDMLTAFVMAAAMYGVVYHYDVLVYLKQHRTARRAAKTARNEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Z9</accession>
    <name>F7K4Z9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250880.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN43240">
        <property type="protein sequence ID" value="EGN43240"/>
        <property type="gene ID" value="HMPREF0994_00931"/>
    </dbReference>
    <dbReference type="GeneID" id="29724608"/>
    <dbReference type="HOGENOM" id="CLU_1413557_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356412" evidence="1">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="192" mass="20971" checksum="A29CC731BA626E41" modified="2011-09-21" version="1">MKKQVAISSVITVLIIFILAGCAKSQGDETESDTVEISTDSPASLLETVDNGKMEADKEPRTEPSFTEVDISDPNILMSLTAGNVFGDREWIPGLDAYKEVGLEEKIYQMEIDGVEGKEVYLYFIGVPSLSEPSDTMEVKIQIDRTELTFPLNGKQTYQPIVLPDHGTGKTYLTLSSGNGELSNVFVAIGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K554</accession>
    <name>F7K554_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250941.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00992"/>
    <dbReference type="EnsemblBacteria" id="EGN43301">
        <property type="protein sequence ID" value="EGN43301"/>
        <property type="gene ID" value="HMPREF0994_00992"/>
    </dbReference>
    <dbReference type="GeneID" id="29723476"/>
    <dbReference type="eggNOG" id="ENOG502Z976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643472_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="451" mass="50034" checksum="5B2C968D00ADF1CB" modified="2011-09-21" version="1">MEQEMIGLASKMEPGLAAGAYTLKASQDSSIPDSKIEPALFSFRCGADPLRMQQTDVYSVYPPREAFGKFERVLPNIVFTNKTLPWERKVNKADKAPWLALLLFDETEDAAITSLPAEEAFTPAQGRYCPVNYDSSMAGSCMILDAAAGLFGSICPDAGDLALCAHARCVCRDNKVTEKDPPEEWLSVLLSTRYPAAVSGERGIRNICCVVSLEHFGEFLTDPALRAEIAKGEIYKTVRVPVLYSWSFYCSSEEFDFKTVFERLDAGALQLPEIKKDSLPEELLNLMKLGYGPVDHQLRDGSNTVSFYRGPFRAYKEKESGMTPQMNGDAWLRYDPAIGMFDITYSAAYCLGRQLALQNGSYAADLHKWRSEDKAQAGKIRQRYILACRLGLEPEISSCCMELMTKSQKDAVPDGGSNLSGIEGTGLFSELMEKAIKERLERAAKELLKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5G0</accession>
    <name>F7K5G0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251038.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01089"/>
    <dbReference type="EnsemblBacteria" id="EGN42851">
        <property type="protein sequence ID" value="EGN42851"/>
        <property type="gene ID" value="HMPREF0994_01089"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1196"/>
    <dbReference type="eggNOG" id="ENOG5031KJ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145230_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="151" mass="17436" checksum="DC01D955A0ECA124" modified="2011-09-21" version="1">MTGREDGKENDLFFTCSLIEYIARKTKNKRSDTVDCLGRTAIEKIYDLADVYHSDNIETVSDEFIEKYGLKEGTFDNVSAAKYAVPSYWDIGKIYKRLILGISREKRISVIDALFEAYHSFVTDKIEDYNSSFYYDAPQNFLNAFLDGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5G8</accession>
    <name>F7K5G8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251046.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01097"/>
    <dbReference type="EnsemblBacteria" id="EGN42859">
        <property type="protein sequence ID" value="EGN42859"/>
        <property type="gene ID" value="HMPREF0994_01097"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1203"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="431"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="530" mass="61079" checksum="DF4A5C775D505DC6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5L9</accession>
    <name>F7K5L9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42914.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359957.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01152"/>
    <dbReference type="EnsemblBacteria" id="EGN42914">
        <property type="protein sequence ID" value="EGN42914"/>
        <property type="gene ID" value="HMPREF0994_01152"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_21_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42914.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="33316" checksum="42A86660E6C8BE81" modified="2013-09-18" version="2">MEEVVLSVITVCYNAEHKIEKTLCSVLEQIWTKYEYVIVDGASSDRTFEVINKYIEEFKKKGINCRIIREKDEGIYDAMNKGAKLALGTWIIYLNAGDIFYNNYVLLNVSRWFHLKADVLYGDTIEISKSKWRVACGKNVDEITSGMIFCHQSAFIKKKIMIENPYQEQFKICADYNFFLKIFLLGAIYKKIDVIISVFELDGISSQNGFEVRRENVKVLFLNKIITERQKAYRLFRISIEEKIKLLLPSVLFDFKRKAVLRTWFDIGEYETHKKEELKKEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5W1</accession>
    <name>F7K5W1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-sedoheptulose 7-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251189.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01240"/>
    <dbReference type="EnsemblBacteria" id="EGN42487">
        <property type="protein sequence ID" value="EGN42487"/>
        <property type="gene ID" value="HMPREF0994_01240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1356"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080999_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="203" mass="21836" checksum="58152CA8524C9B19" modified="2011-09-21" version="1">MNDLERLTERYPALAGMKEEIAGAFRILKESYENGGKLLVCGNGGSASDSDHIVGELMKGFYKKRPLSEEEKEKYGELAGHLQGALPAISLTGHPALSTAFLNDVDPEMVFAQQVYGYGREGDVLIAITTSGNSVNVLHAVKVAKAKGMKVIGLTGHDGGALKELCEVCLIVPGGTTADIQEYHLPVYHTICAMLEEHFFPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K606</accession>
    <name>F7K606_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251234.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01285"/>
    <dbReference type="EnsemblBacteria" id="EGN42317">
        <property type="protein sequence ID" value="EGN42317"/>
        <property type="gene ID" value="HMPREF0994_01285"/>
    </dbReference>
    <dbReference type="GeneID" id="29724693"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1404"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564616_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="108"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="483" mass="54706" checksum="69DA5CE764B0E74E" modified="2011-09-21" version="1">MGHVFSLSNLIKAYRYLKKNGAAAAFSAVQERILQDGKNDWKYQKPGRETLEAQRKDAIASFEAMAFSEAATSLDTMASSETMVSSETAASSEPAASAEKKGSPVLFSIAVPAFKTNPVYLKELLDSLQEQSYPYWELLLADAGGEDSMEQAVRERKDDRIRYIRLEANEGIAGNTNAAIRRASGRYIGLLDHDDVLTPDALYEMAHALKEKEKRGIHPLFLYSDEDKWDGEDSYYEPHHKLDFNLDLLLSNNYICHFLVMEASLMKRLLLRPGFDGAQDYDLVLRASADVLRDKAEELCVHIPKVLYHWRCHKESTASNPASKTYAYEAGRRALEDFAKNQGWNVSIHDTRHLGFYRMEFLPDVLSQRKDIAAAAGPLPSVKGKLISGIYDTDQQGNTKMRYQGLRRSFSGYMHRAVLLQDVETADIRTMQVSPQWQSALDHALRQIREGADPIQTSIHLCKEMRKEGFRILWDPCRKEGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K625</accession>
    <name>F7K625_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251253.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01304"/>
    <dbReference type="EnsemblBacteria" id="EGN42166">
        <property type="protein sequence ID" value="EGN42166"/>
        <property type="gene ID" value="HMPREF0994_01304"/>
    </dbReference>
    <dbReference type="GeneID" id="29723776"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1425"/>
    <dbReference type="eggNOG" id="ENOG5030TSQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054341_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045723">
        <property type="entry name" value="DUF6077"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19554">
        <property type="entry name" value="DUF6077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="359" mass="40175" checksum="2F2317CBCBC9B5A2" modified="2011-09-21" version="1">MAVKVLITFGVLFAAPFCIGLFPVRYMPGEENKKDPVTVYLAGFLLMLAVFQLLAVPIILMKPWGFPQIVTLYSLLLAVLSAVGLIAGRTVLKKMAEAVTGFFDKKGKFSWETFIYWLIAGGLIVFQIYMAYTHAFFDGDDAYYVAQSVIADQSNVLYRILPYTGLTTTVDVRHALATLPIWEAYLARISGIHPAIIAHSLLPLIFIPVTYLFYFQIGKRLLKKDYRKLAVFMILVSVLQIFGNTSIYTNSTFFLMRTWQGKSMLCNMVLLAVLWCLLSLWDNRGEAKKEKQTGWWIVLCAVNMTAAMATTMGAFLTGLLIAVVGLVIAVRDRRPQVLPKLAASCIPCILYLAVYMVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7K662</accession>
    <name>F7K662_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01342"/>
    <dbReference type="EnsemblBacteria" id="EGN42204">
        <property type="protein sequence ID" value="EGN42204"/>
        <property type="gene ID" value="HMPREF0994_01342"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1852631_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="138" mass="16813" checksum="39812AE7509FD071" modified="2011-09-21" version="1">MGARNNEEIKMWVYTLDKGKKYIFKDIMSVYRYIECKGENNYCSTYKIKDKVHDYSIDFRLVNKLYGYKYNIKPFFLQLVNSYCLYMSEDFKSIFSFLNALSLKCAIDFVGYKIYLKVHKYKNPTKWNQKEYLIKNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6E2</accession>
    <name>F7K6E2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6311 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251396.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01447"/>
    <dbReference type="EnsemblBacteria" id="EGN41921">
        <property type="protein sequence ID" value="EGN41921"/>
        <property type="gene ID" value="HMPREF0994_01447"/>
    </dbReference>
    <dbReference type="GeneID" id="29726874"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023163_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046278">
        <property type="entry name" value="DUF6311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19830">
        <property type="entry name" value="DUF6311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6311" evidence="2">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="554" mass="62873" checksum="3354DF4B34FC9380" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6P1</accession>
    <name>F7K6P1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01551"/>
    <dbReference type="EnsemblBacteria" id="EGN42025">
        <property type="protein sequence ID" value="EGN42025"/>
        <property type="gene ID" value="HMPREF0994_01551"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1693"/>
    <dbReference type="HOGENOM" id="CLU_3344941_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="37" mass="4108" checksum="BCFE4FA9B72148AA" modified="2011-09-21" version="1">MEFVSIGGLVKGITLPDIMHGISQSRNMVLANVFYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6T0</accession>
    <name>F7K6T0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ORF">HMPREF0994_01597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009004413.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01597"/>
    <dbReference type="EnsemblBacteria" id="EGN42071">
        <property type="protein sequence ID" value="EGN42071"/>
        <property type="gene ID" value="HMPREF0994_01597"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1746"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="3"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="427"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="432"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="432"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="516"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN42071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="756" mass="86991" checksum="966487AB151B27B5" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6T2</accession>
    <name>F7K6T2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_01599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009004415.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01599"/>
    <dbReference type="EnsemblBacteria" id="EGN42073">
        <property type="protein sequence ID" value="EGN42073"/>
        <property type="gene ID" value="HMPREF0994_01599"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1748"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="333"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN42073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="576" mass="62916" checksum="F37C6811CDC66859" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7R0</accession>
    <name>F7K7R0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251868.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01955"/>
    <dbReference type="EnsemblBacteria" id="EGN41360">
        <property type="protein sequence ID" value="EGN41360"/>
        <property type="gene ID" value="HMPREF0994_01955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="44162" checksum="80D433D411B2F12F" modified="2011-09-21" version="1">MKLVNQQLIKNTNLKLLYNSVFKNRGISRAALARQTGLSRTAVSALIDELSDRGFLFDSGTGDSSGAGRKPTCLELCAGNYFVAVFGWEESSVHAFLIDICGTTSMQMRLDKAPSDSYAQICRTFLMDQILEQIRPEQLLGLCFVLPAMIDPEKEEVFSTTFSLAGDQGEAGVIPCLRSLFPDYAVAVLNDTACCAYAEKIYTGIREKDYAFIRFSRGIGASLFIQDKLLGQACASYTQFGHFSISPEGPPCPCGSRGCLEVVLSESTLKGRLQAKGTASSLLSMDTVRYEDLGRAALYGDTAAVQVIRDLAGEFSFALSNLICLVHPRLIVLGGNSVSLGSVFLEEIRRSLSETSFARMTENVKLRYSQLDSYACYNGAMKYFFDHHYQFTEPMEGSFFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7V2</accession>
    <name>F7K7V2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpC</name>
        <name evidence="11" type="ORF">HMPREF0994_01998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251911.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01998"/>
    <dbReference type="EnsemblBacteria" id="EGN41403">
        <property type="protein sequence ID" value="EGN41403"/>
        <property type="gene ID" value="HMPREF0994_01998"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2194"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="9">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="134" mass="15162" checksum="BFCBDCBA6E1B5C26" modified="2011-09-21" version="1">MAEDRNFTLKIITPERIFYEGPVSMVEFNTTEGAIGIYKGHIPMTVMIKPGILTITTEEGRREAALHAGFVEILQDKVTVLAEVVEWPEEIDENRAKAALERAEERIKRHESNTDLARAETALERAMARINVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K857</accession>
    <name>F7K857_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252019.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02106"/>
    <dbReference type="EnsemblBacteria" id="EGN41511">
        <property type="protein sequence ID" value="EGN41511"/>
        <property type="gene ID" value="HMPREF0994_02106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="446"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="551" mass="64093" checksum="3CC05094CACD1E61" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K862</accession>
    <name>F7K862_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02111"/>
    <dbReference type="EnsemblBacteria" id="EGN41516">
        <property type="protein sequence ID" value="EGN41516"/>
        <property type="gene ID" value="HMPREF0994_02111"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2314"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="128"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN41516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="38512" checksum="0D5830BC614B43B7" modified="2011-09-21" version="1">MQNISIRKFLRIICAGTALTAAAVLAVLYWLTRDRRIVLCGLILTAVLFMWGAVFLKYFQLKLSLFTDSLCQTLDGMMGGNERPHVDYEAETLLARISHRLERLYNTMQENRHKAEEEKAELQSLVSDISHQTKIPIANLKMLNDTLLTRPVTEEKRREFLEATGSQLDKLDFLIRAMVKTSRLETGLIVLEKKPAAIADTLAAAVNGVLAPMEKKQITLSVDYPEDLTVSHDSRWTSEALFNLLDNAVKYTPADGNIYVTVEVWEFYVKIDVADTGRGIPESAQAIIFKRFYREESMHNVDGIGIGLYLAREIITMQGGYIKVVSEIGKGSTFSVFLPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8A8</accession>
    <name>F7K8A8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="6">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asnS</name>
        <name evidence="8" type="ORF">HMPREF0994_01881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251794.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01881"/>
    <dbReference type="EnsemblBacteria" id="EGN41286">
        <property type="protein sequence ID" value="EGN41286"/>
        <property type="gene ID" value="HMPREF0994_01881"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2061"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="135"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="463" mass="53344" checksum="3E81C0DFFC18F1B4" modified="2011-09-21" version="1">MELTNIKDLFREKEQYKDKKVTVGGWVRSNRDSKNFGFLVVNDGTFFEPLQIVYGSEMENFGDIAKIGVGAAVVVTGKIVETPGAKQPIEMHAEEVLVEGPSPADYPLQKKRHSFEYLRTISHLRPRTNTFQAVFRVRSLAAYAIHKYFQERNFVYVHTPLITGSDCEGAGEMFQVTTLDLENVPKTEEGKVDYSQDFFCKPTNLTVSGQLDAETYAFAFRNVYTFGPTFRAENSNTTRHAAEFWMIEPEMAFADLKDDMMLAEGMLKYVIRYVLDNAPEEMAFFNQFVDKGLIERLEHVLSSEFGHVTYTEAIEILEKHNDEFEYKVHWGSDLQTEHERYLTEKEFKRPVFVTDYPKEIKAFYMKLNEDGKTVAAMDCLVPGIGEIIGGSQREDKLDLLEKRMEEMNLNKEDYEFYLDLRRYGSARHAGFGLGFERCVMYLTGMGNIRDVIPFPRTVKNCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8G1</accession>
    <name>F7K8G1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acylneuraminate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11344"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60073"/>
            <dbReference type="ChEBI" id="CHEBI:68671"/>
            <dbReference type="EC" id="2.7.7.43"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylneuraminate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CMP-NeuNAc synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KdsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.43" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252054.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02141"/>
    <dbReference type="EnsemblBacteria" id="EGN41048">
        <property type="protein sequence ID" value="EGN41048"/>
        <property type="gene ID" value="HMPREF0994_02141"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2342"/>
    <dbReference type="eggNOG" id="COG1083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042930_0_2_9"/>
    <dbReference type="UniPathway" id="UPA00628"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008781">
        <property type="term" value="F:N-acylneuraminate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006054">
        <property type="term" value="P:N-acetylneuraminate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="401" mass="44614" checksum="CEE88A88119B6DF0" modified="2011-09-21" version="1">MNVAFIPVRGGSKSIPLKNIKPICGKPLVYWTVKASCQCKYIDVVYIATDSDKIKEIVEAFKCGDEAETFSKAQIIGRSAESASDTASTEFVMIEFAVNYDFDNIVLVQATSPMLTAADLDGGFELFNSDGTDSVLSVVRQYRFLWDKDENGNVTSSNYDVFHRPRRQEFDGYLMENGAFYISSKADLIKYQNRVSGNIKAYEMCEDSAFEIDEPSDWIIIEALMRKNGLVKEKQTVEEEEIAEERKSIPEIKMFLTDCDGCLTDGGMYYSENGDELKKFNTRDGMGFALLRAKGIITGIITSESVDLNRRRAEKLNLDVLEAGCKDKVAVVKRLCEQYGIGLDNVAYIGDDINDMEVIKMVGYGCAPADSMPQVKAVADYVTKAKGGEGVIREVVSLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8M4</accession>
    <name>F7K8M4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252113.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02212"/>
    <dbReference type="EnsemblBacteria" id="EGN41119">
        <property type="protein sequence ID" value="EGN41119"/>
        <property type="gene ID" value="HMPREF0994_02212"/>
    </dbReference>
    <dbReference type="GeneID" id="29726412"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2416"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023907_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19127">
        <property type="entry name" value="Choline_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363804" evidence="5">
        <location>
            <begin position="31"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="420" mass="45705" checksum="9D8D184F29A14B84" modified="2011-09-21" version="1">MNWKKRIVSLVLAAVIGVGTFLSSGVEAEAAGVIGKGIDVSKYQGAINWSAVAADGYSFAFIKVGSAKSGLDPYFAANMVGANAAGLKTGVYLYSYATTVEAAMAEAQFTLAAIAPFTVNMPVVFDLEDAVHKSMTPEQLAALTVVFCTIIQSAGYYPMVYSSKNWLTQRIGPVPFDVWAAQYADACEYPNPAFWQFTSSGTVNGIQGRVDLNFQFKDYSNIIIPYGFTTRGGKTYFYNNYRMQYGWVDYEGNRYFMNADGTLYNNGWLTDGVNTFYMDTKDGHMLRDLVTIQGKNYYFDVNGFMQKGYVTIAGLTYLFGADGSMQYGWFTDEKGVRYFQEDGSMAMNKTLVLDGKTYVFDASGYGQEVVAPDIDLTGVDPSTWVLDPATGNMIDTATGLPVDPAIAAAVIAQAQAAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8N1</accession>
    <name>F7K8N1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PBP5_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41126.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02219"/>
    <dbReference type="EnsemblBacteria" id="EGN41126">
        <property type="protein sequence ID" value="EGN41126"/>
        <property type="gene ID" value="HMPREF0994_02219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP5_C" evidence="3">
        <location>
            <begin position="353"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41126.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="457" mass="50783" checksum="E661C048F6E1E1F0" modified="2013-09-18" version="2">MQMKYFHSKSFRSKTIRPRFFFTKIYQAMFLSCVLILSPVVLFSVQTIEACAQENDKDGTTSELYALSAVLMDADNGRILLQKNGTEVLPMASTTKIMTCILALEQANPDDYVSVSSYAAGMPKVHLGVRKGDVFRLGDLLYSLMLESHNDSAAIIAEHVGNCLAGGGKRSADNSEEESKEAILRFAGLMNAKAEEIGCADTFFVTPNGLDAILTYQDDSGNEVQRQHSTTASDLARIMSYCIMDSPKKEEFLTITRTPAYSFSDYKLGEDGQWAAGGRQFSCNNHNAFLNMMEGALSGKTGFTGKAGYCYVGALARDGKTFTIALLACGWPNHKSWKWHDAKLLYEYGLSNFEKRNIYEKTDLSPVPVEGGICEDTVLQVQEQDISLLLSEQDEVHMELEVPDSLTAPVEAGKTVGWETYYVNGEVYAQLPITTAEDVLELTYRYCLDRILELFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Q1</accession>
    <name>F7K8Q1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252146.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02245"/>
    <dbReference type="EnsemblBacteria" id="EGN41152">
        <property type="protein sequence ID" value="EGN41152"/>
        <property type="gene ID" value="HMPREF0994_02245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2451"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN41152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="25935" checksum="AB9E2A7353240240" modified="2011-09-21" version="1">MRVLIADDEREMTQALEAILKHEHYSVDIVYDGQAALDYGLAETYDCLVLDIMMPKLNGLQVLERLRENNISTPILLLTAKGQVEDRIEGLNCGADDYLPKPFDVGEFIARVRALTRRNGVFTSHILTVGNISLNRSTFELSRDEMAVRLGNKEFQMMELLMRQQGRFISTEQFMERIWGYESESEINVVWAYISYLRRKLSALGANVKITASRGRGYMLEVEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8R6</accession>
    <name>F7K8R6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252164.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02263"/>
    <dbReference type="EnsemblBacteria" id="EGN41170">
        <property type="protein sequence ID" value="EGN41170"/>
        <property type="gene ID" value="HMPREF0994_02263"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033AD1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658420_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="478" mass="52980" checksum="889BEC847E352571" modified="2011-09-21" version="1">MICPKCQNEIPDESIFCPNCGYQLGESDFTNTISKGKISLNILFSIIGIICAVIIIVILIAVNSTPAAKYNKAEDAFAAGNYERAIKYYTAAGDYEDAQEKLAEATIADHYAKGIEFFGKEEYDEALAQFKNAAGYENSDEMIKKCNYARGNLYLEAGDLLSAAEEFKAAKGYEDSNEKILDIGREYVKNKDYETALTVFGYVKGGKNDEYAQYAQGMISFNNKKYAEASAYFEKAGTLFDAEGLYAESVYNNAKSFMDSQEYTSASKLFIKISDYQDSSEMSNACILLSAKKNMEEGNLNQAKKELGTLPDNFSYNGTNSADLITKLNSISNWIGLCGQWSSTTGLAESNCKARNYYYDGGTWTHDIEKGDYKLDIKCRLNDDGSINLSGNGSIFVFTNWSTIQIGLKYNISKSISFDKKVSASDFGTPLVIDDYTTITLSAKGIELKYKETDNNSVTSFIYTYTTKVTFGTLSNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8T2</accession>
    <name>F7K8T2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252184.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02283"/>
    <dbReference type="EnsemblBacteria" id="EGN41190">
        <property type="protein sequence ID" value="EGN41190"/>
        <property type="gene ID" value="HMPREF0994_02283"/>
    </dbReference>
    <dbReference type="GeneID" id="29724718"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2491"/>
    <dbReference type="eggNOG" id="ENOG5031Z0Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899506_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="33756" checksum="5E09ECAFF5CEB4B2" modified="2011-09-21" version="1">MLFLGTTFFSGSHTLDPPAVHVSPVTEIKLTNGTFDHLYVSKNSEETIESTHNEWNGDTLLSAPFDDSLDAGNSGFSLRNTDVMIVKCREKGSMDWITIHTKDINTIEDFKMLYFYRYARGNTDYEFMLSSTCNGIENSYITREVHSDFNGFFLVNQNNAIGTVYNLDGCDTTRTVSGEAVPLLNSQYAKVVSNGAYNYDTGTVTGVFLKTDTQDCMADLPGGIQLRKDFIDYLTDKTPKILKWDDGRIWMIQIVGTPTDTEEGHKDLRKITFQFAEIGDVRDPKSLYTNGLSPVGVEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Y0</accession>
    <name>F7K8Y0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252127.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02226"/>
    <dbReference type="EnsemblBacteria" id="EGN41133">
        <property type="protein sequence ID" value="EGN41133"/>
        <property type="gene ID" value="HMPREF0994_02226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="158"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="31900" checksum="389ECCE1F38C3268" modified="2011-09-21" version="1">MITLHFCEYNRFNQDYDTIFRPGGSGDYLFLLLKTPMKIYLQEELIITKENACLLFTPQTPQHYQAVKRFCNSYLHFSSDLSPARQYGFPENEIFYPSNPAEIDSFIRSVQMQYFSLAEYRDEYIHCLISQMFISISRDLLHRADRKEDGENLYLLFQNLRLKMLSNCQEEWTIERLCQEVNLEKSQFYVYYHHFFSTTPKTDLLHVRMEKAKSLLSNEALQVQEAARLCGFTSLQHFTRYFRKYCGCSPREYGLSCKKKEEPVPGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K923</accession>
    <name>F7K923_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252262.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02361"/>
    <dbReference type="EnsemblBacteria" id="EGN40760">
        <property type="protein sequence ID" value="EGN40760"/>
        <property type="gene ID" value="HMPREF0994_02361"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2583"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="107"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="277"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="390" mass="43332" checksum="52A5473B60451EF7" modified="2011-09-21" version="1">MSELTFEQMLEESLKTIHAGEVVEGTVIDVKPEEVILNIGYKSDGVLTRNEYTNDPSVDMTAVVKPGDKMEVKVLKVNDGEGQVILSYKRLAADRGNKRIEEAYNNHEVLTAKVTQVLDGGLSVVVEEVRIFIPASLVSDTYEKDLNKYAGQDIEFVISEYNPKRRRYIGDRKQLIVAKKAEMQKELLERIHEGDVVEGTVKNVTDFGAFIDLGGADGLLHISEMSWGRVEHPKKVFKVGDQVTVQIKEINGNKIALSMKFDDANPWKNAAEKYAVGNVVTGKVARMTDFGAFVELEPGIDALLHVSQIAKEHVDKPSDVLKTGEEINAKVVDFNEEDKKISLSIKAMLAPEPKEVKEEEFVQKESDEDVVSVDIDAVIAKQNAEEDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9B0</accession>
    <name>F7K9B0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">leuB</name>
        <name evidence="16" type="ORF">HMPREF0994_02458</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252359.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02458"/>
    <dbReference type="EnsemblBacteria" id="EGN40857">
        <property type="protein sequence ID" value="EGN40857"/>
        <property type="gene ID" value="HMPREF0994_02458"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2694"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_9"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="4"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGN40857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="365" mass="39684" checksum="D7BEA175F4A0E123" modified="2011-09-21" version="1">MELHIGCIPGDGIGPEIVREAKKVLDRVAEKFGHTIQYTEILLGGASIDVHGIPLTQEAIDAAKKSDAVLMGSIGGDANTSPWYKLPPQKRPEAGLLAIRKELGLFANLRPAVLYDELAGACPLKEEISKAGFDMMIMRELTGGLYFGERRTTVENGVRTAVDTLTYNEKEIRRIAVKAFDIAMKRRKKVTSVDKANVLDSSRLWRDVVNEVAKDYPEVELSHMLVDNCAMQLVKNPAQFDVILTENMFGDILSDEASMVTGSIGMLASASLNDTSFGLYEPSHGSAPDIAGKDIANPIATILSASMMLRYSFDLAAEADAVDNAVKQVLRDGFRTVDIMSEDCLKAGGRQVGCQEMGTLLADRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9C7</accession>
    <name>F7K9C7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02479"/>
    <dbReference type="EnsemblBacteria" id="EGN40878">
        <property type="protein sequence ID" value="EGN40878"/>
        <property type="gene ID" value="HMPREF0994_02479"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2718"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140876_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="18598" checksum="7B939C0C45EECA91" modified="2011-09-21" version="1">MVCVNENNREMVTSFIKEHWFTTEMVIRGDIIDMTRAEGIITLDEKENISGLITYMIKDSVCEITSLDSLQENRGTGTALIQEMIRLAEDKGCEKIVLVTTNDNINALRFYQKRGFDMVRIYRNALDKSRSLKPEIPLVGENDIPLKHEIEFELLLNQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9J8</accession>
    <name>F7K9J8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRP/FNR family transcriptional regulator, anaerobic regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252464.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02563"/>
    <dbReference type="EnsemblBacteria" id="EGN40962">
        <property type="protein sequence ID" value="EGN40962"/>
        <property type="gene ID" value="HMPREF0994_02563"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2808"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_7_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="151"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="225" mass="25853" checksum="8E8FEAD487548888" modified="2011-09-21" version="1">MQKEDCGRMAGFFPFWDKLTGEEQKTICRNAASAEYPKGAFIHRASEDCVGVLLVKDGQLRVYMQSEDGRDITLFRIDEGEACVLSASCFMQEITFEILIDAEKDSEVLVIPTAVIRRLSQENIYVENFIYKQAAERFSDVMWTMQQILFMSFDKRLAVFLVDEAAKTGEDTLTMTHDQIARYTGSAREVVSRMLKYFEKENLVELARGRVKLANKKKLQELARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Y1</accession>
    <name>F7K9Y1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252565.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02664"/>
    <dbReference type="EnsemblBacteria" id="EGN40647">
        <property type="protein sequence ID" value="EGN40647"/>
        <property type="gene ID" value="HMPREF0994_02664"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2916"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_29_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="222" mass="24765" checksum="35E331C670A97571" modified="2011-09-21" version="1">MRVVKEAEERRNEILDAADMLFADKGFDNTSTSDILEKVGIARGTLYYHFKSKEDILDALIKRCQEQIINAAGEIAADKGIPVPRRIIGVVRAMSISHDSGKEMKKQMHKPQNALMHQKSQAAVLKGVTPILTEVVQDGIREGLFFTPYPRECMEMLLVYAGTVFDDMMDDTQEVQEQRIRAFIFHAERMLGAESGSLEPDMLQMFTDGPAACHDSCPAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA63</accession>
    <name>F7KA63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02723"/>
    <dbReference type="EnsemblBacteria" id="EGN40706">
        <property type="protein sequence ID" value="EGN40706"/>
        <property type="gene ID" value="HMPREF0994_02723"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2979"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046535_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356493" evidence="4">
        <location>
            <begin position="31"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="44529" checksum="96AE5311B807677C" modified="2011-09-21" version="1">MKKQTKLAGLFISFCLLAVMLAGCGSSSKSASYENSSVAEAPAAYDSGGVYSNYTYDEEAAPEEAAGEEGGSVEVDNSAAHGRKLIKNVDMTVETEDYSTLVAAVQDKVKALNGYIEQFNSYNENSIGRRSANLTLRIPAENLEAFVSRVNEISNVVSRQESIDDVTLQYVDLESHKKMLEEEQKRLLELMEKAETMEDIITIESRLTEVRYQLESMEAQLRTMDNQVNYSTVYLYINEVTRLTPPEEKGTWERIRIGFSENMYHVGHGLKEFCIGFIISLPVLFVFAIIIVVAVIIIKIILRFNRKREEENRKKYGVPYKPTGRPPYGPGPGFVPQGAPRGPMQGAGQNPGADRMPAGNGVLNAEPAGKTNAAEPAVPDAGKKQEEKEPENKEPQKAEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA82</accession>
    <name>F7KA82_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein HMPREF0994_02932</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252833.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02932"/>
    <dbReference type="EnsemblBacteria" id="EGN40541">
        <property type="protein sequence ID" value="EGN40541"/>
        <property type="gene ID" value="HMPREF0994_02932"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3200"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="242" mass="26366" checksum="39D8008FA3C3002A" modified="2011-09-21" version="1">MSGHSKFANIKHKKERNDAAKGKIFTILGREIAVAVKEGGSDPSNNFKLAQVIAKAKANNMPNDTIDRGIKKAAGDMGNVNYEYVTYEGYGPNGIAIIVDALTDNKNRTAANVRSAFTKGNGSIGTPGCVSFMFDKRGQIIIDKEECDMEADDLMMTALDAGAEDFSEEEDSFEILTAPDDLETVQKALEEAGIAMASAEVTMIPQNYVELTDETAIKNLNRTLDLLDAEDDVQAVYHNWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAI2</accession>
    <name>F7KAI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252709.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02808"/>
    <dbReference type="EnsemblBacteria" id="EGN40417">
        <property type="protein sequence ID" value="EGN40417"/>
        <property type="gene ID" value="HMPREF0994_02808"/>
    </dbReference>
    <dbReference type="GeneID" id="29725543"/>
    <dbReference type="HOGENOM" id="CLU_2788572_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="68" mass="8001" checksum="4E0619E75A1E41FE" modified="2011-09-21" version="1">MNELKNINEYGTQSEKPFLLIYTNKDNVINYEWLKTKEELLKVMEEVKGYGCEIHDSTLIASCRVEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAL9</accession>
    <name>F7KAL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_02845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252746.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02845"/>
    <dbReference type="EnsemblBacteria" id="EGN40454">
        <property type="protein sequence ID" value="EGN40454"/>
        <property type="gene ID" value="HMPREF0994_02845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3113"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="364"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="617" mass="68989" checksum="391EAEE3D8585AC1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAV9</accession>
    <name>F7KAV9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">HMPREF0994_02988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252889.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02988"/>
    <dbReference type="EnsemblBacteria" id="EGN40308">
        <property type="protein sequence ID" value="EGN40308"/>
        <property type="gene ID" value="HMPREF0994_02988"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3265"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="155" mass="17966" checksum="62A69E8CB66054CB" modified="2011-09-21" version="1">MAKEAMKLVANNKKVYHDFFVDEKYEAGLVLHGTEVKSLRMGKCSIKEAFIAIDKGEVFINGMHISPYEKGNIFNKDPLRVRKLLMHKSEIMKLTGKVAEKGYTLMPLQVYFKDGKAKMEIGLCRGKKLYDKRQDIAKKDARRESEREFKVKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAY5</accession>
    <name>F7KAY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252915.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03014"/>
    <dbReference type="EnsemblBacteria" id="EGN40334">
        <property type="protein sequence ID" value="EGN40334"/>
        <property type="gene ID" value="HMPREF0994_03014"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3292"/>
    <dbReference type="eggNOG" id="COG1564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="5">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="215" mass="23767" checksum="5B4DD0D6BB10D6A9" modified="2011-09-21" version="1">MAGRCVIIGAGDLSVSEIPLHEGDYVIAADGGFSYCRYLEIEPDLILGDFDSVDERNMEDIMEMRARYPEKVKVLPVEKDDTDMLAAIKEGLNKGFEEFVIYGGQGGRLAHTMANIQCLNYLKEKGAKGYLMDGNGMILVAKNETVRFKKNLEGFLSLFSLGEKAEGVTITNMKYLLDKAVVTNDFPIGVSNEFIGKESSVTVENGTLLIMIDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBH2</accession>
    <name>F7KBH2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="6" type="ORF">HMPREF0994_03206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253107.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03206"/>
    <dbReference type="EnsemblBacteria" id="EGN40036">
        <property type="protein sequence ID" value="EGN40036"/>
        <property type="gene ID" value="HMPREF0994_03206"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3502"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="28548" checksum="3C07F90FBD44E65D" modified="2011-09-21" version="1">MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIFTERNGIHIIDLQKSVGKIDEAYNAVSEIAAQGGTILFVGTKKQAQDAVKAEAERCGMYYVNERWLGGMLTNFKTIRSRIERLKQIETMAEDGTFDVLPKKEVIQIKKEWEKLERNLGGIKNMTRIPDAIFVVDPKKERICVQEAHILGITLIGIGDTNCDPEELDFIIPGNDDAIRAVKLITSKMADAVIEANQGEAVYDEEALAATEATDIEEVAVEAEAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBP8</accession>
    <name>F7KBP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253187.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40116">
        <property type="protein sequence ID" value="EGN40116"/>
        <property type="gene ID" value="HMPREF0994_03286"/>
    </dbReference>
    <dbReference type="GeneID" id="29729020"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3592"/>
    <dbReference type="eggNOG" id="ENOG5030EAN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591686_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="17975" checksum="0CF507543B68347C" modified="2011-09-21" version="1">MKNATKFCIITIVIGMLLAFTIFTLFANGMLTLDTSSPFLNILILFAGAMLVALLTGSLAAKNEPRLREAYNCCGNLAAIGGACLTLAAFLTSLSPDFSGIPFALGIAVCFFFLVLLLGGILCFLHAYFSFRPVSCGSTSAPGQTYTRPGYEEIPLNDEVGRCRRPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBU7</accession>
    <name>F7KBU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253245.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40174">
        <property type="protein sequence ID" value="EGN40174"/>
        <property type="gene ID" value="HMPREF0994_03344"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3656"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="450" mass="47714" checksum="FD905A1E9B944043" modified="2011-09-21" version="1">MKETQNFTEGNILLSLVRFALPVLAALFLQTMYGAVDMLVVGQFAAAADVSAVSTGSWLMQLITSFVVGIAMGTTVLLGRKLGEGKPEEAGKIIGASVVLFLLIGIVITFLMELCAVPVARIMQTPPEAFDATVMYVRICSAGSLFIVAYNVLGSIFRGIGDSRMPLITVAIACVFNIAGDFLLVGVFGLATAGAAIATVCAQALSVVISILIIRKKKLPFSFGRKDIVFDKKRMGSVFRLGLPIAFQDLLVSISFLAITAIVNSLGVIPSAGVGVAEKLCGFIMLVPSAFNQSMSAFVAQNMGAGKAERAKKALFTGVGLSLAVGVFMAWLAFFHGDLLAGLFARDAAVIAAAAEYLKAYAIDCLLVSIMFCMIGYFNGCQKTLFVMIQGIVGAFCVRIPVSLFMSRLKPVSLFKVGLATPCSSIVQIALCLGYFILLSRKKLPPEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC41</accession>
    <name>F7KC41_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase (Penicillin-binding protein 5/6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_03420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03420"/>
    <dbReference type="MEROPS" id="S11.004"/>
    <dbReference type="EnsemblBacteria" id="EGN39927">
        <property type="protein sequence ID" value="EGN39927"/>
        <property type="gene ID" value="HMPREF0994_03420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3740"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="90"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN39927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="347" mass="38260" checksum="009F874A4240DAF8" modified="2011-09-21" version="1">MKTGSNTNKERMRAQRLRKQRRRRRRIRRLCTVLIILMIAGLTVFISGRILLGQENKDIISGYTAASEPAEAESESEEPSLSVDVEKLYSPYCILEQLDTGEILASRQKGTRIYPASLTKIMTAILAIENTPDLDQTIPLPDSLFSSLYVQNASMAGFQPGEEASGRDLLYGILLPSGAECCLAFADNIAGSERDFVGMMNRKADQLGMENTHFCNSTGLHDENHYSTAEDIAVLLRYALNNEEFRKVFTASRYSTSPSALHPDGFTFYSSMFQYMETAQFPGGEILGGKTGYTSEAGLCLASLARIGDTEYILVTAGAAGDHQTKPYHILDAESVYSQIGNHSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC78</accession>
    <name>F7KC78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253358.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03457"/>
    <dbReference type="EnsemblBacteria" id="EGN39530">
        <property type="protein sequence ID" value="EGN39530"/>
        <property type="gene ID" value="HMPREF0994_03457"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3778"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356526" evidence="2">
        <location>
            <begin position="36"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="566" mass="62169" checksum="A643AE73D95721F3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCE0</accession>
    <name>F7KCE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03519"/>
    <dbReference type="EnsemblBacteria" id="EGN39428">
        <property type="protein sequence ID" value="EGN39428"/>
        <property type="gene ID" value="HMPREF0994_03519"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3271745_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="41" mass="4214" checksum="F8F5BCFB8D82B823" modified="2011-09-21" version="1">MSPSLPANASGTAVRVPILPAAGYAGILTGDVLTRINTQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCJ5</accession>
    <name>F7KCJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39490.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360211.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03581"/>
    <dbReference type="EnsemblBacteria" id="EGN39490">
        <property type="protein sequence ID" value="EGN39490"/>
        <property type="gene ID" value="HMPREF0994_03581"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39490.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="263" mass="30351" checksum="16C412CD6C0D78D4" modified="2013-09-18" version="2">MDLKYIDIGINLMGKQFASDRDKIVEESLEKGVGLIITGTDMRSNKDAASYLKAKRPENVWCTCGLHPHNADRWNPDYKRDFTEFIRKNKENIVALGEAGLDYDRMFSTKENQQKCFSDILELAEEMDLPLFLHERDAGRDFIKLMKEHPSVCSRSVVHCFTGSKDMARQYLQLGCYIGITGWICDDRRNHDAVEAVKLIPMERLMIETDAPYLTPRNIKGLSSRNVPWNIAYVAQKIAEIKETDTEEVRRITLQNTKKFFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCK8</accession>
    <name>F7KCK8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03594"/>
    <dbReference type="EnsemblBacteria" id="EGN39503">
        <property type="protein sequence ID" value="EGN39503"/>
        <property type="gene ID" value="HMPREF0994_03594"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3927"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="194" mass="21652" checksum="218ABB551E191472" modified="2011-09-21" version="1">MLQAIQNRRSIRKYKKDEVPVSAIEEVLRAGMLAPSSKNRQPWRFIVTAGREKESFLDAMRFGLEREKMQPLLPESACYLGGAENTLRIMEQAPVHILILNTLGVDLHAAAGPEERIFEICNAQSIGAAVQNMTLTATELGLGSLWICDTYFAYQELCSWAGGDLTAVMALGYPDEEPGPRPRKSLEEAVEWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCV0</accession>
    <name>F7KCV0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="5" type="ORF">HMPREF0994_03679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253580.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03679"/>
    <dbReference type="EnsemblBacteria" id="EGN39051">
        <property type="protein sequence ID" value="EGN39051"/>
        <property type="gene ID" value="HMPREF0994_03679"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4014"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_9"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="264" mass="28511" checksum="126A7D5D53D69F42" modified="2011-09-21" version="1">MKIGFIGCGNMGGAMMHGILDSGKCTPQELMASDALEKALEARKEEMGILAAKDNKETAAFADVLFLAVKPQYYQSVIEEIRDTVSMDQILVTIAPGKTLEWLADQFEKPLKIIRTMPNTPAMVKEGMMGMCPNENVTAEDMETVRDICSGFSKTEIIGEHLMDVVTAVSGSSPAYVFMFIEAMADAAVADGMPRAQAYTFAAQAVLGSAKMVLETGKHPGELKDMVCSPGGTTIEAVRVLEEKGMRSAVFEAMKACVKKSRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDF1</accession>
    <name>F7KDF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family, group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253785.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03884"/>
    <dbReference type="EnsemblBacteria" id="EGN38649">
        <property type="protein sequence ID" value="EGN38649"/>
        <property type="gene ID" value="HMPREF0994_03884"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4227"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="246" mass="27001" checksum="38C608FFA57B70CA" modified="2011-09-21" version="1">MRYEELTIEGRNAVIEAFRSGKTIDRVFILDNCQDGPIMTIKREAKKTDCLIKYVSRERLDQMSETGKHQGVIAYAAAYEYAQVEDILKLAEEKQEPPFLILLDNIEDPHNLGAIIRTANLAGAHGVIIPKNRAVGLTAAVARTSAGALNYTPVAKVTNLVKTMEELKKKGMWFVCADMDGTRMYDLNLTGSIGLVIGNEGEGVGRLVKENCDFIASIPMKGNIDSLNASVAAGVLAYEIVRQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDH5</accession>
    <name>F7KDH5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253816.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03915"/>
    <dbReference type="EnsemblBacteria" id="EGN38680">
        <property type="protein sequence ID" value="EGN38680"/>
        <property type="gene ID" value="HMPREF0994_03915"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="33897" checksum="523508082B8E5C19" modified="2011-09-21" version="1">MGTKVRKTHLTKGKITLLCMTIPSVLFILVFSYFPISGWIYSFFDYRIGYKLSKCEFVGLDNFIYAFGDPYIITVILNTLIISILGLLGLPLAGMIAILLSEVRGKKFKKTVQTAITIPNFISWIIIYSIMFSLFSNDGLLTTLVRGLSGNRDSTVTLLTNPGTAKLFMVLTNIWKTVGYNSIIFFAAVTGIDSQLYDAAAVDGAGRWQKILHITIPGILPTFITLLIISVGAILNNGFEQYYVFVNPMIQKNIEVLDYYVYRIGMLNNDIPASTAVSMIKTFISVVLVFSVNKLSKKTLGQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDI1</accession>
    <name>F7KDI1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BclA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253824.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN38688">
        <property type="protein sequence ID" value="EGN38688"/>
        <property type="gene ID" value="HMPREF0994_03923"/>
    </dbReference>
    <dbReference type="GeneID" id="29729460"/>
    <dbReference type="HOGENOM" id="CLU_1494421_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041415">
        <property type="entry name" value="BclA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18573">
        <property type="entry name" value="BclA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BclA_C" evidence="1">
        <location>
            <begin position="39"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="180" mass="18976" checksum="CEE3DA63FE5D8FBB" modified="2011-09-21" version="1">MYQKQNSCHPCGGCIPNKARLSRPASGKPAGLAAYGGLYNSGTQLVFFTAADVPVQVKLNTPMPLKNVTAVNNSLTVQTAGDYEINYNILLNTSQASTAAAAVRRNGEILTQTRGSQTLAEDDTANLSFDGRLSASVIVPLSSGDVLDLVLLIVRTLPDNLNAIINNNANATLSIKKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDN7</accession>
    <name>F7KDN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253802.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03901"/>
    <dbReference type="EnsemblBacteria" id="EGN38666">
        <property type="protein sequence ID" value="EGN38666"/>
        <property type="gene ID" value="HMPREF0994_03901"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4245"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="36795" checksum="DFDF636944DF2212" modified="2011-09-21" version="1">MQAYLFVHFKEKTTPDGEQVYFGLSRDGFHWEEVNGGNPVLWTYYGDKGVRDFTITRCEENGRFYIFATDLSLSYGMRNQYHGSWEEIGRNGSKCFSVWESDNLTDWTEQRLVKIGDENFGCLWAPDIIYDRENKDYLLHWSSSHSCNDYGRKGIYFCRTKDFHEFSKPELLYRKEDSGIIDSAVYEENGLYYMFVKSEGNPEKIILLKSEQAAGPYERVEAFDRSMEAVESGLYEAPTAVKLEDGRWCLFLDYYGVPGAGQGYVPFVADSLADGRFVRSDASFDFPYGFKHGTILTISMEEYQRIKEHDWSDKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDS1</accession>
    <name>F7KDS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253901.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04000"/>
    <dbReference type="EnsemblBacteria" id="EGN37689">
        <property type="protein sequence ID" value="EGN37689"/>
        <property type="gene ID" value="HMPREF0994_04000"/>
    </dbReference>
    <dbReference type="GeneID" id="29729258"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4357"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022800_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN37689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="675" mass="76591" checksum="63876DBC08253D11" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE79</accession>
    <name>F7KE79_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254059.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04158"/>
    <dbReference type="EnsemblBacteria" id="EGN36951">
        <property type="protein sequence ID" value="EGN36951"/>
        <property type="gene ID" value="HMPREF0994_04158"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4531"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="7">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="6">
        <location>
            <begin position="160"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN36951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="384" mass="40715" checksum="6DC642084CBE1F7D" modified="2011-09-21" version="1">MNTNEKALELHKEWNGKLETVSKTPVKSREDLSLAYTPGVAEPCKVIAGDKEAAYTYTIKANTIAVVSDGSAVLGLGNIGPYAAMPVMEGKAVLFKEFGGVNAVPICLDTQDTEEIIKAVTWMAPGFGGINLEDISAPRCFEIEERLKETLDIPVFHDDQHGTAIVVLAGVINALKVTGKKKEDCRVVVNGAGSAGVAITKLLLNYGFPHIIMCDKSGILSKNSSDLNWMQEKMMEVTNVEGKTGSLADAMKGADIFVGVSAPGIVSAEMVSSMNKDAILFAMANPVPEIMPDIAKAAGAKVVGTGRSDFPNQVNNVVAFPGIFKGALEGRATQITEEMKLAAALAIASLVPDEELNEDNIMPEAFNPKVAEVVAQAVKSHIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEJ9</accession>
    <name>F7KEJ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_04278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254179.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04278"/>
    <dbReference type="EnsemblBacteria" id="EGN36090">
        <property type="protein sequence ID" value="EGN36090"/>
        <property type="gene ID" value="HMPREF0994_04278"/>
    </dbReference>
    <dbReference type="GeneID" id="29725220"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN36090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="608" mass="69519" checksum="44BA01BB3D902223" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF66</accession>
    <name>F7KF66_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254409.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04508"/>
    <dbReference type="EnsemblBacteria" id="EGN35818">
        <property type="protein sequence ID" value="EGN35818"/>
        <property type="gene ID" value="HMPREF0994_04508"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4924"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="501" mass="58289" checksum="AE7EC095E7B6FC0F" modified="2011-09-21" version="1">MKAILIMMDTCNRHMLQVYNPGAKARTPNIDRLAERSLIFDSHFIASAPCMPARRDILTGRVNFLERGWGPIEPYDVTLPRILRKHGIFTHIVTDHSHYMEIGGEGYLQQYNTWDFQRGQETDVWVSSIKDPEEPEPHLGTVFRQYQCNRTRFTDDADRPTPRTFAAAAEWLRQNEGEDNFFLTVEAFDPHEPFDASEEFRAMYPDDFPCFYEWPRYSALNSEETPEALEHLRNQYYATLSMADKWLGKLLDEVDRQELWKDTCIIFTSDHGHMLGEHGVTGKNRYHAWDEMSRIPLLVHMPEDCRAGERVKGLTQNVDLFPTLLEYFGIDRETCGCGSIHGRSWIPLLTGEKEKIRDYAVYGWFGQPVNITDGRYTYFRAAANRKNAPLYAYMAALTTYERYLGCDMPDRVDCGKFLKQCPIPVYRLQMDKETEEPPYLDIGVSRLYDTHKDPGQQNPLTDKELEEKMCLALAKQMELHDAPGEQYERLGLEPYQMKNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFD5</accession>
    <name>F7KFD5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04564"/>
    <dbReference type="EnsemblBacteria" id="EGN35333">
        <property type="protein sequence ID" value="EGN35333"/>
        <property type="gene ID" value="HMPREF0994_04564"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="392"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="601" mass="68475" checksum="2B1B21143438DD2A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFP9</accession>
    <name>F7KFP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254579.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04678"/>
    <dbReference type="EnsemblBacteria" id="EGN34889">
        <property type="protein sequence ID" value="EGN34889"/>
        <property type="gene ID" value="HMPREF0994_04678"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5109"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="313" mass="35598" checksum="B017FC41421D3A0A" modified="2011-09-21" version="1">MLGKKQNVKKVQAGRKVTFRQTYQYHLLMLPGFLVLFIYTIIPFFGNIMAFQNFQPILGFFKSRWVGLDNFRHMLMLPDTARIFRNSFVIAVGKLVFTMVFSILFAILLNEINHIKFKKTIQTICFLPHFLSWVILATIFRNLLDTNGIANQLMMSSGLIKEPLMFLGSNKIFQGVIISTDVWKEFGYGAIIFIAALMGINPELYEAANVDGAGRLQKIWHVTLPGIRVTIVLVATLNIANILNAGFDQIYNLYSPIVYKSGDIIDTYVYRMSFINTQYSLATAIGLLKSVISFIMIVTAHGLAKKFANYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFW0</accession>
    <name>F7KFW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04739"/>
    <dbReference type="EnsemblBacteria" id="EGN34665">
        <property type="protein sequence ID" value="EGN34665"/>
        <property type="gene ID" value="HMPREF0994_04739"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5172"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="413" mass="45928" checksum="5ABE0126C02F7755" modified="2011-09-21" version="1">MNGSKHGKRAGIALLIMLLLFAGGCGKKMDKIPEEPVRTVVTLWHYWDIPACQKAMSRLALEFNNSQDRITVEIKYVPDEDFKKQLALSMAEETMPDIALVDSSDFQFFHHMKKFMDLTDEFPELSSYMPKALAPCESGGRFYGLPFGMNCPALIYNKQMLAEAGCGVPGTWEEFYDTAVRATGESHYGFAMAGIRSEESLYAFLPILWSMGGDVKNINSPAGRASFGMLSSLAGQGALNSQSVSMTLADLMYQFSKGRVAMMFNTGMTVGYIRKNAPEIDFGIAPIPSDGEAVTTVGGEIIGVSTDGHPDEAMEFLHFLAEPERMQSYLDDFGFLAPREDVLERQFPEDEQMQEFVRLFSAARCRDFTPWWPEVSAEITSAMEWAILGEEMEPVLQETDGKITMILERGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG82</accession>
    <name>F7KG82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04868"/>
    <dbReference type="EnsemblBacteria" id="EGN34495">
        <property type="protein sequence ID" value="EGN34495"/>
        <property type="gene ID" value="HMPREF0994_04868"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5311"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="37555" checksum="69A24EF1450984C0" modified="2011-09-21" version="1">MSVTIKDIAKRVGVAPSTVSRVVNGSASISEETKSRILQVMEEMNYHPNSLARNLVNGSTFCIGLIMDARDEGTFSNTFFNRSVYAIEKVTQANGYNLLIANDDSSMGVSAVEKLVLEKKADGLILPSNCVRTGLVEMLLRNECPFVVLGEPAVMKKEACWVDANNEEGAKEAVLHLAGEGFERIAFLLENRNTVFAEKRLAGYLEGIRTAGLEENTDFIRECGQPEQGGSITEHMLEGKKRPDAFLCSNNVIAYHVLQTLKRKNISVPGETGVVTFDNYPFAQYMDPPLTAVDVDTFGIGEQAAFQLIHKIKRADSGNQQTLISTRLLIRESSRRGEVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGA7</accession>
    <name>F7KGA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254764.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04863"/>
    <dbReference type="EnsemblBacteria" id="EGN34490">
        <property type="protein sequence ID" value="EGN34490"/>
        <property type="gene ID" value="HMPREF0994_04863"/>
    </dbReference>
    <dbReference type="GeneID" id="29727788"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5306"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_14_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364012" description="GH18 domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="36"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="42123" checksum="804AAAFF01A05D79" modified="2011-09-21" version="1">MKKKNIAHSLIAAAVLFLAGTGLRTEAAPAKLNKGDTVVGYYTNWSSDKGYNPADIPAGKLTHLNYAFAKIDPAANTIAVANPEKDLKNFEQLRNMKKKYPGLKTLISVGGWDYSTYFSVVAATEESRNQFAAGCVDFILTHGFDGVDLDWEYPVSGGPAGNINSREDKRNFTLLLSAIRNQLNAQTQRDGKKYYLTIAGAANSNYLNKIEAQQVVGLVDHIFVMAYDMHGSWDTYSDFGAPLYNPQERSPQYKNSVHDGVQAYLNAGVPADKLVLGMPFYGYIYEGVGAAQEGRYSTFSSARSISYNNIKGTYLNNPAFSSFYHEGAAVPYLYGNGIFISYENPRSIGTKAAFARNLGLAGVGIWELSHDSAGELLDSARAGLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGF6</accession>
    <name>F7KGF6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254836.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04935"/>
    <dbReference type="EnsemblBacteria" id="EGN34225">
        <property type="protein sequence ID" value="EGN34225"/>
        <property type="gene ID" value="HMPREF0994_04935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="334"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="613" mass="70470" checksum="0F8512CEEEB9022D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGH5</accession>
    <name>F7KGH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-[acyl carrier protein] reductase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254855.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04954"/>
    <dbReference type="EnsemblBacteria" id="EGN34123">
        <property type="protein sequence ID" value="EGN34123"/>
        <property type="gene ID" value="HMPREF0994_04954"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5410"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017569">
        <property type="entry name" value="Enoyl_ACP_red-II_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03151">
        <property type="entry name" value="enACPred_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="32166" checksum="975F947D57B1B650" modified="2011-09-21" version="1">MKTAVTELLGIEYPIIQGGMAWVGEYHLAAAVSEAGGLGIIGAASAPADIVRQQVRDARKLTSRPIGVNVMLLNPNADGVAEVIVEEGVKVVTTGAGSPAKYMDMWKAAGVKVIPVVASVAMAKMMERSGADAVVAEGMESGGHIGSATTMTLVPQVADAVNIPVIAAGGIADGRGFAAAFMLGAQAVQMGTRFVAASESIAHDNYKQKVIKARDIDSEITGMSTGHPIRQIRNKMTREYLKLEKEGASFEELEYLTLGALRKAVMEGDVVNGTLMAGQCAGMVSRVQSCREIIEEIIHDGSALLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH56</accession>
    <name>F7KH56_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006776316.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33225">
        <property type="protein sequence ID" value="EGN33225"/>
        <property type="gene ID" value="HMPREF0994_05192"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5672"/>
    <dbReference type="eggNOG" id="ENOG502Z7XM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074054_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008875">
        <property type="entry name" value="TraX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05857">
        <property type="entry name" value="TraX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="28171" checksum="428089DD78E290F3" modified="2011-09-21" version="1">MDTRFNQTKLKKLQIFNGAQLKYLAFASMLIDHVNNALITPYLNGQGFLLHLSNLFSILGRIAFPLFVFFLVEGFFKTGNRMKYLIMLLIFGVISEVPFDLFTSKTCFSPYWNNIMFTLALCLITIWIIDILKDKISNKYPWYALSILIVAFFGFLSMELNLDYDYHAIVVAYLFYIFYDKPLLGAGLGYISIIKELYSFIGFGMTLTYNGERGKQYKWFNYFFYPVHILILGLLRIYLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH57</accession>
    <name>F7KH57_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MobC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006776318.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33226">
        <property type="protein sequence ID" value="EGN33226"/>
        <property type="gene ID" value="HMPREF0994_05193"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZRU1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2143349_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="16130" checksum="C826A2C495D97E00" modified="2011-09-21" version="1">MAEKDRVRTEQFRFTLLPEENAMLTKNAFEYGLSKSEYLRKLILAESLTGKQWHMDRDQAKQLIYEVNRIGNNVNQIAYNTNAVRFSSNKDWGELQTKYFELMTLFCQFALRENGEEKLWYKKILELMPKDDSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHB2</accession>
    <name>F7KHB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003864557.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05251"/>
    <dbReference type="EnsemblBacteria" id="EGN33284">
        <property type="protein sequence ID" value="EGN33284"/>
        <property type="gene ID" value="HMPREF0994_05251"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XIU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189086_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026990">
        <property type="entry name" value="TnpW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14202">
        <property type="entry name" value="TnpW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="65" mass="7332" checksum="4E64C7E82D045739" modified="2011-09-21" version="1">MTNIVNSTLPTQNNHSEKNKPDGVFVIKQGKTNYKVKVFFDHSSGLTAEDRLKRIIQAEAERESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHC7</accession>
    <name>F7KHC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569211.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05266"/>
    <dbReference type="EnsemblBacteria" id="EGN33299">
        <property type="protein sequence ID" value="EGN33299"/>
        <property type="gene ID" value="HMPREF0994_05266"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5752"/>
    <dbReference type="eggNOG" id="ENOG5032VAM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1977664_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024216">
        <property type="entry name" value="DUF3851"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12962">
        <property type="entry name" value="DUF3851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="13974" checksum="5CCB9BF83C04E690" modified="2011-09-21" version="1">MKQNICELDTMIFFREALEAHEFMLLPVMASAVVECRTADKELKTLNEDGEIGLARLFSIWANMMCAPGAATIVGCRPITMLSEILAQVHAYLTVHPLYDPEGLALYVELHHMMDAILMGDWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHD4</accession>
    <name>F7KHD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255013.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05112"/>
    <dbReference type="EnsemblBacteria" id="EGN33145">
        <property type="protein sequence ID" value="EGN33145"/>
        <property type="gene ID" value="HMPREF0994_05112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037618_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="31710" checksum="998954E24C54A969" modified="2011-09-21" version="1">MASIICTFYSKILAKTTTAQVFLPSFSGKEAFSLSDDERFHTDRKFKTLVLLHGYSESYNAWQRYSQMELFGEDNGIAIICPDGNNGHYTDWETGPQYLTFLNDEFLPAMRAMFPLSDKRQDTFVGGLSMGGYGALKWAFTYPQTFSHLLNFSGGVDIVDRIAYYKERPETAKTMETVYGNLDKVKDSKHDNYWLLKNYDTDQYPLPRLFSSCGTEDGPVFGVHRKLVEMYRELGGDVTVFECEGVHDFHFWNKALERAMYTWLPNEREKYNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI00</accession>
    <name>F7KI00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571045.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05502"/>
    <dbReference type="EnsemblBacteria" id="EGN32943">
        <property type="protein sequence ID" value="EGN32943"/>
        <property type="gene ID" value="HMPREF0994_05502"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6016"/>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031118_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="412"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="471" mass="53550" checksum="22E5F9D6ACE8F818" modified="2011-09-21" version="1">MATTRIMPLHIGKGRTESQAVSDIIDYVANPQKTDNGKLITGYGCDSRTADAEFLLAKRQYIAATGRVRGADDVIAYHVRQSFKPGEITPEEANRLGVEFAMRFTKGNHAFVVCTHIDKSHIHNHIIWSAVNMDCDRKFRNFWGSTRAVRRLSDTICIENGLSIVENPKPHGKSYNKWLGDQAKPSHREQLRVMIDRALEQKPADFDALLKLLSEMGCEVSRRGKAIRLKAPGWKNVARMDDKLGAGYSEAEIRAVLAGEKQHTPRKKSIVQPEPPKVNLLVDIQAKLQAGKGAGYARWAKVFNLKQMAQTVNFLTEHHLLDYAELAEKAAAATAHHNELSAQIKAAEKRMAEIAVLRTHIVNYAKTRETYVAYRKAGYSKKFREEHEEEILLHQAAKNAFDEMGVKKLPKVKDLQAEYAKLLEEKKKTYAEYRRSREEMRELLTAKANVDRLLKMDEEQKKEQEKDHGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI23</accession>
    <name>F7KI23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255332.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05525"/>
    <dbReference type="EnsemblBacteria" id="EGN32966">
        <property type="protein sequence ID" value="EGN32966"/>
        <property type="gene ID" value="HMPREF0994_05525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6038"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="537" mass="62065" checksum="B9A8BE195A2888C3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KID4</accession>
    <name>F7KID4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32324.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05613"/>
    <dbReference type="EnsemblBacteria" id="EGN32324">
        <property type="protein sequence ID" value="EGN32324"/>
        <property type="gene ID" value="HMPREF0994_05613"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32324.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="34649" checksum="3F7876A67DAD42C3" modified="2013-09-18" version="2">MPTTGFSDRVRKVMQTMKIKERPGEKLGHYLIVIIVVAVSLTCLIPFLNTLSLSFSNKSRAAAGEVFLLPKGFNLASYKMLLKDSGFFTAFGVSVLRVIVGGGLNLILTVLMAYPLSKSPKLFRGRNVYMWILIFCMMFSAGLIPLYLTVSRLGLINSFWSLVLPGAVPIYNVILLMNYFRNISPGMEEAAIMDGASHVDILFKIFLPISLPCLATITLFSIVNQWNSFFDGMIYINTPSKVPMMTYIQQLVIPTDTTNITDPRQLENIMQSSNKTLNAAKIMIALLPILVVYPFLQKYFVTGITLGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIH6</accession>
    <name>F7KIH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN32279">
        <property type="protein sequence ID" value="EGN32279"/>
        <property type="gene ID" value="HMPREF0994_05655"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3397107_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="31" mass="3472" checksum="03BCB83C11589D27" modified="2011-09-21" version="1">MTVLRCGNRWGTGYNSGENRVKGEVTLETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIK8</accession>
    <name>F7KIK8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255494.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05687"/>
    <dbReference type="EnsemblBacteria" id="EGN32176">
        <property type="protein sequence ID" value="EGN32176"/>
        <property type="gene ID" value="HMPREF0994_05687"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_29_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="84" mass="9891" checksum="68AF003E1AF7EDC3" modified="2011-09-21" version="1">MAQNLFPLHNYDQNYIEIGYNISYYRKHKKLTQEQLAEKIGISRQHLGAIEAPNVLRQLSLDLLFAIAEALEIEPYKLLLFREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIP0</accession>
    <name>F7KIP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255530.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05723"/>
    <dbReference type="EnsemblBacteria" id="EGN32212">
        <property type="protein sequence ID" value="EGN32212"/>
        <property type="gene ID" value="HMPREF0994_05723"/>
    </dbReference>
    <dbReference type="GeneID" id="29728630"/>
    <dbReference type="eggNOG" id="ENOG5030FS1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071535_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="290" mass="32814" checksum="523F942E2EA4C444" modified="2011-09-21" version="1">MENKFRSTFDKIYAEEELKEKTADFLSKEIRRRKPAGRIFRQRLIGACAVFAAFLFISGLSYFTPNAYVDMDVNPSISLTLNRYGRVLEAAPYNDDGAVILRDVDVRHKSWDQAVERLLDEMILRGYLAPDGLVSVTVQAGGNDREQKMLGEIRESVDTLLDSHHSTASADVYAVTREVRDCAHDYNLSPAKYLAITQLQEVDPGASYEQCAEHSISEIKQLTEEHCGEHHEENGEHHEESGEDAEDENNTEEINDTEEVNDTKAADNGDEKHHSGKKEHHGHEKHEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIR1</accession>
    <name>F7KIR1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569181.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05750"/>
    <dbReference type="EnsemblBacteria" id="EGN32239">
        <property type="protein sequence ID" value="EGN32239"/>
        <property type="gene ID" value="HMPREF0994_05750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6287"/>
    <dbReference type="eggNOG" id="ENOG5032VZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195077_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025468">
        <property type="entry name" value="TTRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041965">
        <property type="entry name" value="TTRAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14203">
        <property type="entry name" value="TTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="68" mass="7602" checksum="D497BC50D4CDDCE3" modified="2011-09-21" version="1">MIRLTVEETNLLSIYNEGGKRALIENVNAALPYMDADMRELAKRTLSKVDALTEAEFAELPIYAADEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ08</accession>
    <name>F7KJ08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255613.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN31465">
        <property type="protein sequence ID" value="EGN31465"/>
        <property type="gene ID" value="HMPREF0994_05837"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2649830_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="76" mass="8657" checksum="350C50AB173F35F8" modified="2011-09-21" version="1">MDKNREYFIIENHSIIKKVRIIKFIGGLYTINIEGTSKYLRVHPSRIYSTYTDASGAAGSGKNKYGTERMKNGQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ53</accession>
    <name>F7KJ53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05885"/>
    <dbReference type="EnsemblBacteria" id="EGN31513">
        <property type="protein sequence ID" value="EGN31513"/>
        <property type="gene ID" value="HMPREF0994_05885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6438"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="298" mass="33708" checksum="BD98B601CC1F039F" modified="2011-09-21" version="1">MKAKYITPVVTVMDKEGNPDMEGCGKVYEHLIQGGVDGILLMGSIGEFFALTMSQKKELIRYAVHKINHRTQLIVGTTSMIVDEIIELSRFAKQEGADAVIILPPYYFPLGEKSLENYFGMLAEALSDQPIYLYNFPDRTGYDLTPEITLRLVRKYENIVGYKDTQAGMDHTRELIKLVKGEFPEFEIYSGFDDNFAHNIMAGGDGCIAGLSNLVPGLCHSWTEAFAREDLEQVSVLQKKIDRLMEIYQVGTPFIPYIKEAMAMKEIIDCACSSKPFPKASEEEKEHIRRILKKTEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ60</accession>
    <name>F7KJ60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05892"/>
    <dbReference type="EnsemblBacteria" id="EGN31520">
        <property type="protein sequence ID" value="EGN31520"/>
        <property type="gene ID" value="HMPREF0994_05892"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6445"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_7_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="330" mass="38061" checksum="88C28DE311A1CA83" modified="2011-09-21" version="1">MKTAKIAPVPSRHPSQGQIEQIKRRFGLFLHFGVNTFGNVEWSDGSIPAQAYCPEQIDAEQWVRAACEAGMNFVVLVTKHHDGFCMWDTDTTKYSVKYSGNPTDVVEKTAQACRKYGIKLGLYYSLWDRNAPQYKEDFDSGYIPYMLEQLTELMDGRYGEIVELWLDGQWDKTRRQWQLDRIYDLVKRLQPGCQIGVNGTVGADNDKASMPDEEYLPAKCRQGDPLCMFPSDFRLWDPHPCRKGDPKIYTFEGKEYYLPFEMTICSREGDSWFYKDTYEKAPLKDAEETAALCRMVFEEENIVVINLPPDKKGKLVEADVTRLMEIADKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJI5</accession>
    <name>F7KJI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255795.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06019"/>
    <dbReference type="EnsemblBacteria" id="EGN31373">
        <property type="protein sequence ID" value="EGN31373"/>
        <property type="gene ID" value="HMPREF0994_06019"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6590"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="27501" checksum="9738E3A3B5B1D766" modified="2011-09-21" version="1">MLEVKHLSYTVTENQETLPIVTDISFTVNDGEMLVITGPNGGGKSTIAKLLMGVIRETEGTILLDGQDITPMSIDERANAGIGFAFQQPPAFKGMTVRRLLNLAAGTKLPEHVSCRLLSSVGLCAKEYLDREVDATLSGGERKRVEIATVMAKDHKVSIFDEPEAGIDLWSFSMLVKQFEQIHREKKESLVLISHQERIIRMADRIMVVRDGRVESCGSKEEIAPQLFLDGAGCACLDREGGNGNETGCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK02</accession>
    <name>F7KK02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255967.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06191"/>
    <dbReference type="EnsemblBacteria" id="EGN30684">
        <property type="protein sequence ID" value="EGN30684"/>
        <property type="gene ID" value="HMPREF0994_06191"/>
    </dbReference>
    <dbReference type="GeneID" id="29724284"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6779"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357513" evidence="1">
        <location>
            <begin position="31"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="473" mass="50737" checksum="3B932897ED9228B9" modified="2011-09-21" version="1">MKKKLLAWFIGVCMVCTCVGCGSGGNTAAAGNTAGSGQTEASQAESTSGGKKTVTFYMWASDAEQEFDKAIVAQYEKENPDIDIEENYIPYAEYLSKINTMAAAGSMPDIFNLPEGNVFEWGAKGALLDLKPLYEAAGVNPSDVSVDSAIFSTDENVWSVGYNVTTLCLYYNKELLEENGIAFPGIDASQPWSWDEFVENAKKITKDSSGSGPDDAAFDPDNITVYGTMMPTDWVKFIPLLHTNDSGILNEDGTALGISSDAGIEVIQSIADLGNKIHCAPSNAMAKGAFSDASAMLMNGQVAMVIDGGWALANYTNEGFDVGVAPIPAFKHPADISWTAGLCMSPNAADNKEAFDFYQYFTNFTNSIQAALDQGVSLGGLPHTLEVFDGGENEAKWVSTYTKVDATQMCESFKNILQADTTVLGDNVRVKNFPVIVDNTIVPALDNVWLGEVSAKEALEALDLSDSIDGYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKI5</accession>
    <name>F7KKI5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">HMPREF0994_06364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256126.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06364"/>
    <dbReference type="EnsemblBacteria" id="EGN47972">
        <property type="protein sequence ID" value="EGN47972"/>
        <property type="gene ID" value="HMPREF0994_06364"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6967"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="14634" checksum="0184FF43E707D9B0" modified="2011-09-21" version="1">MTMSDPIADMLTRIRNANTAKHDTVDVPSSKMKLAIAQILLDEGYIKKYDILDDGAFKTIHITLKYGEDKNHKIITGLKRISKPGLRVYAGKEELPKVLGGLGIAIISSNQGVITDKKARELQVGGEVLAFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKQ7</accession>
    <name>F7KKQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256198.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06436"/>
    <dbReference type="EnsemblBacteria" id="EGN47571">
        <property type="protein sequence ID" value="EGN47571"/>
        <property type="gene ID" value="HMPREF0994_06436"/>
    </dbReference>
    <dbReference type="GeneID" id="29727841"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN47571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="29825" checksum="117519E2B8878F40" modified="2011-09-21" version="1">MSMLCVDKDIKAAVFDVDGTLYDYRNGCVPHSAIDAVARLKEKGYFIIVATGRTMAMLNPQITEELAPDYYILSNGALVSDRNSLIFFSNPFSRKETDFLVDLTNAYGGAMILKYQNENCIYFDYEAGRKLWDVGPGMVEGQTYFDEKHKTHNRKLPIGISIYGDGELKQEIQKFFAVDEFKDAHGIDVMREGVHKMAGLKRLLKGLGLGPENIIAFGDSGNDVEMITQAAIGVAMGNGKKELQQAADYVSPCSWEDGIAEALHTLQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL30</accession>
    <name>F7KL30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_06559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256321.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06559"/>
    <dbReference type="EnsemblBacteria" id="EGN47278">
        <property type="protein sequence ID" value="EGN47278"/>
        <property type="gene ID" value="HMPREF0994_06559"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7181"/>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN47278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="156" mass="17653" checksum="99646896397ADB84" modified="2011-09-21" version="1">MYILFFLLWVIFNGKVTLEIVLFGIVIAGAVYAFCCKFLDYSPRKDWLIMRKFGYIIAYLGVLIWEIVKANAATLKLVASPHIRVQPVIVRFKTDLKTKTARVLLANSITLTPGTITVALQDNEYTVHCLDRRFSEGLSDSVFVRLLHKIEGQVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL51</accession>
    <name>F7KL51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-D-xyloside xylohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256346.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06584"/>
    <dbReference type="EnsemblBacteria" id="EGN47303">
        <property type="protein sequence ID" value="EGN47303"/>
        <property type="gene ID" value="HMPREF0994_06584"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7208"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="682" mass="78207" checksum="EAB7020D101C0D2A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLQ1</accession>
    <name>F7KLQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06780"/>
    <dbReference type="EnsemblBacteria" id="EGN46372">
        <property type="protein sequence ID" value="EGN46372"/>
        <property type="gene ID" value="HMPREF0994_06780"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3356795_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="36" mass="4652" checksum="F196B211C12F34C6" modified="2011-09-21" version="1">MIKNENKNKNKETINRSHYFGGNHFEYYRIWIYTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS28</accession>
    <name>S2KS28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HMPREF0994_07098</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07098"/>
    <dbReference type="EnsemblBacteria" id="EPC05249">
        <property type="protein sequence ID" value="EPC05249"/>
        <property type="gene ID" value="HMPREF0994_07098"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="355"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="461"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EPC05249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="652" mass="74873" checksum="580B3DE4850D3AAB" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVU2</accession>
    <name>S2KVU2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage II sporulation protein P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360250.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07269"/>
    <dbReference type="EnsemblBacteria" id="EPC05120">
        <property type="protein sequence ID" value="EPC05120"/>
        <property type="gene ID" value="HMPREF0994_07269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044446_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010897">
        <property type="entry name" value="Spore_II_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07454">
        <property type="entry name" value="SpoIIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="439" mass="49534" checksum="5E6A7B6547C1BBED" modified="2013-09-18" version="1">MNKKWNGRKIFHKCVLVLLIIAMGDFLFSGRSSVGEGEGEHFSWKEVFAARAQEGVLNVWLPSFAFADKGSASGRGWFEQILGQQVPLFAYAGSQDNENLQTESGSTYEKILLLEGASEYTESEDGDALEVPETSEGKIRLDDNMTQLLQEENQTGQDQDGEQQEVQMPAPDQFGFIKAAGRSQEYNWSYYQDFDALIKEFYAVDATTEANPKRLNLDALLGKTMAITKNPDVPQILIYHTHSQEDFVDSVPGDISTTIMGAGELLAQILREEYGYNVIHHMGMYDVESRDYAYSNSLPAIEQVLAENPTIEVVIDLHRDEVLEGRKLVMDLNGKQTAQFMFFNGLSYTKAHGDIDYLQNPYIDENLAFSFQMQVIANEYYPGLTRRIYLKGYRYNMHLRPRSLLIELGAQTNTVEEIKNACAPIAHILDLELSGKGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>S2L9X8</accession>
    <name>S2L9X8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007037045.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07220"/>
    <dbReference type="EnsemblBacteria" id="EPC05071">
        <property type="protein sequence ID" value="EPC05071"/>
        <property type="gene ID" value="HMPREF0994_07220"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012396_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="579"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="689" mass="75796" checksum="50F0910A6F470BF0" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAD5</accession>
    <name>S2LAD5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_38 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07148"/>
    <dbReference type="EnsemblBacteria" id="EPC05201">
        <property type="protein sequence ID" value="EPC05201"/>
        <property type="gene ID" value="HMPREF0994_07148"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046274_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_38" evidence="1">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="28127" checksum="8F6B3E337DB440D6" modified="2013-09-18" version="1">MSKFLSYEDRLIISQRIQENASFGAIAKELGKDRTTIAKEIRKYSYDKKSGRPGYPYNPCKYRNSCKAKKICGANGCTHQSAYKCSLCSECTFHCPDFEEDICSVKRKPPYVCNGCRALPRCTLLKRIYDPADAHEMAHKTISESRTGILSNESDIARINKLITPLVKNGQSLHQIYTEHVDELMCSEKTLYNYVDAQLFEIRNIDLPRKVKYRPRYKQPEFKVDRGCRLGRSYSDFQKFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAE6</accession>
    <name>S2LAE6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360065.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07158"/>
    <dbReference type="EnsemblBacteria" id="EPC05211">
        <property type="protein sequence ID" value="EPC05211"/>
        <property type="gene ID" value="HMPREF0994_07158"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCDT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130334_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004498670" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="153" mass="16587" checksum="7470E49FE684E239" modified="2013-09-18" version="1">MKKIFLSLILILIGVSTLSGCTKDEILNHYNNVVQSAGSIELTGKLSLQGKKEKGIDDYTGSYQADYENFSDTEYLFGGTSIKREAGKDISVTCTLEVLSGTAKVFWISGADEAVTLLETTGTYSDTITLPDGGNYIGIECEDFTGKIEMNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJN7</accession>
    <name>S2LJN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360073.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07164"/>
    <dbReference type="EnsemblBacteria" id="EPC05168">
        <property type="protein sequence ID" value="EPC05168"/>
        <property type="gene ID" value="HMPREF0994_07164"/>
    </dbReference>
    <dbReference type="GeneID" id="29727194"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_17_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004498990" evidence="1">
        <location>
            <begin position="30"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="404" mass="44831" checksum="411504A7AF478080" modified="2013-09-18" version="1">MRKKIISAALAFMLAAVSLGGCGQEGKEAADQSVITIWHDKEDAVVQVLQKQLDELAPEVTVKLERKSDLTEALKMVGNDPKAAPDMYFFAHDKIGVYAEMGILSPVTDFIPMEELEPYMDMTIKAATYQDVVYQLPVYYETLLFMYNKRYMKEEEVPQTTEELYFYMEENTKGGHYGFVEQHSTAYYSAGWIHGFGGYIMNDQGEPGLDLPQTQKALEYHKKFVELMPGESEYATVNTLFSEGKAHATIAGPWLVPTVRQSGMDLGIAPMPVVDETGMPIAPYSGVQGIQVLKIAGENKKEAVELVLRKLMDPQLQVDLAKASGCAPASEACYEMEEILSDDVVMAMKQTAENAVPMPNRPEMDVMWTVAGNLLADINMSGRGVEESCVKAQKEALRLIGQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2W9</accession>
    <name>F7K2W9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250147.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00198"/>
    <dbReference type="EnsemblBacteria" id="EGN39231">
        <property type="protein sequence ID" value="EGN39231"/>
        <property type="gene ID" value="HMPREF0994_00198"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.209"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="454" mass="51301" checksum="294B86900C910EC4" modified="2011-09-21" version="1">MELKDKCPNIILINCDDLGYGDVGCYGSGVNRTPGIDYLAQNGMRCTSFYMASPVCSPSRGAMMTGCYPPRIGFESFEGEWVLFPGQGVGLNSDEVTIAQILQRAGYRTKLVGKWHCGDQEEFLPTNHGFDEYYGLPYSNDMGRQVFKEDFPPLPLLSGTGIVELQPDQRSITERYVEQCRTFIRENKNNKFFLYLAHMHVHLPLYAGEEFVKKSINGDFGACVEAIDWSVRVLLHELRSLGLEEDTLVIFTSDNGGRGDHGGSNAPLKGNKGTTWEGGQRVPCIFYWPGHIAPGQECRELICSLDFYRTLAELGHGTMPADRKNDSLDIRRVILEGGKTPRDTFFYYIMGNLEAVRDKEWKLHVAKDGKPVRLLYHISEDPGEQENVYESHPEIVKHLEHSLEECRYKLGDTLAGIKGTQIRPIGRVENPHPLAEYDINHPYVVMMYDREEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2X7</accession>
    <name>F7K2X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250155.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00206"/>
    <dbReference type="EnsemblBacteria" id="EGN39239">
        <property type="protein sequence ID" value="EGN39239"/>
        <property type="gene ID" value="HMPREF0994_00206"/>
    </dbReference>
    <dbReference type="GeneID" id="29723661"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592463_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="167" mass="19892" checksum="23F4A71C30975DDC" modified="2011-09-21" version="1">MIYRDLSILWCLINILFIFSQLYESRFPGKKTFFLNLICMGGLIILNMVLVLKMGVIWMGKYFILTCTIPSFFYFFYTSKDRNGRFFFTFCLADIMGFWIMAVSNLISYAFGENFLLMFLLRIFMFLLLEYFVVRYVKKPYHLILQFVKKGWGGFAFASGLFYLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Z5</accession>
    <name>F7K2Z5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250173.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00224"/>
    <dbReference type="EnsemblBacteria" id="EGN37863">
        <property type="protein sequence ID" value="EGN37863"/>
        <property type="gene ID" value="HMPREF0994_00224"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.244"/>
    <dbReference type="eggNOG" id="ENOG502ZCEZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330429_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032358">
        <property type="entry name" value="DUF4867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16161">
        <property type="entry name" value="DUF4867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="206" mass="22572" checksum="810079C029A653E5" modified="2011-09-21" version="1">MEIKKVTDAAFRKYGKVVKNVDFTALVEELEKTPCTAEVVYEPSVPELEALPVYKELQDVTYGEMPIQIGFCNGNNYKLNALEYHRTSEIDVAASDLILLLGWQADVEEDYTYDTSKVEAFLLPKGVAVELYATTLHYAPCNSGEGGFRCAIVLPDGTNLPTDENHFAGGEDALITAKNKWLIGHAEGGLPEGCHIGLKGENISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K302</accession>
    <name>F7K302_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250180.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00231"/>
    <dbReference type="EnsemblBacteria" id="EGN37870">
        <property type="protein sequence ID" value="EGN37870"/>
        <property type="gene ID" value="HMPREF0994_00231"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.251"/>
    <dbReference type="eggNOG" id="COG4905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055257_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN37870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="35552" checksum="CD6F06CEB3C323A5" modified="2011-09-21" version="1">MYHYTLSQWIFFFYFYCFFGWCFESTYVSICQKKLVNRGFIRGPFLPLYGSGAIMMLLVSSPMKGNLVGIFIAGCLGATVLEYVTGVIMEALFKVRYWDYSHKKFNFRGQICLESSLCWGLLTILMTQFIHKPVESLAMMIPPRVLVLAVAVISVLFIADFVTSFQAAMDLRDILIKAEQARQELERLQKRLDVIIAVANNDREIKREKREERMEELASAIEDTFLQLRDAIPGSELLREKMEEIVELRDKFIGSRRVGEENQQSFIHSFFKRNLLKGNPTMTSHKFYDTLEELKKSASEYRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K308</accession>
    <name>F7K308_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250186.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00237"/>
    <dbReference type="EnsemblBacteria" id="EGN37876">
        <property type="protein sequence ID" value="EGN37876"/>
        <property type="gene ID" value="HMPREF0994_00237"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.257"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023775_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="564" mass="64379" checksum="3C869DDD1FAB95AC" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K342</accession>
    <name>F7K342_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250220.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00271"/>
    <dbReference type="EnsemblBacteria" id="EGN37910">
        <property type="protein sequence ID" value="EGN37910"/>
        <property type="gene ID" value="HMPREF0994_00271"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.294"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="111" mass="12989" checksum="D20C46B8BEB1DDB0" modified="2011-09-21" version="1">MKKTEQAIQRCVTISTVQKILGGKWKIEILYYIGRQNVHRFGELRRHIGDITESSLTKQLRELEADGFINRHDFKEVPPRVEYTLTELGKSFMSVLDVIKNWGDLNLKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K393</accession>
    <name>F7K393_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250271.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00322"/>
    <dbReference type="EnsemblBacteria" id="EGN33463">
        <property type="protein sequence ID" value="EGN33463"/>
        <property type="gene ID" value="HMPREF0994_00322"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.346"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="30920" checksum="84712C93E2D65A03" modified="2011-09-21" version="1">MSQRNFISKEELSMMRRYLFYTFAIAWGTEFLLIMLYRFNLLSENITLFLYFTAIGFGAGMAPAYAAFIVQRKQTGIKLKAFCKQVFHTSNMRRSIIFLLLFAAIQFAACIVQESYLGNPWYLFILFIPMMIWGGGLEEIGWRGVFQPLLEKRFSFLAAAFIEGVIWGVWHLPLWFIPNSTQGDMNFIAFTLYCIILGLTLAAAYRLTKCIWVTILIHAWGNTVLGGMYTLTSLNNSPSVKTLVVYALQIAAIMLILLIDKKRRKFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3A4</accession>
    <name>F7K3A4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250286.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00337"/>
    <dbReference type="EnsemblBacteria" id="EGN33478">
        <property type="protein sequence ID" value="EGN33478"/>
        <property type="gene ID" value="HMPREF0994_00337"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.361"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="14870" checksum="EDE1DD9BE385CBA5" modified="2011-09-21" version="1">MKQMKKLPDAEFDIMKVVWANEPPVTTNIIMEQLGTEKSWKAQTVISLMLRLAERGFLSTDKRGKERIYYPLISKDEYLKFETSNFMKQYHDNSFLDLVNTLYEDKALTDKDIDELLQWAKKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3G2</accession>
    <name>F7K3G2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250344.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00395"/>
    <dbReference type="EnsemblBacteria" id="EGN33536">
        <property type="protein sequence ID" value="EGN33536"/>
        <property type="gene ID" value="HMPREF0994_00395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.429"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="196" mass="22458" checksum="B67A7151BE8854D7" modified="2011-09-21" version="1">MGKQLIISVGREFGSGGHVIAEELARRFGLVLYDNNLLEQIAEEKEIPHDGLKKYDEKPKSRLFSRTVRGYSNSVQENLANMQFDYLKKKAADGESFVVVGRCSETILKGTQGLVTVFVLGDPDVKAERIQKVYGVSEEEARRMMKREDWNRKSYHNYYCKGKWGDSRNYDFSINSSKLGIEKTVDILETCIRARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3G8</accession>
    <name>F7K3G8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00401"/>
    <dbReference type="EnsemblBacteria" id="EGN33542">
        <property type="protein sequence ID" value="EGN33542"/>
        <property type="gene ID" value="HMPREF0994_00401"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1903989_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="14980" checksum="FF03EC0D81CB33F9" modified="2011-09-21" version="1">MLLVCGAGKNENQTVSSIQGRQNNLTETETTGQTDDMVQTAKVIIVYFSWSENTRSIANEIRSQTGADIFELVPATPYSDDYNTVLDESLVEQNNQAILERIRTIEDFGSYDVVYVGFCKMEYGFNCVSCMWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3I1</accession>
    <name>F7K3I1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250359.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00410"/>
    <dbReference type="EnsemblBacteria" id="EGN31925">
        <property type="protein sequence ID" value="EGN31925"/>
        <property type="gene ID" value="HMPREF0994_00410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.450"/>
    <dbReference type="eggNOG" id="COG1453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="376" mass="42615" checksum="2B6DB85248F28760" modified="2011-09-21" version="1">MITKTFQNLRLSALGMGAMRLPVVDGNDAQIDEAEAARMVSYAMEHGINYYDTAWGYHDGNSETAMGKILAAYPRDSYFLATKFPGYDLSNMDKVEEIFEKQLEKCGVEYFDFYLFHNVCEMNVDAYLDEKYGILDYLLKQKEKGRIRHLGFSAHGSREVMERFLDSYGSYMEFCQIQLNYLDWDFQDAKGKVELLNSRHIPIWVMEPLRGGKLASLPEEQEVKLNQLRGEKTPAWAFRFLQTVPGVTVVLSGMSDFEQMKENISTFEEDKPLDKKEWEALLGIAGEMVKKIALPCTGCHYCVSHCPKQLDIPALLELYNEHSFTGGGFIAPMALMAVPEDKHPDACIGCRSCEAVCPQQIKISEAMADFASRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3I3</accession>
    <name>F7K3I3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250361.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00412"/>
    <dbReference type="EnsemblBacteria" id="EGN31927">
        <property type="protein sequence ID" value="EGN31927"/>
        <property type="gene ID" value="HMPREF0994_00412"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.452"/>
    <dbReference type="eggNOG" id="ENOG50305PD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132548_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="140" mass="15508" checksum="323259E4E6AB5C44" modified="2011-09-21" version="1">MEEKLRILKMVEEGKLTAEQAVELLKALEGTAPEQETMDSAESFYEGTHAVPENIPYENKMLRIIVDSSAGDKVNIQLPVKIIRQMLMVTGKLPIKTEELEGIDLEELTSSILECIDNETLGNIIEVSSSDGTTVRIFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3J7</accession>
    <name>F7K3J7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250375.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00426"/>
    <dbReference type="EnsemblBacteria" id="EGN31941">
        <property type="protein sequence ID" value="EGN31941"/>
        <property type="gene ID" value="HMPREF0994_00426"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.466"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="27301" checksum="665E16790B0FD75F" modified="2011-09-21" version="1">MYQISNFMDNDDINMLANAGPFTVVEYERDLSVMPSSAAAAYFCSKMNVRKRQVVCDLSKANVTVQAGAMQWMLGNVNATTGIKGVGDLFGKAVRGKVTGESAIKPEYTGDGILVLEPTYKHLILMEAADWGGSVVLDDGLFLACDSKLQHKAVMRSNLSSAVAGGEGLFNLSLNGSGVFCLEADCPKEELVEITLQNDVLKVDGNMAIAWSGSLQFTVERSGKSLIGSAASGEGLVNVYRGTGKVLMAPVSKMPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3N6</accession>
    <name>F7K3N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250414.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00465"/>
    <dbReference type="EnsemblBacteria" id="EGN48183">
        <property type="protein sequence ID" value="EGN48183"/>
        <property type="gene ID" value="HMPREF0994_00465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.512"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010964_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="300"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="748"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN48183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="848" mass="93392" checksum="C5F7386DB4016583" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Y9</accession>
    <name>F7K3Y9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250517.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00568"/>
    <dbReference type="EnsemblBacteria" id="EGN44756">
        <property type="protein sequence ID" value="EGN44756"/>
        <property type="gene ID" value="HMPREF0994_00568"/>
    </dbReference>
    <dbReference type="GeneID" id="29724881"/>
    <dbReference type="HOGENOM" id="CLU_2479362_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="10495" checksum="F9E208D3600E5EC5" modified="2011-09-21" version="1">MKKIRKILACGHGDLNKETDFVDLISFKINVIIKRLIELENIVKRIYKQKIHINDHMKMLKNVKCYKNSEIYLKMFVENNKKYFCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Z2</accession>
    <name>F7K3Z2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FlhB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250520.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00571"/>
    <dbReference type="EnsemblBacteria" id="EGN44759">
        <property type="protein sequence ID" value="EGN44759"/>
        <property type="gene ID" value="HMPREF0994_00571"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.622"/>
    <dbReference type="eggNOG" id="COG2257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="12625" checksum="04ECDBE86552A96A" modified="2011-09-21" version="1">MSEFRETLNKKAVALTYDEDKQNAPVIVASGMGYMAEKIVEIASENGVPVYEDDSLATVLTQLELGSEIPEELYQAVVDIYAYFLHFTLNGEEKKTEAAKPEAVSLEEEMQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K485</accession>
    <name>F7K485_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250626.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00677"/>
    <dbReference type="EnsemblBacteria" id="EGN44865">
        <property type="protein sequence ID" value="EGN44865"/>
        <property type="gene ID" value="HMPREF0994_00677"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.733"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="30898" checksum="D4BB790282C7DB3E" modified="2011-09-21" version="1">MDKKSPEKRSALHILTGAGRYLVMAFVLFISVYPILWVFLSSFKKNPGGLALPTEWVFDGYITIFTKLSIQTYFGNSIFITVISTVISVLVVAMSAYVSARMEFKLKGLVTLMFTTTLFIPSISISFPIYRLLGDLGLKDTRGGLIFIYSGLGIAVTFFIIRSYFLTIPREMEEAARIDGCGYCASFFRIIVPIAKPGLSTAAIMVFLNNWNEFYFASILLKSKGKMTIPALLGQFTTAYSKNLNGMFSAIIVSVVPTILIFCLLSETFVKSLTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4H6</accession>
    <name>F7K4H6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ORF">HMPREF0994_00749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250698.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00749"/>
    <dbReference type="EnsemblBacteria" id="EGN44098">
        <property type="protein sequence ID" value="EGN44098"/>
        <property type="gene ID" value="HMPREF0994_00749"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.815"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="118" mass="13359" checksum="AA56347FDB2A8CBA" modified="2011-09-21" version="1">MARIKGGMNARRKHNKVLKLAKGYRGARSKQYRVAKQSVMRALTSSYAGRKERKRQFRQLWIARINAAARMNGLSYSKFMYGLKLAGIDMNRKMLAEMAVNDAEGFTTLAEVAKSKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4U1</accession>
    <name>F7K4U1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250819.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00870"/>
    <dbReference type="EnsemblBacteria" id="EGN43179">
        <property type="protein sequence ID" value="EGN43179"/>
        <property type="gene ID" value="HMPREF0994_00870"/>
    </dbReference>
    <dbReference type="GeneID" id="29725506"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862729_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027365">
        <property type="entry name" value="GNAT_acetyltra_YdfB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31143">
        <property type="entry name" value="PTHR31143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12746">
        <property type="entry name" value="GNAT_acetyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="184"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="322" mass="37213" checksum="7D26DAA082580743" modified="2011-09-21" version="1">MPCVWQFTFIFGPQAGNCLFNEIKSCNKEKKCGSRFKRRGMERLAYLQREGMNVIKIDKGNISLAKKLALESSCPSFTSILAGIAKGDLWIDDRENPTLALVYSAPVGGYRIMGEIKNKNKLGEFTRFLEEELFLQLKEAKIDEFEFAAESNEVEKMMLMHFRGYKIIEDKELAFIRKPDQERPVVSEISGYDFLEINEECLQNNYQNKDYIVTRIIEAWGTIEKYQNYGIGFIAVEGDRIAGMILGTANYENILPIDIETLKDHRKKGIATELTRRFLAYCYDNKLTAYWNCIISNVESRNIAEKAGFQFIGSKDYYYFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K502</accession>
    <name>F7K502_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250886.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00937"/>
    <dbReference type="EnsemblBacteria" id="EGN43246">
        <property type="protein sequence ID" value="EGN43246"/>
        <property type="gene ID" value="HMPREF0994_00937"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1024"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044694_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="333" mass="37885" checksum="D7F21161337FC9D7" modified="2011-09-21" version="1">MQLLLEDIKNRQFRQVYLLYGQEAYLKNQYRDKLKEALVQDGDTMNFTVFKGKNSNPGEIIDLAETMPFLAERRVILIEDSGFFKKGGEQLADYLKEPASTVCILFSESEVDKRNKLFKAVKDNGCAVEFATQDETTLKRWVLGRIKKENKVISSASLDFFLQKTGSDMENISREMEKLFCYTLKKDTITEEDIEAVCTHQVTSQIFDMVESIAMGRQQLALKLYYDLLALKEPPMRILFLIGRQFNLLLQVKELKAKGCDNRKIGEKTGLHSFIAGKYVSQAARFKKEELREALEACVSTDEAVKSGRLNDTMGVELLIVRYSSGGRASGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K582</accession>
    <name>F7K582_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250876.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00927"/>
    <dbReference type="EnsemblBacteria" id="EGN43236">
        <property type="protein sequence ID" value="EGN43236"/>
        <property type="gene ID" value="HMPREF0994_00927"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1014"/>
    <dbReference type="eggNOG" id="ENOG502Z7TB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060123_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010394">
        <property type="entry name" value="5-nucleotidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367">
        <property type="entry name" value="PTHR31367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06189">
        <property type="entry name" value="5-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="316" mass="34992" checksum="7269555A4F1AD2A0" modified="2011-09-21" version="1">MAYELDNRLVIGISTRALFDLSLENEIFEKEGVESYRKYQTEHEGDILRPGPGFPLVKALLAINALPGQEGRVEVIIMSRNSADTSLRVFRSIEHYGLDITRAVLAGGASLAPYLEAFRTDLFLSAYEDDVQRAVDSGIAAGIICDGGREYAQEENIRQIRIAFDGDAVLFTDESERIFQEQGLAAFEENERLKADSPLEEGPFARFLKTIAALQQEFSPEQAPIRTALVTARSAPAHERVVRTLRAWNIRIDEAFFLGGISKKEILAAFGAHIFFDDQAAHTGNASAAVPSARVPSPERKGRDDRKKNPGRQNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5C5</accession>
    <name>F7K5C5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251003.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01054"/>
    <dbReference type="EnsemblBacteria" id="EGN43027">
        <property type="protein sequence ID" value="EGN43027"/>
        <property type="gene ID" value="HMPREF0994_01054"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1154"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049285_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="31"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="316" mass="35670" checksum="017B2720EB2C24FC" modified="2011-09-21" version="1">MKREFEEEYVEVNGIAHFLLHYPKAPDAPVLLYLHGGPGSMESLFAYVLDKAWGDMFTQVHWDQRGAGKTLLRNKKLGMPETIEQMLDDLHGIIAYLQRKYQIEKLVLLGHSWGSVLGSLYALRHPENVLSYIGTGQVISMMENERTAFQEVWKMAEKAGNRKHLLALGNLGDYPPDDPELLLKKLPKLRKIQAAYDNGPGSGSGQGELLKLLRRSPSFRWNDLIGLIRVMKVNHPLHLQLLSFALTDYPSHYQTPVHYILGETDTIAPTSLGKAYFDTIDAPRKTITVIPGAGHNPMYERPDEFTAALRAVRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5H4</accession>
    <name>F7K5H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01103"/>
    <dbReference type="EnsemblBacteria" id="EGN42865">
        <property type="protein sequence ID" value="EGN42865"/>
        <property type="gene ID" value="HMPREF0994_01103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103318_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="175" mass="19914" checksum="5FAFC29CD2DD72C4" modified="2011-09-21" version="1">MEPNKKLPLFIVSGASGVGKTTMCEILFRRETKYIVMESDILWKEEFNTPEDNYRKFRELWMTMCANISQSGLPVVLCGCGIPEQFEVCEARKYFTDLHYLALVCDTEALETRMRKGRGIADEGWIQSSVSFNEWLQKNAQNTSPAITLINTTNLTPEETAGKAEEWITGILTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5H5</accession>
    <name>F7K5H5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42866.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359953.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01104"/>
    <dbReference type="EnsemblBacteria" id="EGN42866">
        <property type="protein sequence ID" value="EGN42866"/>
        <property type="gene ID" value="HMPREF0994_01104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S59" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="157"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42866.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="30182" checksum="1B4629F4BFEF5F85" modified="2013-09-18" version="2">MNHIRYVEYNARHDGSFVFDVPDGHDCWLLLITHTPAFFRVDGSLREYPAKSAVLFTPRSPIYYCASGSRYENDWMRFDSDEDFVSSLPVQGVPFPLPDAEYCHNLIQLLTWKNSFPGRNNERVVEQLLQLLFSELQEASQSSADSFSQSPHYHDLMNLRKAVYNSPQLPWNVSGMAQQLYLSEGYLQVIYKNTFGISCMEDCIKARIRLAEDQLQYTTKTIASISEFCGYHNVEHFCRQFKRSTGKSPRAFREKGKSRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K679</accession>
    <name>F7K679_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251314.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01365"/>
    <dbReference type="EnsemblBacteria" id="EGN42227">
        <property type="protein sequence ID" value="EGN42227"/>
        <property type="gene ID" value="HMPREF0994_01365"/>
    </dbReference>
    <dbReference type="GeneID" id="29724760"/>
    <dbReference type="eggNOG" id="COG3774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073547_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="29249" checksum="AFFC4AA2C9E435B6" modified="2011-09-21" version="1">MSEYIPKIIHYGWFGGKKKSRFILNCISSWKKHLPDYEIIEWNETNFDICAHPFACGAYKAGKYAFVSDYVRVYTIYHYGGIYFDTDIEVKKDFTDKLLDAKFVIAFELPQSLMTGFFAAQKGNPVVKEILAYYDSISFYKEDGKMRLTPNPVIFANEASKFGLVFNGRYQEIGDMMKIYPNEVFGGYNVYDMIYTITDNTLLVHHYTASWRTIKEEIPVKAKKLFLKILGIRNYRIARKIKHMIKKDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6H7</accession>
    <name>F7K6H7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="5" type="ORF">HMPREF0994_01485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251434.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01485"/>
    <dbReference type="EnsemblBacteria" id="EGN41959">
        <property type="protein sequence ID" value="EGN41959"/>
        <property type="gene ID" value="HMPREF0994_01485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1621"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_9"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="557" mass="63071" checksum="C6781D1E7746F8CB" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Z4</accession>
    <name>F7K6Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01506"/>
    <dbReference type="EnsemblBacteria" id="EGN41980">
        <property type="protein sequence ID" value="EGN41980"/>
        <property type="gene ID" value="HMPREF0994_01506"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1643"/>
    <dbReference type="eggNOG" id="COG2996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064885_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="279" mass="31758" checksum="AE1ED88FA340E020" modified="2011-09-21" version="1">MHIELGKMQELMVVKKVDFGVYLAPEDNQEEKVLLPGKQVPEGCETGDFVKVFIYRDSKDRLIATRKEPKLSLGEVAVLTVAQTGKFGAFLDWGLEKDLFLPFKEQTARVQEGDSFPVVLYVDKSGRLCASMKIYHYLQTDSPYKKDDQVSGHLYEISHQFGAFVAVDDRYSALIPPREMFGELRVGELIQARVIAVHEDGKLDLSIRDKSYRIIETDAVKVMELIESFDGVLPFNDKASPEVIKRETQMSKNEFKRAVGHLLKNGRIEITEKSIRKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7T3</accession>
    <name>F7K7T3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative septation protein SpoVG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoVG</name>
        <name evidence="5" type="ORF">HMPREF0994_01978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be involved in septation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SpoVG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251891.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01978"/>
    <dbReference type="EnsemblBacteria" id="EGN41383">
        <property type="protein sequence ID" value="EGN41383"/>
        <property type="gene ID" value="HMPREF0994_01978"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2174"/>
    <dbReference type="eggNOG" id="COG2088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103669_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00819">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007170">
        <property type="entry name" value="SpoVG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036751">
        <property type="entry name" value="SpoVG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38429">
        <property type="entry name" value="PTHR38429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04026">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160537">
        <property type="entry name" value="SSF160537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="91" mass="10365" checksum="B6D48F6813892B39" modified="2011-09-21" version="1">MKITDVRVRKITKEGKMKAIVSITIDDEFVVHDIKVIEGEKGLFIAMPSKKATDGEYRDIAHPINQATRENIQNIILDRYEKALLEPDEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Y7</accession>
    <name>F7K7Y7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251947.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02034"/>
    <dbReference type="EnsemblBacteria" id="EGN41439">
        <property type="protein sequence ID" value="EGN41439"/>
        <property type="gene ID" value="HMPREF0994_02034"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2233"/>
    <dbReference type="eggNOG" id="ENOG5034B4W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188968_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="69" mass="7318" checksum="E84E1BB9445223C7" modified="2011-09-21" version="1">MDQKAMIDDLVRMLDSGAAKGVGHINVSYDEALPDSKEIQTLGCPDCSAAPLACSVPTLHEGLDETEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K863</accession>
    <name>F7K863_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252025.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02112"/>
    <dbReference type="EnsemblBacteria" id="EGN41517">
        <property type="protein sequence ID" value="EGN41517"/>
        <property type="gene ID" value="HMPREF0994_02112"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2315"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="221" mass="24299" checksum="34BFBE42B49995DE" modified="2011-09-21" version="1">MSILQTTALKKYYGTEPNITRALDGVTLSVEQGEFVAVVGTSGSGKSTLLHMMGGLDTPTSGSIMVREKELAKMNDEQLTIFRRRNIGFIFQNYNLVPILNVYENIVLPVELDGDTADQKFMDEIIQMLGLKDKLKNMPNNLSGGQQQRVAIARALVTKPAIVLADEPTGNLDSKTSADVLGLLKCTSNEFNQTIVMITHNNEIAQLADRIVRIEDGKIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8G4</accession>
    <name>F7K8G4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252057.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02144"/>
    <dbReference type="EnsemblBacteria" id="EGN41051">
        <property type="protein sequence ID" value="EGN41051"/>
        <property type="gene ID" value="HMPREF0994_02144"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_7_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="339"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="481" mass="54019" checksum="CE692AF87BFC90F8" modified="2011-09-21" version="1">MEAEQGSEKNNTTGVALKAGMWYVVSSVMVKAVSVITTPIFTRILTTDEYGYVSTFATWYSLLLVICSLNLTYSIGRAKIDFPDKLDDYIGSSQLLSLLVSVIIAVLMIVFIKPVSSLLTLSEPLVYLLLAYLIFSPAINFAQNGFRYRYKYKQNIAIAWYTAVVTSACSLIFILCFDGDGAFWRCAGLVLPTIILSSAFWINSIRKNRVRVNVEYWKYGMTLSIPLVIHTLSLHILASSDRIFITNICGASDTGIYSLVYQYGTLLSIVTNAVSEGWLPWFHDTYHAGKFEDIRKNVKSIVVLGCYVGLACIAFAPEAISILGGEKYAAGASCVPPIVLGIICQYIYTHYVNIELHLKKTKYVSFGTIFAALLNIVLNVMFIPEYGFVAAAYTTLFSYISLLLIHFIITRKILHVKLYNDSFIFGSFVVTALVSVPLVMTYSMHLIRYILIAVGFASFVFVYHNYIFYYIRKVLHKKNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8I3</accession>
    <name>F7K8I3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">HMPREF0994_02167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252080.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02167"/>
    <dbReference type="EnsemblBacteria" id="EGN41074">
        <property type="protein sequence ID" value="EGN41074"/>
        <property type="gene ID" value="HMPREF0994_02167"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2372"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN41074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="416" mass="44293" checksum="EE4D874C989E276B" modified="2011-09-21" version="1">MKSIYISGNAPLYGEATIQGSKNAALPIMAAALLIPGISVLKNCPHIADVEFMCRILETIGCIVVWDKNEVRIDASAVKTSRLPEEYVTTMRSSVMLMGPMLGRIGEVSLHYPGGCVIGDRPIDIHLKALERLGVCYSDSEQELEAQAVRLNGTDISLEFPSVGATENLIMAATAAEGITCIHGSALEPEIISLCAFLRAAGADIRGEETGCITVVGGRKLHPCCFTVPSDRIVAGTYMCACLAAGGEIFLRNVPRGQLTAMEDVAIRMGCNLRRGQDGMLIRRCGVLFSPGCVETRSYPGFPTDLQSPLLVALSLAEGKSALRETIFNGRFGVVDELNKMGTGILVKGDVACVPGGRRLSGCHVTASELRGGAALVVAGLCADGMTEVANRYFIDRGYEDICRDLSQLGADIDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K928</accession>
    <name>F7K928_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion-translocating oxidoreductase complex subunit G</fullName>
            <ecNumber evidence="6">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rnf electron transport complex subunit G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnfG</name>
        <name evidence="8" type="ORF">HMPREF0994_02366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnfG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252267.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02366"/>
    <dbReference type="EnsemblBacteria" id="EGN40765">
        <property type="protein sequence ID" value="EGN40765"/>
        <property type="gene ID" value="HMPREF0994_02366"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2589"/>
    <dbReference type="eggNOG" id="COG4659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077882_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00479">
        <property type="entry name" value="RsxG_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006091">
        <property type="entry name" value="E_trnsport_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01947">
        <property type="entry name" value="rnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="204" mass="21755" checksum="81B7944A2D7AA5DE" modified="2011-09-21" version="1">MKNMLKDAGILFLITLISGLLLGLVYQVTKDPIAIQEENARQAARSEVFQDADHFEDSEGFTEEAAQAVLNDGGFAQQSINEYAAAMDKDGNVMGYVITVTTHEGYGGDIKFTIGVREDGTLNGMSILSISETPGLGMKAEEVLKPQFEGKKADSYVYTKDGASAADEIDAITSATITTNAVTNGVNAGLYYFQTELKGGSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K963</accession>
    <name>F7K963_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252306.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02405"/>
    <dbReference type="EnsemblBacteria" id="EGN40804">
        <property type="protein sequence ID" value="EGN40804"/>
        <property type="gene ID" value="HMPREF0994_02405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2634"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="255" mass="28319" checksum="55A1ED08F03E12BC" modified="2011-09-21" version="1">MEDILRISNIEKYYGSGGNLTKALSDVSFQVHEGEFIGIMGASGSGKTTLLNCISTIDTVSAGHIFLDGTDVTEIREKDIARFRRENLGFIFQEFNLLDTLTVRENISLALTINRVPAGNIMERVEDMADKLGIRDILDKFPYQVSGGQKQRCACARAMINRPRLILADEPTGALDSHSSQMLLDTIRNMNESLSATILMVTHDAFTASYAGRILFLKDGQIFTEILRGNDSRRRFFGKILDVMTMLGGDLADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9H4</accession>
    <name>F7K9H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252436.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02535"/>
    <dbReference type="EnsemblBacteria" id="EGN40934">
        <property type="protein sequence ID" value="EGN40934"/>
        <property type="gene ID" value="HMPREF0994_02535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_30_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="19423" checksum="038247C3B91EFFE8" modified="2011-09-21" version="1">MKNSEKEQFMILKRIAKQKYELYHFISIQLSISDTEFCILYYFCCSDKLITQNYLSELFPIPEETIHSAIVSLIKKGYVYLEDKMAACEGKGLRLTEDGTAFCQNKIAPVLIGEKNAFSQLTEEERNNLISLSQLHHLFLLKEFNGILDNIRSDANERKMAHMSILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9I6</accession>
    <name>F7K9I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252450.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02549"/>
    <dbReference type="EnsemblBacteria" id="EGN40948">
        <property type="protein sequence ID" value="EGN40948"/>
        <property type="gene ID" value="HMPREF0994_02549"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="398" mass="44366" checksum="F814CF4EB01E68CA" modified="2011-09-21" version="1">MKTFNVRFLYVSKFISQCLPIYAFYTILFINRGMSVPDIAVLMALWSIFTIIFEVPSGVLADRWNRRNMLAIAAVLQGLCFLIWFISHTFLMFVLGFVFWAVAGAFTSGTEEGLIYDNLKCDGRENSFAEVYGKARFYADAGIAAGIVTAGVIVSFVSIEIIALISAAVCFVNVIFILQLREKNYYSERLKEESVGFFGTFKDAAVLIKGSGAALVSLLFLILFACLGDYLDEYDALIINDLQLSHIWVSVILTIRFIFVALGDILASVILKKVFSVRQIFLLYGAACIFLLIFTILWNRCGFIIFGMALAGMVIAEILSVNILQNIIKEEGRATVMSFYGVGQNVVMICFSLVYASLAGIFTLQQVYFIISVYGIAGSLVFCLISVIMKNKDEKYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9S9</accession>
    <name>F7K9S9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02612"/>
    <dbReference type="EnsemblBacteria" id="EGN40595">
        <property type="protein sequence ID" value="EGN40595"/>
        <property type="gene ID" value="HMPREF0994_02612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="37"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="324" mass="34959" checksum="4A8ABDF9E56B2868" modified="2011-09-21" version="1">MDMETNRAMEVVGIGVPYYDMVINVSKMPGLDGAAGANEAFYQGGGKVATAMAAAARLGRRAGIIAKVGENHRGRFVIEDFRYNGVDTSAVIVDAPGTSSPFCLSLSEEEHKTRIFIGKEGTAGELQPEEIDYSYLGKAKYLHLENGRSASEAAARFAKEHGIVTVMDADNYQEGIVKLLPLLDVFIASEFFYRDMFGELDYEAGCRKLMAAGPSTVIVTLGSRGSVGLTEQDGFFKTESFQVPVRDTTGAGDVFHGAYIVGLLEGMNAPECARFASAVSAIKCTCFGGRTGIPDRKTVAEFLETGVIDDTQAQERLAYYRNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAH6</accession>
    <name>F7KAH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252703.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02802"/>
    <dbReference type="EnsemblBacteria" id="EGN40411">
        <property type="protein sequence ID" value="EGN40411"/>
        <property type="gene ID" value="HMPREF0994_02802"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3068"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="33271" checksum="965034454E8F067E" modified="2011-09-21" version="1">MKKLYSNKLVIFSLILPGILVFLFAILAPICLSVYYGCTDYSGMGTAEFIGMENYKLLMKDATFGKSLWHSLLLAIGFICIQHPLAIIVAAVLDKLQGKAEGIFRCIYFIPNVISVAVIAYLWKFIYNPDFGLLNNLLKTLGYTGKINWFDSKIAIWSVLLVLIWHGFGWGMLIYYTGIKNIDPVLYEAASIDGANQRQTFLKITLPQMKSVIQVNVTMAVISALKQMETVYLLTNGGPGDSTQFTANYLYQQAFKAFKYGYGNAISVLFIVICILVTVLLNVIFADRPEKGGRYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAN8</accession>
    <name>F7KAN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mgsA</name>
        <name evidence="3" type="ORF">HMPREF0994_02864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252765.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02864"/>
    <dbReference type="EnsemblBacteria" id="EGN40473">
        <property type="protein sequence ID" value="EGN40473"/>
        <property type="gene ID" value="HMPREF0994_02864"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3133"/>
    <dbReference type="eggNOG" id="COG1803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120420_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="14752" checksum="65053A14CDD1329C" modified="2011-09-21" version="1">MNIALIAHDAKKKLMQNFCIAYRGILTKNVLFATGTTGRLIEEVTNLNVHKFLAGHLGGEQQIGAQIEHNQIDLVIFLRDPLTPKSHEPDVNNVVRLCDIHNIPLATNLATAELLIKSLDRGDLEWREMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAW3</accession>
    <name>F7KAW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252893.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02992"/>
    <dbReference type="EnsemblBacteria" id="EGN40312">
        <property type="protein sequence ID" value="EGN40312"/>
        <property type="gene ID" value="HMPREF0994_02992"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3269"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="327" mass="36480" checksum="ADAC2163D02140AB" modified="2011-09-21" version="1">MSKEAKTKKSEYLVEVNDLKQYFPIKVGVMKTIPLKAVDGVSFAIKPGETLGMVGESGCGKTTVGRSLLRLYTPTGGEVFYNGEKVDGSTIGHMRKEMQMVFQDPYSSLNPRMTIEDIIGEPLDVHKLYSSRGERRDKIINLMELVGLNAEHATRYAHEFSGGQRQRIGIARALATDPKFIVCDEAVSALDVSIQAQVINMFEELQDKLGVAYLFIAHDLLVVHHISDRIAVMYLGRIVEIADSNELNDNPIHPYTQSLLSAVPYPDPKMARERHRIVLEGDVPSPLHMPSGCSFRTRCKYATEQCAKECPSLKDRGNGHQVACWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAY8</accession>
    <name>F7KAY8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252918.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03017"/>
    <dbReference type="EnsemblBacteria" id="EGN40337">
        <property type="protein sequence ID" value="EGN40337"/>
        <property type="gene ID" value="HMPREF0994_03017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065947_4_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="128" mass="15125" checksum="0237CBB090B2166D" modified="2011-09-21" version="1">MLTFPADMTVSQKQAFEKRYRQAAASYFPMRVSYYHQFTGGTYSRITIRGQHTRWGSCSSRGTLSFNWRLMMAPPKVLDYVVVHELCHLKHMDHSRNFWNAVAEVMPDYKEQKKWLKEHGMELFVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBB8</accession>
    <name>F7KBB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253048.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39977">
        <property type="protein sequence ID" value="EGN39977"/>
        <property type="gene ID" value="HMPREF0994_03147"/>
    </dbReference>
    <dbReference type="GeneID" id="29729003"/>
    <dbReference type="eggNOG" id="ENOG5032V2J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125862_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024265">
        <property type="entry name" value="DUF3788"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12663">
        <property type="entry name" value="DUF3788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="153" mass="18189" checksum="D96E05F70B247F9B" modified="2011-09-21" version="1">MNSNENLQLKNPEVMPTREMLENILGGSYAAYEALQDALPNLEMEQEWQWYTPYKAWFARGQHFWTTKRGTKKEKTLYWLYVYEGYFSVAIWFKEKNRMELLNANVSEKTKQLIGDADTMGKLPTFPVVFDIKTIEPLTEIYELLDCKKRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBI5</accession>
    <name>F7KBI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253122.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03221"/>
    <dbReference type="EnsemblBacteria" id="EGN40051">
        <property type="protein sequence ID" value="EGN40051"/>
        <property type="gene ID" value="HMPREF0994_03221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="132" mass="15155" checksum="EBCE2734697C6738" modified="2011-09-21" version="1">MKKLPDAELELMMIIWDAEGPVTRMEIEERMDEGREVLPSTILSLLSRLEERGFVEREKRGKINYYSARVEKEPYLKETGRHILKRMFGGSISNFATALYDGEELSDEDIACLQDFIDSKTGKHTPSGGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBK5</accession>
    <name>F7KBK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253142.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03241"/>
    <dbReference type="EnsemblBacteria" id="EGN40071">
        <property type="protein sequence ID" value="EGN40071"/>
        <property type="gene ID" value="HMPREF0994_03241"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3541"/>
    <dbReference type="eggNOG" id="ENOG502ZC6N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108537_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025368">
        <property type="entry name" value="DUF4272"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14094">
        <property type="entry name" value="DUF4272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="225" mass="25890" checksum="CD3B42E54E19D65C" modified="2011-09-21" version="1">MLLDKKTEGELRKEKSIAFLKKKEVPYIEHLPMIEDSASVKIKAPEVIAKRMVCTLLTIQYSFDIMQGNGGEEGRNFWFAMLEDYEALEELTEKEKHIFSGSASEEELCAMTWKYEAYWVLAWALGFIEELDYPEEVCDCDRAIEIVRDRPELSLLLQAAKPRGIQEILDEADLIYRLDWACVDARIKGNEAPASLNADVVVERHMALNWLIGYDDDWDNVSTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBP1</accession>
    <name>F7KBP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253179.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03278"/>
    <dbReference type="EnsemblBacteria" id="EGN40108">
        <property type="protein sequence ID" value="EGN40108"/>
        <property type="gene ID" value="HMPREF0994_03278"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3583"/>
    <dbReference type="eggNOG" id="ENOG502Z7HS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106583_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="220" mass="24651" checksum="35F7C7AB3F49F542" modified="2011-09-21" version="1">MAQAIAETVFDVLYLSFALIAGLTMLVKGKDPLVKRAGLMAALLGAGDAFHLVPRSYSLWTTGLEANAAALGVGKFITSITMTIFYLILYYIWRERYQIKEKKGLTLTMWVLSILRIALCFLPQNQWLEYRQPLAFGILRNIPFAIMGVIIIVIFAKEAGKGKDPVFRFMPLAVALSFGFYLPVVLFSGVAPAVGMLMIPKTLAYVWIVLMGWKLYRQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBS9</accession>
    <name>F7KBS9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253225.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03324"/>
    <dbReference type="EnsemblBacteria" id="EGN40154">
        <property type="protein sequence ID" value="EGN40154"/>
        <property type="gene ID" value="HMPREF0994_03324"/>
    </dbReference>
    <dbReference type="GeneID" id="29729030"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3635"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969048_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="291" mass="32119" checksum="49417F19DE8B51D2" modified="2011-09-21" version="1">MKGYLKYFRVYFIIILALAAVFLILSIARAGAKTERANTECTTQERVFDYADKLTDSEEDSLRELIAKREKQTGCDIVLVTLNESLEEYAKGYEEQLGSLRPYQYTMVYADNFYDEHMFGYNKPQGDGVLLLDNWYRESDGSVYSWLSTCGKAKDRFSSSMIDNLLNEALEDVDSNPYQAYKKYVNLFYSDMTGKKEIPAAAVILIAAVATAIYIGVNLSRNKGRKTTGVTTYVAGGHPQIRNQSDMFLHKTVTRRHIQRDTGGSGGSGSGGGGGHVSSGGVSHGGGGHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC33</accession>
    <name>F7KC33_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03412"/>
    <dbReference type="EnsemblBacteria" id="EGN39919">
        <property type="protein sequence ID" value="EGN39919"/>
        <property type="gene ID" value="HMPREF0994_03412"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3730"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057076_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="389" mass="42784" checksum="C0068CFD480E58B8" modified="2011-09-21" version="1">MGRMLGKEIAMKKLNIVLVGLGFGGAFVPIYRDHPGVGSIGIFDTDSSVMEEFARAHGIERLYHSFEEILEDEEVDAVHLVTPIPLHAKQTAAVLNAGKHCACTVPMAVSLEEIREITEAVKRSGKNYMMMETTLYTRQFFYAREMLIKGEFGKIQFLRGSHYQDMANWPSYWLGLPPMWYGTHAIAPMRAMAGARICKVHCFGSGTMEEGMEEQYGNPYPVESAIFSFENGLKGEATRTLFETARVYQEGMFVYGSDASFEWGFSDGDNPIITTAVKAADGKRGGTTVVRETVMPNYYSMLPEEIRRHTVGGNYDPLNPQESLISGAAGGHHGSHPHLVHEFVSSILENRKAAIDEVLGANITAAGICAHLSAMQDGAEVVVPVFDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC46</accession>
    <name>F7KC46_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253327.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03426"/>
    <dbReference type="EnsemblBacteria" id="EGN39933">
        <property type="protein sequence ID" value="EGN39933"/>
        <property type="gene ID" value="HMPREF0994_03426"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3745"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073912_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="42"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="185" mass="20676" checksum="92156311ABD55797" modified="2011-09-21" version="1">MENKYYEMNIAGCIRRLPRIRITDSMEIASFVLLGDAELVVKAAAELVKKVPEVDYLITAEAKGIPLIQEMARILDMKRYFVARKSVKPYMIDPFVTEVYSITTQKKQILCLDREESNMIRGKKILIVDDVISTGESLKAMESLVEKAGGKVAGKAAILAEGDAAKRKDIIYLESFPVFPVTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC51</accession>
    <name>F7KC51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253334.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03433"/>
    <dbReference type="EnsemblBacteria" id="EGN39940">
        <property type="protein sequence ID" value="EGN39940"/>
        <property type="gene ID" value="HMPREF0994_03433"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125862_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024265">
        <property type="entry name" value="DUF3788"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12663">
        <property type="entry name" value="DUF3788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="141" mass="15891" checksum="C87CD731103317FB" modified="2011-09-21" version="1">MNWNETFGPSCQPDSEAISSYINCPYWDDLLSYLEETYGAASRTEYSRCSGKPGWNVKYRKGSRGICTLYPDKGFFTCLVSIGSKAADKAELILTACTPYVRKLYAEAPPYNGSRWLMIEVTDSDILQDVKSLIDVRINTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCA7</accession>
    <name>F7KCA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253387.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03486"/>
    <dbReference type="EnsemblBacteria" id="EGN39559">
        <property type="protein sequence ID" value="EGN39559"/>
        <property type="gene ID" value="HMPREF0994_03486"/>
    </dbReference>
    <dbReference type="GeneID" id="29729012"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3812"/>
    <dbReference type="HOGENOM" id="CLU_2585214_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="80" mass="9379" checksum="3472E536C59FDE4A" modified="2011-09-21" version="1">MCLAFEQIEKMAEERGRVIGEKQGEVRGERRGEKRGKVRGENQFAALTEKLLTSSRTEDLLRATKDREYRKKLYKEYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCR1</accession>
    <name>F7KCR1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xylan 1,4-beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253541.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03640"/>
    <dbReference type="EnsemblBacteria" id="EGN39012">
        <property type="protein sequence ID" value="EGN39012"/>
        <property type="gene ID" value="HMPREF0994_03640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3972"/>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028597_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="509" mass="58165" checksum="B48E0F79F5A76A92" modified="2011-09-21" version="1">MIQEKKYTVKKDAKIPFHNNVAYCIGTGRMGLALQKEYQEQLALVQEEIGFSHIRGHGLFSDDMAIYQEYTDENGIKHAEYNFTYLDLVMDSYLSLNIRPFLELGFMPDKMASGKQTVFYWKGNVTPPENYDAWCALVQATLRHLMERYGEQEVVQWPIEVWNEPNLPGFWKDADMEEYFKLFALTFAAIKEVDGRFRVGGPAICGVEDEKWIRCFLEFCRKESIPVDFVTRHHYTTEVPENVGHYGYVKLREPEEGYANLQTTRDIIDSFEEFKGMELHITEFNTSYIPNCPLHDTNQNAAYIAGQLSRLGDMNESYSYWTFGDIFEEQGVPFTPFHGGFGLVANGGIPKPTFWTFKFFADLQGTCVHRTDEAVIVRKEDGSYRGIVWNMTMDGTGEDICRSFRLPMEGIPSGEKGECCILTKTVDEVTCNPLKLWHAMGEPSSLSGEQKKLLKEGARPLVEAQRKELEDGMADVCITVRENGVVYFEVFPVKAGGDRGYCYKRAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCS4</accession>
    <name>F7KCS4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03653"/>
    <dbReference type="EnsemblBacteria" id="EGN39025">
        <property type="protein sequence ID" value="EGN39025"/>
        <property type="gene ID" value="HMPREF0994_03653"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3985"/>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="242" mass="27948" checksum="21CD9B877B858654" modified="2011-09-21" version="1">MLRILFVDDEPFILQGLSVLIDWEKEGFEIAGTAANGLEAIRFLKNNEVDLILADIRMPAMSGLELLEKLRTEGISNAYFIILSGYSDFEYARKALQYGCMDYILKPVRKTELIAALDKVKAESSLTLRKKEEEALQEKAYFARNLIAIICGKYDQMNLEYVTAKMRTDGGIRYIDIEIDDRNEEGSEYEPPKTEEEKRKLQRFLYQSCLDFLGEDGWHCIFDVSSNERDYDIGLIYCDYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCZ1</accession>
    <name>F7KCZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253621.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03720"/>
    <dbReference type="EnsemblBacteria" id="EGN38884">
        <property type="protein sequence ID" value="EGN38884"/>
        <property type="gene ID" value="HMPREF0994_03720"/>
    </dbReference>
    <dbReference type="GeneID" id="29728689"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4060"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478018_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356811" evidence="1">
        <location>
            <begin position="33"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="570" mass="63031" checksum="596D97749B53C722" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCZ9</accession>
    <name>F7KCZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HPr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253629.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03728"/>
    <dbReference type="EnsemblBacteria" id="EGN38892">
        <property type="protein sequence ID" value="EGN38892"/>
        <property type="gene ID" value="HMPREF0994_03728"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4070"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_4_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="76" mass="8625" checksum="E6916214E8FA8874" modified="2011-09-21" version="1">MEHKFITFQNTQQIIQFVNMVNKLDFDVDAKYGSRVVDAKSILGVISLASYKTIEVIFHSDADCNPQINKIFDLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD59</accession>
    <name>F7KD59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03788"/>
    <dbReference type="EnsemblBacteria" id="EGN38759">
        <property type="protein sequence ID" value="EGN38759"/>
        <property type="gene ID" value="HMPREF0994_03788"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356815" evidence="2">
        <location>
            <begin position="25"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="452" mass="50281" checksum="A770FA4F02F625E4" modified="2011-09-21" version="1">MRKWVSAILCITLIGSMLIGCGQKKEDGKETVSKTETETVKTQDSQEASGEPITIQFWNGWTGSDGQVLIELVDEFNKNNPWDITVEMDISSDFGNKFVTSMAAGAGPDLILSSAAGKYSYEGQLADVSDIWDNTTLNKEDFVPTYLDACATDDGLYGIPFQISSYYVYWNKDLFQEAGLDPEMPPKSYEEWTEIADKITNQERHVYGSGLTYGNVGANACLMQMFGGLMVEQNDSGIWEAHFSGNTGYERFVEWFKGQFESGNNPVEGDMDTMFIANQLGLYVTGAWLTADLDSNGINYGITPLPYDEGGKHVPSNTQCFSITNQADNAEKLACERFIQWWHTGNEGTDLTATAVYRWSDEIGYPAYYIPVMNSREYMENPKLKAITVTDTDICADSVAPGNFSGWMSMLNDVMVPFFEQVVYEDNTEGLLEEAQKNADKIVTDINAQEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDW4</accession>
    <name>F7KDW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253944.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04043"/>
    <dbReference type="EnsemblBacteria" id="EGN37568">
        <property type="protein sequence ID" value="EGN37568"/>
        <property type="gene ID" value="HMPREF0994_04043"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4410"/>
    <dbReference type="eggNOG" id="ENOG502Z9EJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068216_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="36175" checksum="FB9C4E9AA5D8FDE2" modified="2011-09-21" version="1">MSEIKINAKYKDRLFRWIFSSKKELLDLYNAVRGTNYTDPEALEITTLEDVVYMGFKNDISFLVDDVLNLYEHQSTYSPNMPVRGFLYLADIYRKYLESRDENLYSSRLVQLPFPQYLVFYNGSREEPDRRVLKLSDAFYRLPGLENTEPSLECRAIMLNINLGHNKELMRKCRKLWEYAKFIQCIRERLAEGKTLEQAVDEAVEACIRDGVLRDFLIGHRAEVRDMILAEYDEERHIASEKQISWEEGNAAGKAIGKAEDILSLLEELGDIPEELRRKILQESDLDVLRKWLKEAAKAESVEAFAEHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE92</accession>
    <name>F7KE92_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">clpB</name>
        <name evidence="12" type="ORF">HMPREF0994_04171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254072.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04171"/>
    <dbReference type="EnsemblBacteria" id="EGN36964">
        <property type="protein sequence ID" value="EGN36964"/>
        <property type="gene ID" value="HMPREF0994_04171"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4546"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="404"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN36964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="868" mass="98000" checksum="715BFF38410AA30C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEH3</accession>
    <name>F7KEH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254159.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04258"/>
    <dbReference type="EnsemblBacteria" id="EGN36538">
        <property type="protein sequence ID" value="EGN36538"/>
        <property type="gene ID" value="HMPREF0994_04258"/>
    </dbReference>
    <dbReference type="GeneID" id="29729083"/>
    <dbReference type="eggNOG" id="ENOG503274J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1263899_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356555" evidence="1">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="193" mass="21504" checksum="4CC71FD07CE13A3B" modified="2011-09-21" version="1">MRKYYGALLAILLLCFLGFTGCLGSGASEVMSNGQSVVEEETVIDHTFTHHRFVDNLFMTLPPDWTYSTYEKVNAGDEMESNEWGFKVYIEGKTAGEIIIAGGFDSEEPTGEEGTDFITNTGLLGKRYTQEAEDENKDVLIKEYIALTVPGFDYAYYAVVCTISKELYEENKEILDSFFMNVGVAAVPIDTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KER3</accession>
    <name>F7KER3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254243.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04342"/>
    <dbReference type="EnsemblBacteria" id="EGN35652">
        <property type="protein sequence ID" value="EGN35652"/>
        <property type="gene ID" value="HMPREF0994_04342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084465_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="267" mass="30121" checksum="D198E48FF1842052" modified="2011-09-21" version="1">MKKYLSFFRLRFITGLQYRTAALAGIATQFFWGAMEILTFRAFYQSDPASFPMTLQATSSYIWIQQAFLVLFMGWNMEAELFDAIRDGNISYELCRPLGIYHMWFARSLAYRLSRAGLRCLPILLAAAFIPAPYGLAAPPDLQAFLLFLLTLFLGLFNVAAFCMLIYMLSFFTITPDGIRIVALSVTELLQGAIIPLPFFPDAVRQILELLPFAAMQNVPLRVYSGDLSGAALEQAILLQFFWLVVMVFAGKILEQRAMKRIVVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KES9</accession>
    <name>F7KES9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254259.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04358"/>
    <dbReference type="EnsemblBacteria" id="EGN35668">
        <property type="protein sequence ID" value="EGN35668"/>
        <property type="gene ID" value="HMPREF0994_04358"/>
    </dbReference>
    <dbReference type="GeneID" id="29726999"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4758"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020573_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028212">
        <property type="entry name" value="GHL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14871">
        <property type="entry name" value="GHL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="653" mass="75301" checksum="5B9EF22F83730AD5" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF09</accession>
    <name>F7KF09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254350.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04449"/>
    <dbReference type="EnsemblBacteria" id="EGN35759">
        <property type="protein sequence ID" value="EGN35759"/>
        <property type="gene ID" value="HMPREF0994_04449"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4859"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="313" mass="34845" checksum="11C550BC2A804206" modified="2011-09-21" version="1">MKGKNTPSGTDWKKTNGKLYLRNNWQLYAMLLIPVIYMILFKYKPMLGVVVAFKKFNIYQGIWDSPWIGLTHFKEAFTSGDFWDALKNTLILNIGDLIIGFPIPIFLAIFLNELRSGKVRKVTQTLLYLPNFLSWVIISGIATQLLANSGMVNNIVNALGGESIPFLSSSGIWRFVYWFSGVWQGAGYSLIVYLAALMATDASLGEAAYIDGATRLQRIWHVTLPQISSTITVLLIMQIGKLVSISFDRPYLMGNTMVRNASNVISTYVYSIGLASGRFDFATAVGLFQTVVGVVLVLLANWVIKRMGQEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF67</accession>
    <name>F7KF67_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04509"/>
    <dbReference type="EnsemblBacteria" id="EGN35819">
        <property type="protein sequence ID" value="EGN35819"/>
        <property type="gene ID" value="HMPREF0994_04509"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4925"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356579" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="383"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="520" mass="57430" checksum="D6094D187F83F367" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFN6</accession>
    <name>F7KFN6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04665"/>
    <dbReference type="EnsemblBacteria" id="EGN34876">
        <property type="protein sequence ID" value="EGN34876"/>
        <property type="gene ID" value="HMPREF0994_04665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5096"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="228" mass="25454" checksum="7EBB766410F5CC4D" modified="2011-09-21" version="1">MVNVLFQKLRRNRIFCGMLHGDMEQKERLKTVDAFRRGCFRFLIATDVAARGIDFESITHVINYDFPTGKETYVHRIGRTGRNGKSGIAVSLVSGEELHMVKQVEAYTGRSLTLLADPGTDEEKEKEFWKSQRIKSAPKPAKGAALNAGIMRLSIGGGRKSKLRASDIVGTICGLEGIEVSDIGIIDIRDSLSYVEILNQKGNMVLEYLQTRPIKGKIRKVRKTRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFZ5</accession>
    <name>F7KFZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34401.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04774"/>
    <dbReference type="EnsemblBacteria" id="EGN34401">
        <property type="protein sequence ID" value="EGN34401"/>
        <property type="gene ID" value="HMPREF0994_04774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007909_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34401.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="970" mass="101053" checksum="839396A526C3DF5E" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG07</accession>
    <name>F7KG07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254687.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04786"/>
    <dbReference type="EnsemblBacteria" id="EGN34413">
        <property type="protein sequence ID" value="EGN34413"/>
        <property type="gene ID" value="HMPREF0994_04786"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5228"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="121" mass="13761" checksum="17BA33C71C2CC9DF" modified="2011-09-21" version="1">MGKKIMVVDDAMFMRKVICKNLQECGYTDIIEACDGEKALEMYAIYKPDLVLLDITMPGISGIEVLEEIQREDPQSRIVMCSAVGQEQMIQQAVMLGAKDFIVKPFRPDEFRRIVRNALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG20</accession>
    <name>F7KG20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254700.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04799"/>
    <dbReference type="EnsemblBacteria" id="EGN34426">
        <property type="protein sequence ID" value="EGN34426"/>
        <property type="gene ID" value="HMPREF0994_04799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1018212_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="147"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="266" mass="30760" checksum="8397D51B7AAB174D" modified="2011-09-21" version="1">MNNMELLADALSYIELNLCETITAESVARNCFCSKSGLEKLFRNVYHYGVKEYVIKRRMTKAARELVRYPEATVLDIALRYSYQSHEAFTRAFQQVWGCSPSVFRKEKRFTDIFPRLLQLFEKGDAYMKQRKPVDISELYDLFLERKDCYFICCDIKGLVPINEISYKAGDLAILETVRRMEKCAGDEDIIFRIGGDEFVLLTASRDIAYAQELAEGISGMNGEMICFEGQEISLALHTGITKFEGRHLKYDELFVWLHQAILDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG39</accession>
    <name>F7KG39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34445.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360161.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04818"/>
    <dbReference type="EnsemblBacteria" id="EGN34445">
        <property type="protein sequence ID" value="EGN34445"/>
        <property type="gene ID" value="HMPREF0994_04818"/>
    </dbReference>
    <dbReference type="GeneID" id="29728059"/>
    <dbReference type="eggNOG" id="ENOG50314PV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1649964_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34445.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="160" mass="19212" checksum="28F8D31256815079" modified="2013-09-18" version="2">MKKKKNEYAYDFNEDKEYYIYLNACRKKIGKKKLMIIGENNYSNYDEWSGYVNQKYSCITTKSLVAFKRHLKYQIRASGRIEGSYSAVLLPLIITWVTIMLDRFFPSDAINNFLCIIIFVYLFWELLKNYFGDTKKSLMYEDYLEIIENIIESRKMKENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGP1</accession>
    <name>F7KGP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33815">
        <property type="protein sequence ID" value="EGN33815"/>
        <property type="gene ID" value="HMPREF0994_05020"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114686_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="28848" checksum="7832A8ECAF4BA9C0" modified="2011-09-21" version="1">METSIFLNKVTEWMNLRALFITGRKIKKGTSMKHKYCIFILTAISLLLLTGCGESSKKENVWDPPIEGLTWGMSSEEVKKIYPFIDETAEKDGTFWVTLEDKIQVYGISMEVSMSFFESKELMLGLQNMTLKCPEEHIGKLEKELEKRFKDTADPTTDEYGWISWVTGEVISDYYTAEQLKEAYTKRLGEEYMSAHSDYYNGYIAGLPRSYLASYQLKYKGEDSGFMEINGVRLAEMKYLFGEDWKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGS5</accession>
    <name>F7KGS5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254955.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05054"/>
    <dbReference type="EnsemblBacteria" id="EGN33763">
        <property type="protein sequence ID" value="EGN33763"/>
        <property type="gene ID" value="HMPREF0994_05054"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5520"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_31_8_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="78" mass="8520" checksum="4A7445D2158C00F5" modified="2011-09-21" version="1">MSIIINLDVMMAKRKKGLTELAGEVDITLANLSILKNNKAKAVRLSTLNAICKALECQPGDILQYVEDEEEDNGSNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGX4</accession>
    <name>F7KGX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255004.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05103"/>
    <dbReference type="EnsemblBacteria" id="EGN33136">
        <property type="protein sequence ID" value="EGN33136"/>
        <property type="gene ID" value="HMPREF0994_05103"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5576"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017436_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="154"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="341"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="416" mass="47752" checksum="656EA5CE7BC4290B" modified="2011-09-21" version="1">MNCEDLMNMESIRKGMKLIAGEKGIDRTIRWIYFADCVQCLSADFNVAELIHGEELVIITNESLTENDSRLIDMIRVMQEKNIAALAVNEGQISKGLASYCNEVELPLFELSVSLHLIDLSQIVCKALVEEESFTNSRERILSTILYSDNLNVEELLEQANYLGINLSGKYRCFLLQLHQREKLPNDTSRMDEGYMMEMRGNIKKMVKKEFRSHGLERLMVLPQLDSVIGLIPGEFFSHDLLQIILEKIIGRVESSYHIDVKAGIGTSYEYIEDFRKSYQEAKNTLAISKISADEKKVYFYEKLGIYSLIAQISNGKFLDDYVESRIGELIKADQMQEGGLCETLETYLAHNCNANAAAEYLFIHRNTMRYRMDKIKRILDDDINDMEVFLELKLAFAIKRYRENRAADDSSGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGZ1</accession>
    <name>F7KGZ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255022.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05121"/>
    <dbReference type="EnsemblBacteria" id="EGN33154">
        <property type="protein sequence ID" value="EGN33154"/>
        <property type="gene ID" value="HMPREF0994_05121"/>
    </dbReference>
    <dbReference type="GeneID" id="29726240"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="31190" checksum="C86BD92D22A43F09" modified="2011-09-21" version="1">MKKILLSETNPDAYMEVYAEPSEKAKPAVLIYPGGGYYALSDTERLPIVEFYRENGFQPFIIMYSIGIHAHYPDPLTEGSKAVWEIRKNAGKYCVNPDQITLVGFSAGAHAATMLANLWHKDISRKGTDIPEGGNRPNATVTGYTPTTFEDFYIKFPDAMKLELGNPESGPKNLLGGKESGFEEFSSMTTIGMISKLTPPAFLWKTTADFPESSLEYALACKKNGVDYELHIFNDDSRCAAMEFDQKRAVNYNPNFEKNTQMWPEMSVNWLRKIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH05</accession>
    <name>F7KH05_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="13" type="ORF">HMPREF0994_05139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255040.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05139"/>
    <dbReference type="EnsemblBacteria" id="EGN33172">
        <property type="protein sequence ID" value="EGN33172"/>
        <property type="gene ID" value="HMPREF0994_05139"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5616"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="646" mass="72612" checksum="C21581E3E09AA83D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH20</accession>
    <name>F7KH20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255057.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05156"/>
    <dbReference type="EnsemblBacteria" id="EGN33189">
        <property type="protein sequence ID" value="EGN33189"/>
        <property type="gene ID" value="HMPREF0994_05156"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5636"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="33486" checksum="97030C7DA7B179E8" modified="2011-09-21" version="1">MAARGLGKGLDSLIPNTIGESKGKADKGTGTENKNPETMVKLTAVEPNRDQPRKNFDEDALLELAESIKQFGLLQPILVQERDGYYEIIAGERRWRAAKIAGLKEVPVIIKNLTDQEIVEISLIENIQREDLNPIEEAQAYKRLLNEFHLKQDEVAERVSKSRTAVTNSMRLLKLCDEVQQMVVNEMITTGHARALLSIEDPEEQYMIAQKVFDEKMSVREVEKLVKNLHKPEKPKKAENKSLEVIYQNIEEKLKESLGTKVSISSKDNGAGKIQIEFYDHDDLDRLMEYIIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH50</accession>
    <name>F7KH50_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255083.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05186"/>
    <dbReference type="EnsemblBacteria" id="EGN33219">
        <property type="protein sequence ID" value="EGN33219"/>
        <property type="gene ID" value="HMPREF0994_05186"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5667"/>
    <dbReference type="eggNOG" id="ENOG5033GVX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206505_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="65" mass="7537" checksum="418EF224B997919C" modified="2011-09-21" version="1">MKEEKLIIHPKRPKGDDGYKTFSVHIREDVVQRIDEISAQTGRSRNELIGILLEFSLDRCSIEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH59</accession>
    <name>F7KH59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006776320.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05195"/>
    <dbReference type="EnsemblBacteria" id="EGN33228">
        <property type="protein sequence ID" value="EGN33228"/>
        <property type="gene ID" value="HMPREF0994_05195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5674"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043385_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="351" mass="39813" checksum="D2A8CB4DDB6D6295" modified="2011-09-21" version="1">MNESTTNMRTEEAIKEKIKESRFESINGKDLMEMDLPPLHYTISTILPHGFFILAGGAKVGKSWLAEQISYAVASGGQIWGYQAIQSEVLYLGLEDTVTRLQSRFEMLEAYEGMENIHFVLKANSITSGVEEDIRDYLTQHPNIKLVVIDTLQHIRGNEFVKNIYAGDVEFTNILRQISMEFDLTILALTHTNKGKHDDDISKISGSEGMAGGTDGNWVLTKSKRTDTRANLTISNRDTEAFEFALEFDKESCRWNKLTRDESVVNEKERFLHAIVNFVKAEEAHHWEGTATELLTNLQAREPILVSYSAAVFSKSLKAAQDSLREIYGVSYVSAFHNKKKWITLDYIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHD9</accession>
    <name>F7KHD9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="10" type="ORF">HMPREF0994_05140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255041.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05140"/>
    <dbReference type="EnsemblBacteria" id="EGN33173">
        <property type="protein sequence ID" value="EGN33173"/>
        <property type="gene ID" value="HMPREF0994_05140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5617"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="365" mass="41805" checksum="A71049D2B6AA14DC" modified="2011-09-21" version="1">MVIKSLELSNFRNYAFLDMNFDKGTNILYGDNAQGKTNILEAIYLCATTKSHRGTKDRDIVNFDEEEAHIRTYLEKDGDEIKIDMHLRKNKTKGIAIDGTKIKRASELLGLMNVVFFSPEDLSIIKNGPSERRRFVDMELCQLDPMYLHHLNNYNKIINQRNKLLKDMYMNPSLKGTLDVWDIQLVEFGKKIIERRTAFVDQMNTIIGGIHDSLSGGKEKLLLSYEPDISPEDFEGKLRGSQERDIRLKQTTVGPHRDDFAFIANEIDIRKFGSQGQQRTAALSLKLSEIELVKTMTKDTPILLLDDVLSELDSNRQNYLLNSIGDIQTIITCTGLDEFINNRFEINRVFKITNGSIDIMSIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHH4</accession>
    <name>F7KHH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255146.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05303"/>
    <dbReference type="EnsemblBacteria" id="EGN33038">
        <property type="protein sequence ID" value="EGN33038"/>
        <property type="gene ID" value="HMPREF0994_05303"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="35071" checksum="385A50E76ACB3AFF" modified="2011-09-21" version="1">MAKKEAEEKVRVGKKSAGDWAVDIFITIIFGLFTIVCIFPFYYIFINTISNNNLVMTGKISLFPQGIHFQNYVRVLTLKELPPALFVSIARTVLGTIFTVFAASFPAYAFTRNEYWGRKFFYRFVVVTMYFSAGLIPLFLTYRTIGIYNTFWVYIIPGIVTPFNLILCKTYIESLPASLEESAEIDGAGYLVRYFRLILPLSKPILATVSVFSAVGQWNNWMDTVLYTKDKSLQTLQYVLYRYLNEANTLAEIAREDPSAMNADLATQLSPLTIKYTISIVTILPILLVYPFFQKYFVKGIMIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI21</accession>
    <name>F7KI21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571026.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05523"/>
    <dbReference type="EnsemblBacteria" id="EGN32964">
        <property type="protein sequence ID" value="EGN32964"/>
        <property type="gene ID" value="HMPREF0994_05523"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBQF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123819_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="155" mass="17278" checksum="04EA8ED18B8AF1D7" modified="2011-09-21" version="1">MAYVPVPKDLTKVKTKVAFNLTKRQLVCFGGGALLGVPLFFLLRGSAGNSTAALCMMFVMLPFFLLAMYEKHGQPLEKIVGNIIRVTVIRPRQRPYRTNNFYAVLQRQANLDEEVSHIVYGNQTLAAPAVRKKRGKSCAAGQNKEKAVPRRQKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI64</accession>
    <name>F7KI64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05543"/>
    <dbReference type="EnsemblBacteria" id="EGN32368">
        <property type="protein sequence ID" value="EGN32368"/>
        <property type="gene ID" value="HMPREF0994_05543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="31698" checksum="D57CB4B1B1A361AB" modified="2011-09-21" version="1">MLFQNKKNMDVRKDSHWRDVARNFTRHKLAMTATVIILSEIILVIVLPVFLKLDPNMITPSFYAAPGGGMLLGTDEVGRNVFARLLEGGRMSLLIGISSAIISALIGIPLGLLAGYMENAVRPVILRITDIFMAIPMMIAAMFIVAMVGSSAWTVIVVIGLLGWPGFCRLAYGRVISVKENEYVEAAKAIGTKTSRIIFKDILPNSVAPLLVAFSGSVAGAIVTESSLSFLGVGIQPPQASWGNMVYAAQSLSVLTNNWWMWMPAGLCLVVTVLSINFIGDGLRDALDPKMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIC6</accession>
    <name>F7KIC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette, subfamily F, member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255412.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05605"/>
    <dbReference type="EnsemblBacteria" id="EGN32316">
        <property type="protein sequence ID" value="EGN32316"/>
        <property type="gene ID" value="HMPREF0994_05605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6122"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="324"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="657" mass="75776" checksum="56AD8AA4C299B866" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KID5</accession>
    <name>F7KID5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05614"/>
    <dbReference type="EnsemblBacteria" id="EGN32325">
        <property type="protein sequence ID" value="EGN32325"/>
        <property type="gene ID" value="HMPREF0994_05614"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6133"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="32904" checksum="974F33DBC75333A1" modified="2011-09-21" version="1">MKNRKANITFHAMIAPGMIFILLFNIIPLAGFIMAFQNFLPAKGLLGSKWVGLDNFKFMFQLPDSRQIFVNTLVIAVSKMILNLLVPLVFALMLNAIRCKLLKRTLQTIVYLPNFISWVILGSIIADIFSKSGIINTLLSGVGIEPIIFMGSNTWFRPIVILSDVWKGFGYNSIIFLAALAGIDPTLYEASAIDGATRSKQLIYITLPSIVSTIVLVGTLSLGNVLNAGFDQVFNLYNPLVYRTGDIIDTYVYRMGLQNAQFSLATAVGMMKSVISFLLIIISYKLAEKFANYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIJ3</accession>
    <name>F7KIJ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05672"/>
    <dbReference type="EnsemblBacteria" id="EGN32161">
        <property type="protein sequence ID" value="EGN32161"/>
        <property type="gene ID" value="HMPREF0994_05672"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6196"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050934_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="344" mass="39810" checksum="FBE12080A45BC7D2" modified="2011-09-21" version="1">MKRRGELLRRQIGICIFTWKARQGYDKIALLHPAGDYYNRKAQNKMKLLITGGTVFVSKFTAAYFAGRGHEVYVLNRGTRPQAEGVNLIKADRNSLGSALNGMYFDAVIDVCAYKEADINNLLNAGIKFDDYVLISSSAVYPETLPQPFNERQPIGKNSIWGDYSSGKVGAEVCLTSRYPNAYVIRPPYLYGPMQNLYREPFVFECADLKRKFYIPGDGEMKLLFFHVEDLCRFIYIILREHPDNHIFNVGNTQPVSISTFAELCYRAAGAPLEKVFVKDHPNQRDYFSFHNYEYLLDVSLQNEIMPEQKDLYCGLKESYEWYKSNKEEVRKKPYIDFIDRNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIQ3</accession>
    <name>F7KIQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569190.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05740"/>
    <dbReference type="EnsemblBacteria" id="EGN32229">
        <property type="protein sequence ID" value="EGN32229"/>
        <property type="gene ID" value="HMPREF0994_05740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6277"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="558" mass="65254" checksum="7C97E95BA173940F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ24</accession>
    <name>F7KJ24_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255629.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05853"/>
    <dbReference type="EnsemblBacteria" id="EGN31481">
        <property type="protein sequence ID" value="EGN31481"/>
        <property type="gene ID" value="HMPREF0994_05853"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6404"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="35740" checksum="744E012D07A309E9" modified="2011-09-21" version="1">MAVTTVKKDRKTKRKRSGRMSREKLKGQLEIQSMVWPGLIFLFIFSYLPMYGISIAFKDFNIMSGFIGGDFVGLKYFSQFLTDPKLPLVLKNTIMINLLGLVIGFPAPVILAILITELRGRRFRKLAQTVSYLPHFLSWVIFGGIMLELLASGGIVNKGLNLFRLAEGNMNLMADPNKFYMIFTVISIIKSIGYGSILYISAITSVDQDMYEAAYIDGANRFQKIIYITVPAIMGTIVIMLIFQISNILNTGFEQVLILQNSLNISASETIDTYVYKIGMTQQRYSYATAVGLFKSIIAVVLLWSANKCSNKITGKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ32</accession>
    <name>F7KJ32_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05861"/>
    <dbReference type="EnsemblBacteria" id="EGN31489">
        <property type="protein sequence ID" value="EGN31489"/>
        <property type="gene ID" value="HMPREF0994_05861"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6413"/>
    <dbReference type="eggNOG" id="COG2240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046496_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="126"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="34876" checksum="533297955D0472AA" modified="2011-09-21" version="1">MTEQMMPDRPSRPFRIPKKIAMINDIAGYGRCSTTVSLPIISAMQVQVCPVPTSIFSNHTGFPVHFMHDCTDILPEYLEKWQELELTFDGIYCGFLGSVTQIGIVKDFLASQTGNAGHSRISADGNRPIVILDPVMGDHGRAYRTITPQHCEEMKELLTMADIITPNITEACLLTGAAYRESGWTAEELKELTEKLHSMGPDKIVITGMQDGDDFVNFISVKKGPEELPDCSNSSCRDCFNGYCCGCCRMHIAGESRPGTGDIFASVIAADAVNGVDFFQSVEKAAGFVRICTQASSELDIPRKQGVCFENFLYMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJH9</accession>
    <name>F7KJH9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255786.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06010"/>
    <dbReference type="EnsemblBacteria" id="EGN31364">
        <property type="protein sequence ID" value="EGN31364"/>
        <property type="gene ID" value="HMPREF0994_06010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020211_13_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="5">
        <location>
            <begin position="332"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="439" mass="50883" checksum="B1D6B2FAD9344424" modified="2011-09-21" version="1">MKHLILSIIQNILFFLEAFSITFFLLRFCKCKCEERRMQVLVFQTMVMAVLCTWSSYIPYFTGFILFAYFPCILIFSILFLDGAFGQKLKGCLLVLCIKLLTLLAAVMITMRCGDWTLEELYYDFEWYKMAVMLLERAFQIVMFGWVLRAEGKLPVRMKRLEKGVVLSNLITSAITFGIIHDISYGNVSSEWKAYLFILSLLCLVIMNGITFYLMEKLHQRNELASDNKMLRQRVMYYESHLEQTHEQIEELKQMRHDIRHSYQLISNLASLGKNREIEQYISEVLDIVNREEYIAATGNEFVDSMLCYKLSYAAKKGIKVVHSVTAGLEGIENVDCCNLIGNLIDNAIEANLKLPEGKRKLELFIKGDPCKLFIRVRNILETSVLDTNSGLATQKKDKDVHGYGIRIIRKIASQYNGYVQFTEEEGFFCAEVMLFRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJU3</accession>
    <name>F7KJU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06122"/>
    <dbReference type="EnsemblBacteria" id="EGN30748">
        <property type="protein sequence ID" value="EGN30748"/>
        <property type="gene ID" value="HMPREF0994_06122"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6702"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392216_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="777" mass="85502" checksum="EADDFE77B9C19EAB" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJV7</accession>
    <name>F7KJV7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255912.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06136"/>
    <dbReference type="EnsemblBacteria" id="EGN30762">
        <property type="protein sequence ID" value="EGN30762"/>
        <property type="gene ID" value="HMPREF0994_06136"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6719"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075245_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="5">
        <location>
            <begin position="192"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN30762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="320" mass="34085" checksum="6D65B7A8B9809127" modified="2011-09-21" version="1">MNEVLEQIRKIGIVPVVKLDRVEDAVPLAESLCKGGLPCAEVTFRTAAAAGAIAAIRKAFPDMLLGAGTVLTTKQVDEAMEAGATFIVSPGLNPEVVKYCVDNKIPVTPGCSNPSDIEQAISLGLDMVKFFPAEAAGGLAMIKAMSAPYVNMKFMPTGGISAKNLNEYLSFNKIIACGGSWMVKDDLIKAGEFDKIEALTREAVEQMLGFELAHVGINETDEEAADKTAGRFESIFGLEKKTGSGSVFAGTAVEVMKTPGLGAKGHIGIRTNYIDRAVNYLENQGVEFNPSSAKYDDKGNLKAIYLKEEIGGFAVHLVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK27</accession>
    <name>F7KK27_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-mann_mid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255997.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06221"/>
    <dbReference type="EnsemblBacteria" id="EGN30714">
        <property type="protein sequence ID" value="EGN30714"/>
        <property type="gene ID" value="HMPREF0994_06221"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6816"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041509">
        <property type="entry name" value="GH38_beta-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18438">
        <property type="entry name" value="Glyco_hydro_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="296"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="901" mass="103220" checksum="95D7BE5CB1E2850E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKD1</accession>
    <name>F7KKD1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256080.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06310"/>
    <dbReference type="EnsemblBacteria" id="EGN30178">
        <property type="protein sequence ID" value="EGN30178"/>
        <property type="gene ID" value="HMPREF0994_06310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6913"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058590_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="182"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="389" mass="45520" checksum="5F80D5DF52E6CB05" modified="2011-09-21" version="1">MNHSERILMTLGFEKRTERGAVLETFFPWDKTINRWCEEGLPKEYSPSRLYPPTDGYMGRYLSDQMSDPVYAYERYLGFDGVKRMAFRIPFSCFDETVMEETDTYIVRLDTDGWVRKYHRNSNLVEEVKAPVTGEEDWNALKEKVREHLALYCTDENIRKVYGRYVAGHEAGDYSIRFRLTGFFWLSRMLMGIEEQMYAFYDMPEVLHDMNQFAVDIYKEYLDKVFDIIQPEVLLLEEDLSGCNGPMISPDIFNEFVGDYYRQLFPFLKEKGVKNVFIDTDGDFNRLIPDFIEAGVDGFLPMDVNAGMDIVKVRQLYPGLKFIGGFNKLTIEEGKEAIDREFERILPVIRSGGYVPGCDHQATPDSSFDNYRYYIKRLKEVMEEAGRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKK2</accession>
    <name>F7KKK2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na_H_antiporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_06381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06381"/>
    <dbReference type="EnsemblBacteria" id="EGN47989">
        <property type="protein sequence ID" value="EGN47989"/>
        <property type="gene ID" value="HMPREF0994_06381"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6983"/>
    <dbReference type="eggNOG" id="COG1757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018751_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356701" description="Na_H_antiporter domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="8">
        <location>
            <begin position="193"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN47989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="538" mass="57054" checksum="E3E59C53E556A8BA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKL2</accession>
    <name>F7KKL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256153.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06391"/>
    <dbReference type="EnsemblBacteria" id="EGN47999">
        <property type="protein sequence ID" value="EGN47999"/>
        <property type="gene ID" value="HMPREF0994_06391"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6997"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="171" mass="19982" checksum="D401DCEB09C13D7E" modified="2011-09-21" version="1">MDKDFLLINKMKNGDESAMESFVCRYYPKILCYCHYHVSDKGYAEDITQETFVKFFGALSVYRHHGKALNYLYTIAANLCRDFYKKSTSLPVPDIPDACGNTMDFVDCRLDMEEALRRLPGELREILILYYFQERKQREIADILGIGLPLVKYRLKQAKEQLGQLLGKERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKM3</accession>
    <name>F7KKM3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256164.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06402"/>
    <dbReference type="EnsemblBacteria" id="EGN48010">
        <property type="protein sequence ID" value="EGN48010"/>
        <property type="gene ID" value="HMPREF0994_06402"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7008"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022070_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="717" mass="83643" checksum="B042F016372C7E33" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLQ9</accession>
    <name>F7KLQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256541.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06788"/>
    <dbReference type="EnsemblBacteria" id="EGN46380">
        <property type="protein sequence ID" value="EGN46380"/>
        <property type="gene ID" value="HMPREF0994_06788"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7418"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="34502" checksum="DB13A244718077DE" modified="2011-09-21" version="1">MKKSRKTKKFFKNGSLHLMMMPALILLLIYNYIPLAGNIMAFQKFNPSKGFFHSKWVGLKNFQYVFHLPDIYQVIWNTFYIAILKIIMGIVIPVIVALLLNEIRKMKFKRTIQTMIYFPHFLSWVILAGVFVDVLSPSNGVIGKAFTAMGLEPIFFLGDSKWFPYTMVLTDTWKEFGYGTIVYLAALTGIDPSLYEAAVMDGANRWKQTLHVTLPGILPIVMLMSILAMGNIFNAGFDQIFNMYSPQVYSTGDILDTLVYRIGMLDAQYGVATAIGLFKSVISFAMLGISYMVAYKYTDYRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLS0</accession>
    <name>F7KLS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256552.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06799"/>
    <dbReference type="EnsemblBacteria" id="EGN46391">
        <property type="protein sequence ID" value="EGN46391"/>
        <property type="gene ID" value="HMPREF0994_06799"/>
    </dbReference>
    <dbReference type="GeneID" id="29726716"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7430"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357549" evidence="1">
        <location>
            <begin position="37"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="604" mass="66566" checksum="E25FE2A63ACD1C6E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLS3</accession>
    <name>F7KLS3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN46312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06802"/>
    <dbReference type="EnsemblBacteria" id="EGN46312">
        <property type="protein sequence ID" value="EGN46312"/>
        <property type="gene ID" value="HMPREF0994_06802"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7432"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="628" mass="72516" checksum="664E83579F805DA9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS67</accession>
    <name>S2KS67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05132">
        <property type="protein sequence ID" value="EPC05132"/>
        <property type="gene ID" value="HMPREF0994_07187"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3001051_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="56" mass="6720" checksum="68ACA4877A47543C" modified="2013-09-18" version="1" fragment="single">FKISYITIKQNGSENGRSRKYHFKISYITIKQYDLTIRQIENVYFKISYITIKPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSF9</accession>
    <name>S2KSF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EPC05222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07133"/>
    <dbReference type="EnsemblBacteria" id="EPC05222">
        <property type="protein sequence ID" value="EPC05222"/>
        <property type="gene ID" value="HMPREF0994_07133"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_26_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="249"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="514" mass="58534" checksum="3BC4FEC514AA53F5" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVW8</accession>
    <name>S2KVW8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360151.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07205"/>
    <dbReference type="EnsemblBacteria" id="EPC05150">
        <property type="protein sequence ID" value="EPC05150"/>
        <property type="gene ID" value="HMPREF0994_07205"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923690_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="35224" checksum="225A626CC60AF450" modified="2013-09-18" version="1">MNENYPCDIIQDLLPGYIDEILSETGTRVVKEHLEECEKCNHVYLEMKEGLNSEEELNETLALDGFKKVQQHTKKLKITIGIFAGLLTLLLLSIFLKVFVIGELLSSHEVNATNISYDEKTESLTISGTINLSSYHISRVVWEESKEEADVVHVLVYGAENLPFQQKKTDFTISIPNMKGKTAYLASPEYDRLEVYSWENDHYEKLAELEDEIYSRLPELDKDKDALSYISGIEYVNGIEGICYYVDTVVGENASYWRFNNQLITDGDFEPQNFAVWISLDKPYQILIYNLETGEYTEDYSIIRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K320</accession>
    <name>F7K320_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250198.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00249"/>
    <dbReference type="EnsemblBacteria" id="EGN37888">
        <property type="protein sequence ID" value="EGN37888"/>
        <property type="gene ID" value="HMPREF0994_00249"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.270"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="184" mass="20050" checksum="C56F259ED5E94F14" modified="2011-09-21" version="1">MKKIVILNGSPRTNGNTKALIECFTKGAKSAGNEVTCFDLQKMNIHGCLGCCKGGQNPESPCVQKDDMQQIYPVYREADVVVLASPMYYWGISGQLKCAFDRLFAVAECSPDYENPKKECLLLMAAEGNTESNFAPVKAYYEGLLSHLGWKDAGIVYAGGNMDPGDIRDRPEQLAQAEALGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K332</accession>
    <name>F7K332_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00261"/>
    <dbReference type="EnsemblBacteria" id="EGN37900">
        <property type="protein sequence ID" value="EGN37900"/>
        <property type="gene ID" value="HMPREF0994_00261"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.283"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_13_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="86"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="35190" checksum="4B20ADC3593BE51F" modified="2011-09-21" version="1">MALFDKSMNALKKNKEQEQNQNLMKLIKRVHSVVENTDIEKHRQSQDYFGALLGSSKDMDICPVEVEGMHCEWVRTNRVHMKKYVILYCHGGGYSTGSCVYARTLTTKLAASTSMDVFCFDYRLAPEFPYPAAMEDAMKAWNYLMLLGYGSRDVIVMGDSAGGNMALSLVVKLKEQERLMPRGIVLLSPWTDLTASGKTHESRAELDPVLDEEYLKQMTENYAAGQDYEDPLISPLFADLTGFPSTYIQVGDNEVLLSDSTMLHKKMIKANVPVRLDVFKGMWHVFQMSPFKTAYEAMDQCAEFIFDICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K370</accession>
    <name>F7K370_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00299"/>
    <dbReference type="EnsemblBacteria" id="EGN33440">
        <property type="protein sequence ID" value="EGN33440"/>
        <property type="gene ID" value="HMPREF0994_00299"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.322"/>
    <dbReference type="eggNOG" id="COG1237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="287" mass="31398" checksum="CCD7765144ED7842" modified="2011-09-21" version="1">MKITILTENTVSRRGLLAEHGLSVLIEAGNRRILFDTGQSGVYLHNAQKLGISLEGLDGIVLSHGHYDHAGGLPEFPAAADCPVFLSEKALEDKWCLEKNGGPARCIGIPWREESGDGQIPGRLTFTAEKEEIFPDIYVLGGITSTVPEEAARDNLFRIRRDGQFIPDRMEDEQLLILRTARGLAVFAGCAHAGILSCLEKVRTSFPGEKCFFLLAGMHLRGCGEEQVNAVIDGLKQYGFSILIPLHCTGTLATARMRMAFGRSCLMAEAGKSFLIPEEETENRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3I5</accession>
    <name>F7K3I5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN31929">
        <property type="protein sequence ID" value="EGN31929"/>
        <property type="gene ID" value="HMPREF0994_00414"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030FM1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1783536_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="17341" checksum="131A9328ED198258" modified="2011-09-21" version="1">MKQCPNCEELVGDDVKECFNCHYNFIYKRVMNPNEVMDMRNANERLQQEREEKQREKERQKEAQLKKNALYEYKTVIINDLSTGEIDGPAVERALLEYAEKGWRLHTIFTNEVGKTVTPMMFIQINLNATIDQTVMVFERCIKPDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3L2</accession>
    <name>F7K3L2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small GTP-binding protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250390.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00441"/>
    <dbReference type="EnsemblBacteria" id="EGN31956">
        <property type="protein sequence ID" value="EGN31956"/>
        <property type="gene ID" value="HMPREF0994_00441"/>
    </dbReference>
    <dbReference type="GeneID" id="29726317"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.483"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="620" mass="69707" checksum="BB14848CE4FD7D99" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3L7</accession>
    <name>F7K3L7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00446"/>
    <dbReference type="EnsemblBacteria" id="EGN31961">
        <property type="protein sequence ID" value="EGN31961"/>
        <property type="gene ID" value="HMPREF0994_00446"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.490"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395759_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041172">
        <property type="entry name" value="EstA_Ig-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18435">
        <property type="entry name" value="EstA_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="446"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="696" mass="77442" checksum="100E07F912322778" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Y1</accession>
    <name>F7K3Y1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Basal-body rod modification protein FlgD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for flagellar hook formation. May act as a scaffolding protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the FlgD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00560"/>
    <dbReference type="EnsemblBacteria" id="EGN44748">
        <property type="protein sequence ID" value="EGN44748"/>
        <property type="gene ID" value="HMPREF0994_00560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.608"/>
    <dbReference type="eggNOG" id="COG1843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097483_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="26031" checksum="DE2B0EA12570DFE1" modified="2011-09-21" version="1">MAVDGLNSSYDTYASAYARSTENTAGESSGTGNVIDAVFEKESDRQVSIDDFLVLMVEQLKNQDFMNPVDDTQYVTQLAQFTTMQQMQELAYNAKSTYATSLVGKDVTAAKITVNGDLATTEGPVEKVSLLDGEYVIYVGGKGFTLDEIMEVKPSSQSDGALKKISSQLEDMNKMLDGKLTEGFESIRNAADSGAAGSADGNKVTGGTQGSGSADGNEGTDGSGNADGVGGVEGSGNAGGTGDGSNADSPEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K422</accession>
    <name>F7K422_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250562.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00613"/>
    <dbReference type="EnsemblBacteria" id="EGN44801">
        <property type="protein sequence ID" value="EGN44801"/>
        <property type="gene ID" value="HMPREF0994_00613"/>
    </dbReference>
    <dbReference type="GeneID" id="29726633"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.666"/>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="219"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="30801" checksum="F631AB507A711E12" modified="2011-09-21" version="1">MVGSMFAAISGLKSHQTKMDVIGNNIANVNTWGYKAQSANFMDATYRTTIAGSAGSATVGGVNSSQIGYGANVGSVTVNYSTGNRNPTGWGGDCMIDGPGFFIVSASPLANPIPNGTPLTSNDGIMLSRVGILAFDSEGNLVDDQGSFVLGYGLDGNGAVNTGLDMIKAKNGQTYTSISVQTDGTITAVVEKDTTGTNNPGDVVTLGRLGVASVNNPSGLDKTQGYYYKIGPNAGDVSHGESNAATGKILSGYLEMSNTDLSTEMANMITTQRGFQANTKIITVTDQMLEELVNMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K454</accession>
    <name>F7K454_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44833.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359858.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00645"/>
    <dbReference type="EnsemblBacteria" id="EGN44833">
        <property type="protein sequence ID" value="EGN44833"/>
        <property type="gene ID" value="HMPREF0994_00645"/>
    </dbReference>
    <dbReference type="GeneID" id="29724131"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356617" evidence="2">
        <location>
            <begin position="30"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44833.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="429" mass="46507" checksum="BF7E662757AED3BA" modified="2013-09-18" version="2">MNIKKKLSAAVLIISVFAAALAGCGGAKPAEEAAAPTAAKQEEMTAENKEGTGGKIVFAYWGAESENNAIQTAVNAFRASHPEIEVETQWIESDYLTKVQTQIAGETTADVYLISAGDLPGFASNFDTQTVDASKYLSENVIEALQSEGELKARPFIIKPKVMAVNKDLLKAGGVEMPALDTPMTVDEFKTAIAALSDPNADPQRFGSESPWMGNLIYAFGGSYYKNNGTESNLDSQEVIAAADFVIDAREKGYVPDSIQAQGQSMMDWFLSGRIVFYTDFGPWYIPQMEEVSFDWELLPYFGNGGNKEVDGLAICSASNNKEAAEVFVTYMCEDESAQKAIGGDSSAYGVPVNAEAVTAFENIYPEKNMYAYVYAAYNQTPQETQKRTNEISSVMSRVDDETGVGTGTDKPEDVFPDIAAEINEILQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4E6</accession>
    <name>F7K4E6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250674.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00725"/>
    <dbReference type="EnsemblBacteria" id="EGN44074">
        <property type="protein sequence ID" value="EGN44074"/>
        <property type="gene ID" value="HMPREF0994_00725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.787"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363497" evidence="2">
        <location>
            <begin position="25"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="358" mass="39010" checksum="3469884EEF0E7C03" modified="2011-09-21" version="1">MKKYMFILAALLAFTGLIACGSSADNTAASPSAPSSGEDFSEASSAMVTTDAQSVPEKHLNIVTTIFPEYDWVREILGDNAGNADLTMLLDNGVDLHSYQPTAQDILKISTCDLFIYVGGESDGWVSDALQEAANKDMKVIDLLDVLDDAIKEEEIVEGMEAGEEHGDGEDEEHEEEEGPEYDEHVWLSLRNAKVLCEAITNALTEIDPDHAADYRSNLTSYGEKLDALDAAYQSAVDSASRKTLLFGDRFPFRYLVDDYGLSYYAAFAGCSAETEASFRTITFLADKADEFGLTSVLTIESSDQKIAQTIIQNTKEKNQNILTLNSMQSVTSNDVAAGSGYLSIMESNLDVLKEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K598</accession>
    <name>F7K598_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250976.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01027"/>
    <dbReference type="EnsemblBacteria" id="EGN43000">
        <property type="protein sequence ID" value="EGN43000"/>
        <property type="gene ID" value="HMPREF0994_01027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376298_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="1"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="609"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="729" mass="81981" checksum="F59734B95EF5469F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5F7</accession>
    <name>F7K5F7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01086</name>
        <name evidence="2" type="ORF">HMPREF0994_07163</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42848.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256619.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01086"/>
    <dbReference type="EnsemblBacteria" id="EGN42848">
        <property type="protein sequence ID" value="EGN42848"/>
        <property type="gene ID" value="HMPREF0994_01086"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05167">
        <property type="protein sequence ID" value="EPC05167"/>
        <property type="gene ID" value="HMPREF0994_07163"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50327S0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201795_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42848.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="72" mass="8502" checksum="763EE47F09359ED7" modified="2013-09-18" version="2">MTHDAATAYACVAYRVMEYDREPLTEEQFEVVLEMLYGFYNEREIEKIYQQNIVFGSNDAIINEEKIKGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5J0</accession>
    <name>F7K5J0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division topological specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">minE</name>
        <name evidence="4" type="ORF">HMPREF0994_01119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MinE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251068.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01119"/>
    <dbReference type="EnsemblBacteria" id="EGN42881">
        <property type="protein sequence ID" value="EGN42881"/>
        <property type="gene ID" value="HMPREF0994_01119"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1228"/>
    <dbReference type="eggNOG" id="COG0851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137929_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00262">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="91" mass="10202" checksum="525967358F7A6D9B" modified="2011-09-21" version="1">MGLMDLFRKKSSGDIAKDRLKLLLVSDRASCSPEIMEQIKNDIIEVISKYMDIDPQGLDIQITETESESGNGVVPALFANIPIKDLRHRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5K0</accession>
    <name>F7K5K0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251078.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01129"/>
    <dbReference type="EnsemblBacteria" id="EGN42891">
        <property type="protein sequence ID" value="EGN42891"/>
        <property type="gene ID" value="HMPREF0994_01129"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1239"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="435" mass="50575" checksum="1BC911188F3EF3C0" modified="2011-09-21" version="1">MYQFNREEYDKRMEWYRDARFGMFIHWGLYSIPARGEWIRSTEEMTKEEYQKYFEEFDARDFNPKEWARMAKEAGMKYMVLTAKHHDGFCLFDSKYTEYKATNTKAGRDLVREYVDAVRGEGLKVGLYFTLLDWYHEDYPHYQDRNHPMRNHPECGNENRDFSRYVDYMHKQVEEICTNYGQLDLLWFDFSYDDMRGEKWGATKLINMVRSLQPQVIIDNRLEVSGEGRGSLAECNPTPYHGDFVSPEQIIPPEGLADIEGNPLAWEACVTMNNHWGYCGTDQYYKPAPMLIKKLVECVSKGGNMLLNVGPDAYGNFPPQSVQILAEIGRWMKKNKESIYGCGIADVPKPDYGRVTRKGNTYYFHMYENTIGPVPLIGLDKTKVKGIRALADGYELPVSTSWVHIDYPDIVFADLGPNPVLPDSTDYVLKVEMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5V2</accession>
    <name>F7K5V2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251180.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01231"/>
    <dbReference type="EnsemblBacteria" id="EGN42478">
        <property type="protein sequence ID" value="EGN42478"/>
        <property type="gene ID" value="HMPREF0994_01231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890556_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="124"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="34969" checksum="DFF972C89A8A7AC6" modified="2011-09-21" version="1">MKYEYTYAELKNEMSILENTFSIVRLVDPIICRVVHVTLQNDKLIFSPTSPCYQVWNRSQQCANCISARTLRSGQACTKFECIENQVFQIICRYILLENTKLILEMGTDITAFVLDSRKTKEEIQEGIRDLNHKMVTDPVTQAYRPHYIEEHLLHTAMNTGNNPYSFHLALIGIDGLEEIRKNSGHLACDGILRAAADSIRKYLPGEDTGAFLALYNEDTFLFAAGSDTHEELKEKLLKVIHNAPAVPILFGEKPLSLQLCAGLITCTSPELIQKDMLINTLDSLREKAGQLPLRLADRIIRPAQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5X8</accession>
    <name>F7K5X8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251206.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01257"/>
    <dbReference type="EnsemblBacteria" id="EGN42370">
        <property type="protein sequence ID" value="EGN42370"/>
        <property type="gene ID" value="HMPREF0994_01257"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1374"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="413" mass="45594" checksum="8076B6362FB8E4AD" modified="2011-09-21" version="1">MGEQTNQVQLKNFNRRTVLNYIRKNKTATKAGLATATGLTFMAIKKILEELEGLHLIRCDEMEAGGMGRRAVTYAVNETYRYTVGIHINKFVTSIALMDLRGEILEVERCSMQQEFPNQNAFVELLVSEIEKVIKKSGIEKEKLLGIGVGVPGPVDTENGIILTPPNIPMLSYLPLKEILEQKCGYSVYVQKDTNVIAFGEYWYGDGSGRNNRNDCYDLAYVDVDMGIGSGLIIDGKLNIGANSIAGEFGHITIDINGPLCNCGNRGCLEAMSSGIAVLRELKAQLEKEPEHPLYEKRENLVIEDVFKMAEKKDLLTISILNQSALYVGVAISNLINILDPQIIILGGILIQKYPRYFDIVTNVANSRKVKGAKENYIAVSKLGENAGVIGAGEIVADNFFNEKVNELFCKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6B0</accession>
    <name>F7K6B0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01398"/>
    <dbReference type="EnsemblBacteria" id="EGN42260">
        <property type="protein sequence ID" value="EGN42260"/>
        <property type="gene ID" value="HMPREF0994_01398"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1520"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="194"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="376" mass="42369" checksum="CCE618595108A1CB" modified="2011-09-21" version="1">MNRKQDETIPSEKIHIALFISALRKGGSERVLVNLAEYLKNQGVQVTVVTQYKGKGEYELSPDIKRVFSEITEEETSRSRAVNFVRRFRKLRRIWKEEKPDVILSFIGKNNLMALLTSSFLNIPVVISVRGEPQAEYASGLMRFLARTYFAKAAGVVLQTKEAFSFFPDRIRKKAVILKNPLNPSFIRERFEGERELCIHAVGRMDANKNHEMILRAFSGLAEDFPGARLVIYGNGECREPLLKLAGQIGLADRVSLPGAVTDVADKIYKSSAFVLSSFSEGMPNTLIEAMCLGLPVISTDCPCGGPAELIQDGVNGYLIPPGDTDALERKLRILLSDREKADEMGRNAARLLEEYLPEHVDREWMEYLISRRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6C9</accession>
    <name>F7K6C9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM additional 4Fe4S-binding SPASM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251317.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01368"/>
    <dbReference type="EnsemblBacteria" id="EGN42230">
        <property type="protein sequence ID" value="EGN42230"/>
        <property type="gene ID" value="HMPREF0994_01368"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1488"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SPASM" evidence="6">
        <location>
            <begin position="234"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="338" mass="39427" checksum="2CD636A38781E598" modified="2011-09-21" version="1">MSRRTLYGTVIVTYRCNAHCNMCDCFRDPTRPEEEITLDDIKKLPEMAFTNITGGEPFIRKDIPEIVRELYKKSDRIVVSTNGYFTDRIIALCEEFPKIGIRISIEGMQQTNDAIRGIPDGFNRGYGTLKKLVEMGHPDVGFGMTVQDMNCEDLLPLYDISNQLGMEFATATLHNSFYFRKTDNKIDNKYKVAQNFEKLINELLKSKSPKKWFRAYFNHGLINYIYGNERLLPCNMSQNAFFIDPFCDVIPCNGMEKKAVMGNLHEQSWEELWNSEQAEKVRECTRKCDRNCWMIGSASPAMHKYIWVPGWWVIKHKFFKGGRYSLSENRFISREKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6I8</accession>
    <name>F7K6I8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UvrABC system protein A</fullName>
            <shortName evidence="14">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uvrA</name>
        <name evidence="17" type="ORF">HMPREF0994_01496</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01496"/>
    <dbReference type="EnsemblBacteria" id="EGN41970">
        <property type="protein sequence ID" value="EGN41970"/>
        <property type="gene ID" value="HMPREF0994_01496"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1632"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="602"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="741"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="642"/>
            <end position="649"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGN41970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="953" mass="105534" checksum="B754A67BBECF116D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6M8</accession>
    <name>F7K6M8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251487.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01538"/>
    <dbReference type="EnsemblBacteria" id="EGN42012">
        <property type="protein sequence ID" value="EGN42012"/>
        <property type="gene ID" value="HMPREF0994_01538"/>
    </dbReference>
    <dbReference type="GeneID" id="29726848"/>
    <dbReference type="eggNOG" id="ENOG5033VP6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1822066_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="137" mass="16120" checksum="D75EF42B7E4EF292" modified="2011-09-21" version="1">MKDIISIRIPSICICFTLVTVANSALNLLHSGGTDMYSVSILLIFVWLVLCQLIDAAICRIDFKKWIHYCITESLILYLATLVFCRVFYWHSFTVRQLIMYTVVFAFVDIFIFSYFRKRQEMRADEINRLLNKKDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6N2</accession>
    <name>F7K6N2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251491.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01542"/>
    <dbReference type="EnsemblBacteria" id="EGN42016">
        <property type="protein sequence ID" value="EGN42016"/>
        <property type="gene ID" value="HMPREF0994_01542"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1682"/>
    <dbReference type="eggNOG" id="COG4667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048271_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07208">
        <property type="entry name" value="Pat_hypo_Ecoli_yjju_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037483">
        <property type="entry name" value="YjjU-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="32064" checksum="6BCCCCC17466CE30" modified="2011-09-21" version="1">MYQAGLVLEGGGMKGVYTSGVLDFFLDKDIEFSNCYGVSAGACNLCSYLSRQRGRAYAVSVDYLDDKHYCSAYNVLTTGDLFGVKMCYDDIPNRLNPYDYEAFNAYKGKAYAVVTNIETGQPEYLRLKEMNRDIIAVRASASLPLVSRNVKIGDKLYLDGGLSDSVPIMHSIVDGNRKNVVVLTKEVGYRRQPASHLGIMKLRYARYPKIYELMANRHIAYNNMLDYLDAQVANGQAFVIRPKKASGIGRIEKDKEKLRMLYEEGYQDARDCYDDLMHYLENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7K700</accession>
    <name>F7K700_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN42056">
        <property type="protein sequence ID" value="EGN42056"/>
        <property type="gene ID" value="HMPREF0994_01582"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2825594_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363775" evidence="2">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="66" mass="7142" checksum="F3E39419E60D5FC3" modified="2011-09-21" version="1">MKNRAGKLIGILLLVMGLFLAAGCGSKAGESETQETEAQQERVTKHYGQGHKRQTTKRGLLTTNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K716</accession>
    <name>F7K716_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01423"/>
    <dbReference type="EnsemblBacteria" id="EGN41897">
        <property type="protein sequence ID" value="EGN41897"/>
        <property type="gene ID" value="HMPREF0994_01423"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1551"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_34_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="145" mass="16521" checksum="DC1F50AB1957535D" modified="2011-09-21" version="1">MVIREVKEWELQELLSLYLFLHEKALPEDMEPLSSAWEQIMADPNHHIIVAEEEGKLVSSCVCVIIPNLTRKGRPYAFIENVVTHSDYRKRGLAAACLDYAKSMAEAAGCYKMMLLTGAKDEGTLEFYKKAGYNCKDKTAFIQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7K726</accession>
    <name>F7K726_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsH</name>
        <name evidence="11" type="ORF">HMPREF0994_01655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01655"/>
    <dbReference type="EnsemblBacteria" id="EGN41772">
        <property type="protein sequence ID" value="EGN41772"/>
        <property type="gene ID" value="HMPREF0994_01655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1808"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="232"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="639"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="709"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="240"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="824" mass="89373" checksum="1F4AFB79F15E806D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K783</accession>
    <name>F7K783_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251625.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01712"/>
    <dbReference type="EnsemblBacteria" id="EGN41694">
        <property type="protein sequence ID" value="EGN41694"/>
        <property type="gene ID" value="HMPREF0994_01712"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1871"/>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764481_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="375" mass="44216" checksum="F60783FA4C390D0B" modified="2011-09-21" version="1">MKRRWTEEEAWAWYTARPWISGFNFIPSGSMTGSLWLFQEYGHKEAFRDAAREIALAAELGFNSIRMVLPFEVYRQEKEAFFRHMDEFLELLGEYDITLMPVLFGDCCVPREKYRTPRLGPQPEPVPGYFGGSPVTPFDDSTQSGESIGYSITDDPENRPVIEEYIKELASRYGQDPRILMWNVWNEAGNSGRLSRSLPMMEVVFTWLREANVMQPLTADVWGAGADNPYGWLKKPGIYAEIEEHSIALSDIITFHYYGDYTHSRQYVEFLRRFNRPLINTEWLHRPFRSLIQTHLPMWKKEGVGSYFFGFVNGKSQFNYVWEFIKKLPDIDTSLWMHDIFHEDFRPYDREEIEVIRECNRDKTLPENIGRMKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K794</accession>
    <name>F7K794_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251636.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01723"/>
    <dbReference type="EnsemblBacteria" id="EGN41666">
        <property type="protein sequence ID" value="EGN41666"/>
        <property type="gene ID" value="HMPREF0994_01723"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1881"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="31396" checksum="D484A13B9AEE17E8" modified="2011-09-21" version="1">MTRARKQTLVKIISYILLIILTAATLMPLLWMLSASLKTNTEVFSANFRWIPAVFQWNNYVKIWSKIPLATFTFNTVKLTVIITFIQVITSSFAAYGFSKCKFKGRDVLFLCYVATIAIPWQVYMLPQYSMMNKFHLVDTHTGYVLMQSFTAFGVFLMRQFFMSLPNELLEAGRIDGLSEYGNYFRIALPLSKPSIATMTIFSFVAIWNDYMGPLIYFNSTSKKTIQLGIKMFIGQYSTEYGLVMAASVLSLIPVLIIFLGGQKFFVQGIASSGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7H4</accession>
    <name>F7K7H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01803"/>
    <dbReference type="EnsemblBacteria" id="EGN41616">
        <property type="protein sequence ID" value="EGN41616"/>
        <property type="gene ID" value="HMPREF0994_01803"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1968"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="338" mass="37511" checksum="8BED22F6831C79EA" modified="2011-09-21" version="1">MDAILQVENLTTSFLTSNGEVQAVRGVSFSVGKGEILGIVGESGSGKSVTSMSILRLLADTARIKDGSILFEGEDLTKVSKKKLREIRGNKISMIFQDPMSSLNPLIPVGKQVSEMIKIHHPKMGKEERKAQVMELFAKVRIPEPEKRYHSFPHEFSGGMRQRVMIAMALANKPELLIADEPTTALDVTIQDQILRQLRELDKEYGASIIFITHDLGVVAELCDRVLVMYGGLIMEEARIEDIFERPGHPYTMGLLHSIPDVEQEKSERLEPIPGSPPDMTNPPAGCPFAPRCSYARKVCAGSLPDFVEVGEGHRTRCFLQYEDAPADEHNPFRGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7J3</accession>
    <name>F7K7J3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Streptomycin 3'-adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63228"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:146260"/>
            <dbReference type="ChEBI" id="CHEBI:146261"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251735.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01822"/>
    <dbReference type="EnsemblBacteria" id="EGN41635">
        <property type="protein sequence ID" value="EGN41635"/>
        <property type="gene ID" value="HMPREF0994_01822"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1993"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071584_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024172">
        <property type="entry name" value="AadA/Aad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025184">
        <property type="entry name" value="DUF4111"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13427">
        <property type="entry name" value="DUF4111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000819">
        <property type="entry name" value="Streptomycin_3-adenylyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="4">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4111" evidence="5">
        <location>
            <begin position="147"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="29058" checksum="2E9E15D01E8A7726" modified="2011-09-21" version="1">MEYQFMLDKIVETSKDIIGEELTGIYLHGSLAMGCFHPDKSDIDLILVIKNSVSDGQKRRLMDILVELNETGPRKGIEFSMVTEEACRSREYPTPFELHFSPAHLAWYRSDPEDYIKKMKGTDPDLSAHFMIIRHYGIVLYGRPVEEVFDEVPREFYLKSICSDIESSGEEILENPLYVILNLCRVLGYAEEGLILSKKTGGEWGLANVPAAFAPLLREALECYASDREMKPDAEEAESFNKYMRQRIKERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Z2</accession>
    <name>F7K7Z2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251952.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02039"/>
    <dbReference type="EnsemblBacteria" id="EGN41444">
        <property type="protein sequence ID" value="EGN41444"/>
        <property type="gene ID" value="HMPREF0994_02039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_11_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="56" mass="5513" checksum="58FC280D7B3C88F5" modified="2011-09-21" version="1">MAYVINDSCVSCGTCEGQCPVGAISAGDSQYVIDADTCISCGSCAGVCPTGAISEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8S9</accession>
    <name>F7K8S9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252179.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41185">
        <property type="protein sequence ID" value="EGN41185"/>
        <property type="gene ID" value="HMPREF0994_02278"/>
    </dbReference>
    <dbReference type="GeneID" id="29726510"/>
    <dbReference type="HOGENOM" id="CLU_1370676_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="199" mass="21077" checksum="C2E3DFF5CB5EF35C" modified="2011-09-21" version="1">MKVQNNIVLNSDLGGFSFKEEAGIKYVRGADSVWVPFSSIAYIANFKGKYGTGNNSVISATPEEIQGYKLALYGFTNLYASGAMHVAAISADNNHVQAGSQYGSVISATYGGYFVKTGTPYIIKEHSLVKTSTVNLSNNVPGYRLVGGVLHFSDYSSSQTGGAAIGNLAMDNSSDIIIANVLFQYSAVTVSAKLLYLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9A3</accession>
    <name>F7K9A3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252351.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02450"/>
    <dbReference type="EnsemblBacteria" id="EGN40849">
        <property type="protein sequence ID" value="EGN40849"/>
        <property type="gene ID" value="HMPREF0994_02450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2684"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="179" mass="20106" checksum="A85EC5A01B93F9D1" modified="2011-09-21" version="1">MNIGNKLKELRVQKGLTQEELADRAELSKGFISQLERDLTSPSIATLVDILQVLGTDLNEFFSEKTEEQIVFSSSDYFEKTDEACRNRTEWIIPNAQKNIMEPIRLTLEPGGSTYPDNPHEGEEFGYILSGSVTIHIGKRAIRAKKGESFYFTPNSTHYLTANEKTGASLIWVSSPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9A7</accession>
    <name>F7K9A7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02455"/>
    <dbReference type="EnsemblBacteria" id="EGN40854">
        <property type="protein sequence ID" value="EGN40854"/>
        <property type="gene ID" value="HMPREF0994_02455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2689"/>
    <dbReference type="eggNOG" id="COG3274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061343_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="13"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="44091" checksum="0CBF3E825E406AE9" modified="2011-09-21" version="1">MEEQKKMGKKRMANVELLRICSMLMIVLMHLLNHGKVLETVEKGSVSYYLTWTIFGISFVSISCYILISGYFLCEASFSFVRLLRLEGQVWFYSAALFIAAAVVLRQPLDMSSLIAAVFPILSCEYWFVTMYAGMLILSPFLNKLLLGLSRKQFRLLLGFLFVLFSLWPNVFFFSPALNFGGGSGVVWFVTVYLFGAYLKRFYVPDGRTARHFLHFLAAGLLIPASRFVIELLLATPLGKIGFLQDLMWGYSLFYQYNSVLVLAAALLLFIAFLNLEIRPGRLQRLILAAAPLSFGVYLLHDNPNWRGILWEWINPSQMADKWYLVPGVLTLAAGIFLVCALLEMLRKTAAGLPGRLRRNKEGGRKQGWLERKALKLDEKLLRENEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9L9</accession>
    <name>F7K9L9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252304.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02403"/>
    <dbReference type="EnsemblBacteria" id="EGN40802">
        <property type="protein sequence ID" value="EGN40802"/>
        <property type="gene ID" value="HMPREF0994_02403"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2632"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="222" mass="25218" checksum="7EF0415236D3E608" modified="2011-09-21" version="1">MKYRIMVIEDDPVIREELCILLKGNGYEVGAVTDFTDTLEQIREWQPHLLLLDINLPGEDGFRICSGIRTFSAAPIIFVTSRNTDMDELNSIMLGGDAFITKPYNVAILLARIASLLKRACPSGEAEVLEHRGLCLYPESGRMAFEGKQAELTKNEMKILIFLFRHAGSICPRADIVEYLWDNRLYVDDNALSVNISRIREKLAELGLPDFIRTKHRQGYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9P1</accession>
    <name>F7K9P1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252456.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02555"/>
    <dbReference type="EnsemblBacteria" id="EGN40954">
        <property type="protein sequence ID" value="EGN40954"/>
        <property type="gene ID" value="HMPREF0994_02555"/>
    </dbReference>
    <dbReference type="GeneID" id="29725221"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2799"/>
    <dbReference type="eggNOG" id="ENOG5030HJC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945638_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="298" mass="34528" checksum="741208F17BBA0D93" modified="2011-09-21" version="1">MKNYTIAEQFAVIALNAQDSLHESVAKNVALVGIAAAKTVQTLLYEENRDAAVFELKLREQLDGIKKMKRKERNALEKEFTDILKAERILKEIPNLLGCDMNYYTANVTMREYKSDSALYQSIIKKIRTCALEQTELPEDIVILLWLFRESGCMHDIFSQEEQEKVRIKLVQAAEEKSLYKAILEQEFHSAVWLLGLKFMNWKHKIFTNPYLEGVNLMFPFLDRRQAIFIDMVIMGTSVKDRRSAAIAFLEKNGHTCEKIKNGTETIVKVDNEYYRIFPSTRSFKIPIQGVELLPVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9T7</accession>
    <name>F7K9T7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252521.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02620"/>
    <dbReference type="EnsemblBacteria" id="EGN40603">
        <property type="protein sequence ID" value="EGN40603"/>
        <property type="gene ID" value="HMPREF0994_02620"/>
    </dbReference>
    <dbReference type="GeneID" id="29724628"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2872"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="35061" checksum="7448E71C9A5E6A99" modified="2011-09-21" version="1">MEENMFTNPVLDGCADPDVIYYEGTYYLYATNTDMKDDSEMGFKVYTSKDLIRWHDAGMALKACDSWGEKQFWAPDIIYTNGLFYLSYSVEEHLCIATSRSPLGPFVQEVKKPLHEDTKEIDSHFFQDADGTWYLYFVRFFDSNQIWGAKMTDDLLGIREETLTRLLVPDTPWECIQWPVNEAPYMLLHKGLYYLTYSGSHCLSDYGSGYAVSDSPLGGFRKYENNPILRSNENVHGVGHHCITWSPDKKDMFIIYHQHYDLTKMGPRRLCVDRIRFEEQDNGPDILVVDGPVTTTQPCFFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9V4</accession>
    <name>F7K9V4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02637"/>
    <dbReference type="EnsemblBacteria" id="EGN40620">
        <property type="protein sequence ID" value="EGN40620"/>
        <property type="gene ID" value="HMPREF0994_02637"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2892"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="325" mass="36491" checksum="94CDA82DE7D7E889" modified="2011-09-21" version="1">MKVLVTGGAGFIGSHLVDRLLEENNDVIVADKLIFGDKNIKHLVGNKRLLKSGRFKYYQVECANQNNVDRLFKENKIDAVYHMAANSDIQKGGRDPKIDFNDTFLTTHALLEGMRNANVKNLFFASTSAVYGEMLDVELTETTGGIKPVSYYGGTKLASEALISSYVSMCDMNVVIFRFPNVIGPRLTHGVIFDFIKKLQKYPNELEILGDGMQCKPYIYVLDLVDAITKLTKEWHPGEEVYNISVKGKGSTVTHIAEIIVEVLGLQDVLFKYTGNDRGWKGDVPRFKYNISKILATGWEPKYTSDEAVKQTVIDVLKEVKYKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA21</accession>
    <name>F7KA21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252605.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02704"/>
    <dbReference type="EnsemblBacteria" id="EGN40687">
        <property type="protein sequence ID" value="EGN40687"/>
        <property type="gene ID" value="HMPREF0994_02704"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2959"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="334" mass="35237" checksum="0F002EBB23F4051C" modified="2011-09-21" version="1">MTESGRKLRTSAVIAILAALLAAGIWMDINAGYRKISPEELWQIILGGGEKSLRYTLLNLRLPRVLTSLLVGTGLAVSGCVIQGVSRNEMAEPGILGVNAGAGLFIAAFMVFLPQSGLKLTLLLPVLAFAGSLAAAALDYRLALTRQGLSPKRLLLIGIAMSTIISSLTTMLMLRMSDSEYAFVQNWLAGSIWGASWPNVRLLSLGLTALILFVFYKSRTLNVLALGHQTATGLGVDVSRQSAILLGAAIAMSSLCCAVGGGLSFVGLVCPHLARRLAGPDYRVLLPATVLSGAVLMTFSDILSRTLLAPNEIPVGIVAAVIGAPYFLYLLIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA23</accession>
    <name>F7KA23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02706"/>
    <dbReference type="EnsemblBacteria" id="EGN40689">
        <property type="protein sequence ID" value="EGN40689"/>
        <property type="gene ID" value="HMPREF0994_02706"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2962"/>
    <dbReference type="eggNOG" id="ENOG5032WAW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150712_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="26844" checksum="32530CB6E6A9DC6F" modified="2011-09-21" version="1">MMRRIIKSAIHKNRLAGLLYDNYSLRTVVFAYGALGVNAYLALTKGAAGWYFGSDWLSTLAMYYLLLCVIRFTLLRASRKVTALTDQDARMRKEWKACRVCGEVFMGMTVILMGIVVLITAEGFTFAYDGLLIYAVAAYDFFCLTKAIIYMGKNRKNHTPLIVAIKSVNLAAALVSILSLQTAMFAAFGSDMETVVQTRMNLATGAAVCMMIFLFGFFMAVHSKKQMKALITGKTNREAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA40</accession>
    <name>F7KA40_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">era</name>
        <name evidence="13" type="ORF">HMPREF0994_02724</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9 10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02724"/>
    <dbReference type="EnsemblBacteria" id="EGN40707">
        <property type="protein sequence ID" value="EGN40707"/>
        <property type="gene ID" value="HMPREF0994_02724"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2980"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="12">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="216"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="9">
        <location>
            <begin position="52"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="9">
        <location>
            <begin position="73"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="9">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="9">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="73"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN40707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="312" mass="35193" checksum="E8B7BF07F6B35515" modified="2011-09-21" version="1">MDLEELLAAGRPLNEKYKSGFATLIGRPNVGKSTLMNRLVGQKISITSNKPQTTRNRIQAVYTSEEGQIVFLDTPGINRAKNKLGNYMLKAAEGTLRDVDVILWLVEPTTYIGAGERYIIEQLKKTKTPVILVINKTDTVKKDDVFPAIDTYRKELDFAEVVPVSARCGTNTDTLISCILKYLPYGQPFYDEDTVTDQPERQIVAELIREKALRSLDEEIPHGIAVAIESMKYRKNIADIEATIICEKDSHKGIIIGKGGQMLKTIGSKARPEIEDMLQCKVNLQLWVKVKKDWRDSDFLLKNFGYNPKDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA47</accession>
    <name>F7KA47_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252633.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02732"/>
    <dbReference type="EnsemblBacteria" id="EGN40715">
        <property type="protein sequence ID" value="EGN40715"/>
        <property type="gene ID" value="HMPREF0994_02732"/>
    </dbReference>
    <dbReference type="GeneID" id="29725588"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2989"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436615_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="468"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="635" mass="73115" checksum="ED9C0402BC98F0AB" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA58</accession>
    <name>F7KA58_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02744"/>
    <dbReference type="EnsemblBacteria" id="EGN40727">
        <property type="protein sequence ID" value="EGN40727"/>
        <property type="gene ID" value="HMPREF0994_02744"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3002"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="291" mass="32030" checksum="96EE107C19041CA5" modified="2011-09-21" version="1">MQNYCITTDSNSDLPSSYKEKFGTTIIPQYYAFGDEVYGDEKNMPPAEFYERMKQGELPSSMANNPAVIREKFEQILEKGMDILHIAFSSALSGSYNNVYVTAQELCEEYPDRKIIVLDSLNVSLAETILVIKANHFLEKGKTLEENAALLEEYKKHLHVQFTVDDLFHLKRGGRISGAVAAVGTALNLKPFLYVGTNGNLVSDGTSRGRKKSIRTLAERMKNTLGDAPDKTVPVGIVHGNCPEDARMAADFVTELTGITDIIINDISPSIGTHAGPGALGILYYGEEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA94</accession>
    <name>F7KA94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02944"/>
    <dbReference type="EnsemblBacteria" id="EGN40553">
        <property type="protein sequence ID" value="EGN40553"/>
        <property type="gene ID" value="HMPREF0994_02944"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030IZH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2233053_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="105" mass="11798" checksum="CB7316354E3DCDE4" modified="2011-09-21" version="1">MTGFTYWIGLFFPADAAVPEGYASIDLPESNIGVGWVCGKEENGEIYGDAHGEVCKKLDEDGFNSFRNDITGENTYCFFERYHSLRFTQKDANGNVTLDYGNYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAJ0</accession>
    <name>F7KAJ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252717.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02816"/>
    <dbReference type="EnsemblBacteria" id="EGN40425">
        <property type="protein sequence ID" value="EGN40425"/>
        <property type="gene ID" value="HMPREF0994_02816"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3083"/>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="193" mass="22002" checksum="7143D666C172BEFF" modified="2011-09-21" version="1">MRLLRMKKIHEGSYLNNYELTYLNKGGREKVFELVSRSRLSCAGDIGRQVNGVTIVAFQDDRLLLLKEFRMSINKSIYNLCAGMIQDGESVEECARRELYEETGLSVSRFLDILPPSYSAVGFSDTSTYLVIVQTEGSFSDHTSENEEIKAGLYSREEIREMLKTEEFSSRSQTVAYFFANGFSLPGLHKEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAR7</accession>
    <name>F7KAR7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40502.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02893"/>
    <dbReference type="EnsemblBacteria" id="EGN40502">
        <property type="protein sequence ID" value="EGN40502"/>
        <property type="gene ID" value="HMPREF0994_02893"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="383"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40502.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="551" mass="59750" checksum="14207EFFA7450844" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB36</accession>
    <name>F7KB36_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252966.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03065"/>
    <dbReference type="EnsemblBacteria" id="EGN40242">
        <property type="protein sequence ID" value="EGN40242"/>
        <property type="gene ID" value="HMPREF0994_03065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3350"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="14717" checksum="36E1264FD30D730F" modified="2011-09-21" version="1">MTIAEVSKKYEMSPDTLRYYERIGLIPQVPRNKSGIRDYDENSCRWIELMKCMRKAGVQIEALIEYVSLFQQGDSTVNARKMLLIEQRDQLLARMEEMQKSLDRLNQKIDRYEQGLMQAEKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB92</accession>
    <name>F7KB92_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopentomutase</fullName>
            <ecNumber evidence="4">5.4.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyribomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoB</name>
        <name evidence="6" type="ORF">HMPREF0994_03121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphotransfer between the C1 and C5 carbon atoms of pentose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27658"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 or 2 manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphopentomutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253022.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03121"/>
    <dbReference type="EnsemblBacteria" id="EGN39951">
        <property type="protein sequence ID" value="EGN39951"/>
        <property type="gene ID" value="HMPREF0994_03121"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3412"/>
    <dbReference type="eggNOG" id="COG1015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053861_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00740">
        <property type="entry name" value="Phosphopentomut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01696">
        <property type="entry name" value="deoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="2"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="385" mass="42716" checksum="3CF67B9054B24DDB" modified="2011-09-21" version="1">MKRIFLIVLDSVGIGAEPDAPEYGDAGTNTLKSASTSSFFHMPNMEKLGLFNIEGIDYHPSCEAPMASVARMQEASKGKDTTIGHWEIAGIYSGRPLPTYPNGFPSEVLDEFTRLTGRGVLCNKPYSGTDVIRDYGDEHLRTGALIVYTSADSVFQIAAHEDIVPPETLYEYCRIARKILVGEHGVGRVIARPFTGTAGNYTRTSGRHDFSIEPPSVDMLDQLKENGCAVIGVGKIHDIFAGKGLTEYVYTQGNEDGINKTLDYMDKEFRGLCFINLVDYDMLYGHRNDIDGYAKALTYFDQRLPELLARLKDEDLLMITADHGCDPGYTVSTDHSREYTPFLLYGRNIPPVNWGTRDTFADIGATVLDYFGITPQFKGKSMLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBD1</accession>
    <name>F7KBD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Osmoprotectant transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253063.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03162"/>
    <dbReference type="EnsemblBacteria" id="EGN39992">
        <property type="protein sequence ID" value="EGN39992"/>
        <property type="gene ID" value="HMPREF0994_03162"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3454"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="26885" checksum="71F36848750A30EE" modified="2011-09-21" version="1">MSIISLTDITASYGSKGVLKHFSLDIGQGEFVMLIGTSGCGKTTALKLMNGLLKPDAGRVVVNGKDLADTDLTALRRKLGYVVQETGLFPHLTIEKNISYVADLYGKRDKKAVRERVSQLLALVELPEEVRRRYPDELSGGQKQRVGIARALMNSPEIMLMDEPFGAVDEITRRRLQEEIGRIHRQQKETIVFVTHDIDEALRLGTRIVVMDEGKIIQDGTPQEIRANPATDFVKKLISDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBL5</accession>
    <name>F7KBL5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253153.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03252"/>
    <dbReference type="EnsemblBacteria" id="EGN40082">
        <property type="protein sequence ID" value="EGN40082"/>
        <property type="gene ID" value="HMPREF0994_03252"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091228_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="222" mass="25557" checksum="ED452ED2C72C5AB2" modified="2011-09-21" version="1">MVQSKGWDWENANQSAWLKPTEDSYYLSQVWKEKGYSKLLDLGTGMGRHAVHFAKNGFDVSAVDISDYGIRHLISWAENEKLPIKAVTGDMLHLPYPDKEFDCVFAYHVVSHSDTQGVEMIISEIERVLKRDGEIFLSFCSKESTDFQEAQADRIDGNTVIYQKEPEVGVPHFYADLADIIKLLHNFSIIKVRHTEYCSLDLHNRHKRMYYYVNAVYSPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBN1</accession>
    <name>F7KBN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ech hydrogenase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253169.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03268"/>
    <dbReference type="EnsemblBacteria" id="EGN40098">
        <property type="protein sequence ID" value="EGN40098"/>
        <property type="gene ID" value="HMPREF0994_03268"/>
    </dbReference>
    <dbReference type="GeneID" id="29728391"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3569"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145298_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="112" mass="12998" checksum="991F3C67DEA03AA9" modified="2011-09-21" version="1">MIDGEIMQVEPENLVTEVLMLKHRDYRIIQICAAKAGDRIEITYSFGKEYKMVGLRISILPDTEIVSISDIYAPAFLYENEIHDLFGINIKMISLDYHGNLYRIKKEAPFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCQ2</accession>
    <name>F7KCQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03631"/>
    <dbReference type="EnsemblBacteria" id="EGN39003">
        <property type="protein sequence ID" value="EGN39003"/>
        <property type="gene ID" value="HMPREF0994_03631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN39003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="34128" checksum="7C5F6D0FEFD331DC" modified="2011-09-21" version="1">MMKKSDHIQNGEKEMADIQNLTKLLADAREKGYAVGSFSARYTKLIRPIIQAAINTNSPVIVQLSEKEVIRHKVGIKEFADEFYRVAEELDPQIPLSLHLDHTKTLDVIKEALEAGFTSVMIDASEKDFDENVAVTQQVVEMAKPYHATVEAELGKIGTTDFAETDTDEELYTNPEEAAEFCRLTGVDCLAVSVGTAHGVYTVRQPKVDYERLEAINRLTDTPLVLHGGSGVPSEMVVKAAQIPTGGVSKVNIATDIELAMLAVIGREGHMTEEELNACTAEQIEKSREAVRLLVEDKIRNYLLSENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCV4</accession>
    <name>F7KCV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03683"/>
    <dbReference type="EnsemblBacteria" id="EGN38964">
        <property type="protein sequence ID" value="EGN38964"/>
        <property type="gene ID" value="HMPREF0994_03683"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4020"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="283"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="501" mass="57222" checksum="F76BD097A8E68BF4" modified="2011-09-21" version="1">MAISIQVNEKRIKGQRSPMLYGHFIEHFHRQIYNGIYDPQNPLSDEDGLRGDILSAMRQIKVPVLRWPGGCFVSSYHWKDGVGKNRQPFFDKAWRVEDPNTFGTDEYIKMCRKIGCKPYICTNAGTGTAEEMSDWVEYCNLESEGKYAKWRIENGSPRPYGVKYWSIGNENYGFWEIGAKSADEWGRLVKESAKMMKHVDPRAELSAAALSDLDWNINLLKNCGQFLDWISIHEYWDMMAEKNEPATYEQCMAYTDHIDHSVDEVRGMLAAMKLDKKIRIAFDEWNLRSWHHPNVHTVRQGTGKEDYITPRDKNDDNSMYTMADAVFTACFLSAMNRNCDIVGMANFAPILNTRGCIYSYPEGIVLRSTYHVFDLYVNYLGDIVVDLWTPDSVPCMHVTGKNGQETDVETLDLLATTWSDRPGTALAAVNKHPSDSAAIRLSTAFEGMNVVIYRLNGSSPDSYNDVNRTEVSIRKEELGMFRENMEISVEPHSVNVIQLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCX3</accession>
    <name>F7KCX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253603.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03702"/>
    <dbReference type="EnsemblBacteria" id="EGN38866">
        <property type="protein sequence ID" value="EGN38866"/>
        <property type="gene ID" value="HMPREF0994_03702"/>
    </dbReference>
    <dbReference type="GeneID" id="29728641"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4041"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363669" evidence="1">
        <location>
            <begin position="36"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="545" mass="61059" checksum="E1838BC390C069A9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCY1</accession>
    <name>F7KCY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03710"/>
    <dbReference type="EnsemblBacteria" id="EGN38874">
        <property type="protein sequence ID" value="EGN38874"/>
        <property type="gene ID" value="HMPREF0994_03710"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032UYP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643710_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="426" mass="48627" checksum="A4EE41DC9B661358" modified="2011-09-21" version="1">MMILGHVGIQSYYNKVSSASTRSALEKIAERLLTRQPPNYNQPNVDRVELSSSAKDYARMHGYGCTMQRMEFEYEYRPAEPMNIPELLPPSEVIDYTEHDALMNQYMKQYRAEEGEWMSLRIPDISDEKLENFRKELNENGLGEDIDWQGVIDDFFDIDIRLEHVERLEMKADYIASRYAVLKDRIQTQYDGDEQKAQMDKLDSIYNQAKEKMADTYAKNIGGFYEDLGQTGVIEDMRSSVLAMVDEKEAAYETFLAGAGDYANLKDSEDSWLAQDDAYLAARLRDSFAADGGNIQSGSSQAVYSGDDLTFAGVYAKSLSQQIKDAGHVWEVWRPCESDSELGKFLAKQYQDTRQIVADAGISDKLAGIIQNTFRPFMEKFMDALDGQIDKNLARVEKNPWMGGVLRLDYINRNAVYRMYLSIIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD29</accession>
    <name>F7KD29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253659.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03758"/>
    <dbReference type="EnsemblBacteria" id="EGN38823">
        <property type="protein sequence ID" value="EGN38823"/>
        <property type="gene ID" value="HMPREF0994_03758"/>
    </dbReference>
    <dbReference type="GeneID" id="29729557"/>
    <dbReference type="eggNOG" id="ENOG5030MR9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1956771_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356814" evidence="2">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="128" mass="13847" checksum="90193EAD62BB15FA" modified="2011-09-21" version="1">MKRKWMIVIGILSAISISACGGSQDTQKEKPSESQTVSEVQTTVGETGTASEETSDNAAATGEEQLYCIVNEATADSLNVSDMEGNTYTFEVKDSGLKLNDKIFVYYTGNLEDGSAQVLRIEIYEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDG7</accession>
    <name>F7KDG7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253805.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03904"/>
    <dbReference type="EnsemblBacteria" id="EGN38669">
        <property type="protein sequence ID" value="EGN38669"/>
        <property type="gene ID" value="HMPREF0994_03904"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4248"/>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764481_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN38669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="371" mass="43978" checksum="595AE0778A96E234" modified="2011-09-21" version="1">MKRKWTEEEIWKWYKNHEWISGFNFVPSTSTGGILWLLQEHDHRNAFNEAAKEIALAASLKLNSVRVFLPFYLWKEQHDSFMKNLEEFISLLDSYGMTLMPVLFNDCTVAKAFYKKPVLGIQPEPEEGFFGGSSLNSFDVDTQSGDSIGYNITDETDMEPVVEEYIRELARVYGQDDRIIIWNIWNELGNSGRDAMSMPMARKVIGWFREEDVKQPLTIEMWGAQTDGKNYYEWLHHPKIYGEVDRENIELSDIITFHFYGDYTHARQLITFLRQFNRPLINTEWMHRPFRSLIQTHLPLWKKEKIGSYFFGLVNGKTQFNIVWDFIKDYPGIDISLWMHDLYHADFTPYDAEELDVIRECNEDKIIWKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDX9</accession>
    <name>F7KDX9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253959.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04058"/>
    <dbReference type="EnsemblBacteria" id="EGN37583">
        <property type="protein sequence ID" value="EGN37583"/>
        <property type="gene ID" value="HMPREF0994_04058"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4426"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN37583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="32069" checksum="07CB1CB284D8F23B" modified="2011-09-21" version="1">MKKKKWNKSRRAFLAFLLPSFLGVVFFVLLPFLDVFKRSFTTAVTGEFVGIQNYVTVYENRAFRLAVGNTLRFTLVCLPLLLVLGLLAALLLTNMKQAQLLKSFFLLPMAMPAATIVLIWKMTFSESGFLNRLLSAHTDYMGTGLAFWVLVFSYVWKNLGYTVVLWLAGILAIPEDYIQAAKVDGAGKVRIFFSIILPQLKGCMYTITVLSFLNSFKVFRESYLVSGAYPHESMYLLQHLFNNWFVYLELDKMAAAAVCIGIVLLGVILFLEKLWEEGDEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDZ0</accession>
    <name>F7KDZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253970.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04069"/>
    <dbReference type="EnsemblBacteria" id="EGN37105">
        <property type="protein sequence ID" value="EGN37105"/>
        <property type="gene ID" value="HMPREF0994_04069"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4440"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN37105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="223" mass="25422" checksum="7018E3F71D6540C7" modified="2011-09-21" version="1">MRLLIAEDEKDLNQVITKTLQKNHYSVDSCLDGQEALDCLDMAEYDAIILDIMMPRVSGLEVLKKLRSAGNKTPVLLLTARDSVQDRVAGLDTGADDYLVKPFDFEELLARIRVMLRREGGRIDNCYRIANLKVDCDARCVFRDDIPIALSSKEFSILEYLICNQGIVLSREKIEQHIWNYDYEGGSNVVDVYIRYLRKKIDDGFTPKLIHTVRGAGYVLKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDZ7</accession>
    <name>F7KDZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chlorophyll synthesis pathway protein BchC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253977.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04076"/>
    <dbReference type="EnsemblBacteria" id="EGN37112">
        <property type="protein sequence ID" value="EGN37112"/>
        <property type="gene ID" value="HMPREF0994_04076"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4448"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="8"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN37112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="36738" checksum="110D76FD49C54A57" modified="2011-09-21" version="1">MKSAVFYGKHDLRVEEYAQPEVGPEDVLIQVKACGICGTDVHIYEGDKGAAEVTPPTILGHEVSGVVVKTGDKVTEYRAGDRVCIDPNCYCGACDACRNGEAHFCEHMIGYGTTVNGGFAEYCAVNYRQVYRLGENTTFEQGAMAEPVACCLHGLDMCEIRPGHQVVVIGGGMIGLLMVQLAKLAGAAKVALLEPVEGKREVGKKLGADICIDPVNEDVKAALAGAGMNWVQTVIECVGRPSTIEQAIEIAGKKAVVMMFGLTKPEETIAVKPFQIFQKELVLKASYINPYTQKRALDLIDSGCLDVSSMIYDVCGLDRLGDILSQPQLRAKGKYIISPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE60</accession>
    <name>F7KE60_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254040.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04139"/>
    <dbReference type="EnsemblBacteria" id="EGN36932">
        <property type="protein sequence ID" value="EGN36932"/>
        <property type="gene ID" value="HMPREF0994_04139"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4511"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123330_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="149" mass="17508" checksum="B60F739924135CC3" modified="2011-09-21" version="1">MCGVCQTIQETIEGKNRYFVRELETGYVVIGDYQRIKGYTLFLCKVHATEIHFLERPFRETFLNEMSLVAEAVYNAFGPDKLNYELLGQGENVHMHWHIFPRRKGDTPVPGPVWKLPREEMYAEQYLPSDEELQELKQKLNAELDKLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEK3</accession>
    <name>F7KEK3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254183.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04282"/>
    <dbReference type="EnsemblBacteria" id="EGN36094">
        <property type="protein sequence ID" value="EGN36094"/>
        <property type="gene ID" value="HMPREF0994_04282"/>
    </dbReference>
    <dbReference type="GeneID" id="29724403"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4677"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044992_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="316"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="456" mass="52338" checksum="AF04E96D35ADCF8B" modified="2011-09-21" version="1">MTLNDKIKYLSTPLPEDIQSCMQSGFFDQAISLIDSRLASGCPEALQGRLELEKIRLIHLPEDFPYSYPQALALIRDTIPAFTEEEFRTLETAGRIDFIFVNGEKRYFRRFFETLTATHPDIAARSNPALAAESARTAEFRRETIRQIKQKGILQYHIHIQAGLEVKDGYFRPGREMVVHLPVPKEEYPSSNVRILRTSHIPSSLEPVHAPARTVSFREKLMENEGFWVEYEYDSTIRYQQPDPALVSSEQPDFEIQELLPHIQFTPFLRSLAADIIGEETNPLEKARRIYDYITTAIKYSYMKEYFMLQCIPEYCAVNRKGDCGVQALLFITLCRIAGIPARWQSGLSATPDSIGPHDWAQFYIAPFGWLHADLSFGGSAFRAGDEERRRFYFCNLDPFRMVANTEFQAPLSPVKQGLRADPYDNQVGECEIDGIGLYGTQFDYYHKMIDIHPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEM4</accession>
    <name>F7KEM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254204.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04303"/>
    <dbReference type="EnsemblBacteria" id="EGN36115">
        <property type="protein sequence ID" value="EGN36115"/>
        <property type="gene ID" value="HMPREF0994_04303"/>
    </dbReference>
    <dbReference type="GeneID" id="29725248"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="154"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="328" mass="36765" checksum="B0446B7713368564" modified="2011-09-21" version="1">MIPNTMMAWVLNSPGVLQLKEVEVPRIREDQVLIEIDRACICNGSDPGIFHGHEAYQTPLIFGHEASGRIVKKGKRVGGFELGQRVCWWFEAGAFAQYQAVTPGNTAMFQVPVNLTLDEAPVMELVLAACRALMEVRPEKGRRTVSICGLGPSGLVLVQYARALGYEHIIGWDLYETRRNLALLLGADEVYDPAWMTDGQLQDIPESDVGVLMMGDDCLPGEPTVTAFMRTIRTGGLVVSYGHPEGGCRFSPYVFQARNLWMKGPVNDMDVIRRRGEEVIGMVTDGRIKIEPLITHRVDFENFLPAFENVLEHPEEQIKVILKWRDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFF6</accession>
    <name>F7KFF6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254486.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04585"/>
    <dbReference type="EnsemblBacteria" id="EGN35032">
        <property type="protein sequence ID" value="EGN35032"/>
        <property type="gene ID" value="HMPREF0994_04585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5004"/>
    <dbReference type="eggNOG" id="COG4976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="30249" checksum="1BFE7B347C3277AB" modified="2011-09-21" version="1">MEAYTDFAYVYDVFMDNTPYDKWGGLLVSRLEKEGITDGILLDLGCGTGNMTELLSEKGYDMIGVDYSGEMLNVAMDKRARSGRQILYLQQDMREFELYGTVRAVVCVCDSLNYLLEEEEIEDTFRLVNNYLDPGGLFLFDFNTVYKYETVIGDATIAENRDNCSFIWENFYEEEGQINEYDLTVFVKEQEEEELFRKFTETHYQRGYTLEQIKRLLEKSGLVFVEALDADTLDEVTDTSERIFCVAREEGKVCDRSPDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFK5</accession>
    <name>F7KFK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family sporulation protein PdaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254535.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04634"/>
    <dbReference type="EnsemblBacteria" id="EGN35081">
        <property type="protein sequence ID" value="EGN35081"/>
        <property type="gene ID" value="HMPREF0994_04634"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5060"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="278" mass="31373" checksum="A0FA16C08D43126A" modified="2011-09-21" version="1">MLKDFIHLIQCKIKRLREAEDFKTNLRNQVIKSALFLLGVVAFVKCVTTFVPQAVSVSSTINGKELPIYCVETDEKKVALSFDAAWGNEDTQKILEILAKHNVHATFFMTGGWVDSYPEDVKAILAGGHDLGNHSENHKNMSQISNEDKEQELMKVHEKVKSLTGYEMFLFRPPYGDYDNDVIKTATKCGYYPIQWDVDSLDWKDYGVDSIVNTVCSNKHLGNGSIILCHNGAKFTADALDTLITNLKGQGYEIVPISELIYRDGYHMDAEGRQVRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFM2</accession>
    <name>F7KFM2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254552.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04651"/>
    <dbReference type="EnsemblBacteria" id="EGN35098">
        <property type="protein sequence ID" value="EGN35098"/>
        <property type="gene ID" value="HMPREF0994_04651"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5081"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="145"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="42811" checksum="6AA5D478F0DCA5D5" modified="2011-09-21" version="1">MIYAAIVGTGNISASHIQGLMTFPERCKIAALVDIYPEKAEAAKVKYQLEDAQVFDSHEALLSSGLKIDLVHVCTPPSSHAQIAIDSMKAGCNVLVEKPMAPSLKECDAMLEAEKKYGVTMGIVAQNRFRNSIYKLKKAADSGLAGKVRCAHVNSLWWRGHCYYDLWWRGTWEKEGGGPTLNHAVHHIDMINWIQGGLPEEVTSVLANVMHDNSEVEDLSFAALLYEDGSVAEVTSSVVHHGEEQGIVLQCEKAKLAAPWSCVAEVTQTNGFPVPEHNRELMKELDDFYEAIEDLPYEGHTGEIENVLSALENGTRPFITGEDGRKTVELITAIYKAGFQKRTVSLPILKEDEYYTMEGILKNAVHFYEKSASVENFTSGEITVGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFN9</accession>
    <name>F7KFN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254569.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04668"/>
    <dbReference type="EnsemblBacteria" id="EGN34879">
        <property type="protein sequence ID" value="EGN34879"/>
        <property type="gene ID" value="HMPREF0994_04668"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5099"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="330" mass="37186" checksum="0EEEAFFBCD011CE0" modified="2011-09-21" version="1">MKEQKEVLLSVQHLKKYFHVGKNAILKAVDDVSFDIYKGETLGMVGESGCGKTTCGRTCIGLYDRTDGKVLYKGQDVHALKPKEKRSFKKEVQMVFQDPYNSLDPRMTVAEIIGEGIDIHHLAKTKQERQDIIYKYLELVGLNREHANRFVHEFSGGQRQRIGIARALAVQPEFIVLDEPISALDVSIQAQIVNLLVDLQKKMGLTYLFVAHDLSMVKHISDRVAVLYLGTLVELTTSAKLYDNPLHPYTQALLSAIPIPDPEIEKERDENKIRLEGEVPSPINTKPGCRFRGRCKYAMPVCEQEMPPLTEIGEGHYVACHRCVQGNDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFY3</accession>
    <name>F7KFY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Melibiase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254663.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04762"/>
    <dbReference type="EnsemblBacteria" id="EGN34389">
        <property type="protein sequence ID" value="EGN34389"/>
        <property type="gene ID" value="HMPREF0994_04762"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5200"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015704_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Melibiase_C" evidence="3">
        <location>
            <begin position="583"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="662" mass="74577" checksum="1E9E051F09236CE0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG35</accession>
    <name>F7KG35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FRG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254715.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04814"/>
    <dbReference type="REBASE" id="38763">
        <property type="entry name" value="Lba3157McrBP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN34441">
        <property type="protein sequence ID" value="EGN34441"/>
        <property type="gene ID" value="HMPREF0994_04814"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5257"/>
    <dbReference type="eggNOG" id="COG4127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594195_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014966">
        <property type="entry name" value="FRG-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08867">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00901">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FRG" evidence="1">
        <location>
            <begin position="196"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="460" mass="52619" checksum="57C102FAB98FAA10" modified="2011-09-21" version="1">MEKYKESLHSDARQLTIYARTSPYISRAFYHIFGKKLLEEGCVDCSYVLKALGKGSYYSRLNSQGSNLYKLYAKSCMTSENIEITQEYLEAIAGNQDRNLSPLEEEALVYWIFLPYTSTNTPKREKKKEYLIAILNCLAPEWIEKYNDINEESAPKQMDLHEKNNIIYDAERCELELIDSVSGYVKDISFMKQQDTGRILYFRGHSRLSYALLPSIKRSPGWQENENRMYQELIIRCASDFAQCQSHLDYLVEMQHYGLPTRLLDITENPLVALYFACCSSPEDVGEVIVLRTQIAAMKYAKSDTAAILAALPVFDASFRTKLYESCINGIPEEEDPEYISLAAKLAGEVKSKNPGFEPRIKKKDLLSHVFIMPLRNNRRIIKQDGSFILCGLGDGNGEGNSLRSLRYRNESGKKLIFIVGNKENLLHELDQFSVNKASLFPEIDDVAEYIKLKYNGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG61</accession>
    <name>F7KG61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254743.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04842"/>
    <dbReference type="EnsemblBacteria" id="EGN34469">
        <property type="protein sequence ID" value="EGN34469"/>
        <property type="gene ID" value="HMPREF0994_04842"/>
    </dbReference>
    <dbReference type="GeneID" id="29727371"/>
    <dbReference type="HOGENOM" id="CLU_1765679_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356869" evidence="1">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="15882" checksum="9A951FB97BAD0FE5" modified="2011-09-21" version="1">MKKIISFIMVVVMTLGMTLSVQATENTMDENNLYGQPFRIIDQNGNVMITGRLGISNPTIPVGAGAEWDVNVVTGNNTMSVGVTPAANLQLQVTNSVGIPQYTYNSTGATTYISSVYNSPASGRGRYRVWNKSSYTITITQAMFNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG86</accession>
    <name>F7KG86_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254774.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04873"/>
    <dbReference type="EnsemblBacteria" id="EGN34500">
        <property type="protein sequence ID" value="EGN34500"/>
        <property type="gene ID" value="HMPREF0994_04873"/>
    </dbReference>
    <dbReference type="GeneID" id="29727831"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5316"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473039_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="491"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="594" mass="67017" checksum="1B5ADF06D5FBB74B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGE0</accession>
    <name>F7KGE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254820.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04919"/>
    <dbReference type="EnsemblBacteria" id="EGN34209">
        <property type="protein sequence ID" value="EGN34209"/>
        <property type="gene ID" value="HMPREF0994_04919"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5373"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="62"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="265"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN34209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="400" mass="44764" checksum="12BCE189FAC48343" modified="2011-09-21" version="1">MPKYSYKAKDENGKLVTGLLQAADERDLHQKLQADNKYLVNAKREEEAKRLRRIKAKYLSDFCRQIGTLSASGVSLVRALNIVAQDETNKPNEKTVFENLLRQVRQGTALSDAMEDQGEAFPELLINMFRSAETAGNLDETAMRMADFYDKQFRLNTKISNSTLYPKILSGVIVVVVIFMLSYILPQFQDLFDQMEELPVPTKILFFMSDGVKNHWMILLILLAFLIPATIFICHMPSVKLQLDKLKIKLPVFGKLLMIIYTARFARTISSLYSSGIPIVQALQIGRKTIGNTYIDSQFDDAVAKVRSGGNLSDALDNIKGFTKKLTSAVRVGEETGSLDTMLNSIADSMEYESNMAVDRMVATLEPVLIVVMAIIVGFIMISVLMPIYGSYDAISNSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGH3</accession>
    <name>F7KGH3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="6">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254853.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04952"/>
    <dbReference type="EnsemblBacteria" id="EGN34121">
        <property type="protein sequence ID" value="EGN34121"/>
        <property type="gene ID" value="HMPREF0994_04952"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5408"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_9"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0753">Steroid metabolism</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="247" mass="25979" checksum="16E3549BBE39F9AA" modified="2011-09-21" version="1">MTLEGKTALVTGASRGIGRQIALTLASQGADVIVNYNGSRERAEETVSQIRDMGRKAEALQCSVADFQACGDMVKKALELFGHIDILVNNAGITKDNLVVGMKEEDFDAVIDTNLKGTFNTIRHLYRNFMKLRGGRIINLSSVSGVLGNAGQANYAASKAGVIGLTKSVAKELASRNVTVNAVAPGYIATDMTAAMSDEAKQGIISQIPLKREGRPEDVAELVAFLAGDGGAYITGQVISVDGGMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH12</accession>
    <name>F7KH12_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">HMPREF0994_05148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255049.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05148"/>
    <dbReference type="EnsemblBacteria" id="EGN33181">
        <property type="protein sequence ID" value="EGN33181"/>
        <property type="gene ID" value="HMPREF0994_05148"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5627"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="222"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="232"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="462" mass="51054" checksum="C7B72AAECBD04424" modified="2011-09-21" version="1">MKQTETIAAIATALSDSGIGIVRISGDDAIEIGSRVYRSKNGCHSLKDYGSHTIHYGFIMDGEEILDEVMAAVMKAPNSYTKEDTVEINCHGGVLIVQKVLETVLRNGARLAEPGEFTKRAFLNGRIDLAKAEAVMDIIHSRNEFALKSSMKQLKGSISDCIRQMREEILYEIAFIESALDDPEHISTEGYPEKLLPKIGDLLLRCNKLIDSADDGKVLKEGINTVIVGKPNAGKSSLMNLLVGEEKAIVTEVAGTTRDVLEESIRLHGIGLNIIDTAGIRSTEDVVEKIGVERALKIASDADLILYVVDSSVALDESDEEILDLIRGKKCIVLLNKTDLVPVVEEEELRKKLRDAEISVIRTSTRDNTGIEEFENTIKEMFFSGALSMNEEVIITNMRHKQALEEARDSLLMVKKSLEDEMPEDFYSIDLMSAYASLGYIIGEEVGEDLVNEIFSKFCMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH44</accession>
    <name>F7KH44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255079.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05180"/>
    <dbReference type="EnsemblBacteria" id="EGN33213">
        <property type="protein sequence ID" value="EGN33213"/>
        <property type="gene ID" value="HMPREF0994_05180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5661"/>
    <dbReference type="eggNOG" id="ENOG5032RUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188176_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="79" mass="9170" checksum="B0E37225755279C1" modified="2011-09-21" version="1">MTAKHPMIPFPVIVRAADGDIEAVNQIVRHYSGFIASRSMRPMKDEYGNTHMVVDETLRRRMETRLIAKILSFEIREPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH55</accession>
    <name>F7KH55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006776315.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33224">
        <property type="protein sequence ID" value="EGN33224"/>
        <property type="gene ID" value="HMPREF0994_05191"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5671"/>
    <dbReference type="eggNOG" id="ENOG5030FKI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189661_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="63" mass="7128" checksum="EC32E0DFC67780E7" modified="2011-09-21" version="1">MTKEIEIQGCITIPKDVSMDEVIDKFIAFIEKNEWSFGGGYRTIIDGYYMNADGTKGKCVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHL9</accession>
    <name>F7KHL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05348"/>
    <dbReference type="EnsemblBacteria" id="EGN32789">
        <property type="protein sequence ID" value="EGN32789"/>
        <property type="gene ID" value="HMPREF0994_05348"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688472_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031965">
        <property type="entry name" value="CBM26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16738">
        <property type="entry name" value="CBM26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364050" evidence="3">
        <location>
            <begin position="29"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="CBM26" evidence="4">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CBM26" evidence="4">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CBM26" evidence="4">
        <location>
            <begin position="243"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="400" mass="43709" checksum="0ED4FF3017B51FDD" modified="2011-09-21" version="1">MLKRWKKWGLLVLGVLLGVFWVPFSVLAENGEERVAVYVQVPEDWENPCIWAWDEEGNNAFAAWPGEEMDADRGNEGWYYVWIPSWADHVIVNADEGDVQTGELVLEGRNTWIVVEDGENVELFTDPQTKGDIPEYVEKFVVRVKVDESWKDPCLWAWSAPDGKNVFEAWPGEALVLKESGWYEVKVPVWVNSIIVNADDGAVQTEDISIDPADIWVSVGEDGSFDFSYEDPDAEEVPDVTVWVKAPADWESPCLWAWSAPDGTNAFAAWPGEALAEDGSGWLKISVPGWVNSVIVNGSEGSVQTADLSVDTGKDVWVVVSSAEDASVFYEEPEGAVVAEGTAGETEERMTAEETQEPGAEETGVSVEQSGSRAPVIILVAVVTAAVIAAAVVAGKKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI34</accession>
    <name>F7KI34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255233.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05390"/>
    <dbReference type="EnsemblBacteria" id="EGN32831">
        <property type="protein sequence ID" value="EGN32831"/>
        <property type="gene ID" value="HMPREF0994_05390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5893"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="258" mass="27749" checksum="78A3B1BF4F61FAC5" modified="2011-09-21" version="1">MEYIVYEQKGAYAVITISREKALNALNSQVLDELDKTLDGVNLDEVRCLILTGAGTKSFVAGADIGEMSTLTKVEGEAFGKKGNDVFRKLETFPIPVIAAVNGFALGGGCEISMSCDIRICSDNAVFGQPEVGLGITPGFGGTQRLARLVGPGMAKQMIYTARNIKADEALRIGLVNAVYTQEELMGAAEKMAAGIAKNAPIAVRNCKKAINDGLDADMDEAIVIEEKLFGDCFESYDQKEGMAAFLEKRKVEKFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI87</accession>
    <name>F7KI87_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05566"/>
    <dbReference type="ESTHER" id="9firm-f7ki87">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN32391">
        <property type="protein sequence ID" value="EGN32391"/>
        <property type="gene ID" value="HMPREF0994_05566"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6082"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="529" mass="59536" checksum="F36201D83BDDC8A3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIF6</accession>
    <name>F7KIF6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fn3_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255442.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05635"/>
    <dbReference type="EnsemblBacteria" id="EGN32346">
        <property type="protein sequence ID" value="EGN32346"/>
        <property type="gene ID" value="HMPREF0994_05635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6159"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005235_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="342"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="842" mass="92273" checksum="5BE02D47BE4AE883" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIG2</accession>
    <name>F7KIG2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32352.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360186.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05641"/>
    <dbReference type="EnsemblBacteria" id="EGN32352">
        <property type="protein sequence ID" value="EGN32352"/>
        <property type="gene ID" value="HMPREF0994_05641"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050362_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="278"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32352.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="487" mass="56899" checksum="4DADDD80B376E5EB" modified="2013-09-18" version="2">MDNIILYLLTIIQEQYNTICCLLNLICRYFPLRQWAFDDSHSPKYQKFTTDRLPLIKPFIKQDWQFLLEYYLWKYGKPVTPVQRRNGKSIPEDVFCPLCGAPHHYLYDNNGGNGQYQCKICGQTFVTGDVVPSPLRFACPYCGHSLVPKKDRKFFRIHKCVNPRCSFYLHNLSKVDKNLLEEDYDKNKYKLHYLYREFTVDFFRMDLDSLPKNSSSLKFSKHNAHIMSLCLTMHVNLQLSLRKTAQALYDLYGIRISHQQVANYARTAAIVIKPFVDHYEYPKSSIFTADETYIKVRGIKGYLWFIMDAASRSILGYQVSDNRSVGPCILAMRMAFRGMKRLPEKFRFIADGYSAYPLAAQQFARELGDSFKFDITQVIGLTNDDAVSKEFRPYKQMIERLNRTFKSTYRVSCGYDNYNGANYNVALWVAYYNFLRPHKHNHYRVLNPVDMLEGADNMPGKWQLLILLGQQTILHLQEQQEAGSICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KII2</accession>
    <name>F7KII2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255468.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05661"/>
    <dbReference type="EnsemblBacteria" id="EGN32285">
        <property type="protein sequence ID" value="EGN32285"/>
        <property type="gene ID" value="HMPREF0994_05661"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527518_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="385"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="524" mass="58816" checksum="4C736D4BEE0C734B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ04</accession>
    <name>F7KJ04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255609.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05833"/>
    <dbReference type="EnsemblBacteria" id="EGN31461">
        <property type="protein sequence ID" value="EGN31461"/>
        <property type="gene ID" value="HMPREF0994_05833"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6383"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="34067" checksum="25678CA542204E5C" modified="2011-09-21" version="1">MAHKKKNPVTEGKKSFNWPDKIFGAAVLILSILVFLIIAYPLWFIIIASISNSNMVNLGKVTFLPKDIRFYGYQQIMDDARIWMGYANTILYVVAGTILNMAVTMPAAYALSRRNFKARNKVMFYFVFTMFFSGGLVPLYMTVSSLGLISTKTILIIFVAVNTYNLIIARTFIENSIPEDLYEAAVLDGCSHFNYFVKVVLPLSKAVISVLILYYAVFHWNDFFNALLFNSNAKNAPLQIILREILLLNQAFSSGVGGVQGGYAQGAADQVKYAVIIVSTLPILCVYPFIQKYFEKGVMIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ79</accession>
    <name>F7KJ79_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_05911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255687.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05911"/>
    <dbReference type="EnsemblBacteria" id="EGN31539">
        <property type="protein sequence ID" value="EGN31539"/>
        <property type="gene ID" value="HMPREF0994_05911"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6469"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="426"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="690"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN31539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="811" mass="91694" checksum="620E035B2B8FEE99" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJB6</accession>
    <name>F7KJB6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05958"/>
    <dbReference type="EnsemblBacteria" id="EGN31586">
        <property type="protein sequence ID" value="EGN31586"/>
        <property type="gene ID" value="HMPREF0994_05958"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6521"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423749_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="432"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN31586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="648" mass="72011" checksum="4AE465DA52EACB20" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJE7</accession>
    <name>F7KJE7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NERD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05976"/>
    <dbReference type="EnsemblBacteria" id="EGN31330">
        <property type="protein sequence ID" value="EGN31330"/>
        <property type="gene ID" value="HMPREF0994_05976"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6542"/>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198118_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="26924" checksum="F2FA7169ADC6B229" modified="2011-09-21" version="1">MLSVLCLILVSVYLYRHHLYNKLDRQKLSHSSYYDVSFGGERKCSDEVVRILKDVGGYKKIVVNWHYCENGEPSCADVILLHETGIYVVEAKDYQGWISGEPEDEYWVQTLCGSQLTSYKNYFYNPLMKNSSCIRSLQKELPDMKWLPFFSMAVFGNQCELENAGLSDNTSKIILVRQLSYTIYGMVRSARKFLASQVIDEIYDRLQVLPSAKTAEGKYSGLDKKPEFYYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJT4</accession>
    <name>F7KJT4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255889.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06113"/>
    <dbReference type="EnsemblBacteria" id="EGN30739">
        <property type="protein sequence ID" value="EGN30739"/>
        <property type="gene ID" value="HMPREF0994_06113"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN30739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="183" mass="22062" checksum="982F6FD9BDE78AB6" modified="2011-09-21" version="1">MILFVFDTEEERDKFIYIYDKYKKTAIYTIKLFISDNYIVEDLLQDIFIIIAKNLQKIDETDEKRTRNYIITITRNYCKSHLRKAARSKEDFIEEVEESYSFSTSQNREDILDGILHKESYQRLVDEIKQLDDKYRIALELKYITGLDDVQIAKIVGTTKKNIQMRIYRAKLMLRKRLEDLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJY7</accession>
    <name>F7KJY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN30669">
        <property type="protein sequence ID" value="EGN30669"/>
        <property type="gene ID" value="HMPREF0994_06176"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033I6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210311_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="57" mass="6548" checksum="7C51C279E64CB414" modified="2011-09-21" version="1">MATKSILKDIHIKDKRLAHTFVEALSQAEHSKYKPAELSRECTEITGDKIKEFFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKA4</accession>
    <name>F7KKA4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30202.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360036.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06283"/>
    <dbReference type="EnsemblBacteria" id="EGN30202">
        <property type="protein sequence ID" value="EGN30202"/>
        <property type="gene ID" value="HMPREF0994_06283"/>
    </dbReference>
    <dbReference type="GeneID" id="29724082"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024620_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30202.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="334" mass="37733" checksum="802CFFE1E8882EED" modified="2013-09-18" version="2">MGNFTEYRIPAIVVTKKGTIITACESRREAGNDWSGVWITIRRSVDGGKTFSRPVYPHESLGEKVGETVVTWSNPVLIADEERIHLIFHQDYEKAWYCCSCDEGISFGVPVEITETFRALPWNWNVCASGPGHGIVSDRGRLVIPIWLAKGEIRLDLDKSGRIKNHFPSVAGCIYSDDRGTSWKPGFVTQGIENANETTVVQMCSGNFLFNFRNERFEKCRVMGIADAQLSKLSRVWSETSLPDPTCFGSMVKTDKKKYFVNCAHNDPAGFYGERIHLTVYESQDEAVTWKPLFEVDEKGGYADIGADEKGLYILYERGVAGRVKMLLLKRYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB4</accession>
    <name>F7KKB4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06293"/>
    <dbReference type="EnsemblBacteria" id="EGN30212">
        <property type="protein sequence ID" value="EGN30212"/>
        <property type="gene ID" value="HMPREF0994_06293"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6897"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="35494" checksum="D5836E8C0725D83A" modified="2011-09-21" version="1">MRRYNDSKGKGMKMKRNKWPYLFSLPFLGAYGLFMLFPMVYSFYLSLFDYNGIVEKHFVGLANYINLFTRDKLFLKSLFNTVLIMLMSLPVNLILGLITAYLLFQLAKGRRFFQVVNFLPYITTPVAIGFIFSYIFDWNSGILNGLLTHFGILSENYFWLQHPWSARLIVAVMIVWRNFGYCMMIYLSGMTAIPQDVYEAAAIDGAGKVKTFLHIIIPLLKNVSVFLFITALIGGFQMFDEPVQLYSGWSAASKSVGGPDYSVLTVIWKFYDDSFGSSTRLGYGAAIAYTLFVIIGGCSLFSFFFSNRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB6</accession>
    <name>F7KKB6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256065.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06295"/>
    <dbReference type="EnsemblBacteria" id="EGN30214">
        <property type="protein sequence ID" value="EGN30214"/>
        <property type="gene ID" value="HMPREF0994_06295"/>
    </dbReference>
    <dbReference type="GeneID" id="29726976"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6899"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="31890" checksum="A945CECAF6D0B7A4" modified="2011-09-21" version="1">MNENITYIFQGTNYIDLTLYQYGREKCAPLLSCGPAVHNHYLLHYILEGKGLFTIGTDRHYALHAGQAFLICPKSITTYTADKADPWTYIWIEFDGLKIPPFLSDAGLGLKHPIYTPSDPAGARELESLMTAMLEQHSSSLRLLGNMYWILETLIRTSSQRKPPKTGNLQEFYVHEAMMYIERHYNQNISVAQLADWCNLDRSYFGKIFKDTVLVTPQEYIIRYRINTACDLLKNTDLSIGDISAQVGYDNQLHFSRAFKKVMGMAPRDWKKRNRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKL7</accession>
    <name>F7KKL7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsL</name>
        <name evidence="7" type="ORF">HMPREF0994_06396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 5">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256158.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06396"/>
    <dbReference type="EnsemblBacteria" id="EGN48004">
        <property type="protein sequence ID" value="EGN48004"/>
        <property type="gene ID" value="HMPREF0994_06396"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7002"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN48004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="139" mass="15123" checksum="72C984BB360B3B58" modified="2011-09-21" version="1">MPTFNQLVRKGRQTSVKKSTAPALQKGYNSLHKKATDASAPQKRGVCTAVKTATPKKPNSALRKIARVRLSNGIEVTSYIPGEGHNLQEHSVVLIRGGRVKDLPGTRYHIIRGTLDTAGVANRRQARSKYGAKRPKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKY9</accession>
    <name>F7KKY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256280.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06518"/>
    <dbReference type="EnsemblBacteria" id="EGN47529">
        <property type="protein sequence ID" value="EGN47529"/>
        <property type="gene ID" value="HMPREF0994_06518"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7139"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034082_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="429"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="553" mass="62790" checksum="C60A76C8CEC2DF88" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLC2</accession>
    <name>F7KLC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256404.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06651"/>
    <dbReference type="EnsemblBacteria" id="EGN46575">
        <property type="protein sequence ID" value="EGN46575"/>
        <property type="gene ID" value="HMPREF0994_06651"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7273"/>
    <dbReference type="eggNOG" id="ENOG50303V6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1862596_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="137" mass="15223" checksum="A7F042D890CCE4DE" modified="2011-09-21" version="1">MKKKAVICSIITVLCIVAAVFLRFAMEDTNPEYTEVKATVVSSDNIVRKVLGKRQTQYEVIVEYEGQEYKLKNTHSSAPYIPGKEVTALLHDDKLYANIEGITSTTPVAMVYFVFLFGSFAMVCVSVTLISKARTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLF6</accession>
    <name>F7KLF6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="5" type="ORF">HMPREF0994_06687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256440.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06687"/>
    <dbReference type="EnsemblBacteria" id="EGN46611">
        <property type="protein sequence ID" value="EGN46611"/>
        <property type="gene ID" value="HMPREF0994_06687"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7312"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="521"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="255"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="342"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="679"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="833"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="960"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN46611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1186" mass="135962" checksum="92BD61A4B790FAD9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLL4</accession>
    <name>F7KLL4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="5" type="ORF">HMPREF0994_06690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06690"/>
    <dbReference type="EnsemblBacteria" id="EGN46614">
        <property type="protein sequence ID" value="EGN46614"/>
        <property type="gene ID" value="HMPREF0994_06690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7316"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN46614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="347" mass="36557" checksum="5CEEFDE4A871B6B1" modified="2011-09-21" version="1">MAGYTERDMKMADYVKVAVDAMGGDNAPGEIVKGAVDAVCAEKKIKVFLVGKEEQVKAELSKYTYPQEQVEVVNATEVIAMAEPPVAAIRGKKDSSIVKGLYMVREGKCDAFVSAGSTGAVLAGGQVIVGRSKGVERPPLAPLIPTEKGASLLIDCGANVDAKPSQLVQFAKMGSIYMENVMGIKNPKVGIVNIGAEEEKGNALVKETFPMLKACSDINFIGSIEARDIPAGAADVVVCEAFVGNVVLKLYEGVGSTLIKKVKGGMMVNLRSKIGALLVKPALKQTLKAFDLEQYGGAPLLGLKGLVVKTHGSSKAVEIKNTILQCVTFKEQDINGKIQKVISGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLR4</accession>
    <name>F7KLR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256546.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06793"/>
    <dbReference type="EnsemblBacteria" id="EGN46385">
        <property type="protein sequence ID" value="EGN46385"/>
        <property type="gene ID" value="HMPREF0994_06793"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034082_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="439"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="568" mass="63559" checksum="26C8D799280BA571" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLS9</accession>
    <name>F7KLS9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN46318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256558.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06808"/>
    <dbReference type="EnsemblBacteria" id="EGN46318">
        <property type="protein sequence ID" value="EGN46318"/>
        <property type="gene ID" value="HMPREF0994_06808"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7437"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033147_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="302" mass="33213" checksum="54DBF633F7E6680D" modified="2011-09-21" version="1">MGKKFSGASQLLSRFRSWIQAGAALLTNLHLPNFLKGGLYQGAGKTVCVPGLNCYSCPAASGACPIGAFQAVVGSSKFSFSYYITGFLILLGVLLGRFICGFLCPFGWFQELLHKIPTKKLSTKKLKPLRYFKYAVLLVMVFLLPAFLVNDVAMGDPFFCKYLCPQGVLEGAIPLSLANSGIRAALGKLFTWKFSILLSVIVLSVLFYRPFCKWLCPLGAFYALFNRVSLFQMKVDKSKCVSCGKCARACKMDVDVTKTPNHTECIRCGMCVRACPTNAVCFRYGFGNGKETPKKTTMEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSE4</accession>
    <name>S2KSE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05399">
        <property type="protein sequence ID" value="EPC05399"/>
        <property type="gene ID" value="HMPREF0994_07067"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3054955_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="53" mass="6116" checksum="2730EFDB7AB68330" modified="2013-09-18" version="1" fragment="single">FRPAMGKQEEQEGSSYTVLWMRYGNGMKADREHGVDDQETGRITIKVTKLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVM1</accession>
    <name>S2KVM1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_07321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EPC05035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360347.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07321"/>
    <dbReference type="EnsemblBacteria" id="EPC05035">
        <property type="protein sequence ID" value="EPC05035"/>
        <property type="gene ID" value="HMPREF0994_07321"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EPC05035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="364" mass="41511" checksum="6B7690D1C640B9E0" modified="2013-09-18" version="1">MSKVILTGDRPTGRLHVGHYVGSLKRRVELQNSGEYDKIFIMIADAQALTDNADNPEKVRQNIIEVALDYLACGLDPEKSTLFIQSQIPELCELSFYYMNLVTVSRLQRNPTVKSEIQMRNFETSIPVGFFTYPISQAADITAFNATTVPVGEDQAPMIEQTKEIVHKFNSIYGETLTDPNILLPDNKVCMRLPGIDGKAKMSKSLNNCIYLSDTEEEVRQKIMSMFTDPGHLRVQDPGKVEGNPVFIYLEAFSNEDQFARYLPEYQNIQEMEDHYARGGLGDVKVKKFLNNVMQEELEPIRKRRKEFEKDIPEIYNILKKGSDVAEAEAANTLSNVKRAMKINYFEDNALIQEQAERFAAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVX3</accession>
    <name>S2KVX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360159.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07210"/>
    <dbReference type="EnsemblBacteria" id="EPC05155">
        <property type="protein sequence ID" value="EPC05155"/>
        <property type="gene ID" value="HMPREF0994_07210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045118_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="360" mass="40678" checksum="7B9C8DC0FA438654" modified="2013-09-18" version="1">MGKEVITKELEKRHIPELLRLSDNTPVDTPQLWETRRKEIRDILQKECYGYIPETGWETEWETVSEEENAFGGKARMRTVDVRIRSGRGYVSYPFQLTVPKNIEKPPVFLYLSFFPLSSSEIVEEITDNGFAVARVSYQDIAPDQNDGFQNGPGSLFPGNAYDSWGKLGVWAWGLSRIMDYLVQEETIDAGRVAVVGHSRLGKAALLCGAMDERFSLVIACESGAGGAALFRGKEGENVADLCRNFPYWFCGNFKKWQNREEELPFDQHFTAALAAPRHLYLAGAVDDEWADPLSEFLTGQAVTPVYEMLGQQGLAADRLPSTGDVFHEGRVGFHLRPGTHYMGRDDWKLFMEYRKKQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2L9Z9</accession>
    <name>S2L9Z9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Delta-lactam-biosynthetic de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360203.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07240"/>
    <dbReference type="EnsemblBacteria" id="EPC05091">
        <property type="protein sequence ID" value="EPC05091"/>
        <property type="gene ID" value="HMPREF0994_07240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_12_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10948">
        <property type="entry name" value="CE4_BsPdaA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014235">
        <property type="entry name" value="Spore_PdaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF78">
        <property type="entry name" value="PTHR10587:SF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="80"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="272" mass="30831" checksum="FF8BEBCA7BA3FC99" modified="2013-09-18" version="1">MKNREIIKGITGILFLFILAFLAGRFLAQAVDAVSSSSVLPAEGNWGLSFREDGKPPVANASFEELAKYNAFYAENTQEKVLYLTFDCGFENGNTPAILDALKKHNVKATFFIVGNYLETSPDLVKRMLDEGHIVGNHSYHHPDMSQMDKEAFTKELGELETLYEQTFGQPMQKFYRPPQGKYSANNLQIASDLGYKTFFWSLAYVDWEQDNQPTHEEAFNKLLKRVHPGAIVLLHNTSKTNGEILDELLTKWEEMGYSFRSLTQLPGVENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2X2</accession>
    <name>F7K2X2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00201"/>
    <dbReference type="EnsemblBacteria" id="EGN39234">
        <property type="protein sequence ID" value="EGN39234"/>
        <property type="gene ID" value="HMPREF0994_00201"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363469" evidence="1">
        <location>
            <begin position="34"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="431" mass="47998" checksum="CCAD09210DDF576F" modified="2011-09-21" version="1">MKRKRILAIALTVALVAGSLSGCGSSTKETVSGAEKPGESKEQITLTFLRAGTSENVQKVYEELISAYEAEHPNIKIEYEQVGFGNELETKLNTLYASGMAPDIVRAPISTIAERASRGQYANLDAYIDSWEEKDDIMPTAFEVASYNGNKYGIAIGIEASFLLYRKDMFREAGLDPQNPPKNWDELLEYAEKLTVRDGDAVTRAGFSIPTSAGHSTFIPFARQNGAQLVDVEKDVPTFNDAKSAEALDYLSQFSQENLLIPFINNKDDNPFDSGKAAMTYGNINSFITLQAKEVDWLDELGFAPGIEKEKISSFGGCQIMFMSEEGKHKEETWEFMKYLFENENVWKLTTEAGAAPVKLSLKDKYLEEYPEIGAAYLEALEYAEGMPKVTWAALFEEAVCTAYEEAMYGKKDGQQALDDAYNWLMKEMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2X3</accession>
    <name>F7K2X3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="10">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metG</name>
        <name evidence="14" type="ORF">HMPREF0994_00202</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250151.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00202"/>
    <dbReference type="EnsemblBacteria" id="EGN39235">
        <property type="protein sequence ID" value="EGN39235"/>
        <property type="gene ID" value="HMPREF0994_00202"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.213"/>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="4"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="421"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="339"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN39235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="555" mass="63619" checksum="F7E2937D9214FEE1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K353</accession>
    <name>F7K353_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00282"/>
    <dbReference type="EnsemblBacteria" id="EGN33423">
        <property type="protein sequence ID" value="EGN33423"/>
        <property type="gene ID" value="HMPREF0994_00282"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_695959_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="396" mass="46506" checksum="367E4FA5FD556E16" modified="2011-09-21" version="1">MSNTVDDKSVIRNIILESQHLRNKSSESIENIVSDICGLQYDPNPTIHLNQYMMLWNRKKDFTVEQLDIAAYKEFKVIETFAFKRNMFFVPYDEYALYRTATKGIVRWGDSDESWLRVTNNPQIQSAEVKLKESLTGLQGMTAKQIWEHLNLSYEWHKYRREHDSNFELPIFRAFYRMVRKGELVTCGRNPGTFREPVYILKENLGITDWPDKPIDEKQAIICMVEKLIASLGVTDPVHISHISGIATIDILPVFQELVLEKKILQLPYKIGRKNYYIHSSKTHFLDSKQTEDSNEVRLISPMDTIVRDKNWLETFFDYSFSFEYFKKKGMKWPLSILVGNQFIGYIDCKMEWKTKKLIIKEKNIFNSDFNNYKGIDSAIQELASFHEAKEIIEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3H2</accession>
    <name>F7K3H2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AIRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250278.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00329"/>
    <dbReference type="EnsemblBacteria" id="EGN33470">
        <property type="protein sequence ID" value="EGN33470"/>
        <property type="gene ID" value="HMPREF0994_00329"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.353"/>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="115"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="28462" checksum="1AB20DF12D225F2D" modified="2011-09-21" version="1">MDTQEILLQFKNGQMSLEEAEGYLKRQPFEEMGYAKLDSHRKLRSGFAEVIFCSRKADAHLLEIFRRLYEEEGEVLGTRASQHQYELLKKEFPQVQYDEISHIIKIEKEGKKRIGKIAVCTAGTADIPVAEEAAQTAEFFGSNVDRIYDVGVSGIHRLMSRLDVIQSANCVVAVAGMEGALASVIGGLVSNPVLAVPTSVGYGANMNGLSALLTMINSCANGIAVLNIDNGYGAGYMATQINRLAERDGNHSFGEETEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3K0</accession>
    <name>F7K3K0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250378.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00429"/>
    <dbReference type="EnsemblBacteria" id="EGN31944">
        <property type="protein sequence ID" value="EGN31944"/>
        <property type="gene ID" value="HMPREF0994_00429"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.469"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014111_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="837"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="907" mass="100464" checksum="04E88605EBAD08F8" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3K3</accession>
    <name>F7K3K3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250381.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00432"/>
    <dbReference type="EnsemblBacteria" id="EGN31947">
        <property type="protein sequence ID" value="EGN31947"/>
        <property type="gene ID" value="HMPREF0994_00432"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_34_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="201" mass="23841" checksum="3D16ABF49D7613EE" modified="2011-09-21" version="1">METKELIQEAALDLFSRKGFDSSSVRDIAAQIGIKDSSLYFHFKSKQAILDSLMDRFIHISRQMMEGLDEGISSITAMDDEHFYAVTEQYIQSYFMDTFISRILMIMNHERSHNDQLREQYINWCIEKPLDFQTTVMKKLQDIGYLKKENPRHLALEYYSPVYLFFNQYMNHDYTEKDTEHFKQAVMSAAGSFLQTYRKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Y0</accession>
    <name>F7K3Y0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250508.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00559"/>
    <dbReference type="EnsemblBacteria" id="EGN44747">
        <property type="protein sequence ID" value="EGN44747"/>
        <property type="gene ID" value="HMPREF0994_00559"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145226_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013367">
        <property type="entry name" value="Flagellar_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12611">
        <property type="entry name" value="Flagellar_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02530">
        <property type="entry name" value="flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="134" mass="15150" checksum="A414F5160C4BB5B6" modified="2011-09-21" version="1">MDPLRYNQLLQRPVYTGNPVDIQQNRDSRETSGEENTSFQKVLEEKLREESGISFSKHAMERVAERNVDVSAEQLERLNEGVRLAEEKGLRTPLILMDTTAFLVNVPNNKVVTVVNDESLKGSVFTNIDGTVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Z1</accession>
    <name>F7K3Z1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250519.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN44758">
        <property type="protein sequence ID" value="EGN44758"/>
        <property type="gene ID" value="HMPREF0994_00570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.621"/>
    <dbReference type="HOGENOM" id="CLU_1319565_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="208" mass="23425" checksum="F00A28F8DFACBA26" modified="2011-09-21" version="1">MDLSIKNCRKCHILDPQTGAVLSEAAVSYTRENEIYLTFPGWELVMEEAYLMPVVFFDSINGLVTCNCSICQIEPVIDKKGYYHGFCHILSVKNTADRHEDFRLPLTITVNMSYIDPETGRSGGIGGVTSNISAGGVYIIAAQKLPVQVFYTHFQHNVLPIAPQTRVLRTEPLSNGKYGYGCCFEDLSSYTESLLRRFIFHMESIHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4F1</accession>
    <name>F7K4F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease, DNA polymerase III, epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250680.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00731"/>
    <dbReference type="EnsemblBacteria" id="EGN44080">
        <property type="protein sequence ID" value="EGN44080"/>
        <property type="gene ID" value="HMPREF0994_00731"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.794"/>
    <dbReference type="eggNOG" id="COG2176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_7_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="26676" checksum="BFFD82EB4AAC9135" modified="2011-09-21" version="1">MLKSYIAFDLETTGLDPEQNEIIEIGALKVRDGKVEERFMEFIRPCQPVSKTITDLTGITNEMVADAEDSKTVIPAFLEFCGNDVLVGHNIIFDYSFMKNQAAILGYGFEKQGVDTLRIARRVHKDMRSKSLEALCSYYSIVNPAAHRAYHDALATAKLYQTLAHYYEEKEPQVFQPVVLNYKEKGREEMPATKKQVDFLMRLAVQKKAAVTWDPDKLTKSEASGLIESLLAGQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4H1</accession>
    <name>F7K4H1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00727"/>
    <dbReference type="EnsemblBacteria" id="EGN44076">
        <property type="protein sequence ID" value="EGN44076"/>
        <property type="gene ID" value="HMPREF0994_00727"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.789"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN44076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="30426" checksum="514C5964C294A2BE" modified="2011-09-21" version="1">MSTMIETLKLYLQYPFVRYALIVGVLIALCSSLLGVTLVLKRFSFIGDGLSHVAFGAMAVAAVLNLSDSMLFVLPATVLCAILLLRTGQNTKIKGDAAIAMISVGALAIGYLLMNLFSTSSNLSGDVCSTLFGSTSILTLTKTEVWLCAVLSVIVVITFILFYNKIFAVTFDEGFAQATGVKAGMYNLLIAVIIAVIIVLAMNLVGPLLISALVIFPALSAMRLFKSFRSVTICSAILSVICALTGILISILAGTPVGSTIVAVDIAAFALFSLLGSLKGGVRFSMIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4U3</accession>
    <name>F7K4U3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250821.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00872"/>
    <dbReference type="EnsemblBacteria" id="EGN43181">
        <property type="protein sequence ID" value="EGN43181"/>
        <property type="gene ID" value="HMPREF0994_00872"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.950"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="27899" checksum="68FF11BDC060984F" modified="2011-09-21" version="1">MKVCAVTGGAMGIGKEIVKTFAGAGYRVVFIDKDETAARKTEEELQAENRNVSAMVGDIGDEAAVKAFADYVIKECGSVNALINNACISRRGLLSGCGAEDFNYVLRVGVTAPYLLTLYLKEHFAKQAAIVNISSTRAFMSQQDTESYTAAKGGITALTHALAVSLSGKVRVNSIAPGWIDTWESHGLPEPVYSAPDREQHPSGRVGNPADIARAALFLCDERNSFINGENINIDGGMSHLMVYHDDCGWRYEGDSSGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K555</accession>
    <name>F7K555_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250942.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00993"/>
    <dbReference type="EnsemblBacteria" id="EGN43302">
        <property type="protein sequence ID" value="EGN43302"/>
        <property type="gene ID" value="HMPREF0994_00993"/>
    </dbReference>
    <dbReference type="GeneID" id="29724875"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1084"/>
    <dbReference type="eggNOG" id="ENOG502Z7M5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314935_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="916" mass="100719" checksum="89332687338D13B4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K557</accession>
    <name>F7K557_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250944.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00995"/>
    <dbReference type="EnsemblBacteria" id="EGN43304">
        <property type="protein sequence ID" value="EGN43304"/>
        <property type="gene ID" value="HMPREF0994_00995"/>
    </dbReference>
    <dbReference type="GeneID" id="29725556"/>
    <dbReference type="HOGENOM" id="CLU_303615_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="980" mass="111837" checksum="A5063673875C79E7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K589</accession>
    <name>F7K589_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250909.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00960"/>
    <dbReference type="EnsemblBacteria" id="EGN43269">
        <property type="protein sequence ID" value="EGN43269"/>
        <property type="gene ID" value="HMPREF0994_00960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1049"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="279" mass="30681" checksum="09EF7828135B4A00" modified="2011-09-21" version="1">MSYKIVVDSCCELPEELKGDPRFEIVPLGIEVGDWHIQDDAGFNQAEFLKKVAECPTCPRSSCPSPDRYKQSFDCDADHIYVVTLSANLSGSHNSAVLGKNLYEEKHKDKKIHVVDSKSASCGEAQIALKAMELEEQGLSFEEIVKRLEDFRDEMNTYFVLNNLETLRKNGRLTGVKALVASTLNIKPVMGATPEGTIAQLGQAIGFKKALQKLADTVVQGTKNPQKKCLMITHCNNPAKAESVRQMILEKVQFADSRILDTAGISSMYANDGGIIIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5E5</accession>
    <name>F7K5E5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251023.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01074"/>
    <dbReference type="EnsemblBacteria" id="EGN43047">
        <property type="protein sequence ID" value="EGN43047"/>
        <property type="gene ID" value="HMPREF0994_01074"/>
    </dbReference>
    <dbReference type="GeneID" id="29725802"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089241_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="89"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="264" mass="30450" checksum="9F5748EB094B5435" modified="2011-09-21" version="1">MNENTNQSCPCCPNHCPSDALQCGKGRAYFSEASETNQPGSDERDTQNASHHHSAHARHEELRERHEEFRERRGRRNGREPFPEHFFPDGQPLTGEEQLFEQFRACAHALHHPGNGKSGQLRILSILSARSPITQRQLMDILDVRSGSLSEILGKMEAEGYITRSPNEQDKRGVDVTLTPAGLEAAEQMHVSRETSVQDFFSCLDEEEKEQLSRILDKLLADWRSKKEMYGGRDRDNRGRDSRERGRREDGRRERRSVERHHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K600</accession>
    <name>F7K600_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">HMPREF0994_01279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251228.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01279"/>
    <dbReference type="EnsemblBacteria" id="EGN42311">
        <property type="protein sequence ID" value="EGN42311"/>
        <property type="gene ID" value="HMPREF0994_01279"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1397"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="285"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="457"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN42311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="608" mass="66950" checksum="3899CA26D0420371" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6C3</accession>
    <name>F7K6C3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YrbI family 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251298.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01349"/>
    <dbReference type="EnsemblBacteria" id="EGN42211">
        <property type="protein sequence ID" value="EGN42211"/>
        <property type="gene ID" value="HMPREF0994_01349"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106694_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN42211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="172" mass="19464" checksum="EB77B6D499B4B50F" modified="2011-09-21" version="1">MDYNKINFLIIDVDGTMTDAGIYYDEHGNEYKKFCTKDAAGFFAAREANMKIMVLTGRQCEAVSRRMAELKVDYIVQNIKDKEVYLKNFIEKEKLRQDEIGYLGDDLNDLSGMRFAGFVGCPADACEEVKSVADYVSTVKGGYGAVRDIISHILRIRGQWNDIIEKIYGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6D3</accession>
    <name>F7K6D3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01438"/>
    <dbReference type="EnsemblBacteria" id="EGN41912">
        <property type="protein sequence ID" value="EGN41912"/>
        <property type="gene ID" value="HMPREF0994_01438"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1566"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="338" mass="38310" checksum="F1C4E50469CFCC6B" modified="2011-09-21" version="1">MEDCMRKLVSIVIPCYRSAEMIGGVVADINREMEKLQGKYRWEIILVNDCSPDNTFDVIRELCREYTNICGINLARNFGQHAALMAGFHQVKGDILVCMDDDGQTPAFAIKDLLQGLEEGSDVVYAKYEHKHHNAFRNFGSRVNDLMLKFMLGKPADLYVSSFFAARRFIVDEMLRYQNAYPYVIGLVLRATRNIKNVTVEHQDRKAGESGYTLSKLLGLWFNGFTAFSEKPLRVATMIGTGCAFLGFLYGLYTIIKKLVNPMVPIGFSSLMSALMFIGGMLMLMVGLVGEYIGRMYICMNNAPQYVVREIVGEEEGEKDTDQKEETVQKKQEKPQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6E5</accession>
    <name>F7K6E5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pseudaminic acid CMP-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251399.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01450"/>
    <dbReference type="EnsemblBacteria" id="EGN41924">
        <property type="protein sequence ID" value="EGN41924"/>
        <property type="gene ID" value="HMPREF0994_01450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1580"/>
    <dbReference type="eggNOG" id="COG1083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042930_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020039">
        <property type="entry name" value="PseF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03584">
        <property type="entry name" value="PseF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="27466" checksum="1CD8121ABC209DC7" modified="2011-09-21" version="1">MNTSSTSLEASESRPKAVAIITARGGSKRIPHKNVRDFCGKPIISYSIRAALASGVFDEVMVSTDEEAIADVAREYGACVPFLRSAEMAGDYASTDDVIREVLLAYESRGQHFQRFCCIYPTAPFVTAQKLKTAMELLDKAESVMPVVPFSYPPQRGIILENGRVRRKYPEFLTTRSQDLETMYHDCGQFYACCTDAFFRDSTTDVDDLLPMIMPEMEVQDIDTEEDWAIAELKFLHMKDGNLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6G4</accession>
    <name>F7K6G4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251421.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01472"/>
    <dbReference type="EnsemblBacteria" id="EGN41946">
        <property type="protein sequence ID" value="EGN41946"/>
        <property type="gene ID" value="HMPREF0994_01472"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1605"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="28752" checksum="52CB7C6D13438423" modified="2011-09-21" version="1">MINDLVSIVMPVFHAEAFLEKTVEKVQEQTYKNWELIAVDDCSGDGSFELLCRLAEADGRIRPVRQEHNQGAAASRNKGVELAQGRYLAYLDADDLWTKTKLEKELAFLKEKQAAFAFTGYEFGDSDGVGNGKIVHVPETLTYKKALSRTVIFTTTVLFDLQKISKELVCMPQVKSEDTATWWRILRNGYTAYGLDENLAVYRRPAKSLSSNKLEAIRRIWYLYRKQEGLSLFTSLYHFCFWALRAVARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6K4</accession>
    <name>F7K6K4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251463.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01514"/>
    <dbReference type="EnsemblBacteria" id="EGN41988">
        <property type="protein sequence ID" value="EGN41988"/>
        <property type="gene ID" value="HMPREF0994_01514"/>
    </dbReference>
    <dbReference type="GeneID" id="29724685"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1652"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102866_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="13980" checksum="075FB5245F2FFD1B" modified="2011-09-21" version="1">MKKKEAAGVAVYSVVKIVVIILVIMVVYRLGSMAYSYGERIFGEPPMESAPGTDIVITVGSEDSVRDIAENLKAAGLIRDAGLFVLQERLAGYKEGVKAGTYTLNTSMTPEELIQTMAASSDEGDADEDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6K9</accession>
    <name>F7K6K9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251468.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01519"/>
    <dbReference type="EnsemblBacteria" id="EGN41993">
        <property type="protein sequence ID" value="EGN41993"/>
        <property type="gene ID" value="HMPREF0994_01519"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1657"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="164" mass="18810" checksum="578198826CA6FD24" modified="2011-09-21" version="1">MRIMGLDFGSKTVGVAISDPLLITAQGIEIVRRKEENKLRQTLARIEELITEYEVKEIVLGYPKHMNDSEGDRVALTKEFAEKLMRRTALPITFWDERLTTVAADRTMIEAGIRRENRKEHVDRIAAVLILQGYLDYRRNREDGVLEQAVSKEERSGIPMEPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6L4</accession>
    <name>F7K6L4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_01524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251473.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01524"/>
    <dbReference type="EnsemblBacteria" id="EGN41998">
        <property type="protein sequence ID" value="EGN41998"/>
        <property type="gene ID" value="HMPREF0994_01524"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1662"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="4"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN41998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="386" mass="42526" checksum="2822BC4633CCE881" modified="2011-09-21" version="1">MECYLDNSATTQCFDSVAAIMTRVMCQDYGNPSSMHVKGVQAEQYLRYAKDVIARTLKVNEKEIFFTSGGTESDNLALIGCAFANCRAGKHLITTAIEHPAILQTMQYLEGQGFEVTYLPVDRYGRIRLEDLQCAMRPDTILVSIMHTNNEIGSLQPVAEAGMLIKRMNPGTLFHVDAVQGFGKFRILPKKMGIDLLSVSGHKIHGPKGVGFLYINEKVKIQSIIFGGGQQRGMRSGTENVPGIAGLAKACEEMYLNLEGDVNRLYALKEMFIEGVMQLDGVQVNGLTGRDSAPHVISVSFRGVRSEVLLHALEERGIYVSSGSACSSNKPGTAASATLRAIGLDKELMGSTLRFSMSVFTTEEEIRYTLNALYEIVPMLRRFTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6M2</accession>
    <name>F7K6M2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="8" type="ORF">HMPREF0994_01532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251481.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01532"/>
    <dbReference type="EnsemblBacteria" id="EGN42006">
        <property type="protein sequence ID" value="EGN42006"/>
        <property type="gene ID" value="HMPREF0994_01532"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1670"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="7">
        <location>
            <begin position="104"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN42006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="344" mass="38561" checksum="0AE923C728A1E502" modified="2011-09-21" version="1">MQHELDERKMKILQAIIRNYLETGEPVGSRTISKYTDLNLSSATIRNEMADLEELGYILQPHTSAGRIPSDKGYRLYVDSMLEEKDREVADLKELLVEKEDKMDHLLRQVARVLAVNTNYAAMISSPLYHGNKLKFIQLSRVDEHQVLAVIVVEGNMIKNTMLHVEEAPDQETILKLNILLNTHLNGKSLDEINLGMIANLKQQAGIHSDMVGEIIDAVAEAIQADEDLEIYTSGTNNILKYPELADKELAGQLITTFEEKQALNQIVQETLADESSTGIQVYIGNETPVKTMKDCSIVTATYELGEGMKGTIGIIGPKRMDYDKVVGILKNLMTQLDTLYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6X4</accession>
    <name>F7K6X4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-1,6-bisphosphate aldolase, class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251554.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01641"/>
    <dbReference type="EnsemblBacteria" id="EGN42115">
        <property type="protein sequence ID" value="EGN42115"/>
        <property type="gene ID" value="HMPREF0994_01641"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1793"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="287" mass="30509" checksum="5306276E5FD01B70" modified="2011-09-21" version="1">MLVSAKEMLDKAKAGHYAVGQFNINNLEWTKAVLQTAQELNSPVILGVSEGAGKYMCGYKTVVGMVNGMLEEMNITVPVALHLDHGSYEACYKCIEAGFSSIMFDGSHYAIEENVAKTKELVAAAHEKGISIEAEVGSIGGEEDGVIGMGECADPNECKMVADLGVDFLAAGIGNIHGKYPANWKGLSFETLDAIQQLTGDMPLVLHGGTGIPEDMIKKAISLGVSKINVNTECQLSFAAATRKYIEAGKDLEGKGFDPRKLLAPGAQAIKDTVKEKMEMFGSVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K717</accession>
    <name>F7K717_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251373.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01424"/>
    <dbReference type="EnsemblBacteria" id="EGN41898">
        <property type="protein sequence ID" value="EGN41898"/>
        <property type="gene ID" value="HMPREF0994_01424"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1552"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="385" mass="43875" checksum="61DACAD07FEC981E" modified="2011-09-21" version="1">MKKKIMLIVPMLHQGGFERVCVATARLLEPFYEVYIVIFSSRDIAYDIRGLRVIDLHMGAEDGKLRKIRNVFRRSRKVSSLKKELGIDIAYSFGPTANLVNVFSRSSGKTWCGVRSYMDMGNPRLLKLFCSRSDKIVCCSRVIEEEIREKFQCTKTVTLYNPFDIREEQEKAAQEEERMPFQDCGSVIVSMGRQDDVKGFWHLLKSFALLYKKKPEARLLIVGEGDFQEYWKLAEDLKISGAVSFPGVKKNPFPWLNLGSIYVMTSLNEGFPNVLVEAMALGKPVISTNCMTGPAEILMDDFKAYVGKEEYIDGDYGILIPNLDTEKNLDASVITPEEERLAQQMMRLLDSTILYEKYKKASLERAAGFSNEAYAGKLREMAEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7D9</accession>
    <name>F7K7D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251681.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01768"/>
    <dbReference type="EnsemblBacteria" id="EGN41581">
        <property type="protein sequence ID" value="EGN41581"/>
        <property type="gene ID" value="HMPREF0994_01768"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1929"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="25144" checksum="175DF2CAF538DEBB" modified="2011-09-21" version="1">MEILKCDGVRKVYGSGNNQVVALDRIDLTVNKGEFVAIIGASGSGKSTLLHILGSVDQPTEGKVIVEGTDISTMNRTQAAIFRRRKVGLVYQFYNLIPTLTVRKNILMPLLLDKRKPNQEYFQQVIQSLGITDKLEALPNQLSGGQQQRAAIARSLIYRPALLLADEPTGNLDQKNSREIIDLLKLSNRNLKQTILLITHDEKIALEADRIVTIEDGRIISDEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7M2</accession>
    <name>F7K7M2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251829.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01916"/>
    <dbReference type="EnsemblBacteria" id="EGN41321">
        <property type="protein sequence ID" value="EGN41321"/>
        <property type="gene ID" value="HMPREF0994_01916"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2100"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="33517" checksum="29E0ED7C3166F10E" modified="2011-09-21" version="1">MKKNKTMIICFILPCLLTLFIMYLYPVARTLIMSFFRIESVTSDVSTWSFYGLGNYSRIFGSPTYRVSMWNMLRIWLVGGIFTLSFSLLFAVILTSGIRFKKFFRAAIYLPNVISAVALATMWIQYVYNNDYGMLNKLLGALGLNGVKWLGTDTKFWAMLFAFIFGAVGYYMLIFISGIERIPQDLYEAATIDGANKVQQFGKITMPLLKGITKTNITFWSVHTTTFFLWSKMFSPVDTEASTIVPVVYLYDTVFGGKGNANRDAGAGAAVGVVLALIIVVVYFVMNRLLKDDDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K887</accession>
    <name>F7K887_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA_helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01860"/>
    <dbReference type="EnsemblBacteria" id="EGN41265">
        <property type="protein sequence ID" value="EGN41265"/>
        <property type="gene ID" value="HMPREF0994_01860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276055_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000605">
        <property type="entry name" value="Helicase_SF3_ssDNA/RNA_vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00910">
        <property type="entry name" value="RNA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_helicase" evidence="1">
        <location>
            <begin position="197"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1081" mass="127328" checksum="2B54971DD55CD1F3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8M7</accession>
    <name>F7K8M7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scpA</name>
        <name evidence="4" type="ORF">HMPREF0994_02215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ScpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252116.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02215"/>
    <dbReference type="EnsemblBacteria" id="EGN41122">
        <property type="protein sequence ID" value="EGN41122"/>
        <property type="gene ID" value="HMPREF0994_02215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2419"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="31966" checksum="536FC9061370E1A6" modified="2011-09-21" version="1">MAIEVKLQVFEGPLDLLLHLIEKNKVDIYDIPIAEITEQYLDYIRQMQSEDMNVMSEFLLMAATLLDIKCRMLLPKEVNEEGEEEDPRAELVQKLLEYKAYKYMSYELRDMQVDARKNFYKAPTIPAEVAKYKAPVDYEELLADVTLTRLHQIFQTCLKRQEDKVDPVRSHFGRIERDEVNIDAKASYVAGYIKSHKRMNFRELLEDQGSRMDVIVTFLVVLELMKTGAVFVEQESIEDDIIITTKELPEGELEFHGLTSLGEGGGTEAEDVDGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8W4</accession>
    <name>F7K8W4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252230.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02329"/>
    <dbReference type="EnsemblBacteria" id="EGN41236">
        <property type="protein sequence ID" value="EGN41236"/>
        <property type="gene ID" value="HMPREF0994_02329"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2547"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="178" mass="20406" checksum="7F8E5830FF6548C0" modified="2011-09-21" version="1">MATIDLIVLGILKKEALSAYDIQKTVEYRNISRWVKISTPSIYKKVLQLEEKGYISSTIVKEGKMAEKAVYSLTETGNEEFEKLMLDIASKPIYIFLDFNAVIVNLDSLSPERQRQCLDSIEKNVKIIKSYLEDNIERKKDMPEIPETGKAVMQQQYILFQAIETWIASVKEGFGKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8X7</accession>
    <name>F7K8X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD phosphatase, family IIIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252094.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02181"/>
    <dbReference type="EnsemblBacteria" id="EGN41088">
        <property type="protein sequence ID" value="EGN41088"/>
        <property type="gene ID" value="HMPREF0994_02181"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2386"/>
    <dbReference type="eggNOG" id="COG2179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PTHR19288:SF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="170" mass="19426" checksum="E71F0F34A370D076" modified="2011-09-21" version="1">MFEKFYPDSYVESAYVIDYEGLYKKGYRGIIFDIDNTLVPHGAPADERSIALFRRLKAIGYECLLLSNNKEPRVKMFNDAVHVHYIFKAGKPGVKNYEKAMDIMGTDDVNTFFVGDQLFTDVWGARNAGLYSFLVKPINPKEEIQIVLKRYLEKIVLHSYKKKLAAGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Z0</accession>
    <name>F7K8Z0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">HMPREF0994_02273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252174.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02273"/>
    <dbReference type="EnsemblBacteria" id="EGN41180">
        <property type="protein sequence ID" value="EGN41180"/>
        <property type="gene ID" value="HMPREF0994_02273"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2481"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="150" mass="17142" checksum="034DFE7E4142E0CA" modified="2011-09-21" version="1">MATRQLRYNQDPILRKRCKEVKEVDDRIRLLLDDMLDTLHHTENGAALAANQVGILKRLVVIDYYDNLLKLVNPRIMESSGTQICVEGCLSFPDRFVKTIRPQKVTVKALNEYGEEIIITGEDEMAKCLCHEIGHLNGEIFLDKAIEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K913</accession>
    <name>F7K913_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252243.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02342"/>
    <dbReference type="EnsemblBacteria" id="EGN40999">
        <property type="protein sequence ID" value="EGN40999"/>
        <property type="gene ID" value="HMPREF0994_02342"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2563"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="488" mass="55952" checksum="F3114206CE2C1BDA" modified="2011-09-21" version="1">MGKEKKRKNIVLLMTDQLRGDCMGCAGHPDVKTPYLDTLASKGIRFPNAYSACPSCVPARAAMHTGLTQESHRRVGYSDGIPWNYPSTMAGELTKAGYYTQCVGKMHVDPLRNYLGFCNVELHDGYLHYYRDPDIPYRENQKQADDYFHWLKQEKGIDCDVTDTGLECNSWVARPWIYEEKYHPTNWVTDRSIDFLRRRDPDMPFFLFASYLRPHPPFDAPQCYFDMYSGKELTPPAIGDWCDDEALRERGRIFDSDTGPLDPELVRQMQIGYYACVTHLDHQIGRLLQALIENKLYEDTIILFVSDHGELLGDHHLFRKSRAYQGSSRIPFIISGGGAAQGRAGRVSRELVELRDVMPTVLEAAGVAVPDSVEGISLWDMVQTENGFVDREYLHGEHALGAASSHWIVTRLEKYIWYSQTGEEQYFRIGTDENELHNLVHDELYQDRVVKLRELLIHELEGREEGFVKDGRLVTGCEPIVWLTKDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9A9</accession>
    <name>F7K9A9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02457"/>
    <dbReference type="EnsemblBacteria" id="EGN40856">
        <property type="protein sequence ID" value="EGN40856"/>
        <property type="gene ID" value="HMPREF0994_02457"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2691"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="106" mass="11601" checksum="B6B9DA89A1C0FCE1" modified="2011-09-21" version="1">MGILASEAATAGTGSMIGVILMYVVIFGVFFYFVMYRPQKKEQKKMNTMLSSLEIGDSILTSSGFYGVVIDITDDTVIVEFGNNKNCRIPMQKSAISQVEKANADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9G0</accession>
    <name>F7K9G0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252421.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02520"/>
    <dbReference type="EnsemblBacteria" id="EGN40919">
        <property type="protein sequence ID" value="EGN40919"/>
        <property type="gene ID" value="HMPREF0994_02520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2763"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066413_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="255" mass="27440" checksum="DD7C89860FE051B5" modified="2011-09-21" version="1">MRGWKLVWKVLWPVLWYLGVMGAAALLCPRRFSVLEVAGVAAGAAAVTLLLGGRLYRGRGFWENLGSGGKALGYGWLLIPAGIAVCIMLNGLLILFGLESTSGMYDGRAEMIYASRMWEQLLISCVLIPFAEELVFRELGFGRLRKECGPALAAGITAVLFGIYHLQLVQGLYAVCLGLLLAAAYEKCGGLGAAFLVHAVSNLTAVVLSLEGEKSWLWGKSLFVVSATLISGLILILCVRKMLKAEGTETKTLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9H1</accession>
    <name>F7K9H1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_02532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252433.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02532"/>
    <dbReference type="EnsemblBacteria" id="EGN40931">
        <property type="protein sequence ID" value="EGN40931"/>
        <property type="gene ID" value="HMPREF0994_02532"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2777"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="40"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="367"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="400"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="607" mass="66581" checksum="B949B72AF2AF730B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9U5</accession>
    <name>F7K9U5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02628"/>
    <dbReference type="EnsemblBacteria" id="EGN40611">
        <property type="protein sequence ID" value="EGN40611"/>
        <property type="gene ID" value="HMPREF0994_02628"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2883"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="144" mass="15878" checksum="733D469FF5C07C80" modified="2011-09-21" version="1">MSGTGTAWFAIVLVCSWQSIAMNTIIYISGLQTVPEDVYEAGAIDGVSGWKKFWSLTFPLIIPFFSINMVLCMKNFLMVFDQIMALTKGGPAQSTESISYLIYNNGMSGGQFGFQSANAFVFFIVIVAISVIQMRITGKKEEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA13</accession>
    <name>F7KA13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02696"/>
    <dbReference type="EnsemblBacteria" id="EGN40679">
        <property type="protein sequence ID" value="EGN40679"/>
        <property type="gene ID" value="HMPREF0994_02696"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2950"/>
    <dbReference type="eggNOG" id="COG2720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660203_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="416" mass="45189" checksum="0299BAF2ADDE7C81" modified="2011-09-21" version="1">MYDILLKINSQRIGVFAKGRYSVMKRHQWKPLLLICLLLAAPVSAAAAMPIPVSAAEALPAGGITTTISDSRYIDAGWMNQNIILTLDGQVWAMGINTMKDYPVFLSNDTGIPQCILGETEVIDVFLNAINEQLKTQIFQSDSPVFDTGTGSYIYNSGQTYYQLNANVKNWLITSLQQQFAAGSPQPLTLELSSGYLTSVVNEGVLTYSPDFVLAGSCTTSFSGSSSNRITNIKVAAEHLNNMIIMPGQEVSVSTAILPRTSANGYREAGAYLNGETVMAIGGGICQVSSTTYNAVKNAGLVVLERHPHSMPVHYLPLGLDAAISSGSKDLRFRNNYSAPVILQAYTEGKKLIINVLVWDHDLNGRSFKLWAKNTGSLSAKTYFTTYQDGKEVSTDYVGNSTYMAPKPKNTEAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA50</accession>
    <name>F7KA50_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252637.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02736"/>
    <dbReference type="EnsemblBacteria" id="EGN40719">
        <property type="protein sequence ID" value="EGN40719"/>
        <property type="gene ID" value="HMPREF0994_02736"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HAK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1633280_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="162" mass="18172" checksum="6A457C36174CB75B" modified="2011-09-21" version="1">MEMNDRTEQAEELWDDLPTDSQHETLWEAEGTELAVRQLMDQLKASEEKQQGLMKKQLLFTRIFAVSNCVLVLLVLIFVAGVLPRLTTALDKATESLVKVDGALDDFGKVFDNVNSLVDSSSKAVEQTMDKVDQMDIESLNNAISDLNDVVAPMAEFFGRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAN9</accession>
    <name>F7KAN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rod shape determining protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252766.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02865"/>
    <dbReference type="EnsemblBacteria" id="EGN40474">
        <property type="protein sequence ID" value="EGN40474"/>
        <property type="gene ID" value="HMPREF0994_02865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3134"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="370" mass="41220" checksum="FFE15F62A9F28030" modified="2011-09-21" version="1">MLKRYKLRNYDFKLVLLVLAISIIGIMAVGSAKESLQERQIAGVAMGMVIMIIISLIDYSQLLRLYWFYYIFSIGMLIAVLIWGEKVNGATRWINIPHLFQFQPSEIAKILLILFYAQFIMKYKEKLNTFKILFLCVGLMLPAIFLVYKEPNLSTTILYCILFCVLIFVGGLNYKIIGGVLAVIVPSLAVAFYLVMQPGQQLIQNYQLTRILAWLNPEKYADAEAYQQLNSVMAIGSGQLWGKGLNNNVIASVKNGNFISEPETDFIFAVIGEEMGFVGSCVVIVLLMLIALECISIARTAKDTSGMIIASGMAAVIGFQSFMNIAVTTMIMPNTGIPLPFVSNGLTSLVSLFIGMGFVLNVRLQRKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAU5</accession>
    <name>F7KAU5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40352">
        <property type="protein sequence ID" value="EGN40352"/>
        <property type="gene ID" value="HMPREF0994_02974"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2167692_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="110" mass="13010" checksum="C740BCD44D3FBCD2" modified="2011-09-21" version="1">MREQGICLMALKWSNSKMDWPKPVRLLIFRLRRRVETVFFQLSEQLNAERVHAKNFQGLCCTRLVNKVLAYNLCLALNYMLDENREIGKIKTAHLLIQYSHKTTRGLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAV3</accession>
    <name>F7KAV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252883.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02982"/>
    <dbReference type="EnsemblBacteria" id="EGN40302">
        <property type="protein sequence ID" value="EGN40302"/>
        <property type="gene ID" value="HMPREF0994_02982"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3258"/>
    <dbReference type="eggNOG" id="ENOG502Z8PZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067295_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="279" mass="32907" checksum="1E63DB5A3527CD26" modified="2011-09-21" version="1">MFGYVIVNKQEMKFKDFEVYQSYYCGFCQELKKRYGVKGQITVTYDMTFLILLLKGLYEVEDKVDGCKCIAHPFDRHPTRANTFTEYAADINILMTYYQCMDDWEDEKKVWKRGYAGILKRAFGEAAARYPKKAEEISGQMQLLHECEKKNEKNLDIVAGCFGNIMAEIFALKNDEWEEELRKMGFFLGKFIYLMDAYEDIEKDRKKGNFNPFLSMCGENGFDDEVYHILRMMMAECSRAFEKLPVLQNVDILRNILYSGVWCRYEMVKGKRKEQQENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAV5</accession>
    <name>F7KAV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252885.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02984"/>
    <dbReference type="EnsemblBacteria" id="EGN40304">
        <property type="protein sequence ID" value="EGN40304"/>
        <property type="gene ID" value="HMPREF0994_02984"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3260"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="198" mass="22568" checksum="427D315A8FBD08E4" modified="2011-09-21" version="1">MSKDFRNSETKDNLMRAFAGESQARNRYTFAASQARKDGLHVIEAVFTFTANQEKEHAEIFYNHLKELSGETIVVDGGYPVDIYPDVKQLLLSAQHNEYEEYDPIYKVFGDKAKEEGFDKVAASFHMISAIEKTHGDRFGKFAQLMEQNKLFISDVETGWICLNCGYVYTGTNAPEKCPVCDHDKGYFIRLSMSPFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB59</accession>
    <name>F7KB59_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="10">RNAP omega subunit</shortName>
            <ecNumber evidence="2 10">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpoZ</name>
        <name evidence="11" type="ORF">HMPREF0994_03095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 10"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252996.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03095"/>
    <dbReference type="EnsemblBacteria" id="EGN40272">
        <property type="protein sequence ID" value="EGN40272"/>
        <property type="gene ID" value="HMPREF0994_03095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3384"/>
    <dbReference type="eggNOG" id="COG1758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153189_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="81" mass="8948" checksum="A968E61916AA02F8" modified="2011-09-21" version="1">MLHPSYTDLMKVVNSDVEPGETNIVNSRYSIVMATSKRARQIIGGDEPLVNMKTGMKPLSVAVEELNEGKIKILGDEETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB68</accession>
    <name>F7KB68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage 0 sporulation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253008.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03107"/>
    <dbReference type="EnsemblBacteria" id="EGN40284">
        <property type="protein sequence ID" value="EGN40284"/>
        <property type="gene ID" value="HMPREF0994_03107"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3397"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072509_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012052">
        <property type="entry name" value="Spore_0_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02875">
        <property type="entry name" value="spore_0_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="175" mass="19718" checksum="97BE4149AAEE2B11" modified="2011-09-21" version="1">MEQLRMSAGKDNERVVQILTDLMKTNKEFQIMITVPASGASSLSEMAKEEETAVKPAAAHNLEKDVTDMIHEIGVPAHIKGYQYLREAIMMSVEDIEMLNSITKILYPTIAKKYQTTPSRVERAIRHAIEVAWSRGKMETLDSLFGYTINTGKGKPTNSEFIALIADKIRLQYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBB7</accession>
    <name>F7KBB7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253047.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03146"/>
    <dbReference type="EnsemblBacteria" id="EGN39976">
        <property type="protein sequence ID" value="EGN39976"/>
        <property type="gene ID" value="HMPREF0994_03146"/>
    </dbReference>
    <dbReference type="GeneID" id="29729002"/>
    <dbReference type="eggNOG" id="ENOG50327UI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2493932_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="86" mass="10029" checksum="03E57BF04CA56EE0" modified="2011-09-21" version="1">MLDEITDCAVSGWLQDVFLKDEEYQKLGEEEKKAAVECYRRLPEEYHNVVEQLMDCHNSCCGKLIDLAYKQGMIDCAQLLRELKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBF1</accession>
    <name>F7KBF1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253086.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03185"/>
    <dbReference type="EnsemblBacteria" id="EGN40015">
        <property type="protein sequence ID" value="EGN40015"/>
        <property type="gene ID" value="HMPREF0994_03185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3479"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067347_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="33555" checksum="61CD1EAF6B02B191" modified="2011-09-21" version="1">MSWLDLHMHSQISLDGEFSPERLAEICHDSGLKVVALSDHNSVRGVERMMTACSRFGIREIPAVELDCIFEGVDLHLLGYGIDFQDPRYRELEEDILSQKKKNSSEVMKILKDTGIFFEEEKVLAMSRDGVVVGETIAEAALADDRNSENPLLAPYREGGERSDNPYVNFFWDYCSQGKTAYLPVSYPPFEEAQKLIADTGGISVIAHPINTVGRSRERISAMKEKGAAGLEVYSSYHKKEDVEWFHKLAEELGMLETMGSDFHGKTKPSVIPGGTGGDQKEEKSLSLLDYLLKMHRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBL1</accession>
    <name>F7KBL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253148.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03247"/>
    <dbReference type="EnsemblBacteria" id="EGN40077">
        <property type="protein sequence ID" value="EGN40077"/>
        <property type="gene ID" value="HMPREF0994_03247"/>
    </dbReference>
    <dbReference type="GeneID" id="29728459"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3547"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250671_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363643" evidence="3">
        <location>
            <begin position="30"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="1332"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="1398"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1462" mass="157521" checksum="185CA5B33FA3E8B0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBQ5</accession>
    <name>F7KBQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate formate lyase activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253194.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03293"/>
    <dbReference type="EnsemblBacteria" id="EGN40123">
        <property type="protein sequence ID" value="EGN40123"/>
        <property type="gene ID" value="HMPREF0994_03293"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3601"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="72"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="291" mass="32547" checksum="CE6C4F9823CD6A81" modified="2011-09-21" version="1">MERRDSVKESRGCSAEEQEIICPVCMHHCRLRPGQTGSCRARANRGGVSSSLSYGRITSLALDPIEKKPLAMFEPGSRILSVGSYGCNLSCPFCQNYEISMCTADAETIRLSPEELAGKAAELKEKGNIGVAFTYNEPMIGYEYVRDTARIVRSAGMKNVVVTNGSVTEEILEEVLPFVDAMNIDLKGFTEDFYRKLGGDLETVKRFIRRAAASCHVELTTLIIPGENDTPEQMRELSAWTAGIDRNIPLHVTRFFPRWKMTDRPPTRVRTVYELADIARERLAYVFTGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBT5</accession>
    <name>F7KBT5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase_S11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_03332</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253233.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03332"/>
    <dbReference type="EnsemblBacteria" id="EGN40162">
        <property type="protein sequence ID" value="EGN40162"/>
        <property type="gene ID" value="HMPREF0994_03332"/>
    </dbReference>
    <dbReference type="GeneID" id="29728942"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3643"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_7_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356790" description="Peptidase_S11 domain-containing protein" evidence="11">
        <location>
            <begin position="28"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="12">
        <location>
            <begin position="81"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN40162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="500" mass="55551" checksum="2D6121192CD7D887" modified="2011-09-21" version="1">MKYKWKPVTAVILSSFILFSSPMNVFASGNTISTIEDEMVHNTEGGEETAAGQETETGEREAEQENTGESGEDGSDIFWPSGPSVVAESGIVMEVSTGTILYSKNMHARYYPASITKIMTALLAMENCELDEMVTVPHEAVYMDDKGSHIALDEGEELTVEDCLYGMMLASANDAAYALAVHVGGTIENFADMMNKRAKELGCQDSNFVNPHGLPDERHVSSAYDMALITREALKHEIFRTVSKTVYYEIQPTDKQPDLIPMSNHHKMLCSGKYHYDGVFAGKTGYTVVAKNTLVTCAARDDMELICVTMKTEGRQVYVDTASLFDFCFDNFKKVDIGTSEAAEIQVPVKAADGTEKVETVPVQMAEDGFVIIPSRVNFSELKPQLLLAAEAERGETGTLEYTYGTHQVGQASINLPDFLKVKEEPAETETETESQPAKEEKDGKAGFHWWYIPLGILAAAVIVTGAVMLVRRQIWKYRWRKRRRSGRTRDYSGGRRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBY7</accession>
    <name>F7KBY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03329"/>
    <dbReference type="EnsemblBacteria" id="EGN40159">
        <property type="protein sequence ID" value="EGN40159"/>
        <property type="gene ID" value="HMPREF0994_03329"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3640"/>
    <dbReference type="eggNOG" id="ENOG502ZBVK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084422_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045751">
        <property type="entry name" value="DUF6179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19677">
        <property type="entry name" value="DUF6179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="318" mass="36233" checksum="527B60E56991EC4E" modified="2011-09-21" version="1">MVAYALVFGADRQVWRKTLPDCFLIQYRRKACGMRGIDMENERTAGYELEELLPVAAWLTDKYTSKESSSVTYETASALMEAVCYCIQECFSQNTNGILSAEKGIHARQAYEKGYLNVLEKAGKAKELYEKLIVDFEDYGCLNYRETIIKGLPAFFMKYDARFRPQDHILTLDYPDLLPGEPLSGVDRIYSYLLHITMEKKLLEQFPRQAVCGLLESLQPDYKNLYMDNICYPVLLHALICMVGDCPVRELQAGREEKKLLRIYLEGDSLDKAAEKVKALLGMLVSQMTGMGQEEQDYFAGMGRELAVRMMQAAKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCQ7</accession>
    <name>F7KCQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253537.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03636"/>
    <dbReference type="EnsemblBacteria" id="EGN39008">
        <property type="protein sequence ID" value="EGN39008"/>
        <property type="gene ID" value="HMPREF0994_03636"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3968"/>
    <dbReference type="eggNOG" id="COG2368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376276_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="729" mass="83697" checksum="F5FD6AD56B05B4CE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCW4</accession>
    <name>F7KCW4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253594.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03693"/>
    <dbReference type="EnsemblBacteria" id="EGN38857">
        <property type="protein sequence ID" value="EGN38857"/>
        <property type="gene ID" value="HMPREF0994_03693"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4031"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="32650" checksum="A8E8683D7AFD64FE" modified="2011-09-21" version="1">MGKILITGATGNVGRYTAEYLLGAGEEVKAASKNKDKVTKLFGNAAEYCEFDFQRPETFDGALKETDRVFLMRPPQMGNPEELYPFLDTVKKKGDIRLVVFLSLQGAEKNPMPPHHKIEKYMIHTGLPYCFMRPGFFMQNLSGVHAFEIKYFDRIVVPAGKSLTGFIDARDIGDISGMVLSRPEGHEEKAYEITGPEAIDYYKAAEILSQELGRKITYTEVSPGKALYYWTHIRGLDEEYSKVMNMLYRLTRMGMAKTVTDDFEKITGRKARSFQEFVRENRESWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDR8</accession>
    <name>F7KDR8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253898.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03997"/>
    <dbReference type="EnsemblBacteria" id="EGN37686">
        <property type="protein sequence ID" value="EGN37686"/>
        <property type="gene ID" value="HMPREF0994_03997"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4354"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="411"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN37686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="513" mass="59453" checksum="045CFC9EB10B9606" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDU4</accession>
    <name>F7KDU4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">HMPREF0994_04023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253924.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04023"/>
    <dbReference type="EnsemblBacteria" id="EGN37712">
        <property type="protein sequence ID" value="EGN37712"/>
        <property type="gene ID" value="HMPREF0994_04023"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4384"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_0_1_9"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN37712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="224" mass="25000" checksum="A06A206FD567BC24" modified="2011-09-21" version="1">MEAYKSEFIDFMIESDVLKFGDFTLKSGRKSPFFMNAGAYVTGTQLRKLGEYYAKAIHDNYGLDFDILFGPAYKGIPLSVATTMAISELYGKDIKYCSNRKEVKDHGDTGILLGSKIKDGDRVVIIEDVTTSGKSIEETFPIIKAQADVEIKGLMVSLNRCERGKGEKSALQEIQELYGFPANAIVSMEEVVEYLYNRTHDGKIIIDDAMKASIDAYYAQYGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDY2</accession>
    <name>F7KDY2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37097.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360322.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04061"/>
    <dbReference type="EnsemblBacteria" id="EGN37097">
        <property type="protein sequence ID" value="EGN37097"/>
        <property type="gene ID" value="HMPREF0994_04061"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="215"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN37097.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="433" mass="48340" checksum="1247A6F2D44BB158" modified="2013-09-18" version="2">MFRQVHRRLTFLCAGITILVLILMSCSYLYISEKNLRESSFTSFQNDMNTLLSNLENQTVITHEWLSKMEGNGKYLLSLRDNGQDFLWGRQEHDPAYREAIDAGWNYYDANSGGFPSAQPFTIRHQEFSFSSSGGKNDDYYGCIAFSSRDTGTLTILILRSMGNLQERIQTQRNSFLILIVTASLVLAFFSYLFTGLLLKPLKKSRQSQIEFVAAASHELRTPLSVILSASNACRKAPPEEQGMFFDIIKKEGDAMSGLISDLLTLAGADSHSFTIRAASCEPDTLLLDTFEAFELLAREKGYHLSIQLPEEKTTPVFCDSDRIRQVLSVLLHNAFSFCPSGSRITLSLSQQDKITSISVADNGPGIPDDRKAHLFDRFYRGDSSRQDTGHFGLGLSIAREIMDAHHGSLTVSDTPGGGSTFTLILNNYRKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE33</accession>
    <name>F7KE33_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04112"/>
    <dbReference type="EnsemblBacteria" id="EGN36905">
        <property type="protein sequence ID" value="EGN36905"/>
        <property type="gene ID" value="HMPREF0994_04112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766799_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="361" mass="40101" checksum="4A1B74A1001C04E2" modified="2011-09-21" version="1">MKILLAENIRFFRKASGLTQEQLAEAMDVTVGAVSKWESGATTPDLSSILELAALFAVSVDVLLGYQLQNTDARQLAEKIHSLMLDKSYEEALRESQKALSKYPNHFDIVYRSADLYHTVGMERRNHELLHQARGLLEHSLRLLDQNTNAQIDEAVIQIQIAKLYAAAGETDRAIAHYKKHNYAGINNGRIGALLSSAGCYEEAQPYLSASALDQITELIQVTTGMSACAAQTGSPSEAFQVLSWMRQILDGLKIPGKVCYLDKADVFLLHLQAQLYADAGDLPAAKDCLQKAVRTARRFDAAPVYTMKNIRFYHEKDPLLLSDSFGETAMQGLENSILHGTAEGTQILREIWREIINESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE48</accession>
    <name>F7KE48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254028.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04127"/>
    <dbReference type="EnsemblBacteria" id="EGN36920">
        <property type="protein sequence ID" value="EGN36920"/>
        <property type="gene ID" value="HMPREF0994_04127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_21_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="154" mass="18040" checksum="4E2C5D4F4200AF18" modified="2011-09-21" version="1">MIRKFDEKDLHAVMELWLESNIEAHDFIDSRYWKENYSKVEEMLPQAEIYVYEEAKKIAGFIGLTGNYIAGIFVGKSCRSNGIGRRLLDYVKAERETLTLQVYEKNRRAVGFYKREGFYMVQEQTEEGTGEKEFLMEWKKENGNKNKKNGSVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEG3</accession>
    <name>F7KEG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254147.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04246"/>
    <dbReference type="EnsemblBacteria" id="EGN36526">
        <property type="protein sequence ID" value="EGN36526"/>
        <property type="gene ID" value="HMPREF0994_04246"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_17_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="141" mass="16230" checksum="2116954DABC3647A" modified="2011-09-21" version="1">MVITPNFHFHGDCEDAMKLYQKAFSGEITCLLRYQDANPQDYVADSRWGSRIYHGEMLLYGIRVMMSDLEPAEAENKPESPPLSLVVTMDTKEQVMEAYQAMMEGALIREQPQSTTYSSCFVSLVDRFGIRWEIMTEQTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KES8</accession>
    <name>F7KES8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254258.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04357"/>
    <dbReference type="EnsemblBacteria" id="EGN35667">
        <property type="protein sequence ID" value="EGN35667"/>
        <property type="gene ID" value="HMPREF0994_04357"/>
    </dbReference>
    <dbReference type="GeneID" id="29725813"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4757"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020573_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028212">
        <property type="entry name" value="GHL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14871">
        <property type="entry name" value="GHL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="704" mass="80687" checksum="6A93A8EA7C590746" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEU8</accession>
    <name>F7KEU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt/nickel transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254282.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04381"/>
    <dbReference type="EnsemblBacteria" id="EGN35691">
        <property type="protein sequence ID" value="EGN35691"/>
        <property type="gene ID" value="HMPREF0994_04381"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4780"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN35691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="31689" checksum="8A389EC1943BA4CC" modified="2011-09-21" version="1">MARLLTYAPKNTWIHRLSGVTKMLFFVLWSIAGMLTYDTRVLAVMLAISLLIFKVSKTEWKQVGTVFKFILFFLFLNLITVFLFSPYQGTEIYGTKTVLFHIAGRYSVTTEQLFYEFNIMLKYFTVVPVVLMFMVTTNPSEFAASMNRLGISYNVGYAIAIALRYVPDVQSDFTKIKHAQEARGIEMSNKASIFKRLKNMANIIFPLIFSSMDRIDVVSNAMELRGFGKKKKRTWYMGKPLERNDYLTLAFVVCFVAAALVITFHDGNRFFNPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEX4</accession>
    <name>F7KEX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04410"/>
    <dbReference type="EnsemblBacteria" id="EGN35720">
        <property type="protein sequence ID" value="EGN35720"/>
        <property type="gene ID" value="HMPREF0994_04410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4814"/>
    <dbReference type="eggNOG" id="COG4709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080365_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="190" mass="20683" checksum="449894D3CC64C06F" modified="2011-09-21" version="1">MNALEKRLRILPKENFNEAMDYFTEYFEDAGPEREQQAIQDLGSPDTAAEQIITNMAIHKASVPQKGLRRNMNALWIGILAVCAVPIALPFALMLLCVLIMFLLCILMVLAALAMAAFAFLICGPVAVAASFTVLFTAPATAISCLGAGLFCTGLGLLAVYGVFQLCRYVLINLVRLFGNILKKKGERHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEX5</accession>
    <name>F7KEX5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254312.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04411"/>
    <dbReference type="EnsemblBacteria" id="EGN35721">
        <property type="protein sequence ID" value="EGN35721"/>
        <property type="gene ID" value="HMPREF0994_04411"/>
    </dbReference>
    <dbReference type="GeneID" id="29724872"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065323_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363956" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="71"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="360" mass="39160" checksum="93406AD670E1971E" modified="2011-09-21" version="1">MRKRNKFFISCAVLCAAGLLLSVLGWVFGGRFNGIGYQPGKGLTVFSANSYGNSENGPSVLSDTINDLEAFTSLDIKIDYADISIQPSDHYGVEYQLVAWNPPVIQVKDGQLMVRDGKRNNSSPVMFLSGFNMTFSGNWPSAKEYVTVYVPAETYFTTLNVSTSSGATKISGLQAKELTMVNDYGDVSLSDISCTNMDMKLSSGKFKAENLNGESLKVSNDYGDCSLDNSAITAVTDLSLSSGKLKISNSSLGQFSADSDYGDVDLNEISASDASLKLSSGNMTADAFLFSNLTVKSDYGYVDIAPASSESYGYDLKTDYGEIKVADHKLGEVYYTFEKEYKNWIRVECSSGDIIIRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF10</accession>
    <name>F7KF10_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254352.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04451"/>
    <dbReference type="EnsemblBacteria" id="EGN35761">
        <property type="protein sequence ID" value="EGN35761"/>
        <property type="gene ID" value="HMPREF0994_04451"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4861"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="196"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="37007" checksum="D38BAB89C4E2DDC4" modified="2011-09-21" version="1">MPQTIEYEEKHFIIINDIENSLFYFFDFDVRSTEKNMEFEHLHSYYEIHILLSPMATHFIEGIPYRIRTNDFVLLEPSRLHKSFYPSDTPSKRLVITFMYRDDGYGFKDTYENLLTPFRDTVPIFRFPESQQEVLVRILNEIVALSRQAGAQEMTGAYELMVHSLFTQFLYYLKAFHDYNMYETENPQDRLSERIYTVANHIHTHYMDNLTLEGLAKSIYMDPFYLSHQFREVTGYTITQYIHLVRIRNCQFLLLNTEDKITDISSACGFTSFSQFNRVFHKFCNESPSEYRKSQSTGRLLVERPKPLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF36</accession>
    <name>F7KF36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254379.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04478"/>
    <dbReference type="EnsemblBacteria" id="EGN35788">
        <property type="protein sequence ID" value="EGN35788"/>
        <property type="gene ID" value="HMPREF0994_04478"/>
    </dbReference>
    <dbReference type="GeneID" id="29724746"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125405_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="135" mass="15314" checksum="BA6578F1E15ABAB9" modified="2011-09-21" version="1">MKYEFEVYQMQVEDHLFWVARSKILKGCLGQGDTAEDAIKELEINEEEWIDTATVCGIPVPAPTVHSQYAYSGKVSLRFSPFTHEEASNNAKALNISLNQYINDAIVYYNALNKNKSQLQRELFESEGSLHLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF60</accession>
    <name>F7KF60_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose 6(F)-phosphate phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.329</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + sucrose 6(F)-phosphate = alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:38863"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57723"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.329"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 13 family. Sucrose phosphorylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.329" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254403.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04502"/>
    <dbReference type="EnsemblBacteria" id="EGN35812">
        <property type="protein sequence ID" value="EGN35812"/>
        <property type="gene ID" value="HMPREF0994_04502"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4915"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021358_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044262">
        <property type="term" value="P:cellular carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11355">
        <property type="entry name" value="AmyAc_Sucrose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016377">
        <property type="entry name" value="Sucrose_GGa_phosphorylase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022527">
        <property type="entry name" value="Sucrose_phospho"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003059">
        <property type="entry name" value="Sucrose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03852">
        <property type="entry name" value="sucrose_gtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="7"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="292"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="336"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>sucrose</name>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR003059-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR003059-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN35812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="56057" checksum="F1E49BE98BF47C15" modified="2011-09-21" version="1">MKTLENKCMLITYSDSMGHNLMDLERVLSTYFKDAVGGVHILPFFPSSGDRGFAPMDYTRVDPAFGGWEDVEKLADKYYLMFDYMINHISAQSEYYKDFLEKKDASRYRDLFIRYKDFWEGGEPTEEQVDVIYKRKPRAPYVDAHFADGTVEKVWCTFDEEQIDINCKSETAKEFIRDNLTGMCRHGAAMIRLDAFAYATKKAGTSCFFIEPDIWELLDECTEILKPYHVEILPEIHEHYTMQKKIEEKGYYVYDFALPMLLINALYYGQTGYLKKWLEICPRKQFTTLDTHDGIGVVDVKDLLPDEEINRTKEDIFKYGANVKKIYNTAAYNNLDIYQVNCTYYSALGDDDKVYLLARAVQFFAPGIPQVYYVGLMAGKNDLKLLEETKVGRNINRHYYTEEEIAEEVKRPVVEKLIKLMEFRNSFPAFDDSFEIKDCEDGRLVIVRKSNGYTAQLDADFGTKEFVVYTTTPDGEKNKLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFF5</accession>
    <name>F7KFF5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 33 homolog</fullName>
            <shortName evidence="6">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hslO</name>
        <name evidence="7" type="ORF">HMPREF0994_04584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSP33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254485.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04584"/>
    <dbReference type="EnsemblBacteria" id="EGN35031">
        <property type="protein sequence ID" value="EGN35031"/>
        <property type="gene ID" value="HMPREF0994_04584"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5003"/>
    <dbReference type="eggNOG" id="COG1281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054493_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="31807" checksum="E3D08FBE010A28F5" modified="2011-09-21" version="1">MKDYLVRATAADAQIRAFAATTRQMVETARQKHDTSPVVTAALGRLLTAGSMMGSMLKGEEDLLTLQVTGDGPMGGMTVTADSKGHVKGYANEPQVILPANSQGKLDVGGAVGSGILRVIQDSGLKDPYVGQTVLQTGEIAEDLTYYFATSEQVPSSVGLGVLMERDNTVRQAGGFIVQLMPFAEEETISRLEQNLGKIRSVTSMLDEGLTPEELLGLVLEGMDIQFRDTCEVEFSCSCSKERVEKALISIGREEIDKMIADGEPIEVKCHFCNKGYQFSVQELEEIVEKCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFT7</accession>
    <name>F7KFT7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin reductase</fullName>
            <ecNumber evidence="1">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254617.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04716"/>
    <dbReference type="EnsemblBacteria" id="EGN34642">
        <property type="protein sequence ID" value="EGN34642"/>
        <property type="gene ID" value="HMPREF0994_04716"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5148"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="32551" checksum="D82A033242B89ECC" modified="2011-09-21" version="1">MKKELYDVVIIGGGPGGYSAALYCARNGYSVLVLEKLSAGGQMATTGQVDNYPGFDEGIDGFELAEKMQRGAERFGVETEYAEVNSVDLSPAIKKITTSSGIVSARSVIVATGASPRELGLPEESSLRGRGVAYCAACDGQMYRSKTVAIAGGGNSAAADALLLSKICAKVYLVHRRDSLRASRIYMEPLKNSGVEFVWDSKITEILHDKRVSGIRVENVKDKTTKEIPVDGVFVAIGRVPDTGLFKGQLDLDPHGYIIADESTRTNIEGVFAVGDVRTKALRQIVTAAADGANASHYIEEYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFX8</accession>
    <name>F7KFX8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04757"/>
    <dbReference type="EnsemblBacteria" id="EGN34683">
        <property type="protein sequence ID" value="EGN34683"/>
        <property type="gene ID" value="HMPREF0994_04757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406989_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="PTHR41878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="675" mass="78107" checksum="16701FE670986FC8" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG26</accession>
    <name>F7KG26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04805"/>
    <dbReference type="EnsemblBacteria" id="EGN34432">
        <property type="protein sequence ID" value="EGN34432"/>
        <property type="gene ID" value="HMPREF0994_04805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5248"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356868" evidence="2">
        <location>
            <begin position="34"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="572" mass="63212" checksum="6A27826707F1272A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG73</accession>
    <name>F7KG73_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254757.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04856"/>
    <dbReference type="EnsemblBacteria" id="EGN34483">
        <property type="protein sequence ID" value="EGN34483"/>
        <property type="gene ID" value="HMPREF0994_04856"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006325_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="771"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="838" mass="94738" checksum="A76E76BEB3AFCC63" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGA8</accession>
    <name>F7KGA8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04865"/>
    <dbReference type="EnsemblBacteria" id="EGN34492">
        <property type="protein sequence ID" value="EGN34492"/>
        <property type="gene ID" value="HMPREF0994_04865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5308"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="292" mass="32986" checksum="652137144853768D" modified="2011-09-21" version="1">MRKTWGSRMQIGLLLLPGVLIFGIFTLYPIAKLLIMSFFKWDFGSILNQEFIGFANYGEVFRDPYFHTVFVNSIVYTLVTVPAQMLLGLLTALFINSIGHFRIGFRVLYYLPVITSWVIASLVFKYVFNTEGMLNYFLTDIIHVTSRNIRWLDTRWGGLTIAMLLGIWKGIGWNMVVFLAALQTVPQELYEVASLDGAGSVRKFFSVTLPSIRGTVLFALVMLTIGGFNVFTSIKMITDGAPGHQTDTILTWMYYKAFSTGKFGYSAALSFITAVVLAILALFQFRLMRSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGC0</accession>
    <name>F7KGC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254800.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04899"/>
    <dbReference type="EnsemblBacteria" id="EGN34189">
        <property type="protein sequence ID" value="EGN34189"/>
        <property type="gene ID" value="HMPREF0994_04899"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5349"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="272"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="394" mass="40820" checksum="99452D6CA2BBDACA" modified="2011-09-21" version="1">MSRKVVLAGGCRTAIGVMGGALSTVPAADLGTIVIKEAMNRAGITPDMVDEVYMGCVIQAGQGQNVARQAAVNAGIPVEVPATTINVLCGSGLHCVNLAAKLIASGDADIIIAGGTENMSRAPYLVQQGRFGYRMGNAPLEDSLLKDALTDAFHGYHMGMTAENICEQWGLTREQLDEFAANSQQKCEAAMNEGRFKEEIVPVEVKTKKGSVIVDTDEGPRKGVTAEGLAKLKPAFKKDGGMVTAGNASGINDGAAAIIVMSEEKAKELGITPMATWIAGELAGVDPSIMGIGPVAATKKVLNKTGMQIGDFDLIEANEAFAAQSVAVGHDLGFDLDKLNVNGGAIALGHPVGCSGCRILVTLLYEMQKRDVKTGLATLCVGGGMGCAAVVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGG5</accession>
    <name>F7KGG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254845.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04944"/>
    <dbReference type="EnsemblBacteria" id="EGN34113">
        <property type="protein sequence ID" value="EGN34113"/>
        <property type="gene ID" value="HMPREF0994_04944"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5400"/>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041527_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="197"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="396" mass="45558" checksum="E4A080693B6AC19E" modified="2011-09-21" version="1">MINRKEYLEDLIQLKDKNIIKVITGIRRCGKSTLFELYQDYLLQSGVSREQIISVNLEDGDYRNIRTAETLYTYVAERLTENTMNYVFLDEAQQAENFQEAVDWLYVKKNVDLYITGSNAYLLSGELATLLSGRYVEIKMLPLSFKEYVSAFPENHNTAQLYMNYLSNSSFPGTLELVRKQDIRAYLEGIYNTILVKDIVTRKKISDPSMLESIIEFMFDNIGNLCSGTKIANAMTSAGRKISVPTVESYLSALTDSYIFYRASRYDVKGKQYLATGAKYYAADIGLRYFLLGTRQADQGHILENIVYLELIRRGYEVYIGKVSAQEVDFIAINSEGEEYYQVSQTVMEEQTLKRELSSLEAVKDHNPKYLLTMDYTPLTSHNGIKQMNVLEWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH08</accession>
    <name>F7KH08_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ORF">HMPREF0994_05144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255045.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05144"/>
    <dbReference type="EnsemblBacteria" id="EGN33177">
        <property type="protein sequence ID" value="EGN33177"/>
        <property type="gene ID" value="HMPREF0994_05144"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5622"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="44" mass="5081" checksum="17AA0278584EB5C0" modified="2011-09-21" version="1">MKMTFQPKNRQRNKVHGFRARMSTPGGRKVLAARRAKGRKRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH40</accession>
    <name>F7KH40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antibiotic transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255075.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05176"/>
    <dbReference type="EnsemblBacteria" id="EGN33209">
        <property type="protein sequence ID" value="EGN33209"/>
        <property type="gene ID" value="HMPREF0994_05176"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5655"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="34104" checksum="5347480E738FDE52" modified="2011-09-21" version="1">MDKKYIIETKNLTKQYGSQKSVADLNIHVQRGRIYGLLGRNGAGKTTTMKMLLGLTKPTSGEVKIWGKALQGNEKKLLPRIGSLIESPGFYPNLTATENLRIFATLRGVPNNHAIKDALDLVGLPYKDKKLFSQYSLGMKQRLAIALAVMHDPELLILDEPINGLDPIGIAEVRSFIRELCDARGKTILISSHILSEIALLADDIGIIDHGALLEEESLAELEQKSSKHIRFTLSDTAQAARILERTFHESHFSIQDDHNLRLHNLDLSVGKIVTAFVENGLEVSEAHTCEESLEDYFKRVTGGEGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH53</accession>
    <name>F7KH53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006776313.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05189"/>
    <dbReference type="EnsemblBacteria" id="EGN33222">
        <property type="protein sequence ID" value="EGN33222"/>
        <property type="gene ID" value="HMPREF0994_05189"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5669"/>
    <dbReference type="eggNOG" id="ENOG502ZV8V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1756349_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="148" mass="17056" checksum="88B099B26C59A66B" modified="2011-09-21" version="1">MKDYNYNENREEQSAREIGKKFAELGFGTVMTDEEYARSEKRIEKSEKRYKFFGSVFSELRTIIYTPLSIAFHAVSYVAKGIGYISSFGLIAGVYYLYQSFCAFKSGVPFGEIGEFTKAVGFIVFPFIAYLVSYVSEKIYTYFEENAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHC9</accession>
    <name>F7KHC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002589059.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05268"/>
    <dbReference type="EnsemblBacteria" id="EGN33301">
        <property type="protein sequence ID" value="EGN33301"/>
        <property type="gene ID" value="HMPREF0994_05268"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5754"/>
    <dbReference type="eggNOG" id="ENOG502ZBQF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123819_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="151" mass="17197" checksum="3A40BD0D788B9DCD" modified="2011-09-21" version="1">MAYVPVPKDLTKVKTKVMFNLTRRQLVCFTAGALVGVPLFLWLREPAGNSMAAMCMMLVMMPFFLLAMYEKHGQPLEKIVGNILKVAVIRPKQRPYQTNNFYAVLKRQEMLDKEVYDIVHRNEKLAAPSAGKTGRKDRASGKDKEKAVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHH0</accession>
    <name>F7KHH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255142.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05299"/>
    <dbReference type="EnsemblBacteria" id="EGN33034">
        <property type="protein sequence ID" value="EGN33034"/>
        <property type="gene ID" value="HMPREF0994_05299"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5785"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_6_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="5">
        <location>
            <begin position="157"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="6">
        <location>
            <begin position="259"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="588" mass="67476" checksum="CB3712B05B34E0D1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHH8</accession>
    <name>F7KHH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05307"/>
    <dbReference type="EnsemblBacteria" id="EGN33042">
        <property type="protein sequence ID" value="EGN33042"/>
        <property type="gene ID" value="HMPREF0994_05307"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5795"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908364_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="360" mass="41040" checksum="08D4AD5EA61EC21C" modified="2011-09-21" version="1">MKKFTMGVLGLGEGRSIISAVQNSELWELGNICDLNEELCKERCQEFGLDGYTTEYQNMLDDESIDVIGIYTPDQLHAAHIKMALEAGKHIICTKPLMVDLDEAGALLEAQKRTGKTVFVGQSSRYFEPARRQRQDFEEGRLGELITVETHYISDSRWFLDREWSRRKGFSWMYNFMIHAVDLAVWYLPEVEEVYGLGTASENTRERGIQAPDTMKFLLKNKDGRFAGVNGVYAAPTLGSAVEQSISCTLRGTKGISRAGYPKLQYYTNFQPVQKTAQLHEYNELHDYFFRFEAETHHAGEYQNYIEQFARDMNEGITPKPDLKEGIRTLAVMEAMEQSLRLGIPVKVSQVLADRNLCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHV5</accession>
    <name>F7KHV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255287.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05444"/>
    <dbReference type="EnsemblBacteria" id="EGN32885">
        <property type="protein sequence ID" value="EGN32885"/>
        <property type="gene ID" value="HMPREF0994_05444"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992906_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="276" mass="30817" checksum="0262C0ABFF4BAF72" modified="2011-09-21" version="1">MNKRKAFNNKKGFTLVEMIVVIVILGILLAIMVPQLIKYIDKAKAVQCRADVSYIMKEYQIEALEKDPGNAEAACALLESIVLEHNGKLKKKGEIFNGGIYSDVCTSKGLYTCTFDSTYKTVTVTCGEHDEGQIEVKKLADVLNNMDFTNIPGCPHPNLNEYFKGPRTSIDSEAISVDGYGDYGSFAKVIEAKLKEQGINTDGRSWRMYKKGDTYNLFLTDSQKITLNMDTQKVACTQYDITNNKVIHGTITVSKDKQGVEYYPILLGESFVPDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIL9</accession>
    <name>F7KIL9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255505.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05698"/>
    <dbReference type="EnsemblBacteria" id="EGN32187">
        <property type="protein sequence ID" value="EGN32187"/>
        <property type="gene ID" value="HMPREF0994_05698"/>
    </dbReference>
    <dbReference type="GeneID" id="29728753"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055093_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="340" mass="40075" checksum="1A536F457E1C9E91" modified="2011-09-21" version="1">MKIVDKSLTDTTMLLKKNYNSVDLAKFLMCLCVAYGHINFLQDIVPFWNDFAIKYAMRVTVPFFFMSTSFFLFRRVKEDKDGYRQIKKYIMKFLRLYIVWTLLYTPAIIVDKVIKYPYGGIKEGIFYAVTDIFRGASYTQLWFLASLCIGTAVTALCLYIHLKPFAIVCFAFAVYALGIWVQSYYGLFFGFVFIALGLFYAKKNIRLKGITVFLGFFLSMLFGYMEIFIFPVNTITANGEMGFFLIPAAFFLFYFIMHIELKDRIIYVKLRELSMMFYYLHMLVNFGYRCMIKILELLWKKDLVNMFVQYIVVVTVSLLLSEAVLRLSHTQKYSWLRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIQ4</accession>
    <name>F7KIQ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002590583.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05741"/>
    <dbReference type="EnsemblBacteria" id="EGN32230">
        <property type="protein sequence ID" value="EGN32230"/>
        <property type="gene ID" value="HMPREF0994_05741"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6279"/>
    <dbReference type="eggNOG" id="ENOG5031AIZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188176_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="86" mass="9702" checksum="2FB63A1523F5A309" modified="2011-09-21" version="1">MNGTNGNEPGYPEKALVPYPVILAATKGDPDAMKIVLQHFSGYIARLSMRKLYDERGNVYFGVDHDIRERLQAKLMMAVLTFKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ36</accession>
    <name>F7KJ36_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255641.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05865"/>
    <dbReference type="EnsemblBacteria" id="EGN31493">
        <property type="protein sequence ID" value="EGN31493"/>
        <property type="gene ID" value="HMPREF0994_05865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6418"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102849_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="167" mass="19451" checksum="D57C21D2FBA1DDEC" modified="2011-09-21" version="1">MWDKIKPEEMTDNVFRLINEDWMLVAAEDEGRVNAMTASWGGLGILWGKRVAFVFVRPQRYTKEFIDKNEKLSLSFFDDSSRKMLNYMGTVSGRDEDKIAASGLHVEMVNSAPVFKESRMALICRKLYEQPMTEESFLDKGLVDQFFEEKDFHIMYVVEIEKILVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJC4</accession>
    <name>F7KJC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05868"/>
    <dbReference type="EnsemblBacteria" id="EGN31496">
        <property type="protein sequence ID" value="EGN31496"/>
        <property type="gene ID" value="HMPREF0994_05868"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6421"/>
    <dbReference type="eggNOG" id="COG4709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631329_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="434" mass="47595" checksum="8217393239944087" modified="2011-09-21" version="1">MNRQEFMKQLEMLLSDISQAEREEALQYYNDYLDDAGIENEEESIGSLGSPAQVAANIKEGLRDGIETGEFTEGGYHMNMEEEAPAAAEAAEESEASGNNSDRIVLQLGDDFSEDIFAKAFDEEKTAENNVSDTMETENREQESSGARADAFQEQGQDTSREQGQETAGRQQNGRYQENQYQNTQYQGNPGQGSQYQGNPGQANQYQGNPGQGTQYQGNPSQGNQYQGNPNRGAGYQENPGGQYQGNPNQGYQQGQPYQGSPYTNNNQGPYRNQYQNTYNQYQGQGPNQYQYQNQYGYSYDTYNRPPKKRRTAGEIILFVLLCIFALPIIVPIGIAVLAVIFSIAVAIIAVVASLVVAGFIVLAVGVVLVIEAFTKLFLFPAGAIYLLGGGLICTGIGLAMTAGMIWVAAKVVPVVCTAFVRACRWPFTRRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJL0</accession>
    <name>F7KJL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NitT/TauT family transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255820.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06044"/>
    <dbReference type="EnsemblBacteria" id="EGN31398">
        <property type="protein sequence ID" value="EGN31398"/>
        <property type="gene ID" value="HMPREF0994_06044"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6616"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062584_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027024">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027386">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363840" evidence="2">
        <location>
            <begin position="26"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="373" mass="39197" checksum="1607545C3DD4F9B6" modified="2011-09-21" version="1">MKKFLSVLAALTLSVSMLAGCGNKANQTEPSAVPESSQAAESVSETVSAAPEASEQESSTAEETETAAMTGEETAVRVMALKGPTAMGMVKLMDTAEAGPVNGNAYEFTIAASADEVTPKLVQGDADIAAVPANLASVLYNNTEGKIQVLAVNTLGVLYIVESGDTVQSAADLKGKTIYASGKGSTPEYALNYILSSNGIDPEKDVTIEWKSEHSECVAALASDEGGIAMLPQPFVTTAQSKNDKIRIALDMTKEWDALQKDAENPSALITGVVVVRSDFAAENPDAVNAFLDSYKESVDYVNGNTEDAAALIEKYDIVPAAVAVKALPYCNITFIEGSEMKEKLSGYLSVLSDQNPKAVGGTLPADDFYYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK03</accession>
    <name>F7KK03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255968.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06192"/>
    <dbReference type="EnsemblBacteria" id="EGN30685">
        <property type="protein sequence ID" value="EGN30685"/>
        <property type="gene ID" value="HMPREF0994_06192"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6780"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="380"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="56153" checksum="87D9E0698944B9EB" modified="2011-09-21" version="1">MYSICIADDEKYVLKSIAQRISSSGMELEVVGMAGNGLEALELYDREQPDIFFVDINMPVVNGLDFIERIRKKAPDVRTRFIIISGYDDFAYMKKAIQLGVINYIKKPILQQEFTDMLRDVCRQLDEEREKEEKKEENIYSWTDFLQLRKWKDIDGTYFLIRGKEIGKEAGNCLGELEAMGGGKEWKVIRFYGAPDILLLVWEGKNCTGREIEAAAGKKCFSRAEQIVYMTGKCRNPEEMISQFEDTLNIRFYHPEYRLMKIKSQSCEKPGIYYEAFEAALECTRENKYSECLSEIIKTLFSDENYCNLVKQVYQSVVLIIANKYTKYDLQLPVKLRQELFPFAAAAFENKRDMLSRLDGYSEEINQRIGEILSRSELVDKVIQYIGLHYKEEINLSDLAGEFFVVPTYLAKKFKEKKNCTVMQYLENVRLKKARELLETSSLSISDISLMVGYNDPNYFARSFKKVYELTPREYRNICGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK62</accession>
    <name>F7KK62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-D-xyloside xylohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06241"/>
    <dbReference type="EnsemblBacteria" id="EGN30510">
        <property type="protein sequence ID" value="EGN30510"/>
        <property type="gene ID" value="HMPREF0994_06241"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6839"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009658_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN30510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="663" mass="75468" checksum="6B268E58C3EF4036" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKI6</accession>
    <name>F7KKI6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsZ</name>
        <name evidence="7" type="synonym">rpsN</name>
        <name evidence="8" type="ORF">HMPREF0994_06365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256127.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06365"/>
    <dbReference type="EnsemblBacteria" id="EGN47973">
        <property type="protein sequence ID" value="EGN47973"/>
        <property type="gene ID" value="HMPREF0994_06365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN47973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="61" mass="7177" checksum="4A0675C7D9883504" modified="2011-09-21" version="1">MAKTAMKIKQQRKPKFSTREYTRCKICGRPHSVLRKYGICRICFRELAYKGQIPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKK1</accession>
    <name>F7KKK1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">HMPREF0994_06380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256142.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06380"/>
    <dbReference type="EnsemblBacteria" id="EGN47988">
        <property type="protein sequence ID" value="EGN47988"/>
        <property type="gene ID" value="HMPREF0994_06380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6982"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN47988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="105" mass="11938" checksum="74AEA7B960F08544" modified="2011-09-21" version="1">MANQVMRITLKAYDHQLVDASAKKIIETVKKNGAQVSGPVPLPTKKEVVTILRAVHKYKDSREQFEQRTHKRLIDIIAPTNKTVDALQRLEMPAGVYIDIKMKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKN4</accession>
    <name>F7KKN4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Poly-gamma-glutamate synthesis protein (Capsule biosynthesis protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48021.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06413"/>
    <dbReference type="EnsemblBacteria" id="EGN48021">
        <property type="protein sequence ID" value="EGN48021"/>
        <property type="gene ID" value="HMPREF0994_06413"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038823_2_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="4">
        <location>
            <begin position="103"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN48021.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="418" mass="45303" checksum="A9F1D387075BFC9C" modified="2013-09-18" version="2">MAVRKKKKKTGRFSIFFLTLIITISLGSAVLLVSWAFLGNEGIALAAVSVEGEVISFFNGETAEAAEDVKEDTGKYADTLADPEAMAAQNIYAVTPSAEGEISLVFAGDILFDDGYAVMAKMKSRGKGIDGSIAPELLEQMRGADIFMVNNEFTYTKRGSPTPGKTFTFRADPAYASYLIDMGADLVSLANNHSYDYGEVSLTDTLDTLQSIGMPYVGAGRNLEEAVKPVSFIAGDVKIAFLSATQIERVDNPDTKGATENSPGVFRCRNVDMLLEEVTKAKAENDFVVVYIHWGTESTSELDWAQKEQAPKIAAAGADLIIGDHPHVLQGITYYGETPVIYSLGNFLFNSKTLDTCLVKVTLDSESGALKNFQFIPALQKDCYTSLLAGSEKDRVIRYMQSLSPEVLIDGNGFVTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKR4</accession>
    <name>F7KKR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256205.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06443"/>
    <dbReference type="EnsemblBacteria" id="EGN47578">
        <property type="protein sequence ID" value="EGN47578"/>
        <property type="gene ID" value="HMPREF0994_06443"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7053"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="125"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="31961" checksum="C33F066B1D41513E" modified="2011-09-21" version="1">MSKDNFVLQIKASYNQFTKAEKKVADYVLDNQEKVLYMSITDLADACEVGDASVYRFCRTMKLQGYQEFKMKLSLSQAASEGFGTEAGRGREDSFGAMAQRIMEQHISAIRETYMLLERETFSKVISMFEAAGRIHFFGIGDSLLTAEEARNKFLRLTNKVSCITDPHMQSMAASLCTQDDLIIIISYSGATKDNIHVAKLAKEAGAKIVCITHFRKSPLTEYCDAVLLCGSNEAPLEGGSMKAKMSQLYLVDMLYQEYYERNFEECKRNNEITSRSVVEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL31</accession>
    <name>F7KL31_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256322.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06560"/>
    <dbReference type="EnsemblBacteria" id="EGN47279">
        <property type="protein sequence ID" value="EGN47279"/>
        <property type="gene ID" value="HMPREF0994_06560"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7182"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="106" mass="11967" checksum="120503603258F704" modified="2011-09-21" version="1">MEYKFTTGDFEKEVLQSDKPVLVDFFADWCGPCKMMAPVVEQLAEEMDGKAKVGKLNIDENMDIAEKYSVMNIPTFLIFKDGQEKARIVGAVSKNELINKLEQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLA1</accession>
    <name>F7KLA1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_06630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256384.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06630"/>
    <dbReference type="EnsemblBacteria" id="EGN46859">
        <property type="protein sequence ID" value="EGN46859"/>
        <property type="gene ID" value="HMPREF0994_06630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7252"/>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590123_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN46859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="463" mass="50870" checksum="1B9A0DDC6237E948" modified="2011-09-21" version="1">MEKKNVWNSYSEEQLKEAEAFAREYMDFLDAGKTERECVDTLVNLIEKEGYVELNALLESGSKIKPGDKIYAVNMNKCLVMYQIGKKPMKEGMNILGAHIDSPRLDVKQNPVYEDSSIAYLDTHYYGGVKKYQWVAIPLSLHGVVVKKDGTTVEINVGDNEDDPVFFISDLLVHLAGEQMEKKAAKVIEGEALDLIVGNIPVKDKDKDAVTAGVLNILKESYGIEEQDFLSAELEIVPAGKAREAGFDRSMILAYGQDDRVCAYTSARAVLEVAGEVTDRTACCILVDKEEIGSVGATGMQSRFFENMTAELMELMGEYSELNLRRCLSNSTMLSSDVSAGYDPSYASCFEKKNSAFMGNGMVFNKFTGVRGKSGSNDANAEYMAHIREIMDSSDVVFQTAELGKVDVGGGGTIAYIMALYGMNVIDCGVAVLNMHAPWEATSKADVYETKRGYVAFLKKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLP7</accession>
    <name>F7KLP7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_06776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256529.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06776"/>
    <dbReference type="EnsemblBacteria" id="EGN46368">
        <property type="protein sequence ID" value="EGN46368"/>
        <property type="gene ID" value="HMPREF0994_06776"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7403"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="293"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="539"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN46368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="664" mass="75459" checksum="A9E3CF011205A578" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLR2</accession>
    <name>F7KLR2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256544.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06791"/>
    <dbReference type="EnsemblBacteria" id="EGN46383">
        <property type="protein sequence ID" value="EGN46383"/>
        <property type="gene ID" value="HMPREF0994_06791"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7421"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="6">
        <location>
            <begin position="184"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="415" mass="45289" checksum="FCAE6E7EE162C16B" modified="2011-09-21" version="1">MSSEIRDINLAGSGEQKIEWVKRNCDLLRMLEEEFSQTKPFAGKKVTLSVHLEAKTAYLCKVLAAGGAEMYVTGSNPLSTQDDVAAALVKAGLEVHAWYGATEEEYNSHIRAVLAAGPNIIIDDGGDLVHMVHTEMQELIPAILGGCEETTTGIIRLEAMNKAGDLKFPMIRVNNAQCKHFFDNRYGTGQSVWDGVMRTTNLIVAGKNVVVAGYGWCGKGVAMRAKGLGAKVIVTEINPVRAIEAVMDGFEVMPMKEAAKTGDFFVTVTGCDKVIDAEDFAVMKEGAILCNAGHFDCEIDMAGLREIAVESREMRKNIMGYKLPTGQWIFVLAEGRLVNLAAGDGHPAEIMDMSFAIQALSAKYLVEHGKEMTEMLIDVPVEIDEDVAARKLRFMGKEIDTLTAEQEAYLNKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS69</accession>
    <name>S2KS69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359694.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06952"/>
    <dbReference type="EnsemblBacteria" id="EPC05284">
        <property type="protein sequence ID" value="EPC05284"/>
        <property type="gene ID" value="HMPREF0994_06952"/>
    </dbReference>
    <dbReference type="GeneID" id="29725737"/>
    <dbReference type="HOGENOM" id="CLU_631328_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="434" mass="48857" checksum="71999AD626C14266" modified="2013-09-18" version="1">MRSWVETFRYLFNVKDDYGRGRLYMLLTLLLLGIAEQFYGGVFFTRFLLAYGIDQTGVGVLTFLPYLGCLISIFSPYILERFQRRKWILFFSGMITNFFSIMGITLLPMIVEDAGQRLMGFIAITVGTTLINNLFSAGGVTWNAAYLPEHVKADYMATSQMLNNLICWGIALAVSIVADQFAGTEHEMPLIICVRCIGWGLTVINSILLLVKKEFPYTHTEKTKLSNVFILPFGNKLYRGTMLVAFVCCIVHYLPNATINVYLLEDLKISYTLINGLNAVYFVFGLLFANMWAGFTKKHGWFVTLAVAVVLQSFTYFVYAFVQADNTWLYIVVRLAQHFVGVPFDLVMVSFIYINLPMEDTTYYVTFAGFIINIATFLAMFIGTVVTKIMGETVLSIFGVNFVSTQVLLLVCAVGKLLVAALSVLWSRKISSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSV3</accession>
    <name>S2KSV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TrkH family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06995"/>
    <dbReference type="EnsemblBacteria" id="EPC05327">
        <property type="protein sequence ID" value="EPC05327"/>
        <property type="gene ID" value="HMPREF0994_06995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026429_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EPC05327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="477" mass="51213" checksum="8B2B162F0D6D0935" modified="2013-09-18" version="1">MEEESDTGRIVKQKGDSDEKINIQEGHNLRGRQKSRLCFFIPFFRKGMNYIKGQPPGRIIAMGFGFVILTGSFLLMLPCSVREGAQVSFIDALFTSASAVCVTGLIAIDTAEHFTVFGRTVVALLIQIGGLGVTSVSVGFILIAGKRVGLKGRRLVREAMNVNTSKGMVRLVKNILLMTLCFECVGAVLSFLVFVRDYPPLEALGISLFHSVAAFNNSGFDILGGLTNLIPYQNNVLLNLTTGGLIIFGGLGFLVILDILGNRSFRKLTLHSKIVITMSLILLAAGTLSLKATENVTWLGAFFQSVSARTAGFSTYPIGSFTDDGLFVLILLMFVGASPGSTGGGIKTTTLFVMIQAARGAAANQYAGAFKRKIPDDVIRKAFIITFLSGMVVCVGTFVMCLLEPEFSFLQLLFEVTSAFGTVGLSTGITPDLGIPGKALIIMIMFIGRLGPLTIASLWAFKTTANARFTEENVTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVQ5</accession>
    <name>S2KVQ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360177.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07224"/>
    <dbReference type="EnsemblBacteria" id="EPC05075">
        <property type="protein sequence ID" value="EPC05075"/>
        <property type="gene ID" value="HMPREF0994_07224"/>
    </dbReference>
    <dbReference type="GeneID" id="29728756"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760287_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="161"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="364" mass="41051" checksum="207CC0396A75D299" modified="2013-09-18" version="1">MKRRKSRAAAAIGLTAVILVVILLFFGFYHKRALSGKDEGRDLLYQLREGTVYRWSEEGITEDKADSWSTYIVVCGDQMEPLKKLCINFTRDEEHLIMSCREDGSFQSMWRLESGEHTITVPENAYALYIAVHNDDMSNLRLKNTWKAESESTYRGKYLSVLGDSISSYEGYIPQGFYPEYGADSGMGVSSMWWYQTALKLGMNICRINGCSGSGVLPAGDGTGGNEERCVSLHTPEHAPDLILILLGANDLFGGCSKEELRLEYQEMIERTQTRYPDAEIVLCSYYRPSQVSFEVDEANEIIKSTGEAYGLKVVELKKSGIEERDPKEVYSDYNPEMGTGMHPNAEGQLLLSNYVCQELTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2C9</accession>
    <name>F7K2C9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249957.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00008"/>
    <dbReference type="EnsemblBacteria" id="EGN48241">
        <property type="protein sequence ID" value="EGN48241"/>
        <property type="gene ID" value="HMPREF0994_00008"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.10"/>
    <dbReference type="eggNOG" id="ENOG5031N9G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153097_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024215">
        <property type="entry name" value="DUF3847"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12958">
        <property type="entry name" value="DUF3847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="104" mass="12240" checksum="E1ECF61815ACC874" modified="2011-09-21" version="1">MNEKLEALNQEIEKTEKKLRRAQHEEKILEHQIKTLTRKERTHRLCTRAAMLESYLPHPEAITDEQVSVFLKLLFHKDSTRQLMEKVFAGNGNFQGEDAGRKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2F6</accession>
    <name>F7K2F6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249984.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00035"/>
    <dbReference type="EnsemblBacteria" id="EGN48268">
        <property type="protein sequence ID" value="EGN48268"/>
        <property type="gene ID" value="HMPREF0994_00035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.38"/>
    <dbReference type="eggNOG" id="COG2105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096369_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="210" mass="23537" checksum="0581C0A12DBFB215" modified="2011-09-21" version="1">MSINHIETEDLRRMEGKGGLILQGCGGELQEWLDGINEMFTEAGILKNGAKFQDIFAFEYNDSPCLLYPFEGVDLEIGKLAMWRLQTHETFGGTWLSDFVPNRLGGFIGEPAPEPEKPDCALIGQDGNIFNLVGIAERTLREHGLTDQAKEMKDRVFASGSYGEALCIIGEYVNITDTEPEQRPSLRQQLKETKTAEPSARLKPEKQQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2G4</accession>
    <name>F7K2G4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00043"/>
    <dbReference type="EnsemblBacteria" id="EGN48276">
        <property type="protein sequence ID" value="EGN48276"/>
        <property type="gene ID" value="HMPREF0994_00043"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.46"/>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031118_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="463" mass="52927" checksum="762A5CBCD14B2256" modified="2011-09-21" version="1">MPLHVGKGRDVSTAIADIIDYVENPRKTDFGKFIYGYECDTRIADAEFLLSKRQYLNLTGRDRGADDVIAYHLRQAFKPGEVTPEEANQIGRELALKLTKGNHAFVVCTHVDKHHVHNHIIINSTALDCTRKFRNFWGSTWAIRRMNDKLCLEHGLSIVENPKPSRDHYGTWLGNTKQPSFQEQLRRAIDAALEERPKDFEDFLKKLEAAGIEVNRERKNLRLRGPGQKNYTRCNTLKGDYTEQAIQERIEGTRTAKPRRTFSQKPVPKAGLLVDIEAAVRAGKGPGYERWAKVFNLKQLSQAVIYLKEHGDMSYEDLLEKAAAATISFNALSAKIKELESQMTANGELQKQIVNYAKTRAVYVEYRKAGYSKKFRAEHEADILLHQAAKKYFDSIGITKLPSVKSLREEYAGLLEQKRKAYAAYKQARSDMKELHNIKANVDYLLDIPASQEQQKDKQKSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2G7</accession>
    <name>F7K2G7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249995.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00046"/>
    <dbReference type="EnsemblBacteria" id="EGN48279">
        <property type="protein sequence ID" value="EGN48279"/>
        <property type="gene ID" value="HMPREF0994_00046"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.49"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN48279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="27392" checksum="A1DB7803ABEE6318" modified="2011-09-21" version="1">MAREILLSKKTEQGLRLDPRTKLLLIFIISIFVMGGTGGEAMGLIRLVLCAVPALLLLTSKQFVKAVSYIAVFSVFYAVQVYVLPHLTGILNFLVLFTTGFFCRILPSVAIAAYAVKTTTVSELISGMERIHMPKEVTIPLTVMFRFFPTVFQESEAISDAMKMRGIKLGGKKSSKILEYKLIPMITCSVKIGEELSASAITRGLGAPVKRTNICQLKFNFADVVLILFCCFVVFWAIASPIISAGGILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Q5</accession>
    <name>F7K2Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250083.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN42751">
        <property type="protein sequence ID" value="EGN42751"/>
        <property type="gene ID" value="HMPREF0994_00134"/>
    </dbReference>
    <dbReference type="GeneID" id="29724011"/>
    <dbReference type="HOGENOM" id="CLU_1123409_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363668" evidence="1">
        <location>
            <begin position="24"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="247" mass="27443" checksum="0ED2E195D1638998" modified="2011-09-21" version="1">MKKKFSIILCIALISGLSITVNAAGKGLVNEKTYYVVTDMNELMWLGAEQLVSRSSIYGTENENKKSMTVIQTVKERSYQNGTVETEVMMHEIAYKDKNGKLLTAYEIAREIGYISGSKPTTPITEYGVTLVNTIYATLRLDPTSALIPAYRCDRVTTTIIVPPSGVLPTTGSTYYKHHHANEEKEQYFTANLSPGQQVFTLYPDNPQFAQSASIPLYYGLHAQSKVSLANGHTMIVQNGISQEEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V4</accession>
    <name>F7K2V4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00183"/>
    <dbReference type="EnsemblBacteria" id="EGN40740">
        <property type="protein sequence ID" value="EGN40740"/>
        <property type="gene ID" value="HMPREF0994_00183"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.195"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="16"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="234" mass="26318" checksum="48FCB3A6CD474DDD" modified="2011-09-21" version="1">MPESGCSGTGGVPIAALLIVEDDKKTNEAICEYLKSAGHETIPAYDGAEAIQIFREKKIDLAVLDIMLPKITGLAVLHEIRRTSLLPALMLTAIEEEDTQVQSFDEQADDYITKPFSMVLLGKRITALLRRSGQGVIPDTMTFGEVTVDFSGYSAWDREGKIELTPKEIDLLLLFVEHKGLVLTRNQILDELWGDDNPIIDRTIDTYVKNLRKKCRFDRIITVKGIGYKYEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V6</accession>
    <name>F7K2V6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250134.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00185"/>
    <dbReference type="EnsemblBacteria" id="EGN40742">
        <property type="protein sequence ID" value="EGN40742"/>
        <property type="gene ID" value="HMPREF0994_00185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.197"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039499_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="474" mass="52030" checksum="691520C4D31FDCC3" modified="2011-09-21" version="1">MGFLKRAFLYVTKKRGKSILLFIIFLVMATFVLTGLSIEKAAQIAQDNLRYALGGEFEIVPDYSESNPYYKRLTDDEGNFSIYTERPVTQEIIDKVMETDGIKSYDGMAQSLVSTNLEVIPGTVPVKDKYRDMVYSRFVTGTENNSFFRSETLKLIEGSHVPVKGGQVAVISRDLAEKNGLGIGDSLSLTREDGERTELKIIGLFEVVKQAQAYINVNSFDKLENQIFTGIQACQDGLPHSLPGFQSVIFEVNDPARLDDIVSQLKENDAIDWRAYKVETDNKTYLAAAAPLEKSQTLITSFLLLIVLVSAVVLSLILTMWAKSRIHETGVLLSIGFGKASIIGQYLAEVLFIAAIAFGLSFFSGSLIAGRIGNSLLQLQYTREQSIQEPDEGENGVQVSRKGDRNPDVVISDNGNGGEPIPNKDFPEPLSVSVGLDSMVKLYLIGFAIITFSVGVSSAAVMRLKPGEILAKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Z0</accession>
    <name>F7K2Z0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37858.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00219"/>
    <dbReference type="EnsemblBacteria" id="EGN37858">
        <property type="protein sequence ID" value="EGN37858"/>
        <property type="gene ID" value="HMPREF0994_00219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049285_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37858.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="369" mass="42131" checksum="0D45800B4BD96B71" modified="2013-09-18" version="2">MTVWIIIIFITILIWNFLPPSPGKMPLFYNNNGSIIPDSLSEKIYININGAEIGLLITGRDKTNPVLLFLGGGPGIPEYLLEYLYPSKLADEFVVCYLEYRGTSISYDSNMNADSLTTECYLSDVAAVTEYLKSRFSKEKIYLMGHSFGTFIGIQAAFEHPESYHAYIAVSQIADQAESERLAYQYMLDQYQQMNNLKMVKEFEKYPIATSDSAYEDYCLSSLRDKAMHDLGVGTTHNMKSVITGIFLPSLRCKVYTPLQRINIWRGKKLMAASPVGFDRMQFNAFVEIPCLEVPIYFFGGIHDYTCCYSLQKKYFSRIKAPLKGFYTFNYSAHSPLWEESDRAIEILVHDVLRGTNFLSDKQTQTVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K383</accession>
    <name>F7K383_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250261.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00312"/>
    <dbReference type="EnsemblBacteria" id="EGN33453">
        <property type="protein sequence ID" value="EGN33453"/>
        <property type="gene ID" value="HMPREF0994_00312"/>
    </dbReference>
    <dbReference type="GeneID" id="29723703"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.336"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356596" evidence="2">
        <location>
            <begin position="29"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="557" mass="62804" checksum="8FF3732BFB5D4E9A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3B8</accession>
    <name>F7K3B8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00351"/>
    <dbReference type="EnsemblBacteria" id="EGN33492">
        <property type="protein sequence ID" value="EGN33492"/>
        <property type="gene ID" value="HMPREF0994_00351"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.380"/>
    <dbReference type="eggNOG" id="ENOG50302XC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035701_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="542" mass="62124" checksum="D838E13CDB4FD282" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3E3</accession>
    <name>F7K3E3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250325.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00376"/>
    <dbReference type="EnsemblBacteria" id="EGN33517">
        <property type="protein sequence ID" value="EGN33517"/>
        <property type="gene ID" value="HMPREF0994_00376"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.407"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="91"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="34988" checksum="6E3DD9EA3DFA4548" modified="2011-09-21" version="1">MVCKILCILLFLIVLALAMRLFSLRRGLLLIRRDLKEINDEGISLRHLTAESPDTHLQELAGEINRYIDASFAKSRMESMREQEILAEITNISHDLRTPLTSISGYLELIGEEELSPEQKENLDVVQRRTAYLNQLIAQLYEYSRLENRELPLKQERLDITHLFKEHILAFYGEFEKAGLKLTLRLTDEPLWVSADENGLLRIFHNLTSNCLKYGQKEASVSLECIAGRAVLTFRNPAEGFTEKDAEQIFHRFYRKDASRHAQGSGLGMSVAKLLAEQMGGRLDARLEEGMLAIRLLLPCADKSADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3N3</accession>
    <name>F7K3N3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250411.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00462"/>
    <dbReference type="EnsemblBacteria" id="EGN48180">
        <property type="protein sequence ID" value="EGN48180"/>
        <property type="gene ID" value="HMPREF0994_00462"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.509"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN48180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="228" mass="24981" checksum="32606C1DD8BED9E9" modified="2011-09-21" version="1">MKKIFLLEDDLTIAKNLILLLRSEGFTVTHAPTRREALAALAGSRFDLALIDISLPDGNGFTVCTEIKESQDIPVIFLTASGDEASVVTGLNMGADDYITKPFRPRELVARIKTALRKSGVSTSAFEICGLHVDTASGVVKKDGSDVFLSALEYRLLLVFINNPGIIITRNRLLDELWDAAGEFVNDNTLTVYIKRLREKIEKDPANPQIILTVRGTGYRLGDGNASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3S1</accession>
    <name>F7K3S1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250449.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00500"/>
    <dbReference type="EnsemblBacteria" id="EGN46818">
        <property type="protein sequence ID" value="EGN46818"/>
        <property type="gene ID" value="HMPREF0994_00500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.549"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN46818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="385" mass="43153" checksum="5FC827EB3ECA9458" modified="2011-09-21" version="1">MEKKCVNEKKCGSCKYLHMTYKEQLKKKEEFVKHELEKCPELKGHFKPIIGMENPWNYRNKVTAVFDRDRKGNPISGVYQEGTHRVIPVEKCLIEDELADKIIGTIRGMLRSFKIKVYDEDTGYGLLRYVLVRRGFATGEVMVVLVTASPIFPSKRNFTNALLKAHPEITTVVQNVNNRTDSLILGDKQQILYGKGYIEDILCGCRFRISPASFYQINPVQTEKLYSKAVELAGLSGKETVIDAYCGIGTIGLIASKHAKNVISVELNPDAVRDAIVNAKVNGIKNVRFYKADAGRFLTQMAEEGAKADVLLMDPPRNGSSEEFLRSAALLGPGKIVYISCNPVSLGRDLGVLKKLGYRAEECWMVDMFPWTAHVETAVLLVRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3V3</accession>
    <name>F7K3V3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250481.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00532"/>
    <dbReference type="EnsemblBacteria" id="EGN45536">
        <property type="protein sequence ID" value="EGN45536"/>
        <property type="gene ID" value="HMPREF0994_00532"/>
    </dbReference>
    <dbReference type="GeneID" id="29723657"/>
    <dbReference type="HOGENOM" id="CLU_1633148_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN45536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="18621" checksum="379FE04B65BF5169" modified="2011-09-21" version="1">MQIQTINKLKELTDNRKQLFTEYLTITQKLTDLKEEDVEQITAGMEQRAALAEQIDDLGMQSRKVCRVDGGEEHLTEILQCRADFSLLSEEEKELFSLCQSVNRILLEIQDQEVLVHRNFEDIRNKLQESIHRNNTGAKFAGYLNHMNYGASKGVLYDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K418</accession>
    <name>F7K418_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flagellar motor switch protein FliN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_00606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250555.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00606"/>
    <dbReference type="EnsemblBacteria" id="EGN44794">
        <property type="protein sequence ID" value="EGN44794"/>
        <property type="gene ID" value="HMPREF0994_00606"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.659"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033893_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="9">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="9">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="FliMN_C" evidence="8">
        <location>
            <begin position="365"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN44794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="442" mass="48703" checksum="B1FBE57F7BEA4B48" modified="2011-09-21" version="1">MGANRFSPVEIDAIGEILNISLGASATAASTMLDARVDITTPVVRVESRDEFSFKNLEPAVGVEITYVDGLTGDNVMLLKRQDVKAIVEMLMGMEIADEDFELNEMNISAICEVMNQMMGASATALSELLGKPVNISTPRSFEITSDEQFKEKYFTEGNHNMVVISFHLKIAGKLESDFLNLMPIRLAKELVLGFFPEGFDGIEGAGEEQTMQEEIPAEKPVYEAQPEAAPDTFGFVMDQTVPDTTSMDTSLMDTPAGQMQASPEEREIPMQEQSAVPPVTGQDTAQQMYMQPQQTAAVQMDSAALSKELLEMQRIQMELMEQMRQMQAERMERKPRQIRVHSSVQPSLHDESAGEGDPDSNLDLIMNVPVEVSVEMGRTKKLVKDILELNKGSLVVLDKLAGEQVDLFVNGQCIAKGDVVVVDDNFGIRITQILSEDIPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4W3</accession>
    <name>F7K4W3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43201.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00892"/>
    <dbReference type="EnsemblBacteria" id="EGN43201">
        <property type="protein sequence ID" value="EGN43201"/>
        <property type="gene ID" value="HMPREF0994_00892"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43201.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="315" mass="35270" checksum="E203A94F5584BFEB" modified="2013-09-18" version="2">MKSKKNSVKAALPKKQSFSSYMKGHYDLYLLLLPAVVYVAVFMYVPMYGVLMAFQDYSPARGILGSTFVGLKHFDKFFSTYMAKQIITNTVVLSAYSLIVSFPFPVMLALMLNYCVSKKFGKLVQTVTYMPYFISVMVLVGMMNIFFSSNYGVVNMVLKALGMEAYTFMSSEASFRHMYVWSGIWQGMGYSSVIYFAALAGIDPTLYEAAELDGASKLQRILYIDLPSIMPTVIIMLIMSAGNLMSVGFEKAYLMQNDRNSGVSEILSTYVYKVGLIDARYSFSAAINLFNSVINFVILITINKISGKLSETSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K518</accession>
    <name>F7K518_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PNP_UDP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250903.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00954"/>
    <dbReference type="EnsemblBacteria" id="EGN43263">
        <property type="protein sequence ID" value="EGN43263"/>
        <property type="gene ID" value="HMPREF0994_00954"/>
    </dbReference>
    <dbReference type="GeneID" id="29725337"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1042"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="28216" checksum="5D04616A99F1C6C5" modified="2011-09-21" version="1">MLTETFDKDTEQMISPEAVYGVREKVCDICIVTFSDVVVEEIRKKFDCTTVAEIGSVNGGRPIYLLEYKGKKIAFYMTMISSAAAGACLEEARCLTGAGSYIMFGSCGALNREITAGKIIVPTQAYRDEGLSYHYAPPADYITMKNAGRVSEWLEEMGLPHVSGRTWTSDAIYRETKANVDKRKAEGCIAVEMECAGMQAVCDFRGLDLYYYLISGDLLDSEEWDMRILGDEEEKKHQLKNFYIALEMALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K528</accession>
    <name>F7K528_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250915.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00966"/>
    <dbReference type="EnsemblBacteria" id="EGN43275">
        <property type="protein sequence ID" value="EGN43275"/>
        <property type="gene ID" value="HMPREF0994_00966"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043516_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="245"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="481" mass="55294" checksum="7BDB700079A7AF5D" modified="2011-09-21" version="1">MENNTDLRKVVYSIMLTQIQFGTYRCGEKLPTIEETSKRLCVSIDTARTAYLKLKDEGYITLSKNVGATVKVNYDSQETEQFIQTFFSARKNAMIDLINSMLPLFGNAQCVGMKNASPEMLRKMEELFTEKNIEAPYAMLRHLNQKYSSLGNNLLMRLAWQIFMFLHDPFFSIKDNLHYFDQSEDYLSIVLVLCRKKEWTALRVKMAESMNKLTSSLTRFYKDRIHMPSPEKEVAFTWSSYKKSQQLCYSIAMELLISINRGLYPAGSLLPSQEELARQKNVSVSTIRRTLELLGSVGAIKSARHVGTRVLPLEQTSANSDFTKPVLRRRLLDMAESIQMLALSCKDVSVLTLSSLNTESIEELCVKLKAYKGLRRGENLSYFILSTVGESAPYQTIRTVYSELMRQFFWGYAFRGMNGKQEQINEMYDPFFDELIESLEKMDFCRFSVSLEELAVLELRRTVSFLLHLGISDAESILIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5A3</accession>
    <name>F7K5A3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01032"/>
    <dbReference type="EnsemblBacteria" id="EGN43005">
        <property type="protein sequence ID" value="EGN43005"/>
        <property type="gene ID" value="HMPREF0994_01032"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1129"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="35788" checksum="C0334E9107B784E9" modified="2011-09-21" version="1">MGVNEGKGTLSKAGKAHKRKELWQQVKRHRVLYLFALPCVIWLLVFCYAPMAGIVLAFKNYRFDLGIFGSEWAGLKHFQKFITSPEFWTTIRNTLVISGLKILICFPAPIILALLLNEVRAERFKRVVQTLSYLPNFVSWVVVVQLMTVLFTPYGGIVNQIRQMMGLETVFIMGEKSAFYPLVIFSDLWKGIGWGSIIYLAAITGVDQELYEAAGIDGAGRLKCTWYITLPGISTTIGIMFIMAIGGILNAGYDQILLLQQPANTQISQILDTYVIQTGIKYGKFEYATAIGVFKSVFSLLLVTTTNHLTKKYAEVGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5A5</accession>
    <name>F7K5A5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fur family transcriptional regulator, ferric uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01034"/>
    <dbReference type="EnsemblBacteria" id="EGN43007">
        <property type="protein sequence ID" value="EGN43007"/>
        <property type="gene ID" value="HMPREF0994_01034"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1131"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124840_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="19308" checksum="22608D3245D3F57B" modified="2011-09-21" version="1">MPDIKNNQGKRKLPDSRSYHRLQMQRDMIVEKLRERGCRITKQRLTLIDIILEDDCSSCKEIFYKASRINSNIGSATVYRMVSVLEEIGAISRKNMLRVACSEDCSMEDVCTVVLDDNTTYHLSAREWNQVVQTGLRERGYLGKRKVAAITVRPCECGQEDCERPVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5C7</accession>
    <name>F7K5C7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dak1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251005.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01056"/>
    <dbReference type="EnsemblBacteria" id="EGN43029">
        <property type="protein sequence ID" value="EGN43029"/>
        <property type="gene ID" value="HMPREF0994_01056"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1156"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183577_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dak1_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="83" mass="9722" checksum="52D4205BB5873708" modified="2011-09-21" version="1">MLEFRYDTQLLIEGEDLDEDIISEYFTDNFKGDCLLAVGDEELIKIHFHTNEPWKVLEYCSTLGEIYDIVVEDMDRQSRGLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5E8</accession>
    <name>F7K5E8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251026.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01077"/>
    <dbReference type="EnsemblBacteria" id="EGN43050">
        <property type="protein sequence ID" value="EGN43050"/>
        <property type="gene ID" value="HMPREF0994_01077"/>
    </dbReference>
    <dbReference type="GeneID" id="29723626"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1182"/>
    <dbReference type="eggNOG" id="COG4289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028269_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="PTHR35339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="571" mass="65789" checksum="E00EE318F9C43B9A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5N1</accession>
    <name>F7K5N1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-D-xyloside xylohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251116.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01167"/>
    <dbReference type="EnsemblBacteria" id="EGN42929">
        <property type="protein sequence ID" value="EGN42929"/>
        <property type="gene ID" value="HMPREF0994_01167"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1277"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="665" mass="76484" checksum="80ACD1A333C4CE22" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5T2</accession>
    <name>F7K5T2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251160.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01211"/>
    <dbReference type="EnsemblBacteria" id="EGN42537">
        <property type="protein sequence ID" value="EGN42537"/>
        <property type="gene ID" value="HMPREF0994_01211"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1324"/>
    <dbReference type="eggNOG" id="ENOG502Z9EJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068216_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="35630" checksum="6A18F9632093981A" modified="2011-09-21" version="1">MEAKHSMEAKNFMEEKPSIEKTQSMEEKELHVVKKHKDTVFRMLYNDREKLLELYNALNGTVYEDTGDLEICTLENAIYMGFKNDVSFLFDSEMCLYEHQSSFNPNMPLRDLFYISRQLQKYVVGKTLYSSKLVQIPVPRFVVFYNGTQEQPERRLLRLSDAFEKKVSSPELEVTVTMLNINLGKNRELMEKCKTLREYCMFVECIRKYAAQMDIEEAVERAVTECIRNDILADFLSAQRAEVIAMSIFEYNEEEEMKKIRADEFSVGRETGKAEGKEEGKAEGKAEFVLYNVPIDVDTLRRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Q3</accession>
    <name>F7K6Q3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251512.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01563"/>
    <dbReference type="EnsemblBacteria" id="EGN42037">
        <property type="protein sequence ID" value="EGN42037"/>
        <property type="gene ID" value="HMPREF0994_01563"/>
    </dbReference>
    <dbReference type="GeneID" id="29726686"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1707"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020575_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="770" mass="88654" checksum="3AA20A318EE5BBE3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6W8</accession>
    <name>F7K6W8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretion system protein VirD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251551.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01635"/>
    <dbReference type="EnsemblBacteria" id="EGN42109">
        <property type="protein sequence ID" value="EGN42109"/>
        <property type="gene ID" value="HMPREF0994_01635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1786"/>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015347_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="601" mass="68246" checksum="BC4D64F4427B7697" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K714</accession>
    <name>F7K714_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251370.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01421"/>
    <dbReference type="EnsemblBacteria" id="EGN41895">
        <property type="protein sequence ID" value="EGN41895"/>
        <property type="gene ID" value="HMPREF0994_01421"/>
    </dbReference>
    <dbReference type="GeneID" id="29725562"/>
    <dbReference type="eggNOG" id="ENOG503241G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114020_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="203" mass="23085" checksum="BBE37E5DB91E56BA" modified="2011-09-21" version="1">MDNTKYLNGKGRRNYLVCMVIMYAMILFYVMKIVIGVVNSVYVVRMPQEEVNVEFNGYEYRADLPFAGHMKLGKEYYPGYVQPVSGKSLILAVSVMGTLAMDMPVLLLLLYGRRALRRIERERSPFLPETAKDIRRIGQILLLIGFLQKGIFQVGVAEIGFHTYYVDNPFFNGSWICVGFLVLLIGNVFETGCELQAEADQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K733</accession>
    <name>F7K733_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251575.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01662"/>
    <dbReference type="EnsemblBacteria" id="EGN41779">
        <property type="protein sequence ID" value="EGN41779"/>
        <property type="gene ID" value="HMPREF0994_01662"/>
    </dbReference>
    <dbReference type="GeneID" id="29724435"/>
    <dbReference type="HOGENOM" id="CLU_2880130_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="63" mass="6980" checksum="8A1FBD0A8A2C37C0" modified="2011-09-21" version="1">MKEYLKPEVIVLDKKNMPAVFLSGDGICFLGYKACSNNYNGTGVCDKGYVGCGFCYPIEKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7K8</accession>
    <name>F7K7K8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251750.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01837"/>
    <dbReference type="EnsemblBacteria" id="EGN41650">
        <property type="protein sequence ID" value="EGN41650"/>
        <property type="gene ID" value="HMPREF0994_01837"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2012"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="393" mass="43750" checksum="A1BE8F77083631A0" modified="2011-09-21" version="1">MSKLTEEWSDILKEAVHRQEVGGVSLLFLKDGKEICWLGEGYADRENKITIARNTISRLYSMTKPVTAAAAMLLAESGELELDTPVGEYLPGFKNSRVWCGDHSEPAYRPILISDLLTMTSGLTYGDDDTVTELATRKLLAEAEERLKGDNPMTTLEFAERAGEIPLLFQPGTSWKYGISADILGAVIEKAAHKTFGEFLEEKIFAPLGMKDTGFFVPEEKQRRLAKAYERMEDNCLVPYEGSFLGIRNRMARPAAYESGGAGLVSTIEDYALFAGMLLEKGSGNGTRILKPESVEQMMTVGLTQPQQAAFERWFGQKGFDYGWLMRVLKEPSMAASPGLRGEYCWDGWLGCCFFNYPREKMTLLIMQQQKNGGDVVGKVKRALVRHMAGQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7R6</accession>
    <name>F7K7R6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251874.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01961"/>
    <dbReference type="EnsemblBacteria" id="EGN41366">
        <property type="protein sequence ID" value="EGN41366"/>
        <property type="gene ID" value="HMPREF0994_01961"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2154"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033229_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356462" evidence="1">
        <location>
            <begin position="30"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="591" mass="65881" checksum="A5111D6DDA3F74DF" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7S3</accession>
    <name>F7K7S3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIGR00659 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251881.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01968"/>
    <dbReference type="EnsemblBacteria" id="EGN41373">
        <property type="protein sequence ID" value="EGN41373"/>
        <property type="gene ID" value="HMPREF0994_01968"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2163"/>
    <dbReference type="eggNOG" id="COG1346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082099_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="23600" checksum="1E04A97B8CE166E6" modified="2011-09-21" version="1">MAELMSSPFFGVALSILAFSIGVWLQKKTGLVVCNPLIIAIVLVIGVLLLFRIPYEAYNEGGSIINMFLAPATSCLAVSIYTRAELLKKNWLPILVGCTVGALTSMGSVYLLCRLFGLDEAMTNSLIPKSVTTPIAVGISGSHGGMVPVTVVAVIITGIMGSIMAPWLIRIFRVSDSMTAGLAIGACSHAIGTSKALELGETEGAMSGLAIGVCGILTVIFSLFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K838</accession>
    <name>F7K838_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251998.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02085"/>
    <dbReference type="EnsemblBacteria" id="EGN41490">
        <property type="protein sequence ID" value="EGN41490"/>
        <property type="gene ID" value="HMPREF0994_02085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2289"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="318" mass="35379" checksum="575D4DC5926E83EF" modified="2011-09-21" version="1">MKKKVLGISFGRKMGNTDVMIKAALMECEKAGHEVQFIRADDLDIKACTGCISCVVGMTTGRGKGGCPLKDDMHIIDEALMECDAVIVGSPTYVLSPTGRFKTVCDRIGPSHDITFRKATFDEGIKAGKPVDQLPDERSFKKRIGALLSVGGAMTENWLSFMLPTMYEFTMSMGIDVIDMHQYFGAMAYEHVLGNDSEMERARSIGRNIASALDAETEEERIKWRGEEEGICPVCHCSMLTVSKDHTSIECPVCGIYGDLSIENGKIRAIFSKEEQERSRLRWDGKLEHSTEIKTKAVGPGQIPNLKELKEEYQNYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7K899</accession>
    <name>F7K899_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251785.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41277">
        <property type="protein sequence ID" value="EGN41277"/>
        <property type="gene ID" value="HMPREF0994_01872"/>
    </dbReference>
    <dbReference type="GeneID" id="29727413"/>
    <dbReference type="HOGENOM" id="CLU_2585212_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="80" mass="9294" checksum="6601E2DE4D77F673" modified="2011-09-21" version="1">MRLDNKLKIAAFDTAMKSLLKNKNKYPDRTARNILESGAAVFHRSMNEDEKKNAFLHIKEKLPERDEDILAFIRDLFGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8D9</accession>
    <name>F7K8D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252031.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02118"/>
    <dbReference type="EnsemblBacteria" id="EGN41025">
        <property type="protein sequence ID" value="EGN41025"/>
        <property type="gene ID" value="HMPREF0994_02118"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2320"/>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745537_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024559">
        <property type="entry name" value="DUF3846"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025923">
        <property type="entry name" value="YodL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12957">
        <property type="entry name" value="DUF3846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14191">
        <property type="entry name" value="YodL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="370" mass="41767" checksum="0E4D970A35D96B14" modified="2011-09-21" version="1">MKVLMVEPGKVPYAAEIGEGLEPLQAAVGGDIQAVYPYDDPVALICNEEGKYMGLPLNRALHDDEGNIYDIVAGNFFLCGLGEEDFTDLPADLMEKYRQQFEHPEQFVRIAGKILAVKQPVPSPEEQEAQRAQMAAQEAQREEMRLDESTDLAFDLDVFLRQYSDAYADMHPVFHEEKERMADELLSGQTGKIRMRMATVIQEEHLNGEAGPLLDRIAAYEKEYGISAYSIYQLDLSDSTDDLRFMSLDWLEKKGLPVDRDNYQMVYAAELSPGETLEDIYTRFNIDHPEDFKGHSLSVSDVVVLHEKGSDTAYYVDSIGFKEVPDFLGGARQPEAKRDVSLRELLDDAKKQAAKAEPKTPEKKKEPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8M0</accession>
    <name>F7K8M0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="13" type="ORF">HMPREF0994_02208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252109.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02208"/>
    <dbReference type="EnsemblBacteria" id="EGN41115">
        <property type="protein sequence ID" value="EGN41115"/>
        <property type="gene ID" value="HMPREF0994_02208"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2412"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="4"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN41115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="879" mass="96710" checksum="9F5C221D1C3271AE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Z5</accession>
    <name>F7K8Z5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail tape measure protein, TP901 family, core region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252189.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02288"/>
    <dbReference type="EnsemblBacteria" id="EGN41195">
        <property type="protein sequence ID" value="EGN41195"/>
        <property type="gene ID" value="HMPREF0994_02288"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2496"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038247_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10145">
        <property type="entry name" value="PhageMin_Tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMin_Tail" evidence="1">
        <location>
            <begin position="206"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="534" mass="58152" checksum="09E0FB2A402485C3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9V9</accession>
    <name>F7K9V9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40625.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359738.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02642"/>
    <dbReference type="EnsemblBacteria" id="EGN40625">
        <property type="protein sequence ID" value="EGN40625"/>
        <property type="gene ID" value="HMPREF0994_02642"/>
    </dbReference>
    <dbReference type="GeneID" id="29725633"/>
    <dbReference type="eggNOG" id="ENOG50325XY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697896_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40625.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="395" mass="45868" checksum="F01E9A53DFC8C3E7" modified="2013-09-18" version="2">MKLRVEPYQWIIKCITLYSLSTIIYGIVNDYLPLNTILGIILIILFGILYLKNLKKRDIYFFICVLFLFVFDNLVAIDKAASISDSVYWVFTLLAIWKVCDEETYKCLYMAIVKQSDFIKIIFTINNFILVGGLFLGNCYSKSWGSTYYVGFAYSNHVLASGACITLVMALYIFNDIKSIFLRVLILLPATIAILQSGARTYIVSIAVIWLIYFLYCFQKVNIKLFFIPFATIVISYIFINSGMMVKFINPNTYVQQTGIETFSSGRTVFWLIDLQAYWNLGFINKLFGNGFDFPYFVNRTLYKSSMNVWAHNDFINTLMTSGVLGIGLYLTIIRKIWKSLRNYTPFILSSLVWIYVVFVMFINGFFVYQHYLFSFILLFIWSVNNTKNKSLCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Y6</accession>
    <name>F7K9Y6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252570.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02669"/>
    <dbReference type="EnsemblBacteria" id="EGN40652">
        <property type="protein sequence ID" value="EGN40652"/>
        <property type="gene ID" value="HMPREF0994_02669"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2922"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="189" mass="20474" checksum="AC4CE758D9619193" modified="2011-09-21" version="1">MEKKSKVLRKLFFSTLYLSTFTFGGGYVIVTLMKNKFVDELHWIDEEEMLDLVAIAQSSPGAIAVNGAIVVGYKLAGIPGVLCSILGAILPPMIILSLISLCYDAFRTNLIVGSMLKGMQSGVAAVIASVVYDMGSKVVKEKDWVNIVIMGISFIASYFFKVNVVLIIVVVACIGAVRTLMKERKGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA37</accession>
    <name>F7KA37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252621.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02720"/>
    <dbReference type="EnsemblBacteria" id="EGN40703">
        <property type="protein sequence ID" value="EGN40703"/>
        <property type="gene ID" value="HMPREF0994_02720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2976"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="109" mass="12235" checksum="A1AD8E54F58E350E" modified="2011-09-21" version="1">MNYQIKFIPEALNDMKRLDHSVQPQVVKGIQKVSQNPVSINQGGYGKPLGNKDGTNLAGLYKIKFRGIGIRVVYSVEEHDGVMNIIVVSVRADNQVYQEAAKRRTKHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAL8</accession>
    <name>F7KAL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40453.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359722.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02844"/>
    <dbReference type="EnsemblBacteria" id="EGN40453">
        <property type="protein sequence ID" value="EGN40453"/>
        <property type="gene ID" value="HMPREF0994_02844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134256_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025868">
        <property type="entry name" value="Zn_ribbon_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12674">
        <property type="entry name" value="Zn_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40453.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="162" mass="18513" checksum="53B4448DCF69B9B2" modified="2013-09-18" version="2">METMEAILELRKKLNISQDEFARRLSVTRQAVSRWENGDTIPNIDTLKLIAETFEVSVDYLLGHTVGQCQSCGLVLEKDSDKGTECDGSKSEEYCSFCYQHGKFTQDITMEEMIELNLRDLDEWNKSVGLQLTEQEARSALMEFLPTLKRWKDTSGTAIAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB32</accession>
    <name>F7KB32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252962.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03061"/>
    <dbReference type="EnsemblBacteria" id="EGN40238">
        <property type="protein sequence ID" value="EGN40238"/>
        <property type="gene ID" value="HMPREF0994_03061"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3345"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="899" mass="100953" checksum="56567D8E5A26ADAD" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB44</accession>
    <name>F7KB44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antibiotic transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252976.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03075"/>
    <dbReference type="EnsemblBacteria" id="EGN40252">
        <property type="protein sequence ID" value="EGN40252"/>
        <property type="gene ID" value="HMPREF0994_03075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3360"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="271" mass="29828" checksum="1E162A9FE9CDF464" modified="2011-09-21" version="1">MSYAIEIDGLKKSYGNHMVLKGLSFQVARGEIFALLGVNGAGKTTALECMEGLRKFEGGSIAVNGRMGIQLQSSSLPEQIRAMEAVRLFAKWNKTKTDGTMLEALGIKELGKKKYADMSTGQKRRLHLALALVSDPDIVFLDEPTAGLDVEGRISLHEQIRRLKTQGKTIILASHDMAEVESLCDRIAILSSGNVSFLGTVAGLTEKISRRYRIHIKTSKGEECLETENIGAALLETLEEFRKKGTEVMDIKIDRGTLEQHFMEIAKGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBG9</accession>
    <name>F7KBG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40033.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360253.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03203"/>
    <dbReference type="EnsemblBacteria" id="EGN40033">
        <property type="protein sequence ID" value="EGN40033"/>
        <property type="gene ID" value="HMPREF0994_03203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_8_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="118"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="3">
        <location>
            <begin position="498"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40033.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="758" mass="84115" checksum="735E8AB0E7BB51D4" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBK6</accession>
    <name>F7KBK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, family IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03242"/>
    <dbReference type="EnsemblBacteria" id="EGN40072">
        <property type="protein sequence ID" value="EGN40072"/>
        <property type="gene ID" value="HMPREF0994_03242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="27599" checksum="ACB57D3E1233B8D6" modified="2011-09-21" version="1">MTDYTYIIFDVDGTLINFEKSERRAFSRTMESCGIFDDDELHRKYTDICDSVWEEYDLDNTKDPYIRKNYHQLYRSYAVRRFAELKKELNLEKTPEELSRIYTRYYKEERIPEPKAEEVCGRLSQYYTLVLATNGLEEIQVPRAAIFGDCISHIFVSESVGAVKPSAEFFDCICNTLSVASPSECLMVGDSLVNDMEGAAAAGMKTCWYHPGKGSAVCGVNPDYEITALEELLRILQLCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBK7</accession>
    <name>F7KBK7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Uridine phosphorylase</fullName>
            <ecNumber evidence="5 10">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_03243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5 10"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253144.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03243"/>
    <dbReference type="EnsemblBacteria" id="EGN40073">
        <property type="protein sequence ID" value="EGN40073"/>
        <property type="gene ID" value="HMPREF0994_03243"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3543"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN40073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="28460" checksum="6A2ECADCC7BBF547" modified="2011-09-21" version="1">MKYTENGIQYHLQIKSGDVGRYVILPGDPKRSEKIARYFESPCLVADSREFVTYTGLLDGERVSVTSTGIGGPSASIAMEELVKAGADTFVRVGTCGGMDIDVKSGDLVIATGAIRNEGTSREYAPIEFPAVADIDVVNALIAAAKESGHDWHKGIVQCKDSFYGQHEPEIMPVSYELENKWQAWLRLGCKASEMESAALFVVADYLRVRCGSVFLVVANQEREKAGLTNPVEHDTDAAIRTGKEALRKLIADDKKSGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBW6</accession>
    <name>F7KBW6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-exporting P-type ATPase</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Copper-exporting P-type ATPase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cu(+)-exporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HMPREF0994_03363</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03363"/>
    <dbReference type="EnsemblBacteria" id="EGN40193">
        <property type="protein sequence ID" value="EGN40193"/>
        <property type="gene ID" value="HMPREF0994_03363"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3675"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="832"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="794"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="795"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGN40193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="901" mass="96702" checksum="70027953F9DDFB1E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBX9</accession>
    <name>F7KBX9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6273 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40128">
        <property type="protein sequence ID" value="EGN40128"/>
        <property type="gene ID" value="HMPREF0994_03298"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3606"/>
    <dbReference type="eggNOG" id="ENOG502ZAP4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2167693_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046240">
        <property type="entry name" value="DUF6273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19789">
        <property type="entry name" value="DUF6273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6273" evidence="1">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="110" mass="12607" checksum="8CD68FD357F015A2" modified="2011-09-21" version="1">MLSMEEAVCKYFGDSRSKLYNPGKNQRYWFERKDENNGKRTARLEGEKGDIWWWWLCSPGRVNVKAVYIHGDGNIGIQGNNILKGNLSDGRCTGGIRPALWLKLDADKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC99</accession>
    <name>F7KC99_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03478"/>
    <dbReference type="EnsemblBacteria" id="EGN39551">
        <property type="protein sequence ID" value="EGN39551"/>
        <property type="gene ID" value="HMPREF0994_03478"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN39551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="216" mass="25320" checksum="9B799AB21724F926" modified="2011-09-21" version="1">MKLLIVEDEEYIADFMMIGLEKAGYECEIAYDGKAAADVLEEKRYDLILLDIMLPEVNGFELMEYIREYHTPVIFITARSRLEDKVKGLGLGADDYITKPFALAELIARVECVLRRYHKGQEKLLFRDLEIDAVSRVVRRNGENIELTMKELDLLLLFLRNRNITLFRDRIYEEVWEGEYDGESRTVDLHVQRLKKKLGLHTSIISVRKIGYRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCD9</accession>
    <name>F7KCD9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biotin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253419.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03518"/>
    <dbReference type="EnsemblBacteria" id="EGN39427">
        <property type="protein sequence ID" value="EGN39427"/>
        <property type="gene ID" value="HMPREF0994_03518"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3844"/>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052149_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="49"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="324" mass="36063" checksum="5D2893946FFF9755" modified="2011-09-21" version="1">MELTSILAKAEKGEQLSREDAVALLRTDNTSSSFYQLIAAANERSRRVFGNKGYIFAQIGLNAYPCSGNCSFCSLAEKHFVVGEHYEKSCEEVVAQVKEMETDRIEALFLMTTADFSQQKFLEIGRAVRGVLDKKVHLVANIGDFDEAMAVQLKKAGFDGAYHIVRLREGTDTQIPREKRIATLDAITKAGLDLYYCVEPIGPEHTYEELADEMLRAREYKVNMMAVMGRVGVPGTRFADSGEITELELTKIAAVAGLVTAPGKSMNVHEPKKMPLLAGVNQLYAEIGINPRDTSEKTEDNRGKGIRETVKLLEEAEYRVEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCH2</accession>
    <name>F7KCH2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253452.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03551"/>
    <dbReference type="EnsemblBacteria" id="EGN39460">
        <property type="protein sequence ID" value="EGN39460"/>
        <property type="gene ID" value="HMPREF0994_03551"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019175_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="657"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN39460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="762" mass="87996" checksum="4E0F57835916A0B7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCY7</accession>
    <name>F7KCY7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253617.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03716"/>
    <dbReference type="EnsemblBacteria" id="EGN38880">
        <property type="protein sequence ID" value="EGN38880"/>
        <property type="gene ID" value="HMPREF0994_03716"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4056"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096795_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="149" mass="17321" checksum="D5DF2FE589EE8E9D" modified="2011-09-21" version="1">MIIKKAAEDDLQEILDLQYLAYQSEARLFNDPDIPPLKQTLPEVYSEYEKGIILKALNEDCKIVGSVRAVCNDDTAYIGKLIVHPDWQRKGIGTRLLLEIEQLCQKERYELFTSTRSTGNIKLYERLGYVIFKETAVSNELRFVYLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD44</accession>
    <name>F7KD44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03773"/>
    <dbReference type="EnsemblBacteria" id="EGN38744">
        <property type="protein sequence ID" value="EGN38744"/>
        <property type="gene ID" value="HMPREF0994_03773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1642061_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="146" mass="17267" checksum="6F4731E608A7B48A" modified="2011-09-21" version="1">MYDILRDAYSYDSRNKIIWDENWQESDNFFYDNPDIADKYGLVTCIEDFPIGFVTWDPRHRPEYVEIGHNGIREKFKGKGYGHMQLAEAVRRIKEYDGLQRIIVCTNSNLVAPKNYESVGFKLYNRKENNTESAYTGAYLYYSMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD91</accession>
    <name>F7KD91_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03820"/>
    <dbReference type="EnsemblBacteria" id="EGN38585">
        <property type="protein sequence ID" value="EGN38585"/>
        <property type="gene ID" value="HMPREF0994_03820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4159"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1946022_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ_Zn_bind" evidence="1">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="129" mass="14875" checksum="083D77B28DAEC529" modified="2011-09-21" version="1">MTQSGRAGRDGEPAECILLYGGQDVVTNQFFIDNNQDNQEMDPLTRDLVTERDRDRLRKMTFYCFTNECLRDYILRYFGEYGSNYCGNCANCLSQFEEVDVTEVARALIGCVLACRQRYGTNVTQFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDG5</accession>
    <name>F7KDG5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-AF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03902"/>
    <dbReference type="EnsemblBacteria" id="EGN38667">
        <property type="protein sequence ID" value="EGN38667"/>
        <property type="gene ID" value="HMPREF0994_03902"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4246"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708852_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN38667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="320" mass="36691" checksum="465F4D6E5605D3B6" modified="2011-09-21" version="1">MLGLERNAKAVGLACYAPMLANVDYVNWKPDMLWFDNHRIYGSPDYYVQKLFMNHQGSRRLEIYTEGLEAPGIKEEPICGGIRLQGYHSEVIFRDVVLENSKTGEKVSFGDYHLKKEEASVWLADTEWKDYIISCRAEELDGFQIFFGWQDEDNNNSWTVGGWQNYDLLLSRRIRGCCSDLTQSLIRVSKGQEYLLKLQVSGRTVRVWVDGRLCAGTEDKPVMTEPLYYGASRDEADQTVILKVVNLQEQGVSAHIIMKGMCGSRLQGTVYTMQADLAAENDFAEPERVAPQEAVFYKENDSFMYEFPKFSLTVFRLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDL0</accession>
    <name>F7KDL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253856.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03955"/>
    <dbReference type="EnsemblBacteria" id="EGN38720">
        <property type="protein sequence ID" value="EGN38720"/>
        <property type="gene ID" value="HMPREF0994_03955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4306"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="314" mass="34708" checksum="49966116594CE782" modified="2011-09-21" version="1">MAETIKKKKKNEPDGFDRFNRVSNTANVLLNVMFVLMALVCIIPVLLVIAISLSAEASITEYGYHLIPKIVSFEGYEYLAKQSTLIIRALGVSLFVTIVGTVLGILLTTLMGYVLSRPGYKLNGFLTMVVFIPMVFNGGLVSTYFITSQFLNLKDSVWALILPLAVSSFNVVICRTFFKTTVPEELIESAKMDGARQFTIFFKIVLPISLPVLATIGLFLCFAYWNDWYQSMLYIDDQRLYSLQALLNAIMTNVNMLAQNAAAMGASMADTVANMPKEAARMAIVVVIVLPIACAYPFFQKYFISGLTVGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDX8</accession>
    <name>F7KDX8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04057"/>
    <dbReference type="EnsemblBacteria" id="EGN37582">
        <property type="protein sequence ID" value="EGN37582"/>
        <property type="gene ID" value="HMPREF0994_04057"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4425"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN37582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="32513" checksum="B5B48BA4FC4BBE06" modified="2011-09-21" version="1">MKIFRKAGKAAGQVFRFILLLGPVFLMCAPIFLLLSGSVMSRQELSQYLAPLFGNAEGYIGWRLFPQYPTGEHYWKLLLYTPQFYTVFWNSLKLVAAILGGQLLIGVPAAWAFAVYRFRGRKFLFTIYIVLMLMPFQVTMLSQYLVLSRVGVMNTHWAVILPAVFSTFPVFLIYRGFCGIPRGLLEAGRIDGAGEWYLFWRIGLPLSSGGILSAMVLGFLEYWNLIEQPLAFLKDKALWPLSLYLPEIGQDKAGFAFAASVVTLVPSVFVFLLGRDYLEKGIVASGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE98</accession>
    <name>F7KE98_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">HMPREF0994_04177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04177"/>
    <dbReference type="EnsemblBacteria" id="EGN36457">
        <property type="protein sequence ID" value="EGN36457"/>
        <property type="gene ID" value="HMPREF0994_04177"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4557"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN36457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="31715" checksum="00C8FB7222496856" modified="2011-09-21" version="1">MIKIGSHVKMGGKDMLLGSAKEAVSYGANTFMVYTGAPQNTKRKAISELNIDTAWEYMKQNGIEDFVIHAPYIINLGNSVNPETYSLAVDFLALELERTIAMGSRVLILHPGAHVGAGAETGLRQIIQGLNAVLTADTPCYIALETMAGKGSEIGRSFEELAAIYDGVKYNDKLRICFDTCHVNDAGYDIVNDFEGVMEQFDKRLGKDQIAVFHINDSKNSMGAGKDRHANIGEGTIGFDTLRHIVHHPDFPGIPRILETPYRPDPENPDKTLPPYKEEIALLLNTAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEL8</accession>
    <name>F7KEL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254198.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04297"/>
    <dbReference type="EnsemblBacteria" id="EGN36109">
        <property type="protein sequence ID" value="EGN36109"/>
        <property type="gene ID" value="HMPREF0994_04297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="422"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN36109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="526" mass="61699" checksum="114C7541D071FC78" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEQ3</accession>
    <name>F7KEQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254233.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04332"/>
    <dbReference type="EnsemblBacteria" id="EGN35642">
        <property type="protein sequence ID" value="EGN35642"/>
        <property type="gene ID" value="HMPREF0994_04332"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4730"/>
    <dbReference type="eggNOG" id="COG3550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042516_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="412" mass="46101" checksum="F241649ECBD31753" modified="2011-09-21" version="1">MVETIQTYILMHKEIPVAEIRLDSATASVSAVIELFDTSHVPVGIPVKKGKIDRAALNAWWQGRAIPASRSGLRHALEELHISSPQALLVKCLGLSLSDQYWICPADRQVSWHEVNFFENSFSEDVGNILFGHPSGGGEVSLMSPDNTSDGWLKKKWTIMDGKRFLLKGGSGATQQEPYNEVLASRIMERLHIPHIPYTLAVPEDYPYSVCEDFIDPDTELVTAWHIYQTQPKPNHVSVYQHYLNCCEALGIPGVKDSLDRMLVLDYLIVNEDRHLNNFGAVRNANTLEWTSCAPIYDSGTSLWFDKPWTMISAGAKAASKPFKTTHDEQIKLVSSFDWLDIDALAGIDEELRELVKGSLFIDTTRADALCAALRGRVERLAQVVVERRNLYPIDDRAADVTEDVAYSGEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEY0</accession>
    <name>F7KEY0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254317.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04416"/>
    <dbReference type="EnsemblBacteria" id="EGN35726">
        <property type="protein sequence ID" value="EGN35726"/>
        <property type="gene ID" value="HMPREF0994_04416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="34056" checksum="5AFE0A85B83A928F" modified="2011-09-21" version="1">MKKQNKNKIKEGNRAVTAVLYILAAIAAFITLYPMYYVLILSLSEPAYAATMRVYLVPKGFNLSAFQVLVTDMKMWRAYANTVLYVVPTTILMIATSTVVAFGLNYKKLMGRKFLTMFLLIPMYFAGGTIPSFLLIVKLGLYDSPFSQVIPACFSIWNIILVKAYFRSIPESLTEAARIDGASLLQVLLKVFVPLGKPIFAVLAVYTIVGVWNSWFSAMLYLPHTEWQPLQMYLRRILVESKQTLTQVMDAATAKELAMRQLSNAQLKYAMIIFTTLPVLCTYPFFQKYFVKGMVLGSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF14</accession>
    <name>F7KF14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254356.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04455"/>
    <dbReference type="EnsemblBacteria" id="EGN35765">
        <property type="protein sequence ID" value="EGN35765"/>
        <property type="gene ID" value="HMPREF0994_04455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4866"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="34893" checksum="E57B2178FC89BED4" modified="2011-09-21" version="1">MASTKKKGKSKYTIAVFKRELPLHLMLLPGLILVAVFNYTPIAGLIIAFQKFIPSKGMFGDQQWVGLGNFTYVFSLPGFDQALKNTIVIAFWKIVLGLIVPIVFALMLNEVNRNGFKRTVQTIVYLPYFLSWVVLGGIFLDMLSPSSGIMNQIITALGGKSIFFLGDNHYFKPTLIVTDIWKNFGYGAIVYLAAILGIDTDLYEAAQIDGANRWKQVWHVTLPGMRMIIVLMMVLSLGNVLNAGFDQIFNLYSKAVYESGDILDTFVYRLGLIDAQYGPATAVGLFKSIISTMFISVSYWLAYRFADYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF70</accession>
    <name>F7KF70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254415.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04514"/>
    <dbReference type="EnsemblBacteria" id="EGN35824">
        <property type="protein sequence ID" value="EGN35824"/>
        <property type="gene ID" value="HMPREF0994_04514"/>
    </dbReference>
    <dbReference type="GeneID" id="29725437"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4930"/>
    <dbReference type="eggNOG" id="ENOG5033FK0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135494_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="14013" checksum="F6AC76D6713E7D94" modified="2011-09-21" version="1">MGKKVLLYEFKGIRLGQVHKALEKLPFEIRVVERQEYWMTLGYLAGLEGSPALGKRYDGPGMEQEMVVFAGFVGDDIDKTLKAFRENGLAGVGLKAVLTETNKNWNSLQLFEELKKEHAQMHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFA7</accession>
    <name>F7KFA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04536"/>
    <dbReference type="EnsemblBacteria" id="EGN35305">
        <property type="protein sequence ID" value="EGN35305"/>
        <property type="gene ID" value="HMPREF0994_04536"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4953"/>
    <dbReference type="eggNOG" id="ENOG50332G5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113258_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046088">
        <property type="entry name" value="DUF6106"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19601">
        <property type="entry name" value="DUF6106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="164" mass="18606" checksum="D219B57F57122F5D" modified="2011-09-21" version="1">METYVECMVQKKPSGAMTALKILLIGIAAVTGLLGIMGLIVFLIIAVVAGVGAYFVNLNANLEYEYLYVDKQLTVDKIMARTRRKKVETFDMERMEILAPIKSWHLDDYKNRQLKEVNYSSGVEQQPDIRYCMIYNGEKRVIFEPNAAMVTAIKSVAPRKVFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFD7</accession>
    <name>F7KFD7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254467.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04566"/>
    <dbReference type="EnsemblBacteria" id="EGN35335">
        <property type="protein sequence ID" value="EGN35335"/>
        <property type="gene ID" value="HMPREF0994_04566"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4984"/>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764481_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="366" mass="43261" checksum="D7721BAF9D67A2B9" modified="2011-09-21" version="1">MKQKWTEEEIWSWYKAQPWITGFNFIPSGAMNGGIWLLQDYDHERAYRESAKEIALAASLGFNSIRFFVPFYLWRVQHDSFMKNFEELLSLLDLYHMTMMPVLFNDCCVAKSKYTEPVLGPQPEPVPGYFGGTSVTPFDEDTQNGDIIGYDITDEPEMEPTVHAYVKELAQTYGQDKRILIWNIWNEAGNSQRMEKSVPLMKKVFEWMREEDVKQPLTADVWGAGAEHPYGWLKNPGIYADVERTAIELSDIITFHFYGDYAHSRMYIKCLKEYGRPMINTEWMHRPYRSIIQTHLPLWKKEKIGSYFFGFVNGKAQFNYVWEFIKNLPDIDTRLWMHDIFHSDFTPYDEEEIDVIKECNRDKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFK6</accession>
    <name>F7KFK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254536.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04635"/>
    <dbReference type="EnsemblBacteria" id="EGN35082">
        <property type="protein sequence ID" value="EGN35082"/>
        <property type="gene ID" value="HMPREF0994_04635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5061"/>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074768_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="208" mass="22767" checksum="14B12ADB451309D8" modified="2011-09-21" version="1">MIRKIIHIDEEKCNGCGLCAKACHEEAIGMVNGKAKLLRDDYCDGLGDCLPACPTGAITFVEREAAGYDETAVLENKKRKMQKEEGGISQLTQWPVQIKLAPVNAPYFNGASLLIAADCTAYAYGRFHEDFIRDRIVLIGCPKLDACDYTDKLTQIITGNNIRSLTVVRMEVPCCGGIEHAAVTALKNSGKFIPWQVVTVSTDGRILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFP5</accession>
    <name>F7KFP5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04674"/>
    <dbReference type="EnsemblBacteria" id="EGN34885">
        <property type="protein sequence ID" value="EGN34885"/>
        <property type="gene ID" value="HMPREF0994_04674"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="32741" checksum="C4DD51CB180B72B8" modified="2011-09-21" version="1">MEIKNICTFVKAAELGNFTKAAQELGYAQSTVTAQIQQLENELHVNLFERNGKRIVLSASGKEFLQYAYQIIKYESMAVEHFSLSGEPEGELNIGIMETICASEFVNLFQNFSLNYHQVSLNLQIVTTHQALDMLEKGKFDLIFLLDNKISRPDMVTAREYPVDISFFCASGHPLASQKDITLEQLLQEPFILTEKGCNYREVFESEVAARGQTLTCITEIGYTRYIIQAVSRRLGIGLLPAMTLSEALRMGTISLIQVQNYQIRMSIQVIYSNKRRISLPLRAFLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFQ7</accession>
    <name>F7KFQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254587.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN34806">
        <property type="protein sequence ID" value="EGN34806"/>
        <property type="gene ID" value="HMPREF0994_04686"/>
    </dbReference>
    <dbReference type="GeneID" id="29726968"/>
    <dbReference type="eggNOG" id="ENOG5033097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1479924_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="182" mass="21523" checksum="043207965F5C34D8" modified="2011-09-21" version="1">MIDIKELYIVNYCHPNCKPLQNIMRLPKKQAFEKAGELARKNPETNAFYRFADFENYYPRRLKADNIIYCLFIELGGKPKEKHPLSFALQNCRYLDNWFGNGTITRIPLKDIPDEYISFTYGDSSAMIEKTGNVKLITKQMLLDDILFFDGTIEEYLREIEKNYCYIEVQLWNDDVINAYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG83</accession>
    <name>F7KG83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04870"/>
    <dbReference type="EnsemblBacteria" id="EGN34497">
        <property type="protein sequence ID" value="EGN34497"/>
        <property type="gene ID" value="HMPREF0994_04870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5312"/>
    <dbReference type="eggNOG" id="COG4804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046640_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="29446" checksum="B49B00853338492C" modified="2011-09-21" version="1">MPKDLKIFNDSYFREWIKTLKQIIKQSQLKAAIHVNSELLQLYWDIGKEIVQRDIEAKWGSKIFATMSSELKDAFPGMEGFSVTNLKYMKRFFQFYSNDDEIGQQPVDQFEKLYSIPWGHQILLITKCKTVREAFFYVNKILENGWSRAVLLNFLETGLFERQGKAITNFSRLLPDTQSDLAKETLQKKKETDNETLGLLICKTKDDIMAEYSLEASSQPIGISEYKLKDLLPNDYVSSLPTIAEIEESLKNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGA3</accession>
    <name>F7KGA3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254737.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04836"/>
    <dbReference type="EnsemblBacteria" id="EGN34463">
        <property type="protein sequence ID" value="EGN34463"/>
        <property type="gene ID" value="HMPREF0994_04836"/>
    </dbReference>
    <dbReference type="GeneID" id="29727556"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081792_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="30099" checksum="DEED6AD9F514EE39" modified="2011-09-21" version="1">MKGLSIFSWFSYPLPLQKRLELIKNAGFDATSLWWGDEFEDKNHQPEMARRLGLEIDYVHAPAENPNALWLDNINGDSYLNLLLSCIEDCRRHDIPTAVIHVTRLSSRPPVTQLGIDRIKRLVELAEQKQVNLALENLDSISHLDYIYKELQSDRLGFCYDSGHENYNHPQADCLSRYGDKLFAVHLDDNWGDDDTHLLPYDGNIDWDTLKEKLKKCRDIPYLTLEVDFNRDHHKSLIYKDLSPAAFLSSAYQRLLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGD5</accession>
    <name>F7KGD5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254815.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04914"/>
    <dbReference type="EnsemblBacteria" id="EGN34204">
        <property type="protein sequence ID" value="EGN34204"/>
        <property type="gene ID" value="HMPREF0994_04914"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5367"/>
    <dbReference type="eggNOG" id="COG1787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101688_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="154" mass="17315" checksum="0ED5614493D592F6" modified="2011-09-21" version="1">MDQSSVIFISIMSAAGLAVLVFAAFLVSRRWKRRRRSQLMDEMEGHDFEYFCADLLRKNGFLDVEVTKGSGDYGVDILAEKDGVTYAVQCKCYNAPIGVKAVQEVYAGRDYYDRMVGAVMTNQYFTSAAVAAAGKLKILLWDRGYIDSMMEEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH26</accession>
    <name>F7KH26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255063.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05162"/>
    <dbReference type="EnsemblBacteria" id="EGN33195">
        <property type="protein sequence ID" value="EGN33195"/>
        <property type="gene ID" value="HMPREF0994_05162"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5642"/>
    <dbReference type="eggNOG" id="ENOG502ZBK5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144184_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="13813" checksum="D97F590DEB548AC4" modified="2011-09-21" version="1">MRLANGIVIDKEATFGALKFSALRREVHLQNEDGSVSEEIKERTYDLKSRGQGRMIQVSIPASVPLKEFDYNAEVEIINPVADTVATATFQGAEVDWYIKAEDIVLKKGAAMNPQPPKKDAPPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHD7</accession>
    <name>F7KHD7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255028.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05127"/>
    <dbReference type="EnsemblBacteria" id="EGN33160">
        <property type="protein sequence ID" value="EGN33160"/>
        <property type="gene ID" value="HMPREF0994_05127"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5603"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079578_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="268" mass="29242" checksum="AFFABD1542ABF98C" modified="2011-09-21" version="1">MKKFCDKLIQLRREKGYSQEQLAEYLEVSRQSVSKWEADKTMPEISKLIAISQLFHVSLDYLLIDSCEDRGDKKWEPASETEEIRQTINEVKDFLGYQKGFEYKSRANIGGIPLIHIKFCRYMGRIRMKDAAKGIIAVGNIAVGVVSAGFVSVGIFSIGMLSLGLLVSLGIVSIGALAMGVAAIGIVAGGVSSLGIYATGVAAAGKEIATGVSAAGKTAVAQQGEHLWGHNMTAVDDEVTREWVKSFLVTYNPKVPKWILDFLTLMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHJ4</accession>
    <name>F7KHJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255166.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05323"/>
    <dbReference type="EnsemblBacteria" id="EGN33058">
        <property type="protein sequence ID" value="EGN33058"/>
        <property type="gene ID" value="HMPREF0994_05323"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5815"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="228" mass="25360" checksum="066EDCCA8D7DBEB9" modified="2011-09-21" version="1">MDIQLHYVEQGSGFPLILLHGNGEHSGYFSHQIDYFQKKYHVYALDTRGHGASPRGNAPFTLEQFALDLKDFMDEKGIKEADILGFSDGGNVALLFALKYPGMVRRLILNGADLFPGGVKRSVQIPIIIGYKMVSFFSLFDKKVIAKKELLGLMVTQPSIDPGSLSSLTMPVLVIAGTKDMIRLSHTQLIARSIPDSKLSILEGDHFIAAKNWEAFNRSVDTFLTERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHJ6</accession>
    <name>F7KHJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05325"/>
    <dbReference type="EnsemblBacteria" id="EGN33060">
        <property type="protein sequence ID" value="EGN33060"/>
        <property type="gene ID" value="HMPREF0994_05325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063459_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="29273" checksum="855D11E4E2150349" modified="2011-09-21" version="1">MTHEEKMKLLIDEKYPLSAKYDPEWIYENKMGCQCLWLVESLSQIMTLKPGMRILDMGCGNALTSIFLAKEFGVTVFANDLWVSPTDNWKRICNAGVENLVFPIHGEAHNLPYADNFFDAVVCINSFQFYGTADNYLSDYMAHLIKPDGQFGLVVWGPDKEFTGKVPADIGEKWWPDFYYFHSLDWWKWHFEKTGLFSIEAGDDLAGDGVRVTRQWAKIMEKYDNTHNNEIMRWNRMVAKRNSYQADDFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHX2</accession>
    <name>F7KHX2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_05463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255306.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05463"/>
    <dbReference type="EnsemblBacteria" id="EGN32904">
        <property type="protein sequence ID" value="EGN32904"/>
        <property type="gene ID" value="HMPREF0994_05463"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5973"/>
    <dbReference type="eggNOG" id="COG1966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010531_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="388"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="564" mass="60659" checksum="70A484B832A3FAD3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHY2</accession>
    <name>F7KHY2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05477"/>
    <dbReference type="EnsemblBacteria" id="EGN32918">
        <property type="protein sequence ID" value="EGN32918"/>
        <property type="gene ID" value="HMPREF0994_05477"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1460534_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="154" mass="17485" checksum="5EF30032E82F4DE3" modified="2011-09-21" version="1">MRKKEKQVTFFLFSLPAVLCYGIFFILPLILGLYYSFTDWNGIAKGFQFIGMENYMKILRDRKSYSSILFTVKYAVLLSLLILLISLFLGLLLNQKVKGIKFIKTIYFFPAVMSPIIIGLIFNEIYYRALPALGKAAGIGILSKSLVSDTRTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI62</accession>
    <name>F7KI62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255348.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05541"/>
    <dbReference type="EnsemblBacteria" id="EGN32366">
        <property type="protein sequence ID" value="EGN32366"/>
        <property type="gene ID" value="HMPREF0994_05541"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6057"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="318" mass="35820" checksum="3656764A0BA00011" modified="2011-09-21" version="1">MGNDNTLVKVENLTKTFRIKRNVFLKAVDNTSFEIKSGETLGLVGESGCGKSTLGRCILRLIEPTGGTVEYNGTSMQALKGEELRQMRKKMQMVFQNPYSSLNPRMTIMDSVKAPLDVFNTGSKEEREQRVKEIMSVVGLDSKYLYRYPHEFSGGQRQRIVIARALISNPGFIVCDEPVSALDVSIRSQILNLMRDIQNEFGVAYLFISHDLSVVKHISNRIAVMYLGQIVEISDVDRLYEEPLHPYTQALISAIPIPDVGSKRERIILTGDIPSPIFPPTGCRFHNRCRYATERCRKECPTLKDCGIGHQAACHLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIA7</accession>
    <name>F7KIA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05586"/>
    <dbReference type="EnsemblBacteria" id="EGN32411">
        <property type="protein sequence ID" value="EGN32411"/>
        <property type="gene ID" value="HMPREF0994_05586"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6103"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808234_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="352" mass="39934" checksum="3029D7ACD811679B" modified="2011-09-21" version="1">MEDMRALFEKMRAKMDMVRSVFGEENLAAVPLFEECLCYPVEQLAELAKMAAEIEELDSPEEIRERLGGFRELRIKIEGMRTDYPKIMLWPENKIPALTEYTDNTAFRYNHNPDFAPFMYEMLVPEDVTPKGAVILCAGGDHGFTVLCEGYQVAVDFNRMGYQCFLLLNRTNMNPWSGSEAGADAARAIRIVRANAGKYRVKENQIAFAGFSNGGLTGEACIQYYSGEQKMSDVFPGYEEDTLDTISGAMDAFLCIYGPRMNQDTFDYDRAVYPPVFHALGLEDFNIDNMNKLYTELISHGITVEIHTFSGVPHGQAGRKLMDGCVKYPNFETWEVLADQFLTNIFMNRHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KII0</accession>
    <name>F7KII0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255466.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05659"/>
    <dbReference type="EnsemblBacteria" id="EGN32283">
        <property type="protein sequence ID" value="EGN32283"/>
        <property type="gene ID" value="HMPREF0994_05659"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6184"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="6">
        <location>
            <begin position="143"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="542"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="690" mass="78432" checksum="C4A4DB6DACD7B152" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIX9</accession>
    <name>F7KIX9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-proFAR isomerase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255584.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05808"/>
    <dbReference type="EnsemblBacteria" id="EGN31884">
        <property type="protein sequence ID" value="EGN31884"/>
        <property type="gene ID" value="HMPREF0994_05808"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6351"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN31884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="29120" checksum="4E1F8059D1828000" modified="2011-09-21" version="1">MEFRPCIDVHNGKVKQLVGGSVADISDSAQENFVSEKDGAWYARLFQEKNLKNGHVILLNKKGSPYYESSKEQVLNALRAYPGGLQAGGGITAENAYEYLDAGASHVIVTSYVFRDGTISYENLNRLLENVGKKKLVLDLSCRKKDGDYYIVTDRWQKYTRVTLNEDVLDMLASFCDEFLIHAVDVEGKVCGIEKELVALLGRWNRIPITYAGGIRSLEDIRSIKELGRNRIHITVGSALNLYGGKLDFDKVQAYAEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ01</accession>
    <name>F7KJ01_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="3 8">3.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Invertase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_05830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Enables the bacterium to metabolize sucrose as a sole carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="3 8"/>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255606.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05830"/>
    <dbReference type="EnsemblBacteria" id="EGN31458">
        <property type="protein sequence ID" value="EGN31458"/>
        <property type="gene ID" value="HMPREF0994_05830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6379"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001528_7_0_9"/>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="10">
        <location>
            <begin position="28"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="11">
        <location>
            <begin position="338"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN31458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="490" mass="55345" checksum="63EB07A1BC409A8E" modified="2011-09-21" version="1">MSSNLDRARSYEGKVGKQIPDGQKCVFHLTPEVGWMNDPNGFSLYQGEYHLFYQYHPYSSVWGPMHWGHQKTRDFIKWEQLPCALAPDTEYDGQGCFSGSAVEHEGKHILMYTGVLDRVEADGSHTLRQTQCIAVGDGVNYEKLPANPVITADTLPEGSSGEDFRDPRIWKEGNTFYAAVGSLGADGSGQIALFSSQDAEEWRFESILDANGKRYGKMWECPDFFPLDGKQVLIVSPQFMRAEGLEFHNGNNSIYFVGTYDREKRSFLRGEARSVDCGLDFYAPQTVETEDGRRVMVGWLQSWDNYMTPEDFLWSGMMTIPRELEIREGRLIQNPVRELENYRQKEVSCKGIRLSEQQGSLELDGIRGRVLDMIVEADVSRSASFTIHLAVGEGCETTISYEKGKGTLTTDRTCSGLKKDLLCTRSMYVDTKEGKLKLRLLLDKYTVELFVNDGKQAMTSLIYTPLEAEGISFSCKGETVLDITKYEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ13</accession>
    <name>F7KJ13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05842"/>
    <dbReference type="EnsemblBacteria" id="EGN31470">
        <property type="protein sequence ID" value="EGN31470"/>
        <property type="gene ID" value="HMPREF0994_05842"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622254_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356957" evidence="2">
        <location>
            <begin position="29"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="440" mass="48333" checksum="E11761EE65D20139" modified="2011-09-21" version="1">MKRMKVAAICLAVMMTFTGCGGNNSSGNVSSTSEHETNAKESSQQESVQKNSTAKADTVINIWIAGSGEKSMDDAYKTVLNSYCENHEGVGYEITYIPWSDYFTKLNTGLAGASGPDIFMLGYGQIGSVQRAGNLLNLSEYIPEDWDGYEDFYENILDICKMDDSYYALFKPSNRNFFYRKDIAEQNGVTEEDLHITSPQDFLSLVEKMTVKDDKGNVQVYGMEVDPDSEQELFTYLGMFSEHPLFWEDDYTAAFASEECINALTFMNDIYKTGNASLKDANEGSSGLASGVAAMCIGANSEYVTADNAFPGNIGVVKDDMNTLLIGDYLAVNAATKNPEVAADMFLHMFSEESLQVFAETAGQYSGRKSLDGAFTAINPDYENIVAMYANSFSYGKPMHPNFSECAAFLRTAIESSFSGIAPKDALEEGKTNWDSVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ21</accession>
    <name>F7KJ21_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05850"/>
    <dbReference type="EnsemblBacteria" id="EGN31478">
        <property type="protein sequence ID" value="EGN31478"/>
        <property type="gene ID" value="HMPREF0994_05850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6401"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018711_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="6">
        <location>
            <begin position="14"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="699" mass="80194" checksum="745BAD96B2A9BBD7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJB0</accession>
    <name>F7KJB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell filamentation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255728.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05952"/>
    <dbReference type="EnsemblBacteria" id="EGN31580">
        <property type="protein sequence ID" value="EGN31580"/>
        <property type="gene ID" value="HMPREF0994_05952"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6515"/>
    <dbReference type="eggNOG" id="COG2184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080158_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="191" mass="22518" checksum="3CE69BEC78ED0CB4" modified="2011-09-21" version="1">MSDRIYCYPDSDVLMNKLNIHDAEKFQEAERKLTMLRLIDLLDRPVAGKFDFKHLQTIHKYIFQDIYPWAGKVRSVDIAKSNMFCKVQFIETQADEIFGKLKNDCYLEGLPKEKFAKKAAYYFSEINALHPFREGNGRTQREFIRQLAYQSGYILHFSAISEQEMVQASIDSFVCNYKKMEALFIKIIKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJD1</accession>
    <name>F7KJD1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255706.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05930"/>
    <dbReference type="EnsemblBacteria" id="EGN31558">
        <property type="protein sequence ID" value="EGN31558"/>
        <property type="gene ID" value="HMPREF0994_05930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6489"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="548" mass="64313" checksum="10C2BBB986E4D49C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJD3</accession>
    <name>F7KJD3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpiA</name>
        <name evidence="3" type="ORF">HMPREF0994_05934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255710.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05934"/>
    <dbReference type="EnsemblBacteria" id="EGN31562">
        <property type="protein sequence ID" value="EGN31562"/>
        <property type="gene ID" value="HMPREF0994_05934"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6493"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="27136" checksum="BD279139F019A6C5" modified="2011-09-21" version="1">MENKEKQKKAAAMAAASYIQDQMTIGLGTGSTALYLIHEAGSMIRAGRRFQAVATSEAAETLAVSLGIPVIRPEETERVDLAIDGVDEIDGSFCAVKGGGGALLREKIVAQKAEQVIWIMDESKPVKRLGTFPLPVEVLPFGAEWAAEAIRAMGGKAVCRMKDGRTFFTDNGNMILDVVMKEDTDLREAAKEIRQIPGVLETGIFDRICSRIIIGTGNGVRELVNPNPVKKNVRFEREQADGKMQESRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJZ9</accession>
    <name>F7KJZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_rhamnosid6H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255964.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06188"/>
    <dbReference type="EnsemblBacteria" id="EGN30681">
        <property type="protein sequence ID" value="EGN30681"/>
        <property type="gene ID" value="HMPREF0994_06188"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6776"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030429_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="323"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="569" mass="65744" checksum="FCF7786B4477F1DD" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK01</accession>
    <name>F7KK01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06190"/>
    <dbReference type="EnsemblBacteria" id="EGN30683">
        <property type="protein sequence ID" value="EGN30683"/>
        <property type="gene ID" value="HMPREF0994_06190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6778"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="33714" checksum="F034C334A4ABCE0A" modified="2011-09-21" version="1">MNKKKRMSLKEKTQLKWGYFFIAPAIIGLVCFNFGPMLFSMWLSFTKWDVITPQEFIGIKNYVNLFKDPLVIKSLKVTAYYTLLSVPLVTCIPLLIAMLLNTKVKGLSVFRTIFYIPSIVPVVASSAIWMYIYNPMYGLLNSIIKSFGGHTHNFIFSPKEVIPSLAVMAVWAAGNTVVIYLAGLQGVSKQLYEAAEIDGAGGFAKFRKITIPMMTPIIFYNFVMAIIGSMQTFTQSYIMTDGGPSNASLFYSLLVYRTAFKQSQMGYSAAMSWILFLIIAVLTAFVFKTSDNWVIYENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK80</accession>
    <name>F7KK80_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256035.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06259"/>
    <dbReference type="EnsemblBacteria" id="EGN30528">
        <property type="protein sequence ID" value="EGN30528"/>
        <property type="gene ID" value="HMPREF0994_06259"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6860"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN30528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="248" mass="28997" checksum="9E972A44D0925B54" modified="2011-09-21" version="1">MPLKAAICDDEPEQAGMLERYIKEWSVSSDIKIETRIFPSAEAFRFVWEEEKDWWLILLDIQMEGEDGVSLAKYLRGEDEKLQILFITALPDYIEEGYDVSALHYLIKPIRRDKFFQCLDKAAKKEEEESYLLLTTVQGEKVRAAQKEIMYMEAFAHTVQIHTKEEILEVRCGINTLEEQLEGKNFIRCHRSYIVGLAYAARIKKTELLLDDGTSVPVSRRLFQEVNRAFVAYYRREESGEYGTEERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKA1</accession>
    <name>F7KKA1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256050.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06280"/>
    <dbReference type="EnsemblBacteria" id="EGN30199">
        <property type="protein sequence ID" value="EGN30199"/>
        <property type="gene ID" value="HMPREF0994_06280"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="32533" checksum="9B374DD02A361CBA" modified="2011-09-21" version="1">MRKKLSGEAVFQVVDILLMCLFIFLIIIPIFTVVMTSFVSEAEIARRGTFIIVPEKFDFSAYKMLFASGKNIVRAYSNTLFRVIVGTGLNLMVTISLAYGLSKDNLKGKTVITGFVFFTMLFSGGLIPTFILVKGLGLIDSRWSMVLPCLVNTWNLLIMRNFFYAIPKSLEEAAVIDGANDIQILTKVVLPLSKASIATIGLFYAVSHWNAWFDAMLYINKTPLLPMQNILRNIITAASSIGDLGAEAYNSLDVVPPSQSIRAATIVITTLPILVVYPFVQKYFVKGVMVGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKA7</accession>
    <name>F7KKA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256056.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06286"/>
    <dbReference type="EnsemblBacteria" id="EGN30205">
        <property type="protein sequence ID" value="EGN30205"/>
        <property type="gene ID" value="HMPREF0994_06286"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9SY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908206_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024787">
        <property type="entry name" value="EcsC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12787">
        <property type="entry name" value="EcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="31312" checksum="BD681211FBC7CC48" modified="2011-09-21" version="1">MFFQRESSRIKISCEKELMYIAKQEERLKKAVLRKAAGGPSVFVWKEKLEQKIPAKLYENLRTAFGKAFSIVFEQGTGVIEKTLPKENLIKDYEVQNYAVELKGTRRELKQLRRKASASEVRDIAVTSAEGIGLGALGIGLPDIVIFIGFILRGIYETALHYGFTYDTPEEKLLILKMMEASMSQGEEWIKTNNEVDMFLVKSKNTEHTEAALFLQIGKTADVFALDMLLAKFIQGLPLIGILGGIGNPVYYSKIMRYVQLKYHKRYLLEILKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKW3</accession>
    <name>F7KKW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256254.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06492"/>
    <dbReference type="EnsemblBacteria" id="EGN47503">
        <property type="protein sequence ID" value="EGN47503"/>
        <property type="gene ID" value="HMPREF0994_06492"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364145" evidence="2">
        <location>
            <begin position="33"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="560" mass="61738" checksum="5E4F58FF07CB5B24" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL81</accession>
    <name>F7KL81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256364.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06610"/>
    <dbReference type="EnsemblBacteria" id="EGN47066">
        <property type="protein sequence ID" value="EGN47066"/>
        <property type="gene ID" value="HMPREF0994_06610"/>
    </dbReference>
    <dbReference type="GeneID" id="29724764"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040274_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="506" mass="57805" checksum="B3DE3B9496EDD0B8" modified="2011-09-21" version="1">MRRSLNSKRNIISGLVQQIIGIILPFINRTAVLWILGAEYQGLSSLFNSILSVLSMAELGLSSAIVYSMYAPIAEGNTEKVNALLNYFKRAYLVIGTVITTLGLLLMLGLPSLIKGDIPADINLYALYLLYLANTTSSYFFFAYRSTVLSANQRSDVINNVHSIIKLLSCISQFLLLMIFRNYYAYVILIPIFTTLSNLIIAIFSKKVFLQYRPVGKLDNETRQGITKQVSGLMINKVGDVARNSFDSIVISSMIGLITVAVYSNYYYIFSCLYNIMLIITNSMGASIGNSIAKEGQRKNYQDFKRLSFCFSWLTGWFTICLLCLYQPFMKVWTGEGLLLPEKDMILFCCYFYLINCNNIRNVYFAGNGLWWKAKHLFILEAIGNLVLNFVLGYLLGITGILLATIITIFVFNFYSRSKLLYQCYFTEYMVSQFWKMHLIFMCATLVNALVCYGTTMFIKLDGIAALMIYGVICAMLPNVIYFLLYRKWRLFEESLPWIKRIIRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL90</accession>
    <name>F7KL90_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4422 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46970.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06619"/>
    <dbReference type="EnsemblBacteria" id="EGN46970">
        <property type="protein sequence ID" value="EGN46970"/>
        <property type="gene ID" value="HMPREF0994_06619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065769_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025536">
        <property type="entry name" value="DUF4422"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14393">
        <property type="entry name" value="DUF4422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4422" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46970.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="29646" checksum="2D68CC8E5EE74DB5" modified="2013-09-18" version="2">MYIPLHVGAAAKLDNDGNPLDFDYVKDDSGQNISSLNYRFGTQTGLYWIWKNVDSEYKGLVHYRRHFVGKHPNKKDIVGSAITFEELRPLLKKYKVFTPKKRHYYIESLDSHYAHTHDGSHFRIVRDIIQKDCPEYLHAFDTVMKRTWGYMFNMMIMKNELMDDYCSWLFNILFQVAGSIDANTLSDFDSRFCGRISEILFDVWLEKKVEDSIVKKDEIKELPYMEQVNWIFKIKAFLAAKFLKQKYGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLH7</accession>
    <name>F7KLH7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system, N-acetylglucosamine-specific IIBC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HMPREF0994_06715</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256468.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06715"/>
    <dbReference type="EnsemblBacteria" id="EGN46639">
        <property type="protein sequence ID" value="EGN46639"/>
        <property type="gene ID" value="HMPREF0994_06715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7344"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019866">
        <property type="term" value="C:organelle inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015572">
        <property type="term" value="F:N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010974">
        <property type="entry name" value="PTS_IIBC_nag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01998">
        <property type="entry name" value="PTS-II-BC-nag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="409"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGN46639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="485" mass="51434" checksum="FE1EBBF8E81EC98F" modified="2011-09-21" version="1">MMKYLQRLGKSLMLPVACLPVCGILMGVGYILAPAAMAGEVAGFTAGGVAYTIGLFLIKAGGALIDNMAWLFAIGVAVGMSDDNDGTAGLAGLVSFLMITTLLSSGTVAGLTGADADPAFAKINNQFVGILAGLIGATCYNKFKGTKLPDALSFFSGKRAVAIVTAMFSILASAILFFIWPLLFGGLVKLGESFLGMGAVGAGIYAFFNRLLIPFGLHHALNSVFWFDVAGINDLGNFWGNTGTYGQTGMYMTGFFPFMMFGLPAACLAMYHTAKSNKKKVVYGLLASAAFCSFFTGVTEPIEFSFMFLAPGLYLVHALLAGITAGITVALPVRAGFSFSGGAIDLVLSSFTPLAENPWLVLPIGIVVGILYYVIFRFVITKFNLKTPGREDDDLEAEKSVVLSNNDFTAVAKVVLEGIGGKENVKSLDNCITRLRFEINDYTKVDEKKIKSAGVAGIIRPSKTSVQVIVGTKVQFVADEMKKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRY6</accession>
    <name>S2KRY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EPC05042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360338.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07315"/>
    <dbReference type="EnsemblBacteria" id="EPC05042">
        <property type="protein sequence ID" value="EPC05042"/>
        <property type="gene ID" value="HMPREF0994_07315"/>
    </dbReference>
    <dbReference type="GeneID" id="29729761"/>
    <dbReference type="eggNOG" id="ENOG5031IU6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494100_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="531" mass="59573" checksum="104CC0F2F4C83884" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVN0</accession>
    <name>S2KVN0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EPC05045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360294.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07294"/>
    <dbReference type="EnsemblBacteria" id="EPC05045">
        <property type="protein sequence ID" value="EPC05045"/>
        <property type="gene ID" value="HMPREF0994_07294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="385" mass="43602" checksum="906AE2C6930B7984" modified="2013-09-18" version="1">MGSFIYLDDFLKEHVKNGPAGCGCAVVQNDKLLYEGYYGYADLEKKKIITPDTVYRQFSTTKVIICTAAMMLFERGRFLMDDPLYEYFPEWKETMVADTGEDGGIYIRAAKRPIQIRDCFSMAMGIGYGGEDYTHQMMEKVRRNLAETVGDYTLRQDIYAMSQVPVRFDPGTHFLYGFGHELVAGLIEVVSGKKVSDFLQSELFEPLEMNSTGYRYFGDIRERMVTPYSRREDGSMVPVKGMFDHRHEPDAKYEAGGAGLFSTVRDYLNFSQMMACGGVYKGRNIIGRKTIDLMRTNQLNEQQLKDFSGSYLAGYGYGYGVRTMLSPGSGSNTSVGEFGWTGYMGTYIAIDPSEKAAVVYMHNLEPNMEEYTHHRVRNMAFGALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVS6</accession>
    <name>S2KVS6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07249"/>
    <dbReference type="EnsemblBacteria" id="EPC05100">
        <property type="protein sequence ID" value="EPC05100"/>
        <property type="gene ID" value="HMPREF0994_07249"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064931_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018775">
        <property type="entry name" value="RlaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34817">
        <property type="entry name" value="PTHR34817"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10127">
        <property type="entry name" value="RlaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="349" mass="40995" checksum="63493CEE70E7729C" modified="2013-09-18" version="1">MSMKDFKALMNTGQYDFLRKEERLGKRIILLGLGGSYAYGTYQENSDIDFRGITLNMTSDLLGLTEFEQYEDDKTDTVIYSFNKMVKLLLECNPNTCEILGLEEEQYLIKTKLGQELLDQKGLFLSKRAAKSFGGYAGAQLRRLQNAIARDAVPQREREKHILNSVRNALEDFERRYGDFDRGSIRLYIDKAENPELETEIFVDADYRHMPLRDYENMWAVMHNVVRDYDKIGKRNRKKDDNHLNKHAMHLIRLFMMAVDILEKGEINTCRRQELDLLRKIRSGGFQREDKTFTPEFYDILEAYEKRMEKASRESILPDNPDMEKVEAFVEYVNRKAIEGGYLEGNTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>S2LK09</accession>
    <name>S2LK09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent Clp protease, ATP-binding subunit ClpX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_07107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359968.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07107"/>
    <dbReference type="EnsemblBacteria" id="EPC05258">
        <property type="protein sequence ID" value="EPC05258"/>
        <property type="gene ID" value="HMPREF0994_07107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="190"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="4">
        <location>
            <begin position="392"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="504" mass="56360" checksum="A40B6075EE9F13FF" modified="2013-09-18" version="1">MSDFDNREEDDQKEEGLEEVKDQETSDKKEEKKEYEDVCFICRRPESKAGKMYHLPNNICVCDDCMHRTMDAVSQYDYQGMLNNPELMNMLNNMNKDGKYPNISFVNLADLQGNDGIPNKQKIKKKKEKEKEKEADSVFNIRDIPAPHKIKASLDEYVIGQEQAKKIISVAVYNHYKRVVTNTMDDIEIEKSNILMIGPTGSGKTYLVKTLARLLDVPLAIADATSLTEAGYIGDDIESVVSKLLAAADNDVEKAERGIIFIDEIDKIAKKKNTTSRDVSGESVQQGMLKLLEGSEVEVPVGASSKNAMVPLATVNTRNILFICGGAFPDLEEIIKQRLTKQTAIGFNGELKDKYDKDPDILSRVIVEDLRNFGMIPEFLGRLPIICTLQGLTKEMLVRILKEPRNAILKQYQKLLSLDEVDLQFDDEALEAIADKATKKDTGARALRAIIEDFMLDIMYEIPKDDNIGRVTITKDYIEGTGGPAIQIRGAGYAITDKQAGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K321</accession>
    <name>F7K321_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00250"/>
    <dbReference type="EnsemblBacteria" id="EGN37889">
        <property type="protein sequence ID" value="EGN37889"/>
        <property type="gene ID" value="HMPREF0994_00250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.271"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081790_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="27154" checksum="53C1E451F880A816" modified="2011-09-21" version="1">MEKKITIRENTAEYMQELREWAGEARKGGLEEMAAFFRNRLGEYEEHMSMWNAAYKRIGTMIPEQTEKLLDLGCGTGLELDEISAARPFLQITGIDLSPDMLAVLANKHPQVRLIQADYFSYDFGASVYDMAVSFESLHHFKQDKKLGLYKRIYEALKEGGTFLEADYIACCEEEETLLMELCDSLREKEHIPEDVFVHFDTPLTWEHEREALCGAGFSEVELIDSIDGVTFIRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K368</accession>
    <name>F7K368_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multicomponent Na+:H+ antiporter subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250246.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00297"/>
    <dbReference type="EnsemblBacteria" id="EGN33438">
        <property type="protein sequence ID" value="EGN33438"/>
        <property type="gene ID" value="HMPREF0994_00297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="117" mass="13024" checksum="1E44EF43855C1C3E" modified="2011-09-21" version="1">MTWNYVEITGLLLFLIGFYGLIARRNIIKTILSLGIMDISVILFFLGIRFEAGMRPPIGESAAPAADPVPQALMITAIVIGAAVTAVGLMMFIALYHRYGTTNWKTAHEIRRKEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3D2</accession>
    <name>F7K3D2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250314.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33506">
        <property type="protein sequence ID" value="EGN33506"/>
        <property type="gene ID" value="HMPREF0994_00365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.395"/>
    <dbReference type="eggNOG" id="COG5015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137964_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="15098" checksum="35B5F3809A9A0BFB" modified="2011-09-21" version="1">MNRAVEFFKANPVQYLATVGRDGKAKCRPFMFCFEKEGRLWFCTNSQKDVYKDMQANPEIEVCVSDSSYAWIRVHGKAVFENDMQVKEACMDNPIVKGQYKTADNPIFEVFYLEDPHGVIADFSGNPPYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3E4</accession>
    <name>F7K3E4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250326.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00377"/>
    <dbReference type="EnsemblBacteria" id="EGN33518">
        <property type="protein sequence ID" value="EGN33518"/>
        <property type="gene ID" value="HMPREF0994_00377"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077618_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="172" mass="19774" checksum="8CE34ABDF8B1C4A6" modified="2011-09-21" version="1">MLHKTDPRGERGDKDKMKDKYRNLPTILFWLYIAAVLRITVFRPGFLPVELLKNGSINLTLFQGYVPLLKKGDWFRFLYLFVGNIIWFVPFGMYLEHKFREKRLWKTVLAGFLFSLTIESLQYLFGTGYSELDDLILNTAGVFAGAVFVKGIKRHAVRGGGKPYVNAEGKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3G3</accession>
    <name>F7K3G3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250345.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00396"/>
    <dbReference type="EnsemblBacteria" id="EGN33537">
        <property type="protein sequence ID" value="EGN33537"/>
        <property type="gene ID" value="HMPREF0994_00396"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.430"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="208" mass="23830" checksum="7ADEEEF7A4F0F28D" modified="2011-09-21" version="1">MDRQLIISVGREFGSGGHVIAEALAERFHLALYDSNLLEHIAQEKNIDHGELKKFDEKPKNKLLSRTVRGYSSSAQENLANMQFEYLRKKAADGESFVVVGRCAETKLKDFPGLISFFILGDREKKAERVMQVYGVSKEEAIHMMEREDWERKTYHNYYCKGKWGDSRNYDFSINSSRLGIEGTADILEGYVKTLANVCIHAKIKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3W0</accession>
    <name>F7K3W0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250488.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00539"/>
    <dbReference type="EnsemblBacteria" id="EGN44727">
        <property type="protein sequence ID" value="EGN44727"/>
        <property type="gene ID" value="HMPREF0994_00539"/>
    </dbReference>
    <dbReference type="GeneID" id="29723617"/>
    <dbReference type="eggNOG" id="ENOG5033KD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1756351_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036679">
        <property type="entry name" value="FlgN-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140566">
        <property type="entry name" value="SSF140566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="156" mass="18134" checksum="C862ADF38AA82341" modified="2011-09-21" version="1">MEEIFVFLTEYTEFLEKMEVTQQEKLDLLLSGDLKKIEQSIMVQQAMDKQLENLEQARMRLFQEHGVEGKTFRELIPLQPEARNGEGSSSCRQDWQLLYDRLQKAIDNIRYYNKKSQDFARSELIKAGSDAGTVDPSSGVYHPDYGGRKNMFSKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K408</accession>
    <name>F7K408_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250542.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00593"/>
    <dbReference type="EnsemblBacteria" id="EGN44781">
        <property type="protein sequence ID" value="EGN44781"/>
        <property type="gene ID" value="HMPREF0994_00593"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.645"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="27594" checksum="820F0B5DA841DAFA" modified="2011-09-21" version="1">MAVNIVLTNQKGGVGKTTTAASLAAGLVMEGKRVLALDLDPQGNLGFSLGLNADAEGTIYDLMKGNVDIREIICPTEYGDIIPSDITLSAGVKEFYEKGRESLLKEALSDIGDEYDYIIIDTPPALNILTINAYVASDYIIVPMSSEILSLVGLTQLKETVDSVRLSLNPQIRILGILLTKFNSRTRLANEVKEMAESVALQMDTALFDNKIRNSVSVSEMPAHGMSIFKYAPRSKPAEDYLCFVREVIERIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K451</accession>
    <name>F7K451_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_rhamnosid6H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250591.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00642"/>
    <dbReference type="EnsemblBacteria" id="EGN44830">
        <property type="protein sequence ID" value="EGN44830"/>
        <property type="gene ID" value="HMPREF0994_00642"/>
    </dbReference>
    <dbReference type="GeneID" id="29725920"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021578_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="125"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="456" mass="51663" checksum="1DD0DF57FE15C0E0" modified="2011-09-21" version="1">MKKYKYGNLEFSCSLSELNRGFSWAKEQALAYVHDGEDPVGLWYEAALPARDAFCMRDTAHHAQGAAALGLSAHTKNMLYRFAESISEEKDWCGWWEITKAGEPCPDDYDSDGDFWYNFPGSFEVIAACWQEYLRTGDRDFITDPVFSRYYELTCTRLVEYWDKDGDGLLEHYPEYGRRGLASYNEGDTAILTAGDMLASQWAAYGAYSEILERQGKEAEAAAYRQKQEVLKQRYLTEWYDDKVGRFYGAVLQDGSFYQGYYKEGNFLPIYFGILDGEGLLEKAYEQLVKNPPENVEGMSYMPQIFYACGDEKRGLEALKKLGDPNLPRREYPEVSFAYIGAVAGCVMGIEAAEGTIVTKSGIPEGETAEIRKLPVFGGTICVKQEGKTGSVFRNETGSTQIWKAVFEGECREMYLDGRKAAFENGRDSAGKPISFLFTEVMPMQEIKIQAMRWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4A2</accession>
    <name>F7K4A2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250618.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00669"/>
    <dbReference type="EnsemblBacteria" id="EGN44857">
        <property type="protein sequence ID" value="EGN44857"/>
        <property type="gene ID" value="HMPREF0994_00669"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.725"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049171_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="1">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="350" mass="40340" checksum="903584664231EF88" modified="2011-09-21" version="1">MDAIRIPIPSVGFHPPVYLCRRAGLPFIPDGRLDKPFWEKAEFTCDFADIEGKHMPLPRFVTRAKLLWDDENLYIGAQLEGDEIWGNVTERDDVIFRDNDFEIFIDPDSDTRQYYEFEMNVLNTVWDLFLPSAYRDGGNALNGYDIHGLRTAVSVCGSINSPGPENKSWSVEVAIPFAAITECLPEKRAPGAGEYYRINFSRVQWKVEKEDGCYRKLTAPDGNPLPEDNWVWSPTGVINIHYPELWGFVFFTEDGGEDGVCRIPEDEQRKWELRKLYYAQNIYHDLHGSWCGSLDTLRDILREYSPCEENRSLLPLDYTLETTSHTYEISCPSSEEGRRIVLLSDGRIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4C3</accession>
    <name>F7K4C3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250651.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00702"/>
    <dbReference type="EnsemblBacteria" id="EGN44051">
        <property type="protein sequence ID" value="EGN44051"/>
        <property type="gene ID" value="HMPREF0994_00702"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.761"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102849_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="177" mass="20024" checksum="E0F870F5DD4B75C2" modified="2011-09-21" version="1">MAFHSIKPVQMTENIFSLISKDWFLMSAEKEGRVNPMTVAWAAAGILWQKPVMMCAVRPERFTREFLDASDVFSLTVFDNSYRKMLGYCGTISGRDQDKVKESGLTVAHSGEVPYFEECRMAILCKKLCVTPLKEEDFLGDKEFTQKWYGGDNHADGTGGGYHLLYIAEITDILVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4S6</accession>
    <name>F7K4S6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250804.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00855"/>
    <dbReference type="EnsemblBacteria" id="EGN43407">
        <property type="protein sequence ID" value="EGN43407"/>
        <property type="gene ID" value="HMPREF0994_00855"/>
    </dbReference>
    <dbReference type="GeneID" id="29724004"/>
    <dbReference type="eggNOG" id="ENOG50303QB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112358_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="219" mass="25010" checksum="81B96351BD7F967C" modified="2011-09-21" version="1">MKQYTSLLKKDLFLMGNYLFFIPAITFVLPFFYYWRLPQYAEQKGTGLLILIIASIYSEFLAYEQIFLKDAECPRALSLLCSSPYRRSDIIISRYILFCLVFVATSIIYTGLSLVLAASFRLSPPEYAVAFFLNALLFSILTPLQHLFGFENSKFVLVIIIMASCFLLPLLLKTDLLEANWLNGLPVLPAFLFLLLLSVILLILSAGITVKIFQRKELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K553</accession>
    <name>F7K553_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250940.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00991"/>
    <dbReference type="EnsemblBacteria" id="EGN43300">
        <property type="protein sequence ID" value="EGN43300"/>
        <property type="gene ID" value="HMPREF0994_00991"/>
    </dbReference>
    <dbReference type="GeneID" id="29725111"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1082"/>
    <dbReference type="eggNOG" id="ENOG503221E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070588_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="31753" checksum="944BDF3B16262D4F" modified="2011-09-21" version="1">MEQSWLAANEEQKNLFDYFNWTGVPDIPEEILNSLARWVLLYDVPFPYMAVREEMLPPESIRFFFLDKSYIAALLDGAMSLGRSFTIDYQHDSRVIDKVMDRALCESSLIRPSLQKKERKPSEVGKNALSGAVSGFLLRSVMVSGWRGLEFKAFEEGNDKEPLRALRLETLGTEVLLGLYVNEIKKLVITQPPEGMHFGFSRKKDESDKFEKRVRSLKDGKLLEGESALADVVLQDSGNRVVNLSATVANIRDALGEGDINSALTALEMIQNPYTGEVVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K575</accession>
    <name>F7K575_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250962.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01013"/>
    <dbReference type="EnsemblBacteria" id="EGN43322">
        <property type="protein sequence ID" value="EGN43322"/>
        <property type="gene ID" value="HMPREF0994_01013"/>
    </dbReference>
    <dbReference type="GeneID" id="29724768"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036605_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018771">
        <property type="entry name" value="PocR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10114">
        <property type="entry name" value="PocR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="31983" checksum="9D460AF345493250" modified="2011-09-21" version="1">MEIVFDKKRLLPLLRDFHTITGLRVGVFDLACKEVAAYPVKLSGFCRLIRSRPEGLERCLACDRTALEHSGEKAPGGIHIYQCHAGLTEAAAPICNGEEILGFLMFGQMRRTSQPQGQCRKVIKDLSEMGIPAENLLSAFSCLPLADEEHILACARVLRACAVSVWLEDCIRLQCESLPRRAKQYITAHLDEPLSLERLCDALGTGKTMLCSQIKKQYGCTAGEMIRNARLDKARQLLERTDIPICTLAEQVGIPDYNYFTRLFRKHTGETPTAYRRRLRKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5K6</accession>
    <name>F7K5K6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4143 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01135"/>
    <dbReference type="EnsemblBacteria" id="EGN42897">
        <property type="protein sequence ID" value="EGN42897"/>
        <property type="gene ID" value="HMPREF0994_01135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1245"/>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047370_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4143" evidence="1">
        <location>
            <begin position="51"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="29594" checksum="8A3FEB6E55360138" modified="2011-09-21" version="1">MPSALHDAAMQLYRQYLIVGGMPECVMQFAETKDYILVRHTQDTILASYLNDMSKYNNINEIKKTRLAYDNITVPLSRKNTRFQYKLIKKGGRASKFENAIEWLCLSGIVSQVYKVEQIKKPLENYRDNDAFKIYVSDLGLLCAKKDLAANDILYMIDELNDFKGGMTENYVNVQLNINGYKTYYWESERGAEIDFIIQRDGHLIPIEVKSADNTRAKSLRVYTDTYKPAYAIKLSSKNFGFEDGKKTVPLYAAFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5L2</accession>
    <name>F7K5L2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01145"/>
    <dbReference type="EnsemblBacteria" id="EGN42907">
        <property type="protein sequence ID" value="EGN42907"/>
        <property type="gene ID" value="HMPREF0994_01145"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1729010_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="151" mass="17298" checksum="F2FE38EA4CD2B96E" modified="2011-09-21" version="1">MVVLIMMAGYAALLILLSCMDYYLVADYQNRGRERESGLLAEAAEGVEKAAKDLDEILYDIYAKNKNFEALTTLQEETVEYSNAYELFDAMKSRLFLQENMHGVYIFYGAFQKCLFQCDKEIVSFDSQMEIKDRLSVQLSQSRNGGYGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K622</accession>
    <name>F7K622_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251250.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN42163">
        <property type="protein sequence ID" value="EGN42163"/>
        <property type="gene ID" value="HMPREF0994_01301"/>
    </dbReference>
    <dbReference type="GeneID" id="29725168"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1422"/>
    <dbReference type="eggNOG" id="ENOG5033Y1A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061360_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="381" mass="42700" checksum="962C10AC00A649DD" modified="2011-09-21" version="1">MSDKNKIGQSDEQEDFLSLEDDERMPSRPDNRQGTKNTSHKRTASNKSGSRPGSTRRKSGKRRKAETEQYVHYIIAGVLIIMVVVAAVKLIIWNIGKDSGYDPDNITSEFETEALDYIQPLDPELLAGREDDGITTIVALGNNPFSDERGKNGLAEMIAEKCDAVVYNCAFPDTYISMKNTEYSDNFPQDALSLYLTTASLCGSNYDLMEHAVGLLSDKDSAYTDALETLKSVDFSKVDMIVIMYDLNDYKDKRPVMDENNDINLLTWDGALNASIQQIQQKYPYIRLVVMSPAYGQFEDSDGKMINGDTEDFGNGVLPDYVLHEIDVAMANGVSILDHYYGTINEDDAEKCLTDGYHLNKMGRERVAARFAREIFNIGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K648</accession>
    <name>F7K648_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01327"/>
    <dbReference type="EnsemblBacteria" id="EGN42189">
        <property type="protein sequence ID" value="EGN42189"/>
        <property type="gene ID" value="HMPREF0994_01327"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668661_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN42189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="411" mass="46975" checksum="09CEA420E5469598" modified="2011-09-21" version="1">MSFISQKRFYRSIVVISVSMLFIYNLALTVFKLQTNDIVFMDFHARWQESAYLCKGLNPYKVNDLNSIDSIGIINPQMITVPWAWLIGMLINPGFLPYGIAKIIGVIIYIGTYLITSAVLANYWLNNIVNNRKKDLLWVIFPGFLLGAQIYWWWSIICGNQGAIIACIIIICLCLYKKHPIISGLLMTVAMVKTQLTAIFYVLLLLQKEYKLIFTSIISGLVSFLSVSLITKSTFVELLLQTFQSGSKLDGVFYGLFDVMKFFNAPIVLILFADIVCGLLYVLLYWKVFNNKNCTNIFVLFSGVAIASTFWFYKQPHDNIILAIPCIAYLYIAYVTDKRRDYFKCIINIFILVGAFYIQGAVQIIFRFFKCSIQPEMATSIGKTIYCICLIICGFSILKFKESFALTNIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K690</accession>
    <name>F7K690_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251327.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01378"/>
    <dbReference type="EnsemblBacteria" id="EGN42240">
        <property type="protein sequence ID" value="EGN42240"/>
        <property type="gene ID" value="HMPREF0994_01378"/>
    </dbReference>
    <dbReference type="GeneID" id="29725859"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1498"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="340" mass="39223" checksum="DD0539219C3E6218" modified="2011-09-21" version="1">MEEKLISIIVPVYNAQNYLKQCVDSIVNQTYNNLEIILVDDGAEDKSPEMCDAYAAADHRIEVIHKENGGLMSAWMAGVKKSRGDYLSFIDSDDWVETDMMEVMLQKTSGCPGEIICGNFVVERTGGVTEHYHELPPGIYEGLDLEKKVKSRLLGNERRTISMSRCMKLFSRELIVDNLGFCNPEIKMGEDVNIVLPALLDCKRVIILEGALHYHYFYNDTSIVHKYDAHMYVGIRTLTDTIKEIFLAKNISDWESQWEEEKLFLFLLAVKNELRGGRMGYIERIRQICKDEKLNDVADRYKAEPEDKVNKLLIWVVKKPSEVRCMLGKMIFEVFDKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6E1</accession>
    <name>F7K6E1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251395.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01446"/>
    <dbReference type="EnsemblBacteria" id="EGN41920">
        <property type="protein sequence ID" value="EGN41920"/>
        <property type="gene ID" value="HMPREF0994_01446"/>
    </dbReference>
    <dbReference type="GeneID" id="29724774"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1576"/>
    <dbReference type="eggNOG" id="ENOG502ZC8C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038687_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025686">
        <property type="entry name" value="Glucos_trans_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14264">
        <property type="entry name" value="Glucos_trans_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="528" mass="59217" checksum="D9C00C02929955B1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6P0</accession>
    <name>F7K6P0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HPr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251499.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01550"/>
    <dbReference type="EnsemblBacteria" id="EGN42024">
        <property type="protein sequence ID" value="EGN42024"/>
        <property type="gene ID" value="HMPREF0994_01550"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1691"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="79" mass="8916" checksum="DE9DB3CBD7221DF2" modified="2011-09-21" version="1">MESVKICFDNADEVWKFVNTIRKFDGEYDLAMGSYTVDAKSILGVCALGTKKSLELKLVNPKGEENQLLTALHEYMVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K746</accession>
    <name>F7K746_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251588.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01675"/>
    <dbReference type="EnsemblBacteria" id="EGN41713">
        <property type="protein sequence ID" value="EGN41713"/>
        <property type="gene ID" value="HMPREF0994_01675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1829"/>
    <dbReference type="eggNOG" id="COG2155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179993_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37304">
        <property type="entry name" value="PTHR37304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="70" mass="7680" checksum="2556E2279F17008D" modified="2011-09-21" version="1">MGNKGLDYTALVITVIGAINWGLIGLFRLDLVALIFGQMSWISRIVYVIVGICGIYLLTFFGRVGNGRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7D3</accession>
    <name>F7K7D3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01762"/>
    <dbReference type="EnsemblBacteria" id="EGN41575">
        <property type="protein sequence ID" value="EGN41575"/>
        <property type="gene ID" value="HMPREF0994_01762"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1923"/>
    <dbReference type="eggNOG" id="ENOG502ZC37">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107547_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="201" mass="23387" checksum="E2410E2156DA76C7" modified="2011-09-21" version="1">MGNKNSVKRENVFWNMDVYADCPQLEDDKYLMKLTSESDWQDLLKVYSDKDAVPFFNSDNCNGEDFYLTTEERMKEIIRMWRLSYEERGFVRWSIVDKQSGCVIGTIELFHRDAADYFTDCGLLRLDIRSDYEREEEIVRIVSLILEPAFELFRCGKIATKAVPGAAERIKGLKRLGFAAAEEKVIGHDGTRYGDYFVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7E7</accession>
    <name>F7K7E7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251689.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01776"/>
    <dbReference type="EnsemblBacteria" id="EGN41589">
        <property type="protein sequence ID" value="EGN41589"/>
        <property type="gene ID" value="HMPREF0994_01776"/>
    </dbReference>
    <dbReference type="GeneID" id="29727315"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363561" evidence="2">
        <location>
            <begin position="30"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="461" mass="50027" checksum="BF436754F3A7CB49" modified="2011-09-21" version="1">MKRKLTAKVLAVGLAISTILTGCGGAAKGEESKPVQTGTANEEAQSEEEKPAGAEAQADIGEVPTELTIYTYYADSAIAQVDRALEIMKETYPDLKINIEHRTDSDGSVLKTRAAVGELPDIFECTGQLTDILIKSGDLAELDSAIEEAGFFDKYLDGNFDVKKSADGHFYAISSTVPECCEVFYNKEVFERLGLAEPKNYEEFKAVVEALNADGIIPLALFAQQKWPGLQMFDMAVVAEGQPLGLTGLEDGSTKITDQEYLEAAKKLSELTSMGLIGKGALNTNASQAFELVETGQAGMLINGSWFFNDAAVGGYGDRIGYFEYNPFTDEGKEEETHWTESGGTGSMGGYAVSAKGKYAEYSKKVLLSFLEARDIANAELGSLSVLKEKVEPLEARAESYQHYADNLDKIQSTTKFEWSLNNQELIVALEDTCELLLTGLITPEDFIADLDEQIAEALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7E8</accession>
    <name>F7K7E8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01777"/>
    <dbReference type="EnsemblBacteria" id="EGN41590">
        <property type="protein sequence ID" value="EGN41590"/>
        <property type="gene ID" value="HMPREF0994_01777"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1939"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="36"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="527" mass="59518" checksum="844BA4945D7D8205" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7H1</accession>
    <name>F7K7H1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01800"/>
    <dbReference type="EnsemblBacteria" id="EGN41613">
        <property type="protein sequence ID" value="EGN41613"/>
        <property type="gene ID" value="HMPREF0994_01800"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="163" mass="18167" checksum="6A2BD36E0CDCC797" modified="2011-09-21" version="1">MKCIITTEGFGDMVFELYPGLAPVTVKNFVDTVNSGFYNGLAWCRIVKDYVIQAGSPDNDIMTDSEWHIKGEFAENGVPNPIPHKRGALSMARDDAYDTAGTQFFVVHKDAHKLDGRYAAFGQLVSGFEVLDRIADLPTYGPESWNKPLEMPVMTSIRIETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7H3</accession>
    <name>F7K7H3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01802"/>
    <dbReference type="EnsemblBacteria" id="EGN41615">
        <property type="protein sequence ID" value="EGN41615"/>
        <property type="gene ID" value="HMPREF0994_01802"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1967"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="321" mass="35685" checksum="B3DB8283C7D5B6DE" modified="2011-09-21" version="1">MMNEQNMLEVRNLTKHFKVGSKQIVHAVDGVSFTLKKGKTLGLVGESGCGKSTCARTIIRMYAPTSGQILLNGDDITELKQKQLKPYRKNMQMIFQDPYASLNARMTVRDIIAEPLIAHGVVRKKEDANELIYPMLERVGLTKEHSGRYAHEFSGGQRQRVGIARALILQPDLVICDEPISALDVSIQAQVVNLLKDFQEEKGVSYLFIAHDLSMVRYVSDDVGVMYLGQLVEVSESNEIYKNPLHPYTKGLLGSIPIANPKLARMKEKSGMEGDIPSPIDPPSGCRFHTRCPYAKDICSEQVPQLKDAGNGHMTACHLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7J2</accession>
    <name>F7K7J2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251734.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01821"/>
    <dbReference type="EnsemblBacteria" id="EGN41634">
        <property type="protein sequence ID" value="EGN41634"/>
        <property type="gene ID" value="HMPREF0994_01821"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1992"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="32854" checksum="0BC7A1A4BF45106A" modified="2011-09-21" version="1">MRTVKEISERTGISVRTLHYYDEIGLLKPTSYSEGGYRLYDDKALERLQQILFFREFDMPLLEIKEIMDNPELDRDSVLLTQKKMLEIKRDRLNRMIAGITDILKGENKMDFEMFSKTEIDEMYQAVVGNMKEEQLQVMKEKYGSLEKFREHFLENASGQDAQKNFRKVVEWYGNKDKAMEAVKNPAGTEVMEAYRNRIDGIYKKLAEKRGVDVSSFEVKSLIGELDFVSKQLYQMEDVKQLMLEIADSYENNPAMSESMDEQYGAGMAEYLGKAVREFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7N7</accession>
    <name>F7K7N7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251844.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41336">
        <property type="protein sequence ID" value="EGN41336"/>
        <property type="gene ID" value="HMPREF0994_01931"/>
    </dbReference>
    <dbReference type="GeneID" id="29727979"/>
    <dbReference type="eggNOG" id="ENOG5032T9Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093166_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021509">
        <property type="entry name" value="DUF3169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11368">
        <property type="entry name" value="DUF3169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="248" mass="27935" checksum="BE67976C2DE6BF04" modified="2011-09-21" version="1">MKDNKNKSKSMGQILAKIVLWLVVGGAVGFFTSFLIMSVKKDTTDVMHIFYNGYLQYSFGYQAGFFVVLGAVAFIYYRKAGAAIRQGTYEEEDKANDYQNVTISANEINMVIQFLLFGLAMDMKNPNMLVCVILFVIFCTGIIIMEAVLIKQIKKIHPLKNGDVGDTNFNKRWMDSCDEAERMIIYKASYSTFQVMKSMLPIMEAVALLGKLMFGTGNFPIILICIIWGVHTGVYCFGSMKLEKEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7S4</accession>
    <name>F7K7S4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Holin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251882.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01969"/>
    <dbReference type="EnsemblBacteria" id="EGN41374">
        <property type="protein sequence ID" value="EGN41374"/>
        <property type="gene ID" value="HMPREF0994_01969"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2164"/>
    <dbReference type="eggNOG" id="COG1380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113736_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="121" mass="13634" checksum="040C86042CCE24B7" modified="2011-09-21" version="1">MKILYQIGIIFSICWVSQIVEKLLPFDFPASVIGMVLLFVLLSCKVLKVEHIREKSDFLLANMAFFFVPAGVSIINYFDVLRSAVWKLLFICLITTILTFGATAGSIKLTLKLMRKKKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7S5</accession>
    <name>F7K7S5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01970"/>
    <dbReference type="EnsemblBacteria" id="EGN41375">
        <property type="protein sequence ID" value="EGN41375"/>
        <property type="gene ID" value="HMPREF0994_01970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2165"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_12_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="214" mass="23116" checksum="A62101FC11CD4A70" modified="2011-09-21" version="1">MPDGQKHKTGGTGAVKCNNVTFDMLTENGCTKENGKADSEMKKVLVVVDMQNDFIDGSLGTVQAQGIVSKVISKIKSYPADCIYATRDTHGEDYLESSEGKNLPVVHCVKGSKGWEIRPEVAEAMPQAVILDKPTFGSTDLAKLLYRENEKEELEIELVGLCTDICVVSNALLLKSFLPENRIGVDASCCAGVTPESHEAALATMKMCQIMVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K813</accession>
    <name>F7K813_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphonate ABC transporter, permease PhnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251973.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02060"/>
    <dbReference type="EnsemblBacteria" id="EGN41465">
        <property type="protein sequence ID" value="EGN41465"/>
        <property type="gene ID" value="HMPREF0994_02060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2261"/>
    <dbReference type="eggNOG" id="COG3639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064254_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="268" mass="29324" checksum="F2F7C419FE9611DF" modified="2011-09-21" version="1">MAELAGKRAETFPVSRERVNRTFLVFLGVAVVFCGCMAYLEISPSDAVKGFPAFARFFAVKFLPASFKNIRAYVPAVVDTVLYAVVATYLSTALSFLFGLLMSEKTNPITPLRLLCRGIISFLRNVPVLVWASILVYMFGVGEIVGLLALIIATLGFLSRSYAESISEIAGSHLEALQTAGASYGQVLVHGLIPEFLPSWINWTLFSFEINIRASAILGMVGAGGIGVLIQTNLKLFKYQEACAIILVVIVIVLLTEFVTNKIRRMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K826</accession>
    <name>F7K826_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251986.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41478">
        <property type="protein sequence ID" value="EGN41478"/>
        <property type="gene ID" value="HMPREF0994_02073"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2273"/>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046274_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="241"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="432" mass="49711" checksum="3E889DF7080C60BB" modified="2011-09-21" version="1">MSKFLSYEERLIISQRIQENTSFGAIAKELGKDRTTIAKEIRKYSYDKKSGRPGYPYNPCKYRNSCKAKKICGANGCTHQSAYKCSLCSECTFHCPDFEEDICSVKRKPPYVCNGCRELPRCTLLKRIYDPADAHEMAHKTISESRTGILSNESDIARINKLITPLVKNGQSLHQIYTEHVDELMCSEKTLYNYVDAQLFEIRNIDLPRKVKYRPRYKQPEFKVDRGCRLGRSYSDFQKFLEKEPETTIVQMDSVIGKPGGKCLLTIHFVETSFMLAFLRESNTAGSVIHIFQALDRILGAKDFNRLFPVILTDNGSEFSNPKEIEYRDTVPMRRTSIFYCDPSCPYQKGACEVNHELIRRILPKGESFDDLTQANISLMMNHINSYKRKKLNNRSPYDAFSFYYGEDLLKKLGCSPVAAENIILKPKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8A7</accession>
    <name>F7K8A7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251793.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01880"/>
    <dbReference type="EnsemblBacteria" id="EGN41285">
        <property type="protein sequence ID" value="EGN41285"/>
        <property type="gene ID" value="HMPREF0994_01880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2060"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034085_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363797" description="NlpC/P60 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="293"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="407" mass="44792" checksum="C5ED03D9CFCEAF1F" modified="2011-09-21" version="1">MRKKFTSLILILILALSTTHTAYATSVSDLQKQRQEKENEKKGTQGQLDSLNDQINDLSGEKEDVEAQISGLTSQIAEIMASVSLLEDEIADTEEQIKQAQKDYDAAKEKEDAQYRAMKKRIQYLYEKGETSYIELLMAAKSWSDMLNKAEYVQEIYTYDRNMLDDYAATVKQVAALKESLEEQKSELQAAEYELEQEKASLQESLDEQKAIAADYDVQLAKAKQEAAAYKARIKQQNAEIQKLASAEQAKKAEEEAKRKAAEQKNNSSSQSSSGTAPPSAGGSKTVPPKMGSGTGSDIAQYACQFVGNPYVPGGTSLTNGADCSGFTQSVYRVYGYSLPRNSSSQRSAGREVSYEEAQPGDLICYAGHVAIYLGNGRIVHASSVKTGIKYGYATYKPILSVRRIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8H7</accession>
    <name>F7K8H7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02160"/>
    <dbReference type="EnsemblBacteria" id="EGN41067">
        <property type="protein sequence ID" value="EGN41067"/>
        <property type="gene ID" value="HMPREF0994_02160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2363"/>
    <dbReference type="eggNOG" id="ENOG5032YRK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110663_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="167" mass="18790" checksum="A7419B48AD1CFAAB" modified="2011-09-21" version="1">MAQTVRSRQSRSTGKSEYRRSVSRSAYVAGNTVRQIDVVEEIHKPRRQELSHAVKKNRDKAVYMNLGYVLFLTASLIVAGVVLIGYIRLQSEITASVKHIAAMESTLNSLKVSNDEEYSRIESSVDLDEIRRIAITELGMTYPDQNQIVTIPDEGSDYVRQLADIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Q5</accession>
    <name>F7K8Q5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_02250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252151.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02250"/>
    <dbReference type="EnsemblBacteria" id="EGN41157">
        <property type="protein sequence ID" value="EGN41157"/>
        <property type="gene ID" value="HMPREF0994_02250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2457"/>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_9"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="10">
        <location>
            <begin position="116"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="143"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="430" mass="47966" checksum="344DE96A74FF64E7" modified="2011-09-21" version="1">MKQDMIVILDLGSTENTVVARAIRDMGVYSEIHPHDITVEELKALDNVKGIILNGGENRVVDGRPVDIDPALYGCGVPVMAIDHPTAQCGLRYPSIPKEEVLKDFVLGQCKAETNWNMKNFIEDQVELIRRQVGDKKVLLALSGGVDSSVVAAMLIKAIGQQLVCVHVNHGLMRKNESESVVEIFRDQLHANLIYVDATERFLGKLTGVADPEEKRKIIGGEFIRVFEEEARKLDGIHFLGQGTIYPDIIESGTKTAKMVKSHHNVGGLPEDLQFELVEPLKQLFKDEVRACGIELGLPAAMVYRQPFPGPGLGVRCLGAITRDRLEAVRESDAILREEFEKAGLDKTVWQYFTVVPDFKSVGMKNHARCFEYMVIIRAINTIDAMTASVEKVDWEVLEKITNRILAEVENVNRVCYDCSPKPPATIEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8V4</accession>
    <name>F7K8V4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02314"/>
    <dbReference type="EnsemblBacteria" id="EGN41221">
        <property type="protein sequence ID" value="EGN41221"/>
        <property type="gene ID" value="HMPREF0994_02314"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076060_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="43"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="33846" checksum="0FB622E798727320" modified="2011-09-21" version="1">MNKKLKKIAGGCILWFTGFTLAGCFSPGGERIVNEMVFDLNNISDLEIAYDEENVTFCDGRSEKLVIREYMTDDNRRYYANTEIQGKRLHISEGGRPLFKDGFSCRVEVFLPASYNRDLTVSTTSGVIDMTQADLMLDSLRAETTSGEIRLEQVKAACLDLETTRGILDLGTLLADQITIHSTEGRVNISRMEGNVNYTSTHGSLMVDAAVGAGIYQTSNDGLLQLRYEKADGDLQFYNKNGDILLTLPSSLAFELEAVSRNGSVSADFGKDEKEEKGWVKGKNGSAPYVKISLESRNGKLEIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K984</accession>
    <name>F7K984_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transporter A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252329.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02428"/>
    <dbReference type="EnsemblBacteria" id="EGN40827">
        <property type="protein sequence ID" value="EGN40827"/>
        <property type="gene ID" value="HMPREF0994_02428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="79" mass="8815" checksum="10FAA2364C467EE1" modified="2011-09-21" version="1">MTLYEGRVGGQYLVEDIKIESEISRRLQALGLIEGTRLKMLNRKGNGSLIIYVRGTRLALGRHITSGIDVKEAEEIEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9A8</accession>
    <name>F7K9A8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">HMPREF0994_02456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252357.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02456"/>
    <dbReference type="EnsemblBacteria" id="EGN40855">
        <property type="protein sequence ID" value="EGN40855"/>
        <property type="gene ID" value="HMPREF0994_02456"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2690"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_9"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="11"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="377" mass="42861" checksum="38D9135AA4F0B8E8" modified="2011-09-21" version="1">MYRLLKQEGRAKRGELETVHGTVQTPVFMNVGTVAAIKGAVSTEDLEHIKTQVQLSNTYHLHVRPGDKIVKQLGGLHKFMSWNKPILTDSGGFQVFSLATLRKIKEEGVYFNSHIDGRKIFMGPEESMQIQSNLASTIAMAFDECAPAKAERDYVENSVARTTRWLERCKTEMSRLNNLDDTINKKQMLFGINQGAVYADIRIEHAKRIRELDLDGYAVGGLAVGETHEEMYHILDETVPYLPAEKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNGRHGHLYTNHGKINLFNAKFELDERPIEEGCDCPACRRYSRAYIRHLLKAKEMLGMRLCVLHNLYFYNTMMEEIRDALDRGEFASYKKAKLEGMSQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9F0</accession>
    <name>F7K9F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252408.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02507"/>
    <dbReference type="EnsemblBacteria" id="EGN40906">
        <property type="protein sequence ID" value="EGN40906"/>
        <property type="gene ID" value="HMPREF0994_02507"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2748"/>
    <dbReference type="eggNOG" id="COG3962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="221"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="442"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="643" mass="70524" checksum="20E97A38A36DF976" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9F4</accession>
    <name>F7K9F4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosose dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-keto-myo-inositol dehydratase</fullName>
            <shortName evidence="4">2KMI dehydratase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iolE</name>
        <name evidence="6" type="ORF">HMPREF0994_02512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O</text>
            <dbReference type="Rhea" id="RHEA:14065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17811"/>
            <dbReference type="ChEBI" id="CHEBI:28446"/>
            <dbReference type="EC" id="4.2.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IolE/MocC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.44" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252413.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02512"/>
    <dbReference type="EnsemblBacteria" id="EGN40911">
        <property type="protein sequence ID" value="EGN40911"/>
        <property type="gene ID" value="HMPREF0994_02512"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2753"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00076">
        <property type="reaction ID" value="UER00144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050114">
        <property type="term" value="F:myo-inosose-2 dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01672">
        <property type="entry name" value="IolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023952">
        <property type="entry name" value="IolE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030823">
        <property type="entry name" value="IolE/MocC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04379">
        <property type="entry name" value="myo_inos_iolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="5">
        <location>
            <begin position="37"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="34049" checksum="CEC9D72A5B6B88E0" modified="2011-09-21" version="1">MFDKNKVKLGIAPIAWTNDDLPDLGKENTFEQCVSEMALAGYTGSEVGNKYPRDPEVLKKALQLRGMEICNQWFSCYLITKPFEEVEKEFRAQLTFLKEMGAKIIGASEQSHSVQGQQDVPVFGHKYVMNDEEWDIFCSGMNRLGKIAKEEYGISLTFHHHMGTVVQNPDEVERMMENTDPAYVSLLYDTGHFTYCGADPLEMVRKYAGRIRHVHLKDIRPEIVEKIKREKLSFLDGVRLGAFTIPGDGCIDFDPIFKVLEDTGYEGYMLVEAEQDPAKANPLEYAIRARRFIAEKTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Z8</accession>
    <name>F7K9Z8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252582.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02681"/>
    <dbReference type="EnsemblBacteria" id="EGN40664">
        <property type="protein sequence ID" value="EGN40664"/>
        <property type="gene ID" value="HMPREF0994_02681"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2935"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="34513" checksum="98355095323E9275" modified="2011-09-21" version="1">MSKSSAVIHKEKRINAISTRTNVLLLCILAAFALLCVLPVLLVVIVSFSSEQSIFRNGYTFFPTEFSLNAYRFFLRLGDQIIRSYGITLFVTIFGTLFSLAVTTMLSYVLSRPDYRYGRILTFLLLFTMLFNGGMVPSYMVNTQLLGLRDSVWALIFPMSLNAFYVIVLRTFFKSIPLEIIEAAHIDGAGEFRTFLRVVLPLSKPGIATIGLFTVIAYWNDWFLGMLYIFETKKYPIQTLLQSMQNSLEALTQSSANALEYAEMAKNAPTDSGRMALTVLVVLPVMLAYPFFQKYFVKGLTVGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAA8</accession>
    <name>F7KAA8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252859.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02958"/>
    <dbReference type="EnsemblBacteria" id="EGN40567">
        <property type="protein sequence ID" value="EGN40567"/>
        <property type="gene ID" value="HMPREF0994_02958"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3229"/>
    <dbReference type="eggNOG" id="ENOG502Z7PD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015927_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="543" mass="61167" checksum="3D580D15C8A7F159" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAC8</accession>
    <name>F7KAC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02754"/>
    <dbReference type="EnsemblBacteria" id="EGN40363">
        <property type="protein sequence ID" value="EGN40363"/>
        <property type="gene ID" value="HMPREF0994_02754"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3012"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363607" evidence="3">
        <location>
            <begin position="18"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="226"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="542" mass="59404" checksum="8BD60F803870E193" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAD3</accession>
    <name>F7KAD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02759"/>
    <dbReference type="EnsemblBacteria" id="EGN40368">
        <property type="protein sequence ID" value="EGN40368"/>
        <property type="gene ID" value="HMPREF0994_02759"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031H1T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198202_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="50" mass="5628" checksum="765F40211AC9BACB" modified="2011-09-21" version="1">MRDMWKLVGIVVFSIAFGMILTVLISNRLASLIVAIILLLVSYNVIFCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAK5</accession>
    <name>F7KAK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40440.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02831"/>
    <dbReference type="EnsemblBacteria" id="EGN40440">
        <property type="protein sequence ID" value="EGN40440"/>
        <property type="gene ID" value="HMPREF0994_02831"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZJN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178417_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40440.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="9915" checksum="15067B516DA61474" modified="2013-09-18" version="2">MVKPGKEKIACMLRSYHLTHLSDAGKAEKILHEMDGLEGMHSARISEDLKELDVDAEEGKFSFIMDHTVNICRKIADECEISFMFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAQ2</accession>
    <name>F7KAQ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="10" type="ORF">HMPREF0994_02878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252779.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02878"/>
    <dbReference type="EnsemblBacteria" id="EGN40487">
        <property type="protein sequence ID" value="EGN40487"/>
        <property type="gene ID" value="HMPREF0994_02878"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3147"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="9">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="620"/>
            <end position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="882" mass="100369" checksum="82A2FC6794AD7199" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAU2</accession>
    <name>F7KAU2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40349.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359709.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02971"/>
    <dbReference type="EnsemblBacteria" id="EGN40349">
        <property type="protein sequence ID" value="EGN40349"/>
        <property type="gene ID" value="HMPREF0994_02971"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="276"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40349.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="470" mass="54026" checksum="5F0DB5D89F311FE6" modified="2013-09-18" version="2">MYQKKSNLQNLIIISLDCLVLILSLGIANYLRHQKFFKGLNNPTDMKVLIAIFLVVFLVINLFKNWYKQMLLRGPFQELLEIIKMNLVTLAGATFALYFTRVIDEYSRKVLLYFVFIDVLLMFLVHQLYKRYLPVFYRVAGNARQLLLVATAKEAPALVTEMKNIKDYSYQIKGIILLDGDEKEVGGIPVVASGKDLIEYCLSAPLDEVIFCTDRQTQEDRKDDLENLAAMGLTIHLEVPVLELTEAPQRILSQFGQFHTITYANKVAPFGQLMLKRLIDIAGAVVGSLILFILTIFLAPVIKLDSPGPVFFAQKRVGRNGRIFKMYKFRSMYIDAEERKKELMAQNEMDGLMFKMEDDPRITRVGKFLRKTSLDEFPQFINILKGDMSLVGTRPPTLDEFEHYKSYHKKRLSFRPGLTGMWQVSGRSDITDFEEIVRLDVEYIDNWSVSLDLKILIKTFLAVFSESGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAZ8</accession>
    <name>F7KAZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252928.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03027"/>
    <dbReference type="EnsemblBacteria" id="EGN40204">
        <property type="protein sequence ID" value="EGN40204"/>
        <property type="gene ID" value="HMPREF0994_03027"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3307"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="222"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="330" mass="38046" checksum="3F27ADBBA2BE31C2" modified="2011-09-21" version="1">MNQELLDKLKVISPEEEQILAGETEVQKSIYTAADDFIVDGSQMLDAGKLIDIRPHTRFVHFPRHKHNYIEIIYMCSGTTTHIINDTTKVTLDTGDLLFLNQNATQEILPAGKEDIAVNFIVLPEFFDRTFLMIDERSALQEFLVGALKKNRSFTDYLHFHVSQVLPIQNLVENLIWSLVYRQPNRRNINQTTMGLLFIQLLNHTDKINQDDPGQHEQNMVFTAMKYVEENYKTATLDELSAQLKEPAYYLSRLISRMTGKTFKNLLQTKRLNQSAFLLTTTTLPVEEIIASVGYDNTSYFHRIFRAQFGMTPRSYRLSHDSVSSQDTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB94</accession>
    <name>F7KB94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253024.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03123"/>
    <dbReference type="EnsemblBacteria" id="EGN39953">
        <property type="protein sequence ID" value="EGN39953"/>
        <property type="gene ID" value="HMPREF0994_03123"/>
    </dbReference>
    <dbReference type="GeneID" id="29728774"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3415"/>
    <dbReference type="eggNOG" id="ENOG50330Z5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071454_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="197" mass="21187" checksum="5922A313A3821DCA" modified="2011-09-21" version="1">MGDRLASWKKKLTKENMAILALLGILLMVIALPVKKTENARDETGLSDTGSDTMKTSETEKDDGDGSYTQEVENRLEALLSSMDGVGEVKVMVTLSSSVEQVVEKDVPYSMDTTKETDSAGGSRDVVNSKQEETTVYVTDQAGNKTPYISKTLEPAIEGVTVVAQGGGNAVVQKNITDVIQALFGVEAHKIKVVKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBD8</accession>
    <name>F7KBD8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">HMPREF0994_03172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03172"/>
    <dbReference type="EnsemblBacteria" id="EGN40002">
        <property type="protein sequence ID" value="EGN40002"/>
        <property type="gene ID" value="HMPREF0994_03172"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3465"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="26622" checksum="8F812F0410669B9B" modified="2011-09-21" version="1">MSSGQNERLMMKRILLKLSGEALAGEKKTGFDEGTVRKVALQIKQLTENNIQVGVVIGGGNFWRGRTSENIDRTKADQIGMLATIMNCIYVSEICRAEGMQTAVLTPFECGTFTKLFSKDRANKYFEKGMVVFFAGGTGHPYFSTDTGVVLRAIEVEAEVILLAKAIDGVYNDDPRTNPKAEKYTEVSIDEVIEKNLQVVDMTASILARDNKMPMWVFGLNEENSIVNTVNGKFNGTKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBP0</accession>
    <name>F7KBP0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Na_H_Exchanger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03277"/>
    <dbReference type="EnsemblBacteria" id="EGN40107">
        <property type="protein sequence ID" value="EGN40107"/>
        <property type="gene ID" value="HMPREF0994_03277"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3581"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="14"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="435" mass="46042" checksum="BA1062138C174155" modified="2011-09-21" version="1">MDFNVMDILFDCAVILLATKLLGLLSRRLGLPQVVGMIIAGLLIGPAIIGQFHPGGFMGIIHPTDAEMDVLQSFSQIGVVFILFSSGLETDFRELKRSGAASSAIAVMGVLVPVALGTAGALLFMGWPGKAASHGMLMNALFVGSILAATSVGITVETLRELGKLNTRVGTTILSAAIIDDVLGIITLSVITGMNGGGSVGITLLKAAGFFVFTIGAGLLLRWLFKVLVKKYPHRRRTGIFALVMCFMYAFCAEEFFDIAAITGAYMAGLMLSGLDDTSYVDRKVVVSGYMIFTPMFFAYIGISADFSHFRPSGLVFAAVFVLLGLVGKIIGCGGIARLFHYNSREALTIGCGMIARGEVALAVYATGQSMIYYENGVLAGIDPLVATIFLIVLSSIFCPVLLKLVFKNQISSNEGEAHRATIGTEAIENAGGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC58</accession>
    <name>F7KC58_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253326.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03425"/>
    <dbReference type="EnsemblBacteria" id="EGN39932">
        <property type="protein sequence ID" value="EGN39932"/>
        <property type="gene ID" value="HMPREF0994_03425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3744"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="286"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN39932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="549" mass="61123" checksum="CCF1CAEC86188C3A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC77</accession>
    <name>F7KC77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253357.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03456"/>
    <dbReference type="EnsemblBacteria" id="EGN39529">
        <property type="protein sequence ID" value="EGN39529"/>
        <property type="gene ID" value="HMPREF0994_03456"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3777"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="34607" checksum="24D35F8BD4869476" modified="2011-09-21" version="1">MNGNSLGYRIKKDFRRNWSLYLLVLPVIIFYAIFMYKPMYGAIIAFKDYTPAKGVFGSEWVGFENFNRFFGSPYFGRLLRNTLLLSIYSIIFGFPAPIILALLLNEVKGRKFKKISQTITYLPHFISLVVACGMIKDFCLTTGLFNDIIVLFGGTRVPLLQDPAYFRTIYTVSSIWQEVGWGSIIYLSALSGVDSQLYEAASIDGAGKWKQLLHVTLPGIAPTIIIMLILRMGSLMSMGYEKTILLYNPSTYETADIISSYVYRAGLIEQDWSYSTAIGLFNSVINCILLFITNQISKKTTESSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCB3</accession>
    <name>F7KCB3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03492"/>
    <dbReference type="EnsemblBacteria" id="EGN39565">
        <property type="protein sequence ID" value="EGN39565"/>
        <property type="gene ID" value="HMPREF0994_03492"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3818"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009998_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="8">
        <location>
            <begin position="31"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="6">
        <location>
            <begin position="172"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="7">
        <location>
            <begin position="296"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN39565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1196" mass="136305" checksum="51B35831437A4954" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCH4</accession>
    <name>F7KCH4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cobalt transport protein CbiM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Energy-coupling factor transporter probable substrate-capture protein CbiM</fullName>
            <shortName evidence="11">ECF transporter S component CbiM</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cbiM</name>
        <name evidence="12" type="ORF">HMPREF0994_03555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CbiM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253456.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03555"/>
    <dbReference type="EnsemblBacteria" id="EGN39464">
        <property type="protein sequence ID" value="EGN39464"/>
        <property type="gene ID" value="HMPREF0994_03555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3884"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_3_0_9"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01462">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018024">
        <property type="entry name" value="CbiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43627">
        <property type="entry name" value="PTHR43627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00123">
        <property type="entry name" value="cbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 11" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN39464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="247" mass="26357" checksum="3EFA39314B2BEE00" modified="2011-09-21" version="1">MTEKQKKVLKLSIAFAVSFAVYPAANAMHIMEGYLPVGYCIAWGVICLPFLVKGFFNIRKQFQENKKAITMLAMAGAYIFVLSALKIPSVTGSCSHMTGTGLGAILFGPSTVSILGIIVLLFQAILLAHGGLTTLGANTFSMAIAGPFVAYGIYLLCRKCKVNKMAGIFLAAFLGDLFTYCVTSIQLALAFPSTHGGVFASALEFLGIFAPTQLPLAVVEGILTVLIMMALENYAKPELKSIGFFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCI1</accession>
    <name>F7KCI1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253465.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03564"/>
    <dbReference type="EnsemblBacteria" id="EGN39473">
        <property type="protein sequence ID" value="EGN39473"/>
        <property type="gene ID" value="HMPREF0994_03564"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3894"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043516_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="480" mass="53595" checksum="D540BBE42608D5FF" modified="2011-09-21" version="1">MSNYNSQEQTIYRNLAGKIQLGFYDGGERFPSAKEIASGYQVSYCPAQRALKMLEKDGLIKLCRGKATQILAKPYEDYLGNPVFLQRSAALLDLCEGLKLISPAICFHSLRALDYEAFSESPKGEGTANAVRSLYLQFDQALHAIGSQTALNLYYDVGSFVGSAFLDIFCSPCGKEETMRLWQEIENEYRECAIQFKTNDGEAFQKRLDRLNHLFFDRIIQYLKDLPPQEGEQIPFVWEPHKGRTRYCDFVAIDMICKISQKFYPVGTLLPNGAVLADIYHVSEITIRRTISLMNQLGVTQTFNGVGTRVISEGDASIPRKLKDLTLDSNLRSFLDAIQLLTILAEPVMCHTFPHIPADTLDRLAEAVGQKGQKKAMVAAIGMVLQTVVRFSPLASLREIYSKLTHLLLVGSILRLDETGEETVPGWPEIASSIREGCRSSRSDILAHACRTLFENCFASTKLSLLEIGVQGVEDIVGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCM2</accession>
    <name>F7KCM2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253509.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03608"/>
    <dbReference type="EnsemblBacteria" id="EGN39517">
        <property type="protein sequence ID" value="EGN39517"/>
        <property type="gene ID" value="HMPREF0994_03608"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN39517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="28698" checksum="351719F4EAE3E439" modified="2011-09-21" version="1">MPFITICDDSLQDLMYMEKMLYHYRERNPDSLFAVNKYSDPGKLYARIEEGEYADIYILDILMPDKSGIELGNLIRAQKRKSIIMYTTASVDYALEAYQVFACRYLVKPLEEAVFQEAVQYALMQAELNREPVFRIKTAEGVLTFAYSGILYVECRQRSLYLYAKDGTCIHSIVLRGTFEKAVEELLDSWTFVQIHKSYVVNMEYISRYKQDSVTMENGQILPVSRNKAPWVKRKYLGFMTDKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCR8</accession>
    <name>F7KCR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253548.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03647"/>
    <dbReference type="EnsemblBacteria" id="EGN39019">
        <property type="protein sequence ID" value="EGN39019"/>
        <property type="gene ID" value="HMPREF0994_03647"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3979"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="34558" checksum="D645DA7A0EC6324B" modified="2011-09-21" version="1">MSREKVLKTKMHHSFGDNMLAVVCYIIFALCALICIYPFYYIFINTISANDLSARGVILFWPKGLHFKNYLSALRIDGLFQAAKISVLRTIIGTVGTVGASAFLGFMFTQDNMWHRKLWYRLVVATMYFNAGIIPWYLTMRNLHLTNNFWGYIFPAVVSPFYIILTKTFVESVPKELQEAAQIDGAGIMKIFFKVMLPVIKPIMATVAIFSAVNQWNSFQDTLLLVTDTKLYPLQFILYQYLNQASSLAGLANTNNSASMAAAVATSQTPTSVRMTVTIIVVIPIILVYPIFQRYFVKGIMIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD67</accession>
    <name>F7KD67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253697.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03796"/>
    <dbReference type="EnsemblBacteria" id="EGN38767">
        <property type="protein sequence ID" value="EGN38767"/>
        <property type="gene ID" value="HMPREF0994_03796"/>
    </dbReference>
    <dbReference type="GeneID" id="29729424"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4135"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463027_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="558" mass="64069" checksum="1AD4C57DAE2003ED" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDJ7</accession>
    <name>F7KDJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_03942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253843.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03942"/>
    <dbReference type="EnsemblBacteria" id="EGN38707">
        <property type="protein sequence ID" value="EGN38707"/>
        <property type="gene ID" value="HMPREF0994_03942"/>
    </dbReference>
    <dbReference type="GeneID" id="29729440"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4293"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN38707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="582" mass="66825" checksum="F0210AF272D58E0F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDS4</accession>
    <name>F7KDS4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253904.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04003"/>
    <dbReference type="EnsemblBacteria" id="EGN37692">
        <property type="protein sequence ID" value="EGN37692"/>
        <property type="gene ID" value="HMPREF0994_04003"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4360"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_13_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="126"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN37692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="336" mass="37852" checksum="243691C043C4F47E" modified="2011-09-21" version="1">MTLSDYLSDKRAVLLTCLAGGLFFSVLLYLYGIAPQEMFLLWICYAGIVSGSLCRGYVILKKRLLYLQSLLDSLDRKYLMAEVAKKPVSSAEKVYFRMIKEALKSMTDEVSQAKRLNEEYRDFIEQWIHEIKIPITGIQLLCENNKSDTIRKIMSQTEQIGRYVERVLFYARLGNVEKDYFIKELSLRDCVMEALAANKQFLIQNGVSVSTEKVRDTVYSDEKWVVFIMNQIIINSVKYSGGRPPVIAVESTDMGGYVVLAVTDNGAGIKESEIDRIFDKGFVGSNGRAGKGATGIGLYLCRQLCLKLGISIEAQSEQGQYTTLRLSFPKSGHLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEC2</accession>
    <name>F7KEC2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254102.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04201"/>
    <dbReference type="EnsemblBacteria" id="EGN36481">
        <property type="protein sequence ID" value="EGN36481"/>
        <property type="gene ID" value="HMPREF0994_04201"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4584"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN36481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="202" mass="22356" checksum="D0B26C3370A0DA96" modified="2011-09-21" version="1">MSRRVIFATGNEGKMREIRMILDNPDLQVLSMKEAGIDADIVEDGSTFEENALIKARAVAESACEGDIVLADDSGLEIDYLGGEPGIYSARYMGEDTSYRIKNANLISRLDGVPKEERTARFVCAIAAVIPGEERQELVVRGTIEGYIGWEEKGSNGFGYDPIFYVDEYGCSTAELDSETKNRISHRGNALRMMKERLDGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEC3</accession>
    <name>F7KEC3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36482.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04202"/>
    <dbReference type="EnsemblBacteria" id="EGN36482">
        <property type="protein sequence ID" value="EGN36482"/>
        <property type="gene ID" value="HMPREF0994_04202"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032119_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36482.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="380" mass="43271" checksum="DAF1484D1E83B6B9" modified="2013-09-18" version="2">MIAPCHFGLEAVLKKEIIDLGYDVIQVEDGRITFFGDEEAVSRANVFLRSAERILIKVGSFHAETFEELFQGTRSLAWEEFIPADGKFWVAKAASVKSKLFSPSDIQSVMKKAMVERLKGIYRVGWFEENGASFPVRVFLMKDEVTVGLDTTGESLHKRGYRKLTAKAPIAENLAASLIMLTPWRGDRILVDPFCGSGTFPIEAAMMAANMAPGMNRSFTAESWTEVVGRRNWYDAVDEAGEMVDLNVDTDIQGYDIDEKMVAVSRENARLAGVEKLIHFQRRPLSELRHPKKYGFLITNPPYGERLEEKEALPALYREIGERFVGLDSWSMYLITAYENAERDIGRKADKNRKIYNGMMKTYFYQYLGPKPPKRQKQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEK9</accession>
    <name>F7KEK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254189.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04288"/>
    <dbReference type="EnsemblBacteria" id="EGN36100">
        <property type="protein sequence ID" value="EGN36100"/>
        <property type="gene ID" value="HMPREF0994_04288"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4682"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="267" mass="28533" checksum="6502785458E2A011" modified="2011-09-21" version="1">MGILNDFSLEGKVALVTGASYGIGFAIATAYAQAGATIVFNDIKQELVDKGIASYKEEGIEAHGYVCDVTDEAAVCDMVKKIEEEVGVIDILVNNAGIIKRIPMLEMSADQFRQVIDVDLNAPFIVSKAVIPGMIKKGHGKIINICSMMSELGRETVSAYAAAKGGLKMLTRNIASEYGEFNIQCNGIGPGYIATPQTAPLRELQADGSRHPFDQFIIAKTPAARWGDTEDLKGPAVFLASDASNFVNGHVLYVDGGILAYIGKQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEN1</accession>
    <name>F7KEN1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36122.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359917.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04310"/>
    <dbReference type="EnsemblBacteria" id="EGN36122">
        <property type="protein sequence ID" value="EGN36122"/>
        <property type="gene ID" value="HMPREF0994_04310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Melibiase_C" evidence="6">
        <location>
            <begin position="356"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36122.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="441" mass="50258" checksum="366EE6EEC1846908" modified="2013-09-18" version="2">MDKNKFAQTPPMGWNSYDYYDTSVNEEQVKANADYMAAHLKQFGWEYVVVDIQWYAYGAGSMRDKHQYIPFSKLEMDEYGRLLPCPERFPSAAGGAGFRPLADYIHSLGLKFGIHIMRGIPRAAAQQHLPVLGSSQTADEIANPSSICGWNPDMYGLRREEEGSQAYYDSLFALYAQWGVDYVKCDDICNTNLYKENPYSAAHEIEMLHKAIEKSGRPVVLSLSPGPALIEKAWHYEKYANMWRITDDFWDKWELLLNMFERCELWQNHVKEGCFPDCDMLPLGFLGKGFGEERQTNFTKDEQVTMMTLWCIFRSPLMLGAEMTKLDDWTLSLLTNQKVLALLEEGHHGVQVERDKTHAVWAGREEKEGRVYAALFNFCEEETEVSVSLEDLYASVSAANEEGAKLTAEELWTGETAECKDGKVTGSVKAHGAKLYLLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF20</accession>
    <name>F7KF20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04461"/>
    <dbReference type="EnsemblBacteria" id="EGN35771">
        <property type="protein sequence ID" value="EGN35771"/>
        <property type="gene ID" value="HMPREF0994_04461"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4873"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="31719" checksum="B4BDFA5B5FAE865C" modified="2011-09-21" version="1">MGMNVKKTMGTICYHVFVCAFGLVMIYPVLWMITGSLKNNTEILNGSLGLIPPNWRWDNYATGWRGFGGVGFGNFFRNSFIVTVISTAATVISSGCVAYAFARIKYKGRNIWFALMLATMMLPGQIIMIPQYIIYNKLGLVPSFVPLVLPHFFGQAFFIYQMMQFMASIPRELDEAATIDGCSKYSIFTRIILPLLKPSIVTTIIIQFYWKWDDFMGPLLYLSQPKTYTVSLAIKLFADSTSTTDYGAMFAMSTLSLLPVFLIFLFFNKYLVEGISTSGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF55</accession>
    <name>F7KF55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254398.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04497"/>
    <dbReference type="EnsemblBacteria" id="EGN35807">
        <property type="protein sequence ID" value="EGN35807"/>
        <property type="gene ID" value="HMPREF0994_04497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="26026" checksum="A3B968A5505EFD83" modified="2011-09-21" version="1">MKRFVLVTGSGKGLGLHVTKKHLEIGDQLYVLEHTITEELTALQHSFPTSLTVKQCDLGKTDEVTAAMQELTDRGTSLDIIYNIAGIFFPSDRVPLVQTDIDRCMLLYNVNALGPLRVLKNAVSLLKSGTVVMNVTSESGSVGDCVRTAEYGYSMSKSAFNMASKIFSNQFAEKGVRVFCYHPGWMKTDMGGEGALLSPTSLSPEEAADAIMDITLHPAQIPPEVMYLDYQKNPLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFJ9</accession>
    <name>F7KFJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254529.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04628"/>
    <dbReference type="EnsemblBacteria" id="EGN35075">
        <property type="protein sequence ID" value="EGN35075"/>
        <property type="gene ID" value="HMPREF0994_04628"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5052"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_8_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363978" evidence="2">
        <location>
            <begin position="28"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="466" mass="51138" checksum="A03DA86264B4728C" modified="2011-09-21" version="1">MKKKALAIALSLCMTAGLMAGCGSKPAENTAAEPSEQAAEQQKAETEAAAPETEAAEMEKEPVELTLWVTSRNTDDFSEEIENQFLEEHPWITLNKVVKEGDPGNEFYQGVAAGNAPDLANCSFTMMNSYMAAGILEPLNAYTDTWDEWGNFTKEYVDMFTKDGSVYGLPATVSPMLFGYNKALFEAAGVTEPPKTWDEAIEAAKKVNDPSNQITGYATLAAEWTEWFFQYYVWQAGGDLTKENPDGTAELTFTDPAVIEAAKYYQRLRSEGVLQSDLTLKFGDLVANFGLGKVGMMPFAGDWVSEAISNGIDPDDIGLCLPPAGPSGDQTTAIAGTCYVINAKSDQAKKDAAWEFISYYTSKAYLTAYFENLATKGAPNPMIIPRDDMSVTDFYEFPEEYKEVLEAAKVVGRLEFYGKADFGSYVDRAVQKILVDPNADPEKEFADAQKLCETEALDAFNEANKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFM9</accession>
    <name>F7KFM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254559.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04658"/>
    <dbReference type="EnsemblBacteria" id="EGN34869">
        <property type="protein sequence ID" value="EGN34869"/>
        <property type="gene ID" value="HMPREF0994_04658"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5088"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045643_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="466" mass="52746" checksum="EDC6542F916D6D9C" modified="2011-09-21" version="1">MKRIKIGFLPTRRSIFSAPDAIKYANLTRKRLEELGIEFVDITDVNEEGLFYDEADREKIQEKFRTEKVKGIFMPHCNFGTEYVCARLAKEMNLPVLLWGPRDERPDKDGIRLRDSQCGLFATGKVLRRFRVPFTYMTNCRLTDPEFERGIRNFLAVCNVVDVFHHTRILQIAPRPFDFWSTMCNEGELLEKFNIQLSPIPMPELTAEMKKVKEEGLEVEKVVAYCMDKMCVKIKPEELVNVAALKVAMKNLADKYGCNAIAIQCWNALQGEIGIMPCAANSLLNEEGIPVVCETDIHGAITAVLVEAAGMDENRSFFADWTVRHPDNENGELLQHCGPWPISVAREKPVIGYPLAFDHPGAVEAQAKSGDMTLVRFDGDNGEYSLLLGNAKGVEGPYTKGTYVWVEVENLKRLEAKLVEGPYIHHCVGIHQDVVPVLYEACKYMGITPDLYDDKEEEVKAFLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFW4</accession>
    <name>F7KFW4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04743"/>
    <dbReference type="EnsemblBacteria" id="EGN34669">
        <property type="protein sequence ID" value="EGN34669"/>
        <property type="gene ID" value="HMPREF0994_04743"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5178"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="34401" checksum="73288D5F9728F8CE" modified="2011-09-21" version="1">MMNESPEKNNPRETVRLLTESQTRIALRLYYSGSESCAPGHFFGPAIRPHYLIHFIRSGRGKYICQDSIFELEKGDAFLILPGETTKYIADEKEPWEYSWIAFDGPDARTLLKHCGFTDTQVVYRSPDKESAEKLLAQTSVFENSFHENSQNLLEIMGNFYLLFSCMYQEQMPVPLLTPSRQSSPAGTLQELYFRQAVEYLKHNFSYPVKIEQLARQVGVSRTYLYKIFISHSGKSVQQYLQDLRLTAAMDMLKKSGRDITEIAYSCGFTDSPAFCRQFKKTTGLTPLQYRRAAGNYGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG87</accession>
    <name>F7KG87_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254775.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04874"/>
    <dbReference type="EnsemblBacteria" id="EGN34501">
        <property type="protein sequence ID" value="EGN34501"/>
        <property type="gene ID" value="HMPREF0994_04874"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5318"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="32025" checksum="DB2A8007199B391F" modified="2011-09-21" version="1">MNANLHSPEHMLQIEYIKHPQDYDMGSFHYHNAYELLFLQEGEYTLITMDTAYTICKNQVSLIPPCCMHKSLGRAGNERTLMYFDDRFLNRYFTEKSRSLLLSCFRSGQLPLSPEAFSEALALLFQIRGFVHKNDYDAAYPAFVRILSLLDDSCRENILKTSDAEKKRGTENPPLIAEVITYINQNYSTIRCLDDISSHFYITKYHLCRLFRNATSSTVMDHLNSIRLFQACRLLENTSKSITDISYACGFHSSAYFSDLFKKALGMSPRAYRKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGM0</accession>
    <name>F7KGM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33794">
        <property type="protein sequence ID" value="EGN33794"/>
        <property type="gene ID" value="HMPREF0994_04999"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5460"/>
    <dbReference type="eggNOG" id="ENOG5032X8R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1608005_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="192" mass="22487" checksum="2B9B5784B582BDAA" modified="2011-09-21" version="1">MKGYLSNLHNIYKVYSEKSSKNIILYNMIFPLWLLWIIPSTWIVILPANFLIDLAVLLITMHCLKISGRKEIVKRSILKIWGFGFISDFIGTFFMFLVNIIDSFLDYRSPLTEWWYNNLTNAVTYNPLSTPAAFLWTILCILISGSCIFLFNYHFCLRKAVPDRILRKKLALSLAIFTAPYLFLVPTSWFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGP2</accession>
    <name>F7KGP2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254922.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05021"/>
    <dbReference type="EnsemblBacteria" id="EGN33816">
        <property type="protein sequence ID" value="EGN33816"/>
        <property type="gene ID" value="HMPREF0994_05021"/>
    </dbReference>
    <dbReference type="GeneID" id="29726499"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5484"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629569_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="9"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="43103" checksum="5FD39FB11BA2C369" modified="2011-09-21" version="1">MKFREDGTFHILHITDIQEIPEVAEDTLTLMRRALDAAKPDLVVFTGDQLKGYSKKFRKKPGQVEKTINRIMEPVVSRGIPFAVTFGNHDEQSGMTNDEQMEIYRNIPGCVDWLNSRGQEILHGTEEGTFAVGIRNFEETQTVMAVYLMDSRGDAPGGGYQTLNPRQVFWYKGARDTFEQEHGRLIPGIVFQHIPMPEYYRLLKKTDKKTKGAVRTYRTHANEYYVLDPEKYRSGSFKEAVSIPDNNAREFESFREKGDIFAVYCGHDHRNSFVGNCGGLDLGYTPSCGFNEYGDGVNRAAREFIFHEEDPSAYETRLLTYKDLVGGKPSRPFRDFAYSHIPATKEEAVAKIKKYLLFTGLAIAGVQAVRSVYKRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGW9</accession>
    <name>F7KGW9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe-ADH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05098"/>
    <dbReference type="EnsemblBacteria" id="EGN33131">
        <property type="protein sequence ID" value="EGN33131"/>
        <property type="gene ID" value="HMPREF0994_05098"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5571"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="41709" checksum="F122ABE496CC12AA" modified="2011-09-21" version="1">MSISRMVYTGTSYFGEYAREKIAEEVSKRHFRKALLISDKALEACGITGKIEEVLKKNGIPYTLFDEVKPNPAIENVRAGLACYKNSGSDFILAVGGGSVIDTAKAVAVTANNPENEDIVSLEGMDKSKNPAVPLIAVPTTAGTGSETTMDYVITNTQEKRKMACMDSKVVPAAAILDTEIMASLPLSLTAATAMDALTHAVESYLSKGAFSFSEMLSLKAVSLISENFIRVVKEPGNYEVRKELAIAQYLAGMSFTNVGLGIVHSMAHPLSAFYDIPHGTANALILPHVLEFNAAACPEKIRQLAAAFDPSFDTSKSAEEASAHCVEIIRSFLTASGLPQHLYELGVRESDFEALAQSACEDAATPDNPREADENTIKQLYQSMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH93</accession>
    <name>F7KH93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862366.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05232"/>
    <dbReference type="EnsemblBacteria" id="EGN33265">
        <property type="protein sequence ID" value="EGN33265"/>
        <property type="gene ID" value="HMPREF0994_05232"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5713"/>
    <dbReference type="eggNOG" id="ENOG5032W1K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2245044_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="102" mass="12168" checksum="8B8BE333170A8A04" modified="2011-09-21" version="1">MAWRKVIEACMEDVKHHFDDIQQAIEFGCYIQPDNYFVSYIFATDSQLETARQSGLTEQINSYHREQLIKSHYPIEGIKDCTFASQEECDREFGGNWYYYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHE4</accession>
    <name>F7KHE4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">MEP cytidylyltransferase</fullName>
            <shortName evidence="3">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispD</name>
        <name evidence="4" type="ORF">HMPREF0994_05273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255116.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05273"/>
    <dbReference type="EnsemblBacteria" id="EGN33008">
        <property type="protein sequence ID" value="EGN33008"/>
        <property type="gene ID" value="HMPREF0994_05273"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5758"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_2_2_9"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 3 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="3">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="238" mass="27082" checksum="C4C1CE9A69208F33" modified="2011-09-21" version="1">MQEKTAAVVLAAGKGKRMNSDVPKQFMLLREKPVLYYSLQTFQDSFVDEIILVTEKGEEEYCRKEIVDKYHLTKVKHITAGGTERYFSVANGLEAVSEDCAYIFIHDGARPFVTGQIINDALENVRVHKACVAAMPVKDTIKIADDQDFAVSTPRRDLVWMMQTPQVFQASLIREAYRRLIKEEEKLRTEGIQITDDAMAVETLLHQPVKLFRASYENIKITTPEDLVIADGILEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHR1</accession>
    <name>F7KHR1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255240.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05397"/>
    <dbReference type="EnsemblBacteria" id="EGN32838">
        <property type="protein sequence ID" value="EGN32838"/>
        <property type="gene ID" value="HMPREF0994_05397"/>
    </dbReference>
    <dbReference type="GeneID" id="29727752"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5900"/>
    <dbReference type="eggNOG" id="COG3394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064244_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="33107" checksum="74EA8764BE34CFFB" modified="2011-09-21" version="1">MNERFLIINADDFGLCKSMNQAICELFRLGAITSSSILSPAPMAMNACRYAKEGSFPVGVHWTLFSEWKEECWMPSDKEKRDSSLTVNGLLPADGGAAAKRAASGDVTRELEAQYRFMTDAGCTPDHADSHGGTLYGINGRLFFLNAFRLCQKYRLPFRFARSPAFLERQFGGKVSPALKAAHAAVCFLADRMKVSLPDDFITHPLPVEKIRDYEALCSYYEEQLAAAPAGISEVFLHPSVPDPVLSLRTPQWKKREWEYEFLKSGRLNRFLEKEGFRLVSWKSAPFPCKKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHZ0</accession>
    <name>F7KHZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05486"/>
    <dbReference type="EnsemblBacteria" id="EGN32927">
        <property type="protein sequence ID" value="EGN32927"/>
        <property type="gene ID" value="HMPREF0994_05486"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5998"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="117" mass="13609" checksum="380D4B6B7B6D157A" modified="2011-09-21" version="1">MNKKMRHIDFSFGASLRNAREKRNYRREQIAERAEISPRFLAAIESGRRKPSLDVLIRLVNAIGASFDEILAPQMITDSEIVDRIRRLVPQCSQRDQELLLALIDKMLDTKEKKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI03</accession>
    <name>F7KI03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571042.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05505"/>
    <dbReference type="EnsemblBacteria" id="EGN32946">
        <property type="protein sequence ID" value="EGN32946"/>
        <property type="gene ID" value="HMPREF0994_05505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6019"/>
    <dbReference type="eggNOG" id="ENOG50322KC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150560_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043753">
        <property type="entry name" value="DUF5699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18956">
        <property type="entry name" value="DUF5699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="103" mass="11168" checksum="46D2EF0DB0A3C535" modified="2011-09-21" version="1">MRALVFLLKLLLKILVAPVILALTLFVWICVGIVYISGLVLGLISMVIALLGVAVLITYSLQNGIILLVMAFLISPFGLPMAAIWLLGKVQDLKFAIQDLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIA1</accession>
    <name>F7KIA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255387.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05580"/>
    <dbReference type="EnsemblBacteria" id="EGN32405">
        <property type="protein sequence ID" value="EGN32405"/>
        <property type="gene ID" value="HMPREF0994_05580"/>
    </dbReference>
    <dbReference type="GeneID" id="29729037"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6096"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036301_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="405" mass="45288" checksum="EDD573DF0A1FEE5F" modified="2011-09-21" version="1">MNRAADSKLIHDSLYAPNGGHVPKEGGSCSILLKKRYTSVVFCPGEPFEGQRGPGSMYPRCICLEHNGEKNGTLLATMEYYTETTPVFPVYESTDDAHSWHYLSCVEDTQLGQGCRFQPHLFELPCDMGRIKEGTILCAGNIIPKDMSTTTLHMYKSEDVGKTWEFVSEIVKGERDEKHIMGLPVWEPFLLQSPDGRLFCYYSDERYKDHGNYNQLLAHKVSEDGGYTWGEEKIDVAFPDGNLRPGMPVVAYLPNGKFIMVYEMVNEDRIPVYFRISDSMDDWGEPDFIGNPIVAVDGSYLTGTPYVAWINKGGKDGTILAAGRGFSHIFANSEMGMGFWEKMDSLIPIDNNYNFTGYSQCILPIRGGRQILNLSPRQISDRQALIEAAVADVYVRASLSGAITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KID6</accession>
    <name>F7KID6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255422.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05615"/>
    <dbReference type="EnsemblBacteria" id="EGN32326">
        <property type="protein sequence ID" value="EGN32326"/>
        <property type="gene ID" value="HMPREF0994_05615"/>
    </dbReference>
    <dbReference type="GeneID" id="29728354"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6135"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357466" evidence="2">
        <location>
            <begin position="26"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="573" mass="63962" checksum="4562702C38B7CD37" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIL2</accession>
    <name>F7KIL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05691"/>
    <dbReference type="EnsemblBacteria" id="EGN32180">
        <property type="protein sequence ID" value="EGN32180"/>
        <property type="gene ID" value="HMPREF0994_05691"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6222"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="34370" checksum="5F6192E3243DA0E5" modified="2011-09-21" version="1">MNRKSSKYSLAKFRKEFPLHLMLFPGIILIIIFNYVPMAGLVIAFQKFIPSKGMFGNQEWIGLDNFTYVFSLPGFKQAMVNTVIIAAWKIVLGLLVPVVFALLLNEVRHIKFKKTIQTVVYLPYFLSWVVLGGIFIDLLSPGSGIVNGIINSLGGESIFFLGDNRYFKGTLIVTDIWKTFGYNAIVYLAAIVGVDTSLYEAAETDGANRLQQIWHITLPGIRGIVVLMMVLSLGNILNAGFDQVFNLYTKAVYESGDILDTFIYRLGLIDAQYGAATAVGLFKSIISTIFISTSYYLAYKFSNYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIR6</accession>
    <name>F7KIR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004607959.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05755"/>
    <dbReference type="EnsemblBacteria" id="EGN32244">
        <property type="protein sequence ID" value="EGN32244"/>
        <property type="gene ID" value="HMPREF0994_05755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6293"/>
    <dbReference type="eggNOG" id="ENOG5032RUS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199700_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="62" mass="6935" checksum="F257FE08B4C3CAEF" modified="2011-09-21" version="1">MTLFTDNPFEKMMIQRPGGRRDNAPPVPHSPACASCPYKGQLPCVGYCLKQVQEKKASEPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJJ7</accession>
    <name>F7KJJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255807.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06031"/>
    <dbReference type="EnsemblBacteria" id="EGN31385">
        <property type="protein sequence ID" value="EGN31385"/>
        <property type="gene ID" value="HMPREF0994_06031"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6602"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057834_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09024">
        <property type="entry name" value="Aldose_epim_lacX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037481">
        <property type="entry name" value="LacX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="291" mass="33178" checksum="45A2006C06EBE76A" modified="2011-09-21" version="1">MGDYELHNEEIAVRIALLGAELKSLKDIKSGREYMWSGDPAFWKRVSPVLFPLVGNYRNKQAVYEGKAYPLSQHGFARDREFALVSQTDEEAWFALESDETTRECYPFDFRLELGYRLSGREVEVLWRVKNTGKETMYFSIGGHPAFACPLNEEGNKEGYSFWFDSGEPLETRIIGPDGLATDDHEEYFLDEGTLPITEELFDQDALVVEGGQAHEVRLLDPSGGAFVTMQFDAPLFGLWSPPGKKAPFICIEPWYGRCDHKDFRGTIEEREWGNMLEEGGEFNASYHIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJZ4</accession>
    <name>F7KJZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Band_7_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255959.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06183"/>
    <dbReference type="EnsemblBacteria" id="EGN30676">
        <property type="protein sequence ID" value="EGN30676"/>
        <property type="gene ID" value="HMPREF0994_06183"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6771"/>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042784_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band_7_1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="452" mass="48522" checksum="9DB8E2101B66052A" modified="2011-09-21" version="1">MGLIRAAVQSAASVMADQWEEYFYCDSIPANILAVKGSKKTSRRGSNKKGSENVISNGSVIAVNEGQCMMIVDQGKVVDVCAQPGEYIYDASSEPSIFYGDLGENVRRSFETFGIRFAFGGEAPKDQRVYFFNTKEIVGNKYGTANPVPFRVVDRNIGLDIDIAIRCHGEYSYRMVDPICFYVNVCGNVEVAYSRENLDSQLKSELMTALQPAFARISDMGIRYSALPGHTDEIASALNTVLSEKWVKLRGIALASFGVSSVKASEEDEDMIKQLQKAAVLRDPNMAAATITGAQADAMKTAAGNKSTGPMMAFAGMNMAANAGGINAGQLFEMGQKNRQQEASAQPSPAGGQAYTPANTPAAGSWNCSCGAVGNTGKFCSECGKPRPAEEGWVCSCGAVNKGRFCSECGKPKPAGARLYKCDKCGWEPEDPAHPPKFCPECGDPFDESDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKA2</accession>
    <name>F7KKA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256051.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06281"/>
    <dbReference type="EnsemblBacteria" id="EGN30200">
        <property type="protein sequence ID" value="EGN30200"/>
        <property type="gene ID" value="HMPREF0994_06281"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6885"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="34579" checksum="D5F58D52A3FA0977" modified="2011-09-21" version="1">MKRKEKKPLKYYLKRDRFIYLLMLPGLLWYIIFCYLPMFGIIIAFEDYKPFWGIQGIFTSNWVGGKHFLKFFKSAYCFRLIKNTLLLSIYSLIWSFPLSIILALFINELKGKFFKKTVQTVSYLPHFLSAVIVCGMIRTLTSVDGGLVNAIVTAFGGEAIPFLGQPEWFRSIYTISEVWQSIGWESIVFIAAMMSIDKELYEAAMVDGAGVLRRMVSITIPGIMPVITIMLILRVGSILNLGYEKVLLLYSPQIYSTADIISTYVYREGVVNQNYSFAAAVNLFTSVISLILVLGTNKITKKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB3</accession>
    <name>F7KKB3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256062.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06292"/>
    <dbReference type="EnsemblBacteria" id="EGN30211">
        <property type="protein sequence ID" value="EGN30211"/>
        <property type="gene ID" value="HMPREF0994_06292"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6896"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="30949" checksum="F19FCD2D2B8EA555" modified="2011-09-21" version="1">MRRKKIRQDFWVSLILGIMSVIALFPFYMMFVMGTYYSEDLFHGLPLLISDYFLENLKTTLDNGLPATYLNSIIVSSVSVLVCLFTSITIGYALAKFRFRGQKVIMVLVLMGMMLPTQISIIGYIMEMRAAHLTNTLWSVICVWIANPFSAFFMMQFLQDSVPEEMLESARIDGCSEPRILSSIVVPCIKPAIMTVATLVFLWSWNNYLLPLITLNKQKVYTLPLMISNISVAYRQDYGAQMLALALSTFPVLLIFIMGSKYFVKGITAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKK3</accession>
    <name>F7KKK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">23S rRNA (-C5)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256144.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06382"/>
    <dbReference type="EnsemblBacteria" id="EGN47990">
        <property type="protein sequence ID" value="EGN47990"/>
        <property type="gene ID" value="HMPREF0994_06382"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6986"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051804_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="55"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN47990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="32461" checksum="6C749131E4794C24" modified="2011-09-21" version="1">MWKADNWKDYEVLDTGNGEKLERWGEYLLVRPDPQVIWDTPRKAPGWKKKNGHYHRSSKGGGEWEFFNLPEEWSIHYGELTFRLKPFSFKHTGLFPEQAVNWDWFSGIIRSSKRPLKVLNLFAYTGGATLSAAKAGANVTHVDASKGMVSWAKENAAASGLSDAPIRWLVDDCVKFVEREIRRGNTYDGIIMDPPSYGRGPKGEIWKIEESIFPFVKLCSQLLSKDARFFLINSYTTGLQPAVLSYMMQLTITPILGGRVEADEIGLPVAENGLILPCGASGRWSSGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKM4</accession>
    <name>F7KKM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06403"/>
    <dbReference type="EnsemblBacteria" id="EGN48011">
        <property type="protein sequence ID" value="EGN48011"/>
        <property type="gene ID" value="HMPREF0994_06403"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7009"/>
    <dbReference type="eggNOG" id="COG5337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022931_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="56389" checksum="D0E3B4AA27E1B7F3" modified="2011-09-21" version="1">MNSRKIYVGLVLLFLLAALMFSRHIDPEKKRSQQHLTYNTDVEDTSLSIEADSFSTHLPIVSIETGGQIIPGRPEEGQHVRSIVNTYIQADMKIYDAAGVLNTLSAEPDIDSQINIRVRGNSSRLFDKVGYLFQFTKDDGSDRDIAVMGMEKDSTWVLHGPFLDKTLIRNYMWYNLSGRIMDWAPDVRFCEVFLNQEYQGVYVMTEQISVGEGRIEVTKYDGKAGVSSYIVCADRESVNDVQYLQNFTSYARRIYGRLEVKYPGTSKLTPELTETISRDFSKFEKALYSYDYDSARYGYQNYIDVDSFVDYFIINEVAQNTDAGLYSTYFYKDVTGKLKMCVWDFNNCCDNYIEEQTPMAGFFMQSRPWYFMLCKDENFNKRIISRYRELRRGILSEEAITANIREIRDYLGTAVDRNFEKWGYSFLPENDLLSDDYRKIGSYEEAMEQYETRLIRHMRWMDEHIEDLLSYSHESKNKKFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL86</accession>
    <name>F7KL86_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46966.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06615"/>
    <dbReference type="EnsemblBacteria" id="EGN46966">
        <property type="protein sequence ID" value="EGN46966"/>
        <property type="gene ID" value="HMPREF0994_06615"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056705_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029465">
        <property type="entry name" value="ATPgrasp_TupA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14305">
        <property type="entry name" value="ATPgrasp_TupA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46966.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="35164" checksum="4056A2D64806F6A8" modified="2013-09-18" version="2">MLWKLKVLGIFNHMSDVKYLKLMYRIYIGKKLNLDQPQTFNEKLQWLKLHDRKPEYTSMVDKYEAKKYVAERIGEEYIIPTLGVWDNFEEIDFDSLPNQFVLKTTHDSGGVVICRDKISFDKKKAREKLEKSLKRNYYMQGREWPYKDVKPRIIAEQYMVDESGYELKDYKLFCFDGFAKAMFIASDRYKAGEETKFDFFDMDFKHLPFTNGHPNAEHEIKRPESFEKMKELAGKLSEGIPQVRVDFYDINGQIYFGELTLSHWGGMVPFEPEEWDYKFGEWIKLPDSIEGVSDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLB9</accession>
    <name>F7KLB9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256401.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06648"/>
    <dbReference type="EnsemblBacteria" id="EGN46572">
        <property type="protein sequence ID" value="EGN46572"/>
        <property type="gene ID" value="HMPREF0994_06648"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7270"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051820_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="271" mass="30625" checksum="C1F2016210DBA42D" modified="2011-09-21" version="1">MQNCFQSTGTYIADQSLTDSVNIAAALERPLLIKGEPGTGKTMLAQAVAEALGMELITWNIKSTTKAQDGLYTYDTIKRLYDSQFGEKGVNDISRYIRLGRLGEAFTRDSRTVLLIDEIDKADLEFPNDLLWELDRMEFHIPETGVTIRAKERPIVIITSNAEKELPDAFLRRCIFHYIDFPDKAMLTQIVKVHFPLVEAHLLEAAVSAFEEIRSIRSLRKKPGTSELIDWVNALSLSGISPEILAKELPFPGILIKKDEDMDAVKKHRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLH0</accession>
    <name>F7KLH0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0210 protein HMPREF0994_06706</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0210 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256459.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06706"/>
    <dbReference type="EnsemblBacteria" id="EGN46630">
        <property type="protein sequence ID" value="EGN46630"/>
        <property type="gene ID" value="HMPREF0994_06706"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7335"/>
    <dbReference type="eggNOG" id="COG2848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048704_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08025">
        <property type="entry name" value="RNR_PFL_like_DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01221">
        <property type="entry name" value="UPF0210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="454" mass="47779" checksum="D6766144794A59E7" modified="2011-09-21" version="1">MINIFEVNETNKMIEKENLDVRTITLGISLLDCIDSDLDRVNEKIYQKITRAASNLVQVGEEISREYGIPIVNKRISVTPIALIGGAACKTPEDFAVIADTLDKAAKEVGVNFIGGYSALVSKGMTPAEELLIRSIPMALARTERVCSSVNLGSTKTGINMDAVRLMGEIILEAAEYTKETDSSGCTKLVVFCNAPDDNPFMAGAFHGVTEADQIINVGVSGPGVVKTALEKVRGENFEVLCETIKKTAFKVTRVGQLVAREASRRLGIPFGIVDLSLAPTPAIGDSVADILCEIGLEHAGAPGTTAALALLNDQVKKGGVMASSYVGGLSGAFIPVSEDQGMIDAVMAGALTLEKLEAMTCVCSVGLDMIAIPGDTKASTISGIIADEMAIGMVNQKTTAVRLIPVIGKKVGDHAEFGGLLGHAPIMPVNSFGCEAFVNRGGRIPAPIHSFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLK6</accession>
    <name>F7KLK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256497.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06744"/>
    <dbReference type="EnsemblBacteria" id="EGN46668">
        <property type="protein sequence ID" value="EGN46668"/>
        <property type="gene ID" value="HMPREF0994_06744"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7371"/>
    <dbReference type="eggNOG" id="COG4289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028269_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="PTHR35339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="589" mass="67003" checksum="6D7319A141191BB3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS77</accession>
    <name>S2KS77_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_07197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07197"/>
    <dbReference type="EnsemblBacteria" id="EPC05142">
        <property type="protein sequence ID" value="EPC05142"/>
        <property type="gene ID" value="HMPREF0994_07197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="578" mass="66289" checksum="D396094BC502AAA8" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS87</accession>
    <name>S2KS87_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360153.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07207"/>
    <dbReference type="EnsemblBacteria" id="EPC05152">
        <property type="protein sequence ID" value="EPC05152"/>
        <property type="gene ID" value="HMPREF0994_07207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028398_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03487">
        <property type="entry name" value="RT_Bac_retron_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="327" mass="37464" checksum="C7C00E6CF71F741F" modified="2013-09-18" version="1">MGNSPLWKYCTREQCQDFILSLRLIPGGEKMSREKQLSCLYTLSNRGSRNYRRVTIDKKDGGSRTLLVPCGLLKGVQRNILHHVLDERPVSPCARAYRKGTDIRGNASCHLGKRLVLKLDISHFFDSILFPRVYSAAFPETLFPPAAAMLLTSLCCCNERLPQGSPASPAISNLVMRPFDIYMDGWCRERGIAYTRYCDDMTFSGDFDAAALCSKVRSYLEAMGFTLNEKKTKLLTGDVRQSVTGIVVNDKLQVSREYRKKLRQEVYYCKKYGIDAHLERVEADTGIRWEKELYICSVQGRLHFVLQVNPQDDEFAGYCREWKELFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS95</accession>
    <name>S2KS95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar (Glycoside-Pentoside-Hexuronide) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06997"/>
    <dbReference type="EnsemblBacteria" id="EPC05329">
        <property type="protein sequence ID" value="EPC05329"/>
        <property type="gene ID" value="HMPREF0994_06997"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="461" mass="51067" checksum="2C319A284A153F1A" modified="2013-09-18" version="1">MKQNRNRNKYTFGLGTIGRDMVYSMVSMYLIYYLTDIIELPTSTLWWITVIVLCARIFDALNDPIMGVIVDNTKTRFGKFKPWIALGALVSGMLTVLLFTDFGLQGAGYIAVFALIYIAWGLAYTANDISYWSMLPSLSLEQKEREQIGAVARICANVGLFFVVAGIVPITSVFGNALGSMQKGYFAFSLLVVGIMWAGQCITLVGVKEPRNLVAQNKHTSLKELLKVIFGNDQLLYTAVSMALFMIGYTTTTSFGLYFFKYAYGDEGMYSIFALILGVSQIAALVVFPLISRHFERRTLYAFSTGLVVAGYVIFFFAPLDTMLFIGIAGVLLFIGQAFIQLMMLMFLADTVEYGFWKSGRRNDSVTFSIQPFINKMGGAVASGVVSATVIVSGIKDAQSAEQVTAGGLLMMKMAMMIFPLLCILAGFLLYLKKYKIDSSLYARILKELRERGDIRTGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSB3</accession>
    <name>S2KSB3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ORF">HMPREF0994_07178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360094.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07178"/>
    <dbReference type="EnsemblBacteria" id="EPC05182">
        <property type="protein sequence ID" value="EPC05182"/>
        <property type="gene ID" value="HMPREF0994_07178"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EPC05182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="218" mass="24129" checksum="A3DAD926B15E3E98" modified="2013-09-18" version="1">MGQKVNPHGLRVGVIKDWDSRWYADAEFSDFLVEDYNIRKYLKKKLYSAGVSKIEIERASDRVKVIIYTAKPGVVIGKGGAEIEVTKKELSKLTDKKVLVDIKEIKRPDKDAQLVAENIAGQLENRVSFRRAMKSCMGRTMKAGAMGIKAACAGRLGGADMARTEFYSEGTIPLQTLRADIDYGFAEANTTYGKVGVKVWIYKGEILPAKGNKEGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSU1</accession>
    <name>S2KSU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06985"/>
    <dbReference type="EnsemblBacteria" id="EPC05317">
        <property type="protein sequence ID" value="EPC05317"/>
        <property type="gene ID" value="HMPREF0994_06985"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1968332_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="130" mass="14876" checksum="8B9295A6DBE7B42B" modified="2013-09-18" version="1">MADKENSKNRIITIPNLLSFFRICLIPLIVWLYCKKQAYFWTGAILILSGLTDLVDGYIARTFNAVSDLGKILDPVADKLTQAVMLLCLLTRFPFMLFPLVLLILKELFMAITGLWIIRNLQALKRDNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWK9</accession>
    <name>S2KWK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07063"/>
    <dbReference type="EnsemblBacteria" id="EPC05395">
        <property type="protein sequence ID" value="EPC05395"/>
        <property type="gene ID" value="HMPREF0994_07063"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1872781_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="14791" checksum="B33BE6376958A451" modified="2013-09-18" version="1">MNSVGGGSRRLPVRRTAFPCRRLSYCLPQWSMCCPLQPQKRGVSKGFVLPEGGQRGKTPHLCGFGRMGSSDRPLRAAVFRQNKPLRNITVFSHGEGNTYSTAAGSKKDGGRERRRGGRGGGGNRQVMVKCGGKDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>S2LK53</accession>
    <name>S2LK53_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_06986</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359756.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06986"/>
    <dbReference type="EnsemblBacteria" id="EPC05318">
        <property type="protein sequence ID" value="EPC05318"/>
        <property type="gene ID" value="HMPREF0994_06986"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EPC05318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="710" mass="80755" checksum="1B8D8EE5E83F9854" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2D9</accession>
    <name>F7K2D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249967.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00018"/>
    <dbReference type="EnsemblBacteria" id="EGN48251">
        <property type="protein sequence ID" value="EGN48251"/>
        <property type="gene ID" value="HMPREF0994_00018"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.20"/>
    <dbReference type="eggNOG" id="COG4725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018702_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090304">
        <property type="term" value="P:nucleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="184" mass="21208" checksum="773C7FE6058D8337" modified="2011-09-21" version="1">MAEAKKYGIVYADPPWRYDMKRGKGVAENHYPTMSMDEICALPVADLAAKDSALFLWATFPQLNEAFRVIEAWGFHYKTLAFLWLKQNRKADSWFYGMGFWTRSNAEVCLLATRGHPKRQCAGIHQFVISHIEQHSKKPDEVRDKIIKLMGDQPRVELFARQQTPGWDVWGNEVDCSITMPQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2H7</accession>
    <name>F7K2H7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250005.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00056"/>
    <dbReference type="EnsemblBacteria" id="EGN48289">
        <property type="protein sequence ID" value="EGN48289"/>
        <property type="gene ID" value="HMPREF0994_00056"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.60"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="513" mass="58968" checksum="2AABDB6D007C0ACF" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2M4</accession>
    <name>F7K2M4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN42720">
        <property type="protein sequence ID" value="EGN42720"/>
        <property type="gene ID" value="HMPREF0994_00103"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3026487_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="55" mass="6517" checksum="0D442A32F4672EFC" modified="2011-09-21" version="1">MKEVNVGVSHTTPLKFEPDKSAEEWMNGIEKRLEYEMEYYGHYHTDKKINKGDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V2</accession>
    <name>F7K2V2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methanosarcina family methyltransferase cognate corrinoid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250130.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00181"/>
    <dbReference type="EnsemblBacteria" id="EGN40738">
        <property type="protein sequence ID" value="EGN40738"/>
        <property type="gene ID" value="HMPREF0994_00181"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.193"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082102_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="212" mass="22556" checksum="7415454FA7AB9D34" modified="2011-09-21" version="1">MVEITEISAMLQKGKAKIVKELVQQALDEGQDPKEILNDGLLSGMMIVGTKFKNNEVFVPEVLVAARAMNAGLGILEPKLVEVGNEPVGKAVIGTVKGDLHDIGKNLVAMMLKGAGFEVIDAGVDVDAETFISKAEEVHADVICMSALLTTTMPNMQECIDKLKEKGLRDKYIVMVGGAPVNDSFAKKIGADYYTPDAATAAEVARNAVTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K303</accession>
    <name>F7K303_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YlmH_RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250181.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00232"/>
    <dbReference type="EnsemblBacteria" id="EGN37871">
        <property type="protein sequence ID" value="EGN37871"/>
        <property type="gene ID" value="HMPREF0994_00232"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.252"/>
    <dbReference type="eggNOG" id="COG2302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075687_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040591">
        <property type="entry name" value="YlmH_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17774">
        <property type="entry name" value="YlmH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlmH_RBD" evidence="1">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="256" mass="29142" checksum="FB84D9352F715ACA" modified="2011-09-21" version="1">MSAETDKDLLQLKKRFLELAEKSYAQNIYTFTGFLSMAEQEALFEAMQKNKSYTFSLSGGGEGCERQMARFGSPEELGYEEPFPVEVLKISPLLEKFADNFTHRDFLGAVMNLGIDRSTVGDFFLEGKSAWLYCTQRIAPYICENLNKVRHTNVRCEIVEQGMELPVREPEKISLIVSSERADAVLAKLWQLSRNQSLELFRTKKVYVNGRLCENNSCQLKSGDRVSTRGYGRFLYYGALGETRKGRLNVSAGVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K336</accession>
    <name>F7K336_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250214.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN37904">
        <property type="protein sequence ID" value="EGN37904"/>
        <property type="gene ID" value="HMPREF0994_00265"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1946020_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="129" mass="14986" checksum="B5A12A53185B226E" modified="2011-09-21" version="1">MKVNNNILPQKNTIQDAAVHLYKDHNNVYYMCKISLGHSFINCIVLEEDKVIEIVDIQCETINDGIGSLMMEKLISYASENNYCKIVGWLSIVDEEHIDRLRHFYIKHGFTIKTEYDGMKLADIELFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3D8</accession>
    <name>F7K3D8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250320.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00371"/>
    <dbReference type="EnsemblBacteria" id="EGN33512">
        <property type="protein sequence ID" value="EGN33512"/>
        <property type="gene ID" value="HMPREF0994_00371"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.401"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_30_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="144" mass="16729" checksum="9C43F6F0CB8D44B5" modified="2011-09-21" version="1">MKQESKKVFGLMNQQFKELTAIYHRAACQYGISDNEFWVLYALFVFEEEQSQQSISEMWSLPKQTVNSVVSGMIKKGHVYLETIPGTRNKKVIRLTEEGKRFGESVIFPIYDAEQRAVDNMTSQEQQLCTELLAKYISFLDKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3E1</accession>
    <name>F7K3E1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250323.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00374"/>
    <dbReference type="EnsemblBacteria" id="EGN33515">
        <property type="protein sequence ID" value="EGN33515"/>
        <property type="gene ID" value="HMPREF0994_00374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="34484" checksum="CFD28D0D25F00511" modified="2011-09-21" version="1">MSESVLTMNQVEKRYRNVPVLQDITMEIPRGSIYGLVGSNGAGKSTLMRLISGQTRIDRGEMRLFGKIPEKKEQRVRRRIGTLIEEPGFYGDLSARQNLEYYRLQFGIPEKETISRLLDMVGLGNTGKKKYRNFSMGMKQRLGLALAMLAAPEFLVLDEPINGLDPEGILEIRNILLRLNQENGITLLISSHILSELENLATQYGFLSHGKMLEQISAKELKDKCGTYIILEVDDAGQMAVILEKELGITEYKILPDGHFNIYAPPERKEEISRAAILHGIGLHAISALNIELEDYYMNLMGGNADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3M4</accession>
    <name>F7K3M4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00453"/>
    <dbReference type="EnsemblBacteria" id="EGN31968">
        <property type="protein sequence ID" value="EGN31968"/>
        <property type="gene ID" value="HMPREF0994_00453"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="33696" checksum="F8FB87318B8A8A59" modified="2011-09-21" version="1">MKPSLAFPIPHTPEFDVNRIKNISEKYLDISYASEKEHVLDLYLPEKKKEEYPLIIYIHEGAFIFGSKRDKRMESLFTALQEGYAIASVDYRKADQVTWPAPIYDIKAAIRFLRAHAGEYKLDKKRFTVWGMSAGAYLGVMTAVTNHMQWFEDSSMGNPHESSEIQSVVDLCGACAGFHRLDDFIEENGFGIANHNEANSPESILMGQPLKDARELCNMANPINYIREDIPPFFVLHCLKDPVVPVQQSRLLVEEIVKKAGADKVTAIFTESEADHGKPDYDTRSIVDAALEFLNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3M6</accession>
    <name>F7K3M6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250404.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00455"/>
    <dbReference type="EnsemblBacteria" id="EGN31970">
        <property type="protein sequence ID" value="EGN31970"/>
        <property type="gene ID" value="HMPREF0994_00455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.499"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068890_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="173" mass="19437" checksum="0F981738A4D718A7" modified="2011-09-21" version="1">MTELIAFFSRGDENYVDGEIKTLETGNTEVVAGVIQKLTGAELFKIEPLKEYSKDYNECIAQAQSDQMQNVRPELKAYPESIEPYEAIYLGFPNYWGTMPMAVFTFLEHFDFTGKIIRPFCTHEGSGMADCLNDLINLCPDAKVEEGLVINGSRVYKSVKEIEDWVAAVGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3T3</accession>
    <name>F7K3T3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00512"/>
    <dbReference type="EnsemblBacteria" id="EGN45516">
        <property type="protein sequence ID" value="EGN45516"/>
        <property type="gene ID" value="HMPREF0994_00512"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1223432_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN45516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="24802" checksum="3A6F583A16CDCF85" modified="2011-09-21" version="1">MGILTGFLCLLCFCLLGVKGITRKFGLSAADNFFMKLHKPLSAALLIIGLIHLICALSLIKTRHISVYLSGAAILFTLVLLITLCHICRDDRIRLKQHRLLTCIMLLCIVLHIVSYSIDYGNYRSAIADIHLSGTDFSRMPDGNYEGEYDAGYIYAKVQVTLRNGRITHIDLLSHDNERGKAAEQVLDVITDTQTLPVDAVSGATCSSLVIQKAVENALTGGISHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3X9</accession>
    <name>F7K3X9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250507.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00558"/>
    <dbReference type="EnsemblBacteria" id="EGN44746">
        <property type="protein sequence ID" value="EGN44746"/>
        <property type="gene ID" value="HMPREF0994_00558"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.606"/>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_2_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="4">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="5">
        <location>
            <begin position="490"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN44746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="569" mass="59438" checksum="84724196EAB4447D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K465</accession>
    <name>F7K465_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250605.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00656"/>
    <dbReference type="EnsemblBacteria" id="EGN44844">
        <property type="protein sequence ID" value="EGN44844"/>
        <property type="gene ID" value="HMPREF0994_00656"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.712"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="153"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN44844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="29059" checksum="4BEE0290FC3BC7FA" modified="2011-09-21" version="1">MYNLLVVDDESIIRRGIRELVDFESLGIGGCFEAEDGEKALAVMKEHPIDLILADINMPGMSGLEFCRRAKELDAGVKIAILTGYDYLDYAIRAIKIGVDDYALKPLSKDDIQKLLSRLAEKKRETDSFTAVRQAVDNLAMEAGSDGKGSLRGQISEALEKHLSDTGFSLSMLAEELGYSVSYLSTLFKKYFGGNFRDYLLDVRLERAKILLLSTEMKNYEVAAAVGIEDPNYFSVCFRRKYKTTPREFRTEAGRGKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K492</accession>
    <name>F7K492_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FlgM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250534.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00585"/>
    <dbReference type="EnsemblBacteria" id="EGN44773">
        <property type="protein sequence ID" value="EGN44773"/>
        <property type="gene ID" value="HMPREF0994_00585"/>
    </dbReference>
    <dbReference type="GeneID" id="29723660"/>
    <dbReference type="eggNOG" id="ENOG5033Y1F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2233054_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlgM" evidence="2">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="105" mass="12099" checksum="43FDE6E6383B2618" modified="2011-09-21" version="1">MKISMEHIHNMYRQNEAQSVKKDENEYGINRKRNFDEIKISAQTEMIPGETEFAKILAEKLSAEVRQEAPAEKLDILREKIRTGCYEIDVSAIASRILLEDKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4C6</accession>
    <name>F7K4C6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250654.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00705"/>
    <dbReference type="EnsemblBacteria" id="EGN44054">
        <property type="protein sequence ID" value="EGN44054"/>
        <property type="gene ID" value="HMPREF0994_00705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.764"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028877_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041063">
        <property type="entry name" value="Glyco_H_20C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="PTHR21040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18088">
        <property type="entry name" value="Glyco_H_20C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="140"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_H_20C_C" evidence="6">
        <location>
            <begin position="419"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="623" mass="72411" checksum="BE27F02809002F33" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4M3</accession>
    <name>F7K4M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43515.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00806"/>
    <dbReference type="EnsemblBacteria" id="EGN43515">
        <property type="protein sequence ID" value="EGN43515"/>
        <property type="gene ID" value="HMPREF0994_00806"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030GAE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021114_8_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43515.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="13017" checksum="DCCA7D6A0F5FBE48" modified="2013-09-18" version="2">METISFFDYKEDYYHGFLAGLLKMMDGYILKSNRESGLGRSDLLLLSPAYEGVAVIMELKIADSFAQLNDSARQALCQIKEKKYDAELKLEGYHTFIYYGISFYKKLCRVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4P6</accession>
    <name>F7K4P6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00813"/>
    <dbReference type="EnsemblBacteria" id="EGN43522">
        <property type="protein sequence ID" value="EGN43522"/>
        <property type="gene ID" value="HMPREF0994_00813"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.887"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="259"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="502" mass="55707" checksum="9E5F615F0A403763" modified="2011-09-21" version="1">MEGEKVGEVILTMKDIDKSFPGVHALKKVNLEVRRGEVHALMGENGAGKSTLMKILTGIYFKDSGQIIYEGREVAFTNPREAQDAGIAIVHQELNMMQQLTVAQNIFIGREYMKGKIIDDGRMNEEAGKLFEKLNIEIDPSQVMGDLTVGKQQMCEIAKAISRDVKVLVFDEPTAALTDSEINELFKIIRDLRSRNIGIIYISHRMDEIKIITDRVTVMRDGEYVGTLISKDCTKDDIINMMVGRTIYEDPKTESSVPSDAPVVLKVEHLQAGKMVQDISFELKKGEILGFSGLMGAGRTETARAIFGADRKESGDIYVNGRKVEIHSPQDAVEAGIGYLSEDRKRYGVVLDKTIAENTTMASLEKFVKGIFINRKSEEATAQDYVERLNTKTPTVNTPTLSLSGGNQQKVVIAKWLVRDCDILIFDEPTRGIDVGAKSEIYHLMNELAASGKSIIMISSELPEILRMSDRIMVMCEGKKTAEIPIEEASQEVIMQAATVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4U4</accession>
    <name>F7K4U4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pectate_lyase22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250822.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00873"/>
    <dbReference type="EnsemblBacteria" id="EGN43182">
        <property type="protein sequence ID" value="EGN43182"/>
        <property type="gene ID" value="HMPREF0994_00873"/>
    </dbReference>
    <dbReference type="GeneID" id="29724207"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.951"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057268_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047487">
        <property type="term" value="F:oligogalacturonide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027946">
        <property type="entry name" value="Ogl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14583">
        <property type="entry name" value="Pectate_lyase22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectate_lyase22" evidence="1">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="394" mass="45694" checksum="477B628D5A5B7C3B" modified="2011-09-21" version="1">MAAGRIIRNNFKEFTDELTGTKVTRLTEPDHVSHHMYFYNRMTTADGSRLLYCAELEGERQLYLMDLHTGDAVQLTEGDGLEDYGGLISAEDTHIFYQQKDGIWKLCLETLEKECVYRIPEGWNGGNWGMSQDNRFMAIVETLKSSLPERKKGDNWDFFALTCKAKPHCRIVYVDLQTGSSHTVLEDDCWFGHAQIRPGDPDTIMFCHEGPYDLIDARLWLVQSDGSNYRCCREQPSDLILTHEFWLPDGSKLAFVYRETTGSKEENIRMINPDTMEEEIFMPCSPYAHFICDKRNRYMVGDSQGSDVPIHLLKETDEEENGEIKNDFIYLVDVEKREERKLCYHGTSWKAVHGNPQDSHPHPCFTEDNRYVIFVSDKEGKPCIYRVDLEQFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K592</accession>
    <name>F7K592_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250970.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01021"/>
    <dbReference type="EnsemblBacteria" id="EGN42994">
        <property type="protein sequence ID" value="EGN42994"/>
        <property type="gene ID" value="HMPREF0994_01021"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1117"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="230"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="329" mass="37963" checksum="0F3B461684E9374F" modified="2011-09-21" version="1">MFDQIFFTQVQFPTPVTPVEVERQMSRNAQNLQEKENGTQEELPANMRNADYFIFGKMDTFSRPPVTDFALENLFYMEAFSIFTCPKGFFTNRKDYQSFLIIYTYEGNGGLEYMGKSYSLGPGDGFFIDCRVPHLYRTVGDVWKHGVFHLNGPLVPALFSRYMENGSVSFYQPFTGNYQKKLEELLSIYGSVQPCRDWLASDCISSILTDLLRNASEEKETDSPVPENLRYLIAYMEKHFTQALTLDFLSRFSGISKYYLSREFKKYTGYSPNDYLISLRVEHAKFLLRSTTLPANKIALTAGFHDINNFTNLFRKKTAMTPGGYRKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5A7</accession>
    <name>F7K5A7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transporter A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250985.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01036"/>
    <dbReference type="EnsemblBacteria" id="EGN43009">
        <property type="protein sequence ID" value="EGN43009"/>
        <property type="gene ID" value="HMPREF0994_01036"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1133"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_12_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="73" mass="8048" checksum="D5CAD2D90D0363F2" modified="2011-09-21" version="1">MRTLKEIPCGETVKVAKLTGEGAVKRRIMDMGITKGIDVFVRKVAPLGDPVEVTVRGYELSLRKADAEMIMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5A8</accession>
    <name>F7K5A8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transporter A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01037"/>
    <dbReference type="EnsemblBacteria" id="EGN43010">
        <property type="protein sequence ID" value="EGN43010"/>
        <property type="gene ID" value="HMPREF0994_01037"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1135"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="71" mass="7567" checksum="9730400B9058269E" modified="2011-09-21" version="1">MPLTMVNAGEPNVIRKVGGKEETRRFLENLGFVAGGVVTVVSEMNGSMIVNVKDSRVAIGKDMANKIMVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5D8</accession>
    <name>F7K5D8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha,alpha-phosphotrehalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251016.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01067"/>
    <dbReference type="EnsemblBacteria" id="EGN43040">
        <property type="protein sequence ID" value="EGN43040"/>
        <property type="gene ID" value="HMPREF0994_01067"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1168"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008788">
        <property type="term" value="F:alpha,alpha-phosphotrehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012769">
        <property type="entry name" value="Trehalose_TreC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02403">
        <property type="entry name" value="trehalose_treC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="11"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="548" mass="63643" checksum="538B5F8DD3647068" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5M5</accession>
    <name>F7K5M5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251110.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01161"/>
    <dbReference type="EnsemblBacteria" id="EGN42923">
        <property type="protein sequence ID" value="EGN42923"/>
        <property type="gene ID" value="HMPREF0994_01161"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1271"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="38403" checksum="2B8E0BB6D98692D2" modified="2011-09-21" version="1">MKLIIQIPCYNEAETLEVALNDLPKKLDGVDTIEYLIINDGSHDDTVEVARKWGVHHVVNFKQNKGLAKGFMAGLDGCLKCGADIIVNTDADNQYCGEDIAVLIKPILDGEADMVIGERPIDDTEHFSFVKKKLQHFGSWVVRKASHTNIPDAPSGFRAFSREAAMRMNVVNDYTYTLETIVQAGREKIAVTSVPVRTNAELRPSRLFKSIWGYVKKSVLTILRAYMMYKPLMCFTLLSIPSVLIGLGIGVRFLYFLANGTGGGHIQSLILACTLIIIGFLTFMIGLVADVIAANRKILQDVQYHVKRMEYDREAPVKEDKKKDGTKDILYFKPERDEEAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5S2</accession>
    <name>F7K5S2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01201"/>
    <dbReference type="EnsemblBacteria" id="EGN42602">
        <property type="protein sequence ID" value="EGN42602"/>
        <property type="gene ID" value="HMPREF0994_01201"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1314"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="235" mass="26805" checksum="E24493F9700497BD" modified="2011-09-21" version="1">MGENGDKKGMAVKDYEKTESYMLSCMNDSAHDKEHVYRVLYYALEIAKQEPDVDYEILITSCLLHDIGRKEQFENPGLCHARVGGDKAYAFLVGAGWTQERALRVKQAVAAHRYRSDNPPESIEAKILFDADKLDVTGAVGIARTLLYKGKMGQPLYTLQSDGSVSDGTDDEEESFFREYRRKLEKLYSRFFTKRGEELAKERREAAAAFYRDMLEEVRTAYQGKELLKDVLGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K757</accession>
    <name>F7K757_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251599.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01686"/>
    <dbReference type="EnsemblBacteria" id="EGN41724">
        <property type="protein sequence ID" value="EGN41724"/>
        <property type="gene ID" value="HMPREF0994_01686"/>
    </dbReference>
    <dbReference type="GeneID" id="29723695"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1841"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058772_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="1">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="34941" checksum="6B8418C726EE4752" modified="2011-09-21" version="1">MGVDPGLKIGEKVNLQKIREIFQCGSMGGMLPVNRTNVMVIIADHTLDFYHDKWKDGILYYTGTGKIGDQQLDGNPGYKNGKLYHSKTNGMQLHLFEILKKREYIYRGIVVLADQPYQEEQLDENGVKRKVWIFPLKLVEEELKLDLLDDQTIMTSLASVQDKDLPFHFSYNGKPKDKGKPVVIDKIEIYKRDRKISLNALAYARFECEIDRTHESFIRKNSNTNYTEPHHLVPMAFQNNFSVSLDVEENIVSLCSNCHNLLHYGRDYLFLLKRLYESRKNLLKKVGIDITFERLIQMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7E5</accession>
    <name>F7K7E5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01774"/>
    <dbReference type="EnsemblBacteria" id="EGN41587">
        <property type="protein sequence ID" value="EGN41587"/>
        <property type="gene ID" value="HMPREF0994_01774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="31849" checksum="64E66A6AD5795F24" modified="2011-09-21" version="1">MKNKKRSFKPAWFLVYIVMIVYAVICLYPVIWMGFYSLKNNEEIFVTNPFGPPIVPQWSNYVKAVTQFDIPLYFRNSIVVSLAAMFFGILFCLTFTYVVARVRVRTTKALHSLVMAGMFIPIQAVMTPLVVMVKNLHLTNTLWSLIIPYTALSFPFGVMVLYGFYLTLPMELEESAYMEGAGFMRTYFSIILPQMKSAISVLVIYQFMSHWNEFSLALILITKNELKTLPLGLAGFYGQFSTDWGPVGASLVIASFPVIILYIFFSNKVSDAMAYSGMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7I8</accession>
    <name>F7K7I8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251730.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01817"/>
    <dbReference type="EnsemblBacteria" id="EGN41630">
        <property type="protein sequence ID" value="EGN41630"/>
        <property type="gene ID" value="HMPREF0994_01817"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1987"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996931_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="28743" checksum="BE7F7DED10BEC3D7" modified="2011-09-21" version="1">MKDYIQQNKESWEFNVYDFWVKNAGTPEERAAKDIEAPIKMLKKYAAYFDSYEGVRVANICGSCGKKAIPLALLGAKVTVFDISSENRQYAMETAAAAHTSIDFVVGDVLEIDMDRYGGQFDVVFMEGGILHYFHDIREFMDVMYSLLRPGGRMICSDFHPFQKIADILEFQQPVTSYFSTDIIKGEMAHARFYPDEIRRQIPLCEYRKYTISEIINAVIESGFTLKRFDEHSAWTNPGLPGEFTVIAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7J7</accession>
    <name>F7K7J7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01826"/>
    <dbReference type="EnsemblBacteria" id="EGN41639">
        <property type="protein sequence ID" value="EGN41639"/>
        <property type="gene ID" value="HMPREF0994_01826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078717_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="211" mass="23776" checksum="41EF3EA8BFA98A9A" modified="2011-09-21" version="1">MEEITYREICPNDYRSIKKLIDEVWNLNQFCDTEKQLDDSLNIYLQSSLLNISYGKAAVQNGDVVGVLLGKDDGRQNIVRRSTAIWALAKSSVSLLLHSTKRMRRQLKGVLKISKADQKMMAVQKGDFTGHIELLIVGKNIQGAGVGKTLVRDFLSYAAQNGKCAIYVHTDTQCNYGFYDSQGFEQLDSIDVTLMDGRQMTLFLYQYTPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7K6</accession>
    <name>F7K7K6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251748.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01835"/>
    <dbReference type="EnsemblBacteria" id="EGN41648">
        <property type="protein sequence ID" value="EGN41648"/>
        <property type="gene ID" value="HMPREF0994_01835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="29077" checksum="F30B9298AE2AA5D5" modified="2011-09-21" version="1">MFMEERQKDIVRRLNETGRIIVSEIQEIYGVSADCARRDLRELERKGLLRRTHGGALPAEPKGIYPEKTYTPKDLPEVRKNYLIVAKKALEYIGQQEVVYITTSSVGYYMALNIPDSLQVTVLTNSVTIADVLRKKECCKVIFLGGEMSSRGHCHDYYTVRMVKNIRIDKAFLSHTAFSLDFGASIHDCAGVEFGKAVMESSTMNIGVYPSEKIGKTSIHSVCKASDYDLLITDAGVSQDFLIQAEEMGLACDVADEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7N6</accession>
    <name>F7K7N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyphosphate:AMP phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251843.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01930"/>
    <dbReference type="EnsemblBacteria" id="EGN41335">
        <property type="protein sequence ID" value="EGN41335"/>
        <property type="gene ID" value="HMPREF0994_01930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2119"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033786_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043751">
        <property type="term" value="F:polyphosphate:AMP phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022489">
        <property type="entry name" value="PolyP_AMP_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03708">
        <property type="entry name" value="poly_P_AMP_trns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PPK2" evidence="2">
        <location>
            <begin position="266"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="490" mass="57941" checksum="0937BEC322D09620" modified="2011-09-21" version="1">MLKNHVEQEKPQEEELLRRLEDARNHLFALQMQIKERALPVLVLMEGWGAAGKGSTIGKIIRNIDPRFFKVATMSAPTEEELRKPFLYRYFARLPEAGKFTFLDSGWMEEITGDVLRGKLDEKGYASRIDSVKRFERQLTDNGYLVMKFFFNIEEKEQKKRLDGLLSNEDTRWRVSESDRWQSKHYDKCLKVFDQYLNDTNASTAPWYIVDAHSRKWAQLQVLETLCQGIEVALQNKSLAVPLLQNTFPLEKMPRLDEIPLDKTMEEAEYQEELDKLQKRLGELHNRLYRKRVPLIIAYEGWDAAGKGGNIKRITGALDPRGFEVHPIASPEPHEKARHYLWRFWTRLPKTGHIAIFDRTWYGRVMVERIEGFCSTNDWQRAYNEINEFEKELVDWGAVVIKFWVHIDKETQLERFNERQNTPEKQWKITDEDWRNREKWDAYEAAVNEMIQKTSTTYAPWHILESVDKKYARIKALKIVIKELEKVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7S0</accession>
    <name>F7K7S0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar (Glycoside-Pentoside-Hexuronide) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251878.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01965"/>
    <dbReference type="EnsemblBacteria" id="EGN41370">
        <property type="protein sequence ID" value="EGN41370"/>
        <property type="gene ID" value="HMPREF0994_01965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2159"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="455" mass="49316" checksum="A5E61FCF326F34FB" modified="2011-09-21" version="1">MQEKKYLKWYNKVGYGSGDLAANMVYALLTSFVMIYLTDTVGLNAGIAGTLMMLSKFADGITDVFFGSLIDKTKSKMGKARPWMLWSYLGNAVMLVAIFAIPKSLGDTAKYAYFFIAYTLLNAVFYTANNIAYASLTSLITRNNNERVQVGSIRFMFSLATNLIVASVTVGLVGKLGGGAMGWRNVAIIYALIGLIVNTISVFSVKEVVEEDEGAVKKEEEEKLTLLESAKLLVKNKYYLMIVAVYILTYIQTGIAGIGIYYMTYVFGNPALLGTFSAAQMFPMIVGLALTPALVKKAGSMYKVNLTGYCIAFFMRIGFIIGGLIGSIPMMLTFSVISGLCVSPVTGDLNALIAATSDYTYRTKGKRIDGTMFSCSSLGIKIGGGLGTALAGMLLEAGGYVANAPVQSASCINMLKFMYLGFPFITVIITTIILSRLKVEKANEDWDREHAVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7S8</accession>
    <name>F7K7S8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein HMPREF0994_01973</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01973"/>
    <dbReference type="EnsemblBacteria" id="EGN41378">
        <property type="protein sequence ID" value="EGN41378"/>
        <property type="gene ID" value="HMPREF0994_01973"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2168"/>
    <dbReference type="eggNOG" id="COG3022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061989_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="35484" checksum="899D14F618886ABC" modified="2011-09-21" version="1">MTPLTGSTDRPGQLEGCNPRRHSDRKGRAGKAISREGRRRNRMRDMRFIISPAKKMIVDRDTMEVGGKPVLLGKTEVLLEWMRGMDEGELKVLWRCNDKIAALNYERIRSMDLEKGLTPALLAYEGIQYQYMAPGVFEDGAWAYVQEHLRILSGFYGILKPLDGVVPYRLEMQAKGNPGGEGNLYDFWGDAIYKELVSETDCIVNLASKEYSRCVEDWLEEGVEYITCVFGEEKEEGTAEKDGKKKGIPVVQKGTQAKMARGEMVRFAAGNNIRDWRSLKDFCGLGYTYREEYSSEKQLVFVKNKEIRETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7T8</accession>
    <name>F7K7T8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication protein DnaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251896.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01983"/>
    <dbReference type="EnsemblBacteria" id="EGN41388">
        <property type="protein sequence ID" value="EGN41388"/>
        <property type="gene ID" value="HMPREF0994_01983"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2180"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="173"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="323" mass="37578" checksum="F42D53F1BF3F5BF2" modified="2011-09-21" version="1">MALTNTQYNSIMRLYEQRQTKNRHLRDERLHYVYNHVTGYRNLDESVATLSVAQGKKMLNGDLNALSELKERLHKLTSDKRKLLCDAGLPSDYLEPIFDCPDCQDTGYVNGIKCHCFRQAEIELLYQQSNLKEVLEKENFNTLSFDYFQGEDLAAFQTAVKRCQDFARTFSHSGSNLFLYGTVGTGKTFLSNCIARESIESGHSVIYFSASSLFDTLSRNAFDFKNQETLDYLYNDLYNCDLLVIDDLGTEQHTPYNVSRLFTCLNERLIRRKSMIISTNLSLPDLKERYQERIFSRITSNFEFCKLTGPDIRMYKKRLTNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7W9</accession>
    <name>F7K7W9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02015"/>
    <dbReference type="EnsemblBacteria" id="EGN41420">
        <property type="protein sequence ID" value="EGN41420"/>
        <property type="gene ID" value="HMPREF0994_02015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2212"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="34478" checksum="EA9AF8BAC8849253" modified="2011-09-21" version="1">MKKEWDSNKIFKGIFPALLTPITEEGIIRRDGLKKLIDWELYHGADGFYIGGATGECYSMETEAREELAKEALRAIDGRGRCIVHIGAYSVREGIRLARQAEKAGADAISATPPPVYRYGMEETVDYYRQLSEAVDIPMLVYVNYMLGEQDPTVLMEKVLELPGVIGMKFTRNDYYELFRISRLQGGNINLLNGPDETLLCGLVMGADGGIGSTYNIMPGIYKKIYGAFRKGDMRSARNWQFQADNIIEVLLKYGQIRAMKFLFNRKGISLGKAEKPAVDLSDGEKQQLLCELEAAGYFREYPEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K810</accession>
    <name>F7K810_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="7" type="ORF">HMPREF0994_02057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251970.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02057"/>
    <dbReference type="EnsemblBacteria" id="EGN41462">
        <property type="protein sequence ID" value="EGN41462"/>
        <property type="gene ID" value="HMPREF0994_02057"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2258"/>
    <dbReference type="eggNOG" id="COG1904">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044465_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="479" mass="54874" checksum="9AA1585F7D714F51" modified="2011-09-21" version="1">MKAFMNQDFLLSSETARTLYHTYAEQMPIFDYHNHLSAQEIYENKSFTNLTQAWLYGDHYKWRAMRTAGFPEELVTGPRGELSPGEREESDCRRFRAWAETIESSIGNPLYHWTHLELQRYFDVTTPLSAETHEEIWNTCNAKLSSPAFSVRNLLKKQNVQILCTTNDPCEDLHYHRLLREEGFSVQVLPTFRPDKAYLIGKEDYPQYLDSLGKAWGNPISCLSDLKEALCSRLDFFIREGGCLLSDHSLEGCIYAPASDEEAQDIFARRMEGSALTLDERRRFQGNVLTFLGKEYAARDIAMQLHIGALRNNSSRMLKAVGPDTGFDSTDDFLYAGELSALLNSMDSTGQLPKTILYCLNQRDYEMLAAMCGNFQSAPFRGKIQFGTAWWFCDNKRGMEAQLEVLASLSLLPVSIGMLTDSRSFLSFPRHEYYRRILCNKIGQWVEEGEYPCCMEYLGKVVQNICYNNALQYLKGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K884</accession>
    <name>F7K884_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation transcriptional regulator SpoIIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251770.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01857"/>
    <dbReference type="EnsemblBacteria" id="EGN41262">
        <property type="protein sequence ID" value="EGN41262"/>
        <property type="gene ID" value="HMPREF0994_01857"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2034"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174628_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014208">
        <property type="entry name" value="Spore_III_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12116">
        <property type="entry name" value="SpoIIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02844">
        <property type="entry name" value="spore_III_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="88" mass="10111" checksum="7B05331112703C8B" modified="2011-09-21" version="1">MKDYIEERAIDIANYIIDYNATVRQTAKQFGISKSTVHKDVTERLSQINPALAREARKVLDVNKSERHIRGGLATREKYLHQSQNGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K888</accession>
    <name>F7K888_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS system, ascorbate-specific IIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251774.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01861"/>
    <dbReference type="EnsemblBacteria" id="EGN41266">
        <property type="protein sequence ID" value="EGN41266"/>
        <property type="gene ID" value="HMPREF0994_01861"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2039"/>
    <dbReference type="eggNOG" id="COG3037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031784_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="423" mass="45256" checksum="F12AD54F3FD04DD3" modified="2011-09-21" version="1">MVVLNFIINEIFGQGAIFLALIAMIGLILQKKQFSEIVRGTMMTAIGFFVLSQGTGIITGNSIDGLAAAFNTMMPAASGKPDIDMSVYGTQIGIVMLIAFAFNLLFARFTKWKSVFLTGHMLYWFPYVFIAAGVDAGLTGGKLIGLATIFTAAYMVISPNLMRPLVREVTGDDSFTIGHPTTVLSLISGYLGKLIGDKKHSTEDIKFPKSLGFLREVSITGSIVICLTYIVMFFILKANGLVPGEVWGYAGGTTGIFTFIFTKAIYFGVGVTIMLLGVRMLISEIVPAFKGIAEKIVPGAIPALDCPVIFNFAPNALIIGFIVAMITSTITIILTAGMFPTVIIPLTFTCFFEIGCASIIGNATGGIRGCIVGAALSGIIMVFLVGFGSYFFGNTINNWMLVYGGQDFSLWGIVEGAIARLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8A6</accession>
    <name>F7K8A6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251792.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01879"/>
    <dbReference type="EnsemblBacteria" id="EGN41284">
        <property type="protein sequence ID" value="EGN41284"/>
        <property type="gene ID" value="HMPREF0994_01879"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2059"/>
    <dbReference type="eggNOG" id="ENOG503194H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130373_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024208">
        <property type="entry name" value="DUF3842"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12953">
        <property type="entry name" value="DUF3842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="139" mass="14317" checksum="9DE15B561A70F41C" modified="2011-09-21" version="1">MKILIIDGQGGRMGGLLAEKIKKAAIPGAEIYALGTNSAATTAMLKAGADYGATGENPVLVNCRDADYIIGPLGIMAADALLGEVTPAMATAVGQSRAMKILLPVNKCSQHVVGVTDYSMSELTEQALSYLLSCIQGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8E9</accession>
    <name>F7K8E9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_02129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252042.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02129"/>
    <dbReference type="EnsemblBacteria" id="EGN41036">
        <property type="protein sequence ID" value="EGN41036"/>
        <property type="gene ID" value="HMPREF0994_02129"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2332"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052027_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="10">
        <location>
            <begin position="35"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="34142" checksum="930212AF878AE691" modified="2011-09-21" version="1">MQTITFSAIEKLDFRTKESYKTLRTNLEFSGKDRRVISITSSTPNEGKTSVSFQLAMSIAEGGKKVILVDADLRKSVLKGRYKSNAARYGLSHYLSGQASISDIFCKTNIPNFYVIFSGPVPPNPSELLGNDAFGLLLEYLRKEYDYVIVDTPPLGSVIDGAVAARYCDGTLIVIESGAISYKFAQKVTEQLEKVDCRILGVILNKVNMSGKGYYGAYYGKYYGKYYGKYYGNNEEGGLHAAVVQKGLKSGKAAKGEENTHSHEIKNGSDPVKEKIPEESQIPEDDMIQLDIDMVELTEDTEPIEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8F1</accession>
    <name>F7K8F1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252044.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02131"/>
    <dbReference type="EnsemblBacteria" id="EGN41038">
        <property type="protein sequence ID" value="EGN41038"/>
        <property type="gene ID" value="HMPREF0994_02131"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2334"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="405" mass="45332" checksum="889AC32C8EE43F44" modified="2011-09-21" version="1">MDSKKRILFVVEAMGGGVFTYIVDLANGLVDKYDMYIAYAVRPQTPSGYKDYFDKKIHLIEVKNFTRSVESSKDIKAFLEIKRIADKVKPDIIHLHSSKAGALGRWAFNGKKTPLFYTPHGYSFLMKNHSAVKRFTYKMIETVSGVRSCTTISCSEGEHQETLKLTKRATYVDNGINMEQLDSLLTSIQSDENHPFTVFTLGRICYQKNPMLFNEIAKALPGIHFLWIGDGELREELTSSNIGITGWLDRKNALSRSVSADVFLLTSLWEGLPISLLEAMYMKKPCVVNDVIGNHDVIHSGVNGYVCQNVSEFVESIENAQGDKSAGLVDAAYEDILNKYNTVIMAEKYSAIYDEALVRFGGGYYYLVYIQSATFISLTVHSLPTANIQITLWSTTAAVHEKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8H9</accession>
    <name>F7K8H9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stage V sporulation protein D (Sporulation-specific penicillin-binding protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252075.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02162"/>
    <dbReference type="EnsemblBacteria" id="EGN41069">
        <property type="protein sequence ID" value="EGN41069"/>
        <property type="gene ID" value="HMPREF0994_02162"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2366"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="245"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="584" mass="64623" checksum="78A28464095D3D33" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8M5</accession>
    <name>F7K8M5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HMPREF0994_02213</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02213"/>
    <dbReference type="MEROPS" id="S11.005"/>
    <dbReference type="EnsemblBacteria" id="EGN41120">
        <property type="protein sequence ID" value="EGN41120"/>
        <property type="gene ID" value="HMPREF0994_02213"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2417"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_8_0_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363578" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="16">
        <location>
            <begin position="287"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGN41120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="396" mass="42887" checksum="1860C6EE24BAB1A1" modified="2011-09-21" version="1">MNCVKQKAIAKKLISFMLVICLIGMPEIKGYAQEGAPVSISAPSAILMEASTGTVIYEQNADASCSPASITKIMTMLLIFEALDRGDIKLEDEVMTSAHAQSMGGSQVFLEEGEMQTVDTMIKCIAVASGNDAAVAMAEFIAGSEEEFVSRMNERAEQLGMQGTHFEDCCGLTDSDNHYTTARDVAAMSRELITKHPAVFNYTMIWMEDITHNTARGSSTFTLSSTNKLLKQYQWTTGLKTGSTSKAKYCLSATARKDDIDLIAVVMTAPDYKVRFSDAATLLNYGYSVSALYKDENKDALPRLIVDGGVAEDVGLVYKEGFSYLDVKGNDLSAVEKILNLPGAARAPIEAGEKAGEAVYRLNGETIGTVPVLFAESVAEAVYKDYVLKVLGYFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8P3</accession>
    <name>F7K8P3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252133.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02232"/>
    <dbReference type="EnsemblBacteria" id="EGN41139">
        <property type="protein sequence ID" value="EGN41139"/>
        <property type="gene ID" value="HMPREF0994_02232"/>
    </dbReference>
    <dbReference type="GeneID" id="29724231"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106729_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="149" mass="17683" checksum="BA1BF23311CE1D83" modified="2011-09-21" version="1">MKINQFRDPGLEEDYMDVHYREYNDEIRRILALTESGNTLWGKREGVQSCLSPEEIYYFETVDRKCFACLKEEVYQVEFGIQSAVERFGPLGFVRISKSAAVNVYKVRQLTADMNMRMQLLLDNGEKVVLNRSYKNEFLQFIKERRMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K925</accession>
    <name>F7K925_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252264.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02363"/>
    <dbReference type="EnsemblBacteria" id="EGN40762">
        <property type="protein sequence ID" value="EGN40762"/>
        <property type="gene ID" value="HMPREF0994_02363"/>
    </dbReference>
    <dbReference type="GeneID" id="29726367"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2586"/>
    <dbReference type="eggNOG" id="COG3359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047529_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="369" mass="42321" checksum="A6F2F99E195ED348" modified="2011-09-21" version="1">MKTRIQTLHTTNENAIRQFLGKDGNILFFDIETTGLSPKNASVYLIGAAVIEDKKWTLHQWFAENTAEEEAILDAFLQFSVPYKKLVHFNGTTFDIPFLQAKCKKYGLTASFAEMEQTDIYRQISPFKNLLKLSNCKQKSLEEFLGLNREDPFNGGQLIELYKVYRQERDHRLLEVLLLHNADDLRGMLSVVSILSYPALFAMHPENARAELDIGTDYEGNRQKELLLYLQLPVFLPVPLALHAGGCFFSAKEDSGVLKIPVYSGELKFYYPDYKNYSYLPEEDKAIHKSVAVYVDKAHRVPATPATCYTKKEGDFLPQHLLPSQDDLFTPAFRREVKEKESFFLLEEAFLNDSGRLSLYAHHILNGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9G5</accession>
    <name>F7K9G5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252426.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02525"/>
    <dbReference type="EnsemblBacteria" id="EGN40924">
        <property type="protein sequence ID" value="EGN40924"/>
        <property type="gene ID" value="HMPREF0994_02525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2768"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086901_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="228" mass="24742" checksum="1C1F22311483F556" modified="2011-09-21" version="1">MEQCKIINLYDLNETIAAPVFEGFTYPWEVLPEIKSFIPELGKTLPADRFDKVGENVWIAKSAKVAPSAYINGPAIIDEEAEIRHCAFIRGSAIVGKGAVVGNSTELKNVILFNKVQVPHYNYVGDSILGYKSHMGAGSITSNVKSDKTLVVVRCNGEECHTGLKKFGAMLGDNVEVGCNSVLNPGTVIGRGTNIYPTSMVRGFVPADSIYKTKTEISEKSHDEGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9I0</accession>
    <name>F7K9I0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40940.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02541"/>
    <dbReference type="EnsemblBacteria" id="EGN40940">
        <property type="protein sequence ID" value="EGN40940"/>
        <property type="gene ID" value="HMPREF0994_02541"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356485" evidence="1">
        <location>
            <begin position="33"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40940.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="264" mass="28229" checksum="47BBABEE5FE0F7A8" modified="2013-09-18" version="2">MKKNRWTAILMAVILCFGLAFAGNGRLENVQAEESKTVTLYLTRHGKTMLNNTGRMQGWCDSPLTQDGAAVAEKLGQGLKKAGIFFDAAYSSDSGRAIETADLVLRNCGQEALTLKKEPMIREVCFGIYEGATPPEAYGAASEALGFSSVEDMMGAVFGGKISIYDAVTAMANTDETGSAETWGEAQQRVVEGIVKIAEEARLNGQKNVLVVSHGMAISAFLSAVNPEIVVGELGNASITKIVYDGKTFTVESVNDMSYVKDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAF4</accession>
    <name>F7KAF4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02780"/>
    <dbReference type="EnsemblBacteria" id="EGN40389">
        <property type="protein sequence ID" value="EGN40389"/>
        <property type="gene ID" value="HMPREF0994_02780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096795_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="19197" checksum="3034AE9D65BD5582" modified="2011-09-21" version="1">MIGVKGGPVQLVLAQRSDAQLIHGLKREAFMPLYEIYRDDETSPVMDTVDKVVCQLAQEDTDYWLIVYEGRMVGGVRVVRKKDANLISPMFVLPEEQNKGIGSAVLEQLFQMYPETFCWRLVTIQEEERNCHLYEKMGFCNTLSARKVSGNMTLIGYERFFKESSGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAT8</accession>
    <name>F7KAT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252868.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02967"/>
    <dbReference type="EnsemblBacteria" id="EGN40345">
        <property type="protein sequence ID" value="EGN40345"/>
        <property type="gene ID" value="HMPREF0994_02967"/>
    </dbReference>
    <dbReference type="GeneID" id="29724328"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3240"/>
    <dbReference type="eggNOG" id="ENOG5032M0R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1173813_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356770" evidence="1">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="232" mass="22983" checksum="88C310ED6FC2FFF7" modified="2011-09-21" version="1">MKKKMAIVLSAILACSMGMTAMAAPSPSIQKEPVAQVVVSPSVGTNNTVTTQAVSVSSDKSAVLPGTTFKTASGQIVDPSAVAMVIAPASAEQAQASAASLAAALASSKMQVVNFTGRSGLSLTDANGNLNVVNNMVIGLQTASGEAVAQNGSVSAAFALSDILGAAALGEGETLQALYQRADGTWVAVPVVIKNGAVAVALPAFGGAVNVTFVVAKGAHMEDVPATTSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB10</accession>
    <name>F7KB10_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252940.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03039"/>
    <dbReference type="EnsemblBacteria" id="EGN40216">
        <property type="protein sequence ID" value="EGN40216"/>
        <property type="gene ID" value="HMPREF0994_03039"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3319"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103773_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="183" mass="19226" checksum="8EE98253FD5DC2D3" modified="2011-09-21" version="1">MDEELIARTVREVLQEIGRMEASAENSVSMDAKKAVNGYIHGYIHGMSLRLAEALAAKVEEKAEELGMRVVTAVADEAGHPKLVRSMDGAYIGSLDVAVNKAYTCAAFQMSTAVLGELARPGEPLYGIQHTNGGRIVIFGGGEPLIYNGKIIGALGVSGGTAEQDTSLAAYGASLLKEVISCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBB4</accession>
    <name>F7KBB4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03143"/>
    <dbReference type="EnsemblBacteria" id="EGN39973">
        <property type="protein sequence ID" value="EGN39973"/>
        <property type="gene ID" value="HMPREF0994_03143"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3436"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="162" mass="18913" checksum="F7541A1D05146774" modified="2011-09-21" version="1">MDEKISMDGRISIEKRDVREAMVEMETARRQILHPYFQDLGLSPGQPRILNKLYEKDHVTQRELADKCFMDVATMSRNLDRLEEAGYITREKHPDCRRSFLIVLTKEGRNRAAQVYEDFRLIDEKIWQGFTEEEMAVFLSCAKKIIGNLKSETEKTPESPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBH8</accession>
    <name>F7KBH8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40042.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360251.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03212"/>
    <dbReference type="EnsemblBacteria" id="EGN40042">
        <property type="protein sequence ID" value="EGN40042"/>
        <property type="gene ID" value="HMPREF0994_03212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40042.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="217" mass="24594" checksum="51D32649CA8A77C1" modified="2013-09-18" version="2">MKTFLKPLSKEEESACLEALRGSDGVKAREAKQVLIERNLRLVAHIAKKYQNVDEDMEDLISIGTIGLIKAVESFDASKNSKLATYAARCIDNELLMMLRSKKKTSREVSLYDPIGTDREGNEISLLDVTPQEQPDIVDQMELERSLGKLSGLINSLLTDREKEIICLRYGLCGGEEVTQREIGKKLNISRSYVSRIEKRALTKLREGFEKMEVHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBW0</accession>
    <name>F7KBW0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253258.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03357"/>
    <dbReference type="EnsemblBacteria" id="EGN40187">
        <property type="protein sequence ID" value="EGN40187"/>
        <property type="gene ID" value="HMPREF0994_03357"/>
    </dbReference>
    <dbReference type="GeneID" id="29728659"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3669"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="33073" checksum="7B5B74F3C697FCE3" modified="2011-09-21" version="1">MKRNPNKIKLSKEELIYQAVISLFLILFLIICIVPFLYVLGMSFTSEGEMIQRNYFVIIPREPILAAYKYVLNKKFFLSMGVTVARTLLGVVAALALAVPAGYILAKQDLPYRSACMIFFIITMILNGGLIPNYMLMTRLKLLDSFWVYIVPAFANTYGILVVKLFVEGIPSDVTDSAELDGASELQKLVYIAIPLLKPTLCALGLFAAVTHWNAWFDALVYIRNEALYPIQLVIRNLLIASSSGDMMSNVNTYAKMTSESIKMASVVIAVLPILCIYPFLQKYFVHGMYTGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC30</accession>
    <name>F7KC30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253310.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03409"/>
    <dbReference type="EnsemblBacteria" id="EGN39916">
        <property type="protein sequence ID" value="EGN39916"/>
        <property type="gene ID" value="HMPREF0994_03409"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3727"/>
    <dbReference type="eggNOG" id="ENOG502Z89K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865430_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="320" mass="37092" checksum="EFA93A63BF2E315A" modified="2011-09-21" version="1">MIGKYQIIIQNKRIRYEFVIKRNITIIRGDSATGKTVLVEMIREFQENGIASGIELTSEKKCAVLSGQTWKVQLSAIQDSIVFIDEGNNFVGTKEFAAYIQHTDNYYVIVARESLSALPYSVEEIYGIRNSGKYGSLKRTYNELYHLYGKQDYYHPIKPEMVITEDSNAGFQFFNHLCRKRGKPCISASGKSNIFMVALNSKDDIVLIIADGAAFGSEMEKMVKLMEIEDRFHLYLPESFEWLLLKSGILQDSDLKKLLDEPYNYIESSENFSWERYFTKVLINKTADTHMKYTKHILNPFYLQEKNVEKVMHTIERIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCD1</accession>
    <name>F7KCD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253408.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03507"/>
    <dbReference type="EnsemblBacteria" id="EGN39580">
        <property type="protein sequence ID" value="EGN39580"/>
        <property type="gene ID" value="HMPREF0994_03507"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3834"/>
    <dbReference type="eggNOG" id="COG3246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065536_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="31079" checksum="97C2B490FE763B00" modified="2011-09-21" version="1">MRKVIISLAPVEAGLPVDKEALAEDVVRSAAAGAAMCHLHCRRPDGSLTPDVTEMADTFDRIAERTDLIIQASTGGVSDMDIRQRCYPLDYWRVESASLNGGTTNLGEAVYINTFEDIRYCAKAVYEREIIPEIEVFDIGMIYNIRMTQQEVPYRNPVLYNLVFGHKGGMQPNMECLTAFRAAVPADALWGVTHYGRDNWEFLAAAIAMGAAVVRIGFEDSRYLAPGRTARANYEEVEKLAALIRAMDLETASPEEARRIMNIPSGKKKPNTPPQAAGHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCE5</accession>
    <name>F7KCE5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03524"/>
    <dbReference type="EnsemblBacteria" id="EGN39433">
        <property type="protein sequence ID" value="EGN39433"/>
        <property type="gene ID" value="HMPREF0994_03524"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3850"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="35464" checksum="85450FEA3654550F" modified="2011-09-21" version="1">MEEILYYKMGSACLPVIKYTNKVHVEPPHVHIRRQLEEYVLYFLLSGDMYLKEGKRDYHLEAGDMLILDPRLEHRGTKAAACTYFYIHFYQEQLEECRTTADTIKNEALARRFASLQTDECTIRNMPSAPLLLPKHLHISKPGVLLHMTELLEQITASHYNKLEYFRLQTGCLFMEFLLAASRELTDSFLLEGDSTFTARSTKIIYDIMTFFQSSYAGDITGCLIEQKYGCNYDYINRLFKKATGKTMLAYLNELRISKARQLLSDGTSRISDVAEKCGFRDIYYFSRVFKKYTGTTPGAFTRNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCN0</accession>
    <name>F7KCN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253510.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39204">
        <property type="protein sequence ID" value="EGN39204"/>
        <property type="gene ID" value="HMPREF0994_03609"/>
    </dbReference>
    <dbReference type="GeneID" id="29728361"/>
    <dbReference type="eggNOG" id="ENOG50327P3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168837_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="86" mass="9655" checksum="A8CFAD7661230DDF" modified="2011-09-21" version="1">MAITSLDILNLSHSLKDLCDVNCKQTECLTQTLQFLLEYNLIQANLEFSRQFSCPGDSRPPLSPSVSVAKERRLEKDVSEIDALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCY3</accession>
    <name>F7KCY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MR_MLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03712"/>
    <dbReference type="EnsemblBacteria" id="EGN38876">
        <property type="protein sequence ID" value="EGN38876"/>
        <property type="gene ID" value="HMPREF0994_03712"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760266_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="152"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="382" mass="43176" checksum="FACF483E45D18A28" modified="2011-09-21" version="1">MKQSCCELWNQELKRHQIERVQFYRCRARYPRLHGKNAIRGYHGFGGEIEVAKLTTKDGITGWGQLSRGVDEAKRNKELLLKRPLTELFDSGTGILDERLLAFDIPLHDLAGKILGIPVCRMINPDSVLRAPVYDGAIYMNDIIPEDAPFGVDRVIQESVDDVRLGHTILKVKIGRGHRWMEHGEGMARDIEIVRRIHETLPGIAIMVDANDGYTLEDAIAFLEGIGDTEIFWFEEPFREEEGKNRLLKDYLLKERPGTLIADGESDTDIPLLRGLAEKKLLDVWQPDVCGYGFTKWRTLMKEISQNGWLASPHAWGNVTKTHYCAHLAAAYPHHIPCVEAVLGSIEGVDFDGYCLERGTMRIPDKPGFGMDLIWAGEITDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCY6</accession>
    <name>F7KCY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03715"/>
    <dbReference type="EnsemblBacteria" id="EGN38879">
        <property type="protein sequence ID" value="EGN38879"/>
        <property type="gene ID" value="HMPREF0994_03715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4055"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356535" evidence="2">
        <location>
            <begin position="28"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="563" mass="62245" checksum="EE52D8C1D9D0DE8C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD04</accession>
    <name>F7KD04_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253634.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03733"/>
    <dbReference type="EnsemblBacteria" id="EGN38897">
        <property type="protein sequence ID" value="EGN38897"/>
        <property type="gene ID" value="HMPREF0994_03733"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4075"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="31451" checksum="BF261FD4F36F384B" modified="2011-09-21" version="1">MALKAVQQIMLGTVTKNETQATETLRAIRQAGYDGIELNGFMIRPTPFLVRMMTKMAGMPVGKGGNFDWKKLVDQAGLSVVGIHEDLGTIQRETEKVIAQAKDFGTDKVIITGMYRFDYSDKEAVLRLAQDLNREGEKLEKAGIRLLYHNHNCEFRKVEGDRTAFDYLAEETDPAYVGFEFDSYWPTEAGVSAIAFMKKLGGRMKLYHINDRGTRITGASMTPILKSDSMELGQGNMNVKELLGQALSAGVDAVVLESHKNWAEKSPIKSLQISAEFLKKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD85</accession>
    <name>F7KD85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_03814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03814"/>
    <dbReference type="EnsemblBacteria" id="EGN38579">
        <property type="protein sequence ID" value="EGN38579"/>
        <property type="gene ID" value="HMPREF0994_03814"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="348"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN38579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="596" mass="67926" checksum="7335FA4E859A9B0E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDV0</accession>
    <name>F7KDV0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe-ADH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253930.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04029"/>
    <dbReference type="EnsemblBacteria" id="EGN37718">
        <property type="protein sequence ID" value="EGN37718"/>
        <property type="gene ID" value="HMPREF0994_04029"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4392"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="6"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="385" mass="42325" checksum="0C92897483A60BE4" modified="2011-09-21" version="1">MKLYMPTKVYSEKNCVENHSRELAALGTKAMVVTGKHSSRINGSLEDVTGALERERVPYVVFDDIEENPSVETVMRARALGIKEGADFVIGVGGGSPMDASKAIALMMANPEHDERLLYTKAQVSAQGPVYPAFPVAEVPTTAGTGSEVTPYAILTKNVLPDIVLTTVPGAAAQGAFSHLEKKTKQSISHHIFPALALVDVSYLQTASRSGCIHTAVDTLAHLIESHLNTNTTSYSRIYSEMGLRTWARIKDKLLRYEIGEEEREALMRACTLGGMAITHTGTSLPHGLSYPITCEMGLPHGKAVGIFLPGFIRNYGDQEEVMKMLSLLDFGGVQPFSEYIRQLLGEVSVPEELWERTMDEVLANPAKLKNYPFMLDREHLQLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDX0</accession>
    <name>F7KDX0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253950.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04049"/>
    <dbReference type="EnsemblBacteria" id="EGN37574">
        <property type="protein sequence ID" value="EGN37574"/>
        <property type="gene ID" value="HMPREF0994_04049"/>
    </dbReference>
    <dbReference type="GeneID" id="29729535"/>
    <dbReference type="eggNOG" id="ENOG5032T4T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249303_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="221" mass="26399" checksum="529B2BA230467484" modified="2011-09-21" version="1">MATWMVHLRIADGIMKEIPKLERQEFIMGNIAPDSGVPNEDWSVFTPNTNVSHFKTDGEITVPLFRDKYMNKELWAGYSEKEKSFFLGYYVHLLTDVLWKENIVDPSIQRFSELFEKDKDAIWKLKEDWYDLDHLFLKKNPCFRTFLEYENAVGFTNTFMEEFAEDALDNRRAYVSDFYREKHENLEREYPYLNEQEMGLFVGNTIELLTQRLIEEKWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEC4</accession>
    <name>F7KEC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN36483">
        <property type="protein sequence ID" value="EGN36483"/>
        <property type="gene ID" value="HMPREF0994_04203"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203763_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="55" mass="6202" checksum="9AD862D3181C8871" modified="2011-09-21" version="1">MSKNDYNQNSQNSEKQNQQNKSENSSSNSQKNQNQSKNSSSDCHNGSNSSKENNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KED0</accession>
    <name>F7KED0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar (Glycoside-Pentoside-Hexuronide) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254110.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04209"/>
    <dbReference type="EnsemblBacteria" id="EGN36489">
        <property type="protein sequence ID" value="EGN36489"/>
        <property type="gene ID" value="HMPREF0994_04209"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4594"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="238"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN36489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="461" mass="50004" checksum="DCE31769B349B401" modified="2011-09-21" version="1">MSEKAAVNGQKNFVEKISTFEKIAYGGGDLASNFVLVLTGTFVTFFYTDALGLNAAIVGAIMMFSRLADGFTDIIMGYIMDKTHSKHGKARAWLLWLSIPIGIATILVFLVPNIGVTGKYIYIAITYNLVTTFLYTMINIPYGALTSLMSRDQDQRMIINIFRMFMAQAGSLIINACTLPLVNAMGGSTKQRSWIIVSILYGVVAAALFLLCFAKTKERVRVQAEKNNELGFLTSFKLIVKNNYWLLLVGIWVSMVLGMSMSGSVGTYYAKYILGNENIAGFLGALGIVPVLIIMPLTAPLNRKFGKRNVALYGSFVSIAGQLLMLLNPASAAWLMFCAVIKGIGSATLSGTMFAMIADTIEYGHWKTGTRVEGMLYSSTTFGAKVGAGVGGAVALAVIGAAGYDGLAAVQAPAALEAIKVLYLIVPIPFVIIIPILYACYKLDKIYPKVMEELNQREQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KED3</accession>
    <name>F7KED3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M56 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254113.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04212"/>
    <dbReference type="EnsemblBacteria" id="EGN36492">
        <property type="protein sequence ID" value="EGN36492"/>
        <property type="gene ID" value="HMPREF0994_04212"/>
    </dbReference>
    <dbReference type="GeneID" id="29729768"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4597"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010662_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="15"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="578" mass="65481" checksum="E351DF3300F9498F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEL4</accession>
    <name>F7KEL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254194.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04293"/>
    <dbReference type="EnsemblBacteria" id="EGN36105">
        <property type="protein sequence ID" value="EGN36105"/>
        <property type="gene ID" value="HMPREF0994_04293"/>
    </dbReference>
    <dbReference type="GeneID" id="29724890"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033229_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363700" evidence="1">
        <location>
            <begin position="32"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="591" mass="66288" checksum="C2ECFF64D89033AE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEU7</accession>
    <name>F7KEU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04380"/>
    <dbReference type="EnsemblBacteria" id="EGN35690">
        <property type="protein sequence ID" value="EGN35690"/>
        <property type="gene ID" value="HMPREF0994_04380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4779"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057834_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09024">
        <property type="entry name" value="Aldose_epim_lacX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037481">
        <property type="entry name" value="LacX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="28634" checksum="383CDCA79A33967B" modified="2011-09-21" version="1">MNYTIENDRLKIQISSRGGEMQSVIRDGREYLWQADPQYWDEKAPNLFPYIARMTEGKYVLDGKSYPMPLHGFVHVTELSMEEQTADRIVFRLDSDEETGKCYPFAFTYRVIYELDGDVLHITYQVENHDEKTMYFGIGGHPGFLVPMEDSLGFEDYYLEFEGTKDYDEPVRIGFSPDCFVDGGVTPFPLTDGSKIPLKHSLFDNDAIVLTHTPKTVSLKSDRGTRRVTVSYPDMDYIGFWHATLTEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFC6</accession>
    <name>F7KFC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose_iso_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04555"/>
    <dbReference type="EnsemblBacteria" id="EGN35324">
        <property type="protein sequence ID" value="EGN35324"/>
        <property type="gene ID" value="HMPREF0994_04555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4972"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045643_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_C" evidence="2">
        <location>
            <begin position="378"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="54276" checksum="E3DCC5CD05850C2B" modified="2011-09-21" version="1">MGIREKYRDKYRVKIGFVPTRRETFSETAFRLDKAAETKKKVEERLTAMQVDYVNIDFLNEEGLLYRSRDAEKVAEYLNQQKVDAIFIAHVNFGCEEAVARLASMVRKPVLLWAVRDDAPEPEGYRFRDAQCGVFASSKVLSRFDIPFTYLTNCYTEDVKFENGIRNFLAAAGVAKAFNAPRIGQISVRPAAFWSVKCNEAELLERFGVEVVPITLVEMQKRYQDILQKKGTDFEEELDYIMSKVKAECVGREALESICAMKLAVFNWAEEENLRAAATQCWAPFTDISGIAPCYLMGDSTDDGFPIACENDIHGALTAIMALGANGASEPPFFADLTGRHPTDDNAELLWHCGVFPPGLANEKGVTIGCHQGKGYKGAGQFELKQGDITLLRFDSLKGDYKLLFGEGKTTQGPYSKGTYVWAKFNDWPAWERKFVCGPYIHHCTGVYGSYAHVFQEAVKYLKGVEPDPVYPAQETLNERWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFK3</accession>
    <name>F7KFK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254533.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN35079">
        <property type="protein sequence ID" value="EGN35079"/>
        <property type="gene ID" value="HMPREF0994_04632"/>
    </dbReference>
    <dbReference type="GeneID" id="29726779"/>
    <dbReference type="HOGENOM" id="CLU_135495_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="177" mass="21007" checksum="BCC79675AF2E7C34" modified="2011-09-21" version="1">MYDEKTREKLIRETAESIYQYYPMACKMVICFLSYNNRKVSGYVKSVYYDNRPFYFEGLDHLLLLMEDIMDTTDYPQVTVDYHNLKGKTFKRQSDIFKAYDDRKMVSLFEDEEIKDAGPKKKIACVQVISRKNSSIQGELSINAKVKVFFRSGIELMQLLYELMEDWQRETSEPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFM3</accession>
    <name>F7KFM3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254553.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04652"/>
    <dbReference type="EnsemblBacteria" id="EGN35099">
        <property type="protein sequence ID" value="EGN35099"/>
        <property type="gene ID" value="HMPREF0994_04652"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5082"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115794_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="24392" checksum="F5BDC7D57D1D296D" modified="2011-09-21" version="1">MELILSSITTACVNLLVFSFIPFLWWFFRHRKEISFFKWLGFIRPQLKSKWWTLLLFAVVYYFFYTFDFTQWISPETMEYLENSGSVSVNAFAGIGAAAILPAFIENFIGNGVAEEILYRGFFCKRFCNKLGSVKGILLQAVLFGLMHNALYLLAGLQVGLWYHMLMFLFTGMAALLLGWLNEKIFNGSILPGILLHGAGNFINSMLMAFSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFN1</accession>
    <name>F7KFN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04660"/>
    <dbReference type="EnsemblBacteria" id="EGN34871">
        <property type="protein sequence ID" value="EGN34871"/>
        <property type="gene ID" value="HMPREF0994_04660"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169481_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="26514" checksum="68C9C4F6787C839F" modified="2011-09-21" version="1">MNDSEKMDLILNIGMEISEQMKAANGRMEVMEGGMSTLSEQIGDLTGRVDEFAEQAAALTEQVSAMAGGMDTLTGQVSVLAERMDTLMGRMDTLAEQVDTLTGRMDTLAERVDTLTERMDTLAERVDTLTERMDTLAERVDTLAERMDILTVRVNTLTSRMDAQEARMDNMSEQIDSMADQIKKINNRIDFLELQIKSTESNLKSEIHKSEGLILDEVERIHNILNRHMADPKAHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFZ0</accession>
    <name>F7KFZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04769"/>
    <dbReference type="EnsemblBacteria" id="EGN34396">
        <property type="protein sequence ID" value="EGN34396"/>
        <property type="gene ID" value="HMPREF0994_04769"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089947_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="270" mass="31228" checksum="3785A7440A6696F3" modified="2011-09-21" version="1">MYSLLLVDDERLELETLRDYIAWDELGFDRVYTARGGRDGYDKALRLKPDVMITDIHMPVMNGIELAKQLYADGCTTKVIFLTGYDEFEYAKAALQVEAVDYILKPFSFEKIRKAAERVRELLHKEELLKMSVRVYGKKLLCRVIDKDGETGREACRQFLDVCEWDKEEWFGLITTTAGLDDTVIEQVENSLSEVVYSIRGGVKSVPIFWSVTLWITGNPRSVSAPGWSSWGCMPPWFSIRRSFRLNSFMVRSDIWKVCRSFFFMCRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGI7</accession>
    <name>F7KGI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04966"/>
    <dbReference type="EnsemblBacteria" id="EGN34135">
        <property type="protein sequence ID" value="EGN34135"/>
        <property type="gene ID" value="HMPREF0994_04966"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5423"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104072_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="218" mass="25584" checksum="EE97D9365BD9F0F6" modified="2011-09-21" version="1">MKNRELTVRQLEKQARRLERRRRIRESISQNGGDILHSVNFQKTRKNMQHGKVSVHSHSISVAECSLSIREKLQKLGIRSEERDIIRGALLHDYFLYDWHNHIHKKGWRNLHGFTHPETALNNARKEYQLSPREQDIIKKHMWPLTLVPPLCREAWIVTAADKYCSFLETVEPRLEQMKHLGRHWAVIPRKVTVRPNSETPENNSGQEANGRNTSAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGX3</accession>
    <name>F7KGX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein PII 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255003.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05102"/>
    <dbReference type="EnsemblBacteria" id="EGN33135">
        <property type="protein sequence ID" value="EGN33135"/>
        <property type="gene ID" value="HMPREF0994_05102"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5575"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="108" mass="11998" checksum="CEC4F9C52C070B7D" modified="2011-09-21" version="1">MKMIKAVVRPEKCDQVLNELCGAGYRAVTRFGILGRGKQRGLKVEDVYYDEIPKEMLMLVVEDGDVKKATDIIIKFSRTSDEGSFGDGKIFILPVEKAITVSSGKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH04</accession>
    <name>F7KH04_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_05137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255038.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05137"/>
    <dbReference type="EnsemblBacteria" id="EGN33170">
        <property type="protein sequence ID" value="EGN33170"/>
        <property type="gene ID" value="HMPREF0994_05137"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5614"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="236" mass="26930" checksum="F5EBA87935AD10A0" modified="2011-09-21" version="1">MKNILIVEDDKALAEGIVLVLRQDGFSFQCCHNVKDAKKVLEKNIFDLILLDINLPDGSGLDICRGLRKEERLDPVIFLTALDTELHEVTGFQAGADDYITKPFSLAVLRERVMAALRRGERRSSSGKASPVLREGPFTIDSENQSFFMGDREILLSRTEQKLLMVLIKNKNRILERDTLIEKVWGNDGEFVDENALSVTIKRLRDKLEKDPRKPEYIQTVYGIGYRFQINEGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH31</accession>
    <name>F7KH31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005427021.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05167"/>
    <dbReference type="EnsemblBacteria" id="EGN33200">
        <property type="protein sequence ID" value="EGN33200"/>
        <property type="gene ID" value="HMPREF0994_05167"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5647"/>
    <dbReference type="eggNOG" id="ENOG502Z89W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134858_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025608">
        <property type="entry name" value="TcpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12648">
        <property type="entry name" value="TcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="130" mass="14884" checksum="7D936171E8C46D22" modified="2011-09-21" version="1">MKKIRSYTSIWSVEKVLYSINDFKLPFPITFTQMAWFVVSVFAVMLLGNLPPLSFIDGAFLKYFGVPFALTWFMCQKTFDGKKPYGFLKSVLAYLVRPKLTYAGKPVKLEKEYPAQPITAVRSDIYGISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHB3</accession>
    <name>F7KHB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255106.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05252"/>
    <dbReference type="EnsemblBacteria" id="EGN33285">
        <property type="protein sequence ID" value="EGN33285"/>
        <property type="gene ID" value="HMPREF0994_05252"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5736"/>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031869_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="458" mass="53571" checksum="FA8D8D8736ECEE18" modified="2011-09-21" version="1">MNSELQNCQQTEPCTVEEIRNSLEQSEKGKVYNTAANYKRVLQYDPLLKGAIRKNLLTERIDIVKPLGWYRDSPTLTDVDVKYLLLYFEENYGLTVEKKIIDAVAVIANENRYHPVCDFLNALQWDGTERIRFCLHRFLGSDTDDYTYEALKLFLLGAISRAFKPGCKFEVMLCLVGGQGAGKSSFFRLLAVNDDWFSDDLKKLDDENVYRKMQGHWIIEMSEMIATANAKSIEEIKSFLSRQKETYKIPYETHPADRKRQCVFGGSSNTLDFLPLDRTGNRRFVPVMVYPERAEVHILADEQASREYINQMWAEAMEIYRSGNFRLRFSPAMNDYLKAHQKDFMPEDTKAGQILDYLERYSGSMVCSKQLYKEALGHDYDEPKQWELREINDIMNNAVTGWMAFSNPRYFPEPYRRQKGWERIRNDNEPDNSMDGFQEIPTEEMEQLGLPEEWLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHM1</accession>
    <name>F7KHM1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable butyrate kinase</fullName>
            <shortName evidence="8">BK</shortName>
            <ecNumber evidence="8">2.7.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain carboxylic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">buk</name>
        <name evidence="10" type="ORF">HMPREF0994_05350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + butanoate = ADP + butanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:13585"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58079"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.7" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255193.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05350"/>
    <dbReference type="EnsemblBacteria" id="EGN32791">
        <property type="protein sequence ID" value="EGN32791"/>
        <property type="gene ID" value="HMPREF0994_05350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5846"/>
    <dbReference type="eggNOG" id="COG3426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048716_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00542">
        <property type="entry name" value="Butyrate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011245">
        <property type="entry name" value="Butyrate_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF3">
        <property type="entry name" value="PTHR21060:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036458">
        <property type="entry name" value="Butyrate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02707">
        <property type="entry name" value="butyr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="355" mass="38606" checksum="462A5030933562D9" modified="2011-09-21" version="1">MSYKSLIINPGSTSTKIGVFEDENLLFEETLRHPTEEISKYASIIDQKDFRKEIITDLLKEKNFDINSLDFVVGRGGLLKPIPGGTYKVSDELLHDLEIGYQGQHASNLGGILAREIGDSIGVPSFIVDPVVVDELEPIARYSGCPDLPRRSIFHALNQKAVARRYAKESGIPYEQLNLIVVHMGGGCSVGAHRGGKIVDVNNILDGEGAFSPERAGTVPAGDLVKMCFSGKYTEKEVYKKLVGGGGFNGYVGTNDARIVEDKALEGIPEYVAILDAFHYQIAKDIGAMATVLNGKVDKIILTGGIAYSKVTRDDLQKRVGWIADFVVYPGEDELLALAQGGLRVIKGEEEAKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIB4</accession>
    <name>F7KIB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255400.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05593"/>
    <dbReference type="EnsemblBacteria" id="EGN32418">
        <property type="protein sequence ID" value="EGN32418"/>
        <property type="gene ID" value="HMPREF0994_05593"/>
    </dbReference>
    <dbReference type="GeneID" id="29728573"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6110"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363794" evidence="1">
        <location>
            <begin position="25"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="444" mass="49088" checksum="B3F0401FFB25D0E7" modified="2011-09-21" version="1">MKKKLSIILIATMLASVILGGCSKTEEKPELTSPAEIAEAGEPENVTLAGDPDKGEIEVWYWEEYMNEPIAKVVEEFNKQSPDIKVNLTQIPFSQYWTKLQTALPAGAGPDLYFFVSTYLPYYTSNNMIMDLTDLAYSENGIALDKHSPTAVEKFTYKDRVWGVPLFMDDAVLAYNKRIFDEGGVAYPEGGWTWEQLLDAAQKLTTDDNWGFIAAGSGYPGCTQFVYQAGGHDYIDGMPAVNTDAWKRAIQFNVDLMYKYKVSPTAVQQQETDNYQLFASGKVAMAHMGSWCVSGLVESLGDDVAFCETTQDKEWLTLCNTCAWAMNPESKNPAAAYSFLQFLGGEFTAKAISEKAIPSYMGMGQAWADAFPGVNAEACLQSIDNGHTMNIETLDLINSTEIGQILTDELSNIWFQSKTVEEGLNDAQEAMTKAVMEALEGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIJ4</accession>
    <name>F7KIJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255480.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05673"/>
    <dbReference type="EnsemblBacteria" id="EGN32162">
        <property type="protein sequence ID" value="EGN32162"/>
        <property type="gene ID" value="HMPREF0994_05673"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6197"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="33255" checksum="B6F484DD81628F2B" modified="2011-09-21" version="1">MELRVLQYFLAIAREQSIIRAAESLHLSQPTLSTQIKNLEEELGKQLLIRGTKGSRKVTLTEEGMILRKRAEEILDLVKKTEKEVTLTNDIVMGDIYIGTGETDSIRLIARAAKKLQEACPGIRYHISSGNAPFVLEQLDKGLLDFGIVFGTVDLVKYNALKMPAADLWGVLMRKDSPLASKETIGPEDLWEEPLILSQQEERGGQLTQWLNCEASALNIAATYNLIFNASLLVEEGLGYAIGLDGIINTTGSSTLCFRPLAPKLENEMSIIWKKYQLFSKPAGKFIDVLKQYLEAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ70</accession>
    <name>F7KJ70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ORF">HMPREF0994_05902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000016">
        <property type="protein sequence ID" value="EGN31530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255678.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05902"/>
    <dbReference type="EnsemblBacteria" id="EGN31530">
        <property type="protein sequence ID" value="EGN31530"/>
        <property type="gene ID" value="HMPREF0994_05902"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6459"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN31530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="96" mass="10777" checksum="EB665E8D12ED8507" modified="2011-09-21" version="1">MLVLITYDVNTETAAGKSRLRKVAKQCVNYGTRVQNSVFECVLDPGQCLMLKAALTELIDENVDSLRFYYLGNQNKARVEHVGVNKGINVEEPLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJD8</accession>
    <name>F7KJD8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SpaA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_05967</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255743.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05967"/>
    <dbReference type="EnsemblBacteria" id="EGN31321">
        <property type="protein sequence ID" value="EGN31321"/>
        <property type="gene ID" value="HMPREF0994_05967"/>
    </dbReference>
    <dbReference type="GeneID" id="29723367"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6531"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237908_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364119" description="SpaA domain-containing protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1782"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="9">
        <location>
            <begin position="1597"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1697"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1709"/>
            <end position="1730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN31321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1808" mass="196898" checksum="7E762AA1653E9265" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJL3</accession>
    <name>F7KJL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NitT/TauT family transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255823.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06047"/>
    <dbReference type="EnsemblBacteria" id="EGN31401">
        <property type="protein sequence ID" value="EGN31401"/>
        <property type="gene ID" value="HMPREF0994_06047"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6619"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="200" mass="21926" checksum="321863DA61CB40B0" modified="2011-09-21" version="1">MPEDIRIIQLSKSYHEKKVLKELSFHIKFGAITALMAPSGAGKTTLLRILMGLEEADSGSVEGIQGMRLSAVFQEDRLCGNLSPVSNIRLTAGSHFPKQTILRALEETDLLSCASQPVRELSGGQSRRVALLRALLSPYDLLLLDEPFKGLDTDTRLRIMDYTLGSVRQAAAAGNAKTVLLVTHEEAEASYMADEIIRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJR3</accession>
    <name>F7KJR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255856.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06080"/>
    <dbReference type="EnsemblBacteria" id="EGN31434">
        <property type="protein sequence ID" value="EGN31434"/>
        <property type="gene ID" value="HMPREF0994_06080"/>
    </dbReference>
    <dbReference type="GeneID" id="29725674"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6658"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084732_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="31863" checksum="5DC8F4778EC4BDBF" modified="2011-09-21" version="1">MRIGKDMIKQAEAQFLMDCALPPESAGTRQGYLIGKKPGMPEQDFMTDVSYGYLVRECMEKAAAGLDYGIASRARVYQGMDLFFRAVLFCGKGYLLADDAIYDWCCREYQEGGVAPEWFCQFSNLRRLDRQLARFGRRIADTHIYFLPGGKEEAALPPSFEIRWYEKDELADWKEGAAFRHAICGAELMPDMIAAAAVLDGKTAAVAGASEDSPLMWQIGIDVLPAFEGKGLAAGLVTLLKQEILRRGKIPFYGTSESHGVSRNVAVRSGFLPAWAEIYVQKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK33</accession>
    <name>F7KK33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256004.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06228"/>
    <dbReference type="EnsemblBacteria" id="EGN30721">
        <property type="protein sequence ID" value="EGN30721"/>
        <property type="gene ID" value="HMPREF0994_06228"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6823"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_66_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="323"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="615" mass="71600" checksum="E7A7DE381E919DAE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK37</accession>
    <name>F7KK37_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255992.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06216"/>
    <dbReference type="EnsemblBacteria" id="EGN30709">
        <property type="protein sequence ID" value="EGN30709"/>
        <property type="gene ID" value="HMPREF0994_06216"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6808"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="117" mass="13368" checksum="6E8A5DADD3F40BD5" modified="2011-09-21" version="1">MGKEDVLAGLLMELRRGTIVLSVLSQLDEPKYGYSLVTTLTEYGMPVETNTLYPLLRRLEGQGLLISEWNTEESKPRKYYCITPEGKEVYEKLKKQWHKTAASMEQLLEGKGEEGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK69</accession>
    <name>F7KK69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN30517">
        <property type="protein sequence ID" value="EGN30517"/>
        <property type="gene ID" value="HMPREF0994_06248"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2916692_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="61" mass="7239" checksum="A6AC0D8B07A32CCC" modified="2011-09-21" version="1">MQAWEERVKDREEGFENGARDKACQTAHNLYDRGFSAEDTSRIVEESLETVRQWYQEWAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK93</accession>
    <name>F7KK93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006772915.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06272"/>
    <dbReference type="EnsemblBacteria" id="EGN30191">
        <property type="protein sequence ID" value="EGN30191"/>
        <property type="gene ID" value="HMPREF0994_06272"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6875"/>
    <dbReference type="eggNOG" id="ENOG5032SWM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207732_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="71" mass="8401" checksum="584E05D1AB45DCB2" modified="2011-09-21" version="1">MERKGDFISTTIRYKKETEVVTFQGREITLENLSPVFTPEQEAAKRRELEQQLYEVFRKYADKRQSEEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB5</accession>
    <name>F7KKB5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06294"/>
    <dbReference type="EnsemblBacteria" id="EGN30213">
        <property type="protein sequence ID" value="EGN30213"/>
        <property type="gene ID" value="HMPREF0994_06294"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6898"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363855" evidence="2">
        <location>
            <begin position="28"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="466" mass="51185" checksum="828C04C4719E5269" modified="2011-09-21" version="1">MKRKIVSAILAAVLVASSLAGCGNSGAGTKNETAEIGQNMESAEDTGTAGSVAEAEESMQDTNPEDITGTVVIWDWDGGTQQKYVDKFNEVYPNVTVEVQDVAWDDYMTKLQTSYVSGMELPDIILGEMAWRGTLFEMNICENLEEAPYYLDRNDMVPSSIPLVSDQNGNILGVEMQVTPAGFAYKRDLAVEYLGTDDPEEVGEMIKDWDAFLAVGKQVNEKSGGKVKMMVSLGDVLLSVINQNVVDYVDGANVDITEKMSRPLDITMQMRDAGIIGNVEMYSASWYSAYASDEYLFYEAGAWCPPLVIVPNDPQGEGNWAVTMPPEGSFNLGGTTLSIYKDSKNKEAAWAYLQFIYFSEQGGSYMYDLTGNYSCYQPYYSSGYSPMEKEGPVDKFFGGQSLVKYYVEEAAPNAGTVSQTKYDAIINDVFQALTPKFMSDTSIDSAKALELFKEEVALKAPDAQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKU8</accession>
    <name>F7KKU8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06477"/>
    <dbReference type="EnsemblBacteria" id="EGN47612">
        <property type="protein sequence ID" value="EGN47612"/>
        <property type="gene ID" value="HMPREF0994_06477"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7092"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_73_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="624"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="844" mass="94688" checksum="9280663C21B11F44" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKW9</accession>
    <name>F7KKW9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256260.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06498"/>
    <dbReference type="EnsemblBacteria" id="EGN47509">
        <property type="protein sequence ID" value="EGN47509"/>
        <property type="gene ID" value="HMPREF0994_06498"/>
    </dbReference>
    <dbReference type="GeneID" id="29729809"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="HTH marR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN47509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="413" mass="45242" checksum="A1D168E09B349EAE" modified="2011-09-21" version="1">MLTSRKPKNIKYHNQRLILALLRSREVMTAGELAEQAHLSVPTITKILAELQARGLVRSMGKGNSTEEGGKKPELFALNGAHRYVISITAGSERIKCALLDLTCKVLDKRSLPYTDGSSYELCMDDISALVLAACEAGKLEEKEICGIAIGFEGIVDAPRGILRFPIHNQAWGRDLPVKEELQARLPGFAGITINNGSRFAGYAELSEHPEYASCRVVTISTGTSTGGCVLENGVLMQGANGFIGELGHITVRETEEKACACGNKGCFETAVSPDALCGYMQELEKAFPREKEPAADRSGSCDYEKILRLAAKGDACARKAVEKSIDYYSILIRNIMLLYDPHIIVIQGIYTLAGDFFLKRLQELVKQSPFFHIPQGLSIVFSGLDFDRAADLGGALYSVDRYFEGEQLFEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL02</accession>
    <name>F7KL02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256293.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06531"/>
    <dbReference type="EnsemblBacteria" id="EGN47250">
        <property type="protein sequence ID" value="EGN47250"/>
        <property type="gene ID" value="HMPREF0994_06531"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7153"/>
    <dbReference type="eggNOG" id="ENOG502ZJE4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2409501_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="92" mass="10585" checksum="4C19AE85AE5A4DF6" modified="2011-09-21" version="1">MDFLQKMIPVTALILIVLFVLILIFRRLAYRRTATFKCPACGQVFRPTLMQLIFSVGSRKGQILYCPNCGEKNYLEQLENETPENDENAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL25</accession>
    <name>F7KL25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multicomponent Na+:H+ antiporter subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256316.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06554"/>
    <dbReference type="EnsemblBacteria" id="EGN47273">
        <property type="protein sequence ID" value="EGN47273"/>
        <property type="gene ID" value="HMPREF0994_06554"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7176"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="13528" checksum="7015E9E9C6D52B0A" modified="2011-09-21" version="1">MGGNLLSNYGEAIAMILFGIGFSNLLLQKNLIKKIIGLNIMDTAVYLFLAEKGYIMGRKAPIVVDGVQTVVSYINPVPSGLVLTGIVVSVSVTALMLSLTIRLYRRYHTLDLDEISARLKKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL78</accession>
    <name>F7KL78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactose/L-arabinose transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256329.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06567"/>
    <dbReference type="EnsemblBacteria" id="EGN47286">
        <property type="protein sequence ID" value="EGN47286"/>
        <property type="gene ID" value="HMPREF0994_06567"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="30627" checksum="748494CCE0902DFB" modified="2011-09-21" version="1">MKKIKLSRIIIYILLILLTVICFLPFYIMIINATHSSNELMTGLYLLPGASIFQNYLNMREMIQIGRGFLNSVIISFSSTLLSAYFGALTAFGLSKYRFKGQGIVFGIVMVSMMIPSQLGIIGFFRLCKFMGILDTFFPLILPGIANASTVFFIMQYMKSSLPDSLLESARIEGCNEFIIFNRIALPMVKPAIATMSIFNFVGSWNNFMTPMIVLFNQKNFTLPLLIMNLRGTFNRDYGATYLAIAMSIVPIMIVYAFVSRTITEGLTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLN2</accession>
    <name>F7KLN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256514.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06761"/>
    <dbReference type="EnsemblBacteria" id="EGN46353">
        <property type="protein sequence ID" value="EGN46353"/>
        <property type="gene ID" value="HMPREF0994_06761"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7387"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="71"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="411" mass="45868" checksum="75D141CAEB0CC947" modified="2011-09-21" version="1">MEQEKYLETKEEIRRELLEHMDFSRELSDEDIRDAIADRLRAREFGGRMNVYERARLGKELFYTIRGLDVLQELIEDSQVTEIMNNGLEGIFVERAGRLFPWPFGFESAEKLQDVIQQIVAGCNRVVNETSPIVDARLENGSRVNVVLGPIALNGPVVTIRRFPEEPIGMDELLAMGSVSEEACRFLEKLVRARYNIFISGGTGSGKTTFLNALAGFIPSDERLITIEDSAELQIRGIPNLVRMETRNANVEGCRPITIRDLIKTSLRMRPDRIIVGEVRGGEAVDLIGSALNCGHDGSMSTGHANSARDMLMRLETMMLMGVELPLPAIRRQIASGVDIIVHLGRLRDKTRKVLEIAEVTGFEDGEITLSPLYAFEEEEGTAGNKVMGKLVRKEELVHADKLKMAGISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLY7</accession>
    <name>F7KLY7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN45107.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360198.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN45107">
        <property type="protein sequence ID" value="EGN45107"/>
        <property type="gene ID" value="HMPREF0994_06866"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046274_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="238"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN45107.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="429" mass="48935" checksum="E524522F4C5B39FD" modified="2013-09-18" version="2">MNNKHLTFDDRLAIQAGLQQGLKVAQIAKNIGKDRATVGREIKAHRKLVATSKGNSCVRHDTCTKVPECRQGCFRGKRQCQTACGGCNSGCPEYQEEFCSGYEKSPFVCNACGNRLRCRLRRMLYDAKHAQEQYEKIRSESRRGISLTEEELVRINDTISPLIKQGQSIPAICGMYRDELPVTDRTIYSYIDAGILDARNIDLRRKLRRPERKKSGPVLRVDKKCHMGRAYGDYQAYMAQNPDAMVSQMDSVVIHKGGQAILTVLFTTCDLQLMFLRDRNTAASVTEIFKKLRVQLGGERFQALFQVILTDRGSEFTDPTRIEADTETGEIQCRVFYCEPMNSNQKSNCERNHEFIRYVIPKGQARDRYAEEEIREMMNHINSYPRKKWNGQAPIDLFKKIYGEETATLLGLEKIPSASITLTPALFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS20</accession>
    <name>S2KS20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07088"/>
    <dbReference type="EnsemblBacteria" id="EPC05239">
        <property type="protein sequence ID" value="EPC05239"/>
        <property type="gene ID" value="HMPREF0994_07088"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035711_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="416" mass="43804" checksum="66331338203DC5E6" modified="2013-09-18" version="1">MSTKEQKVKVDADYSLMPVPGHARRNIVTMFMIMLGFTFFSASMWTGQELGAGLDLSGFIGSLLLGGIILGIYTALLAYVGCKTGLSMDLLAQHSFGKKGSYLPSALISFTQIGWFGVGVAMFAIPVARLLAPDKPWMVPLLVAVAGICMTGSAFFGIRAMTIVSYISVPLIAMLGIAAMVIAVRTGDASLTEKFAESQGLSIITGAGMVIGSFVSGGTATPNFARFAKTPKAAVWTTIIAFFLGNSLMFCFGAFSGVYVGGNDIFEVMIALNLTLFAVIVLGLNIWTTNDNALYSAGLGLSNITKIKKSPLVLISGALGTITAIWLYNNFTGWLNVLNCTLPPVGAILVLGFFCHKEDYAQDKENTLEVNWFAIAGVVLGAVIANVVPVGIASINGMAVACICYLAGEAANKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSW8</accession>
    <name>S2KSW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_07005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359792.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07005"/>
    <dbReference type="EnsemblBacteria" id="EPC05337">
        <property type="protein sequence ID" value="EPC05337"/>
        <property type="gene ID" value="HMPREF0994_07005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="262" mass="29481" checksum="41AFFD38AFB1538E" modified="2013-09-18" version="1">MEEKQTNYVLMVKDLRVSYAQEEGGLFHPKKDLDVLKGVSFSIREGEVLGLVGESGCGKSTLSKALLGLIPKYEGVIVQKSLHPQMIFQDPYSSLNPVKKVGWILEEPLRLNTELNKQQRREKVLEMLKKVGLDEKQADRYPRQLSGGQRQRVCIAESLMLSPRLLIADEPVSALDVTIQAQVISLLRSIQKEMGLAILFISHDMRVVYQLSQRVMIMKDGEIVESGDVDDVYFHPEHPYTKRLLEAAGIESPGEEPARPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJR4</accession>
    <name>S2LJR4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360107.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05188">
        <property type="protein sequence ID" value="EPC05188"/>
        <property type="gene ID" value="HMPREF0994_07184"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046274_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="241"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="432" mass="49699" checksum="3D80FF59AE32328F" modified="2013-09-18" version="1">MSKFLSYEDRLIISQRIQENASFGAIAKELGKDRTTIAKEIRKYSYDKKSGRPGYPYNPCKYRNSCKAKKICGANGCTHQSAYKCSLCSECTFHCPDFEEDICSVKRKPPYVCNGCRALPRCTLLKRIYDPADAHEMAHKTISESRTGILSNESDIARINKIITPLVKNGQSLHQIYTEHVDELMCSEKTLYNYVDAQLFEIRNIDLPRKVKYRPRYKQPEFKVDRGCRLGRSYLDFQKFLEKEPETTIVQMDSVIGRPGGKCLLTVHFVETSFMLAFLRDSNTAGSVNRIFQTLDRILGAKEFNRLFPVILTDNGSEFSNPKEIEYRDTVPMRRTNVFYCDPSCPYQKGACEVNHELIRRILPKGESFDDLTQADISLMMNHINSYKRKKLNNRSPYDAFSFYYGEDLLKKLGCSPVAAENVILKPKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2H2</accession>
    <name>F7K2H2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48284.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359801.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00051"/>
    <dbReference type="EnsemblBacteria" id="EGN48284">
        <property type="protein sequence ID" value="EGN48284"/>
        <property type="gene ID" value="HMPREF0994_00051"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_101_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN48284.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="140" mass="16341" checksum="C9B125A907F1CA26" modified="2013-09-18" version="2">MIQFVLETEQQQGFSAIPCTNPDSFGARIDTSQPLTEIREGDLYFCLEEREVAVQGKKVDLSVREFNALYLLLMNRRRVMTFETIAYHVWSEEYVENELTAIHNIMSRLRQKLKISPDIPDYIISVRGVGYKFDTTQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2P2</accession>
    <name>F7K2P2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250070.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00121"/>
    <dbReference type="EnsemblBacteria" id="EGN42738">
        <property type="protein sequence ID" value="EGN42738"/>
        <property type="gene ID" value="HMPREF0994_00121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105851_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="15956" checksum="0DF6BABDB2F7B07F" modified="2011-09-21" version="1">MAERISNVTPWPENNMKNYQWLDDCLQKQPSTEKEFQPAWQAYKYLLCGKMYAYIGIDDRNGRPIVTLKLDPVFSDMLRGKYEDIVPGYYMNKLHWSTIYLDGTVPQEVLTDIVHASYKLVRSSLSKKAQQEIQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K389</accession>
    <name>F7K389_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250267.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00318"/>
    <dbReference type="EnsemblBacteria" id="EGN33459">
        <property type="protein sequence ID" value="EGN33459"/>
        <property type="gene ID" value="HMPREF0994_00318"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.342"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823183_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="342" mass="39669" checksum="DC6336E8759B8C72" modified="2011-09-21" version="1">MDYLTANEMAQIWNVSSRMVAYYCKAGKIAGAMKKGKTWLIPAHAEKPVDNRFSTNKVIVGDNPELQGELHKINRMDSENNTVYRANDIYKNLGLTRETLRYYEEIGLIEPQRNRNSQYREFTFEDVSRLMSIDFYKKRGFTPLEIKELMESGERDGITSLSRKISEIENNIRIQQRILKRLAETKGFCEYTALSSKLFTVKELPLYLVLETFDAVSSLNDYKDRVLAFMDLQEDDILSSLVRAVTFDQTGYKGTKMCLVRRAVKKVQAGEKTYLESGKCLHTVLEADSHDDSIMEKMFFAAYGWAEEHKESFKGVVYIFIRFVELSGHTERNFYEVFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Q2</accession>
    <name>F7K3Q2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ion_trans_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00481"/>
    <dbReference type="EnsemblBacteria" id="EGN48199">
        <property type="protein sequence ID" value="EGN48199"/>
        <property type="gene ID" value="HMPREF0994_00481"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656854_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="331"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="424" mass="48734" checksum="3214775C8C63F672" modified="2011-09-21" version="1">MKNCYEIKREIDVQSKKLKSDYQRAYAYHKDLFKDDYPIQNRRGKEEYSYTNATYKLEPEDYIFYKFNTWNFGASVALSSKDYIIVEGIHINYCIFENCNIENVTFRNCSFTGSKFINVRLQGVIFDKCMFSLPVMENGYHEVDDIYYAPTLFERCIFVGDFIECDIDHTLFERANFTLSNFMHVTLQYSVMDTCTLSSVQMQDCNLRNFSIRNTDIMDIEFSDERLTTVNENTLLYYSVKVKRKNANEKNDSGWIARSYDDMCLKKAQVIRRISRLFGENGYPDYEGELFYRSQIVQLKGLHGGDRLKSTLALIICGYGERPLFTLASIIITTLLFGLIYMFSGIDAGGGVIKYSLSGSTPILQVISDYGKCVFFSITTFSTVGYGNYIPLGCMSMIVSGIHMLLGVSLCALFTGCVFRKIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K442</accession>
    <name>F7K442_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250582.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00633"/>
    <dbReference type="EnsemblBacteria" id="EGN44821">
        <property type="protein sequence ID" value="EGN44821"/>
        <property type="gene ID" value="HMPREF0994_00633"/>
    </dbReference>
    <dbReference type="GeneID" id="29724178"/>
    <dbReference type="HOGENOM" id="CLU_1179006_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="235" mass="26458" checksum="7CCAE2BCA1E8D04E" modified="2011-09-21" version="1">MKKDDNKKSRMGQAMGILHITGYIVAAAAVMVFLTILCYAFVKDENLIGESAESRLQLMLYAFGWLLVLLTIILCGTWILLTFMRAFMDVIGSVFDENRKIDVRNPSFLKMLSIFLFILIAAYLVLPGERFDGWLALFENAGGLTVPLLAAAALAAGYVGVHVIYKLLEAFINKESGLKKYMDRVARIIMGMAGDLLLCLLQFVKFVPEFMNWGYDLIRADDEEEMDEEIQEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K477</accession>
    <name>F7K477_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250617.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00668"/>
    <dbReference type="EnsemblBacteria" id="EGN44856">
        <property type="protein sequence ID" value="EGN44856"/>
        <property type="gene ID" value="HMPREF0994_00668"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.724"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="34995" checksum="BA4C019B749B9044" modified="2011-09-21" version="1">MKTRKVRKKGSTIRALRRDISLWLFCVPGVVLTFIFSYIPMYGVQLAFRRYNAKAGIWGSPWVGLYYFKRFFESPYFASTIKNTLILSLYGLVVSFPIPIILALLLNSFRHKRYRKVIQTVTYAPNFISTVVMCGMIILFLSPSVGVINNVVRFFGGDPVNFMAKKEYWRHIYVWTGVWQGMGWNSVIYFAALSGISPELHEAAKCDGATKFQIIRHIDLPSILPTATILLIMNCGSILSIGFEKAYLLQNDLNLSVSEIISTYVYKVGLINNDMSYSTAIGLFNTLVNLVMLLIVNKTADKLSGNSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4A6</accession>
    <name>F7K4A6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250634.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00685"/>
    <dbReference type="EnsemblBacteria" id="EGN44034">
        <property type="protein sequence ID" value="EGN44034"/>
        <property type="gene ID" value="HMPREF0994_00685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_34_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="206" mass="24416" checksum="A580F84F7D0A8C41" modified="2011-09-21" version="1">MTTKERIVQEALNLFSIKGFKGTSVKNIADEVGIKDSSLYKHFGSKQEIFDTIVLEMKQRMSRLAERMKLPEEEDYVKSAQAYGALSLEDLLALSRNIFLFYLKDDFMSRFWRMANMEQYQNSEVYEIFRQIFMEDSIMYQAELFGEMMNQGIFVKADPVAAAMNFYTPIFFLLSKYNGREEEEEEALKILDNQVREFYRIYRCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4G5</accession>
    <name>F7K4G5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">HMPREF0994_00750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250699.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00750"/>
    <dbReference type="EnsemblBacteria" id="EGN44099">
        <property type="protein sequence ID" value="EGN44099"/>
        <property type="gene ID" value="HMPREF0994_00750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.816"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="65" mass="7475" checksum="68743428588FDC09" modified="2011-09-21" version="1">MPKMKTSRSAAKRFKVTGTGKLKRSKAYKSHILTKKSTKRKRNLRKPAITDATNVKNMKKILPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4H9</accession>
    <name>F7K4H9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="4">7.5.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60156"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.11" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250707.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00758"/>
    <dbReference type="EnsemblBacteria" id="EGN43467">
        <property type="protein sequence ID" value="EGN43467"/>
        <property type="gene ID" value="HMPREF0994_00758"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.823"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043211">
        <property type="term" value="F:ABC-type carbohydrate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015862">
        <property type="entry name" value="ABC_transpr_MglA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF7">
        <property type="entry name" value="PTHR43790:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="252"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN43467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="502" mass="55975" checksum="0C5BEB5A8AF5167B" modified="2011-09-21" version="1">MADKKDDIVLSIRGMSKSFGRNRVLDRISMDVKSGTVMGLMGENGAGKSTMMKCLFGTYQKDEGTIFLNGKEVSFSGPKDALENGIAMVHQELNQCLERNVVDNLFLGRYPVNSMGIVDEGRMKKEASDLFRKLGMTVNLTQPMRNMSVSQRQMCEIAKAISYNSRVIVLDEPTSSLTVQEVDKLFEMMRMLKKQGIALIYISHKMDEIFEICDEISVLRDGNLVMTKSTSDANMNELIAAMVGRSLDNRFPPVDNVPKGVILSIQNLSTKFEPHLQDVSFDVREGEIFGLYGLVGAGRTELLETIFGVRTRAAGRVYFNNRLMNFNSAREAMEHGFAMITEERKANGLFLKGDLTFNTTIANLEQYKTGVALSDAKMIKATGNEIKIMHTKCMGPDDMISSLSGGNQQKVIFGKWLERGPRVFMMDEPTRGIDVGAKYEIYELIINMAKQGKTIIVVSSEMPEILGITNRIGVMSNGRLSGIVNTKETNQEELLRLSAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4I1</accession>
    <name>F7K4I1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250709.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00760"/>
    <dbReference type="EnsemblBacteria" id="EGN43469">
        <property type="protein sequence ID" value="EGN43469"/>
        <property type="gene ID" value="HMPREF0994_00760"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330E2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159977_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="103" mass="11286" checksum="F5C65B2C47F8D7F8" modified="2011-09-21" version="1">MAELKCGVNNCTYNNDRCCCKGDIMVGGKSAQQEDDTCCDSFKQRSGDSTSNSMNPCRTISIDCEAVKCVFNTNYKCYAEHVDIKGCGACDCRETACATFKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4S3</accession>
    <name>F7K4S3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250801.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00852"/>
    <dbReference type="EnsemblBacteria" id="EGN43404">
        <property type="protein sequence ID" value="EGN43404"/>
        <property type="gene ID" value="HMPREF0994_00852"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.929"/>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="436" mass="47422" checksum="ED42188953E5F50B" modified="2011-09-21" version="1">MGTKTERKFRFETLQLHVGQEQADPATDARAVPIYQTSSYVFHDCQDAADRFALSAGGNIYGRLTNPTEDIFERRMAALEGGSAALAVASGAAAIAYTFQNLAHQGDHIVAARNIYGGTYNFLAHTFPDFGVTTTFVDPFDEKELEGAIRENTKAVFLETLGNPNSDVVDIEGIARIAHAHKIPLVVDNTFATPYLVQPIAYGADIVVHSATKFIGGHGTAVGGVIVEGGSFDWEASGRFPSLTEPNESYHGVSFTEAAGPAAFVTKIRAILLRDTGATLSPFHAFLFLQGLETLSLRVERHVSNALKVASYLASHPQVEKVHHPSVTENASQKALYSRYFPNGGGSIFTFEIKGDDRTAKKFIDHLQLFSLLANVADVKSLVIHPASTTHGQLNEEELRQQGIRPNTIRLSVGTEHIDDILQDLEEAFRAVAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Y3</accession>
    <name>F7K4Y3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LytR_cpsA_psr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250861.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00912"/>
    <dbReference type="EnsemblBacteria" id="EGN43221">
        <property type="protein sequence ID" value="EGN43221"/>
        <property type="gene ID" value="HMPREF0994_00912"/>
    </dbReference>
    <dbReference type="GeneID" id="29724006"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.997"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554106_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="247"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="492" mass="56743" checksum="A176529EC325ACCF" modified="2011-09-21" version="1">MSRENGNEMEQIQKNLERFLDREVEKYEKGEAGYRDDVDMDEAEYEEESLYEAEYDEESEYGDEEEYDGEPEYEDEEEYDEEPEYDDEGEYDGEPEYEDEREDDEPEYDEELYDEEEEPLYEEERYGGRRPGRRRYDEPEHAVRKDKGREKPKKEKRKREEDKHAVMSRDKKKNGKKKKSRGKKVLAVLAVLLVLFGAVWYLAIGSIYGKMRYSRVETLAGEPLKENGVVNILLIGSDSRTEGDDGRSDAMILLSVSSKTRTIHMTSLLRDMYVDIPGRDGNRLNAAYSFGGPELLLETVKQNLGIEVNRYAVVNFQAFANLVDAVNGVDLELTNEEVKWVNAYLNEYNELRGMPMETDYLDTSLSGMIHLNGAQSLAYSRNRFIGTDFGRTERQRKVLSAVMKKLPAALVTNPNGLINGLFPNLTTNLTQMECLRLSLIGGKLLTYDIVQESIPLEGTYSSVTIRGMDVLQVDFDRNRAYLQEQLYGKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5A9</accession>
    <name>F7K5A9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250987.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01038"/>
    <dbReference type="EnsemblBacteria" id="EGN43011">
        <property type="protein sequence ID" value="EGN43011"/>
        <property type="gene ID" value="HMPREF0994_01038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844098_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="226"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="329" mass="37192" checksum="81A18BD883EDF638" modified="2011-09-21" version="1">MDRQMGEILRKQEQQEQKAYRSAEMLVDMMRSDFVNSTEVLSMLDQNAAHLPELFRLTDAPVWPFDGKSIPIRRSEQFAAAKHTLCQIPYFHSHDGCELIYVFRGCCKQRFIPADTTLVLREKQACLVHPGAIHAIERCHEQDIILKFMIPSSFFEETGSPAVSIPGTPVTVFDRCSPKVDFYMQTLLVEACTRCAFWQQAVHSYLILLFIELTRRQAEPPGELSARLNSYLSSHLRDATLSGFAASIGYSADHAGRLLRMETGKNFSHAAAAVKMQAAAELLARTDDPIETIAYTLGYTSPSGLYKQFERIYGMPPGSYRKLWNHQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5I5</accession>
    <name>F7K5I5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01114"/>
    <dbReference type="EnsemblBacteria" id="EGN42876">
        <property type="protein sequence ID" value="EGN42876"/>
        <property type="gene ID" value="HMPREF0994_01114"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1223"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541541_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357099" evidence="1">
        <location>
            <begin position="33"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="466" mass="49808" checksum="FD79B78D0581027B" modified="2011-09-21" version="1">MTRVSKKFLAVLLSSAMLTAMTGCSSSTSADSATPSAPAAESAASAASADGAAAETTATSSGAELSGKLDIWAWGADDEAKAREGALEIFISEHPELDITYTIIPTADSVWDQKAAAALSSGSAGDVMQMSPDYYGMNTEYYIDLNPYVEAEGVNLDDVLVPGVIDGYYDSDGKLEGFPLLANCFVMAYNKDMFDAAGVAYPEDGWTLEDLADWGQAFATGEGANKTYALVKHWVMNNVMVYSCGGTPYSDDLTTSHMGTPEIVDALTLYKKMIDTGVMPDDTAQDTIPAETLFVSGKSAMYPCGGFETITVTNDSDENGINIGFCSMPSDKNGNEINVQYATGWAITTTSKNPDAGWQFLKESAYANDEMAKQTAICGMPSNKKVAESYYADLSFKGEGLDNSYYVEHMGNTHLNPFGGTLASTGNIWTTMVEAVLLDNQDPQAVVDQYAPQIEKEFAGYSFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5P2</accession>
    <name>F7K5P2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42918.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359959.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01156"/>
    <dbReference type="EnsemblBacteria" id="EGN42918">
        <property type="protein sequence ID" value="EGN42918"/>
        <property type="gene ID" value="HMPREF0994_01156"/>
    </dbReference>
    <dbReference type="GeneID" id="29725274"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42918.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="325" mass="38379" checksum="15454C6A026F9D45" modified="2013-09-18" version="2">MDLISIIVPVYNMRTLLRRCLNSILNQSYYNLEIILINDESTDGSGSICEEYCRKDNRITVIHKKNGGLSAARNTGINLAKGKYIAFIDSDDFVHKDYIKILYNFIVEFHADIAICDYEIGNGNVLHSYDNDDLFYVTTSENLLKTWHYKNKKIETVVWNKLYKRELFNNIRFPEGYSFEDIHVSHVLIAAASKVVIVKRKLYYYYQRSNSIIHTITKAKIQEGFYAQNVRIQYFKDHGYENVVKRLNVKKLKFCIRNYFIIQSSELKEYKNTILQLYQDLYKEVKGYSDLSFIDKTLLYIFHRGNKIGNIFFHMLGTIHIWHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5R9</accession>
    <name>F7K5R9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251147.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01198"/>
    <dbReference type="EnsemblBacteria" id="EGN42599">
        <property type="protein sequence ID" value="EGN42599"/>
        <property type="gene ID" value="HMPREF0994_01198"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1311"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="611" mass="70278" checksum="63569B599BBFA9AC" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5U7</accession>
    <name>F7K5U7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN42552">
        <property type="protein sequence ID" value="EGN42552"/>
        <property type="gene ID" value="HMPREF0994_01226"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1339"/>
    <dbReference type="eggNOG" id="ENOG5033AS3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2450791_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="89" mass="9832" checksum="8088D2D17D57FF26" modified="2011-09-21" version="1">MDYYDTENDSPDLAEIIMSRISSQLSTHNWSLKILSDNSGVPYETIKKIANGKISNPSLKSILKISLAFGCTIDYLAGKEISPRPSDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K612</accession>
    <name>F7K612_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251240.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01291"/>
    <dbReference type="EnsemblBacteria" id="EGN42323">
        <property type="protein sequence ID" value="EGN42323"/>
        <property type="gene ID" value="HMPREF0994_01291"/>
    </dbReference>
    <dbReference type="GeneID" id="29726139"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1410"/>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019444_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="65"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="698" mass="80680" checksum="D75842CBF8293B00" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K641</accession>
    <name>F7K641_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42182.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359975.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01320"/>
    <dbReference type="EnsemblBacteria" id="EGN42182">
        <property type="protein sequence ID" value="EGN42182"/>
        <property type="gene ID" value="HMPREF0994_01320"/>
    </dbReference>
    <dbReference type="GeneID" id="29726294"/>
    <dbReference type="eggNOG" id="ENOG5032T59">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034627_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045691">
        <property type="entry name" value="DUF6056"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19528">
        <property type="entry name" value="DUF6056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42182.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="492" mass="56310" checksum="3A0BE5CF88E860B7" modified="2013-09-18" version="2">MKNKMTEKWIAGFLTIIFILALIPVLIIAKYNYPCADDFGFSVYSHIAWEETHSIFQVFAGALKTVKERWFGWQGTFSSIFVMSLQPAVFGEAGYRWVPWIMIGAISFSTLFFLYVILKKLMEVRTPVYLAISMIYLIFALECMIDKTQGFFWFNGAAHYIIPHSVAVILIGLMICIIKNDRHKSVKMMLACLAAFFVGGGNYISALIIAILFAVALIVAVYTRKRKCIRLVILPCIFFLTAFLINVCAPGNSIRQGEVGYRPSVVNSVILSFYYCVEYIMERWFDWTYIILVFSLLPFLWEVVKTVGNKFNYRFPLLVPLGSFCFLSAMFTPSLYAMGVAGGGRIFNIIFLDYLFLIILNIYYFLGWIYRHCGLGENKVSCVESSNIKIYLLVLLCVTIFIGGLYSEVNPDYFTSTSAIKSLVSGEAADYGAETAKRTIQLQNNRQKSIQLEIFKTKPYLLYYSDIEIDADDWKNNSMERYYRIDEIQGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6D2</accession>
    <name>F7K6D2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251386.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01437"/>
    <dbReference type="EnsemblBacteria" id="EGN41911">
        <property type="protein sequence ID" value="EGN41911"/>
        <property type="gene ID" value="HMPREF0994_01437"/>
    </dbReference>
    <dbReference type="GeneID" id="29726656"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1565"/>
    <dbReference type="eggNOG" id="ENOG5031X8H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025183_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046062">
        <property type="entry name" value="DUF6020"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19484">
        <property type="entry name" value="DUF6020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="612" mass="70119" checksum="26D70D6D6FBA4127" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6D7</accession>
    <name>F7K6D7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01442"/>
    <dbReference type="EnsemblBacteria" id="EGN41916">
        <property type="protein sequence ID" value="EGN41916"/>
        <property type="gene ID" value="HMPREF0994_01442"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1570"/>
    <dbReference type="eggNOG" id="ENOG502ZUGM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453290_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="572" mass="64777" checksum="2FB13FED2C0758A6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6M0</accession>
    <name>F7K6M0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaK</name>
        <name evidence="13" type="ORF">HMPREF0994_01530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="9">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251479.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01530"/>
    <dbReference type="EnsemblBacteria" id="EGN42004">
        <property type="protein sequence ID" value="EGN42004"/>
        <property type="gene ID" value="HMPREF0994_01530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1668"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN42004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="624" mass="66371" checksum="4BA91CF0DEF3ED01" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6N9</accession>
    <name>F7K6N9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThiF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251498.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01549"/>
    <dbReference type="EnsemblBacteria" id="EGN42023">
        <property type="protein sequence ID" value="EGN42023"/>
        <property type="gene ID" value="HMPREF0994_01549"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1690"/>
    <dbReference type="eggNOG" id="COG1179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="26411" checksum="EBC1FDD0782001D9" modified="2011-09-21" version="1">MQEQFVRTALLLGEEGIDKLSRSKVAVFGIGGVGGFTVEALARSGVGYFLLVDNDKVALSNLNRQIIATLDTVGRYKTQVMKERILSINPQAAVETRECFFLPENADEFDFSSYSYVVDAVDTVTAKLELVVRAKEAGVPVISSMGAGNKLDPTRFEVTDIYQTSVCPLARVMRRELKARGIQDLKVVYSREEAQKPEKSLMTEEDSASRRRSVPGSVSFVPSVAGLIAAGEVIRDLIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Q4</accession>
    <name>F7K6Q4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251513.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01564"/>
    <dbReference type="EnsemblBacteria" id="EGN42038">
        <property type="protein sequence ID" value="EGN42038"/>
        <property type="gene ID" value="HMPREF0994_01564"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1708"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070012_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="34042" checksum="7F8840192DEAC39E" modified="2011-09-21" version="1">MEKSIQVGNIVIRRSNVLEKEEKDQISRLTAVCNRADGTCNELFLTNEFNVYPEMPCFFRAYVENGSTEPGLAGILIIYGDQEKMAEISAYVLPEQRGKGVFHALFHTALEYIRFFGYSELEFKTEKAYPAAGDILKKYGAVLIRKEYLMIWREKEEAAKGSGSPSVVRQARKGDLDIMTEIQAEAFGDTPEMARRYVESSYQSSDTMLFVIETQGRCTGCCCVDTSGERAMIFGLCVAADFRGKGLGGQLLRESVKIAADKKGEVSLCVEAENKNALHLYETCGFREATEYRYFGCPVAVIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7J1</accession>
    <name>F7K7J1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251733.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01820"/>
    <dbReference type="EnsemblBacteria" id="EGN41633">
        <property type="protein sequence ID" value="EGN41633"/>
        <property type="gene ID" value="HMPREF0994_01820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1990"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="276" mass="30864" checksum="F9BB1B73E185B22A" modified="2011-09-21" version="1">MNNEKMGNFISEMRKSQNLTQKELAAKLEITDKAISKWERGISCPDISLLIPLAQILGVTTSELLNGEKCAAPEKSKDVLVEETLLYSDRSAAQKVDRVKGILFTCFSSSVILAAVICFICDFCITGQLTWSLLTASSLLFSWILLLPLFKARKNIIRKSLLVLTLTVIPYLAVLSRLLSLPAIYKMGAVIAIISLLGLWCIYIPFLKIPHRKLYVTGILLLVIIPIMWGINGTVSFFIQQPLDPSTKFVDSLTTLVLLIIAAFCFSKEFFRNRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7U9</accession>
    <name>F7K7U9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251908.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01995"/>
    <dbReference type="EnsemblBacteria" id="EGN41400">
        <property type="protein sequence ID" value="EGN41400"/>
        <property type="gene ID" value="HMPREF0994_01995"/>
    </dbReference>
    <dbReference type="GeneID" id="29728100"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2191"/>
    <dbReference type="eggNOG" id="ENOG5033HGC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_623732_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="2">
        <location>
            <begin position="377"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="439" mass="48555" checksum="472BC778936EC1A7" modified="2011-09-21" version="1">MENKRLRYSMQILEVVMNFLVIFCLETVVFSSFSNLEGLVGETGTLVKTPGILRQLLFLAVPLLFLLIREKAGHFLTFVACHAVLAAAAVFLLGDGVMQRVVFGVLAAGYLVRSFQLRISRQEVGEGQLGPVAGGIAAGGSFLLCAYLGQETACGRIVNTALIYTFFYFVYAYLEHLVQFVKFNRSSNAHIPVRKMLVQGGGLAAVFGVIAVCILGAGTNNRLVRGMMDLVKTAAYYIARAIAVCISFLLNLFSGKEGEMIEEGAAAGQMDMGLSEAAATPAWLDILIKITEYLMAALTIALICFLLYRLVLAAVKKFYEKGIVQDEEEGQATEIRESLDRKRKKKEKEKPFPFLTRTPEQKIRKYFIRTVRKLGAPEDCRTARELLETVPAPEPEKEKAVDELLRLYEKARYYGNCSKEEAELAVHAADTIAGKKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7V9</accession>
    <name>F7K7V9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">HMPREF0994_02005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251918.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02005"/>
    <dbReference type="EnsemblBacteria" id="EGN41410">
        <property type="protein sequence ID" value="EGN41410"/>
        <property type="gene ID" value="HMPREF0994_02005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2201"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN41410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="238" mass="26446" checksum="3D11C07DEF57AC15" modified="2011-09-21" version="1">MNGILLSADSEVDFMIHGIFSYSFFGHKVWITTTHVCLLIIMLVLIGFAIAANRAMKRASEVPGFFQNIVEMVVEKLDGMINNVMGKKAVKFANYIGTIFIFILICNISGLFGLRPPTADYGVTLPLGLLTFTLIFFNKLKYQKVSGFLKGLCEPWPIWAPINIIGDVAVPISLSLRLFANVLSGTVMMALVYGLLKWFAVIWPAALHVYFDLFSGAIQTYVFCMLTMTYISDAIGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K894</accession>
    <name>F7K894_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">sn-glycerol 3-phosphate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251780.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01867"/>
    <dbReference type="EnsemblBacteria" id="EGN41272">
        <property type="protein sequence ID" value="EGN41272"/>
        <property type="gene ID" value="HMPREF0994_01867"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2046"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043127_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356715" evidence="1">
        <location>
            <begin position="34"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="492" mass="54635" checksum="CC84B3EB3851FF76" modified="2011-09-21" version="1">MKNLSGKKKRFWVLVCVAAVAAAMLLGGCGSKNKVKLDPDNPVTITIWHYYNGAQQTAFDSLVKEFNDTVGMKEGIFVKSTGKGDVNQLEESVRSALKKEVGSDEAPDIFSSYADTAYEIQQMGYLADLSSYLTEDEISEYVDSYVEEGRIGKGNQLFIFPTAKSSEILMLDKTDWDKFAAATGAELSSLSTMEGLAETAKEYYEWTDSLTPAVENDGKAFYGRDAMANLFIIGSMQLGTEIFKVKDQQVTLQVDRDVMKRIWDTWYVPYVKGYFSSYGRFRSDDVKIGEIISYTGSTTSAMYFPDEVELEDETYPIDYIILPAAVFEGGEAYAVQQGAGMVVTASDRQREYACTEFLKWFTQSENNLVFGCASGYLPVKKDANSKEVLDKVIQEKDLDVVPKTFDTLIAAFDTVNSSIMYTNKAFQGGAAARKVLEYDLSDKAAADRAAVVESLNAGMSLEEAAAEFISEEAFDQWFTGFERKLQEAVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8C7</accession>
    <name>F7K8C7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251816.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01903"/>
    <dbReference type="EnsemblBacteria" id="EGN41308">
        <property type="protein sequence ID" value="EGN41308"/>
        <property type="gene ID" value="HMPREF0994_01903"/>
    </dbReference>
    <dbReference type="GeneID" id="29727679"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2086"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="279" mass="30796" checksum="5960DF77F924A6A6" modified="2011-09-21" version="1">MNKKKMKQVVFETIGVLISFLVLIPFLMVFLNSMKSKRQANLLQLSLTGISWEQFLENYGTVIREARLVSSFLNSAVVTFLGAALVLSCASMAAFVVVRRKTRAMKAVNNFIVMGLTLPLAMVPVYFMLSKVHMTTGTGAVAGAILVYAASIFPFIFFIYTGFIKGISSEIDEAAIIDGASPLLMYFRIIFPLLKPVTITALMHCVMSIWNDFGISLYLLNSAKRTTAVLTTYLFMGQKASDWQLLFADVVLVSMPIVILYLFMQKYIVAGLADGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8J1</accession>
    <name>F7K8J1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide/nickel transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02176"/>
    <dbReference type="EnsemblBacteria" id="EGN41083">
        <property type="protein sequence ID" value="EGN41083"/>
        <property type="gene ID" value="HMPREF0994_02176"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2381"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363575" evidence="6">
        <location>
            <begin position="32"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="91"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="34037" checksum="5C17D91F2721EF7C" modified="2011-09-21" version="1">MIKKLISMAATLLVVSFLVFLAFAVIPGDPATSKLGTEATPARVEALREEMGLNRPLPVRYASWLAGMFRGDLGTSYSYSMPVTDMVAEKIPVTLTLTLMAFAMMVLISIPLGLYTAKHEGGTADHVVSVLNQIIMAIPPFFSGILITLLFGLLLHLFTPGGYVSYTKSIAGFIGYLFFPALSIALPKAAMAVKLLRSSIIQEMSQDYARTAYSRGNSTRDVMYRHLLKNAMIPVVTFLGMALTDMIAGSIIIEQVFNIPGLGRILLTSISNRDYPVVEAIIVLLAFLVIFINFLVDFIYKKIDPRIRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8N9</accession>
    <name>F7K8N9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252129.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02228"/>
    <dbReference type="EnsemblBacteria" id="EGN41135">
        <property type="protein sequence ID" value="EGN41135"/>
        <property type="gene ID" value="HMPREF0994_02228"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2433"/>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007352_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="115"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="513"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="822" mass="91302" checksum="C0A1DC6159D809DA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8T6</accession>
    <name>F7K8T6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252192.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02291"/>
    <dbReference type="EnsemblBacteria" id="EGN41198">
        <property type="protein sequence ID" value="EGN41198"/>
        <property type="gene ID" value="HMPREF0994_02291"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50327JJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2409500_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="92" mass="10556" checksum="9BC1CCBCA4FF1DEC" modified="2011-09-21" version="1">MDNIKYKTFEDVTEVYGKTNLCKICNIKQIITYAKLGVQPVWIDEGYGGKLIAYYFIPETKVAWKYWLENRPDTGQAKNAADRGGNRSAGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K910</accession>
    <name>F7K910_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_02339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252240.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02339"/>
    <dbReference type="EnsemblBacteria" id="EGN40996">
        <property type="protein sequence ID" value="EGN40996"/>
        <property type="gene ID" value="HMPREF0994_02339"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2559"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
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</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K924</accession>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
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    <dbReference type="EnsemblBacteria" id="EGN40761">
        <property type="protein sequence ID" value="EGN40761"/>
        <property type="gene ID" value="HMPREF0994_02362"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|658086.3.peg.2585"/>
    <dbReference type="eggNOG" id="COG5617">
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    <dbReference type="HOGENOM" id="CLU_344101_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="21"/>
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        <location>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="748" mass="84503" checksum="CB82C163C45DC90D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K937</accession>
    <name>F7K937_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02375</name>
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    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
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    <dbReference type="STRING" id="658086.HMPREF0994_02375"/>
    <dbReference type="EnsemblBacteria" id="EGN40774">
        <property type="protein sequence ID" value="EGN40774"/>
        <property type="gene ID" value="HMPREF0994_02375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2598"/>
    <dbReference type="eggNOG" id="COG2035">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DUF368"/>
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        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="36"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="30065" checksum="3E5DFD72DFCA998D" modified="2011-09-21" version="1">MQEKKDSSISVMLKGICVGGTMLVPGCSGGSMAMILGVYDRLVSSVSSFMKHKKESLFFLTLFCLGGGLGMILFARPMLSLMERFEMPMLYFFIGAIAGSVPMILKKASWEKGGLGKLLFFLAGAAAVGLFALLPSDTFQVDMSAGLTSYLLLILAGVIAAIALVLPGISVSYMLLLMGMYDTVMRAITEMYLPYLIPIGLGLALGVVATTKLLEKAMEKFPGPSYLCILGFMAASMAQVFPGLPSGGDWLVCPLMLAAGFLLIRFLAEGEIRRSLQTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K956</accession>
    <name>F7K956_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252297.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02396"/>
    <dbReference type="EnsemblBacteria" id="EGN40795">
        <property type="protein sequence ID" value="EGN40795"/>
        <property type="gene ID" value="HMPREF0994_02396"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2625"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="33517" checksum="41F7B224A6ECACBC" modified="2011-09-21" version="1">MLLKWKNNKSDYIFTFIVYASVVLISLLILYPLLFVVIASVSDPDLVASGQVLFWPKGITLEGYRYIFRDQRIWSGYYNTIRYTFFGTLIALTITIPAGYALSRTDMAGRGFVMKLLIVTKYFSGGLIPTYLVVKGLHLVNTPYVLMILGSFSVFNLILCRTFFMNTMPLELQEAAEIDGCSIFQYFIKIVLPLSKSIIAIMVLYYAVGHWNSFFNGLIYVSDAKLYPLQLILRDILISGQSVDPSVSDPEAIELMKQIARTIKYGVIIVSSLPVLILYPFVQKHFVKGVMIGSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9B8</accession>
    <name>F7K9B8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252369.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02468"/>
    <dbReference type="EnsemblBacteria" id="EGN40867">
        <property type="protein sequence ID" value="EGN40867"/>
        <property type="gene ID" value="HMPREF0994_02468"/>
    </dbReference>
    <dbReference type="GeneID" id="29726674"/>
    <dbReference type="eggNOG" id="ENOG50332MI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125862_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024265">
        <property type="entry name" value="DUF3788"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12663">
        <property type="entry name" value="DUF3788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="139" mass="16085" checksum="243CFFD365693DCA" modified="2011-09-21" version="1">MAKSIYLEKAMLSDELTLAVEVSGYKQQWDEIIRYLAETYVDFSQEWKYYGKAWGWTLMLKSKSKTLCYITPAQEYFQVSVIFNDKGRALAAAYDLPETVLQAVEASKSNPKNIPYDFDIRTNTDTDIAKRLIEIRSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9K4</accession>
    <name>F7K9K4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NERD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252472.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02571"/>
    <dbReference type="EnsemblBacteria" id="EGN40970">
        <property type="protein sequence ID" value="EGN40970"/>
        <property type="gene ID" value="HMPREF0994_02571"/>
    </dbReference>
    <dbReference type="GeneID" id="29725716"/>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198118_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="1">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="25134" checksum="A9154F5254850480" modified="2011-09-21" version="1">MISILFLILIFIWFYKKRTSYNPYDISLSHSSYYECAFCREEKCTEEVLRILEPVAGHKRILKNVFLQGEKDGRAGADVVMIHESGIYVIHSANLEGVIAGNPQGRYWKQTFREGWLLACRNYLYNPFLENKKILDVMQWEFRDMPWLPYYSFAVFGNRGVLLTSGWMGENCFSLPVHALSSVVADVFRYNRRFLKEQDIERIYERMKNTLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9S8</accession>
    <name>F7K9S8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252512.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02611"/>
    <dbReference type="EnsemblBacteria" id="EGN40594">
        <property type="protein sequence ID" value="EGN40594"/>
        <property type="gene ID" value="HMPREF0994_02611"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2862"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="30947" checksum="9BA9AD7ED094DC41" modified="2011-09-21" version="1">MGLVRVRDILKMADENRFAAAAIDVFDFQSAEWVVKAAEREQVPVLLMFYPDMSSFIPFSTMAGIAVDLAKQASVPVGVHLDHGKSYDVAVGGIAAGFPSIMYDGSARPFEENLEVTASVVKCAHILGIDVEAELGTVGQGSRKEDFCNEELYTKPEMAKDFVERTHVDSLAVAIGNSHGHYVCEPHLDIRRLDEINKTIDVPLVLHGGSGIPAEQMIESVKYGINKVNIGTEFFEKCKNCVAAHMGEDGFILDHYKEAGEEVIEFVRGRIARINPYHFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Z7</accession>
    <name>F7K9Z7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252581.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02680"/>
    <dbReference type="EnsemblBacteria" id="EGN40663">
        <property type="protein sequence ID" value="EGN40663"/>
        <property type="gene ID" value="HMPREF0994_02680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2934"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356756" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="395"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="528" mass="57940" checksum="13DDD906D7E26A5F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAJ2</accession>
    <name>F7KAJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252719.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02818"/>
    <dbReference type="EnsemblBacteria" id="EGN40427">
        <property type="protein sequence ID" value="EGN40427"/>
        <property type="gene ID" value="HMPREF0994_02818"/>
    </dbReference>
    <dbReference type="GeneID" id="29724972"/>
    <dbReference type="eggNOG" id="ENOG5030FJA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281357_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="206" mass="22093" checksum="85B3B0869BB3AB6A" modified="2011-09-21" version="1">MEIDKYVRNAGIWGSRKSLTAVLLGILLLAAACLGGCGNSQDMFVRIPEETLPADQESSQAGSPETGKEPGTTEASETEPSEEMIQESENLPQKETNIPAASGTQELNGSIQSVGSYGFTVYQIFNEQQEDGGMIAYSSKEKNTLVDVSFTERTVFTVTSSSDGGITSSSAPGTKADLEVSRSTYMTGMWEGNIFIADTVTIYHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB75</accession>
    <name>F7KB75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl diphosphate synthase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40291.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360262.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03114"/>
    <dbReference type="EnsemblBacteria" id="EGN40291">
        <property type="protein sequence ID" value="EGN40291"/>
        <property type="gene ID" value="HMPREF0994_03114"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40291.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="34138" checksum="4B9392F2800B8F06" modified="2013-09-18" version="2">MNFEEVRQEKVEEIEKILKKYLPAEVGYQKTVLEAMNYSVLAGGKRLRPMLMQETFRMFGGEGHLVEPFMAAMEMIHTYSLVHDDLPCMDNDEYRRGRKTTHAVYGEGMAVLAGDALLNYAFETACRSFAMAEEELGVLPRCAKAMTILAQKAGIYGMIGGQTADTEAEELPEEKVTQELLLYIHENKTAALIQSSMMIGAVLAGASDEQLQRLEKIGTCIGLAFQIQDDILDITSSLEVLGKQTGSDLKNHKVTYVSLNGMEHSVKEVRRLSEEAISGLSSIACEKGGAGRNEFLEILVDDLITRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB81</accession>
    <name>F7KB81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antibiotic transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252975.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03074"/>
    <dbReference type="EnsemblBacteria" id="EGN40251">
        <property type="protein sequence ID" value="EGN40251"/>
        <property type="gene ID" value="HMPREF0994_03074"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3359"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101327_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="238" mass="25667" checksum="B329D9842A6A9CDE" modified="2011-09-21" version="1">MSAFLYGAALQWKLDIRSKALLITCYLVPLLFFAVMGGIFTSLMPEAKSTLIQSMTVMGVSMGALVGLPPSLTEIYGSDIKKVYKANGVPLYLGLFTISLSAFLHLMLMCLIIYIAAPIAFDAQLPERPLWYFIRLSIFIGVSLSLGSILGLSVKNQSKLTMVSQIAFLPSIMLSGIMFPAGLLPRPLAVIGSIFPAAWGYRLLTGDGSVCSSLFPLAVIFAVCAAICVLALRRLQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBC4</accession>
    <name>F7KBC4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253056.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03155"/>
    <dbReference type="EnsemblBacteria" id="EGN39985">
        <property type="protein sequence ID" value="EGN39985"/>
        <property type="gene ID" value="HMPREF0994_03155"/>
    </dbReference>
    <dbReference type="GeneID" id="29728974"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="34364" checksum="1F09C089FA1969D4" modified="2011-09-21" version="1">MKRKKSGNLTIQQRDNIWGYAFILPCVIIFAIFTIYPFCYSAFLSMQEKVGTNITDLQFAGAKQFIKAFQSKEMWNSFKVTAIYTFPTVFFHLAIGLLLAVLVNKSIHLKGMVRAMYFVPVILSSVVISMVWKFMLSPKVGLFNLFLAKFGIDPDIAWLKSPKLAMIAVIIVGVWKWIGYFMVLYLAALQDIPVTLYEAAEIDGANGVKKFFKITFPLLGNTTQFLMIISIINTFQVFDQIFMMTGGGPIKRTDVIVYYIYRQAFQIYDMPYASAVSWLLFAVIFVLTALQMKISKNKVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBG5</accession>
    <name>F7KBG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40029.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03199"/>
    <dbReference type="EnsemblBacteria" id="EGN40029">
        <property type="protein sequence ID" value="EGN40029"/>
        <property type="gene ID" value="HMPREF0994_03199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40029.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="33073" checksum="E9C4D269E32748F3" modified="2013-09-18" version="2">MDKQFQIISDSSCDLPPELAMEKNIRVVPFYVSFDDKTYLKEVEEVGVREFYQRMVDNPGVYPKSSLPGIQDYYDAFEPYAKEGIPVFCICITTKFSGSMQSALSARGLILEKYPRAQIRVMDATVNTVLQGLLVLEAAAMQESGAGYEETIARMEEIKGTGRIFFTVGSMEYLKAGGRIGKVAGVAGALLGIKPVITLKQGEIFPSGIGRVRRKTMQKTVDLLLDYLRERGDDIGNYSIVIGYGYDRAEAESYRDMVMERLSVNYNIGGLPIYQIGATIGVHTGPYPLGLGILEKAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBH9</accession>
    <name>F7KBH9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_03213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253114.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03213"/>
    <dbReference type="EnsemblBacteria" id="EGN40043">
        <property type="protein sequence ID" value="EGN40043"/>
        <property type="gene ID" value="HMPREF0994_03213"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3511"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="406" mass="45443" checksum="35FFB46CF7B0F1E4" modified="2011-09-21" version="1">MQRSGESGRRSLGIYLHVPFCVRKCLYCDFLSAPGDDEMKTEYVEALKREIRGQASLYGGHEVRTVFFGGGTPSLLSGEQIGVIMDCLREEFSFGGDGVEVTMEVNPGTVTRESLSGYRLAGVNRLSMGLQSADDRELKALGRIHTWEDFLCSYEMARKEGFGNINVDLMSALPGQSPEGWAETLVKVIRLKPEHISAYSLIIEEGTPFFEYYGKSGDGAEAGRLPLPTEDEDRVMYGRTKEILGKAGYGRYEISNYALPGFACRHNVSYWERIDYAGFGVGAASLLGNVRWSNTADMGRYLEFSGERGMETHLKLSVQKLSVQEQMEEFMFLGLRMADGVSARRFYEEFGESLENIYAAAIDKLVREGLLVRVEKGADGRDDTWYRLTDFGIDVSNYALSEFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBI9</accession>
    <name>F7KBI9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253126.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03225"/>
    <dbReference type="EnsemblBacteria" id="EGN40055">
        <property type="protein sequence ID" value="EGN40055"/>
        <property type="gene ID" value="HMPREF0994_03225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3524"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="121" mass="13883" checksum="D00C0B5E03074955" modified="2011-09-21" version="1">MNCTIRSLYLCVKDMDRAIRFYESFLEQPVTGRDELYSVFDVNGFRLGLFAYEKAGEDHTYGSNCLPSLEVDCLDILKKKLEGLPVFFECKRIGNNWVSEFEDSEGNHIELTAPVKEGDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBR7</accession>
    <name>F7KBR7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="7" type="ORF">HMPREF0994_03308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253209.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03308"/>
    <dbReference type="EnsemblBacteria" id="EGN40138">
        <property type="protein sequence ID" value="EGN40138"/>
        <property type="gene ID" value="HMPREF0994_03308"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3616"/>
    <dbReference type="eggNOG" id="COG1904">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044465_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="471" mass="54275" checksum="0235A4C4E9AFDDD1" modified="2011-09-21" version="1">MKAFMDKDFLLSTDTAKKLFHEIAEPMPVLDYHCHINPREIAEDRKFENITQVWLGGDHYKWRQMRSNGVDEYYITGDAPDREKFQKWAETLELAVGNPLYHWSHLELQRFFGYHGILNGETAEDVWKLCNARLQEDSMSVRNLIRQSAVTLICTTDDPADDLRWHKALAEDRSFEVQVLPAWRPDKAMNMEKPDYTSYIEKLGAAAEMEIRSFAELKAALKKRMDFFESYGCKASDHALEYVMYVPETEENIEKIFAKRLAGENPDREEELKFKTAFMLFVAEEYAKRGWAMQLHYGCKRDNNTSMYGQLGPDTGYDCINNYAPSSQMADFLNALNIKGALPKTIIYSLNPNDDEAIGSIIGCFQNADAVGKIQQGSAWWFNDNKNGMMKQMTSLANLGLLGNFIGMLTDSRSFLSYPRHEYFRRILCELIGGWVENGEYPADEKTLKRIIKGISYNNAVRYFGFALEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC49</accession>
    <name>F7KC49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253332.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03431"/>
    <dbReference type="EnsemblBacteria" id="EGN39938">
        <property type="protein sequence ID" value="EGN39938"/>
        <property type="gene ID" value="HMPREF0994_03431"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3750"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="35086" checksum="915EED6A833A6157" modified="2011-09-21" version="1">MKKKTGLFNQRGFRLFLMISPLLLLVFIFSYMPLYGWIYAFFDYKPGRALLDCEFVGLQNFTRMVSDKYALEELIHVMKNTFGMSFLGILTSPLPMFFAIFLSEIKCIPFRKGVQTLTTIPNFISWVLVYSVAYAMFSVNDGFVNRLLMNLGIIEEGINVLASDKHVWLTMLGYSTWKSLGWNAIMYIACMSNIDEEQYEAAKVDGASRMQRIRYITIPGLMSTYFVLLLLSIANLINNGMEQYFVFQNAMNKQSIEVLDLYVYNQGMVGVNYSYATAVSMLKSVVSVSLLFFANKFSILVRGESVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC54</accession>
    <name>F7KC54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253338.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03437"/>
    <dbReference type="EnsemblBacteria" id="EGN39944">
        <property type="protein sequence ID" value="EGN39944"/>
        <property type="gene ID" value="HMPREF0994_03437"/>
    </dbReference>
    <dbReference type="GeneID" id="29728893"/>
    <dbReference type="eggNOG" id="ENOG5033MQT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876338_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="33300" checksum="115AC4662CF2ED8E" modified="2011-09-21" version="1">MNKDEFLNELKSYLSILEDEEQADILEEYTQHIDMKISTGLSEAEAIRDFGNVSELAAQILEAYHVKPGYREALPDRTGCGAVAVKPEKASVMDGIADYMDSIAGSIAETFAETGRELKRIWGEIRWGELRKNGTEVLETIWEVLGVPFRWLDRLFTGKKKEIDAEETLAEPEIIQSGKERADQNMFRDLCRSMGNGIAGIFTGIWRLFLWCVKWCWNGIMIAAALFGGICCMLLLFLLAMVLVWLLQGYPLAGAAIVCFGGVLCAGSFTVLCTTFLVRRQTNTGSRRMVKERTQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC74</accession>
    <name>F7KC74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253354.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03453"/>
    <dbReference type="EnsemblBacteria" id="EGN39526">
        <property type="protein sequence ID" value="EGN39526"/>
        <property type="gene ID" value="HMPREF0994_03453"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3773"/>
    <dbReference type="eggNOG" id="COG2818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083758_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="190" mass="22093" checksum="3A3E4DA1236C47C6" modified="2011-09-21" version="1">MCEKKRCSWAGDIPIYIDYHDNEWGRPVHDDNKLFEMLILEGMQAGLNWITVLKKREAFREAFDGFDPDKVALYGEEKIQELLANEGIIRNRLKVNAAVTNAKAFLEVQEKYGSFDKFIWSYVDYTPVKNHWKKMEEIPATTPISDQISKDLKKMGFKFVGSTIIYAFMQATGMVNDHVTDCFVYQEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC89</accession>
    <name>F7KC89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253369.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03468"/>
    <dbReference type="EnsemblBacteria" id="EGN39541">
        <property type="protein sequence ID" value="EGN39541"/>
        <property type="gene ID" value="HMPREF0994_03468"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3792"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="123" mass="14074" checksum="4260082A37CDD04E" modified="2011-09-21" version="1">MDQQISDAELDIMKIIWANEGPALFAHIMDALTAKGKTWQKNTVIMLLSRLKDKGYLKAKKIGRRNEYIPLVSETEYQTFQTKKLLDKVYEGNVKGLVSNLIQSDLLTGEEYRELKKLLDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCC9</accession>
    <name>F7KCC9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253400.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03499"/>
    <dbReference type="EnsemblBacteria" id="EGN39572">
        <property type="protein sequence ID" value="EGN39572"/>
        <property type="gene ID" value="HMPREF0994_03499"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="34149" checksum="7AE13D29371659B2" modified="2011-09-21" version="1">MSLRKTKKQAQPENKIYIGSKIFDVFLILFMLILSVIFLYPFLNVVATSLSSNRMITTGQVTFFPKEIMVDGYKMLFKEQNILGAYWNTIVIAVGTMVISLSLTSLMAYVMMVPDFVLRKQLSVFLLITMFFSGGTVPTYLLIQNLGLYNSWWSLILPNAVTAYNVFVYRSFYKGISPEIREAARIDGAGDLKILTKIYVPLSKALYATFGLFSVVGVWNSYYEALLYIKDPGKQPIQMLLRKIVFTSGTANMADSQQMISNGAMNQLNVQYACVIATIGPILLVYPFIQKYFAQGMQVGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCU7</accession>
    <name>F7KCU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253577.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39048">
        <property type="protein sequence ID" value="EGN39048"/>
        <property type="gene ID" value="HMPREF0994_03676"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4011"/>
    <dbReference type="eggNOG" id="ENOG50325WZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2751206_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="70" mass="8352" checksum="A7BCE66FF91775AC" modified="2011-09-21" version="1">MTQTIQESVKMLEMLPESEQEFASQFIRRLVLAWDPDFTKLTQEERKRLEASEQRIDSGEYVKDSDVNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCX4</accession>
    <name>F7KCX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253604.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03703"/>
    <dbReference type="EnsemblBacteria" id="EGN38867">
        <property type="protein sequence ID" value="EGN38867"/>
        <property type="gene ID" value="HMPREF0994_03703"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4042"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="298" mass="33493" checksum="ADD4F4EBE177F4A1" modified="2011-09-21" version="1">MNRKKFRFTSDKLFDLFNYAFLLILVLIIAYPLYYVLIASFSDPYEVYAGKTFLLPSKITFEGYARVFKEKSIATGYINSIYYTILGTAVSVALIITTGYCVSKKTLPFRRSIMLFYVFTMYFNGGLIPTYLVVAKMGLLNSVWSLILPGGVAVFNVIVARTFFESSIPEELYEAAAIDGSSNMRTFFKIALPLSKPILAVMVIFTMVAYWNDWFTALIYMSEKSKYPLQLALRQVLIQSQATATMIGNMDGGYAEANKITELIKFASIVVGSVPMLIAYPFVQKYFEKGFMAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDC2</accession>
    <name>F7KDC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_03854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253755.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03854"/>
    <dbReference type="EnsemblBacteria" id="EGN38619">
        <property type="protein sequence ID" value="EGN38619"/>
        <property type="gene ID" value="HMPREF0994_03854"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4196"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="349"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN38619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="587" mass="65286" checksum="747AF1641A744C25" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDH7</accession>
    <name>F7KDH7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253818.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03917"/>
    <dbReference type="EnsemblBacteria" id="EGN38682">
        <property type="protein sequence ID" value="EGN38682"/>
        <property type="gene ID" value="HMPREF0994_03917"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4261"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="427"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN38682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="528" mass="60659" checksum="827DC4AAF52FFC40" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDL5</accession>
    <name>F7KDL5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253861.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03960"/>
    <dbReference type="EnsemblBacteria" id="EGN38725">
        <property type="protein sequence ID" value="EGN38725"/>
        <property type="gene ID" value="HMPREF0994_03960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4311"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092782_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="30741" checksum="7D0E6E9B8A87895C" modified="2011-09-21" version="1">MYQHHEESLKILEDMFRGREEVIALVFGGSVAKGMERPDSDLDAMVIVTQEYFDQCMKENRTAECLSGCTYEGGYFDIKYMTKDFLEQAALKGSEPTRNSFVKSRVLFSRDPEIEGLVAAIPVFQEKEREEKLLSFFSDLELNYNYFWKCCKPDGYMKMRTGSEIVYALYRLILQEKRVLFPCNRRLEAAVEGIEDKPEGFVEKCREFCESMDSDLLDEIVESYFAWTSYDYPEDHNICCSQYCLDFEKWWLFPRPLIAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDY1</accession>
    <name>F7KDY1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_04060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37096.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04060"/>
    <dbReference type="EnsemblBacteria" id="EGN37096">
        <property type="protein sequence ID" value="EGN37096"/>
        <property type="gene ID" value="HMPREF0994_04060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN37096.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="234" mass="26938" checksum="9766F3784C2CBB20" modified="2013-09-18" version="2">MFEYLRKRITMKLLLVEDDKELNRTLTYQLEKEGFAVDSCLDGEEACYYMEEGLYDLILLDRMLPKLDGIGVLTEMRKKGDMTPVIMLTALGALTDKITGLDCGADDYLVKPFDFEELAARIRSIGRRPRRMEATEKLTFADISYEPVEARLTGPEDTCSLSRREGALMETFLRNIGQSLSRPILLYRVWGPDTDVEEGNLDNYIYFLRRRLKAVGSRVQLKTVRSIGYRMEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEP6</accession>
    <name>F7KEP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN36028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254226.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04325"/>
    <dbReference type="EnsemblBacteria" id="EGN36028">
        <property type="protein sequence ID" value="EGN36028"/>
        <property type="gene ID" value="HMPREF0994_04325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4722"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115794_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="202" mass="22248" checksum="66BB7FBB411C3AE8" modified="2011-09-21" version="1">MDMVSMFFNVISQVLMFSLIPFIWWLVTARRKENFFSWIGLKGVRGSWLAVGGCILFFFVLCVVSQVWWIPHLLPANATVQSSYAGMGWSAFPSAFLFGMIQTGLSEEILFRGFIGKRLIAKFGFAAGNVVQGLLFGALHGVMFFFVTTPLKALVITLITGFSGWLLGWMTEKGAGGSIVPGWMAHGVGNLVLSMVQAFGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF27</accession>
    <name>F7KF27_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04468"/>
    <dbReference type="EnsemblBacteria" id="EGN35778">
        <property type="protein sequence ID" value="EGN35778"/>
        <property type="gene ID" value="HMPREF0994_04468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_45_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="199" mass="23398" checksum="49B809D47C26C625" modified="2011-09-21" version="1">MNDKFFDLKKDKQDRIINAALQVFALNGYRHASTDDIVKLASISKGLLFHYFESKLGLYVFLYEYSSRFMLLEFSREIKETDNDLFLLMKKMETGRMRVLKMYPYMRRFLDMAEKEEWQAAVDAVAEAHKNYEDKIRNYLGQADYSALSPKAGREKVIKCVEYTLKGLTEDFSSRADFKPENLETEIDSYLQMFAAVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFH3</accession>
    <name>F7KFH3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureE</name>
        <name evidence="7" type="ORF">HMPREF0994_04602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UreE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04602"/>
    <dbReference type="EnsemblBacteria" id="EGN35049">
        <property type="protein sequence ID" value="EGN35049"/>
        <property type="gene ID" value="HMPREF0994_04602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093757_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00571">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036402">
        <property type="entry name" value="Ureas_acces_UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0533">Nickel</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="6">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="160" mass="17925" checksum="50519413AD345B49" modified="2011-09-21" version="1">MILCEKILGSMADPAFADCQADYVEIEWHEAYKRLHQKTTGSGLEIGIRLDTDILTRGLREGDILWQDDNWVIAVTIPPCEAIVIDVDAAHPDMVAKVCYELGNKHAALLWGETEMQFVTPYNEPTLQLLNKLHGVTACKKLVKFNFDKSISSTVSSHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFJ4</accession>
    <name>F7KFJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_04623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254524.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04623"/>
    <dbReference type="EnsemblBacteria" id="EGN35070">
        <property type="protein sequence ID" value="EGN35070"/>
        <property type="gene ID" value="HMPREF0994_04623"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357355" description="Histidine kinase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="187"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="254"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="475" mass="53747" checksum="943B6A01BEFB103B" modified="2011-09-21" version="1">MKLRQKIVISTLLLFMAVFTGANILTIENNCKLSFNRILQQARDEQESISSGIEQYVWAEGEKNGGDARYLNAVMEYLDSRVNTQGTALEILAQDRVLYSTLDFKQPVTVKANYIGRMAEYSRQEIDGKEYLILSSFFPLKDTQIRNLFFVDISGIYADRAQQYAFFLRLAAVTMLLLAAGLFLLTGRLTKTLRLLTASVRKIGEGNYRERIQIKAKDEAGELADSYNKMADAIESTVEELKRKNQEQQRFTDNFTHELRTPLTAVVGYADLLRSTSGDEEYVQELGECIFREGKRIERLSEVMMDLIFVRRHTFDMEPCDAGELLRESVMAYEPAAVKAGLRLETELPEKPVMIFGKKELLLAMFGNLLDNAGKASDTGGRIWIRLREEGGFVTAEVEDEGRGIPEEEQSRIFESFYQVDKVRNRKNNGVGLGLSLCADIAGIHEAEIKLASRVGKGTLMTIRFPCYKEVTKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFV3</accession>
    <name>F7KFV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04732"/>
    <dbReference type="EnsemblBacteria" id="EGN34658">
        <property type="protein sequence ID" value="EGN34658"/>
        <property type="gene ID" value="HMPREF0994_04732"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5164"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="34257" checksum="273BC230B5B2333E" modified="2011-09-21" version="1">MKNKVKFRKSLKKNSILYLFLLPMIIYVFIFNYMPLAGLQIAFKDFVATKGIWGSEWVGFKYFRQFFTSPMFWKLLKNTLVISLYQLVFSFPIPIILALILNYTPSQRLKKITQTATYAPHFISTVVLVGMMFVFFDPASGIGTSILKGFGMSNPQVLTDPAAFPHLYVWSAIWQTTGWSSIIYIAALSGVSPELHEAAIADGANKLQRIFYIDIPMLIPTAVILLILNCGNIMNLGFEKVYLMQTAPNLSTAEVISTYVYKIGLQGQQYSYASAIGLFNNIINFTILILVNQIAGKTTENSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGF0</accession>
    <name>F7KGF0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04929"/>
    <dbReference type="EnsemblBacteria" id="EGN34219">
        <property type="protein sequence ID" value="EGN34219"/>
        <property type="gene ID" value="HMPREF0994_04929"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975864_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="285" mass="31140" checksum="4B708002448B93B7" modified="2011-09-21" version="1">MRSMGKKGFTLVEIVVVMVVVGILAAITVPSLAKYIDDGKKRDCEINRKALLARLESDRALNPGAVMAGVLAENTDISCPSGGVYRAPDDNTVECSVHGKDSALSAAGDKAGGELVEIPEEESALPTEEGTIESSVPTEPEKQPVEMINDGTFVIGGKEFYYHVNLEDAQGSVELEQYHIYKLSNNKFAYAKENNLLDNPKGENSNLMKEIPSDANGSSKTIYDFQNEITEDSGNYSMNSKVKTGTVFLYNGQYFLRVGIDIEKGEWDGFPMETDGSNWIILYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGH6</accession>
    <name>F7KGH6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="5" type="ORF">HMPREF0994_04955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254856.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04955"/>
    <dbReference type="EnsemblBacteria" id="EGN34124">
        <property type="protein sequence ID" value="EGN34124"/>
        <property type="gene ID" value="HMPREF0994_04955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5411"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_9"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="77" mass="8533" checksum="4AE048D5D92AB38C" modified="2011-09-21" version="1">MLEKVIEIIQEQLNLEGVTITEESSFKDDLGADSLDLFELVMAVEEEYGVEIPAEELEKLTTVGSVVEYLKAQGIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGQ7</accession>
    <name>F7KGQ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254937.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05036"/>
    <dbReference type="EnsemblBacteria" id="EGN33745">
        <property type="protein sequence ID" value="EGN33745"/>
        <property type="gene ID" value="HMPREF0994_05036"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5500"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="26105" checksum="6FCEC5FEFC56E601" modified="2011-09-21" version="1">MDEFSNLKSKLLAEQVQDQLFRYILSTPVPVGNKLPNEFELGQKFGVGRSTIREAVKLLVSRKVLEVRQGSGTYVISTTPADLDPLGLRAVEDKMALALDLVDVRIMLEPGIAEMAALHASPEDVKKLDLLCRKIEKRINDGDSYIDEDIAFHSCVAECSRNVVVKQLVPIIDTAVLMFVNITHQKLTDETVRTHRAIADAIAEHDTIGAKTAMMMHLTYNRELIKRLIREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGR9</accession>
    <name>F7KGR9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3298 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05048"/>
    <dbReference type="EnsemblBacteria" id="EGN33757">
        <property type="protein sequence ID" value="EGN33757"/>
        <property type="gene ID" value="HMPREF0994_05048"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5514"/>
    <dbReference type="eggNOG" id="ENOG502Z8Z7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049430_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="2">
        <location>
            <begin position="223"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="35091" checksum="BB19D404FF8AB26C" modified="2011-09-21" version="1">MRKPEDGKKVYDNIEIPEELNNVVKDAIHSMDKGKSIKKHRTHNAVRIFRYCGTAAAALLVCMTIGLNTNEVFAREMGELPIIGSLAKVLTIRSYHEKDEGHDITVNVPEIQLDETQTGDADAGKETFVGDINQEIQTIVDDYVADAKQKFAEYKEAFFATGGTEEEWGNRDIAVNVDYEVKYQQGNILSMVLITDEAWVSAYGVRYYYNLDLSRNRQLTLQDLLGDNYVEIANESIIRQMKERDAADENAVYWGIGKAADDGMVDGFQTVDENTSFYINADGNPVVCFEKYEVAPGYMGFQEFEIQKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH60</accession>
    <name>F7KH60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_05196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862346.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05196"/>
    <dbReference type="EnsemblBacteria" id="EGN33229">
        <property type="protein sequence ID" value="EGN33229"/>
        <property type="gene ID" value="HMPREF0994_05196"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5675"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="176"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="463" mass="52684" checksum="BBE523B3D2E64D7C" modified="2011-09-21" version="1">MASIVKRKSKYSVVYDYTDENGKRRQRWETFSTNAEAKKRKKQIEYEQDSGTFFIPTAKTLNDLLDEYMSIYGVNTWAMSTYESRRGLARNYITPIIGDMLLSDITPRMMDKYYRDLLSVKTVSVNNRKPTSEYLTPHTVREIHKLLRSAFNQAVRWELISRNPVLNATLPKEEHKERDIWTAETLSKAMEVCDDPILSLALNLAFSCSLRIGEMLGLTWDCIDIAPQSIENGSAYIFVNKELQRVTRGALDDLSDKGVIKKFPPCIASTHTALVLKEPKTKTSIRRVYLPKTVAYMLVERKKEIDELMDLFGDEYIDNNLVFCSSNGRPMESQVINRAFNKLIKENGLPHVVFHSLRHSSITYKLKLNGGDMKSVQGDSGHAQVKMVADVYSHIIDEDRCINAQRLEEAFYSSKTPDPVEDTEPKTADTAVTESDESDAAKILELLKNPETAALLKQLAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH84</accession>
    <name>F7KH84_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05223"/>
    <dbReference type="EnsemblBacteria" id="EGN33256">
        <property type="protein sequence ID" value="EGN33256"/>
        <property type="gene ID" value="HMPREF0994_05223"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5703"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="302" mass="33813" checksum="071949DF83D22ECF" modified="2011-09-21" version="1">MKSAVKPSKRSRVLVRKETTAAYLFLLPSLIFFLGFVIYPIVLCVWTSFFDSTMNAKDVFVGFANYKELFQDKVFLGALKNTFIIVVVSVPITGAFSLWVSSIIVDLKGWATSLFRIIFYLPVVTGSVAVTVVWKWMFNNYYGIFNYLGTTTGLIEKNINWLGDERYALACIIIILLTTSVGQPIVLYVSALGNVDASLVEAANVDGATRFQAFWKVKWPQIMPTTLYILVITTINSFQCFALIQLLTSGGPNHSTDTIMYYIYYSAFKLYRYGYGDAMGVVLAIMIAILSAIQFKLGNSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHA1</accession>
    <name>F7KHA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002588983.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05240"/>
    <dbReference type="EnsemblBacteria" id="EGN33273">
        <property type="protein sequence ID" value="EGN33273"/>
        <property type="gene ID" value="HMPREF0994_05240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5722"/>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031118_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="470" mass="53394" checksum="455BE6E28D916206" modified="2011-09-21" version="1">MATTRIMPLHVGKGRTESRAISDIIDYVANPKKTDNGRLITGYACDSRTADAEFLLAKRQYLAATGRVRGADDVIAYHVRQSFRPGEITPEEANRLGVEFAKRFTKGNHAFVVCTHIDKSHIHNHIIWSSVSLEYDRKFRNFWGSTKAVRQLSDTICVENGLSIVENPKPHGKSYNKWLGDQAKPSHRELLRVAIDNALSQSPANFEELLKLLKESGCEVSKRGKSYRLKLPGWEKAARMDSLGEGYGLDDLQAVLSGKKAHTPRKKIVTQAETQKVNLLVDIQAKLQAGKGAGYARWAKVFNLKQMAQTMNYLSENNLLEYAVLEEKAAAATAHHNELSAQIKAAEKRMAEIAVLRTHIVNYAKTREVYVAYRKAGYSKKFREEHEEEILLHQAAKNAFDEMGVKKLPKVKELQTEYAKLLEEKKKTYAEYRRSREEMRELLTAKANVDRVLKMEVEQDVEKEKDHGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHR4</accession>
    <name>F7KHR4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05400"/>
    <dbReference type="EnsemblBacteria" id="EGN32841">
        <property type="protein sequence ID" value="EGN32841"/>
        <property type="gene ID" value="HMPREF0994_05400"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065103_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="33390" checksum="E121E5D6CC67D4B1" modified="2011-09-21" version="1">MDYDMLFSIGELANICGITPKTLRYYDKLGLLKPAYINTTNGYRFYTRWHITRISTIKQLQNIGISLDDIHTFFMQDDETNIVGCLSGLLKHQEKYIAAQLTELEQKQKKIRSLQLQCETLKGKTAYDESTGITIRPIPKRRILYTSYHGTYTPVLFRKCYQELLSDIKAAGYDPGEMELSAPLSIFCISENRNDSGNADIKLGYEMNNRQEVSLPALYLDEGLYACCICRGPYDRLKTELSRTLHETIKDMGYQIFSPQITYYYIHEAIAEDKNYLTEIQIPVKIMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHT0</accession>
    <name>F7KHT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255262.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05419"/>
    <dbReference type="EnsemblBacteria" id="EGN32860">
        <property type="protein sequence ID" value="EGN32860"/>
        <property type="gene ID" value="HMPREF0994_05419"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5922"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="331" mass="36463" checksum="AD3953B97901AA02" modified="2011-09-21" version="1">MNDYILQVENLKTYFKLDTGTLKAVDDVTFYLKRNETIGIIGESGCGKSVTAHSILRTVQNPGKVLGGRILYDDGSGPVDLVTCPPDSKAMRKLRGKDISMIFQEPMASLSPVYTIGAQMMEAVLVHQEKKDKKAAKELCMEMLRAVGMPDPEQKYNAYPHQMSGGQCQRAMIAIAMVNKPKILIADEPTTALDVTVQAQITDLMKHFQKEFNMSIIYITHDMGVIAEMADTIAVMYLGRVVESGSARAIFKNPIHPYTKGLLKSMPVLGNKSSERLHAIEGNVPVPLDPPDECGFCSRCQEKTAACAGSIPPLVEVEPDHLVRCFHYQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHZ5</accession>
    <name>F7KHZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571051.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05496"/>
    <dbReference type="EnsemblBacteria" id="EGN32937">
        <property type="protein sequence ID" value="EGN32937"/>
        <property type="gene ID" value="HMPREF0994_05496"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6010"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356919" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="91"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="526" mass="57976" checksum="38AC965FE686715F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI90</accession>
    <name>F7KI90_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255376.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05569"/>
    <dbReference type="EnsemblBacteria" id="EGN32394">
        <property type="protein sequence ID" value="EGN32394"/>
        <property type="gene ID" value="HMPREF0994_05569"/>
    </dbReference>
    <dbReference type="GeneID" id="29728907"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364070" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="405"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="542" mass="60376" checksum="DA3659D2C098BE79" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KID9</accession>
    <name>F7KID9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05618"/>
    <dbReference type="EnsemblBacteria" id="EGN32329">
        <property type="protein sequence ID" value="EGN32329"/>
        <property type="gene ID" value="HMPREF0994_05618"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6138"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="145"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="29151" checksum="0CE6EB1DBC4B891A" modified="2011-09-21" version="1">MKLLIADDELYMAEYIQKLVDWRDYGFDQVFVANGGSMARDILQDFVPELLITDIKMPRISGLDLSAFIDEKKYPTKVIIISGYSDFGYARQALHYGVSEYLVKPVLKGDLVETLERILQKNFVLEEKKEEDKICLAGDKNALISYVKNYIYENFDQNLSLDVLGEVVHLHPAYLSKIFKEVTNMNLSAYITDIRMQKAAELLEQTELKVHEVMELIGYRKSQYFSRLFKERFGVTPVEYRRTVKKDLSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIR8</accession>
    <name>F7KIR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004607957.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05757"/>
    <dbReference type="EnsemblBacteria" id="EGN32246">
        <property type="protein sequence ID" value="EGN32246"/>
        <property type="gene ID" value="HMPREF0994_05757"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6295"/>
    <dbReference type="eggNOG" id="ENOG50314Y6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184290_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025464">
        <property type="entry name" value="DUF4315"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14193">
        <property type="entry name" value="DUF4315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="92" mass="10313" checksum="3515AE862BECFF83" modified="2011-09-21" version="1">MAMNKIERIDKEIAKTREKITEYQNKLRGLEAQKTEAENLQIVQLVRSMRLSPHELSAMLSGGGIPGMEAAPGYPAEPADHDTEEMEDTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIS2</accession>
    <name>F7KIS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006876011.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05761"/>
    <dbReference type="EnsemblBacteria" id="EGN32250">
        <property type="protein sequence ID" value="EGN32250"/>
        <property type="gene ID" value="HMPREF0994_05761"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6299"/>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009097_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="812" mass="91195" checksum="407EDD1D264C6809" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIY3</accession>
    <name>F7KIY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="10" type="ORF">HMPREF0994_05812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255588.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05812"/>
    <dbReference type="EnsemblBacteria" id="EGN31888">
        <property type="protein sequence ID" value="EGN31888"/>
        <property type="gene ID" value="HMPREF0994_05812"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6355"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_9"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN31888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="31612" checksum="A68809142D2E34A5" modified="2011-09-21" version="1">MAIFEGAGVAIITPFHEDGSVNYEKFGEHIEAQIAGGTDAIIVCGTTGEASTLTHEEHLDVIRYCVKKTAGRIPVIAGTGSNCTETAVFLSREAEKAGVDGVLVVTPYYNKATQKGLFEHFKIVAESIKVPMILYNIPGRTGGVNILPETVVRLCREVPNIVGVKDATGNISQIAQLMSMAGDDVDLYSGNDDQIVPLLSLGGKGVISVLSNVAPRQTHDICARFFAGDVAGSRKLQLEAIPLCKALFCEVNPIPVKKAMNLMGLQAGPLRRPLTEMEEENAVKLEKAMKDYGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ47</accession>
    <name>F7KJ47_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255654.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05878"/>
    <dbReference type="EnsemblBacteria" id="EGN31506">
        <property type="protein sequence ID" value="EGN31506"/>
        <property type="gene ID" value="HMPREF0994_05878"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6432"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106617_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043735">
        <property type="entry name" value="DUF5680"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18931">
        <property type="entry name" value="DUF5680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="26771" checksum="B95CAE74EC9E3CD1" modified="2011-09-21" version="1">MTAIRFPFNLQKYRKARNLSQEDLAENLQVSRQAVAKWEKGANYPDILNLTLLADIFGVTVDALIYGNECTETAGTLPAFPLSSQKLAEFLLSAKKNSYAGNGTEEKQPCRPLAHDFIYEDEDFLYLDTYLGGTAFSGEEAVWEKQQDKRIPIWSMNYAGRILADGFNSRFLKEALSHVQKEAPFRGPELYRKEEYVYHCSQQGNMQWFQGREEIYYRNQKVYECEFHGGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJA7</accession>
    <name>F7KJA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255725.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05949"/>
    <dbReference type="EnsemblBacteria" id="EGN31577">
        <property type="protein sequence ID" value="EGN31577"/>
        <property type="gene ID" value="HMPREF0994_05949"/>
    </dbReference>
    <dbReference type="GeneID" id="29729580"/>
    <dbReference type="eggNOG" id="ENOG502ZUQV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1872782_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="15195" checksum="574C5179BF9EF1A4" modified="2011-09-21" version="1">MQNVIEELKRIQAAVTNLIEVLESSPENKTVSATVGEIRSVAILEEIYRCSGSVTPEQISEFAVKYGKTPSSCAGYYSGKKPSLKASDDRKRRLLTKQGEETVLAARHRWGDDWLDRIPQSIIANDATSYKMVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJD9</accession>
    <name>F7KJD9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SrtB family sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31322.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359901.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05968"/>
    <dbReference type="MEROPS" id="C60.002"/>
    <dbReference type="EnsemblBacteria" id="EGN31322">
        <property type="protein sequence ID" value="EGN31322"/>
        <property type="gene ID" value="HMPREF0994_05968"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034078_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05826">
        <property type="entry name" value="Sortase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009835">
        <property type="entry name" value="SrtB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03064">
        <property type="entry name" value="sortase_srtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31322.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="258" mass="29849" checksum="5A6BE50D74C8E26F" modified="2013-09-18" version="2">MKKWMKVIIPVCAVVVLIISCINLGSIFLEYNRGVQEYKELQEYVNNERPQLPAQEKEEDDFVMPEIDFAALKAKNEDFRYWLYIPALEVNYPVVQGKDNDIYLHRTFDGDSNSAGCIFLDAGNSPDLTDRNTVIYGHNMKNRSMFGSLKKFMQEEELAEENPYFYLYTEGEAIRYRIISYYMTVSGSDTYQSVYTDEDYDSYLKMALQKSLFKGYQKDYTEGQPDIVTLSTCHGKAGGTGRFVVHGVVDEIREWNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJG3</accession>
    <name>F7KJG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255768.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05992"/>
    <dbReference type="EnsemblBacteria" id="EGN31346">
        <property type="protein sequence ID" value="EGN31346"/>
        <property type="gene ID" value="HMPREF0994_05992"/>
    </dbReference>
    <dbReference type="GeneID" id="29725862"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6558"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005678585" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="375"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="513" mass="56201" checksum="14656BFD4AD13538" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJI2</accession>
    <name>F7KJI2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255791.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06015"/>
    <dbReference type="EnsemblBacteria" id="EGN31369">
        <property type="protein sequence ID" value="EGN31369"/>
        <property type="gene ID" value="HMPREF0994_06015"/>
    </dbReference>
    <dbReference type="GeneID" id="29723713"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6586"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="32677" checksum="AF728DFD4C20BF16" modified="2011-09-21" version="1">MLVYDQYIYPEKPDTDEDIIVFHSGFCSTTPNYSYGRDTRDYYLIHYVTRGRGTYQAGGRQWQLKENDGFLITPGTTIVHTADKNEPWDLCWVAFFGRKAGELLRKAGLDEDHLLFHYDRDDFLEACIKNIYNESRTGKNIASITGYFYLFAGRLIEMYEEKEKKKPDIVRFSRFDDAVIYIRRNIRSRITIENLANYMRLDASQVYRIFKKKTGLSPQQFITRMRMEKACEMLDKTDLPVREIAEWMDYEYQSHFTKQFRKEMGLSPTEYRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJI7</accession>
    <name>F7KJI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255797.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06021"/>
    <dbReference type="EnsemblBacteria" id="EGN31375">
        <property type="protein sequence ID" value="EGN31375"/>
        <property type="gene ID" value="HMPREF0994_06021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056499_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030949">
        <property type="entry name" value="ECF_S_folate_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04518">
        <property type="entry name" value="ECF_S_folT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="25628" checksum="41DFAD434BAB6995" modified="2011-09-21" version="1">MNAVSGSVRRITISAVFLSLSLVLKTTLTFDLPLFGQNGMRIGISGIFSILPALLFGPGYGAAVSGLSDFLGFLIKPTGGYLPLLTISAAAGGFLRGFLWEILKKKEDKRMRLLIAAGSGVLLVLGLGSALMTGEGMTPTAAGAAGGALLGIFLLAVDFVLSKKILPGGEKRKLPQLLIVMIVSGLAVTTVNTVILRETICTAWKTLPFIVVWLPRAAEELLGNIVLTCFAAVLLPLSGKFVKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJP2</accession>
    <name>F7KJP2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255857.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06081"/>
    <dbReference type="EnsemblBacteria" id="EGN31435">
        <property type="protein sequence ID" value="EGN31435"/>
        <property type="gene ID" value="HMPREF0994_06081"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6659"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014385_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="237"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="591" mass="67427" checksum="8FF1545B1305A677" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJT3</accession>
    <name>F7KJT3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255888.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06112"/>
    <dbReference type="EnsemblBacteria" id="EGN30738">
        <property type="protein sequence ID" value="EGN30738"/>
        <property type="gene ID" value="HMPREF0994_06112"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="111" mass="12779" checksum="CA6E9DECF42795C7" modified="2011-09-21" version="1">MEQYKIGKLIQKYRVQAKLSQEELAEKIDRSTIFVSYLERDVKNPSIETIVRLANVLNVSADMLLGIMTNKALSPRLHHIETLLQQLPAKSQMRILDILEASIAVEINYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJU5</accession>
    <name>F7KJU5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30750.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359916.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06124"/>
    <dbReference type="EnsemblBacteria" id="EGN30750">
        <property type="protein sequence ID" value="EGN30750"/>
        <property type="gene ID" value="HMPREF0994_06124"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065103_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30750.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="271" mass="31820" checksum="951BC604A063BBB4" modified="2013-09-18" version="2">MKKSKIQLTTAQFAKLHEVNKRTLHYYDTIGLFSPDTKGDNGYRYYNFSQSIDFEYIRMLKDLNMSIEEIQKYLHTLDSDSFIKIAETKEKEIDAQIQNLKRVRQILHAKKEQVKFCDTLQEQEIRITECEEEEYLILPYDFSEDDFSDLFTYIKDVWSIEQIRMGIGGFISVDKVLNEEFDDYDGIYTPALSGSSSAQRAIKPRGKYLCGYQKGAWDKLPLMYARMVSFAEENGFKLVGYAYELGLNEFVIADKNDYITQIMIRIEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJW4</accession>
    <name>F7KJW4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06153"/>
    <dbReference type="EnsemblBacteria" id="EGN30646">
        <property type="protein sequence ID" value="EGN30646"/>
        <property type="gene ID" value="HMPREF0994_06153"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6740"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="291" mass="33312" checksum="CDF4CF5E08C1AEB6" modified="2011-09-21" version="1">MKKRKFSLFDIILFLVFGLIAVITIYPFYNVFIVSLSNTLASATYSPYLYPHVIDFTGYRTIMNDPYFFKSLGTTLFVTIVGTTLNMVFSVTAAYVLSRKRLIGRKVFLSLILFTMLFSGGLIPTYLVVSGLGLDNSIWSMIFPGMISTYYLIIMKNYFVGLPVSLEEAARIDGANEFVVMTRIFIPISKPFMATFLLFYAVERWNEWWNAYLYISDKNIKPLQIYLRDVLVNFNSQLATQAQSIMNSQNKVFIQSIQMATIIITMLPILCVYPFVQKYFVKGVLVGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK60</accession>
    <name>F7KK60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256015.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06239"/>
    <dbReference type="EnsemblBacteria" id="EGN30508">
        <property type="protein sequence ID" value="EGN30508"/>
        <property type="gene ID" value="HMPREF0994_06239"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6837"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="34168" checksum="D7AA485435E67032" modified="2011-09-21" version="1">MKKKRRIKDLLQSVPFMLPSFAGMIVFSLLPILISIIISLTDWNGLDALNWKTLSGHFIGLDNYMKILTTAEFWKVLGHTLYYIVLYIPLVFVAALGVAVILNKSMKGITVFRIMYYIPVLTSWVAASLIWKWVLSPQYGIFNQLLSFVGIKGPSWLTSEVWAMPAIVLASVWKDMGFFGLFLLSGLKAIDVGYYEAARVDGAGKSKQFFRITLPLLTPSIFFCLIMSLINAFQLFPQVMIMTEGGPNGATQVMVERIYTYGFKYFKMGYASAYSWLLFIIIFILTGVQMKLQKGWVHYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKN8</accession>
    <name>F7KKN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ORF">HMPREF0994_06417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256179.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06417"/>
    <dbReference type="EnsemblBacteria" id="EGN48025">
        <property type="protein sequence ID" value="EGN48025"/>
        <property type="gene ID" value="HMPREF0994_06417"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN48025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="68" mass="7470" checksum="72CC53EB7636DA1B" modified="2011-09-21" version="1">MGNSSSEEKASKPKFFDGVKAEFKKITWPDRDLLLRQSVAVVGVSIVLGGVIAILDMILQYAVDFLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKX6</accession>
    <name>F7KKX6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256267.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06505"/>
    <dbReference type="EnsemblBacteria" id="EGN47516">
        <property type="protein sequence ID" value="EGN47516"/>
        <property type="gene ID" value="HMPREF0994_06505"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="490"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="621" mass="71574" checksum="83B70DF64FAB923D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL89</accession>
    <name>F7KL89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256372.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06618"/>
    <dbReference type="EnsemblBacteria" id="EGN46969">
        <property type="protein sequence ID" value="EGN46969"/>
        <property type="gene ID" value="HMPREF0994_06618"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7239"/>
    <dbReference type="eggNOG" id="COG0562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042118_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="148"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN46969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="366" mass="43239" checksum="4253474014F8355D" modified="2011-09-21" version="1">MKFKYVIVGAGLAGITMAERIATQLHEKVLVIDKRAQVGGNVYDEYNSDGILVQMYGPHTFHTNDKEVFDYICQYTKWHEYQHRVQSYVNGNFVPMPISLETINKLYNMNLSEDEMDAFIESKKIKIDEIKTSEDVVLSQGGMDIYEKFFKYFTIKQWGVDPAEMDKSVISRIPFRKNRDTRYFTDKYQGNPQGGFTQMCKNMLNHSEIKVMLNTDYKEVIDGIRYEKLIYTGPIDYYFDFKFGELKWRSIKFIFETHDCESYQPVASTRWPMDYDYTRITEFKKLTGQKHAKTTILKEIPCDGDEPFYTFPTAEWKALAQKYRNEATKEKNVIFLGRLAEYKYYDMDDVIRRALDVFSEMEKDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLN7</accession>
    <name>F7KLN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256519.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06766"/>
    <dbReference type="EnsemblBacteria" id="EGN46358">
        <property type="protein sequence ID" value="EGN46358"/>
        <property type="gene ID" value="HMPREF0994_06766"/>
    </dbReference>
    <dbReference type="GeneID" id="29726823"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7392"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066828_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="267" mass="30377" checksum="BBC458D2225789C6" modified="2011-09-21" version="1">MPPLYERHVKSNYQQHNRKVMYFRTHFPHTNEKLHTFTYPLRQTAKGVSLPASRQKRSLFRDYQGSMTAEASLAVPLFLFFMINILSMTLFFHTFAQNLETLHQQGRQLSMLAYVTGAEDEMIQLVRPARVKPVVPVLAYPGTNIVSCCYMRAWTGYDVERKFSGEEQEEYVYITENGTVYHRERNCTHLTLSIELAGKDEVGQLRNESGGKYYPCEKCGGDGSSFVYVTGEGTRYHNTITCSGLKRTVISIPLSEAGGRPPCSRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLP4</accession>
    <name>F7KLP4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TSCPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256526.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06773"/>
    <dbReference type="EnsemblBacteria" id="EGN46365">
        <property type="protein sequence ID" value="EGN46365"/>
        <property type="gene ID" value="HMPREF0994_06773"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7399"/>
    <dbReference type="eggNOG" id="ENOG5032YE7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176133_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023806">
        <property type="entry name" value="CHP03905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024434">
        <property type="entry name" value="TSCPD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12637">
        <property type="entry name" value="TSCPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03905">
        <property type="entry name" value="TIGR03905_4_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSCPD" evidence="1">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="82" mass="8599" checksum="0B553F3816EC8856" modified="2011-09-21" version="1">MKYRTKGTCSSSIDIEMDGNVIKSVIFTGGCNGNLQGISKLVEGMSAEDAISRLKGIKCGFKPTSCPDQLAIALESIVGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLS8</accession>
    <name>F7KLS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN46317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06807"/>
    <dbReference type="EnsemblBacteria" id="EGN46317">
        <property type="protein sequence ID" value="EGN46317"/>
        <property type="gene ID" value="HMPREF0994_06807"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7436"/>
    <dbReference type="eggNOG" id="ENOG5033B3W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209121_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="62" mass="6709" checksum="C20F40C1F681C952" modified="2011-09-21" version="1">MRYDGSRKSERVMELSHVKKTAAQALLLVVGIAMLCFGVWRGEAATVLSKAIKLCLECVGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRL7</accession>
    <name>S2KRL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07238"/>
    <dbReference type="EnsemblBacteria" id="EPC05089">
        <property type="protein sequence ID" value="EPC05089"/>
        <property type="gene ID" value="HMPREF0994_07238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="88"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="273"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="521" mass="57470" checksum="247C6BE0A58855A0" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>S2LA44</accession>
    <name>S2LA44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_07280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360271.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07280"/>
    <dbReference type="EnsemblBacteria" id="EPC05131">
        <property type="protein sequence ID" value="EPC05131"/>
        <property type="gene ID" value="HMPREF0994_07280"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="298"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EPC05131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="517" mass="58970" checksum="D0778A53302D8249" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>S2LA48</accession>
    <name>S2LA48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_07191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360120.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07191"/>
    <dbReference type="EnsemblBacteria" id="EPC05136">
        <property type="protein sequence ID" value="EPC05136"/>
        <property type="gene ID" value="HMPREF0994_07191"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EPC05136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="33947" checksum="30F0D2BF0053E53C" modified="2013-09-18" version="1">MTEIRIGTRGSRLALVQTGMVADALRACLPDARIETVIIKTRGDRILDKPLGEIGDKGLFVSELEAALLEKKVDLAVHSAKDLPMCLAEGLEILAVPQRADARDVLVQVRKKGSEGTGPEGAKAGFASLPPRPVIGTGSKRRELYVKELCPQARVELIRGNVETRLSKLEAGQYDGIILAKAGLDRLGIMEKEKERFSFTPLEPSLFLPAACQGIIAVEGRSDWEYREAVAQLCHRESLLSFEAERRVLEVLQADCSQPAAAYSVTEKTEETERFRLTVMYGGRQVQGEGGVKARLALADALSLQIRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2F1</accession>
    <name>F7K2F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00030"/>
    <dbReference type="EnsemblBacteria" id="EGN48263">
        <property type="protein sequence ID" value="EGN48263"/>
        <property type="gene ID" value="HMPREF0994_00030"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_217882_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024522">
        <property type="entry name" value="DUF3789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12664">
        <property type="entry name" value="DUF3789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="44" mass="4913" checksum="5AECED94F28590D1" modified="2011-09-21" version="1">MWSIITHLIAFTAGTVAGVVLLCLMQAGKMADEGYENMERRNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2F8</accession>
    <name>F7K2F8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249986.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00037"/>
    <dbReference type="EnsemblBacteria" id="EGN48270">
        <property type="protein sequence ID" value="EGN48270"/>
        <property type="gene ID" value="HMPREF0994_00037"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.40"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051658_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="232" mass="26714" checksum="F30B28B16A83A6E9" modified="2011-09-21" version="1">MGTKFEGVDILDFLGQVVELHTQHYKEDFDVDKELIQKVALSGEPEERRLLWMSRPCGTYCLSEREVYLQESNENKVWMFYHEQTNDPILAYALTLDGLQDGKVTGTIYPLDYPSHVERVKSLSCPIDRVTVTFEDGVQFTLPYQSRRRQINELMPEHGTPKSMQYAPESERELAVILRRERLKRDYHAKPGNVQEYMEKLKKASMRGRLKEAQAAVAAPGRGAPHKGGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2P3</accession>
    <name>F7K2P3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">HMPREF0994_00122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250071.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00122"/>
    <dbReference type="EnsemblBacteria" id="EGN42739">
        <property type="protein sequence ID" value="EGN42739"/>
        <property type="gene ID" value="HMPREF0994_00122"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.129"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="478"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="540" mass="57300" checksum="98A56E6A939016B5" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Q9</accession>
    <name>F7K2Q9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250087.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00138"/>
    <dbReference type="EnsemblBacteria" id="EGN42755">
        <property type="protein sequence ID" value="EGN42755"/>
        <property type="gene ID" value="HMPREF0994_00138"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033229_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357044" evidence="1">
        <location>
            <begin position="27"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="598" mass="65822" checksum="6DB19798D6952BAE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2R3</accession>
    <name>F7K2R3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250091.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00142"/>
    <dbReference type="EnsemblBacteria" id="EGN42759">
        <property type="protein sequence ID" value="EGN42759"/>
        <property type="gene ID" value="HMPREF0994_00142"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.151"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902518_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="172"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="35199" checksum="288FA76B1B51B2EB" modified="2011-09-21" version="1">MAYGSIPLEKRLRENIKSYKLENLYDLEKVQKLFRDLGEAFGMELLLTQRHGETAVAVGDFSDFEPDVETEPGRKIRVAERTIGHLYVKLSSPEAGQKIEAVLDDLAELYSFLGEKQYRFRETAIYADELEETLEKDRYQAKHGEHVDALTGLLNKTYFDGRLKLLKETGTAPDALICVNINDWKFVNSNYGDEESDRLIKTVADILKREAKPDYLIGRVDGDVFYIVIEVPEDGEALDYCRRIKEACLAFEDSLLAPSVAIGMVTRLSVEEDFAEGFSEAEYEMFRDKFDEKNSPGYRERLEKGLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V8</accession>
    <name>F7K2V8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250136.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00187"/>
    <dbReference type="EnsemblBacteria" id="EGN40744">
        <property type="protein sequence ID" value="EGN40744"/>
        <property type="gene ID" value="HMPREF0994_00187"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.199"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="118" mass="13454" checksum="9C8251AE40FD7BD0" modified="2011-09-21" version="1">MKMRNSYTCPLELTHDIIRGKWKPIILWQLGKGAASPSALQNDIVGIGQKMLLQQLGELQNFGMVQKEQYEGYPLKVKYSLTEKGERMLNIIAAMQEIGIELMKDDGREEFLKNKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K322</accession>
    <name>F7K322_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37890.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359816.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00251"/>
    <dbReference type="EnsemblBacteria" id="EGN37890">
        <property type="protein sequence ID" value="EGN37890"/>
        <property type="gene ID" value="HMPREF0994_00251"/>
    </dbReference>
    <dbReference type="GeneID" id="29725861"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479743_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37890.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="570" mass="63214" checksum="209B05401F3787BF" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3B9</accession>
    <name>F7K3B9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250301.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00352"/>
    <dbReference type="EnsemblBacteria" id="EGN33493">
        <property type="protein sequence ID" value="EGN33493"/>
        <property type="gene ID" value="HMPREF0994_00352"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033Q31">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982461_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363474" evidence="1">
        <location>
            <begin position="30"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="276" mass="31360" checksum="CEFF50B75B3216DF" modified="2011-09-21" version="1">MKKKVRNLSFLLFVVLIMALSIWGPEALAKYKDRAILDETHEQTVESASEGYRYTLNSNEKLYILSRCLNSQSLPESEQNALTRKEAENVDFPDLEGAYAFVVNHRGPSGKEITSEEIYEACNKGLEMLKELDILPDGVRKVDAASYDATLYSAIDVPEPQNNVAVWKMSLSTSQKNANKENRLIDAYIDADDGKIYEFYVRTSRVWEDMDPDEIAARWSGYMGLTDPEPYEAANPLMESTPYFKKYVYSGMGNEETIVTIGFYEGINELFLKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3D7</accession>
    <name>F7K3D7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250319.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00370"/>
    <dbReference type="EnsemblBacteria" id="EGN33511">
        <property type="protein sequence ID" value="EGN33511"/>
        <property type="gene ID" value="HMPREF0994_00370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.400"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="382" mass="41497" checksum="E0935EA56372D572" modified="2011-09-21" version="1">MNEKNRQTLFLIVFGILLFAVVMNFSVVLTFLRRIADLLFPILLGLLFAFVLNVPMTGFEKLLTRLSDRAKHEPSIRLLHGMSLMLTLLCIAFVIFLAFALVLPELAESAKSVWPLLKEQWPVWMEHLKACRIDLSAISGWVAKLNMKTLAGGADNVMDSAMQAAASTVSGVANTVFGLVISIYILISKSTLGPQVRKLIGANLKKSTAERICSIASLIRETYSKFLSGQCVEAILLGCLIFLAFSLFRLPYAGLTGFLTSLFAFVPYVGAFASCFIGALLTLLAAPSKVLLCVLVYLAVQFIENQFIYPHVVGNSVGLSPLWTLIAALLGGKMFGLPGIIFFIPLVAVIYSLVRENTNRKLKRQAAAGGAAGIKGVSDQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3I6</accession>
    <name>F7K3I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250364.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN31930">
        <property type="protein sequence ID" value="EGN31930"/>
        <property type="gene ID" value="HMPREF0994_00415"/>
    </dbReference>
    <dbReference type="GeneID" id="29724726"/>
    <dbReference type="eggNOG" id="ENOG503135J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749612_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="369" mass="43425" checksum="CDEA366FAD809BE9" modified="2011-09-21" version="1">MKYWAERWAELRQKEMVDFPEEFFIHDEFTTLCSPDDIMRGFSELYEVLHRIYGDMAQDAEGMLLPLFDMQEYDYFAKETRVSREASYKYAKLLYALGCSGEPDHKCGLLVNVNELNRLCKELKVTNISRHLTILENYGFTAEGLETGRIKKGTEDITVRYLNNTHLMDVLYLMAKKVRCTNRLTDFFRLHYKLFADDWNTAAFGNGVDFVSDLYKSEQDKLSAQYIHKELLSRNYFFSRQTWNEGPQIRYYKSEADCKRNTNARFWLTSMDTNLLLYFRISNVEKALDYIKNCPERVFNTFLVSDKGCQKRGTECVSGITYTLQDKTIWRCGCCNPNFQAVPLPEDYIYYINAAEIGDMRSLQYKCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Y7</accession>
    <name>F7K3Y7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Flagellar M-ring protein FliF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_00566</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250515.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00566"/>
    <dbReference type="EnsemblBacteria" id="EGN44754">
        <property type="protein sequence ID" value="EGN44754"/>
        <property type="gene ID" value="HMPREF0994_00566"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.614"/>
    <dbReference type="eggNOG" id="COG1766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028108_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="11">
        <location>
            <begin position="52"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="12">
        <location>
            <begin position="263"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN44754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="536" mass="58642" checksum="DDB5F439DD6EF50F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4D5</accession>
    <name>F7K4D5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250663.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00714"/>
    <dbReference type="EnsemblBacteria" id="EGN44063">
        <property type="protein sequence ID" value="EGN44063"/>
        <property type="gene ID" value="HMPREF0994_00714"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.773"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="27661" checksum="645658762DB51DA1" modified="2011-09-21" version="1">MLHIKNIEKYYGSKNNVTKALDRISFDVEDGEFIAIMGASGSGKTTLLNCISTIDTASAGSILLDGENITEIPSGELARFRRERLGFVFQDFNLLDTLTLEENIGLALTINHADALTVQKKVHDVAIKLGIEDALSKFPYQVSGGQKQRAACARAMVAGQSLILADEPTGALDSKSSKNLLEIMTRMNRDMNATILMVTHDAYSASYASRILFLKDGRLFNELIRGERTRTVFYHEILDVLALLGGDISDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4E7</accession>
    <name>F7K4E7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250675.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00726"/>
    <dbReference type="EnsemblBacteria" id="EGN44075">
        <property type="protein sequence ID" value="EGN44075"/>
        <property type="gene ID" value="HMPREF0994_00726"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.788"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="26120" checksum="FF9C0E2CA0320723" modified="2011-09-21" version="1">MSQLICQDLALGYAGKAIVRNLNFRVNAGDYFCIVGENGSGKSTLMRTLLHLQPPVSGSILTGDGLKTNEIGYLPQQTLVQRDFPASVREIVLSGCQGRCGSRPFYTKAEKELAEENMEKLGIKDFSGRCYRELSGGQQQRVLLARALCATRKLLLLDEPVSGLDPKVASEMYALIGRLNRQDGITILMISHDIGAALTYATHILHMGEKIFLGTKQEYMDSDIGRRFTMPEGGEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4G2</accession>
    <name>F7K4G2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00745"/>
    <dbReference type="EnsemblBacteria" id="EGN44094">
        <property type="protein sequence ID" value="EGN44094"/>
        <property type="gene ID" value="HMPREF0994_00745"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2770596_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="69" mass="8057" checksum="9BFE733935A1958E" modified="2011-09-21" version="1">MMEDKGTALWAVPCLMDYNFFKAAINLPDTPCESRLFFSEISNRLRRSKAGTYNNLIKQRFDSREDVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4U2</accession>
    <name>F7K4U2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250820.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00871"/>
    <dbReference type="EnsemblBacteria" id="EGN43180">
        <property type="protein sequence ID" value="EGN43180"/>
        <property type="gene ID" value="HMPREF0994_00871"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.949"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_8_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="313" mass="36502" checksum="027874CD55E3835B" modified="2011-09-21" version="1">MVRRYITDSNILREINDFRPGIWVNMVNPTLEECTLVANEFQVDITDIRAALDDEESSRVDVSNDYTMILFDIPSIEYRHKREAYTTLPLGLIFAADTLITICAEETPVLKYFTENAVKEFSTKKQIRFIYQIILRTCMLYQSYLRIVDRRRKEIEEHIGGDTEDVDLIDLHELESNLVYFDTSLRANKMVLERLVRYSKIKKYPEDQELLEDVVVENQQAIEMTQIYRDIIKGTRELLSSVIDNRLNTAMKYLASITIVMAIPTIISGIYGMNVDEKWMPLANTPFGFGIICMLTLLLCILVIRILRKRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K584</accession>
    <name>F7K584_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, family IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00932"/>
    <dbReference type="EnsemblBacteria" id="EGN43241">
        <property type="protein sequence ID" value="EGN43241"/>
        <property type="gene ID" value="HMPREF0994_00932"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118951_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="209" mass="24600" checksum="C1278A676C137CA2" modified="2011-09-21" version="1">MRTILFDMYGVILKESKGNFIPYTFDYFSDQERERLIRQFRDEQLFTKAGSGLISSDDFLLQLGFTDPQHHMKNYLENYLTLDNGFIPFAEKYYNEFRFVLVSNDVSEWSAYITEFYNLNKYFREKIVSGDIKCRKPDIRIFNYALEQSKSIPQECIFIDNSVENLAMAESLGIIPVLFNRDNVAYEGLTVNSFEELEQLIIKGIRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5B5</accession>
    <name>F7K5B5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU family SUF system FeS assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250993.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01044"/>
    <dbReference type="EnsemblBacteria" id="EGN43017">
        <property type="protein sequence ID" value="EGN43017"/>
        <property type="gene ID" value="HMPREF0994_01044"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1142"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="144" mass="15888" checksum="B823AA261E58A30E" modified="2011-09-21" version="1">MENKTFYQEILLDHNRNPAHKHPLPDADLELEGVNPSCGDDIVLQLKIENGMVADGAFHGNGCAISQASADMMLDLVIGKTKEEAGRLTGIFLKMIQGQAAPEELEELEEAVCLQDVAHMPARVKCAVLGWHTLEELLKTEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5W7</accession>
    <name>F7K5W7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251195.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01246"/>
    <dbReference type="EnsemblBacteria" id="EGN42446">
        <property type="protein sequence ID" value="EGN42446"/>
        <property type="gene ID" value="HMPREF0994_01246"/>
    </dbReference>
    <dbReference type="GeneID" id="29723460"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079356_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="224" mass="24625" checksum="201332BDF004C782" modified="2011-09-21" version="1">MKKVAVIHTTPVTIPTLKKLLTENRRPDEEEIEVINFLDDSMLPEINRLGHPSEGVKYRLNTLLLLCQTTGADAVLCACSSIGGLVEEGSSLVGIPVFRIDEPMARLAAGYSRIGVAATLHSTIMPTTELIRRKAVMVGNEISIRSTVIENVGNLLAENKGDLYDEMVGEQLRLLLEENEVVVLAQASMARAVEKWPEEEKSRCLTSPVSGVEAVRDYLRKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5W8</accession>
    <name>F7K5W8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251196.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01247"/>
    <dbReference type="EnsemblBacteria" id="EGN42447">
        <property type="protein sequence ID" value="EGN42447"/>
        <property type="gene ID" value="HMPREF0994_01247"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1364"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="268"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="812" mass="92449" checksum="4D69A541E6E37EE3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6C0</accession>
    <name>F7K6C0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptide epimerase</fullName>
            <ecNumber evidence="6">5.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251357.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01408"/>
    <dbReference type="EnsemblBacteria" id="EGN42270">
        <property type="protein sequence ID" value="EGN42270"/>
        <property type="gene ID" value="HMPREF0994_01408"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1530"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="7">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (R)-substrate epimerization" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (S)-substrate epimerization" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="358" mass="39283" checksum="9F33988576A312C3" modified="2011-09-21" version="1">MKITDIKAEKVRIELTVPFRVAFAEINYSENLLLKVSTDEGIDGYGEAAPMPFVTGETIDSVISVINMIRPGLIGMDPMDIEKIHELMDTCIYGNSSAKCAVDLAMYDLMGKFMGQPVYKLLGGYSNRVQNDITIGISTPELMAEEARQHVLKDGFHILKIKAGINVEEDIRAMRLIRETVGPHIRLRVDANQGYSASDAVYAIQEFKKTGIEAVEQCLPHWDFEGSAYVRSKVSGIRIMLDESIHNHLDAARACKNGCADILNIKLMKCGGLFRASQINSIAEAFGVTCMVGCMMETKLATTAGVSLVAAKKNITEADCDSFLFYADEQTGMTGGFTRDNDIFTLLDAPGFGLDLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6J8</accession>
    <name>F7K6J8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01508"/>
    <dbReference type="EnsemblBacteria" id="EGN41982">
        <property type="protein sequence ID" value="EGN41982"/>
        <property type="gene ID" value="HMPREF0994_01508"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1646"/>
    <dbReference type="eggNOG" id="COG1895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151247_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="15998" checksum="401FC0FCD94596DA" modified="2011-09-21" version="1">MSDERKKALCEYRMQNAQESFSVAEDCYMKNHFKDSINRSYYSVFYAVKAVLSLEGIDFKRHKDVIAYFNHTYVATEIIPRSFGRKIGQLQQRREKSDYDDFYIASKEEALEQLNNAKAIIEVIRKYLEEKGGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K702</accession>
    <name>F7K702_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251358.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01409"/>
    <dbReference type="EnsemblBacteria" id="EGN41883">
        <property type="protein sequence ID" value="EGN41883"/>
        <property type="gene ID" value="HMPREF0994_01409"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1533"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066636_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="70"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="326" mass="37245" checksum="7FFAC052F38B938F" modified="2011-09-21" version="1">MAGEKDLAVMRFLEKPENFSDLFNGSLFQGKQVLKAEMLESMSGRSALSFRDKDGRKVSVRRYRDAVCKASGHTAYAVFAVEGQGETHYAMPVREMVYDAMNYAGQVKALSDKHRKKKDYRDGAEFLSGLLREDRLAPVVTICFYYGTGEWEGPLDLFDMLDIPEEYEDMKPFMTNYKVNLVQASNVAPDNFRTDLRHVFSLLGMAADGAGMKRYIQERPEEFRHISYETFDCLRELLHVDKWWKTDGFERKGEVDMCKALEEIAEMAKDEGKAEGKAEGVRVGIKALAEICEKLGVPFEQTVEMVTEKFGMPSEDARESVELYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K769</accession>
    <name>F7K769_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251611.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01698"/>
    <dbReference type="EnsemblBacteria" id="EGN41736">
        <property type="protein sequence ID" value="EGN41736"/>
        <property type="gene ID" value="HMPREF0994_01698"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="326" mass="36328" checksum="F6DED557BEC6171A" modified="2011-09-21" version="1">MTISKGTTIQQIAELANVSTATASRVINQPETVKPETLRRVLQVMKELNYQPKQNITRLLLATFPNFTNPFYSLCIRGMQEAARKRNYKIYLQQIDDPTKTESYDFLLDNHLFHGIIFTHPLPDKQLLDLILIKHPVVMCSQYSISDDVPCVVIDDYAAAQNAVSYLISIGKKRIALMNSQQDYSCSLYRENGYLDTLKEAGLPVYPEFITHVNDVDYSLALSAALNMLSGKVRPDAVFCISDVFASAVIKAAGQLGLSVPKDVAVMGFDNVALCNMTIPTISTVSQPMYQLGWQSSNLLIDQLEGIPVVSKRIVLNTDIIVRKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K772</accession>
    <name>F7K772_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="15" type="ORF">HMPREF0994_01701</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251614.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01701"/>
    <dbReference type="EnsemblBacteria" id="EGN41739">
        <property type="protein sequence ID" value="EGN41739"/>
        <property type="gene ID" value="HMPREF0994_01701"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1859"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="285"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGN41739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="42778" checksum="08A88BB1D8987EA2" modified="2011-09-21" version="1">MKEKILQKFGEVFGDTTGVKTYFAPGRVNLIGEHTDYNGGHVFPCALTIGTYGVARQRADRKLRFYSMNFEHLGVLESSLDGLKPEKDADWTNYPKGVMWAFEKRGMEIPYGMDLMLFGNIPNGSGLSSSASVEVLTGFILRDMFGFDVTNQDLALIGQYSENNFNGVNCGIMDQFAIAMGKKDHAIFLDTADLSFEYAPIQLEGAKIVIACSNKKRGLGDSKYNERRSECETALAEIQEVVGIKSLGDLTEEQFEQYKTAVKDDVRRKRAKHAVYENQRTIKAVAALKANDIEQFGQLMNASHVSLRDDYEVTGIELDTLVEEAWKIDGVIGSRMTGAGFGGCTVSIVKTDAIDSFIEKVGAEYLRKIGYAADFYVVEIGDGPSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7M1</accession>
    <name>F7K7M1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251828.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01915"/>
    <dbReference type="EnsemblBacteria" id="EGN41320">
        <property type="protein sequence ID" value="EGN41320"/>
        <property type="gene ID" value="HMPREF0994_01915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2099"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="290" mass="32136" checksum="BB7FFDF0981458BC" modified="2011-09-21" version="1">MSKENKTKIKQKVNWKKELSLLPGYIIVLVWIIFTAAFLFWILGASLSTSREIFSGTVFKFESGFHLENYVNAWQAQNVSVFFANSLLYAVVSCVGVILISAPGAYVLSRFDFICNKAIKSGLIVAMSIPAVMIIMPIFALTTKWNVKGRILLILLYIFLNVPYTTTYLLNFFATLSKTYEEAAAIDGCPPAKTFWVIMLPLVQPALITVTIFNFLGVWNEFFMALIFASSEKMTPVGVGLLQIVNSMKYTGDYGGLFAAVVIVFLPTFLLYIFLSEKIIAGVTGGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7N9</accession>
    <name>F7K7N9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251846.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01933"/>
    <dbReference type="EnsemblBacteria" id="EGN41338">
        <property type="protein sequence ID" value="EGN41338"/>
        <property type="gene ID" value="HMPREF0994_01933"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2122"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="449" mass="49527" checksum="D580251E78786DE5" modified="2011-09-21" version="1">MKQKTDTLFYRNFFSIYVILVLQNVVTLSVNLADNMMLGAYSETALSGVAAVNQIQFIYQQLLMALGDGLVIFCSQYWGQRRTEPMKKIAAGAMWAGLGIAVILFTLVSIFPYQTLGIFTTEKSIIEEGVRYLAIIRFTYFFFAVTQILLATMRSVELVNIAFQLSIITFFINCGINYVLIYGHFGAPEMGAAGAAVGTLAARAIELLVLLFYIRKKETNLRLRLSDYFHPDKLLCRDYFKLTAPMLLVQGLWGVNTALQTVILGHMTAAAIAANSVASTIFLMVKSMAVGAASTASVIIGKTIGTGDIDLVKHYAKLMQRLFLIIGVVSGLVLFVIRVPLLRIYDLTPATKDMANTFLIILSIVIVGMSYQMPTNNGIIRGGGNAMFVVKMDLISIWGIVIPLSFIMAFVVKASPAVVVCCLNADQIFKCVPAFLESHYGNWIRKLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7R7</accession>
    <name>F7K7R7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251875.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01962"/>
    <dbReference type="EnsemblBacteria" id="EGN41367">
        <property type="protein sequence ID" value="EGN41367"/>
        <property type="gene ID" value="HMPREF0994_01962"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2155"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="34685" checksum="5FCC7AFFE711EF86" modified="2011-09-21" version="1">MKALVKERGIKKTKGDIVFGILNYAVFGLFTLICFYPFYYLIINSVSANDLSSNGSINFLPSQLHLENYKQVLQLKGLGLAALVSVGRTIIGTICTVLASAFLGFMFTQERMWRRKLWYRLMVVTMYFNAGLIPMFLTMQNLHLTNSFWVYVIPVIVQPFNIILVKTYMESIPRSLQEAAEIDGAGIMKVFLKIILPTSTPILATIAIFAAVAQWNSFQDTLIYVTDQKLYSLQYILYQYINQANSLATMVKNSSGGTNLNMAALATQQTPTSIRMTVSVIVVMPILFIYPMFQRYFVKGIMIGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7T7</accession>
    <name>F7K7T7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251895.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01982"/>
    <dbReference type="EnsemblBacteria" id="EGN41387">
        <property type="protein sequence ID" value="EGN41387"/>
        <property type="gene ID" value="HMPREF0994_01982"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2179"/>
    <dbReference type="eggNOG" id="COG3935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050990_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017019">
        <property type="entry name" value="DNA_replication_prd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033722">
        <property type="entry name" value="DnaD_CA_C3587_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="43660" checksum="2A493CF7597DC4B2" modified="2011-09-21" version="1">MSCLRIYQDNYIDATIVSNRFIDEYMAEANDAQLKIYLYLLRMMNAGRTFSISGIADAFNHTEKDVMRALKYWEKCKVLSLEYDNEKNLVGIHLLELENKEEPAVSKAPVVSLLPRQEEKNEEAEILPEKAEAKSAVSYAVQSPSKEENKPPQAAPSAFAKPSYTLDELKAFQEKESTAQLLFIAEQYLGRTLSPSDMKSILFFSDHLHFSDDLIDYLLQYCVERGKKDFRYMEKVAISWAEANISTPAEAEGHASRYDKCVYSIMNALGKTNSPTRKEAEFIRRWREEYAFETDIIIESCERTVLATDRHRFEYADKILASWKEAGVHHKADIAKLDEGFQKNRPAKPASDRSIDKYNRFMHNDYDYDALEQELLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Y3</accession>
    <name>F7K7Y3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M56 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02029"/>
    <dbReference type="EnsemblBacteria" id="EGN41434">
        <property type="protein sequence ID" value="EGN41434"/>
        <property type="gene ID" value="HMPREF0994_02029"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054567_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="88"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="372" mass="44101" checksum="0D155F0E5537E35C" modified="2011-09-21" version="1">MQITLSSVVNTILCTSLMFVFIIITLKYRFFFKRLSFYTIILCFLLIAIRLFFPYEFYFVKEIPVRKVMPQLYEFLYHFELTFGNFNVSVLKFLSISWIAVSIVLLIKLMLDYHKTRYMLLKMRSVNDSDIIAALNEVNSKYNKKVSFTLVSSSIISTPLLFGIRKPIIALPQVFLTHKELCYIFEHELCHYYKKHLHIKLFCEFITVIYFWNPLIFMIKKLLNKVLEFYVDAKVNENLTENEKIEYLECILKIAKMKQTNQQSLFCTVPFSIISSPRLLERGNILLNNSRHRNFPLINRLFLLSALVLTIFSYSFICEPYYISEEYAENTFNKDNAYFVLNAENTYDLYVDSVYVSTVTKVFDPKIPIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8A0</accession>
    <name>F7K8A0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01873"/>
    <dbReference type="EnsemblBacteria" id="EGN41278">
        <property type="protein sequence ID" value="EGN41278"/>
        <property type="gene ID" value="HMPREF0994_01873"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50334SD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108840_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025467">
        <property type="entry name" value="DUF4318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14201">
        <property type="entry name" value="DUF4318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="207" mass="23756" checksum="38E0319DB62F9E34" modified="2011-09-21" version="1">MTKTNIRNKELYMESIKRGSLVGGIIWVCVVIFISINYKTMGKAALPWLVPMLAGYIVLGALLQLGTVKKRMINGLAALWSIIIIMFALICIAYYIPDWIRYIIVLSFFVLVVIWVGDYWYLSRMARKLNQGRSGYALCISLKEKPSSKEDFLRKFEDYCYRENISLEYEVKDVPAIVLMDGIRCEVRLDSTPGFGGAEYMMKVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8R9</accession>
    <name>F7K8R9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">HMPREF0994_02266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252167.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02266"/>
    <dbReference type="MEROPS" id="T05.001"/>
    <dbReference type="EnsemblBacteria" id="EGN41173">
        <property type="protein sequence ID" value="EGN41173"/>
        <property type="gene ID" value="HMPREF0994_02266"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2474"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023555332" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023555333" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="152"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="364" mass="38716" checksum="91F4018231839043" modified="2011-09-21" version="1">MKMEKYAGYQYIEGGVCAAQGFTANGLNCGLNPDKAKNDLGMVYSERLCTAAAVYTTNKVKGAPVLVTKRHLGMSGGRAKAVIVNSKNANTCNADGVEIAEKISELAAQALEIRPEEVIIASTGVIGQPMSPEPFAAHMQELAAGLSREEHTAAAAVSTEMLQTALSDIVEITYNCLSIDGDTSTNDMVSIMANGAAGNPEITMDGTEYQSFRQALYIVMATMTKMLAADGEGATRLLECSCVGCPDRQTAVSIAKSVVQSSLVKCLLFGCDANWGRIMCAIGYTDADFDIDKVDVDVASAAGTIEVCRGNAVILPFSEEKAAEVLAEDEIHININLHQGEEQAKAWGCDLTYDYVKINGDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8S7</accession>
    <name>F7K8S7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02276"/>
    <dbReference type="EnsemblBacteria" id="EGN41183">
        <property type="protein sequence ID" value="EGN41183"/>
        <property type="gene ID" value="HMPREF0994_02276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541542_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="394"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="507" mass="57161" checksum="A14EEA6679EE4DC7" modified="2011-09-21" version="1">MPHPIPTAISTATAMLTNNIVYAYGFKYEPITPTKINTLASMYPTVYTPSIKTMTLNKVGKIGIDCSGFICKAFGIPHIGSSQLKSQMIHLYPTSDPSHLVNGMLIWRSGHIGLIEVDDTGEAWILEAKSTADDLVRTKYSARGNSFTYYGELTGVDYTNARKINSPTQSSSSAPLRELIDISHHNTINLSLTAAKFKDIIIRAGYRSSTTGSLIQDKKFTEHTREALANNMRLGFYFYDQSINETEAIQQADWTISQIKDYPVTYPVYIDSEYANQSHSGRADNITKDQRTKNIIAFCSRIKEAGFFPGVYASDNWFKTMLNYSQLKQFDIWCARYSVNPPSVEKYEIWQYGSANIPGSVNPIDVNHLYKEYCTDPLPPSHPAPLLWNEITASTLNIRNAPSTSGKILYQMHKGDKVNIYLLQNNWCKISSTDEIWCSYKYIHSSQGAVSNCSKLNCRRTPVSGQADFILSVNDTVNILHQDLLTNWFYIEFHGKTGYVSNKYIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K912</accession>
    <name>F7K912_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02341"/>
    <dbReference type="EnsemblBacteria" id="EGN40998">
        <property type="protein sequence ID" value="EGN40998"/>
        <property type="gene ID" value="HMPREF0994_02341"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2562"/>
    <dbReference type="eggNOG" id="COG5496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119426_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="PTHR36934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR014972-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="16140" checksum="0825461F6EFCB970" modified="2011-09-21" version="1">MLLEEREKVLKTGIKGFRELMVTGENTASALGSGRLCVLATPALAGLVERTCWESVEPLLEEGETTVGTALAIKHLAPTPVGMKVWCESRLVQADGRRMVFQAEVFDESGKIGEGEHERFLVRAERFQQKADAKGNLQQGKEQEING</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9D6</accession>
    <name>F7K9D6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ThrE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02490"/>
    <dbReference type="EnsemblBacteria" id="EGN40889">
        <property type="protein sequence ID" value="EGN40889"/>
        <property type="gene ID" value="HMPREF0994_02490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2730"/>
    <dbReference type="eggNOG" id="COG3610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117642_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="156" mass="16973" checksum="EA0022B7D158447B" modified="2011-09-21" version="1">MIVTQVLAAALGTVAFALLFGVPRKYYLYCGFIGGAGWLLYCLLEPVLNATEATFFASVLVIFLSRMGAVREKCPVTIFLISGIIPLVPGAGIYWSAFYMVTDQLAEAGEAGFAAVKAAIAIVLGIVCVFELPQGVFRFVKKDQPSRIRRKSRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9L4</accession>
    <name>F7K9L4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252486.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02585"/>
    <dbReference type="EnsemblBacteria" id="EGN40984">
        <property type="protein sequence ID" value="EGN40984"/>
        <property type="gene ID" value="HMPREF0994_02585"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="34382" checksum="E31DB94F73D80E82" modified="2011-09-21" version="1">MKKKSCSGYLFILPIVILFLIFIVYPICYNFYISFYEWNGINIDKVFVGLENYKNVLRDPIMQKIIRNFVVFALFTIIIQAFFGLVFADFFIRKLKFASFYRIIFYIPVIATPAIVGNIFSKIFETNRGYLNVFLRFLHLDGLCQQWLADPKWALACIIFVNIWQWTGYSMLMYYANMLNIPQDLYEAATIDGAGQIQQFAKITFPLLRGTHYTLFIMGMLGSLKCFDLPYVLTRGGPNYATEFFSTYIYKQSFNLFKQGPASAIVMVMFAIAMVITLIQLKFYYRNDKDKELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9T2</accession>
    <name>F7K9T2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40598.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359742.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02615"/>
    <dbReference type="EnsemblBacteria" id="EGN40598">
        <property type="protein sequence ID" value="EGN40598"/>
        <property type="gene ID" value="HMPREF0994_02615"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039495_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40598.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="357" mass="40573" checksum="806E6D77D9F9B516" modified="2013-09-18" version="2">MSETGSLLSGLTSLADAKTRSISPENFHGEKGRGGMAVEGTGKECARQLGQGWKISPSVEIAGKELLVLADIEGSGIIQHIWLTCPHEDWRSLILRMYWDEEENPSIEVPLGDFFCMGWCEPGLLQSIPVCVNPNGGMNCYWQMPFRKGARITLENLTDKKSVVYYQITYSQTHVAEDAPYFHAQFSRDNPLEYKKNHVILQGAEGRGQYVGTYLAWGVNSNRWWGEGEIKFFMDGDKEFPTICGTGTEDYIGGAWNFEYPKGEYCRFSSPYSGLHQIIRPDGLYSSQQRFGMYRFHLTDPVRFDQDLHVEIQALGWRSEGRYLPLQDDIASVGYWYQTEPHRPLPPLPDVDELEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Y0</accession>
    <name>F7K9Y0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252564.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02663"/>
    <dbReference type="EnsemblBacteria" id="EGN40646">
        <property type="protein sequence ID" value="EGN40646"/>
        <property type="gene ID" value="HMPREF0994_02663"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2915"/>
    <dbReference type="eggNOG" id="ENOG5031JZ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125862_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024265">
        <property type="entry name" value="DUF3788"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12663">
        <property type="entry name" value="DUF3788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="140" mass="16557" checksum="CBE7F7C8A4FBEF7C" modified="2011-09-21" version="1">MYEKMLNKQEVPSMEDLIAYCGANGALFQELNSYLTEEWNTQTLIRFPYGNSYGWGVKHSIKSKHICDIFAEDQAFELMLRMDNRQYEAVYDDLLPYTKEVIDGKYPCGDGGWIHYRILCREHLEDAKKLLDQKCKKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA27</accession>
    <name>F7KA27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252611.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02710"/>
    <dbReference type="EnsemblBacteria" id="EGN40693">
        <property type="protein sequence ID" value="EGN40693"/>
        <property type="gene ID" value="HMPREF0994_02710"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032U6Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135496_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="122" mass="12912" checksum="EFF2BE2644BF89C8" modified="2011-09-21" version="1">MKKKNFVSMIMSTIGGILFAIGMCMCLLPQWNAFTQGVVIGIVGAVVLLAMLIVRRRMEGKPAIRLNGKAIGTMLLGIAGALAFGTGMCMVMVWELLVPGIFAGLAGMVLLLCLIPICKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA71</accession>
    <name>F7KA71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252822.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02921"/>
    <dbReference type="EnsemblBacteria" id="EGN40530">
        <property type="protein sequence ID" value="EGN40530"/>
        <property type="gene ID" value="HMPREF0994_02921"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032S3C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="100" mass="11267" checksum="8364A16F24D8D9F0" modified="2011-09-21" version="1">MVNHIVLWNFNETLTEEQKAEAGRRIKESLEAIKEKAQGVISLEVRVNELASSNKDIALLSSFESVEALNAYQIHPDHVKAGAYIKEVTCNRACFDYESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA75</accession>
    <name>F7KA75_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252826.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02925"/>
    <dbReference type="EnsemblBacteria" id="EGN40534">
        <property type="protein sequence ID" value="EGN40534"/>
        <property type="gene ID" value="HMPREF0994_02925"/>
    </dbReference>
    <dbReference type="GeneID" id="29724482"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3192"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040024_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="538" mass="59818" checksum="98CDBC4534E177F1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAF0</accession>
    <name>F7KAF0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252677.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02776"/>
    <dbReference type="EnsemblBacteria" id="EGN40385">
        <property type="protein sequence ID" value="EGN40385"/>
        <property type="gene ID" value="HMPREF0994_02776"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3037"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="129"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="35434" checksum="9DA0A05D840CA9C3" modified="2011-09-21" version="1">MVNRLFGICYQLMKREKIPARELAERYEVSVRTIYRDVEMLSMAGVPVFASKGRGGGISLMEHCVIDKMFVNEDEKAQILAALESLRETAPSDNTELLQKLGDFFQTSGSNWVSIDFSDWSGRQEMLFSLLKKAILQSRVIAFDYYSADGKMEHRIAEPIQLCFKSHNWYLRAWCRNRQDMRTFKVLRIKRPEILDESFSSRRICGRNAEPAPAEQEDKKISACPELTTVILEIEGSQAYRIYDSFGEEEIFPEENGDFLIRTAYSIDDWVYGVILSYCPYIKVHEPVWLREKLHHILQKSSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAF8</accession>
    <name>F7KAF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252685.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02784"/>
    <dbReference type="EnsemblBacteria" id="EGN40393">
        <property type="protein sequence ID" value="EGN40393"/>
        <property type="gene ID" value="HMPREF0994_02784"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3047"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_11_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003562">
        <property type="entry name" value="Mutator_MutX_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01402">
        <property type="entry name" value="MUTATORMUTX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="176" mass="20396" checksum="9F92397851652006" modified="2011-09-21" version="1">MKSPVTTLCYIEQDDKYLMLHRIKKKNDLNEDKWVGIGGHAEEGESPEDCLLREAMEETGLSLTSYQFRGLVTFVSDKWGTEYMCLYTADGFEGEMIDCNEGCLEWIAKSKIPELNLWTGDLIFFRLLEEKVPFFSLKLRYEGDLLAEWQLNGKDMTGTVLSDEKWKEILDSLRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAK9</accession>
    <name>F7KAK9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02835"/>
    <dbReference type="EnsemblBacteria" id="EGN40444">
        <property type="protein sequence ID" value="EGN40444"/>
        <property type="gene ID" value="HMPREF0994_02835"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3103"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_73_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="575"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="857"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="857"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="952" mass="107819" checksum="48EF0DC911CEF818" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAM9</accession>
    <name>F7KAM9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="8" type="ORF">HMPREF0994_02855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252756.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02855"/>
    <dbReference type="EnsemblBacteria" id="EGN40464">
        <property type="protein sequence ID" value="EGN40464"/>
        <property type="gene ID" value="HMPREF0994_02855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3123"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_3_3_9"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="191" mass="21621" checksum="89B0225136603C8E" modified="2011-09-21" version="1">MNNRKQNIPKRIIWLPDILLILAGILLDQFTKHLAVVYLKGSQPVSLIPGVLELRYLENRGAAFGMMQGAKVFFLIITPVILAAVIYALIKMPSDGKFRVLHILLDCVAVGAVGNMIDRIRLDYVVDFIYISLIDFPIFNVADMFVSIACVVGAILILFSNKYKDEDFRFLSFKQKQSIPKEEDSPENEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAY1</accession>
    <name>F7KAY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40330.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360268.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03010"/>
    <dbReference type="EnsemblBacteria" id="EGN40330">
        <property type="protein sequence ID" value="EGN40330"/>
        <property type="gene ID" value="HMPREF0994_03010"/>
    </dbReference>
    <dbReference type="GeneID" id="29728212"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052940_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40330.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="365" mass="40953" checksum="48EF56596A1802DB" modified="2013-09-18" version="2">MMLLGTELEKLWKRPALWIGFAVSMLVGVFLTWSMLPMVYTGEGTISGLKAAAYNRRLAAEYEGYLTEEKTEAIISRFGFARYDEAGGCVYGNFLNRFVTEKMTDYSGDKRRAERLIPLSAKDGWLGACTYKDHIYFAYTEGWDELWEIFMGLAVVWGITLVVLLSPVYSSDRMLRTAPVIRASAEGRRKMVVARLAASWIVAAGGYLLIGGLFFLICGLIYGFEGLKANMLCLGAMPYIWPESVTVGAFWAGACLPRAVLGITVLVFFLSGISAYCGRSLTSVCLSALLFAFPVIRKMLWIRTFLTPLFSLLVNGMPFYMMIPLYEDGRKAFWILQAVVAMLFCLAGLWMVYSGWCRNRKEYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB16</accession>
    <name>F7KB16_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252946.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03045"/>
    <dbReference type="EnsemblBacteria" id="EGN40222">
        <property type="protein sequence ID" value="EGN40222"/>
        <property type="gene ID" value="HMPREF0994_03045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3326"/>
    <dbReference type="eggNOG" id="COG1395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118960_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="194" mass="21828" checksum="91CDDF3B4909A0E0" modified="2011-09-21" version="1">MNHYITGNTIRVLREKKQITQKELAQILGVSDKAISKWETAKGYPDISLLEPLAAALDISVAELLSGDYVTNQNKMGNMLRSVFYICPVCGNVIHAMGKCVVSCCGITLLPEETEETDSAHTIAIEQVEDESYVTIDHEMSKSHHISFIAWVTSGRLELLKLYPEQNAEGRFRLRGHGCLYIYCNKHGLMRQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBA7</accession>
    <name>F7KBA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase RecJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253037.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03136"/>
    <dbReference type="EnsemblBacteria" id="EGN39966">
        <property type="protein sequence ID" value="EGN39966"/>
        <property type="gene ID" value="HMPREF0994_03136"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3429"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="229"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="35603" checksum="EEC4CBE2149C0470" modified="2011-09-21" version="1">MKLLEECKQAKRIGISGHIRPDGDCIGSCMGLYLYLKKVRPDADIHIFLEKPADIFSCIRGVEEIDSDYGKQEKFDVFFCLDTASDRLGQAEEYFCTADKKINIDHHVSNSGCGDVNYVIPEASSTSELIYNLIDGEQLDEEIAKALYIGIIHDTGVFQYSNTAPETLRAAAHLISFGFDFSRLIEETFYEKTYLQTQILGRALLESIRFLDGKCVVSVLDKKTMDFYEATSQDLEGIVSQLRSIKGVECAIFMYETGVLEYKVSLRSGGRINVSKIASYFGGGGHVRAAGCTMNGTSHDVINNLSLHIEKQFIEEQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBH6</accession>
    <name>F7KBH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253111.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03210"/>
    <dbReference type="EnsemblBacteria" id="EGN40040">
        <property type="protein sequence ID" value="EGN40040"/>
        <property type="gene ID" value="HMPREF0994_03210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3506"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="375" mass="41390" checksum="85F0523C44CD5C47" modified="2011-09-21" version="1">MKNERTEKEREFSYWLCNIEGIGRITVLRLIREAGSAEKVYGMEEKALAGMLRPSQLMNFLKARQEKDVKREYQKLWSRGIRFIPLSDPEYPRRLSSIPDPPAGVYVRGELPEETKPAVAVIGARMCSEYGRYVASWFASALSRAGVNIISGLARGIDGISQEAAIRAGGKTYAVLGCGVDICYPEENRKIYDRIPGQGGILSEFPPGMLPKAAHFPVRNRIISGLSDVVLVVEARMKSGTLITVDMALEQGKEVFVVPGRITDALSSGCNELIRQGACMACSPDVLLEELAKNRKKFRKNAAASDGPAEEEPAEDGVKSFLDFTPRAADNIYEEMKKKGISMSLPQLLQNLLELQMEGAVKQEGGYFFLSGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBX7</accession>
    <name>F7KBX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253151.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03250"/>
    <dbReference type="EnsemblBacteria" id="EGN40080">
        <property type="protein sequence ID" value="EGN40080"/>
        <property type="gene ID" value="HMPREF0994_03250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3550"/>
    <dbReference type="eggNOG" id="COG5485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="15483" checksum="554F838861A87B87" modified="2011-09-21" version="1">MEKKDIVKYFYETIVSENLLEELPQFIAEDCVVKVGEQIIPVGIDGMKQHLVDVKKTYPDYTMKILKQYADGDYVISEFIMEGTHEGEWIGIKPTHKRLSFTGVDIDKVVDGKIAEHGGAVNTFDTLYEENLIKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC18</accession>
    <name>F7KC18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03397"/>
    <dbReference type="EnsemblBacteria" id="EGN39904">
        <property type="protein sequence ID" value="EGN39904"/>
        <property type="gene ID" value="HMPREF0994_03397"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545659_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="173" mass="19870" checksum="C41659C697E57068" modified="2011-09-21" version="1">MNINNNILKAYLKNCFFINGTAYAGKSTMCKMLAEKYHLLLCGENYGLDRMLQIITPEEQPNLSYFNTMKDWQEFVNRTPDEYLAWIRGNSYEAADFEIAELIRLSGDRKTIVDTNIPLDILRQIADYNQVAVMLSPQSTGFLTGKMKRSSSCYLRSGSPRIRRKPWGTFGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCJ9</accession>
    <name>F7KCJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253486.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03585"/>
    <dbReference type="EnsemblBacteria" id="EGN39494">
        <property type="protein sequence ID" value="EGN39494"/>
        <property type="gene ID" value="HMPREF0994_03585"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50337R1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081253_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="216" mass="26101" checksum="767D2D8C0FC4A43D" modified="2011-09-21" version="1">MNHIEVKYIKTCYDYYEYYWVIDDEPITVYLDRNNTGSLSAFGSLLGLLPAWSGELIWQWENDFIWEMADSREELNVPVLVCEDDCDLSCIVIVAHIRKEKNAVYWDRIGVLDKSNINAQDYGQSGILCLEAYTDEDWEKYGDNIALEEYGSSEYWKWVSENSYEEHIRRLRNYFKPYMQNGQNMEWIWETGWQFEREEYEIMTERYREIAINRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCK1</accession>
    <name>F7KCK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YbhB/YbcL family Raf kinase inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253488.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03587"/>
    <dbReference type="EnsemblBacteria" id="EGN39496">
        <property type="protein sequence ID" value="EGN39496"/>
        <property type="gene ID" value="HMPREF0994_03587"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="165" mass="18762" checksum="DAE13546559C64A2" modified="2011-09-21" version="1">MTITEADSNTLKVTSNAFKDGQYMPVDYTGFGKDMSPDFRLHNLSKKAVSIAIIMDDLDIPFLPAYNHWLIWNIPAMQEIPEKIPHGPEIPGLGNARQGIAYGKNKYRGPKQPVFIRNMHRYVFRIYVLDCFLDLTAASVKKDLTEAMEGHVLQQGSIMGKYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD02</accession>
    <name>F7KD02_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253632.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03731"/>
    <dbReference type="EnsemblBacteria" id="EGN38895">
        <property type="protein sequence ID" value="EGN38895"/>
        <property type="gene ID" value="HMPREF0994_03731"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4073"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="138"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="300"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="411"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="777"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN38895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="848" mass="95794" checksum="B46B6F2EEE70BAF9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDC9</accession>
    <name>F7KDC9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253763.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03862"/>
    <dbReference type="EnsemblBacteria" id="EGN38627">
        <property type="protein sequence ID" value="EGN38627"/>
        <property type="gene ID" value="HMPREF0994_03862"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4205"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="350" mass="38026" checksum="F99F25F20C32A432" modified="2011-09-21" version="1">MEKMRMRGATLPGNSTVEMKDMEIPKPGHGQVLIQTKATTICGSDIRCIYREHVGKGPEGYIPGMVAGHEPCGVIVEEGEGLRRFKKGDRVIVYHISGCGVCNDCRRGYYISCKSRFRQAYGWQRNGGMAPYILAEEKDLIALPDELTYKDGAQVACGFGTVYEAIEKIGVCGNDAVLVTGLGPVGLAALMLAKAMGANMLIGVEMNDYRIGLAKELGLVDYVFKPDEAMEGIMKVTNGNGVERSIDASASDPGRQLAIRATREWGKIAFVGEGGTCSFTPSPDIIHGQKTIYGSWVTSLWRMEELVERLVRWGIHPEDLITDEFPIEKAGEAYALMAGGNCGKVAVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDF2</accession>
    <name>F7KDF2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mini-ribonuclease 3</fullName>
            <shortName evidence="2">Mini-3</shortName>
            <shortName evidence="2">Mini-RNase 3</shortName>
            <ecNumber evidence="2">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mini-RNase III</fullName>
            <shortName evidence="2">Mini-III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mrnC</name>
        <name evidence="4" type="ORF">HMPREF0994_03885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MrnC RNase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253786.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03885"/>
    <dbReference type="EnsemblBacteria" id="EGN38650">
        <property type="protein sequence ID" value="EGN38650"/>
        <property type="gene ID" value="HMPREF0994_03885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4228"/>
    <dbReference type="eggNOG" id="COG1939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091169_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005520">
        <property type="entry name" value="UCP005520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN38650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="146" mass="16598" checksum="E6648ACE2139C44A" modified="2011-09-21" version="1">MEESISLLAQIKREFGLGEVDLRTYSPLTLAFVGDCIYDLIIRTVVVECHNASPNRLHKEKSRLVKAQTQALMGDAIQSFLTPEEQAVFRRGRNAKSYTTAKNATVGDYRKATALEALYGYLYLDDRMDRLMELIKISLNELDIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDV4</accession>
    <name>F7KDV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253934.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04033"/>
    <dbReference type="EnsemblBacteria" id="EGN37722">
        <property type="protein sequence ID" value="EGN37722"/>
        <property type="gene ID" value="HMPREF0994_04033"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4398"/>
    <dbReference type="eggNOG" id="COG4954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121942_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018988">
        <property type="entry name" value="DUF2000"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017021">
        <property type="entry name" value="UCP033763"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09391">
        <property type="entry name" value="DUF2000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033736">
        <property type="entry name" value="UCP033763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="140" mass="15200" checksum="CB207D27331C8769" modified="2011-09-21" version="1">MELQDRKCVMILNEELPAGVLANTAGILGITLGKKVPENIGPDIYDKDGREHLGIVALPVPVLKADKEKLKAIRERLYQPEFAECVVVDFTDVAQCCQNYEDYIAKAAGAGGEELTYLGIGICGSKKLVNRLSGSLPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE04</accession>
    <name>F7KE04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04083"/>
    <dbReference type="EnsemblBacteria" id="EGN37119">
        <property type="protein sequence ID" value="EGN37119"/>
        <property type="gene ID" value="HMPREF0994_04083"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4456"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN37119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="360" mass="38438" checksum="D83FCFED6D58A978" modified="2011-09-21" version="1">MKSIKKRMAGRRDSLISFGIVILAYIVIQIMISTGNISSSLKGQLVPICAYIVMAVSLNLTVGFLGELSLGHAGFMSVGAFTGIVVTTSLAQAIPSAPLRLAIAMIIGGIFAAVAGVIVGVPVLRLKGDYLAIVTLAFGEIIKNIINVLYIGMDGKGLHFSLLEQRFALEDGGKMIINGPMGVSGVTKISSFTSGIILILITLFLILNLVHSRTGRAVMSVRDNRIAAESIGISATRYRLLAFVISAAFAGMAGTLYAMNFSTVTANKFDFNTSILVLVFVVLGGLGNIWGSIIAAALLTVLPELLRGLNDYRMLIYAILLIVMMIFNNSGLKTHLLEKRAARRAGDPQKKTELSDKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE41</accession>
    <name>F7KE41_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="5" type="ORF">HMPREF0994_04120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254021.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04120"/>
    <dbReference type="EnsemblBacteria" id="EGN36913">
        <property type="protein sequence ID" value="EGN36913"/>
        <property type="gene ID" value="HMPREF0994_04120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4493"/>
    <dbReference type="eggNOG" id="COG0717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="65"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="96"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN36913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="178" mass="19716" checksum="A4058C351D9D57DC" modified="2011-09-21" version="1">MILSDKTILKMLENKSLTITPVEKEQIQPASVDVRLGNTFSIVEDMSRGILSLDNEIVYKTITADTYVLLPGQFVLASTMEYFELPDNLTAFVEGRSSLGRIGLFIQNAGWVDPGFRGEITLELFNANRCAIELKAGRRVGQLVFAQLDDTALNPYAGKYQGQRGATGSRVYMDIEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE42</accession>
    <name>F7KE42_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04121"/>
    <dbReference type="EnsemblBacteria" id="EGN36914">
        <property type="protein sequence ID" value="EGN36914"/>
        <property type="gene ID" value="HMPREF0994_04121"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3389988_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="32" mass="3598" checksum="4B2E89E8B26B633A" modified="2011-09-21" version="1">MGIGKSLVDAAVHWEKERSLNGISLENQDWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE91</accession>
    <name>F7KE91_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN36963">
        <property type="protein sequence ID" value="EGN36963"/>
        <property type="gene ID" value="HMPREF0994_04170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4545"/>
    <dbReference type="eggNOG" id="ENOG5032JI0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_213017_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="49" mass="5345" checksum="856CA69C7CFA7377" modified="2011-09-21" version="1">MWDNFLITLSIMGKGMVGIFTVIIIISLVVALMCRLGSGKKTDEKKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEL2</accession>
    <name>F7KEL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase, family IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254192.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04291"/>
    <dbReference type="EnsemblBacteria" id="EGN36103">
        <property type="protein sequence ID" value="EGN36103"/>
        <property type="gene ID" value="HMPREF0994_04291"/>
    </dbReference>
    <dbReference type="GeneID" id="29724428"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="230" mass="26640" checksum="111D65178205A51B" modified="2011-09-21" version="1">MGEIMKKVLFWDFDGTIIYPNESFLDALDRTVREFGFEIEREKIRQFLHTACTWYIPEVSYPDEVGERWWESLFGKFMSFFRECGITESNWTQMNGYFKGCILDFRGYRLYEDAEEVLGKCREMGYENFMISNNFPEIADIVKALGLGNYFKDYIVSSEIGYEKPRAEIFQHALKKAGFPEVSYMIGDNPIADIQGGRNAGMRTILVHAAVGSEADWICEKLIDIPALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEP9</accession>
    <name>F7KEP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase, NADH/NADPH, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN35638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254229.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04328"/>
    <dbReference type="EnsemblBacteria" id="EGN35638">
        <property type="protein sequence ID" value="EGN35638"/>
        <property type="gene ID" value="HMPREF0994_04328"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4724"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_1_9"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="153"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="497" mass="55242" checksum="CFBDBFD9229462BC" modified="2011-09-21" version="1">MGKPTGFMDYDRKVSRAEEPASRIKHFNEFHQHLSREEQQLQGARCMECGVPFCQSGMMLCGMASGCPLHNLVPEWNDLVYTGNWEQAYERLKKTNNFPEFTARVCPALCEAACTCGLNGEPVSTKENEYAIIENAYEKGYAAPKPPKQRTGKKVAVIGSGPSGLAAADQLNKRGHTVTVYERSDRIGGLLMYGIPNMKLEKDIVQRKVKIMEEEGVTFLTGIDVGKDIKPSQLLKEYDRIILACGASNPRDLNAPGRDAKGIYFAVDFLTANTKSLLDSNFTDGKYVETKGKNVIIIGGGDTGNDCVGTSIRHGCKSVTQIEMMPKAPDQRAEDNPWPEWPKICKTDYGQEEAIALYGHDPRIYESTVKEFIKDKNGNLKAVKIVKLKQEKDPKTGRMNMKEIPDTEQILDADIVLIAAGFLGSQKYITDAFKVELNARTNVKTEDGKYKTNADKIFVTGDMHRGQSLVVWAIREGREAAREVDESLMGYTNVSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KET1</accession>
    <name>F7KET1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254261.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04360"/>
    <dbReference type="EnsemblBacteria" id="EGN35670">
        <property type="protein sequence ID" value="EGN35670"/>
        <property type="gene ID" value="HMPREF0994_04360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4760"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="31390" checksum="F1EB1C0E7FB5DA5D" modified="2011-09-21" version="1">MRAKKIRKVILITVLLLMLIVILIPLVWCIVLSFDRKALSTLPEFSLVPHEFSLFNYQVAFNTIPLVRYYLNTIFVTVVHTFLAVFFALMCGYAFAKGKFVGKQFWFIFMLAVMMIPFESRMVPLYLQYKSWGLLDTYAPLLMGACAYVYGIFFAKQNIEAIPDSLRESAYIDGASEWRIFLQIIIPLSKPLIATLSILQILSNWNSYLWPLVVIRSSEKQLISVGVSVFNAQQDSIYYGPRMAVAVISAIPLSIMFLFLQKYIVQSVAVSGIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEU9</accession>
    <name>F7KEU9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0397 protein HMPREF0994_04383</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0397 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254284.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04383"/>
    <dbReference type="EnsemblBacteria" id="EGN35693">
        <property type="protein sequence ID" value="EGN35693"/>
        <property type="gene ID" value="HMPREF0994_04383"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4782"/>
    <dbReference type="eggNOG" id="COG4720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120023_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01572">
        <property type="entry name" value="UPF0397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022914">
        <property type="entry name" value="UPF0397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="184" mass="19299" checksum="7E1D27053A82FDFE" modified="2011-09-21" version="1">MKLKFGIKEVVAIGIGTALFIVLTNVQVPFGIIPNTALQSRVAVLTFFSAVFGPIVGGAIGLIGHALGDALFYGSVWWSWVFPDALFGILMGLFAAKYAIKDGGFNGKAIALFNVVQIIANALAWILLAPVLDILIYAEPANKVFTQGVLAFIGNIVVAGVLGTLLAVAYSKIGARSSSLSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEZ0</accession>
    <name>F7KEZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254327.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04426"/>
    <dbReference type="EnsemblBacteria" id="EGN35736">
        <property type="protein sequence ID" value="EGN35736"/>
        <property type="gene ID" value="HMPREF0994_04426"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4834"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="327"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="610" mass="68682" checksum="93FEC320995FD31F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF18</accession>
    <name>F7KF18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35769.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04459"/>
    <dbReference type="EnsemblBacteria" id="EGN35769">
        <property type="protein sequence ID" value="EGN35769"/>
        <property type="gene ID" value="HMPREF0994_04459"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024197_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35769.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="729" mass="82912" checksum="857F624C659ED65E" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF26</accession>
    <name>F7KF26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254368.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04467"/>
    <dbReference type="EnsemblBacteria" id="EGN35777">
        <property type="protein sequence ID" value="EGN35777"/>
        <property type="gene ID" value="HMPREF0994_04467"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4879"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048744_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="34196" checksum="15CE06436DEE01D3" modified="2011-09-21" version="1">MKNKEINIRDPFVLVHDGHYYLYGTRAKTCWGKADGFDCYVGTDLENWEGPFEVFHRPEGFWADKNYWAPEVHFYEGTFYMFATFNSEAVEKKGPMILKADNPLGPFVLHSEGKITPDAWNCLDGTLYVSPEGIPYMVFCHEWQDIGDGAVCCVELTKDLKRPAGDVRTLFTASQGRPWVRKIVHDRFPGDNYVTDGPFLYRLKGGELLMLWSSFGEYGYVEAISRSDNNDITGNWVPDEELLFERDGGHGMLFATLDGKLMLTLHSPNETPLERPAFYEMEERDGELAVKAVSPQTDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFI0</accession>
    <name>F7KFI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea ABC transporter, permease UrtC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04609"/>
    <dbReference type="EnsemblBacteria" id="EGN35056">
        <property type="protein sequence ID" value="EGN35056"/>
        <property type="gene ID" value="HMPREF0994_04609"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5032"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="377" mass="40712" checksum="66D99D9335A7EFD3" modified="2011-09-21" version="1">MKRQTKSLSEEKGKHGIQGTTVLAVLLFIFLATLPFYMPMFRVSLFGKYMCFAIVALGLDMIWGYTGILSLGHGVYFGLGAYCMAMYLKLEASGGALPDFMSWSGLTELPGFWKPFQNPVFAVAMALLVPVVLAVLIGYLTFIHKIRGVYFSILSQALAMIFGTLLVGSQAYTGGSNGLTNFSTIFGKSLNAPLTKIMMFYATLTGLVLVFALCRFLTNRRIGKVFLAIRDGESRAGFVGYNTAVYKVFVYALSAFIAGLGGALYVTQVGIISPSEVGIVPSVEMIIWVAIGGKGTLAGPILGALAVNGLKTAASENFPELWSYFIGILFVVVILWLPGGFVSLKEIPRKIRHKMSAGKKNTETGEDKKTAAEQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG64</accession>
    <name>F7KG64_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="10" type="ORF">HMPREF0994_04847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254748.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04847"/>
    <dbReference type="EnsemblBacteria" id="EGN34474">
        <property type="protein sequence ID" value="EGN34474"/>
        <property type="gene ID" value="HMPREF0994_04847"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5291"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="716"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="514"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="333"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="792" mass="87397" checksum="2FC3BCDE67FDF322" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGR6</accession>
    <name>F7KGR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermidine/putrescine transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254946.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05045"/>
    <dbReference type="EnsemblBacteria" id="EGN33754">
        <property type="protein sequence ID" value="EGN33754"/>
        <property type="gene ID" value="HMPREF0994_05045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5511"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="256" mass="29015" checksum="D28BE09F110DA7BB" modified="2011-09-21" version="1">MLSLQHIKKSYDGVPVLQDITLDIKDGEIVSILGPSGCGKTTLLNVILGITDADEGKILFHEEDITHEPMEKRGFNIVFQDYALFPNLNVYQNITYGLRNKPGISSEEEVKELIRLLGLEEHLDKKIDQLSGGQKQRAALARTMVMKPRILLLDEPLSALDGVIKESIKDRIKTIAREYHLTTIIVTHDPEEALTLSDRVLIINEGGISQYDEPAEIIHQPKNSFVRKFILNQLEIKRNNIYSLFEENPKESYLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGW4</accession>
    <name>F7KGW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254994.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05093"/>
    <dbReference type="EnsemblBacteria" id="EGN33126">
        <property type="protein sequence ID" value="EGN33126"/>
        <property type="gene ID" value="HMPREF0994_05093"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5566"/>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131526_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="14682" checksum="D06AD0F213DCB30B" modified="2011-09-21" version="1">MDITEGIKKIFLAGVGAVATTGEAAKNLIDNLVEKGELTVEQGKVLNEELKRNTKEKINKHVTVNVVNEFKDVFSAVDKMSREELEALKEKLESLKDAAPAEEEEAKEDCGCEEECSCEEKTETCDGENCDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGX7</accession>
    <name>F7KGX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33139.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05106"/>
    <dbReference type="EnsemblBacteria" id="EGN33139">
        <property type="protein sequence ID" value="EGN33139"/>
        <property type="gene ID" value="HMPREF0994_05106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33139.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="217" mass="24351" checksum="BAD99ACBB7BBBBCC" modified="2013-09-18" version="2">MQKIKKIVDLSHELKNGTVVYPGDPVVDITVATLKEKDGYNLSNVHIGSQSGSHVDAPYHFKNDGLTVDRMELSYFMGNALVIDASDKGEFEEITLEDVKKYDRQMEKADIVLFRTDWYQYEGHDKFFRHPYLSAEAGAYLLNRGIQTLAIDTINLDRTGGTKFPVHEMYAEAGGLIAENLAHFDKIEFDEPFVIFLPLKLTGVDGSPVRAAAVSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGY1</accession>
    <name>F7KGY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255011.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05110"/>
    <dbReference type="EnsemblBacteria" id="EGN33143">
        <property type="protein sequence ID" value="EGN33143"/>
        <property type="gene ID" value="HMPREF0994_05110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="155" mass="18697" checksum="4723774AD0C2875A" modified="2011-09-21" version="1">MIAKIYQLFFQELIRYVTKMTCDKTAAEDIVQETFLRAMEHAEILDDMDERQCRSWLYKTSRNIFIDKVRRESAYPEAEEKTETQDDLSQIEVRQLCEKLPEEERILFIKRYFEGFDSTQLSAMYKLPPSTIRSRLASARRKLRMYYPELENQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH19</accession>
    <name>F7KH19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255056.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05155"/>
    <dbReference type="EnsemblBacteria" id="EGN33188">
        <property type="protein sequence ID" value="EGN33188"/>
        <property type="gene ID" value="HMPREF0994_05155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5635"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="255" mass="28178" checksum="24B68C2D273FF6A6" modified="2011-09-21" version="1">MGRIIAIANQKGGVGKTTTAINLSAALAAKGKKVLVIDTDPQGNTTSGFNIDKNNLDNTIYELMLGECSVQDCLIKEVVPNVTVLPSNVNLAAAEIELIGVDKKEYILKNEVDWIKDQYDFIIIDCPPSLNMLTVNAMTTANTVLVPIQCEYYALEGLSQLIHTVNLVRERLNPQLQIEGILFTMYDSRTNLSMQVVDNVKKNLNQKIYKTVIPRNIRLAEAPSYGLPITMYDPKSAGAESYMALANEVIKRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH21</accession>
    <name>F7KH21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255058.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05157"/>
    <dbReference type="EnsemblBacteria" id="EGN33190">
        <property type="protein sequence ID" value="EGN33190"/>
        <property type="gene ID" value="HMPREF0994_05157"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5637"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101313_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027981">
        <property type="entry name" value="DUF4446"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14584">
        <property type="entry name" value="DUF4446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="169" mass="18965" checksum="EDAE910A75E9626D" modified="2011-09-21" version="1">MSSGLMESMGLGGLDIAYVLIGMLVFILVLLVLIIIQFSKVSKLQKKLAKFMKGKEAKSLEEEIEGLYKDNDFIKKESDKNRKDIRDIQKRLEYCYQKVGIVKYDAFSQMGGQLSFCIALLNEKDDGFILNSVQSSDGCYTYTKEVKKGECAITLGAEEKEALDKAIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHT3</accession>
    <name>F7KHT3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05422"/>
    <dbReference type="EnsemblBacteria" id="EGN32863">
        <property type="protein sequence ID" value="EGN32863"/>
        <property type="gene ID" value="HMPREF0994_05422"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5926"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357437" description="SBP_bac_5 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="138"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="672" mass="76076" checksum="B7060308C7F81712" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHY3</accession>
    <name>F7KHY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255322.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05479"/>
    <dbReference type="EnsemblBacteria" id="EGN32920">
        <property type="protein sequence ID" value="EGN32920"/>
        <property type="gene ID" value="HMPREF0994_05479"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="35346" checksum="D51DD9EA3015FFF7" modified="2011-09-21" version="1">MFLELKGIPQFVDCGKLVSTLPFLHADRTNAEYLLLMGIKGELHIRVGEIPCTITPRDIMIILPGTPISGLIPSRQLTYFWCHFNMSEKPQFLSQQEAISRYQVMLQPGDTDSPPLIPQTFHLINSSRAIIFSQQLLNYRCCPEYPGSILHNLLSCLLIELSTQAADSFSSITIGKNHQRLQEILQWIRVNACMKITVSEIADRFNYNPDYLSHLFHEKLGISLKHYIIRVKLEIVKEVLISSDKSIKEIARYVSFDDEKYLMRLFKQNEGVTPSEYRNACSRTKFNTNLRVSKRIDTRWVSFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI14</accession>
    <name>F7KI14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006777875.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05516"/>
    <dbReference type="EnsemblBacteria" id="EGN32957">
        <property type="protein sequence ID" value="EGN32957"/>
        <property type="gene ID" value="HMPREF0994_05516"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503377Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199700_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="64" mass="7532" checksum="6AF5B05B12D97D36" modified="2011-09-21" version="1">MTRFTDSPYERMMTRRPEGGKETSRPPSLPQSHPCYGCGNYGSPCVGICHREMERWLKERKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI66</accession>
    <name>F7KI66_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05545"/>
    <dbReference type="EnsemblBacteria" id="EGN32370">
        <property type="protein sequence ID" value="EGN32370"/>
        <property type="gene ID" value="HMPREF0994_05545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6061"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="36358" checksum="8A26E8F1B6F2D41C" modified="2011-09-21" version="1">MNWAVVGVGNIANVFMKAIQHIPDVKVLAAYGRNREKLDAFCDKWNIKERYTDYEQLYKQSSVSVIYLATPHIVHFEHTMSALEHGKHVLCEKPMAMSFEETEALVYAARKNKVFLMEAMWTRFFPINKWLMEFIRSEEFGKPVNVNADFSFEYPYDKDYRFFRRDLGGGCMRSAGIYPLAYACMVFGCLPDEIKAIAQMKNEVDLRTAALFRFPKDCTAEIYTGFQGESQCMANIAFEKGTVVIPEFIHPDTAIIKPCGGEEKRISLLYEEPGLQFEIEHAEDCIRMGKKESPIMPLNESIGIARAIDLVYEQVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIC5</accession>
    <name>F7KIC5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydroxylamine reductase</fullName>
            <ecNumber evidence="7">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hybrid-cluster protein</fullName>
            <shortName evidence="7">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hcp</name>
        <name evidence="8" type="ORF">HMPREF0994_05604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="7">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05604"/>
    <dbReference type="EnsemblBacteria" id="EGN32315">
        <property type="protein sequence ID" value="EGN32315"/>
        <property type="gene ID" value="HMPREF0994_05604"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6121"/>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038344_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="7">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="536" mass="59052" checksum="FC1B0068F0AD7875" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIF0</accession>
    <name>F7KIF0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255436.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05629"/>
    <dbReference type="EnsemblBacteria" id="EGN32340">
        <property type="protein sequence ID" value="EGN32340"/>
        <property type="gene ID" value="HMPREF0994_05629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066636_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="76"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="314" mass="36777" checksum="B8E3872BE65249C8" modified="2011-09-21" version="1">MGKIDISLSSYLSHPPVFADLFNAWLYGGRQVIDYHGLRQEDPVQNRPEYSAAYKHVRDVVKMYYQDGMELVLLGIENQEKIDYTAPVRIMQYDGADYQKKVRRVEEENRKRLGLKTGFPAFFPDDRITPVITLLLYFGEEEWKRPRRLHDLLRFPEESDRLRSFVPDYPIHVLSVRRDMDISLLHTELRQVFGFLQCQEDRKALKKYVKENEHVFSRLSKDAALFLAAAAKGTQILSALNVKEESCNMCKALDDLYNDGVNQGKSQGLELGEEYFAALSQKLLADFRIDDLQKAIKNKEYRKKLYQEYRIERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIT7</accession>
    <name>F7KIT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000013">
        <property type="protein sequence ID" value="EGN31907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569233.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05766"/>
    <dbReference type="EnsemblBacteria" id="EGN31907">
        <property type="protein sequence ID" value="EGN31907"/>
        <property type="gene ID" value="HMPREF0994_05766"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6304"/>
    <dbReference type="eggNOG" id="ENOG5032SDU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2859747_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026990">
        <property type="entry name" value="TnpW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14202">
        <property type="entry name" value="TnpW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="62" mass="6743" checksum="9E3244943DC504C1" modified="2011-09-21" version="1">MTETKQTSTTKTDRRPDCVTEIRMGNSVLTVSGFFKQGATDTAADKMMKVLEAEAATQKTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ91</accession>
    <name>F7KJ91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255701.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05925"/>
    <dbReference type="EnsemblBacteria" id="EGN31553">
        <property type="protein sequence ID" value="EGN31553"/>
        <property type="gene ID" value="HMPREF0994_05925"/>
    </dbReference>
    <dbReference type="GeneID" id="29729130"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="362" mass="42688" checksum="095DB7A3D95928AB" modified="2011-09-21" version="1">MLFESFKQGINLGGFLSQYELIADAGSEESLHSHFETFITEDDIRRIASWGFDHVRIPLDGYLFFDTEKKLLKDEPLEYLDRCVDWCAVYGLNAVIDLHNIRGHIFGEMDSPTPLMTEPELRDDFCRFWGNMAEHFKGYHKTRLMFEMFNEITDSTGYMWNKLYKQAVKEIRKADSERWILVGTNFVNSVGYLDRLDLLEDPYVFYNFHYYEPNVFTHQKAHFSEEFCTWNQTLAYPGDMTDYITFLDTHKEFKKEHPLMSKDTVCNDKKLMQKLLSDAEKFMEYSGRELYCGEFGVIDSAPEEEAVKWIRDFITICNSLKIGHAMWNYKCLDFELVDMNNQVVRPEILEVLKELNSLAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJG7</accession>
    <name>F7KJG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255772.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN31350">
        <property type="protein sequence ID" value="EGN31350"/>
        <property type="gene ID" value="HMPREF0994_05996"/>
    </dbReference>
    <dbReference type="GeneID" id="29724134"/>
    <dbReference type="HOGENOM" id="CLU_1883079_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="135" mass="15462" checksum="5B1EACE93A817078" modified="2011-09-21" version="1">MYINNVTAGNDTVTEMQILKNKYNLTEQELCVLFDIESTNISDGKIVSKQKLMSLDTETAAISLLNTISDDARLTAYIDELYARYHLNNSILSKISGIEEHIINDLYNNPELIPFEIKYSLCIKVVYLLFLFSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJM6</accession>
    <name>F7KJM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255836.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06060"/>
    <dbReference type="EnsemblBacteria" id="EGN31414">
        <property type="protein sequence ID" value="EGN31414"/>
        <property type="gene ID" value="HMPREF0994_06060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6636"/>
    <dbReference type="eggNOG" id="COG0530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007948_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="176"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="316" mass="33558" checksum="0754CB951C16677E" modified="2011-09-21" version="1">MISVILLFILGLFLICFGGDKLVDSSVALAKKIGIPQIVVGATIVSIGTTLPEILVSTTAAFDGSAAISAGNAFGSIICNTALIAGFGQLIRPAKKVEFTSLAWRCLFFFATILALTAYGWFTGSFDRVSGIVLLCLFVLYAWLNMARAKSEEEVTVENEESLEELKKISLPRNLMMLAFCAVLLFLGANLLVDNGIIIAGYLGVPERVIAVTAIALGTSLPELVTTIMSLVKGCENVGLGNIIGANILNLLLVIGIPATITGMKLETQTVRVDAPLGALLMGILILPILFRKKGSRVQGAVLLGCYALYCAFNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJS9</accession>
    <name>F7KJS9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255884.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN30734">
        <property type="protein sequence ID" value="EGN30734"/>
        <property type="gene ID" value="HMPREF0994_06108"/>
    </dbReference>
    <dbReference type="GeneID" id="29725429"/>
    <dbReference type="eggNOG" id="ENOG50328PE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560971_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="171" mass="18493" checksum="C594E89FF403B019" modified="2011-09-21" version="1">MAYHAIIEGSSLTVYRQSDCASNSKIGTLYSGEVFTFIKEHNGYFGHYEIRFLNSNGQYGIGFIDIGSGFGNLAYSGQSVTESNLGSSPCYRFKLRKGLNVVKPNASPLTSLNAGEYVYTRGATAGSSNPANMYICGYKKSSGAVTPCDAFVTLDYTSGSMFARNFCLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK48</accession>
    <name>F7KK48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RelA_SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255927.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06151"/>
    <dbReference type="EnsemblBacteria" id="EGN30644">
        <property type="protein sequence ID" value="EGN30644"/>
        <property type="gene ID" value="HMPREF0994_06151"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6738"/>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077095_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="27233" checksum="3E494A0179AEBB45" modified="2011-09-21" version="1">MDELTTKETIWFDGLSGDAFTRILEGERPEEVLESAGPFIELMSRYRCAMMEVETKLRVLDEEFSITYNRNPFETIKARLKKPMSIVDKMRKKKIPLSVENIEKNLNDIAGVRVICSFPDDIYALAAMLVQQDDIRLIAKKDYIANPKPNGYRSLHLIVEVPIFLSNCKRYMRVEVQFRTIAMDFWASLEHKLKYKKDIDNPDDIAKELEECARIISSMDVRMQEIRNRIEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKF6</accession>
    <name>F7KKF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256097.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN47943">
        <property type="protein sequence ID" value="EGN47943"/>
        <property type="gene ID" value="HMPREF0994_06335"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6938"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="468" mass="50842" checksum="192B46D3059C8328" modified="2011-09-21" version="1">MNTKAKRINDFGRDHVPGLVLRVSVPFMFAQFVNVLYSIVDRIYIGNIPVTGADSLAGAGVCAPIITLLSSFATLIGIGGSILFSMRLGQDDKKDAERILGNCFSTLLLFSAVLTVVFLLTKGMLLRWFGASDITYPYADIYLTIYTCGTFFALLSMGMNYFITAQGYPMLGMVTTLIGAVLNIILDPIFIFVFHMDIAGAAAATVLAQLASCLFVLFVLYKKSMPVPLHLRRPELTLVKRILALGFSPFLILATDSIIIIAMNAVLQYHGGPGYGDTLITCATIVQSYMMLITSPMLGITGGSQPLISFNYGANKPDRIRKIILCVLLLCIGFTSFMFLVSRFLPAAFAGIFTDNAEYIALSVWGIRAFTMMIIPLSFQYVFVDSLTALGMTSLSLFLSLFRKTTYFAATCLLPLAFTAASAFYAEPIADGIAALLSSAAFTLVYFKYLRGTGRLVQIGIGKEKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKF7</accession>
    <name>F7KKF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256098.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06336"/>
    <dbReference type="EnsemblBacteria" id="EGN47944">
        <property type="protein sequence ID" value="EGN47944"/>
        <property type="gene ID" value="HMPREF0994_06336"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6939"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080433_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="53"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="278" mass="30910" checksum="BC5205E46D184412" modified="2011-09-21" version="1">MQIGIRLHDTLPMALPERLAHTREQGFSCAHVALSKVIDDFEIKNSTLTPGFAMYLKKLFAQNDLDVAVLGCYLNLADPDGARLAETIEKYKAQIRFASWLGAGVVGTETGNPNSLYVPDPASRTEEALYTFTKNLSCVVEYAEKMGVVVAIEPVCRHIVYDARRARQVLRSIQSPNLQIILDPVNLLDDCDAGRYKDVVKEAIEVLGEDVAVIHVKDFSVSDGKIVSMAAGTGIMDYSDLIRFMKTDKPYIHATLEDTVPENAVQAREFMERLWNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKH3</accession>
    <name>F7KKH3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="9" type="ORF">HMPREF0994_06352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256114.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06352"/>
    <dbReference type="EnsemblBacteria" id="EGN47960">
        <property type="protein sequence ID" value="EGN47960"/>
        <property type="gene ID" value="HMPREF0994_06352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN47960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="13892" checksum="92A367B842539D7B" modified="2011-09-21" version="1">MAKKVAKKVTKKRVRKNVERGQAHIQSSFNNTIVTLTDTEGNALSWASAGGLGFRGSRKSTPYAAQMAAETAAKAAIPHGLKTVDVFVKGPGSGREAAIRALSACGIEVTSIKDVTPVPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKT8</accession>
    <name>F7KKT8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">HMPREF0994_06467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47602.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360102.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06467"/>
    <dbReference type="EnsemblBacteria" id="EGN47602">
        <property type="protein sequence ID" value="EGN47602"/>
        <property type="gene ID" value="HMPREF0994_06467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN47602.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="430" mass="46272" checksum="11BC9764F1CAF9A6" modified="2013-09-18" version="2">MEQYVVEGGNPLVGEVEIGGAKNAALAILAASVMTDETVLIENMPDVRDTNILLQAMQSIGVIVDRVDTHTVKVNASHIHDLVIEDDFIKKIRASYYLLGALLGKYNKAEVALPGGCNIGSRPIDQHIKGFKALGADVRIEHGLIITEAPNLKGSHVYMDVVSVGATINVMMAAAMADGMTIIENAAKEPHVVDLANFLNSMGANIKGAGTDVIRIRGVQKLHKTEYAIIPDQIEAGTFMFAAAATQGDVTVKNVIPKHLESISAKLMEIGCEVEESDDAVRVVASRPLTHTHVKTLPYPGFPTDMQPQITVALGLSQGTSIVTESIFENRFKYVDELTRMGASIKVEGNTAIIDGVARYTGASITAPDLRAGAALVIAALAAEGVSTVDDIRYIERGYENFPEKLRGLGAQIEKVDNERDIKKFRFKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKU3</accession>
    <name>F7KKU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256234.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06472"/>
    <dbReference type="EnsemblBacteria" id="EGN47607">
        <property type="protein sequence ID" value="EGN47607"/>
        <property type="gene ID" value="HMPREF0994_06472"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7087"/>
    <dbReference type="eggNOG" id="ENOG5032S4Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172580_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN47607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="88" mass="10601" checksum="93C349A2565FC59F" modified="2011-09-21" version="1">MFRLWAKIFKDNRMLKDTVICDDSDDTRTHKVFHALDEICYQFDLGKPIWLDVTVLDFKKHSKARFTPDNFVEQIDFDFLEIQVIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL71</accession>
    <name>F7KL71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bro-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862442.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06604"/>
    <dbReference type="EnsemblBacteria" id="EGN47323">
        <property type="protein sequence ID" value="EGN47323"/>
        <property type="gene ID" value="HMPREF0994_06604"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7227"/>
    <dbReference type="eggNOG" id="COG3617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046670_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005039">
        <property type="entry name" value="Ant_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03374">
        <property type="entry name" value="ANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02498">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01040">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51750">
        <property type="entry name" value="BRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="255" mass="28848" checksum="146A81030E8CF60C" modified="2011-09-21" version="1">MNQIEIFNSPEFGSIRTLEQNGKVLFCGTDVATALGYTNPRKAVRDHTRGGTKCSIGVQTGKKADGSPAVQMVEMLFIPEGDLYRLIAHSKLPSAERFEQWVFDEVLPVIRKHGAYLTKEKLWEIATSPEALIKLCSELLAEREENASLREENALLESKAAFYDLFIDLNHSTNLRTTAKELLVPERRFVRFLLEKRFVYRTASGNVLPYAKPANEGLFCVKDYCNHGHIGSYTLITPQGKLYFAQLRDMILMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLB1</accession>
    <name>F7KLB1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fn3_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256393.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06640"/>
    <dbReference type="EnsemblBacteria" id="EGN46564">
        <property type="protein sequence ID" value="EGN46564"/>
        <property type="gene ID" value="HMPREF0994_06640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7261"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="672"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN46564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="752" mass="83183" checksum="3B3E6CE98EAD51C8" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLI3</accession>
    <name>F7KLI3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256474.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06721"/>
    <dbReference type="EnsemblBacteria" id="EGN46645">
        <property type="protein sequence ID" value="EGN46645"/>
        <property type="gene ID" value="HMPREF0994_06721"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7350"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890555_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357028" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="114"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="29952" checksum="BB06BBA08685B054" modified="2011-09-21" version="1">MKKGVKFTALALAASLMFTYPLCNGITADAAAPLKTVESSNVPTKYTGMSLSILGDSLSTFNDYIPRDYNIFYPGNSGIPMVEGTWWYQVLNATGMRLCSNASSANTNVTGNSLATDGSAPGCSFRRIMDLKGADGTSPNVIVIYMGVNDFARDIPLGSFKAPSLQTEGTPATFSSAYELMLLKIKTLYPDAAVYCCTLFARDPGLRAPGTNTPVNRNGDSIMDFNKQIRAIAAAYGASVIDVYNCGITYDNLSVFTSDGVHPNLPGAQLFANCVTAALVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRW4</accession>
    <name>S2KRW4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TraG-D_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07175"/>
    <dbReference type="EnsemblBacteria" id="EPC05179">
        <property type="protein sequence ID" value="EPC05179"/>
        <property type="gene ID" value="HMPREF0994_07175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015347_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TraG-D_C" evidence="1">
        <location>
            <begin position="131"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="316" mass="35356" checksum="C521376DB2EB6957" modified="2013-09-18" version="1">MGRGKRPRRKSEPYLSVSVDLMFDALEAEKPNHFAVRQYKKYKLAAGKTAKSILISCGARLAVFDIAELREVTSYDELELDTLGDRKTALFLIMSDTDDSFNFLISMCYTQLFNLLCEKADDVYGGRLPVHVRCLIDECANIGQIPKLEKLVATIRSREISACLVLQAQSQLKAIYKDNADTIIGNMDTSIFLGGKEPTTLKELAAVLGKETIDTYNTGESRGRETSHSLNYQKLGKELMSQDELAVMDGGKCILQLRGVRPFLSDKYDITKHPNFKYTADASDKNAFDIEAFLSTRLKLKPNEVCDVYEVDTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS88</accession>
    <name>S2KS88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent helicase Lhr and Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359750.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06982"/>
    <dbReference type="EnsemblBacteria" id="EPC05314">
        <property type="protein sequence ID" value="EPC05314"/>
        <property type="gene ID" value="HMPREF0994_06982"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="31"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="250"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1392" mass="155921" checksum="437ABB174A4015D6" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSS5</accession>
    <name>S2KSS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359730.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06970"/>
    <dbReference type="EnsemblBacteria" id="EPC05302">
        <property type="protein sequence ID" value="EPC05302"/>
        <property type="gene ID" value="HMPREF0994_06970"/>
    </dbReference>
    <dbReference type="GeneID" id="29723734"/>
    <dbReference type="eggNOG" id="ENOG50337YC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1784368_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="137" mass="15904" checksum="2A2769263943C509" modified="2013-09-18" version="1">MADQDFKYIIQDLTNIYLGARSTYEELMEDENVPHKLKEIIVRVMLTEVAPDTTPENHVFYMEKESASFKAYKKMKARFKMSVWETADGKKRKKSGYVNREYSVEEIVGSRELHEKKDTIIVEEVHISKLGLGAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWK1</accession>
    <name>S2KWK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07053"/>
    <dbReference type="EnsemblBacteria" id="EPC05385">
        <property type="protein sequence ID" value="EPC05385"/>
        <property type="gene ID" value="HMPREF0994_07053"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QUF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_229798_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004510279" evidence="2">
        <location>
            <begin position="43"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="2205" mass="237280" checksum="2302D7720616D23F" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2G1</accession>
    <name>F7K2G1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3849 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249989.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00040"/>
    <dbReference type="EnsemblBacteria" id="EGN48273">
        <property type="protein sequence ID" value="EGN48273"/>
        <property type="gene ID" value="HMPREF0994_00040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.43"/>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098267_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024383">
        <property type="entry name" value="DUF3849"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12960">
        <property type="entry name" value="DUF3849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3849" evidence="2">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="169" mass="19640" checksum="C6CB831F9C4B1708" modified="2011-09-21" version="1">MKDTTQLYIYPASYVREHGELEQYRASYKANIACKEAIEQAIADHYRDNRLGTEAVHQVLEQFGYDRMFYVLAGTVRQKDWDGRISRDNKAWAKTIPVYENPDGFGQDRNVYFVVDRSHPGLVDLFLTQARLDYTKEHGKKVSIREGIKQSTERTAAVHAPTKRKEPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2H8</accession>
    <name>F7K2H8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250006.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00057"/>
    <dbReference type="EnsemblBacteria" id="EGN48290">
        <property type="protein sequence ID" value="EGN48290"/>
        <property type="gene ID" value="HMPREF0994_00057"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.61"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="68"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="172"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN48290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="381" mass="44533" checksum="5F479E82FB1CA260" modified="2011-09-21" version="1">MARKGENIYKRKDGRWEGRYRMNNPADGRKRYCSVYGKTYKEVKEKLFIRKREHILDKGGCGCLPDGITMGEAVRMWLEERRYRWKESTFSTYRSIIEKHILPVIGKWMVETWNTTSYREYFKILRKRKEGKELSENYLHQIQIILSQILRFLDGKYHCGGLEQPHTYAAVKQRPVHTPLGTDIRKLEEYLQNEAAKGDVTCLGILLTGCSGIRIGELCALKWEDIHFDTGTMHIGKTLQRIRTFQDNGEETGGSHATGTKITITSPKSSHSDREIPIPDFLLELLQRKRNQKGYLISGKKKEYTEPRTLQYRFQRILKTLGIPYFNFHMLRHPYVKPTTKKFASFLKFFRAAAIAARSCSIRYSWLMLPFQISPFLKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2L2</accession>
    <name>F7K2L2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:58695"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.144"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase PfkB family. LacC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250040.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00091"/>
    <dbReference type="EnsemblBacteria" id="EGN42708">
        <property type="protein sequence ID" value="EGN42708"/>
        <property type="gene ID" value="HMPREF0994_00091"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.96"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050013_0_2_9"/>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005988">
        <property type="term" value="P:lactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0423">Lactose metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="33128" checksum="FE05B007BEF0859C" modified="2011-09-21" version="1">MILTVTLNPAVDKTYRTGELFPGRVNRMRSVDNIPGGKGINVSKILRQYDYEVTATGFLGGYQGRWMEDQLDRLKIRSAFVQVDGETRTSMNIVADNGYVTEILEPGPHISDTQLKEFMQKFASLAEESGLVILSGSAAPGIPTDIYARLILSASSMGKQVILDTSGELLKEGVKAAPSVVKPNRKELEYIIGRRLQDMNDIKDASSVLLSDGVGLVIVSLGDKGLLLAGKGRCLYARVPRVTALNTVGCGDSVVASLAMSMTSGADIEEMLRKAAAVSAANATTLESGNVPLKLAEEILRDIHIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Q7</accession>
    <name>F7K2Q7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250085.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00136"/>
    <dbReference type="EnsemblBacteria" id="EGN42753">
        <property type="protein sequence ID" value="EGN42753"/>
        <property type="gene ID" value="HMPREF0994_00136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="33823" checksum="25C27E70F3E800D4" modified="2011-09-21" version="1">MKIKPSKSRIAFQIFNYTLMLLATFVCVYPFWYIVIYTFSDAAKAGINNPIFLPRGFSVSNYVDIFKLSGFFPALGISVLRTVVGTVAAVLVCSFLGYMFTKEEMPGRKFMYRFLVMTMYINGGLISTFIVMKSYGLLNTFWIYILPMMISAYNIVLIKTYMESLPASLEESAMLDGAGYIKVFTSIILPLSKPIIATVAVFVAVGHWNSWFDNHIYTRGESSLTTLQYLLYNYLNESQRLAEQIKNTSNLSSIENAMGTISPKGVRMTITVLASLPIFMVYPFMQKYFVKGIMIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2U5</accession>
    <name>F7K2U5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250123.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00174"/>
    <dbReference type="EnsemblBacteria" id="EGN40731">
        <property type="protein sequence ID" value="EGN40731"/>
        <property type="gene ID" value="HMPREF0994_00174"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.184"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="276" mass="32223" checksum="EC4457632B6ABB64" modified="2011-09-21" version="1">MTERKSKMLPLSELTLLDRFLFDAAMEDKDFHKSVLQIILGKEITFLTKNETEKELRVSPLLRSIRMDVYAMDEDGIIYNSEMQKQLKYDLPKRSRYYQGMLDSSLLEPGSIRFSLLNDSYIIIITPYDVFGLGKYRYTFRARCDEELSCILPDGAVRIFLNTRGKNREEVGDELAWFLEYAEKTDEETVRKSGSEVLRRIHEHICKLKASEEMGVRYMQAWEEKVKEREDGREEGLKEGIFRTKRVLKLAAEGKKKEEIAEMCGITVDEVAEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V5</accession>
    <name>F7K2V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250133.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00184"/>
    <dbReference type="EnsemblBacteria" id="EGN40741">
        <property type="protein sequence ID" value="EGN40741"/>
        <property type="gene ID" value="HMPREF0994_00184"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.196"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="224" mass="24292" checksum="BBC93B1F9E50068E" modified="2011-09-21" version="1">MSVLETRNVFYSYTKGNIILSGINAVFETGKLHVIIGPSGSGKTTLLSLLGGLDSPAKGKILFDGEDIAERGLEYHRRQHVSLIFQSYNLIDYLTPVENVKLTARQDALPVLKRLGLSAEEAGRSVLKLSGGQQQRVAIARTLASGAPFILADEPTGNLDEDTAAEITGILMESAHELDRCVIVVTHSRELAKRADIVWKLKGGSLQRVSPCLRADVPGQEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2W7</accession>
    <name>F7K2W7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250145.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00196"/>
    <dbReference type="EnsemblBacteria" id="EGN39229">
        <property type="protein sequence ID" value="EGN39229"/>
        <property type="gene ID" value="HMPREF0994_00196"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="413"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN39229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="513" mass="59562" checksum="1FC69BC5737AEE33" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7K359</accession>
    <name>F7K359_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_00288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250237.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00288"/>
    <dbReference type="EnsemblBacteria" id="EGN33429">
        <property type="protein sequence ID" value="EGN33429"/>
        <property type="gene ID" value="HMPREF0994_00288"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.311"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="227" mass="25892" checksum="2A5A97D0C94D8B75" modified="2011-09-21" version="1">MKRIAVVEDEAYMREEIAEMLRNAGFEVDEIISFEDTAGQLLRLSPDLILLDINLPQASGFQICREIKQKSAIPVLVLTSRDQMRDELHALELGADEYLTKPCRKERLLARTANVLKRYEGRSHMLEGPGFLLDRQTYALYIHNRSVVLPGNQGRLLEVFLTHGGNPVKKEELLTALWGTTEYIDENALQVNLTRLKKTMQELEMCLKIIPVRGVGYQLIPEGNKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3A0</accession>
    <name>F7K3A0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide/nickel transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00333"/>
    <dbReference type="EnsemblBacteria" id="EGN33474">
        <property type="protein sequence ID" value="EGN33474"/>
        <property type="gene ID" value="HMPREF0994_00333"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.357"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356599" evidence="6">
        <location>
            <begin position="43"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="104"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN33474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="332" mass="36025" checksum="1F99ED968DB32D96" modified="2011-09-21" version="1">MKHNLLIRKTGRKFIRMLLLLITVSIVTFTLVSMSPIDPLQANVGQAALGAMSQEQKAKLEEYWGVNVPPVRRYLNWAGGFVRGDMGISLLYRQPVSQVIGVKLSNSLFLMVFAWLISGILGLVLGILAGVFRGTWADRIIKGYSLLISSTPVFWLALLLLLVFAVWLKVLPIGLSVPIGVESAGVTFLDRLRHAILPAVTLSITGVAGVTLHTREKMIDVMESDYMLFARARGESTWSMVKKHGLRNILLPAMTLQFASVSEIIGGSVLVEQVFSYPGLGQAAVTAGTGSDVPLLLGITIVTAAIVFFGNFIADILYGVIDPRMRKGGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3B1</accession>
    <name>F7K3B1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33485.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00344"/>
    <dbReference type="EnsemblBacteria" id="EGN33485">
        <property type="protein sequence ID" value="EGN33485"/>
        <property type="gene ID" value="HMPREF0994_00344"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="8"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN33485.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="411" mass="44289" checksum="DA65F83CB3D4014D" modified="2013-09-18" version="2">MKKGFSKDFYLVLIGQIISLFGNAVIRFALPLHLLSVTHSPSLLGIVSGFAFLPLAVMSPVGGLIADRVNKRNIMVVLDFFTAGLVLAFLLLSGRVSLVGLILVMLFLLYGISGAYQPSVQASIPLLVTEEAIMPANALINMISSLSGLLGPALGGIAYGLWGITPILYLCAGCFFLSALMELFIHIPFTRKELTCSLFRELAGDIKESLLFITREKKEIGKLTLCCTAVNFFLSALMIISLPVIVMQILSFPKGNASEMYGFLQALMAAGGLAGGMAAGIFSKKLNIRNSWKLLFTSSLLLIPMGAALQPAIPAYAAYTIIALSGLLIMALASLYTIQIMSYIQLTTPAALIGKVISWIIALSSCAQPAGQIMYGFLLEHLQTKIWLIFTLTALLSMLVSYWNKQAAKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3H1</accession>
    <name>F7K3H1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00268 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250276.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00327"/>
    <dbReference type="EnsemblBacteria" id="EGN33468">
        <property type="protein sequence ID" value="EGN33468"/>
        <property type="gene ID" value="HMPREF0994_00327"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.351"/>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="273" mass="29770" checksum="9E9FC04C4D3EF79F" modified="2011-09-21" version="1">MEPTGKKKEELCALMDKLAAEDIMVAFSGGVDSSLLLKAACDSTGKTGKKVYAATVQTQLHPSGDMEVAKRVAGEMGASHIVLEIDELAEAGIGNNPTDRCYRCKKFLFQKMKQEAQKLGVPVIVEGTNEDDLHVYRPGIRAIRELGIASPLAELGITKAQVREIAADYGISVSERPSAPCLATRFPYGTQLDMAEMEKVDEGESYLKSLGLYNVRIRVHGEVARIEVDKKDMAAVMEHRMEIVTALENLGFVYVTLDLKGFRSGSMDVGLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3N5</accession>
    <name>F7K3N5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250413.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00464"/>
    <dbReference type="EnsemblBacteria" id="EGN48182">
        <property type="protein sequence ID" value="EGN48182"/>
        <property type="gene ID" value="HMPREF0994_00464"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.511"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN48182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="229" mass="25508" checksum="53DDA187F94B2410" modified="2011-09-21" version="1">MEFLKIKELCKVYGKGENQVTALDHISLTIEKGEFTAIIGSSGSGKSTLLHAIAGVDIPTSGKIYLEGQDVYGQSNEKLAIFRRRQVGLIYQFHNLIPTLNVEENITLPILMDKRKVNQKRLNDLLELLGLEERKTHLPNQLSGGQQQRVAIGRALMNAPAVMLADEPTGSLDSKNGQEIIHLLKESHNKYHQTLIIVTHDENIALQADRIICIADGKVVRDERQVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3W5</accession>
    <name>F7K3W5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250493.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00544"/>
    <dbReference type="EnsemblBacteria" id="EGN44732">
        <property type="protein sequence ID" value="EGN44732"/>
        <property type="gene ID" value="HMPREF0994_00544"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.592"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011142_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="418"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN44732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="504" mass="52473" checksum="15BA8EF861B58DC1" modified="2011-09-21" version="1">MRIQHNIMALNSHRQLGNNNSAVSKSLEKLSSGYRINRAGDDAAGLAISEKMRAQIKGLTAASDNSQDAISLVQTAEGGLQEVHSMLNRMQELATKSSNGTYTDDVDRKALQDEVSALKDEINRIADSTNFNGINLLDGSMGVGTTGATDTLAQGAAAGQLKTNAVNVSFAAPEGYKLKIASGADKAAATATFDEATKTITLTLESTAGKVTTQKDIDKLLQGVALPSEAMGKVKVTIDNDIEFATPGAAANIKTLTSVAAKQATATDTNTGITVSSTKAGVNTHKLTINNTTTEATGAKALVSGDATLALEAGKSYTSSDINKMLADAGVEMRMDFDGSKTGAEIYAGKSAAADHTFTLGDTVAGAGLSAGGGIELQIGDTNDAWNQLELSIDDMHVSSLGIGDIDISTRPGASAAISKIKDAINQVSTSRGKLGAIQNRLEHTINNLGVTTENITAAESRIRDVDMAKEMMEFTKNSVLMQSAQAMLAQANQQPQSILQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K434</accession>
    <name>F7K434_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250574.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00625"/>
    <dbReference type="EnsemblBacteria" id="EGN44813">
        <property type="protein sequence ID" value="EGN44813"/>
        <property type="gene ID" value="HMPREF0994_00625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.678"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010661_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="2">
        <location>
            <begin position="16"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="643" mass="69750" checksum="B87811D8FCDE45D4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K585</accession>
    <name>F7K585_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00934"/>
    <dbReference type="EnsemblBacteria" id="EGN43243">
        <property type="protein sequence ID" value="EGN43243"/>
        <property type="gene ID" value="HMPREF0994_00934"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1020"/>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048266_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="15645" checksum="3A34E8D5883BAC21" modified="2011-09-21" version="1">MADSKKDKLNNSESEIIIYQTEDGHTKIDVKFVDETVWLTQAQLCELYHTSKSNISEHIKHIFEEGELDEVSVVRKFRTTAADGKNYNTTYYNLDMIISLGYRVKSLIVNLLHFLKWYKINCIMQHMGIRLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K595</accession>
    <name>F7K595_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01024"/>
    <dbReference type="EnsemblBacteria" id="EGN42997">
        <property type="protein sequence ID" value="EGN42997"/>
        <property type="gene ID" value="HMPREF0994_01024"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1120"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035883_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="56"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="424" mass="49209" checksum="3CE1361E27257FCA" modified="2011-09-21" version="1">MLNNKKKDMTPFDMNKKPVKQYPFLLPLIWGGAWLMTRSLGLKIEKAGMEKMKPPYLVLSTHQGFSDYYIAPLALFPHRANYVSDMEGFAAFGEWLYRGIGCIGKRRYVSDIAVVKNIYTALHKNRQIVAVFPESRHSNAGTTAYIPQNMGKLAKLMKVPVVMLSVHGSYLAGPFWDEAHTRKVPLRAKLECIYTKEELAQAQEDDVQQKIEEHLRYDEYKWQWEEKIAITYPRRAEGLHMALYQCRSCGEAFYMKSKGSSLFCEACGSGWEMDEYGRLVGEKKKITAIPDWYEWQRGEVEKEIRNGTYRCEFAVRVEALPNAKGFIPMGEGRLVQEESGFTLFVQNRELFFDHRSRESVQTEYNYRDRGPCIVLSDKDCCYYIYSDDPGFGPTKIQFAGEYYYRMRKQGEVPFDFGKHLSENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5B7</accession>
    <name>F7K5B7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250995.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01046"/>
    <dbReference type="EnsemblBacteria" id="EGN43019">
        <property type="protein sequence ID" value="EGN43019"/>
        <property type="gene ID" value="HMPREF0994_01046"/>
    </dbReference>
    <dbReference type="GeneID" id="29724684"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1144"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="369" mass="40039" checksum="2D57F7BF835F39A5" modified="2011-09-21" version="1">MKQGTEMKINRLPVRTWNWLHMNESSLSDIDTVLLSRDKPADGPVLTLPKEGVSCIRGMSTGMVEAGFRDIATGMGPDMEELIRESGTPVEIIRVKKGEKPEAPVKLAFPCKEGEHGLYAAYVYAEEGSSVTVIMEADSARQAGGTAGFQTRLYAEKDARIRLIQVQLLGKEYGYLNDVGGSCEEGASIELVQLFLGARNIYAGGSVNLAGDGSRMQTAIGYLGTKNQKLDMNYTAEHYGKKTESLIEAKGVLRDNASKLFRGTIDFQKGCAGAEGAEKEEVLLLGDEVVNRTIPLILCGEEKVQGSHGATAGRMDEEKLFYFCSRGLSREEACDMMARAGIDAVCSKIPDEALVEKIQAYLEEGGRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5K2</accession>
    <name>F7K5K2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251080.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01131"/>
    <dbReference type="EnsemblBacteria" id="EGN42893">
        <property type="protein sequence ID" value="EGN42893"/>
        <property type="gene ID" value="HMPREF0994_01131"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1241"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="43"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="28872" checksum="D31CF460F5D34203" modified="2011-09-21" version="1">MKTDSSTECWGNVGCEWIQKSQTNDFRMYYIMPYTMEKLGDVKGLSILDLGCGEGGYSRELARKGAKVTSVDCSEMAVSYAVSKAKEDGLEISHLIRNSNDLYGITDNTFDIVLCAMMLMDIEDFDGAMKEINRVLKSHGKVFISILHPCFKPPVEHKWVKEKECMQVVVKDYFHPAEWTGKIDGIKESVIYRHRTLSDYVKVFARNGFIITDMNEPIPTEEQAAMSPRIAWLSKIPMYLFIELKKTASFSGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5V0</accession>
    <name>F7K5V0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251178.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01229"/>
    <dbReference type="EnsemblBacteria" id="EGN42476">
        <property type="protein sequence ID" value="EGN42476"/>
        <property type="gene ID" value="HMPREF0994_01229"/>
    </dbReference>
    <dbReference type="GeneID" id="29726913"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1342"/>
    <dbReference type="eggNOG" id="ENOG502Z7KA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035900_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046107">
        <property type="entry name" value="DUF6044"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19510">
        <property type="entry name" value="DUF6044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="602" mass="69798" checksum="EEA757728B4A1C0A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6D0</accession>
    <name>F7K6D0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysacc_synt_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01435"/>
    <dbReference type="EnsemblBacteria" id="EGN41909">
        <property type="protein sequence ID" value="EGN41909"/>
        <property type="gene ID" value="HMPREF0994_01435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1563"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="301"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="629" mass="71328" checksum="F600E9576575915B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6D1</accession>
    <name>F7K6D1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251385.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01436"/>
    <dbReference type="EnsemblBacteria" id="EGN41910">
        <property type="protein sequence ID" value="EGN41910"/>
        <property type="gene ID" value="HMPREF0994_01436"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1564"/>
    <dbReference type="eggNOG" id="ENOG502Z9GS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328407_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="846"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="873" mass="98624" checksum="57A792C60E587F00" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6E4</accession>
    <name>F7K6E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudaminic acid biosynthesis-associated protein PseG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01449"/>
    <dbReference type="EnsemblBacteria" id="EGN41923">
        <property type="protein sequence ID" value="EGN41923"/>
        <property type="gene ID" value="HMPREF0994_01449"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1579"/>
    <dbReference type="eggNOG" id="COG3980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023406_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020023">
        <property type="entry name" value="PseG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03590">
        <property type="entry name" value="PseG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="3">
        <location>
            <begin position="203"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR620023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR620023-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="349" mass="38682" checksum="7F5EF53B279DB49F" modified="2011-09-21" version="1">MNTEKSILIRTDGNQDIAAGHLMRCLSIAQALHEKKVPVFFAAADETSAGLLRTFFGPGEDYPIFILHSDYRKPDSETDSLISLISQFHIGCLLVDSYFVTPSYLETLSEVIKTAYIDDLYSFDYPVDLLINYDAVIPENFYQQARRRLLGLSYTPLRKQFSRLQPTVRPEVKEILISTGGTDPCHAAESLLSQLIDSEESRDWCFHVLAGPMHSDRKSLEQMALSHPGLRLYEHVAQMAELMQRCDLAVSAAGTTLFELCAAGTPAISFTMADNQFTTAVQMEAGAGIPCAGDVRTAKDFTSGLCRILYGLASDYEKRKALSSSMHRLIDGNGAGRIADELIRLLYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6J9</accession>
    <name>F7K6J9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251458.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01509"/>
    <dbReference type="EnsemblBacteria" id="EGN41983">
        <property type="protein sequence ID" value="EGN41983"/>
        <property type="gene ID" value="HMPREF0994_01509"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="109" mass="12417" checksum="380404E6A926AFD1" modified="2011-09-21" version="1">MDKKLVLRRFADDVINLLGTSLVKIILYGSYARGDFHENSDMDVMILTSLDDDGIRKIENSVYDIASDYELSENVHISVSIKNIDHFNYWLGALPYYDNVEKEGIVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6R0</accession>
    <name>F7K6R0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251521.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01572"/>
    <dbReference type="EnsemblBacteria" id="EGN42046">
        <property type="protein sequence ID" value="EGN42046"/>
        <property type="gene ID" value="HMPREF0994_01572"/>
    </dbReference>
    <dbReference type="GeneID" id="29726660"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1718"/>
    <dbReference type="eggNOG" id="ENOG5033AM7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2421815_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="94" mass="11012" checksum="49C5604C93AC97AD" modified="2011-09-21" version="1">MFGKKKEKEKEKVIRVCLKGEEVYRGTMTDLPLKEEIILSKSDEFFNDPNPCFIHRSAVRVRLIAELEEAGAQENWELWNCYADLPGVDFIEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6T8</accession>
    <name>F7K6T8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01605"/>
    <dbReference type="EnsemblBacteria" id="EGN42079">
        <property type="protein sequence ID" value="EGN42079"/>
        <property type="gene ID" value="HMPREF0994_01605"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503131Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2553915_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="82" mass="9138" checksum="AF9EF2465630053A" modified="2011-09-21" version="1">MEIISEILDLIVEGTLELIGSKKVPMILRIIAGFVLIGLCSGLVGLFVYLGMMHQHPLLIVIGVVLLLFMAVTVYRYIKQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6W7</accession>
    <name>F7K6W7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01634"/>
    <dbReference type="EnsemblBacteria" id="EGN42108">
        <property type="protein sequence ID" value="EGN42108"/>
        <property type="gene ID" value="HMPREF0994_01634"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1785"/>
    <dbReference type="eggNOG" id="ENOG50333ZN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204509_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024272">
        <property type="entry name" value="MAFF-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12750">
        <property type="entry name" value="Maff2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="52" mass="5420" checksum="D34E296E7E37FE54" modified="2011-09-21" version="1">MEFFNSAVDTLQTIVVGLGGALCVWGGVNLLEGYGADNPASKSQGIKQFMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Z6</accession>
    <name>F7K6Z6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen regulatory protein P-II 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251520.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01571"/>
    <dbReference type="EnsemblBacteria" id="EGN42045">
        <property type="protein sequence ID" value="EGN42045"/>
        <property type="gene ID" value="HMPREF0994_01571"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1717"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="112" mass="12583" checksum="EA2F9B01FA7C6E4E" modified="2011-09-21" version="1">MKKLEIIIKPEKLEDLKEVLDTEEVNGLNIVNIMGYGNQKGIVKKYRGAEYRVNLLPKIKVETVVAKENADKLIDKIVKEINTGNIGDGKIFVYDVADAVRIRTGERGKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K749</accession>
    <name>F7K749_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 14">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HMPREF0994_01678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12 14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 14"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251591.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01678"/>
    <dbReference type="EnsemblBacteria" id="EGN41716">
        <property type="protein sequence ID" value="EGN41716"/>
        <property type="gene ID" value="HMPREF0994_01678"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1832"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 12 14" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="5"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="15">
        <location>
            <begin position="354"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGN41716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="471" mass="50211" checksum="B6512FB2D8F8D6B6" modified="2011-09-21" version="1">MEMQYDLIVIGAGPGGYPAAIRAAQDGKKVAVVEKGRLGGTCLNNGCIPVKTLLHSSGLYRKMREASGEGIRVTDVQLDGAALHKRQEEVIQTLQEGIALQFKKNKIALYQGKAVITEENCVMVTSEADGQTSRLTARHILIAAGSEPAMLPIPGISSPGVENSTSILSGERLYDHLIIIGGGVIGMEFAQFYSDLGKKVTVLEAMDRILPGMDKEISQNLKMILKKRGVDVHTKAAVTRVEKMEQGGWLCYYKEGTDPEKTEQESWISADGLLVAVGRRACGEGVFSPEMAIRAGVEKGIIPADENYQTRIPGIYAAGDVTGGIQLAHAATAQGLLALDHMEGRCPSRNLQVIPSCVYTDPEIACAGITADEAKAAGILVKTGKYIMSLNGKSVLSGQERGFIKLVAEEGTGRLLGAQLMCARATDMIGVPALAIATHRTVQELAATVLPHPTFGEGIGEAAQELCRRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7H8</accession>
    <name>F7K7H8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01807"/>
    <dbReference type="EnsemblBacteria" id="EGN41620">
        <property type="protein sequence ID" value="EGN41620"/>
        <property type="gene ID" value="HMPREF0994_01807"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1973"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="49"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="31679" checksum="E0A239CDCCE0DC1D" modified="2011-09-21" version="1">MPREYERLPEKDMDKILHTRQKPYYETETEQLYLGDSFVLLPKMEPESVDMIFADPPYFLSNDGVTCQGGKMVSVNKGDWDQGMDCNSKHAFNRKWLRLCKKVLKPDGSIWISGTLHNIYSIGLALEQEGYKIINNITWQKTNPPPNLACRCFTHSTETILWARKDNKKAHHHFNYDLMKEENGGKQMKDVWTGSLTRASEKKEGKHPTQKPEYLLERIIRASTEDGMLVLDPFCGSGTTGVAARKLGRKFIGLEMQEDYIKISRRRLEKTNTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Q6</accession>
    <name>F7K7Q6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251864.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41356">
        <property type="protein sequence ID" value="EGN41356"/>
        <property type="gene ID" value="HMPREF0994_01951"/>
    </dbReference>
    <dbReference type="GeneID" id="29727171"/>
    <dbReference type="eggNOG" id="ENOG50338QW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1319470_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356702" evidence="1">
        <location>
            <begin position="27"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="207" mass="23025" checksum="1AFD95C287C44B1B" modified="2011-09-21" version="1">MKKKRTIIFLCIILLLAAAFCLTAFRVRGSVSVKGDGSTPSPDPVFFSQKDPLWAGDLLGDSSFTMETSGCLTACLAAELRMQDISIPEINAMDPGTLNSFFSGKQVYDKEGNIQWDPLSSALNVSLERINGISAMRKTDLTALLSEGIYPIVRVRVKGLGNFHYVLLVKCQDGQFWCMDPLHLEEELVPLSDFGNRIYAIRYLYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7T2</accession>
    <name>F7K7T2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251890.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01977"/>
    <dbReference type="EnsemblBacteria" id="EGN41382">
        <property type="protein sequence ID" value="EGN41382"/>
        <property type="gene ID" value="HMPREF0994_01977"/>
    </dbReference>
    <dbReference type="GeneID" id="29727340"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2173"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363784" evidence="1">
        <location>
            <begin position="39"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="609" mass="69764" checksum="CDBDF9849E3AE813" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7W4</accession>
    <name>F7K7W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dCMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251923.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02010"/>
    <dbReference type="EnsemblBacteria" id="EGN41415">
        <property type="protein sequence ID" value="EGN41415"/>
        <property type="gene ID" value="HMPREF0994_02010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2205"/>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="159" mass="17740" checksum="73ABA86F480CB0E6" modified="2011-09-21" version="1">MKRTDYITWDEYFMGVAKLSGMRSKDPSTQVGACIVSQDNKILSMGYNGFPIGCSDDEFPWDKKGEEEDTKYPYVTHSELNAILNYRGGSLAGAKLYVSLFPCNECAKAIIQSGIKEVIYECDKYADTPAVRASKRMLDAAGVVYRQYESAGRNVTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K800</accession>
    <name>F7K800_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251960.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02047"/>
    <dbReference type="EnsemblBacteria" id="EGN41452">
        <property type="protein sequence ID" value="EGN41452"/>
        <property type="gene ID" value="HMPREF0994_02047"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2246"/>
    <dbReference type="eggNOG" id="COG4481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180138_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009296">
        <property type="entry name" value="DUF951"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06107">
        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037263">
        <property type="entry name" value="DUF951_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="60" mass="6973" checksum="87A28F2642B4D551" modified="2011-09-21" version="1">MDIQVGNIVKLKKQHPCGSREWEVLRIGADFRLKCMGCGHQIMVPRKLVEKNVREIREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K860</accession>
    <name>F7K860_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41514">
        <property type="protein sequence ID" value="EGN41514"/>
        <property type="gene ID" value="HMPREF0994_02109"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2423180_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="91" mass="11381" checksum="AF5F64B9A74F2BC9" modified="2011-09-21" version="1">MPLGLRHSFYVMYSQKIMQQKRILYMNQYYLLKNGDEHLNSWIYMSNKMYQILLFIIKENASAKYKERQKFTLLNEIENYRRLSWRLLYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8H3</accession>
    <name>F7K8H3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252067.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02154"/>
    <dbReference type="EnsemblBacteria" id="EGN41061">
        <property type="protein sequence ID" value="EGN41061"/>
        <property type="gene ID" value="HMPREF0994_02154"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2357"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="398"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="503" mass="57840" checksum="9E27B07DFB8DAB52" modified="2011-09-21" version="1">MHSPNILLITSDQQHYNTLGICNPEIHTPNLDRLAREGTLFNRAYCSNPTCTPSRASIITGLYPSQHGAWSLGTKLPEQVPALGDYLQKAGYRTALIGKAHFQPKASTDSFSSLEAEPLLYDSSFWKGFHGPFYGFEHVELMRNHTCEYLVGQHYALWLEEQCPGKWREYFSPPAGTLPANSLYQWEIPEEYHYNTWITRRCCDLLGSFRRENRPFFLWASFPDPHPPYLAPSPWCDMYTGAPLTVPEGSPGEFMNFPPHFAMTQQEDADWSSYRESGQFLHGLRFHAGIAPEQIRRNMEVYYGMISYLDYCTGILLDRLDTLGLCEDTLVIFTTDHGHLFGQHGLHYKGPFLYEDLIRVPLLIRFPPEVPAGRTCGSLQSLVDLAPTLLDFCSLPVPPSMSGVNQRQVWMGNEEAARRYVLCENHQEPSSLQQRCYVDERYKLTVYADRDWGELYDLAEDPGESHNLWVHPDYRDLKEKLLLHALWQEMDREPMWMPRIAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K918</accession>
    <name>F7K918_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00288 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252248.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02347"/>
    <dbReference type="EnsemblBacteria" id="EGN40989">
        <property type="protein sequence ID" value="EGN40989"/>
        <property type="gene ID" value="HMPREF0994_02347"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2567"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034061_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="182"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="259"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="331" mass="37687" checksum="E7FF1E3D7DE0C312" modified="2011-09-21" version="1">MEREEEEKKHFAVLIDADNISEKYASSIFNEIADYGYASYRRIYGNWAKGNGWKEDTLLENSINPIQQFNYTIGKNATDMAMVIDAMDILYSGKVDGFCLVTSDSDFTKLAMRLREEQKYVIGMGESKTPLALTKACNKFIHLDLISGEVEDKSTESVKVTGTGRRQKTSTVEEKQDSTVTPISEIEESIITFVQNNENKGKPTYLGEVGSRLCDKFIEFDARNYGYTKLVTLLKDKCPKLVIKQEGTSYQIELKEQTEPENLEKEIIAFLKRNGGKVDNLSLVLEQLKKKHPNFNLNDYGYSRISSFLRSFDKITVHGNALMLKETVHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9T0</accession>
    <name>F7K9T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252514.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02613"/>
    <dbReference type="EnsemblBacteria" id="EGN40596">
        <property type="protein sequence ID" value="EGN40596"/>
        <property type="gene ID" value="HMPREF0994_02613"/>
    </dbReference>
    <dbReference type="GeneID" id="29723542"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2864"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045643_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="464" mass="52318" checksum="2171E6AAD3CA2571" modified="2011-09-21" version="1">MKNRNKQLRVGLVPTRREAFANETTTKQKKAIVERFRWLAAELDFEMVDIEDINEEGMLMTYRDVEAAYDKLTAAKVDALIFPHCNFGQEEAVGRLAKDMNLPVLIWGPRDGYPNGLEWRPTDSQCGMFATTKLLMHYGVTFSYIENCELESDILREELADFLAAANVVKAFRALRIARISSRPKEFLSVMVNEAELLEKYDIEIVPGEPTVILDRVDRILAEDRDRMEELLKSLTDAGLDISALGENRYPLAAIELALLDFAEDNDCNALSCECWNLFRKKYGVSPCFILGDLNDRGLPAACENDVHAAITSVMAVAAARYKTPSFVADLTIRHPENDNAELLWHCGSFAKALKKEGAKGCVIREGKGFYELEGGPVTVLRFDGNHGEYYMFAGEAKGVDGPVTNGNYLWIETDNWVKWEKKFIFGPYIHHVVGIHGSYSGIIQEACRYLGIRIDLPDMPNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Z3</accession>
    <name>F7K9Z3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252577.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02676"/>
    <dbReference type="TCDB" id="9.B.325.1.8">
        <property type="family name" value="the putative abc4 (abc4) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40659">
        <property type="protein sequence ID" value="EGN40659"/>
        <property type="gene ID" value="HMPREF0994_02676"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2930"/>
    <dbReference type="eggNOG" id="COG4905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051143_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="442" mass="50375" checksum="C91FEFF407DAC44D" modified="2011-09-21" version="1">MVNIIFELIWYFFIYSFIGWCAEIAYAAVKHKKFMNRGFLNGPLCPVYGIGMVLILVFFSSLKGNFFFLALGCSVMAAVVEFFTGALMEKVFRCKWWDYTGYKHNLGGYICPQFSALWGIGAALIITFVHPFLAPLISMIPTFIVRLLGIILLVITTGDFLSVAGAILQLRKTARIEEIAAGMQEVSDRLGNAIFHGIQKRMTRAFPNLEKDGENALAARFRKKERKESLVFAEGCSFHKLVWLFFIGAFLGDITETIFCRLTSGVWMSRSSVLYGPFSIVWGIGVVVLTMMLHKYRDRDDRYIFIFGTVVGGAYEYVCSVFTEMVFGTVFWDYSKIPFNLGGRINLLYCFFWGLASVLWIKNVYPFLSRWIEKVPEKVGKILSWVFLVFMAVNIVLSGMALARYSDRYGGKPAENSVDSFLDTHYPDERMERVYPNAIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA55</accession>
    <name>F7KA55_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252642.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02741"/>
    <dbReference type="EnsemblBacteria" id="EGN40724">
        <property type="protein sequence ID" value="EGN40724"/>
        <property type="gene ID" value="HMPREF0994_02741"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2998"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="302" mass="34200" checksum="3156C783542C9464" modified="2011-09-21" version="1">MEQNLNLYHIFYTVAKCRNISGAARQLFISQPAISKAISRLEQNLDTTLFLRSSRGVRLTETGELLFRQVESAFQAISQGEEQLRKVQELGMGHLSIGVSTTLCKYVLLPHLSLFTRENPHIQISISCQSTYQTMEALEKGTVDIGLIGENDRMDKFHFHPVQEIRDVFVCTQRYLDNLCKRVSFSGSPSSRDIISHSTLMLLDKENITRQYMEKYLVKEEITAAQTIEITSMDLLIDFAKIDLGIACVIEDFVQEELDTGKLISLPLPVSVPSRKVGFAYLKNQTCSATAEKFSDFCMKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAC7</accession>
    <name>F7KAC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02753"/>
    <dbReference type="EnsemblBacteria" id="EGN40362">
        <property type="protein sequence ID" value="EGN40362"/>
        <property type="gene ID" value="HMPREF0994_02753"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3011"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="53719" checksum="B25F80E8F102734A" modified="2011-09-21" version="1">MTGMEQYIIVYSKYIITLFMLLYCVLAFCRTFSAGWRGHKLDNIQGILIFLIQFIAFLTICVEKGDVDYLFFYAISQIVIFSSMMIFSMAYTGINRLLVNNMCLLLGTGFIILTRLDIAKAGKQLLIAAASLAVSMVVPLFIRRIRFWKDLTWVYAGVGITALGVVLILGQVTHGSKLSFSLGGITFQPSEFVKILFLFCIAAILWEDSSLKNIVISGAVAAAHVLILVLSKDLGSALIFFAAYVFLVFFATGKIRYLLAGGAAGCAASYLAFLLFSHVKVRVQAWQDPWSVIDNQGYQITQSLFAMSRGSWFGLGIGQGTPKDIPFVETDFIFAAITEELGIVFAIGIILICISCFFMILKIAGASSDPFFRLVVSGFGVMYIFQIFLTIGGGTKFIPLTGVTLPLISYGGSSVMTTLILFSVIQGIWLRERDTEEKEERRRLKTSGYYEPYEDDVPEEGEFEEEDWDGNEYEEEYDDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAT6</accession>
    <name>F7KAT6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252866.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02965"/>
    <dbReference type="EnsemblBacteria" id="EGN40343">
        <property type="protein sequence ID" value="EGN40343"/>
        <property type="gene ID" value="HMPREF0994_02965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3236"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019084_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="6">
        <location>
            <begin position="300"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="780" mass="89655" checksum="48DB609E48202ED4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB67</accession>
    <name>F7KB67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03105"/>
    <dbReference type="EnsemblBacteria" id="EGN40282">
        <property type="protein sequence ID" value="EGN40282"/>
        <property type="gene ID" value="HMPREF0994_03105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3395"/>
    <dbReference type="eggNOG" id="COG4461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933135_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363626" evidence="2">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PdaC" evidence="4">
        <location>
            <begin position="93"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="3">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="298" mass="33040" checksum="82489960736AAFFA" modified="2011-09-21" version="1">MKKFMCLTLTAALLLTGCNGKSADGNTGTVAQTESSTVQETPASAETSQETTEAATEETQTSGEKGGLQAGEYTYHLEKEEKTWSTEKGQLACTVKLEYPVFEGDSDGEKKINEFYEEWVSDMMENYENDPDSIVSYAMQYRTEEENSQTAAEGETEAFTMPPSEEDFTVGGVVSHGNLISVYHESYTYEGGAHGMPGRNNHIFDKETGKEVTLASLINLSNDELNTMVRDKFLEVVENDTEGGFFEDAAETLNAKNDFIEYYYLTDEGVVFYTTPYEIAPYAAGYTEVTIPYEELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBB1</accession>
    <name>F7KBB1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YlxR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39970.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360258.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03140"/>
    <dbReference type="EnsemblBacteria" id="EGN39970">
        <property type="protein sequence ID" value="EGN39970"/>
        <property type="gene ID" value="HMPREF0994_03140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147970_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39970.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="90" mass="10341" checksum="A4A3FA0857539D3F" modified="2013-09-18" version="2">MNKKVPMRQCVGCGEMKGKKEMMRVLRTAEGDIVLDVTGKKNGRGAYLCKSMECLKKARKSKGLERSFKMNIPNEVYDSLEREFEEFEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBH7</accession>
    <name>F7KBH7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253112.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03211"/>
    <dbReference type="EnsemblBacteria" id="EGN40041">
        <property type="protein sequence ID" value="EGN40041"/>
        <property type="gene ID" value="HMPREF0994_03211"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3507"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="215"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="518" mass="56672" checksum="58C45BAA7AC6C65C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBL0</accession>
    <name>F7KBL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253147.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40076">
        <property type="protein sequence ID" value="EGN40076"/>
        <property type="gene ID" value="HMPREF0994_03246"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503369K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139025_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="123" mass="13848" checksum="E31578BFF6F360C7" modified="2011-09-21" version="1">MEKMIVCDGNAAEREQLIDLARQCLQGREVQVTGCADWPELDGMVKQALPDAVIVAQDGVEGLNTITSARNLVRRILWFSDMDFREQAYRLCVPFFCRKPVSTQKMEQAISRLINTSPKTGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBS7</accession>
    <name>F7KBS7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253223.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03322"/>
    <dbReference type="EnsemblBacteria" id="EGN40152">
        <property type="protein sequence ID" value="EGN40152"/>
        <property type="gene ID" value="HMPREF0994_03322"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3633"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="13006" checksum="6D739347B6EFD040" modified="2011-09-21" version="1">MNIQIFGKTKCFDTKKAERYFKERGIKYQYIDLKEKGMSKGELNAVCQAGGGLDALLDENCRDKDALALVRYIAEEDRMEKVLENQQVIKTPVVRNGKKATVGYRPEVWKGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC50</accession>
    <name>F7KC50_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253333.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03432"/>
    <dbReference type="EnsemblBacteria" id="EGN39939">
        <property type="protein sequence ID" value="EGN39939"/>
        <property type="gene ID" value="HMPREF0994_03432"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3751"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="379"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="598" mass="68662" checksum="550B52E8ED443E2C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCP8</accession>
    <name>F7KCP8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyco_hydro_2_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253528.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03627"/>
    <dbReference type="EnsemblBacteria" id="EGN38999">
        <property type="protein sequence ID" value="EGN38999"/>
        <property type="gene ID" value="HMPREF0994_03627"/>
    </dbReference>
    <dbReference type="GeneID" id="29728183"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3959"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="4">
        <location>
            <begin position="352"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="884" mass="100879" checksum="78DC5C9C7772597A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCZ7</accession>
    <name>F7KCZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermatogenesis-associated protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03726"/>
    <dbReference type="EnsemblBacteria" id="EGN38890">
        <property type="protein sequence ID" value="EGN38890"/>
        <property type="gene ID" value="HMPREF0994_03726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191186_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="54" mass="6258" checksum="5FF91EBA0E0F1701" modified="2011-09-21" version="1">MNTAENVPNRLINEKSPYLLQHAYNPVDWFPWCEEAFAKAKAEDKPIFLSIGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD33</accession>
    <name>F7KD33_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253663.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03762"/>
    <dbReference type="EnsemblBacteria" id="EGN38827">
        <property type="protein sequence ID" value="EGN38827"/>
        <property type="gene ID" value="HMPREF0994_03762"/>
    </dbReference>
    <dbReference type="GeneID" id="29729553"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="28292" checksum="A4191CF7CCA23499" modified="2011-09-21" version="1">MEKMPIAAQVYSVREEAGADFAGTMQQLKSLGYDGVELAGLYGRTPDEIKGWLEEAGLTPIGAHVPFDEFDKDLESTVRAYHSIGCSYVAIPSITEDRRYGGSRYEEFLAAIPVIAAECRKYGMKLLYHNHGFEFEKTADGKTPLDELYASQSPEDLETELDTCWIKVAGRDPLAYLEKYRMRCPLVHIKDFIQDGEVKLVAVGDGVQDIKAIAEKAQECGAQWLVVEQDSHIFGSPMENMKKSICCLRSMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD89</accession>
    <name>F7KD89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_03818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253719.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03818"/>
    <dbReference type="EnsemblBacteria" id="EGN38583">
        <property type="protein sequence ID" value="EGN38583"/>
        <property type="gene ID" value="HMPREF0994_03818"/>
    </dbReference>
    <dbReference type="GeneID" id="29729405"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4158"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="155"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="359"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN38583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="613" mass="70122" checksum="B0393E1AECFDF7F7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDJ2</accession>
    <name>F7KDJ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03937"/>
    <dbReference type="EnsemblBacteria" id="EGN38702">
        <property type="protein sequence ID" value="EGN38702"/>
        <property type="gene ID" value="HMPREF0994_03937"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4288"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006041_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="272"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="452" mass="53064" checksum="BDA9710339DACA5B" modified="2011-09-21" version="1">MEQGTGKTITALELCRLRLEAGKISHILWLCPCSTKQNLKDELIKQAPREILERTTICGIETLSRSIHANSYLRLLTEQEHCYLVVDESLLIKNPYAYRTQNIDYLSSHCDYKLILNGMPISKNQADLYAQFHILDWRILGYKTYWSFAANHIEFDPEIPQKIIRCLNTDYLARKISPYTVQVTKKDCLVLPDKSYSVNYFSLTRKQNEHYNQVADVLLFHLNELHPESIYRLFAGLQAVTSGFRVLFQRSDTGYEHIVTQPFFENPADNPRLQRLLSVIDNRSKYIIFCNYTYEIDVLCRILAVKYGEEQIARFDGSIPMKKRMQNLETFKTRANFLIANRDCAGYSLNLQFCHNIIYFSNSWDLATRLQSEDRIHRIGQEKDIHIRDICAYNTLDERILGCLYRKEKLLEAFRNDIKNMENKNHIAEWIYCQKQNRGLMDCDDLEEARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDN4</accession>
    <name>F7KDN4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253796.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03895"/>
    <dbReference type="EnsemblBacteria" id="EGN38660">
        <property type="protein sequence ID" value="EGN38660"/>
        <property type="gene ID" value="HMPREF0994_03895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4239"/>
    <dbReference type="eggNOG" id="COG4552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717529_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="377" mass="42217" checksum="648A0BEE887B7605" modified="2011-09-21" version="1">MSEYRIARPEEKDACIELANYVFSTAHCPHDFETLIPKVYGEGVDSAFIHRVAAEENGKLRAQIAVLPEKLMVAGHPLRAGFVGTVSVHPKARGEGHMKRLMQDWLKEMQETCDIAVLDGQRQRYEYFGFTRGGIQIRYTVSSDNIRHALKQTDTRGISFVPLSEAEGAAEFMCRQNEKRPSWVTREPENVLAIAATANEKAVGMKKDGVLAGYLLTCNEGKEIREMAVEQPEDMEKAVKAYMEYAGTEEIMIFASAYDCILNKCIGRFAESYSECPSGMYQIFDFANVLEAYLTLKQRTLGLMPGEFSACLDGQPVTARVTENGVRVERKALPGAITLDKQQAQQLLLSGYDRYMDVPAPAGWFPLPVFWFTADSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDR2</accession>
    <name>F7KDR2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BcrAD_BadFG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253892.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03991"/>
    <dbReference type="EnsemblBacteria" id="EGN37680">
        <property type="protein sequence ID" value="EGN37680"/>
        <property type="gene ID" value="HMPREF0994_03991"/>
    </dbReference>
    <dbReference type="GeneID" id="29729267"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4348"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="11"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="336" mass="37046" checksum="46E7ABF9089267B4" modified="2011-09-21" version="1">MEEGYYTLSADGGGSKLIVTVFDDDFHFRAAGYGGPVNGCFSIEEKRRQIEEALSECLAEVPPGRIRRAFLAAPWMGKQEDLAENDIFFQEVKKHSPNVLCCPLNEGEACLLAGSFRREGTVVLSGTGSGIFQVGSGEAHLGGWGYLLGDFGSGFFIGQKGLQAAIRGEEKWGKETCLGDFARQAYGVKRLWDLLHVIYEDSFAVKQVASFCRWVGMAADNGDEAALEILYEAACELSGQAAVMLRNAEQQEPFVLAAGGAWKSSSFLFQSFSEQLKVQIPSARIRKPVFEPVMGGVILSLLEKQEGDATERLEELKKEFPQFLIRNWEKEEINVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDR5</accession>
    <name>F7KDR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03994"/>
    <dbReference type="EnsemblBacteria" id="EGN37683">
        <property type="protein sequence ID" value="EGN37683"/>
        <property type="gene ID" value="HMPREF0994_03994"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4351"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033229_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356543" evidence="2">
        <location>
            <begin position="29"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="585" mass="65297" checksum="799107F112E3A926" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDV1</accession>
    <name>F7KDV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253931.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04030"/>
    <dbReference type="EnsemblBacteria" id="EGN37719">
        <property type="protein sequence ID" value="EGN37719"/>
        <property type="gene ID" value="HMPREF0994_04030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4394"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002707_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN37719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="796" mass="90527" checksum="54AA94DEB2AD9638" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDV5</accession>
    <name>F7KDV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04034"/>
    <dbReference type="EnsemblBacteria" id="EGN37723">
        <property type="protein sequence ID" value="EGN37723"/>
        <property type="gene ID" value="HMPREF0994_04034"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4399"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="4">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="4">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN37723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="33986" checksum="A8984333F6261759" modified="2011-09-21" version="1">MMTKNNTLQGHLAAFLTIFVWGTTFISTKVLLKSFGPIEILFIRFLIGYLALWIGCPHRKRKGERKEELYFAVAGLCGVTLYFLLENIALTYTYASNVGVIISIAPFFTAIFSFLLKKEEKPGKRFFLGFIMAMAGIFLISGFGGLNPFGDLLAVGAAILWAAYSLLTRKISDFGYPVVQATRRTFFYGLVFMIPALFLMDFHVEPRLFLEPANAGNLLFLGLGASALCFVTWNFAVRVLGSIKTSVYIYMVPVVTTVTSALILKEKITAVSAVGILLTLGGLFLSQKWGKEGGDSPAAAEEIGETGESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDY6</accession>
    <name>F7KDY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253966.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04065"/>
    <dbReference type="EnsemblBacteria" id="EGN37101">
        <property type="protein sequence ID" value="EGN37101"/>
        <property type="gene ID" value="HMPREF0994_04065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100916_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="174" mass="20048" checksum="CD2A6BE319285F1D" modified="2011-09-21" version="1">MNQQEFIRVVMNPVRQRIIQYLILHEEGTAASFKEELNDIPTASLYRHIKVLYEAGCIEVIRECRKRGTVEKTYALVKQPLGEGDRKSVEGLIQSALFSLMASFTGYFADEGNDFRKDMLSLTTSTLLLTDEEYMEMSGKIGAVFNEYIYNKPEEGRRPRRITFISSPCEEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE24</accession>
    <name>F7KE24_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254004.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04103"/>
    <dbReference type="EnsemblBacteria" id="EGN36896">
        <property type="protein sequence ID" value="EGN36896"/>
        <property type="gene ID" value="HMPREF0994_04103"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4475"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="29217" checksum="B39CC63D835E31AF" modified="2011-09-21" version="1">MRQDSSAIGWKQEDEEWIALAQSNDFRMFFIMPYTLEYLGDVRGMDILDLGCGEGGYSRELAAAGARVYSVDSSSFFIEYAAEKALEECLDIRHFVRNSDDLYGIPEESFDRVLCSMMLMDCEDLQGTLREIMRVLKPGGKLVASVLHPCFYGKEITWSGDDTEKKVTVEDYFHPVLWERALYKDVDKPVIWRHRTLQDYVKSFVACGFSVTDLTEPIPTQNQIKKFPGLDWLQKIPLFLFWELEKKRGGNGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEA9</accession>
    <name>F7KEA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04188"/>
    <dbReference type="EnsemblBacteria" id="EGN36468">
        <property type="protein sequence ID" value="EGN36468"/>
        <property type="gene ID" value="HMPREF0994_04188"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4569"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055069_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="153"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="346" mass="39668" checksum="48D1E10A1CCB36DB" modified="2011-09-21" version="1">MRKVLLYNGGMNVAGKSGVGRAMEHQARALESAGIPYTFDPKEDYDVVHLNTVFPDSLWMSLKARMEGKRVVYYGHSTMEDFRNSFIGSNMAAGLFRRWIRRCYRSGDVVITPTPYSARLLQTYGINREIVPLSNGIDLAAYKKSEEGAERFRRAYCFTSTQKVVLGVGHYIERKGILDFVEMARKYPQYEFIWFGSTPSALIPSRIRKAVRTQLPNLQFPGFISKEELMDAYSGSDLFFFPTLEETEGIVMLEAMAMQTPVLVRDIPVYEGWLEHDRTVYKGKGREDFEQLLPVILEKQLPDLTQEAYQLVRENSITKIGTALAEIYDSLFEEGTYENINYNRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEJ4</accession>
    <name>F7KEJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254138.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04237"/>
    <dbReference type="EnsemblBacteria" id="EGN36517">
        <property type="protein sequence ID" value="EGN36517"/>
        <property type="gene ID" value="HMPREF0994_04237"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4626"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052940_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="413" mass="45639" checksum="55607A5BB3AB1757" modified="2011-09-21" version="1">MRLFRLELKRVIKTRTTWILLAAALLISVLMAWLPVTFETRNVVEDGVEKELTGFDAIRVKRQAQAGIAGEITEAQLKAAAETAVRVLREYEKEYMYQLPTEVYVEKILPVAPLLSRVPEVYADAETGMAPGIAALDPDWLDHFYESCPVHLKNLMKLEQRDYPEAGEKAEKMYAKVKMPFVFYPGYSTNAYDYQMLTIFLLVLLCVIIAAPIYSAEYQTHADDILRCAKYGKGKLAVIKLAAAVLITAVSFALCMALHLILSNSFFGWDFLKSSMQLVFSTVSLSAMTIGQLQLAVAAAGFASLLASVSFTLFLSSRCQNTVAALALALLFFLSPIILFMASGGNGISWLRCLLPSGGVSILGGFASEMTDFNFLHIGSRCVWTPYVILVAALVEIPVFTGLTIRSYCRHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF32</accession>
    <name>F7KF32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35784.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359936.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04474"/>
    <dbReference type="EnsemblBacteria" id="EGN35784">
        <property type="protein sequence ID" value="EGN35784"/>
        <property type="gene ID" value="HMPREF0994_04474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356842" evidence="2">
        <location>
            <begin position="33"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35784.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="585" mass="65127" checksum="54BD6530072BA518" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFG0</accession>
    <name>F7KFG0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_04589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254490.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04589"/>
    <dbReference type="EnsemblBacteria" id="EGN35036">
        <property type="protein sequence ID" value="EGN35036"/>
        <property type="gene ID" value="HMPREF0994_04589"/>
    </dbReference>
    <dbReference type="GeneID" id="29723739"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5010"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="6">
        <location>
            <begin position="207"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="7">
        <location>
            <begin position="302"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="9">
        <location>
            <begin position="625"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="10">
        <location>
            <begin position="718"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="826" mass="92867" checksum="242E4F9BFADFE4D2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFL3</accession>
    <name>F7KFL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254543.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04642"/>
    <dbReference type="EnsemblBacteria" id="EGN35089">
        <property type="protein sequence ID" value="EGN35089"/>
        <property type="gene ID" value="HMPREF0994_04642"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5070"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN35089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="324" mass="35600" checksum="33D80530391D6359" modified="2011-09-21" version="1">MSHLLEVNGLTTAFTGDYGKTVSVDHVDFYVDEGEVVCIVGESGCGKSVTSLSIMGLLGRGGAVIDGSVLFDGKNLLEMGEKELDEIRGNRITMIFQDPLTSLNPVFTVGNQITESIRKHLHLSKEEAAKRAESVLEKVGMPDAHAAMKKYPHTLSGGMRQRAMIAMALCCNPALLIADEPTTALDVTIQAQIMSLLKELREEIGMSIILITHDIGLVASMADRVLVMYAGQIIEEAPAKEIFRAPRHPYTKALLATVPSIYDGDDRELVSIPGIVPEGYDDIPGCRFADRCEYRRPECDKPQENYSFGEKHRAKCVVMKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFM6</accession>
    <name>F7KFM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254556.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04655"/>
    <dbReference type="EnsemblBacteria" id="EGN34866">
        <property type="protein sequence ID" value="EGN34866"/>
        <property type="gene ID" value="HMPREF0994_04655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5085"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="262"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="494" mass="54446" checksum="379819A93A2F3CE8" modified="2011-09-21" version="1">MKQEYIISIDQSTQGTKALLFDCEGKLLFREDLPHKQLVNEQGWVSHDLWEIRDNTIRAAKLLMEKASVSPGLIAAVGISNQRETTAMWDRKTGEPLEHAVVWQCGRAAGIVRDIAKKGFGSIIREKTGIPLSAYFPAAKMAWLLQKNAEIRERAESGEICLGTIDSWLLWQLTQEHVFKTDYSNASRTQLMNLQTLGWDEELAEIFGIPMECLPQICDSDSVFGYTLMGGLFEKPVPICAVLGDSHAALFGQGCLLPGMSKATYGTGSSLMMNIGEKPIASSHGVVTSLAWKRRGRVEYVLEGNLNYTGAVITWLKEDMKLIQTAGETEELALSANPADETYLVPAFTGLGAPYWDENARAAVIGMSRVTGKAELVRAALDCIAYQITDLIMAMEQDTGIPMKELRVDGGPTRNRYLMQFQSDISGKKLRIPAEEELSGIGAAYMAGIAAGLYQEEVLFGRENGTEFIPEMDEMVRKQKQEGWKAAVAKVTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFR0</accession>
    <name>F7KFR0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04689"/>
    <dbReference type="EnsemblBacteria" id="EGN34615">
        <property type="protein sequence ID" value="EGN34615"/>
        <property type="gene ID" value="HMPREF0994_04689"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50326IM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1649204_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="162" mass="18217" checksum="1536D6ADB7A843C0" modified="2011-09-21" version="1">MQMNINILLIIALALCLWRAYRGFRVGMAEEIYRLISLVVALFVLALSIMAISSFMDHNNKNGIVAVILIIITGIVFHLLSIVLNSLKTVAKLPIISFFNSILGIAAGVLEVAVALWILYIIIQNFPTGSFGEQIMKWTNENEWLLRLYNSNYISGWISPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG14</accession>
    <name>F7KG14_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254694.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04793"/>
    <dbReference type="EnsemblBacteria" id="EGN34420">
        <property type="protein sequence ID" value="EGN34420"/>
        <property type="gene ID" value="HMPREF0994_04793"/>
    </dbReference>
    <dbReference type="GeneID" id="29728064"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5235"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356612" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="381"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="517" mass="56693" checksum="441D3118690B0DD9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG25</accession>
    <name>F7KG25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04804"/>
    <dbReference type="EnsemblBacteria" id="EGN34431">
        <property type="protein sequence ID" value="EGN34431"/>
        <property type="gene ID" value="HMPREF0994_04804"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2180449_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357379" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="109" mass="12528" checksum="FC21CBE52C948F42" modified="2011-09-21" version="1">MRALPGALRRGLLFMFSPCCLKFPSAPPSSPGLSELYRLLYDKVPYRARFRSDNYAAVLRLQNTQPKDRRIYTALTGILVVQQPVQLRKAGRGRRSRWKLQAARGKHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG36</accession>
    <name>F7KG36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254716.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04815"/>
    <dbReference type="EnsemblBacteria" id="EGN34442">
        <property type="protein sequence ID" value="EGN34442"/>
        <property type="gene ID" value="HMPREF0994_04815"/>
    </dbReference>
    <dbReference type="GeneID" id="29728061"/>
    <dbReference type="eggNOG" id="ENOG502ZXCA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1427137_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="187" mass="21588" checksum="72ACD40C27719CA2" modified="2011-09-21" version="1">MYYHASPIKDLHILTPHTSNHGTPLLYLSAKRENTLPYLSNAIELYGKRSGKFPEGPYHKWASYGFTGEGILRLEEYYPNAAEETYKGISGYIYTIAPSPDIKKQQDIPYAYTSEYSMPPVSCEYIPDAYEAILTAARDHKIIIQKYEDNSASKLQWIEKTIKEQFTHTQKPEYKAFLQAQFPFLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG55</accession>
    <name>F7KG55_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254735.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04834"/>
    <dbReference type="EnsemblBacteria" id="EGN34461">
        <property type="protein sequence ID" value="EGN34461"/>
        <property type="gene ID" value="HMPREF0994_04834"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020211_13_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="331"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="436" mass="51073" checksum="7E4A1256A8C04E4C" modified="2011-09-21" version="1">MTGFQIIQALLTITEISGLFYLFFLMYERRSGRLWSSLLLGILIAGFCASAIFQRGEVAMYSRYFMLFCIGVTVILLKLFFRLKTSDGFIITALYYETIYFLDIILGYLGQLLSGRTEFIITAQLHVNRDRIIIMVLSRLITLIIILLIIYNRGRFRLLLTKYKLIVFILVVLEYIGLFYCDEILNITVYRNKRIDIYFVFFPLLILFILVTMIVFVLYIEKKNEVKLFQTHNNMVKKSYREMLYLYQNRDRIFHDMQNHILILSSMLEENNLEAAKNYISKIQDPIKELQQKKYTGNHIVNIIMNDKMKKAERCAITVNIRELEVYENNIEDIDWCCMLANLLDNAIEGCQKITENKRKIELYLVQRNGTIILNISNTYGGDIAAEDNKLLSSKKDALLHGIGMQSVRLAVEKYKGTFEYHFTEECFTVSIALFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGG9</accession>
    <name>F7KGG9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">HMPREF0994_04948</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254849.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04948"/>
    <dbReference type="EnsemblBacteria" id="EGN34117">
        <property type="protein sequence ID" value="EGN34117"/>
        <property type="gene ID" value="HMPREF0994_04948"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5404"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_9"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="105"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="231"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="320" mass="34519" checksum="037549521D7BBCEC" modified="2011-09-21" version="1">MKSRIIGTGSCLPAAKVTNDWLSTKMDTSDEWIVSRTGIRERRIAREETTTDMAEQAARLALEDAGIAPEDLDLILVGTITADHVTPSAACELQARLGAGNAMAFDINAACSGFLFALESADAFLGTGRFRNVLVLGAETLSRIMDWTDRSTCVLFGDGAGAAVVRREDVGILSFDHGCDGSKGDALICRNRGNNNLLVQSDTDLDYVHMDGQEVYKFAVKTVPASIGKALEKAGLQAEDIKYFFLHQANLRILQSVAKRLHISVDKFPVSLDHCGNISAGSVPILLDECNRKGYLEKGDKIVLCGFGAGLSWGTAVMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGY8</accession>
    <name>F7KGY8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_05118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05118"/>
    <dbReference type="EnsemblBacteria" id="EGN33151">
        <property type="protein sequence ID" value="EGN33151"/>
        <property type="gene ID" value="HMPREF0994_05118"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN33151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="404" mass="43242" checksum="2CD059EB3862E745" modified="2011-09-21" version="1">MGKNKESFVNKNYILMIIINTLYTAAMGFATTHLTVHGTTELGMSMTLFGTIASAYSVLCLVMRPISGNLVSRMNPKLIMIVSLGVATLSYLAFAISGNIPLFIMARIIQGIGFGMVGTCLPALVAKSVPRARYSQALGIYMTIPMITGIITPTIIVAAKDALGYSFVCVIAAICAVVAIVCTMLLKFDKVKENENTESIKKEKKKFKLKEAIAIEAWPVVLANIFCGICFTAIMMNLLVFDEKIGLGVFAVWMSLYNGCNMFTRALGGIVADKIGSKKTLLICMLCLAAGLAIFAFTESYVLWLAAAVIYALGHGGFQAPMISACVSCVEQDRAGVATGTMYMGADFGAIIAGTIVGILVDNLGYHNMYAVAMGCAVAAFVVLLAFFHPKETEENMESVKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHM0</accession>
    <name>F7KHM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate butyryltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255192.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05349"/>
    <dbReference type="EnsemblBacteria" id="EGN32790">
        <property type="protein sequence ID" value="EGN32790"/>
        <property type="gene ID" value="HMPREF0994_05349"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5845"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056531_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050182">
        <property type="term" value="F:phosphate butyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014079">
        <property type="entry name" value="Phosphate_butyryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02706">
        <property type="entry name" value="P_butyryltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="80"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="32954" checksum="B0369AF1B2196182" modified="2011-09-21" version="1">MSTSFDGLISKVKECGQKTVSVAVAQDSAVLEAVRAAKDRGIANAILVGDEAKIKAIAEELKIDVSDFEIINEPDEWTAALTAVKLAHDGKADMYMKGLLETKTFLKSILDKEVGLRTGRTLSHVCVFDIPGIEQLLFFTDVAFMTYPTLEDKVHIIENTVEVAHACGIPNPKVAPLAAVEVVNPKMPVTVDAAELTKMNEEGKITGCIVDGPLSLDLAIDEEAARHKGATHRKIQGNADVLLFPDIHAGNLVYKAIVHMVDGVKNGCILTGTKVPAILTSRSDSFETKVNSIALAAVVAEELNKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHX4</accession>
    <name>F7KHX4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255308.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05465"/>
    <dbReference type="EnsemblBacteria" id="EGN32906">
        <property type="protein sequence ID" value="EGN32906"/>
        <property type="gene ID" value="HMPREF0994_05465"/>
    </dbReference>
    <dbReference type="GeneID" id="29727566"/>
    <dbReference type="eggNOG" id="COG2314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081297_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="179" mass="19603" checksum="59F154179AE1B522" modified="2011-09-21" version="1">MNELRCPQCGAPVDAGATECKYCGERLSFQQSAVQPDAGAQQGGYQSGPAYGDGYQQGPGYGNFQGGPQPNPFQGQPQPQVYQVPPQPQGYQQPMPGYYNNPAIDPSWPVKSKLCAGLLGIFLGTFGIHKFYMGKVGMGILYICFCWTYIPAIVGFIEGIMYLCSSDENFMLKHHVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI35</accession>
    <name>F7KI35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tnp_DDE_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255235.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN32833">
        <property type="protein sequence ID" value="EGN32833"/>
        <property type="gene ID" value="HMPREF0994_05392"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5895"/>
    <dbReference type="eggNOG" id="COG3666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021293_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="434"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="584" mass="68745" checksum="DBEF166B31DACE77" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI39</accession>
    <name>F7KI39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255249.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05406"/>
    <dbReference type="EnsemblBacteria" id="EGN32847">
        <property type="protein sequence ID" value="EGN32847"/>
        <property type="gene ID" value="HMPREF0994_05406"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5909"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="32809" checksum="2048C99BEFB2D317" modified="2011-09-21" version="1">MDKVRKNKTALIIFLLPATILFVIIIIVPIFMSCYYSLLKWDGMTTGKFVGFDNYINLFKDTSIQFPKTLWHAVVIAIFSVFIQLPISLGLALILAKGIKGERFFLSVFFIPVLISSVVIGQLWLKIYNPNYGLLNTFLKTVGLSGWVHTWLGEEKTALAAVMVPILWQFIGYHMLLFYAGIKSVPRELIEAAQVDSATSWQINTRIIIPQIKPIIRMCTIFAVVGSFKTFDMIYVLTNGGPSHASEVPSTLMINLIFGRNQYGLGSAVAVIIIILCFAFAIGIKRIFKVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIQ2</accession>
    <name>F7KIQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05739"/>
    <dbReference type="EnsemblBacteria" id="EGN32228">
        <property type="protein sequence ID" value="EGN32228"/>
        <property type="gene ID" value="HMPREF0994_05739"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6276"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_11_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="26610" checksum="C3480F94420F5532" modified="2011-09-21" version="1">MVELCYATSKSPMKDFVYGGVIVSNNDCHMDTYKPAEKPMSYGGNNHGSIVEIRGKWYIFYHRHTDGTNFSRQGCIEPISFREDGSIVQAEITSCGANGGPLEGKGEYPAYLACHLFTGDEAFTTGAPGEWMDCRFPKITQDGRDGDEETGYIANMRNGAHAGFKYFACKGISRVSIRVRGYCKGAFGVKTAWDGPVLGWIPVEFSNEWKEYGAAIAIPDGVQALYFVYQGDGGASLASFCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIT5</accession>
    <name>F7KIT5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002585088.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05748"/>
    <dbReference type="EnsemblBacteria" id="EGN32237">
        <property type="protein sequence ID" value="EGN32237"/>
        <property type="gene ID" value="HMPREF0994_05748"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6285"/>
    <dbReference type="eggNOG" id="ENOG503150Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2449886_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="83" mass="9598" checksum="3C8EC25350B551CC" modified="2011-09-21" version="1">MENQKMPEYETIRAAVAGEKWAVEKVVECYKDEIDRLSTVAVRQPDGSTKQEINEDMRQSITKKLIEALPQFPLEEMEKGNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIT8</accession>
    <name>F7KIT8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IstB_IS21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000013">
        <property type="protein sequence ID" value="EGN31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255551.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05767"/>
    <dbReference type="EnsemblBacteria" id="EGN31908">
        <property type="protein sequence ID" value="EGN31908"/>
        <property type="gene ID" value="HMPREF0994_05767"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6305"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="2">
        <location>
            <begin position="122"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="32499" checksum="02A64C35A47FE940" modified="2011-09-21" version="1">MKNEIEAMITDITTTTTEAEDYTGEDGLLYCGKCHTPKEAYFAEGKTCFGRDRHPTDCDCQRAAREKQQAAESRQKHLEKVEDLKRRGFTDPAMRNWTFEHDNGRNPQTETARFYVESWETMQAENIGYLFWGGVGTGKSYLAACIANALMEQEVPVCMTNFATILGDLAASFEGRNEYISRLCSYPLLILDDFGMERGTEYGLEQVYSVIDSRYRSGKPLIATTNLTLEELQHPQDTPHARIYDRLTSMCAPVRFTGSNFRKETAQEKLERLKQLMKQRKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIX8</accession>
    <name>F7KIX8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein (Beta-ribbon, CspA family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255583.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05807"/>
    <dbReference type="EnsemblBacteria" id="EGN31883">
        <property type="protein sequence ID" value="EGN31883"/>
        <property type="gene ID" value="HMPREF0994_05807"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6350"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="66" mass="7242" checksum="8B358520AE7B1F00" modified="2011-09-21" version="1">MNKGTVKWFNNQKGYGFISDEAGQDVFVHYSGLNMDGFKSLDEGAAVEYDVIQGEKGPQAVNVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJK9</accession>
    <name>F7KJK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255819.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06043"/>
    <dbReference type="EnsemblBacteria" id="EGN31397">
        <property type="protein sequence ID" value="EGN31397"/>
        <property type="gene ID" value="HMPREF0994_06043"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6615"/>
    <dbReference type="eggNOG" id="COG0864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170247_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023860">
        <property type="entry name" value="FeFe-hyd_TM1266"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03959">
        <property type="entry name" value="hyd_TM1266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="9204" checksum="4C1202636FC5AD16" modified="2011-09-21" version="1">MEERVAIIGIFITDSSAAAKVNDLLHEYSDCIIGRMGVPCREKSMNIISIIVSAEPGRISALSGRLGRIEGISSKAMQAQVKPGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJR9</accession>
    <name>F7KJR9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255874.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06098"/>
    <dbReference type="EnsemblBacteria" id="EGN30724">
        <property type="protein sequence ID" value="EGN30724"/>
        <property type="gene ID" value="HMPREF0994_06098"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6679"/>
    <dbReference type="eggNOG" id="COG1402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN30724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="31558" checksum="5723BCB4EDCA9638" modified="2011-09-21" version="1">MNYSIFTDTMADLDWREIENKGRQKVPVLFPLGVIEEHGPHLPLGTDIYLSYAICKMIKDMVCAQQGDCLIAPPYYWGVNHCTGSFPGTFSLKPETMIVVLTEIFGNLHQFGFDKVYCINQHGDAVHVKTIIDAIKAANKNFDMHIRLLMEPFDLPQQGLSGKENYILLDEAEYSPELFAEDDIDEKTLLDIHAGALETAAMLNFYPDAVCQDTAKQLKSYSLTENSLDVWLAGGEKVRSVVPLGYAGNPAGYEKKVSTAKVIFEKLADYCAQKIMEDNLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJU6</accession>
    <name>F7KJU6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255901.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06125"/>
    <dbReference type="EnsemblBacteria" id="EGN30751">
        <property type="protein sequence ID" value="EGN30751"/>
        <property type="gene ID" value="HMPREF0994_06125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6707"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078717_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="206" mass="23955" checksum="4643420A623970ED" modified="2011-09-21" version="1">MKITLREYQKEDFQELENIIRETWHYDEFSSSETAARLARVFLNSCLTNHTFSRVAVWNGKPVGIILCKITAGYKCPLKYRAAQIKSILSLYLSKEGRNVSKIFGNVNGIDKQLLTDTGKSYPAELALFAVDPSCRGKGIGKMLFQAVLDYLKEQKLDEFYLFSDTSCNYGFYEHQRMRRRCEKEHIFNINGQTAKMSFFIYEYHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK32</accession>
    <name>F7KK32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256003.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06227"/>
    <dbReference type="EnsemblBacteria" id="EGN30720">
        <property type="protein sequence ID" value="EGN30720"/>
        <property type="gene ID" value="HMPREF0994_06227"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086622_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="27221" checksum="CA08C6882F07B091" modified="2011-09-21" version="1">MLFSCMRAELMKLKRSFIWVVFLILPLISTVMGCANYLQNVEILDSLWYSLWTQTTLFYSNFFFGPLIAVYCAYLWRVENFNHNRNALMTAPVPIPILYLSQFLAIACVTLLTQLWVGVLYFISGRAVGMAGFPPIQTCFWLLRGCLGGLAIAALQLLLSSFIRSFALPIAIALLGSIAGLLFSSRDLGLYCPYSLMLLGMNSNREEDILSGSSLPFLLSCTIFLLLFVLLEIGYLKKSDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK95</accession>
    <name>F7KK95_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RepA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006772917.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06274"/>
    <dbReference type="EnsemblBacteria" id="EGN30193">
        <property type="protein sequence ID" value="EGN30193"/>
        <property type="gene ID" value="HMPREF0994_06274"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6877"/>
    <dbReference type="eggNOG" id="ENOG502ZBMV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051810_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010724">
        <property type="entry name" value="RepA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06970">
        <property type="entry name" value="RepA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepA_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="15087" checksum="7395C90145F60C99" modified="2011-09-21" version="1">MANTIYIHQPEKAVSFTRLPNFLFEAPTFTPLSNEAKVLYAFILRRTDLSRKNGWADEYGRIYLYYPINEVVELLHCGRQKAVNTLRELQYAGLVEIQKQGCGKPNRIYPKSYEAVSNTDFKKSGYGTPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKA3</accession>
    <name>F7KKA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256052.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06282"/>
    <dbReference type="EnsemblBacteria" id="EGN30201">
        <property type="protein sequence ID" value="EGN30201"/>
        <property type="gene ID" value="HMPREF0994_06282"/>
    </dbReference>
    <dbReference type="GeneID" id="29724322"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538257_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363854" evidence="2">
        <location>
            <begin position="26"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="553" mass="62151" checksum="D294A489757A4E8E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKU6</accession>
    <name>F7KKU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin III family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256237.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06475"/>
    <dbReference type="EnsemblBacteria" id="EGN47610">
        <property type="protein sequence ID" value="EGN47610"/>
        <property type="gene ID" value="HMPREF0994_06475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7090"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051078_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="216" mass="23744" checksum="905CAAB65E8879BC" modified="2011-09-21" version="1">MSVTIREPGSAITHLIGMMMAIIASTPLLIKAVLSGQPEVFAAMIIFIASMVLLYGASATYHSINAGGRILRVFRKIDHMMIFVLIAGSYTPICLVVLGGKLGYTLLAVVWGVAILGMTIKAVWITCPKWFSSVIYIAMGWICLAVFGQLWNTLPRAAFIWLLAGGLIYTIGGIIYALKLPIFNSKHKYFGSHEIFHLFVMGGSICHFIFMFKYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKZ1</accession>
    <name>F7KKZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256282.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06520"/>
    <dbReference type="EnsemblBacteria" id="EGN47239">
        <property type="protein sequence ID" value="EGN47239"/>
        <property type="gene ID" value="HMPREF0994_06520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7142"/>
    <dbReference type="eggNOG" id="COG0579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="397"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="478" mass="51200" checksum="526CD51FAD1EFCA6" modified="2011-09-21" version="1">MLDVIVIGAGVTGCATARELSRYDLKAAVLEREEDVCCGTSKANSAIIHAGYDAEPGTLKARMNVQGNRMMDALSKELDFPFKRNGSLVLCFDEDNLPGLEELRERAEANGVPDVRIVAGDEIKALEPNLSPDVKAVLYAPTGGIVCPFKMTIALAENSYVNGVDFHFNTEVTDITRTAEGYLVHTAKGDFAARCVVNAAGVYADQFNNMVSAHKLHITPRKGEYILMDKKAGDFVTHTIFQQPTRLGKGILVTPTVHGNLLAGPTAEDITDKEEVCTTGEGLAQVVDKARLSAEKIPLNMAITSFAGLRACEEKGDFVLGEAEDAEGFYNAAGIDSPGLSSAPAIGLFLAEQIAGKLNAVKKTGFISERKDIPCVAESTPEEIAALIASDPAYGNVICRCEMVTEGEIVNAVRRPLGAKSLDGVKRRTRAGMGRCQSGFCSPRVMEILSRELQVSPMELTKAGGESYLLTGTTKEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL20</accession>
    <name>F7KL20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256311.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06549"/>
    <dbReference type="EnsemblBacteria" id="EGN47268">
        <property type="protein sequence ID" value="EGN47268"/>
        <property type="gene ID" value="HMPREF0994_06549"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7171"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="177"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="707" mass="80338" checksum="172D99167F1FCBA4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL72</accession>
    <name>F7KL72_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5720 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06605"/>
    <dbReference type="EnsemblBacteria" id="EGN47324">
        <property type="protein sequence ID" value="EGN47324"/>
        <property type="gene ID" value="HMPREF0994_06605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7228"/>
    <dbReference type="eggNOG" id="ENOG502ZYHN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173944_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043778">
        <property type="entry name" value="DUF5720"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18987">
        <property type="entry name" value="DUF5720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5720" evidence="1">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="112" mass="12982" checksum="BC7C245897254C9D" modified="2011-09-21" version="1">MRVGKEVSFMPEGKTIGQLMEEMRQKAGAQNYHGHDYMDLQRFAENTRHMIIFDVLTHDSPVGWKGERTRLFLSDKGYEKALDSQAKGQIKILSHAKVRNGDLLYDRSEQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLD9</accession>
    <name>F7KLD9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256421.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06668"/>
    <dbReference type="EnsemblBacteria" id="EGN46592">
        <property type="protein sequence ID" value="EGN46592"/>
        <property type="gene ID" value="HMPREF0994_06668"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="270" mass="31271" checksum="19A0ABB230C86263" modified="2011-09-21" version="1">MKYELHNDLDADFPLIFGCRILSASHPDDAYLHWHDCIEVVYCEYGQGWVISGSDRIFVKEGDIAIVNSGDIHDGFTESECRMYSLDLGSTLYSPLGLDPHLFVFKKKIKDARMEASIRRIIAEMERKDAYYRQAVQIEIMSIVILLMREYLDNTTERKSSDNQQVQAVKKIISYLREHFLERITIEELCTETDYSKFYLCHSFKKMTGNTIIQYVNFLKCQYARNLLLEGNHSVSESAALSGFNNDSYFSKTYKAVFGRLPSDDLRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLE1</accession>
    <name>F7KLE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256423.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06670"/>
    <dbReference type="EnsemblBacteria" id="EGN46594">
        <property type="protein sequence ID" value="EGN46594"/>
        <property type="gene ID" value="HMPREF0994_06670"/>
    </dbReference>
    <dbReference type="GeneID" id="29725574"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335842_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="204" mass="23704" checksum="8A951B7406E0049C" modified="2011-09-21" version="1">MLHFVSKVKEVGIGNCIVGILKRERYKRLSKRYHFDSWHTSPYELRKYIQAAAEYMNANHAEVVVDIGCGLGEMLHHINAKVKIGFDIHEEPIRAAKMLSKDNSTYYVGSFDEVNLQEPVDYLTALNFMHGSTEQTWISCFHNLAERNDIRNFIVDTIPEGYYNAHSLNYRIILPDNYKLVDRIGPFLGGRFLEVYRKENQVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLP2</accession>
    <name>F7KLP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256524.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06771"/>
    <dbReference type="EnsemblBacteria" id="EGN46363">
        <property type="protein sequence ID" value="EGN46363"/>
        <property type="gene ID" value="HMPREF0994_06771"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7397"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="137" mass="15590" checksum="DE781B23EBD79CF4" modified="2011-09-21" version="1">MKDEACIFCKIANGEIPSKTLYEDEKYRVILDLGPAARGHALILPKDHYANLYELPDEACGEVMMLAKKMAVRMTEKLGCSGFNLVQNNGECAGQTVNHFHLHLIPRYEDDNQNINWVPGKPEQEELEEIRKLICED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSA9</accession>
    <name>S2KSA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_07173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360087.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07173"/>
    <dbReference type="EnsemblBacteria" id="EPC05177">
        <property type="protein sequence ID" value="EPC05177"/>
        <property type="gene ID" value="HMPREF0994_07173"/>
    </dbReference>
    <dbReference type="GeneID" id="29727279"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010964_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="823"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="318"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EPC05177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="897" mass="100000" checksum="3938A82DFE0ED95C" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSD2</accession>
    <name>S2KSD2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359864.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05379">
        <property type="protein sequence ID" value="EPC05379"/>
        <property type="gene ID" value="HMPREF0994_07047"/>
    </dbReference>
    <dbReference type="GeneID" id="29724700"/>
    <dbReference type="HOGENOM" id="CLU_1198534_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="231" mass="25652" checksum="FFB5C07D8DF7BA4B" modified="2013-09-18" version="1">MRGQYIRKMKCLYDNKEKCRRNLWVETAAAEAAEREVLQEAVPLLEEALLQEAVLQEAVGSAEGERHVYLPAAVLHRGVAVRLQETAVLHRGTGLHQGTAAVRHQAEAAGREQEAAVYRQEAAQRQGAAGVLPVSLRGIRHLTGVKAVSGGRPRRPASLLITDRLSIMAGIMADTHRRHLEEIRRLEDILLRPEETPCRHPEDIHHRRQGYLDRPDHRGKGGSVTVLVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSY8</accession>
    <name>S2KSY8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH43_C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_07030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359837.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07030"/>
    <dbReference type="EnsemblBacteria" id="EPC05362">
        <property type="protein sequence ID" value="EPC05362"/>
        <property type="gene ID" value="HMPREF0994_07030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="5">
        <location>
            <begin position="314"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="516" mass="58583" checksum="185FE2D59347EF2B" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVP9</accession>
    <name>S2KVP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000014">
        <property type="protein sequence ID" value="EPC05070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07281"/>
    <dbReference type="EnsemblBacteria" id="EPC05070">
        <property type="protein sequence ID" value="EPC05070"/>
        <property type="gene ID" value="HMPREF0994_07281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1237287_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="209" mass="23593" checksum="80E82C36F56409F4" modified="2013-09-18" version="1" fragment="single">RRTIRQALSQACSFDEFSSLLLREGVTVKESRGRLSYLTPDRTKPITARKLGDDFDKAAVLALLTQNARRAAEQTTAMPEYPHTQKERLREEKAAKTIPADNTLQRMVDREAKRAEGKGVGYDRWAAKHNLKQMAATVTAYQQYGFSSPEELDEACSAAYAAMRESLTELKQVEKTLDGKKELQRQVLAYSKTRPVRDGLKQQKNAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVS9</accession>
    <name>S2KVS9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MJ0936 family phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07254"/>
    <dbReference type="EnsemblBacteria" id="EPC05105">
        <property type="protein sequence ID" value="EPC05105"/>
        <property type="gene ID" value="HMPREF0994_07254"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="292" mass="33918" checksum="095AE71AF7887C16" modified="2013-09-18" version="1">MNLQTENRLDIAVLSDIHGNYVALESCLAHAVSQNIKTFLFLGDYVSELAYPERTMKLLYEMDRTCSCRFIRGNKEEYWFQYRAGGEQGWEDGSSTSGAMLYTYRSLTPEDMDFFDKMPISQKIQLEGFTAFTACHGSPFKVNEKMLPEDENTRQIMERTETPLILFGHTHVQRKIEYQGRIALNPGSVGIPLYSSGMTQYMILHGENGCWREEFISLPYDTDRVIREMHEADMYRHAPYWSRITEKILQEGRVSHGTVLGRVMELCREETGRCNWPDIPEKYWEQAIGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>S2L9Y9</accession>
    <name>S2L9Y9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07230"/>
    <dbReference type="ESTHER" id="9firm-s2l9y9">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05081">
        <property type="protein sequence ID" value="EPC05081"/>
        <property type="gene ID" value="HMPREF0994_07230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="496" mass="55368" checksum="E6E10C7928A7A72A" modified="2013-09-18" version="1">MSDYIVQTTAGRVQGHEENGQIAFLGIPYAKPPAGELRLKRAVPAEPWKGVLNAGKFGDKAVQFNDGSCEGSEDCLTLNIRRPSEGEKLPVLVYIHGGGYNTGCASDELYHGKSFANYGIVYVSIQYRLNVFGFYDVTGYPGCGDFDSNCGLSDQILAMQWIHENISAFGGDPEKVTIAGESAGGTSMIALMAAPAVKGTFQQVIASSALPECFFSRETAKRNMDIFLEGMGWSPEDLVKLKDIDAYEALKGNEYVAKEHQYRNPGIFLPTVSVDDLLPERPLDAIAGGSAAGIRLMIGTNLHEGTMFVHPEHTNFPNSWEMIRKMFEENGNTSGYQKIKEYYEKGNGIKVNGVDMAFVDFATDYAFQMPALKVAEAQKKYGQVWMYRFEFMSKMAEKTGMLCSHAMDLPCDFNCPEYGFSAFVFQEEPKEAVDRIVKDVHLRWVSFIKTGNPDSAWPQYTGYKSPVMIYDRETHVEQLDRTELMDVWGDMRFYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAS3</accession>
    <name>S2LAS3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359711.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06959"/>
    <dbReference type="EnsemblBacteria" id="EPC05291">
        <property type="protein sequence ID" value="EPC05291"/>
        <property type="gene ID" value="HMPREF0994_06959"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="250"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="388" mass="43211" checksum="6BD6E74FC687F934" modified="2013-09-18" version="1">MNTTELRPGIYAVGVVDWNVRSFHGYTTNRGATYNAYLIVDEKIALIDTVKAPFAAELLERVREIIDPARIDYLVSNHVEMDHSGAIPAVMEAAPDAVIVTSSPSGLNGLKMHYGDSYEYMPVKAGDSLSLGRHTLQFVPTPMLHWPDNMVTYCPEEKILFSNDAFGQHYSSSKRYDDEVDLAEVMAEAEKYYANILMPYGMQMKKTIPVIEGLDISLIAPSHGVMWRNHIGDIIKAYKHYCDETPDKKAVVVFDSMWHSTERMARAVVEGFAMKGVPVKLYDLKVDHISDIMTDVLKAEYIAVGSPTMNNQMLPTVASFLCYMKGLAPKNKKAFAFGSYGWGGQSAGLVNAELEACKFHILMDPVKIQYVPSEESLKELSDKVAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2D2</accession>
    <name>F7K2D2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MobA_MobL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MobA/MobL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249960.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00011"/>
    <dbReference type="EnsemblBacteria" id="EGN48244">
        <property type="protein sequence ID" value="EGN48244"/>
        <property type="gene ID" value="HMPREF0994_00011"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.13"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025383_5_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005053">
        <property type="entry name" value="MobA_MobL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03389">
        <property type="entry name" value="MobA_MobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0184">Conjugation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobA_MobL" evidence="4">
        <location>
            <begin position="17"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN48244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="529" mass="61235" checksum="42AEA7C5D2C257E3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2D4</accession>
    <name>F7K2D4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00013"/>
    <dbReference type="EnsemblBacteria" id="EGN48246">
        <property type="protein sequence ID" value="EGN48246"/>
        <property type="gene ID" value="HMPREF0994_00013"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.15"/>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031869_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="450" mass="51573" checksum="08A0788CA4ACAE80" modified="2011-09-21" version="1">MDTIEAAPPPRSVEEVKAMLESTEKGGVRNSIQNCLTVFQYDPILSGAVAKNLLTERIDLLKPIGRKRRTGSKAMTDTDMKYIRLYLEKTYGLTSEKKIADAADLAADANSYHPIRDYLNGLVWDGKERVRYCLRHFLGADTDNYTFQSLRLFLLGAIHRAFCPGCKFEVMLCLVGGQGAGKSTFFRLLAVKGEWFSDDLRKLDDDNVYRKLQGHWIIEMSEMIATANAKSIEEIKSFLSRQKEVYKIPYETHPEDRLRQCVFGGTSNALDFLPLDRSGNRRFLPVMVYPEQAEVHILDDEAASRAYLEQVWAEAMTTYKSGDFKLSFTPEMIQYLKEHQRDFMPEDTKAGMIQAYLDRYTGSAVCSKQLFKEALNHPFDEPKQWEIREVNDIMNHGITGWKYFSNPRIFEGYGRQKGWEREAPATGTDNGREKTPDGFVEVTEQMELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2J8</accession>
    <name>F7K2J8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250026.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN48310">
        <property type="protein sequence ID" value="EGN48310"/>
        <property type="gene ID" value="HMPREF0994_00077"/>
    </dbReference>
    <dbReference type="GeneID" id="29725282"/>
    <dbReference type="HOGENOM" id="CLU_2752669_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="70" mass="8025" checksum="25BA0829B263DA87" modified="2011-09-21" version="1">MKWKKESLVSSMLFAIGAVIWIITIPQTYNHKGIFDILLVLHCCCALLFSAAAIAFFIKYRCSKRNKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2K4</accession>
    <name>F7K2K4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250032.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00083"/>
    <dbReference type="EnsemblBacteria" id="EGN48316">
        <property type="protein sequence ID" value="EGN48316"/>
        <property type="gene ID" value="HMPREF0994_00083"/>
    </dbReference>
    <dbReference type="GeneID" id="29723490"/>
    <dbReference type="HOGENOM" id="CLU_2193548_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="108" mass="12317" checksum="988338A278EC28D8" modified="2011-09-21" version="1">MKYELHNNLDADFPLIFGCRVLSASHPDDTYLHWHDCIEVVYCEYGQGWVISGSDRIFVEEGDIAIVNSGDIHDGFTESECRMYSLDLGSALYSPLGLEPHLFVFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2R1</accession>
    <name>F7K2R1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250089.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00140"/>
    <dbReference type="EnsemblBacteria" id="EGN42757">
        <property type="protein sequence ID" value="EGN42757"/>
        <property type="gene ID" value="HMPREF0994_00140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="283"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="391" mass="45577" checksum="925AC609A52BEA40" modified="2011-09-21" version="1">MYRVLFAEDELLVRLGLKNAIRWSDYDMEVVGEADNGITALELFEELRPDVLITDIKMGGMDGYELIKRVRDIDGSCAVVIISCLDDFETLRRMMGYCIIGYILKASMTLEEIGDVLNRTRQYLVNVRRQQNVQEENKEEKRENALRNYLCSVTGPEENIRWMSDWGLPLENLRTLIILSLREADEKKINELGMKLVRQLLCQSFPEAVCVQTGSTELTVICTVEGEAAEEQLLKFDNAVNNLLDVTFGKKKMRLSREHSVWESYQALRQEKEAVWEEDPLMEKAVRFMEDNHGKQITLQEITDYLCISTSYFSSQFKKNTGKSFVEYLNDIRLEKVLGELRYSREKIAYIAERHGFRNQEYFTRFFKKKMGISPVKWRQQHFGKDGGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K420</accession>
    <name>F7K420_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chemotaxis protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44798.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359854.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00610"/>
    <dbReference type="EnsemblBacteria" id="EGN44798">
        <property type="protein sequence ID" value="EGN44798"/>
        <property type="gene ID" value="HMPREF0994_00610"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="108"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44798.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="285" mass="31506" checksum="33AFF8D2B06EA436" modified="2013-09-18" version="2">MKKRKKNSEQGDWLNTYADMVTLLLCFFVLLYSISSVDQDKWKNFVLSINPQAAEALQEPRADGAFQEGVMDEYPEGDADAFEEMFRALIEAANQLGIENQVSITQGDGYTFISFKDKVFFDGDSPVLKEEGKTVLDAFAEAIAPAADSVKQIEVLGHTSQGDPEIPNEVMTDRVLSAERSAQIVAYLQGKDIIEPAKLVSMAFGQFRPIDTFQTSEGRAHNRRAEILITKDGTVERSLSYYYEQVYGSGTFEEGMDALKEEGGDTDAGDSADDKQEPSEGKNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K450</accession>
    <name>F7K450_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250590.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00641"/>
    <dbReference type="EnsemblBacteria" id="EGN44829">
        <property type="protein sequence ID" value="EGN44829"/>
        <property type="gene ID" value="HMPREF0994_00641"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.695"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458450_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="587" mass="68182" checksum="89B20DFCCE845784" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K453</accession>
    <name>F7K453_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250593.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00644"/>
    <dbReference type="EnsemblBacteria" id="EGN44832">
        <property type="protein sequence ID" value="EGN44832"/>
        <property type="gene ID" value="HMPREF0994_00644"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.698"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="114"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="350" mass="39805" checksum="1BA91D6AE9652392" modified="2011-09-21" version="1">MNWISKINGVFKVMGLSINAASLCTFFSVVILFFVILYGILQVLFKKKKIDSTTKSFYLFVGPWVFGFLMFTLGPMIYSFTMSFFDWELVTEPVFSGLNNYAKLLTDKHVAQSLKVTFIYTFVAVPLQVVLAFLLAALLNNKIRGINVFRTIFYLPNLISGVPQMVLFMWVFNPNFGLINSALKMLGIQGPGWFSDPAWSLPAVIIMSLWTVGGSMVIYLAGFQDISVSLYEQASIDGANGFKKFISITIPQMTPIIFFNMITAMIGAFQTFTQGYMVDGGIKDSVLFFAYYLYENAFKWFKMGYGCALAWVLFLIIMVFTLIVFRSSDMWVYYENEMMPAKKKKRKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K475</accession>
    <name>F7K475_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250615.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00666"/>
    <dbReference type="EnsemblBacteria" id="EGN44854">
        <property type="protein sequence ID" value="EGN44854"/>
        <property type="gene ID" value="HMPREF0994_00666"/>
    </dbReference>
    <dbReference type="GeneID" id="29725507"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.722"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363701" evidence="2">
        <location>
            <begin position="30"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="546" mass="61103" checksum="1E9EFEDC15B39BD8" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K487</accession>
    <name>F7K487_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00679"/>
    <dbReference type="EnsemblBacteria" id="EGN44867">
        <property type="protein sequence ID" value="EGN44867"/>
        <property type="gene ID" value="HMPREF0994_00679"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.735"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628202_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356398" evidence="2">
        <location>
            <begin position="30"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="474" mass="50642" checksum="C028D5E18707C2C9" modified="2011-09-21" version="1">MKRKSLTWMLCTAMTALLLAGCGNSTETADSGQTAQESKTAEESKGEDSEPAEPAADANAADGELPTITFVHGYYHDESEWAAAAEMRSIYQEFADAHKDEFHFVIQADETGAEGIYNTALNDISAGEFYDIADFGGWDITPVASAAGMILDLKPYLDEDSGFKDGAGVCYEQNLTDDGKIYSVREQIEGVGFWYNEALFKEAGADTPDTWKTWDDFNGAVDKLTAAGIMPFGLNAGWPTNILTAAYLQRSGDSRSFYAEGKMTESFNQPAFVDTLSFIQKNALQKIDSANFGPGGDDDEAYRSDFFAGKTAMLFNGVWDAGGSVDCEAGAENIKPAVFPTDEAGKKAALLSGGCGYVVSSQLDEAQTAAAVEFIKYMTSPEVAARIIEKGIGMAPSTAVDYDALADSVEAPEAKLLVEACRLCQNADYQALGLGNNFGDAEGEIQAKYAGLKDGSKTVESAVEELDAFLEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K488</accession>
    <name>F7K488_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250629.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00680"/>
    <dbReference type="EnsemblBacteria" id="EGN44868">
        <property type="protein sequence ID" value="EGN44868"/>
        <property type="gene ID" value="HMPREF0994_00680"/>
    </dbReference>
    <dbReference type="GeneID" id="29726158"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.737"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635706_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="439" mass="48760" checksum="5ABE7EFFAD33C9A4" modified="2011-09-21" version="1">MGERKGIYQGMLCKILLLSAAAAVLVGCGRQEEPEVTELTFIHGWGGTVKTHSTMQEIYRAFDEENPDIVLNYQPSSDSYIAVEQANNMLAIDKMPDIVSTNGQSYYVQNAVKRGMALDLLPYIEADEAFIRSIHPSVLETWTEENGGLYTVPDALEVMGYWYNAGYFREAGIVDEKGNARPPQTWEEFREAFAKLDAWGEDRVNERGEGRVDTCALENVQVAENLFLAVLAGKGSEGLQMAGALPDTFDTPVFRDAVREFSWIFSHSLSAESLDDAREYFREGKTAVYFNGIWECEEFKGCAAETDIAYANYPTESGESLSYISPSSGYVLFDSYDEKKKAASVRFLKYMLSEEVQLKLALETGQAPSNPNVDLAVIREEYPLLGNALEQAHAADIQIKTITSVWNSGIMETIGADIRRACMEEEALDSLISALDKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4N1</accession>
    <name>F7K4N1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250767.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00818"/>
    <dbReference type="EnsemblBacteria" id="EGN43527">
        <property type="protein sequence ID" value="EGN43527"/>
        <property type="gene ID" value="HMPREF0994_00818"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.893"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106729_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="152" mass="18032" checksum="4C070675A87C60EE" modified="2011-09-21" version="1">MRVTVETIDRQQEEQVLIRCHEVTDTVREIRHFILSRQESLEGYEAGKQFQIPLPEIYYAEAVDNRLFIYTKEKVYEVKMKLYAFEEAYGSKQFFRCSRTAVVNLMRIDYLRPALNGRLCARLQNGEDIIISRKYVNSLREILKRREGSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K526</accession>
    <name>F7K526_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00964"/>
    <dbReference type="EnsemblBacteria" id="EGN43273">
        <property type="protein sequence ID" value="EGN43273"/>
        <property type="gene ID" value="HMPREF0994_00964"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1053"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="171"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="32861" checksum="C573033DE242163E" modified="2011-09-21" version="1">MNHFYRLYRPATAVPHRNDSTYTEITPCSALRPYIKCFWGSVGPSAAKATAGELIIPDTCMDIIFEVNHSQNSMKSRFVGINNEAFFSAGSTEEKDTSSTFGIRFFAWSAAMFSQDSMNGVKNKVFDVQYHYEAIKTALEPILYEVTDIHARAREAEKILLRRLDSARHKPVLDAAIGALLARKGNIRTTSLADEVFLSTRQLERLFAEYTGVSPKQLSSLVRYQYLWHDILTEDSFHPANAVHKYGYTDQSHLLHDFKRYHTLLPAQAKDYALKKADILRESNTPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5V9</accession>
    <name>F7K5V9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251187.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01238"/>
    <dbReference type="EnsemblBacteria" id="EGN42485">
        <property type="protein sequence ID" value="EGN42485"/>
        <property type="gene ID" value="HMPREF0994_01238"/>
    </dbReference>
    <dbReference type="GeneID" id="29725528"/>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067323_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="29267" checksum="1D657C2886F577D0" modified="2011-09-21" version="1">MRYGCKRYGGISIVKIKKPGKWISNDMENMIQIMKKICTANTGNDFIRLEMLSSENITEEKEYHGVRTKFRAYIKNVKIPFSIDVGVDDVIVPGAVKRTVHTRLEGFHSPTIYTYSLESTIAEKFDAIVKRMEATSRMKDFFDIYYLSGVFDFEGRKLQEAISCTLDHRGTIYESNSFDRIKSFKNNTLMINLWNNYQSGTKENKPDFHVVIEQLEKFLEPIFHAVIEEKEWFYTWDSSVQKWIPCSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5Y1</accession>
    <name>F7K5Y1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01260"/>
    <dbReference type="EnsemblBacteria" id="EGN42373">
        <property type="protein sequence ID" value="EGN42373"/>
        <property type="gene ID" value="HMPREF0994_01260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1377"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="34669" checksum="C41D4FB81424FED7" modified="2011-09-21" version="1">MNSKKRNRYAYFYIAPFFIVFLIFSLFPILYSFVLSFCNMDVLSGKFTFIGVENYKRMIESGYFFQTILNTLLIWIMSIIPQLTIAFVLSLILSNKWFRGKFLLRNLYYFPNLVTPVTIGLLFGALFSYPGGAVNNIISTFGLQAVDFQNNPMLARIVIAIAICWKNFGFNIIYFTAGINSISEEVMEAAEVDGASSWQKITRITIPLMKPILIYVMVTSIIGGLQMFDESHLVFKSVPGDATWTMVKYMYESAFVRFQFGYGAAVAYGIFVIIAIFSVFSLLVTRDKKDDYGSKPKKIRKGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K689</accession>
    <name>F7K689_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42239.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359991.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01377"/>
    <dbReference type="EnsemblBacteria" id="EGN42239">
        <property type="protein sequence ID" value="EGN42239"/>
        <property type="gene ID" value="HMPREF0994_01377"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50338B0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043399_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="PTHR11927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42239.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="34996" checksum="8ED95EBE6D18EB86" modified="2013-09-18" version="2">MIIIKVMGGLGNQMQQYALYEKFKSIGKNVKLDISWFEDSSVQEKVFARRSLELRQFKDLQFDTCSAEEKEALLGKSGILGKLERKLIPARNKHFYESDIYHSEVFNMSDAYLEGHWACEKYYHDIMPLLQEKIQFPESANSQNITVKKRMKAENSVSIHIRRGDYLDPENEAMFGGICTNSYYKAAEEYIKSRVPDTHFYLFSDDTAYLRENYHGDEYTIVDWNKGEDSFYDMELMSCCRHNICANSTFSFWGARLNRTPDKIVIRPAKHKNSQEIEPQLLHELWDNWVIIDGDGRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6I5</accession>
    <name>F7K6I5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ComF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251442.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01493"/>
    <dbReference type="EnsemblBacteria" id="EGN41967">
        <property type="protein sequence ID" value="EGN41967"/>
        <property type="gene ID" value="HMPREF0994_01493"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1629"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZR_2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="148"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="27247" checksum="40CD73FAD434B30F" modified="2011-09-21" version="1">MKERCTRILAVLTDLLFPRRCPVCDRPVEPSGAYICGACRKKLIFIKEPRCLKCGKQLREKEKEYCYDCGGKTHIYDRGIALYTYGSIRPALYRLKYGGRREYGEFLGRELAMRLGREILSWRPDGLVPVPLHPAREKKRGYNQAALLAEEMGKCLNIPVFSGLVERSRNTCPQKELDGAARQINLKKAFKIAQNDVKLNTIVIIDDIYTTGSTIDAVAEVCRNAGIKHVYFVALAIGRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6L8</accession>
    <name>F7K6L8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251477.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01528"/>
    <dbReference type="EnsemblBacteria" id="EGN42002">
        <property type="protein sequence ID" value="EGN42002"/>
        <property type="gene ID" value="HMPREF0994_01528"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1666"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="5"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="389" mass="41888" checksum="5E9C1113174D3AB5" modified="2011-09-21" version="1">MMTLLLIIIYISFISLGLPDSLLGSAWPVMYGELQVPVSFAGIISMIIAGGTIISSFFSEKIIRRLGTGPVTAISVFMTAAALLGFSLSHSAWLLCVLAVPYGLGAGSVDAALNNFVALHYKAHHMSWLHCFWGIGATAGPFIMSLCLNTGKSWHSGYMTIALIQIILTVFLFLSLPLWKKQQAGTATEENGAQNTSLSFSRVLQLPGAKPALLCFFGYCALEASAGLWGSSYFVLAKGIPAEKAAQWTSLFYFGITFGRFISGFLSMKVSDKNMVRLGQAVALIGILVLCLPFGPLSICGGYFLIGLGCAPIYPSLLHATPANFGREYSQAIMGIQMACAYVGSTFMPPLFGLIAQYVNIRLFPCFLLLFVILMVITAEKLKIKSEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Q6</accession>
    <name>F7K6Q6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01566"/>
    <dbReference type="EnsemblBacteria" id="EGN42040">
        <property type="protein sequence ID" value="EGN42040"/>
        <property type="gene ID" value="HMPREF0994_01566"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1711"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104072_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="164" mass="18250" checksum="66DF6CEB42A348AF" modified="2011-09-21" version="1">MDITLSEDIDPEYLEDVSDILTNREFLALNCFKHHYATTRLMHSMNVSYISWLLAKKLGCDAKAAARAGLLHDFFLYDPKQGRPSRELQAFCHPKVAAANSKATFDITEKEKEAILSHMFPLGPLPKTQEAWIITGADKLCACVEVFHIGIALTRSGRVVVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6W2</accession>
    <name>F7K6W2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42103.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002304353.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01629"/>
    <dbReference type="EnsemblBacteria" id="EGN42103">
        <property type="protein sequence ID" value="EGN42103"/>
        <property type="gene ID" value="HMPREF0994_01629"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032T16">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189835_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42103.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="62" mass="7516" checksum="AE703DD1BBD85FB5" modified="2013-09-18" version="2">MPRMSKKRKHELSFYLNDRGRVTYNELCRKCQHGCKQSFRAVVIDCPRYLSKRAKKKEEHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Y3</accession>
    <name>F7K6Y3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251563.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01650"/>
    <dbReference type="EnsemblBacteria" id="EGN42124">
        <property type="protein sequence ID" value="EGN42124"/>
        <property type="gene ID" value="HMPREF0994_01650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1802"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="175" mass="18466" checksum="B7AE593D039F026A" modified="2011-09-21" version="1">METMKAIAKRKSTRAFNPEKGIAKADLDAILAAGCAAPVGAGDYSSLHLTIIQSKEMLDKINKAVQAAFKTDRDVLYGAPVLVLVSSSEPKFPNIQYANVGCVMENMLLAATDRGVDNIYLWGAANAVAQMPELRKELGIPEGFTPISGAALGYAAESSSAEKELGITLAANYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7K0</accession>
    <name>F7K7K0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251742.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01829"/>
    <dbReference type="EnsemblBacteria" id="EGN41642">
        <property type="protein sequence ID" value="EGN41642"/>
        <property type="gene ID" value="HMPREF0994_01829"/>
    </dbReference>
    <dbReference type="GeneID" id="29727647"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2001"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1045050_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="266" mass="30817" checksum="BD2887BAEFF22C81" modified="2011-09-21" version="1">MRQLLRIGQVCKLYGISLDTLRHYDKIGLLKPLVTEPSGYRYYSFEQLDILEMILAGRSLDIPLENLQKRLASGEIEDYILLVKEQQTVIEERKRELQQLENHSLQMAELLTQISLHKNDEDLQNIHYVALDMDICRIPIAMFPPARFDGNDMGSFLQMEQWSFYQSDSNGFVAELPQDAGLSCRNAERMGEMFPESTGAKIVKIKGIYGETKFLGKSSSLHIYLNKISKSFHLQNTELLVKYIFALPHEDLDNNYFVEIYFPKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7S9</accession>
    <name>F7K7S9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIGR02954 family RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251887.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01974"/>
    <dbReference type="EnsemblBacteria" id="EGN41379">
        <property type="protein sequence ID" value="EGN41379"/>
        <property type="gene ID" value="HMPREF0994_01974"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2169"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="19039" checksum="57A73ECF4CF9E765" modified="2011-09-21" version="1">MSQHLTKKQFAQYMENGKAKFYRLAFCYVKNEHDALEIISEATYRGFIHLNKLEKPEFFDTWMSRIIINCAYDLLKKQKKYEFVVPDDSLSEPPDAVSIDERIDLYQALNTLHPEEKTLIILKYFEDRSFREIAETMKLPESTVKTRLYRTIGKLKEAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K827</accession>
    <name>F7K827_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251987.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02074"/>
    <dbReference type="EnsemblBacteria" id="EGN41479">
        <property type="protein sequence ID" value="EGN41479"/>
        <property type="gene ID" value="HMPREF0994_02074"/>
    </dbReference>
    <dbReference type="GeneID" id="29727867"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1862065_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="154" mass="18168" checksum="C5EFA66F442D1462" modified="2011-09-21" version="1">MFFTNRRKKVPGSQTKQSRQNSIKKSIPFYIMFIPVLIYFVVFRYVPLLLSLVISVEKYQPAKGIFQSKWVGLEYYKQFIDSVFFWRLIRNTLGINFLQLTIGFAAPIILALLLNEVGRVRYKKLVQTVTYLPNFISSLNCNARFHTQDLEWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7K893</accession>
    <name>F7K893_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_01866</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01866"/>
    <dbReference type="EnsemblBacteria" id="EGN41271">
        <property type="protein sequence ID" value="EGN41271"/>
        <property type="gene ID" value="HMPREF0994_01866"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2045"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261735_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="12">
        <location>
            <begin position="607"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="942"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN41271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1314" mass="148792" checksum="3A8E1FBA196E1CF2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8F0</accession>
    <name>F7K8F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252043.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02130"/>
    <dbReference type="EnsemblBacteria" id="EGN41037">
        <property type="protein sequence ID" value="EGN41037"/>
        <property type="gene ID" value="HMPREF0994_02130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2333"/>
    <dbReference type="eggNOG" id="ENOG5032WQX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033607_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="28858" checksum="147A5A2C98A102E0" modified="2011-09-21" version="1">MDIKKIVFIIGGIDIVLLGISLFLYLGKDRTAPVITFAENLVSYEEGMDEALLLEGVTAMDAKDGDVSGSLLVEKIAGTTGKEVIVTYVARDSANNVGKASRAFPVAGTYNDGDVLPVMGGVMEGESGTEEGSVTESETETKTETMSGEESSSAEDDEGRDEADAESDRREEARQEEPAEEPEPSAGPNPVLVMSGDVVSTKVGTPPNWSQVIAAMSDDKDDYNTLYKNLKLDGHVKLDEVGEYSVTLYTVDTDGNRSEVRDLVVRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8G0</accession>
    <name>F7K8G0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252053.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02140"/>
    <dbReference type="EnsemblBacteria" id="EGN41047">
        <property type="protein sequence ID" value="EGN41047"/>
        <property type="gene ID" value="HMPREF0994_02140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2341"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="28667" checksum="D13DE29C3B4F932D" modified="2011-09-21" version="1">MNNNLTLFTASPDISVRDALKMIDENKKGFLIIADDNDAVLGTLTDGDVRRAFLKGASVDDGIEGLYTRNSKFLKQSDGIPKATEMFKSESIKFLPIVDEETRLLNIITKNQMHALLLQDIHADLEYDFMSLDEGIVDYEIFQRPWGFYKTTVMNDYFQFKIISVNPKSQLSLQSHNHREEHWIVAHGVGTVQIDQSIIDVHCGSSVFIPKGAKHRLTNKGDKESLIVTEVQIGDYFGEDDIIRYEDIYGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8U9</accession>
    <name>F7K8U9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4037 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252209.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02308"/>
    <dbReference type="EnsemblBacteria" id="EGN41215">
        <property type="protein sequence ID" value="EGN41215"/>
        <property type="gene ID" value="HMPREF0994_02308"/>
    </dbReference>
    <dbReference type="GeneID" id="29726748"/>
    <dbReference type="HOGENOM" id="CLU_2601513_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025117">
        <property type="entry name" value="DUF4037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13228">
        <property type="entry name" value="DUF4037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4037" evidence="1">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="79" mass="9173" checksum="019DD2461C3FF5EF" modified="2011-09-21" version="1">MAGVARLSTMRIINVLVDKTGVLEAMKEELTEYPERLRKAVLDASYPYIWDEENVGRAVLRKDIVFNHHVFQHSLDLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8V0</accession>
    <name>F7K8V0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41216.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359779.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02309"/>
    <dbReference type="EnsemblBacteria" id="EGN41216">
        <property type="protein sequence ID" value="EGN41216"/>
        <property type="gene ID" value="HMPREF0994_02309"/>
    </dbReference>
    <dbReference type="GeneID" id="29725275"/>
    <dbReference type="HOGENOM" id="CLU_791769_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41216.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="350" mass="41171" checksum="CF8CEAAE9E686582" modified="2013-09-18" version="2">MKKGIYDVGGEKLSNSAFLKAKEFIYRYGRKIDIAWFEYNFVNNSTDEFMKVLKKYQFENGGFGGLVTEFEYSGPCLKSTEHAFRYIYNLKEKPDSGSPIIQNMMKYVLERYKPEMGCWGNLLVPEVNEMLHVWWWEYKKCDIEYLDFDSKVKAYNPNGQAALAAFTALYSDLIPLEKYQEIISCPVEKVLRYFDKNSPFYCEVSSDPSFKEDYMVPYNMKCYQQFIDCLQSDSNRYRDQELVERLKQILSRDPSVCMELDESLWTEGYHEIPCDIVTRPDSFLYPLVRSEVDSALDYLIRHQSEDGAWHLSYQFGEQEGFRKLERQYEANITALYLAELKSFGRIVGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8W2</accession>
    <name>F7K8W2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbamoyl-phosphate synthase pyrimidine-specific large chain</fullName>
            <ecNumber evidence="6">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HMPREF0994_02325</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252226.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02325"/>
    <dbReference type="EnsemblBacteria" id="EGN41232">
        <property type="protein sequence ID" value="EGN41232"/>
        <property type="gene ID" value="HMPREF0994_02325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2541"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="672"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="19">
        <location>
            <begin position="933"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGN41232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1074" mass="117713" checksum="38F7CEC855FDDC74" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K968</accession>
    <name>F7K968_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="7" type="ORF">HMPREF0994_02411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252312.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02411"/>
    <dbReference type="EnsemblBacteria" id="EGN40810">
        <property type="protein sequence ID" value="EGN40810"/>
        <property type="gene ID" value="HMPREF0994_02411"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2641"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="157" mass="17279" checksum="A05DFFB128451948" modified="2011-09-21" version="1">MDVKIFTDGAARGNPEGPGGYGAILQYVDQKGMLHEKELSGGYVKTTNNRMELMAVIAGLEALNRPCRVEVISDSKYVTDAFNKHWIDGWLKKNWKGASGPVKNVDLWKRLLKAAEQHKITFTWVKGHDGHPENERCDVLATSAADGDGLLVDPGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K977</accession>
    <name>F7K977_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dUTP diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252322.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02421"/>
    <dbReference type="EnsemblBacteria" id="EGN40820">
        <property type="protein sequence ID" value="EGN40820"/>
        <property type="gene ID" value="HMPREF0994_02421"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2653"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="172" mass="19276" checksum="ABB9610C1F8ED5BE" modified="2011-09-21" version="1">MRRIARFMKVSREQFLSDFKDSFPEYGEEQIVKIYEELKLPARATSGSAGYDFFTPVALELKPGETIKIPTGIRASMQPEWVLHLYPRSGLGFKFRLQLNNTVGIIDSDYFNSDNEGHIFAKITNDSNEGKVLTLQAGEGFMQGIFLEYGITEDDDADGVRNGGFGSTTQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9L2</accession>
    <name>F7K9L2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252483.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02582"/>
    <dbReference type="EnsemblBacteria" id="EGN40981">
        <property type="protein sequence ID" value="EGN40981"/>
        <property type="gene ID" value="HMPREF0994_02582"/>
    </dbReference>
    <dbReference type="GeneID" id="29723522"/>
    <dbReference type="eggNOG" id="COG4332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090982_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009412">
        <property type="entry name" value="DUF1062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06353">
        <property type="entry name" value="DUF1062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="220" mass="25347" checksum="6F4A832B919473E4" modified="2011-09-21" version="1">MSYIKKEEWTILPGEAPAIRRNCSGCRKSSIFRSSGNFRMNANGNKLDVWLIYRCEKCDTSWNMDIYTRVAPGTLGQDLYNRFLENDSDTALDFGCRKEILSRNKAEALWEQVPFKVEKTFHEAKDASETLDYAERMISAENTVPVERIVSVERIVSIHNPYEIPMRLDKLLCRELNCSRKDVACLEDSGGLYIRTGGKDSRSRIPIYMEAEIREPFPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9W4</accession>
    <name>F7K9W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252548.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02647"/>
    <dbReference type="EnsemblBacteria" id="EGN40630">
        <property type="protein sequence ID" value="EGN40630"/>
        <property type="gene ID" value="HMPREF0994_02647"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2901"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="16667" checksum="A17A875C341D7F1B" modified="2011-09-21" version="1">MVIGYTAGVYDLFHVGHLNLLKNAKGMCDKLVVGITTDELVTYKGKHSMIPYEDRMEIVRSIKYVDAVVPQSNMDKLTMCKKLGASILFVGDEWYGTEKWKNYEKEFSESGVQIIYFPYTKGVSSTLITQTLLQVRDNPETSIKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9X8</accession>
    <name>F7K9X8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40644">
        <property type="protein sequence ID" value="EGN40644"/>
        <property type="gene ID" value="HMPREF0994_02661"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3404124_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="30" mass="3620" checksum="EFE86D62F6593922" modified="2011-09-21" version="1">MMLFLIFSGKVQTDLNRYYFLTKKENANSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAM6</accession>
    <name>F7KAM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252753.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02852"/>
    <dbReference type="EnsemblBacteria" id="EGN40461">
        <property type="protein sequence ID" value="EGN40461"/>
        <property type="gene ID" value="HMPREF0994_02852"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3120"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="24445" checksum="656EAA5BDD28FD22" modified="2011-09-21" version="1">MNTIITIGRQFGSGGREIGEKVAEYFGIKCLDKELLTRAAKESGFCEEMIKNHDERPTNSFLYNLVMDTYSFGYNASSFMDMPISHKVFLAQFDTIKKVAEEGPCIIVGRCADYALHDFKNCINLFIYGDEEVKIKRIMRKYNLTEDKAREMITKKDKQRQSYYNYYSSKKWGRADSYDFCLNSSVLGVDGTVKLIVQMVEDFEALNGVTPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAP5</accession>
    <name>F7KAP5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252772.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02871"/>
    <dbReference type="EnsemblBacteria" id="EGN40480">
        <property type="protein sequence ID" value="EGN40480"/>
        <property type="gene ID" value="HMPREF0994_02871"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3140"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="298" mass="32923" checksum="49B58AC2890F9372" modified="2011-09-21" version="1">MSPVIKKKRNKFTLPSKYLLLILSGVCVALMLVTFKTDLFEGPLRAAAGYVVVPFQKGIASVGGYLYDRAEEMGQLKEVLAENQALKDQVDALTMENAQLQQDKYELTSLRELYEIDKATSEYEKTGARVIASDSSNWFYSFVIDKGSDDGIQVDMNVLAGSGLAGRVVSVGPNYARVVSIIADNANVYGTILSTSENLMVSGDLQSVMSDGVIRFEQLYDKENKVSEGDKVVTSNISNKYLPGIPIGFISSISTSYNNMTKYGYITPAVDFQHIQEVLVIMELKQQVTQEKHSMDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAR3</accession>
    <name>F7KAR3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate 5-kinase</fullName>
            <ecNumber evidence="7">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-glutamyl kinase</fullName>
            <shortName evidence="7">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proB</name>
        <name evidence="9" type="ORF">HMPREF0994_02889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252790.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02889"/>
    <dbReference type="EnsemblBacteria" id="EGN40498">
        <property type="protein sequence ID" value="EGN40498"/>
        <property type="gene ID" value="HMPREF0994_02889"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3158"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_0_2_9"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="291" mass="32377" checksum="EFFDF76457EA33B3" modified="2011-09-21" version="1">MEQYREKLKDKKRIVVKIGSSSLQHPETGELDYIKLEVLVRELCNLKNQGKEVVLVTSGAIAQGKKAMNLKEEDITEHNRIAMKQACAAIGQSRLMMTYQRIFSEYNQVTAQILMTKNTIVDNLNRYNAHNTFSQLLQMGVIPVVNENDTVATYELEMDNDTLSAIVAALIGADLLILLSDIDGLYTDDPRKNPEAKFVEIVEELNDTYMDMGKGSTGSNVGTGGMNTKLTAAKIATKAGADMLIANSRDIRIIHRLMDGRNYGTLFVAKRDENFDLPGFVSKLNKSNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAU4</accession>
    <name>F7KAU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40351.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40351">
        <property type="protein sequence ID" value="EGN40351"/>
        <property type="gene ID" value="HMPREF0994_02973"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2046632_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40351.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="120" mass="14154" checksum="F1E5BFF912A23523" modified="2013-09-18" version="2">MAGIFPENRKQYWQPGTTGVESRLHQSREQGEFNNTYNRRFMKEEVPYSGFESYFYNTAQDAGEMNGDFDADGHILKEECSVDFDSSAREEAQLNIFDNSQRNIQKLFREIQDKIQLFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAV6</accession>
    <name>F7KAV6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252886.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02985"/>
    <dbReference type="EnsemblBacteria" id="EGN40305">
        <property type="protein sequence ID" value="EGN40305"/>
        <property type="gene ID" value="HMPREF0994_02985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3261"/>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="76"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="395" mass="41989" checksum="B39E71D4E6227E6A" modified="2011-09-21" version="1">MKKQHKRPDKFRKSRLHPQLPLRAVLSFFLCAFLLSASGCTGIQPSGSGSVSSGDEGNTLQDISGTVKVHFIDVGQGDSILIQSGKECMLVDAGTNETGTEVVRYLKSLGISRLAYLIGTHPHEDHIGGLDDVIHSFDIGTVIMPDVSHTTRTYEDVLDALIDKDLKVTKPVPGTVYQLGEASFTILSPTEEVEQQAAAAGDLNNLSVGLRLTFGANAFVMCGDAETLSEEAIVESGLTLKADVLKLGHHGSSTSTCDSFLQAVSPSIAVVSCGKDNSYGHPHRETMDKLAAEGITVYRTDEQGTLTATSDGSVITWNTGSGASADTGILSDESASEGKTIADSNSYVLNKNSMKFHLPDCSSVEKMKESNKIYFGGSRDEVIGMGYAPCSQCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBC2</accession>
    <name>F7KBC2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253052.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03151"/>
    <dbReference type="EnsemblBacteria" id="EGN39981">
        <property type="protein sequence ID" value="EGN39981"/>
        <property type="gene ID" value="HMPREF0994_03151"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3443"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031875_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="444" mass="52800" checksum="7106876D312AFA58" modified="2011-09-21" version="1">MDFVKVKGKEFYYKGEPILFSGLGVGSWLNMEHFMLGLPGTDAQIRKTFEEVLGKEDGEKFFESFILNFLTDEDFRFLKETGVNLLRVPFSYRLFIDDLNPHTYREEGFRYMDRLLALCTKYEIFLMPDLHTTPGGQNPDWHSDNMTGVPQFWHFRIFQEQIVKLWKAIAARYKEEPFLLGYDLLNEPFLMPKKEGLLNAFLEEVTTAVREVDPNHIIFIEGDFFSMDFTDIRLPRDEQTALTFHFYPTVWDENLTNKDYDAAERVRKMDEQLSGFAALRDTFGRPALCGEAGVDIKKDDLPFTMQLLDETLSLFQKHSLSWTLWSYKDAQWMGLAYPGNDTGWMKLVSEIRKKWSHYGQMQIADEFMDEIGKRYTDDFSKELKYELQFQLRGVLYRMEEEYILKPVLEKYSREEIMAMPESFRFENCDYYEEYRELLKQYSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBD0</accession>
    <name>F7KBD0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Osmoprotectant transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253062.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03161"/>
    <dbReference type="EnsemblBacteria" id="EGN39991">
        <property type="protein sequence ID" value="EGN39991"/>
        <property type="gene ID" value="HMPREF0994_03161"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3453"/>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038355_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="2">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="32743" checksum="CFA883A0BB365E1F" modified="2011-09-21" version="1">MKRKLALFLTAALAIGTLAGCGKEKEPIKIASKPMTEQYVLTEILGQLIENDLGVPVEITKGIGGGTTNIQPALLKGDFDLYPEYTGTSWMTVLKHEKEDDSDVLYENLQKEYNDMGLTWSGLYGFQNSYVLAVRKEAADTYGLETFSDLAAASENLIFGGNPDYMEREDGYPMICEAYGMNFKGTVDVDIALKYQAMANKEIDVTNAFTTDAQLAAADVKLLQDDKSLFATYYAGTVVRTDTLDKYPGLADTLEKLTGQISDDEMRNMNYQVEVEGKDEKEVAKAFLIEKGLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCH7</accession>
    <name>F7KCH7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltose/maltodextrin transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253460.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03559"/>
    <dbReference type="EnsemblBacteria" id="EGN39468">
        <property type="protein sequence ID" value="EGN39468"/>
        <property type="gene ID" value="HMPREF0994_03559"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3889"/>
    <dbReference type="eggNOG" id="COG3833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="30781" checksum="84F04AB9B65C330D" modified="2011-09-21" version="1">MKRSAKRTLGLAALNLFFISICLIGLVPILYAFLLSVSSGSGALTTGLSILPEKYTLDNYRTILVEKPFLKWLSNSVVLSVGTMVLAMGTSVTASYAFSRFRFPGRAAAMQILLLLNAFPQILSMFAIFRLFKLLNLLNSHAGLIFIYSGSMCIFSIWNMKGYFDSIPIEIEEASKIDGAGNLTLIAKIILPLARPAIIVTAVMVLIFVWNEYLFATTFMLREESYTLAGGLYQLQANDYSRSWPLFSAAAILVSVPILIIFFCIQKYMVSGLTAGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCI7</accession>
    <name>F7KCI7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-L-AF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253472.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03571"/>
    <dbReference type="EnsemblBacteria" id="EGN39480">
        <property type="protein sequence ID" value="EGN39480"/>
        <property type="gene ID" value="HMPREF0994_03571"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3902"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="289"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="504" mass="56953" checksum="73D21937C9D0C116" modified="2011-09-21" version="1">MKANITIDSCKKAGEIDRKIFGHFMEHAFGNIYGGVYDPESRFADEDGFRTDVIELLKEVKVPVLRYPGGNFVSSYHWEDGIGPKENRPKKFDFAWGASESNQFGTADFIKLCRKTGAEPLICVNMGSGTAEEAMNWVEYCNGTQDTYYANLRRSHGYEEPFHVKYWGLGNEMYGVWQMESMTAEEYAGSAAQFAKAMKKVDESIHLVACGMEQDAEWNHTVVKKLEPYIDMISAHYYGMGWEEFGDISEQYEQTLYIPYQMEERHKLTLASIITGQNGIKDNIKVAWDEWNMFGWSFDAVNEDSTYNLHDAIITALILNMILRNCDTIKMAMYSTFVNITGALSVTKEGCLKRTQYHVFDMLSNHTGSHLIRTDVDCSSSITIHDIGHLSFGANIDNKNNHASGKIVDKDIPAIDAVATMDSKNIYVSVVNQSLNEDCELFLDIHAQNIGSTMEKTELYGDSILDANTFDDPDHICPHKSTQDVNQPVIIRKHSVNVITIPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCU5</accession>
    <name>F7KCU5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253575.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03674"/>
    <dbReference type="EnsemblBacteria" id="EGN39046">
        <property type="protein sequence ID" value="EGN39046"/>
        <property type="gene ID" value="HMPREF0994_03674"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN39046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="223" mass="25972" checksum="328F8A1AD33962BB" modified="2011-09-21" version="1">MFTILVVEDDRELRELFCTVLTENGYRPLEAGDGEEALKVMETEYVDLIISDIMMPHMDGYELTKEIRRANMNLPILMITAKDSSFYKKEGFQAGTDDYMVKPVDVNEMIWRIKALLRRSQAAHERKLTVGTTLLYCDSYCVKREDEEIILPPKEFQLLYKLLATPNRTFTRMQLMDEIWGLESNATTHTLEVHIGRLRERFRNNPDFQLVTVHGLGYKAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD66</accession>
    <name>F7KD66_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253696.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03795"/>
    <dbReference type="EnsemblBacteria" id="EGN38766">
        <property type="protein sequence ID" value="EGN38766"/>
        <property type="gene ID" value="HMPREF0994_03795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4134"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="15"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN38766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="394" mass="42515" checksum="DC9155D67FD71B97" modified="2011-09-21" version="1">MRKEQQYKAKLFTTGYLFLILISLTTAMSYSMISTLITNYAVKLGGTLAMAGTIAGIFSMAALFSRPVGGLICDTLNKKKICIIATVVFCFSFLGYAFSANMAVMLFFRIIQGFSFGISGTANMALVAEIIPKERLGEGLGYFGLGQVVSQVIGPVIGVAMKEHMGFRALFYTVAVISAFAVVLLFLFPYDSSCHDSSKTEKRNKSYFSFRYLVAWECLFYALTAGMFSMTNGITSSFLVLLGDERGIVNIALFFTVNAACLFLVRIIMGRMADRSSILMIVGVSLAVSLSSMLLLSKAMILQTVLVAALLKAIGQGGGQISLQSACIKSVDESRIGVASSTYYIGADIGNALGPVIGGCISGIWGYEVMFQTIAVLMGGMLILFVIYQKRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD73</accession>
    <name>F7KD73_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IU_nuc_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253703.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03802"/>
    <dbReference type="EnsemblBacteria" id="EGN38773">
        <property type="protein sequence ID" value="EGN38773"/>
        <property type="gene ID" value="HMPREF0994_03802"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4141"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078738_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="15"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN38773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="32867" checksum="E17BEA8F60328A08" modified="2011-09-21" version="1">MKLTYCVPENKKIRVIIDSDTACEADDPFAIAHALMSPKLIVRAVIAEHFAAAGSMQKSYEAIKRLTAAMELDVNVLSGEEWPLKQTKRISEGVKFIIEEARSQNSHPLYILCLGALSNIARALEEAPDIEQRITVVSIGGRSYEDSMRDFREFNFGNDVEAVNKVLESQVSFWQIPVSAYATIQVGLAELQNKVSCCGQAGKYLYEQMVTFNRSEYASWASGESWSLGDSPAVAVTINPGCGEYKDIQSKRVNPDTSYTDNGKGRLIRVYETIDSRYVLEDFFSKLELNYKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDG1</accession>
    <name>F7KDG1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253795.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03894"/>
    <dbReference type="EnsemblBacteria" id="EGN38659">
        <property type="protein sequence ID" value="EGN38659"/>
        <property type="gene ID" value="HMPREF0994_03894"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4238"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="189" mass="21815" checksum="CBE05222326ABBDB" modified="2011-09-21" version="1">MNKGQSHPASALSKNLLSKGLLSLLEEKPFRDITVKELCVRSDIARRTFYRHFHTVEDVMDYVLSHIITRFREQMLLTQKETYPSILASYFAFWKNYASLLELLNKNNITYLLFGRYLECLSSLPWLFPSEDSLTEDRDSFACRLAYHSGGLWSVLTYWSMNGCRIPEDTLAQILCSQMPGAPSGRNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDH2</accession>
    <name>F7KDH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253810.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03909"/>
    <dbReference type="EnsemblBacteria" id="EGN38674">
        <property type="protein sequence ID" value="EGN38674"/>
        <property type="gene ID" value="HMPREF0994_03909"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4253"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="4">
        <location>
            <begin position="358"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="451"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="568" mass="66540" checksum="95A48691C0D9CB97" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDP7</accession>
    <name>F7KDP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03986"/>
    <dbReference type="EnsemblBacteria" id="EGN38486">
        <property type="protein sequence ID" value="EGN38486"/>
        <property type="gene ID" value="HMPREF0994_03986"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4343"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1701159_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="140" mass="16275" checksum="E04F0BEF021F93D5" modified="2011-09-21" version="1">MAYGTGGCVRKRTKKINKMLEEKNPATKNSIHHEDLALKTAAQYFGEELMPLFGIQGVADYIAPTETVMLEARQMYQYFNYVRKDGVWIHLEFESDSITKEDLKRFREYEASTSRVHHVEVITYVICSSKVKHPRTILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDU3</accession>
    <name>F7KDU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04022"/>
    <dbReference type="EnsemblBacteria" id="EGN37711">
        <property type="protein sequence ID" value="EGN37711"/>
        <property type="gene ID" value="HMPREF0994_04022"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4383"/>
    <dbReference type="HOGENOM" id="CLU_201674_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="50" mass="5295" checksum="AF2D82BC9D342861" modified="2011-09-21" version="1">MDEKIYRTMRGTGVTNIVLGIVTMVTGIVGGVLLIISGAKLLAGKSRIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE23</accession>
    <name>F7KE23_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254003.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04102"/>
    <dbReference type="EnsemblBacteria" id="EGN36895">
        <property type="protein sequence ID" value="EGN36895"/>
        <property type="gene ID" value="HMPREF0994_04102"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4474"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN36895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="244" mass="27810" checksum="2EB2AB0F11983E50" modified="2011-09-21" version="1">MDDRIAILRRILDESSYTVALCGSGMMEEGGFVGVKYADKAYDIEKKYGHSPEEIFTSAFYHTRPKQFFDFYKEEMIINAPEPTDSGRVLAAMEQAGKLQCVISSNIYELSQRAGCKNVIDLHGSIYHNYCLRCGREYSVEYIKHVKGIPACEKCGIPIRPGLFFFGEMTDPHLISQASQAIHDAQVLLLLGTTLNSEVFAHYLKYFHGKWLIMIHKERHFLDDNADMVFIDQPKNILSQLGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE27</accession>
    <name>F7KE27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254007.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04106"/>
    <dbReference type="EnsemblBacteria" id="EGN36899">
        <property type="protein sequence ID" value="EGN36899"/>
        <property type="gene ID" value="HMPREF0994_04106"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4479"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="176" mass="20546" checksum="4961657C85A39345" modified="2011-09-21" version="1">MMPERLASRTIYESDWISLYEDKVKMPDGSIIDSYHRLHFPHESVCVVICNDKDEILMIQSKRYITGQLEWEIPAGRIEDGESPEEAARRECMEETGCELEELVYLCSENPNNGMSDLLIHIYGAKVKSEEKLFDENEVNCKKWKKRGDIMYMLKNKEIHCGVSMLALLYAFSFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEJ7</accession>
    <name>F7KEJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254151.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04250"/>
    <dbReference type="EnsemblBacteria" id="EGN36530">
        <property type="protein sequence ID" value="EGN36530"/>
        <property type="gene ID" value="HMPREF0994_04250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4643"/>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="188" mass="21701" checksum="4401086FC3CC11A0" modified="2011-09-21" version="1">MEMFDIRTPEGEPTGEVKERSAVHRDGDWHGTAHIWLVRRKNGKIEVLLQKRSRLKETFPGCYDASCAGHLSAGDSFIQGALRELQEELGLEAKEEDLFLGGIYPCQVDEWFGGIHILDREISAVYLYDKPVKEEELKLQEEEVEGVCWIEFERLKELAAAGTPEYCIFPWETDALEDAFRKRYRYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEM7</accession>
    <name>F7KEM7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254207.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04306"/>
    <dbReference type="EnsemblBacteria" id="EGN36118">
        <property type="protein sequence ID" value="EGN36118"/>
        <property type="gene ID" value="HMPREF0994_04306"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4701"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="103" mass="11371" checksum="35252D68B025912A" modified="2011-09-21" version="1">MSVTNITAENFNTEVLESEKPVLLDFWAPWCGPCRMFSSTVDSVAEERNDIKVGKINIDENIDLANQFGVASIPTLVLVQDGRKKASSIGLRSKKDVLKMLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KER1</accession>
    <name>F7KER1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254241.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04340"/>
    <dbReference type="EnsemblBacteria" id="EGN35650">
        <property type="protein sequence ID" value="EGN35650"/>
        <property type="gene ID" value="HMPREF0994_04340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4738"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="227" mass="25650" checksum="A5AD8D9825F8BC02" modified="2011-09-21" version="1">MFPYVLFDLDGTLTDPKPGITQCVQYALHCMGIEEPDLDKLEPFIGPPLTDSFREFYGMDQEQAAEAVAKYRERFSEKGLYENEIYSGMKQMLEKLKTAGCHLAVASSKPEHFVKKILVYFDIDGYFEVIVGSELDGTRSQKEEVVAEALRRFFPDGNIPCDDIVMVGDRKFDIIGGREMGLHQIGVTYGYAPEGELEAAEAEYIVHDLDELERVLIWQGNQNAGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF16</accession>
    <name>F7KF16_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35767.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04457"/>
    <dbReference type="EnsemblBacteria" id="EGN35767">
        <property type="protein sequence ID" value="EGN35767"/>
        <property type="gene ID" value="HMPREF0994_04457"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="243"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35767.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="346" mass="41223" checksum="42D79924C75AD297" modified="2013-09-18" version="2">MKLSDELGKEEQLYKSLYQQCCGLWEKPVTDWNELVHRYHKAGIRKIPSEPPSRMGTVLTESDFFTENVKEVVCFNNLRYCPPFLHKLEFIKIVYIFRGSVTLYLDDEKYELQTGNFCIITPGVRHTVFSRHDEDVIINILMRVSSFANAFSGILMEQNILSDFFWKILYTKHSNRVLVFVCSNDAKLDRWVEKMFDESARQQNASNLLMKSYAMIFLGIVMREHLKELHLKEELTEEVYVLPAIIRFMRKNMKTITLDELSLQFHMSESELKRYIVRESGYTYRYLLRDLRLRRAVELLRNTKLSMERIMEETGYSNMNNFYRSFKEHLGKTPSEFRKSREEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF51</accession>
    <name>F7KF51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactose/L-arabinose transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254394.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04493"/>
    <dbReference type="EnsemblBacteria" id="EGN35803">
        <property type="protein sequence ID" value="EGN35803"/>
        <property type="gene ID" value="HMPREF0994_04493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="30816" checksum="4E369038AF60BDA9" modified="2011-09-21" version="1">MKKIKIPVILSYMVLILCVIVALFPYLWTFLAATHTNSQVFNFAYSFRLGTNIVQNYKDLLEVLPIWNNLFSSIFVAAIFTILVLIIDAMAGYGFAQYQFKGRDTLFMICLAAMMIPVQVLMVPLYIQFSGMNMIDSYWSVILSGLPGAFGVFLMRQSMLSYPRELIEAARIDGAGESRIFFTIVLPNMKPALTSLGILSFVNQWGNYYVPLVLLNSTKKYTVPVAMALLAQPNFDVNYGALMLGACMAVLPIMIFFLIFQKNFIDGMMVGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFC5</accession>
    <name>F7KFC5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254455.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04554"/>
    <dbReference type="EnsemblBacteria" id="EGN35323">
        <property type="protein sequence ID" value="EGN35323"/>
        <property type="gene ID" value="HMPREF0994_04554"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4971"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="357" mass="39736" checksum="CF305BF1810083C3" modified="2011-09-21" version="1">MKGIEIKSFGNTWDGRKALCWTITNGSGAQLSLTDFGARITGICVPDRDGRMEDVVLGFDTAEEFTQKGRYFGTTVGRYANRLAGASFRLNGSVYKLYANKGTNSLHGGKSGFDDKIWKADITGEDSIRFTYESADGEEGYPGKMDVTVCYRFTEENEVEITYRAVSDKDTIINLTNHAFYNLKGHGNGSILGHKLKLYSSFFTPVNADMVPDGSILPVKGTVMDFTGMRSIGEQIDKTDEQLRLAEGYDHNYILQKEERGSLSKAAEVVEPESGRTMTVFTDQPGIQFYSGNLMKPCTGKGGREYGKRDAFCLEAQCFPNSMEVTHFPTPVLRANDTYEQKTVYRFGICRDKEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFC8</accession>
    <name>F7KFC8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254458.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04557"/>
    <dbReference type="EnsemblBacteria" id="EGN35326">
        <property type="protein sequence ID" value="EGN35326"/>
        <property type="gene ID" value="HMPREF0994_04557"/>
    </dbReference>
    <dbReference type="GeneID" id="29727008"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="290" mass="33001" checksum="2642960197562D71" modified="2011-09-21" version="1">MYQVLDVRLLKIPGTVEELAPLAREYGFDGLDVPEAILGDEKKAESAQAAMKENGLKWGLLPTPVDFFDETIDEKKFEEALEIQKRWAQLGEKIGVKYAYNHIWPSSSREFDENFEWHVKRLEKLQEVFVNHGIQYGFEFLGPKELRVRHPHPFVHTISGVLSIADAAGGKTGFLFDTYHWYCGSGRLDDLYFAAQNCHRMVNFHLNDGVAGKSRDEQEDQVRAMPMTTGIIDAARIYQLFEKNGYKGPVMCEPMVPSTDRFAVQDVEKSMAEVKDAFNRCSGIISTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFG1</accession>
    <name>F7KFG1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254491.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04590"/>
    <dbReference type="EnsemblBacteria" id="EGN35037">
        <property type="protein sequence ID" value="EGN35037"/>
        <property type="gene ID" value="HMPREF0994_04590"/>
    </dbReference>
    <dbReference type="GeneID" id="29723459"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5011"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN35037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="376" mass="41959" checksum="B87AE0FAB94CB0E7" modified="2011-09-21" version="1">MVPVFSQEKIYGYDFEACGGCRTDCCRRDKPAVRPACINDWRNGKITLDNIAKELGVSKSTVSRALSGKGRIGEATRQKIQAYAREQGIWQEKKQKEDPVRTENIAVVIPMDAYSTNVPFFQECLLGISEMATMLRYNVLITIGTPNDISNVQRLVEKKQVDGIVLLRDLEHDRLLQYLTEIHFPAGLSGTCDYEEIIQVDIDNKAASNSLVSLLIGQGYRRFAMLFGEMSFRVNQKRCQGCYDALDKYGLSRAHQLCYSDFDNTELLNSIISDMFAGKVECIICGDDVICTKVMSALQAEGYRIPRDISIASLYNSANLNCFSPAVTAISVSARQVGNVVGRQLINSLRGEAYNAKTNLGYEILLRKSTGKMYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFI7</accession>
    <name>F7KFI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254517.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04616"/>
    <dbReference type="EnsemblBacteria" id="EGN35063">
        <property type="protein sequence ID" value="EGN35063"/>
        <property type="gene ID" value="HMPREF0994_04616"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032C95">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1989746_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="13877" checksum="BE662E6F3B7BA4A3" modified="2011-09-21" version="1">MENKKKENELNELIHASMQLNDTPSPDLNKRLKVSLYQREAILRQAAPICAVPLWFVPMILNVITFSLFAILALSVITNPFFARLAAGLCIYMGAAGILLTAVGVKRTDMKKDLTVHIQKRGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFK0</accession>
    <name>F7KFK0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254530.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04629"/>
    <dbReference type="EnsemblBacteria" id="EGN35076">
        <property type="protein sequence ID" value="EGN35076"/>
        <property type="gene ID" value="HMPREF0994_04629"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5054"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="33548" checksum="E8857D05B1F99ECC" modified="2011-09-21" version="1">MKGKKNTGGPFSYTFRKKAAPWCILALPMAFTAWLKYYPILSAFFISLFKYDPINPPGKFVGLSNYIGMFKMQYYWDAWKNTFIFLLLQLAMCFFIPLIQALFLNELIRLQKCLTTLYILPALIPTSVNVIIWKWIWHPDYGVANQIIKFFGGQPQAWLSDPGLVKFCIIFPGVLGGGLTVLLYLSAIQGVSSDIMESAALDGCTGFSKIFRIILPNISFMIFIQLIMCVITTMQLLDAPYMYASGGPSGASTTQGIFIYNAFNQDLNYGRGSAASIVLLLVIAGLTMLQMHFEKSEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFL8</accession>
    <name>F7KFL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254548.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04647"/>
    <dbReference type="EnsemblBacteria" id="EGN35094">
        <property type="protein sequence ID" value="EGN35094"/>
        <property type="gene ID" value="HMPREF0994_04647"/>
    </dbReference>
    <dbReference type="GeneID" id="29723567"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_2_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="175" mass="20196" checksum="EEBBCD9EF3507025" modified="2011-09-21" version="1">MNLSTKIYELRKAKGMSQEKLAELVGVSRQSISKWESGETIPELERLVELSRIFEVTTDYLLKPGEMDELTIRTEKLEKRQNDLQSEVRKEHSKNIRILSTGFIYAIALAIFFYLQLPFPYLWPLGTGMTVRLIVLAVVLLIATAIAIQNNLWITKKYWKQSEEEETGGKSDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFQ1</accession>
    <name>F7KFQ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254581.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04680"/>
    <dbReference type="EnsemblBacteria" id="EGN34800">
        <property type="protein sequence ID" value="EGN34800"/>
        <property type="gene ID" value="HMPREF0994_04680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5111"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="400"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="502" mass="58127" checksum="A6026FAD832B57AC" modified="2011-09-21" version="1">MYEILIVDDSVLDIDCILFLIDKYKLPLHATTAVNGQEALRQLQAGERHFDILFTDIKMPLMDGLELSRETRRLSPDTRIIIFSGYNDFEYAKTAITIGVQDYLMKPIVPADFAATVSRLISAIEEDGRLAEQMQKRTRLLKSHRLLLSVNNCLSKEEMDAISDEYSHLMLLECEEEFFSQEALDFQDKLEELLPFTFDYLNLYPTRSLIFIRQDNEARFKKESYLLSAAQTISLSAGEEYGRKCYITFGSLQGRASISQVYQRLEKKIETRFFFPERTCLLPDNSMQSQSVSGHISMDMITDDLKLKDYGSLKQHMEEIFDSLKDEKTHSLIYVKYCFTELMKELTASLPPTARPDLVSLAEQIYTSSNITQLIDMARTLMEQLTSVSEASDKDNLKIEKIKQYIYQNYASPLTLDDIAAAFYISPNYLCSVFKKETGCNLIKFINDYRLQRARQLLLTTEMKVHMIAETVGFKNTSYFCQRFRDYYGESPESCRQKETRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFR6</accession>
    <name>F7KFR6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein HMPREF0994_04695</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254596.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04695"/>
    <dbReference type="EnsemblBacteria" id="EGN34621">
        <property type="protein sequence ID" value="EGN34621"/>
        <property type="gene ID" value="HMPREF0994_04695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5125"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="115" mass="12341" checksum="46DB9689AA3BB755" modified="2011-09-21" version="1">MAKRGGFPGGGMPGNMNNLMKQAQRMQRQMEESQKELETKEFTAKAGGGAVEVTVTGKKEITKVKLSEEVVDPDDIEMLEDLVVAAANEALRMAEEANTEMMGKMTGGLGGGFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFZ9</accession>
    <name>F7KFZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254679.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04778"/>
    <dbReference type="EnsemblBacteria" id="EGN34405">
        <property type="protein sequence ID" value="EGN34405"/>
        <property type="gene ID" value="HMPREF0994_04778"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5220"/>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="32233" checksum="AE7D1025693CEB44" modified="2011-09-21" version="1">MLHTAFTPYEEFLVEYVRKPGRNDMKVQHYHDTYEFYLQMAGERTLILNDICYTLRPGDLYILKPFEIHYTESRGSDYYERYVINLPASFLYTLLTEGETRLLLDKLESCVLHLSPEQAAEALGCFQRAEQFRRKTGFLAGKLLCSSIFQLLMFLTELTEKAGLPDILEGKSIQPEIVKAIHYINRNYQENLSLEGAAELVHLSRYHFCRLFHEATGATFLEYLYNVRLAKVHQLLLTTTLPLGDIAAKCGFASTAHLSRVFREAYGMSPRSFRKTALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG62</accession>
    <name>F7KG62_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254745.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04844"/>
    <dbReference type="EnsemblBacteria" id="EGN34471">
        <property type="protein sequence ID" value="EGN34471"/>
        <property type="gene ID" value="HMPREF0994_04844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020211_13_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="330"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="434" mass="51123" checksum="D394AB2628F7F32D" modified="2011-09-21" version="1">MIVLRIWEGILSIVEILGIFYILFMFSEKRGAGKWKSGLLLFLMTAVSLLLIYQRITSGLYSRYFMLTCICISSVIAWLCFKMAFWKCFILTALYFETISLFDVLFVYIWTVAVKEIQFAENIQLQMSAERVVIMAFSRAILMGMVFWSVNCRAVVRRVFIKYKKIFAFFVLLEYIVLLYCDQVFLFMGNRKIDIYFVFFPLLLLLVMAWTVSFIIYFEKKDEITAIHIRNDMMEKNYQDMVMLYQQRDIISHDIKNHLVILSSLMEEEEFNKARQYVKKIQEPIKALDQRRYTRNRIINSIMNDKAKKAKLFDVSLNIKVVGNFMTAVEDIDWCAILANLLDNAIEACEKVTVEERRIDFSLVRKDEMIILDISNPYCGNVKLMDGKLYTLKEDKMLHGIGMESVKYAVEKNNGTLEYSFMDHIFRVNIVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGD7</accession>
    <name>F7KGD7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilus assembly protein PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04916"/>
    <dbReference type="EnsemblBacteria" id="EGN34206">
        <property type="protein sequence ID" value="EGN34206"/>
        <property type="gene ID" value="HMPREF0994_04916"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5370"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="313"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="559" mass="62599" checksum="A8504D9F0D4DCD59" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGF7</accession>
    <name>F7KGF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe-ADH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254837.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04936"/>
    <dbReference type="EnsemblBacteria" id="EGN34226">
        <property type="protein sequence ID" value="EGN34226"/>
        <property type="gene ID" value="HMPREF0994_04936"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5390"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="388" mass="41915" checksum="AE02C39479ADFCC2" modified="2011-09-21" version="1">MKEFTYYAPTEILFGCGKVAEIGNVTKRYGKRALLVTGSSKSTEVIAEKALRFLQEAGIDTAHFNGVKPNPTTDIVTEGAAIAKKHGVQVVVGLGGGSCVDTAKAIAVEATNEGTVWDYNCHTQGPTEKTLPIIAVGTTAGTGSQVTQCSVITHTSSKDKSAIWHRNIFPKVAIVDPDLTASMPKQITAQTGFDAFCHNFEAYISVNTSPMVEKLALEAIRIIVENLPKALKNGNDMEARSQMAWADTLGGMTNSNAGVTLPHGLGMQVGGHCPQVSHGQALAAFYPVFTRYTYPAAVEKFAAVGRIFNPELCDRDNAYAAEQCCEEIDGFLKCIGLWIGYKELDVSMEDIREIADCGQVLGDYLNNPRIATIEEMYELLVNSYERQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGG6</accession>
    <name>F7KGG6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polar amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254846.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04945"/>
    <dbReference type="EnsemblBacteria" id="EGN34114">
        <property type="protein sequence ID" value="EGN34114"/>
        <property type="gene ID" value="HMPREF0994_04945"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="247" mass="27578" checksum="866093FFA7679457" modified="2011-09-21" version="1">MNADGQLLFEIRDLCKSFGDIEVLKNINTTISQGEVVVIVGPSGSGKSTFLRSLNLLEEPTGGQILFEGKDITDPKANINLYRQHIGMVFQHFNLFPHKTILQNMTLAPVQLLKRSKKEAEEEAMKLLERVGLPEKANAYPSQLSGGQKQRIAIVRSLCMHPDVMLFDEPTSALDPEMVGEVLGVMSDLARDGMTMVIVTHEMGFAKEVGSRVLFMDDGMIKEESAPREFFDNPKNPRLREFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGQ8</accession>
    <name>F7KGQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254938.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05037"/>
    <dbReference type="EnsemblBacteria" id="EGN33746">
        <property type="protein sequence ID" value="EGN33746"/>
        <property type="gene ID" value="HMPREF0994_05037"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5502"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="574" mass="62189" checksum="20CC84E07A3C1CBA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHA2</accession>
    <name>F7KHA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002595844.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05241"/>
    <dbReference type="EnsemblBacteria" id="EGN33274">
        <property type="protein sequence ID" value="EGN33274"/>
        <property type="gene ID" value="HMPREF0994_05241"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5724"/>
    <dbReference type="eggNOG" id="COG2253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067323_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="32645" checksum="41BA48B730865B03" modified="2011-09-21" version="1">MIKTARQLKDLIRNLSREKSADAQILMRNYMMERFLERISLSEYRDKFILKGGMLVAAMVGLDARSTMDLDATIKGANVNVEDIENLISSIVTVPIDDGVKFQLKSISEIMDEAEYPGIRVSMSTTFDGVVTPLKIDISTGDAITPREVRYSFKLMLEDRSIDIWAYNLETVLAEKLETIITRTTTNTRMRDFYDIYILEQLHGTTLNPKILHDALLATAHKRGSEKYLNQAEEVFDEVENDSVMQKLWEAYRKKFSYASDLEWDVIMKAIRRLYVLCEKGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHA3</accession>
    <name>F7KHA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002588981.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05242"/>
    <dbReference type="EnsemblBacteria" id="EGN33275">
        <property type="protein sequence ID" value="EGN33275"/>
        <property type="gene ID" value="HMPREF0994_05242"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5725"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089333_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="198" mass="22926" checksum="A324BB798EE1946D" modified="2011-09-21" version="1">MMGQFEQLDQMLTEQEGMLRTSQVVSSGISKPVFYDYVRSRDLDRVAHGIYLSKDSWVDAMYLLHLRFEQAVFSHETALFFHDLTDREPIEYTVTVKTGCNPSKMKAEGIQVFTIKADLHDVGLTTAKTPFGHTVPVYDMERTICDLLRSRSRIEIQTFQGALKAYARRKDKNLRALMQYAGMFKVEKILRQYLEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHD8</accession>
    <name>F7KHD8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="11" type="ORF">HMPREF0994_05138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255039.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05138"/>
    <dbReference type="EnsemblBacteria" id="EGN33171">
        <property type="protein sequence ID" value="EGN33171"/>
        <property type="gene ID" value="HMPREF0994_05138"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5615"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="12"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="814"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="531"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="822"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="855" mass="96759" checksum="5FF7EA8B84F14155" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHH6</accession>
    <name>F7KHH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255148.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05305"/>
    <dbReference type="EnsemblBacteria" id="EGN33040">
        <property type="protein sequence ID" value="EGN33040"/>
        <property type="gene ID" value="HMPREF0994_05305"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129249_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="174" mass="20113" checksum="B0C63BDF536C085E" modified="2011-09-21" version="1">MATFYLVRHGQTDYSERNKKIYQGFGVNLSPLSTDGVKEIINTSKDKRLCEACVILSSPYTRAVQTAAILSKELQIDIIIETDLHEWMANKNYVYEDDAKAENNYREFVKFKGTYPADCNMDWEDVLSMRNRILPVLEKYKQYPKIIVACHGMLIQSLCNGYHPKNGEIVEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHU3</accession>
    <name>F7KHU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255275.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05432"/>
    <dbReference type="EnsemblBacteria" id="EGN32873">
        <property type="protein sequence ID" value="EGN32873"/>
        <property type="gene ID" value="HMPREF0994_05432"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5938"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="443" mass="47839" checksum="B6F4DE095DE12F16" modified="2011-09-21" version="1">MNQDFMRTKPILPLVLSMALPMMLSMLINSLYNIVDSMFVARLGEQALTAVSLVYPLQTLIVSIGVGFGVGINAAVAFFMGAGEKEKADRAASQGLFLSLVHGILLSVGTVICIPYFLPMFTADNLILAWGKEYAVIVLSFSVVVTVQIAFEKIYQSTGNMFVPMVCMAAGSITNIILDPVFIFGLGPVPRLEVKGAAIATAIGQVVTLLLYLIWYFKKDMGLSIKKTYMKPTADICRRVYMVGVPCSMTMGLPSLLITILNGFAAAFSPIYILILGVYFKLQSFIYLPANGIVQGMRPILSYNYGADERKRMKRIIQICGAMILAIMAVGMLLFLVFSGSIMKMFTVDAVTVREGALALRIISFGFVVSGVSVVCSGALEALGKGFASFLISLLRYLALIVPAAYLGIRIAGVIGIWTAFPAAEALTAAASVIIFVICYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHY0</accession>
    <name>F7KHY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05473"/>
    <dbReference type="EnsemblBacteria" id="EGN32914">
        <property type="protein sequence ID" value="EGN32914"/>
        <property type="gene ID" value="HMPREF0994_05473"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3291355_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="40" mass="4522" checksum="1EE94CF42FF83AC1" modified="2011-09-21" version="1">MHTADGFVMNMANMGCMGMCRMEGMFNKVRMKTAVRRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHY5</accession>
    <name>F7KHY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255324.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05481"/>
    <dbReference type="EnsemblBacteria" id="EGN32922">
        <property type="protein sequence ID" value="EGN32922"/>
        <property type="gene ID" value="HMPREF0994_05481"/>
    </dbReference>
    <dbReference type="GeneID" id="29727484"/>
    <dbReference type="eggNOG" id="ENOG5032P10">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132461_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="28926" checksum="435A9CD908CEE3EE" modified="2011-09-21" version="1">MEAINGVSDILNEEQILMSEWEKQWKECHIEYPYFNQDGIVSYEKWSQLPEGKHILVILKETDALEGSLAEFLRNGGSDTYYRTWNNVARWTRMILDGIYLDRVDRELLDNSIKEIAAINLKKYAGSARANNREVKKIALEDVDLLRRQVRLYQPDIILTGGWGMVSDFLHDYILEEDRAWYDPRKRKDREREPDLWYFRTDKVCEGKSTLVISMPHPNRAAKKWTLELQKVLWKEEILAKAMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHY6</accession>
    <name>F7KHY6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571065.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05482"/>
    <dbReference type="EnsemblBacteria" id="EGN32923">
        <property type="protein sequence ID" value="EGN32923"/>
        <property type="gene ID" value="HMPREF0994_05482"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5993"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="167"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="46190" checksum="05016AF6F282E00B" modified="2011-09-21" version="1">MAKKNRSVPQYGTVMRKGILYYRTRIQDADGKQVSLYATTCEELYEKQQAAKKQVEEIVFRRKHPTVAEYCEKWLLMQSAKVSSATMKAYTSDMRNYIIKPLGDMYMEEVTADDIRLALVPLTNKSEGLYNTVNMLIKCIFYSAERSELITYNPCVGISAKGGKPTKKKDALTDQQVEVLLDTVKGLPPYLFIMICLYSGLRREEALGLHWDCVFLDAPTPYISVRRAWRSEHNRPVVSTVLKTPAAKRDIPIPKCLVDCLREAKENSISDYVIADSKGEPLAYSQFQRVWQYVVVRSTKPRNYYKYVNGESIKYTVTPTLGMTQKNQPKIKYTIDFDVTPHQLRHTYITNLLYAGVNPKTVQYLAGHENSKTTMDIYAKVKYNKPEELFEVVNDALHQRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIC1</accession>
    <name>F7KIC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255407.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05600"/>
    <dbReference type="EnsemblBacteria" id="EGN32311">
        <property type="protein sequence ID" value="EGN32311"/>
        <property type="gene ID" value="HMPREF0994_05600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6117"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="33165" checksum="F4BE3578AE463FC9" modified="2011-09-21" version="1">MKQSKLQRKVSGVGIVSCCIVTLFAVLCLVPFLYIIAASFSDESSLIREGYHLLPRKISFEAYQMVLGGRQIWDSYKVSIFTALAGTFLSLFFSSMLAYPLSTKRMKYGPAINFYVYFTMLFSGGLVPTYILISRYLKLTNTVWVLILPVLVIPWNMFLLRNFYASIPASLAESAKIDGANEFTILVRIILPCSKPALATVGLFYALGYWNEWFKAMLYNSGDKETWPLQYLIMQLIRKAETITNMAAQGMNISSANMPSSTMKMATAICTIGPIVLAYPFAQRFFTGGIMVGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIF7</accession>
    <name>F7KIF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255443.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05636"/>
    <dbReference type="EnsemblBacteria" id="EGN32347">
        <property type="protein sequence ID" value="EGN32347"/>
        <property type="gene ID" value="HMPREF0994_05636"/>
    </dbReference>
    <dbReference type="GeneID" id="29728500"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6160"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862595_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="336" mass="39026" checksum="4D5DFF715DB8F2BA" modified="2011-09-21" version="1">MMKEEANTRYLVRSYEPSDWIRHMEEGTQAVNDFYLPEGPFEKNEMSDTIYHEGTKVNYHEHSRGFETFFIAKGSVECTIRGKKTVAQAGDIVHLQPYTPHGFVFLEEGTIWRELFQEINMQQGILNKNMILNHYPELYDEPEFMAMYREANGSFTREKEVQDIAPVVPKSEIPEIREPGFSWARHRGDGWELKLKVGRFECSGAKEVWEVNLDAGITIEYQDPHPYFELYYITKGKVKFTVLEGFEDEAAFVADAGCIVRIPPYAKHTMEVVEDAQMFDNGCEIRLMSMLEDLAAVRAARPEELEDPVLKKKFLRKYKCFVTAFYKKEKISGEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIG7</accession>
    <name>F7KIG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255453.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05646"/>
    <dbReference type="EnsemblBacteria" id="EGN32270">
        <property type="protein sequence ID" value="EGN32270"/>
        <property type="gene ID" value="HMPREF0994_05646"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6171"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="32491" checksum="4D5B92C2972EE26E" modified="2011-09-21" version="1">MKKKNSNGWGFRLINGIILAMISLMTLYPFLYVIFASFSDPVKLMGNSSLLLKPLGFSLNAYKKVFVNPSIYSGYLNTIFYVAAGTLVNILATCMAAYVLSRKQFMLRRFLTIMFIFTMYFNGGLIPSYLLIKDLGLINSRLSLILPGAVSTFNLMIMITGFEGIPQSLEESARIDGAGDWTILFRIIMPLAKPTIMVILLYYAVGHWNSWFNAMIYLRDADKMPIQIFLRDILTRSQLGAMTGQTDVEDVGQTIKYATIIVSTVPILCIYPFIQKHFVKGVMIGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIH2</accession>
    <name>F7KIH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255458.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN32275">
        <property type="protein sequence ID" value="EGN32275"/>
        <property type="gene ID" value="HMPREF0994_05651"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6176"/>
    <dbReference type="eggNOG" id="ENOG5030ETV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155222_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="115" mass="13650" checksum="1EBDD2C97C16C4EE" modified="2011-09-21" version="1">MFNEICIYEAKIDKQDEIEALMKEVAEFYLSQPGVIDVKYIKRTHRQEDFNAVKEGKPPIRLTKWVGKVTYILHWTLENEDVHAQVSRLGLEHFYKRWNRCLTTMPKILLGENIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIQ7</accession>
    <name>F7KIQ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004607969.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05745"/>
    <dbReference type="EnsemblBacteria" id="EGN32234">
        <property type="protein sequence ID" value="EGN32234"/>
        <property type="gene ID" value="HMPREF0994_05745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6283"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041511">
        <property type="entry name" value="DBD_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18430">
        <property type="entry name" value="DBD_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="117" mass="13317" checksum="6DF55A82FCDECD98" modified="2011-09-21" version="1">MAKRPVPKYDFKAFGAAIKAARTGRKESRKKVSDEMFISPRYLANIENKGQHPSLQIFFELMLRYNISVDQFLLETPPEKNTQRRQLDALLDGMSDTGIRIVSATAKEIAEVETEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ54</accession>
    <name>F7KJ54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255662.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05886"/>
    <dbReference type="EnsemblBacteria" id="EGN31514">
        <property type="protein sequence ID" value="EGN31514"/>
        <property type="gene ID" value="HMPREF0994_05886"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6439"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="571" mass="61318" checksum="C15BAB18D2BA0F76" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJQ0</accession>
    <name>F7KJQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31443.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359911.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06089"/>
    <dbReference type="EnsemblBacteria" id="EGN31443">
        <property type="protein sequence ID" value="EGN31443"/>
        <property type="gene ID" value="HMPREF0994_06089"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="422"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31443.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="523" mass="60513" checksum="8F433D7F340C59AA" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJS2</accession>
    <name>F7KJS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255877.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06101"/>
    <dbReference type="EnsemblBacteria" id="EGN30727">
        <property type="protein sequence ID" value="EGN30727"/>
        <property type="gene ID" value="HMPREF0994_06101"/>
    </dbReference>
    <dbReference type="GeneID" id="29724108"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6683"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033331_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="453" mass="50619" checksum="0BC9824864130EF9" modified="2011-09-21" version="1">MLKDKMLWMKDSGNIRDEIRQCREEGRMISDLLPRAEEILSMEEGPEKESCARQFLLELENCPVDEAFPFEEPVEWEKLAAACEGNGIHLQIPEEELQDRIWGAWTGRASGCLLGVPVEGWSRGKIRGYLEESGQYPLEGHIRSDTEREVREKYGVKDVDEGTAYDRQNICWINNMDTYPVDDDMNYTVLSLRVLERSGSNFTSEDVAQSWLFGLPAFHTCTAERVAYRNLMHGILPPESGILANPFREWIGAQIRVDFYGYIAAGNPALAAQMAWRDAVVAQTKNGVYAAMYIAALIASAPVLPKPSGWVEEAMKQIPRNCRLYAALKELLDSWKKGASWEELLEAIHGKYEESNSFDWCLAIPNALIVTACVLCFGTDYSQAVIHAVLAGFDTDCNGATVGSVVGIALGCGGIDSRWTEPVKQIICSSVNSYTRFSVEEVTERTIAVMKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK14</accession>
    <name>F7KK14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore cortex biosynthesis protein YabQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06204"/>
    <dbReference type="EnsemblBacteria" id="EGN30697">
        <property type="protein sequence ID" value="EGN30697"/>
        <property type="gene ID" value="HMPREF0994_06204"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6794"/>
    <dbReference type="eggNOG" id="ENOG50339JQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113225_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019074">
        <property type="entry name" value="YabQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09578">
        <property type="entry name" value="Spore_YabQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="202" mass="23210" checksum="FC042ADE0E2F8FF0" modified="2011-09-21" version="1">MAEKGNLFSPGFSSRCAVSPVIAGEGVFILHSFLLGVVITFIYDLFRIVRRIIPHGWFLLSLEDLAFWILATAGIFYMLYYENSGMFRWFSVIGAGVGMFLYKKTLSAPFVNLVSGAVNRLLALLGKFLWKLTAPVRFVWHKLTVLAGRGARRAAREARIRRRQVKYRLTAWKKAIRMNLCKRREKRQDKKKMRQRDAGDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK91</accession>
    <name>F7KK91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06270"/>
    <dbReference type="EnsemblBacteria" id="EGN30189">
        <property type="protein sequence ID" value="EGN30189"/>
        <property type="gene ID" value="HMPREF0994_06270"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2070062_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="118" mass="13126" checksum="2F10E4F69F0392F0" modified="2011-09-21" version="1">MGGTPPVRYLPCVVPCKLYFMNVEVKGEQAGKILAAELQECIIVIHGIDGARCYWKQEQVVETTQKVEQPKILTGAGDHFNAGFCCGMLNKLGLRDSLRLGNKAAGYYIRYGRDMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLJ0</accession>
    <name>F7KLJ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256481.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06728"/>
    <dbReference type="EnsemblBacteria" id="EGN46652">
        <property type="protein sequence ID" value="EGN46652"/>
        <property type="gene ID" value="HMPREF0994_06728"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7356"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN46652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="197" mass="20609" checksum="0FA1FFA324B4C158" modified="2011-09-21" version="1">MELIAKLFGVFLQIGCFSIGGGYAVISLIQNQIVGKYGWLTEKTFGDIITISQMTPGPLAVNASTFAGFQLAGVWGAAAATAGCVAGGIVLSLLLYVFFKKKGNSFYMTHLLRGLKAASTGLILSAAGTILLLTFWGSSDIGQLSLSGIEIRSVALFVSALLLPRIIVPLFTKGKVKGLGPVALMLLTGAAGFFLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLK7</accession>
    <name>F7KLK7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9 11">Uracil-DNA glycosylase</fullName>
            <shortName evidence="9">UDG</shortName>
            <ecNumber evidence="4 9 11">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ung</name>
        <name evidence="13" type="ORF">HMPREF0994_06745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9 11">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 11">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 11">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 9 11"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256498.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06745"/>
    <dbReference type="EnsemblBacteria" id="EGN46669">
        <property type="protein sequence ID" value="EGN46669"/>
        <property type="gene ID" value="HMPREF0994_06745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7372"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="225" mass="25881" checksum="A72BFDB8C516809C" modified="2011-09-21" version="1">MGMIQNDWLDEISGEFKKPYYAQLFRFVQKEYSTYVVYPPADEIFNAFHFTPLSKVKVVILGQDPYHNENQAHGLSFSVKPEQKEIPPSLVNIYQELHDDLGCYIPNNGYLKKWADQGVLMLNTVLTVRAHRANSHQGQGWEQFTDAVIEAVNHQDRPVVYMLWGRPAQSKIPMLTNPKHLILKAPHPSPLSAFRGFMGCRHFSQANDFLKNNGVEPVDWQIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLK9</accession>
    <name>F7KLK9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ORF">HMPREF0994_06747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256500.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06747"/>
    <dbReference type="EnsemblBacteria" id="EGN46671">
        <property type="protein sequence ID" value="EGN46671"/>
        <property type="gene ID" value="HMPREF0994_06747"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7374"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_2_2_9"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN46671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="202" mass="22019" checksum="D1D99378645B6E84" modified="2011-09-21" version="1">MVAIIDYDAGNIKSVEKALQALGENAVITRDKACILEADKVILPGVGAFGDAMQKLEDYGLTDVIREVAEKGTPFLGICLGLQLLFERSEESEGVDGLGILPGEILRIPEAPGLKIPHIGWNSLSYPNPGRLFTGVKENSYVYFVHSYYLRSSDPSIVTAETEYGTRIHASVEKDNIFACQFHPEKSSAVGLTILKNFISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRG5</accession>
    <name>S2KRG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EPC05034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360346.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07320"/>
    <dbReference type="EnsemblBacteria" id="EPC05034">
        <property type="protein sequence ID" value="EPC05034"/>
        <property type="gene ID" value="HMPREF0994_07320"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="31254" checksum="34F22CC93DDB8BD2" modified="2013-09-18" version="1">MAIVSVKEILEHAWGHKYGVPAINVFNYETVKWAIEAAEEERLPIIIQFYPGFAEHIALKYVADFAVDMAKKARVPVAVHLDHSPSYEIAVGGIRDGFPSVMVDGSVLPYEENVELTRAVVRVAEVFGVDVEAELGHVGSGSSLDDIVNEKNYTSIEDAVDFTERTGCGSLAIAVGNAHGVYIREPRLDFDRIRAIRSAVKVPLVLHGCSDIPDDQLKESVNLGLSKFNIATEYDRAFYTAIAARADKTEQKGSFFRLQEEAAKDIRAFVAGKLRLLNPNGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS18</accession>
    <name>S2KS18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360179.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07226"/>
    <dbReference type="EnsemblBacteria" id="EPC05077">
        <property type="protein sequence ID" value="EPC05077"/>
        <property type="gene ID" value="HMPREF0994_07226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004510199" evidence="1">
        <location>
            <begin position="30"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="557" mass="61195" checksum="190DDA17CDA8ABA5" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSB6</accession>
    <name>S2KSB6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M56 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359827.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07027"/>
    <dbReference type="EnsemblBacteria" id="EPC05359">
        <property type="protein sequence ID" value="EPC05359"/>
        <property type="gene ID" value="HMPREF0994_07027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013716_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="8"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="563" mass="62682" checksum="5A8F646A42BACFE1" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSD0</accession>
    <name>S2KSD0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RelA_SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360044.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07144"/>
    <dbReference type="EnsemblBacteria" id="EPC05197">
        <property type="protein sequence ID" value="EPC05197"/>
        <property type="gene ID" value="HMPREF0994_07144"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646806_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="44"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="414" mass="47345" checksum="61739A1BF053536A" modified="2013-09-18" version="1">MDLINQFIENYKKKIKFYETAGRIAADMLDDSLRSSGIRAMVTSRAKSPGRLKIKVSQRNEKRETPYKNMGEIYADIADLSGVRVSLYFPGDRAKADRVINNLFAVAETKKFPVQSKQPSYNKRFSGYWATHYRASMKEESLEKSKLKFAPVRLEIQVASVLMHAWSEVEHDLVYKPLQGTLSDEELSILDELNGLVLSGEIALERLQAAGNERIQSKNTAFNNQYDLAAYLYNYLSTRYKRFDIEPRMGNVELLLRLMGRLKIANVKELEPILKSTKLVNDKRTITEQLIDQIICGNEKRYHLYRELRAPGEKLAKDQFQAMEYFMKPWISLETVLGRLTLKSNPKARGTFNVNSLKRMKVLSKESLDKVVALRNARNGLVHGIEYPTTAAMIKMGDDVRSILSQLSDAPQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>S2KT06</accession>
    <name>S2KT06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_07060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359887.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07060"/>
    <dbReference type="EnsemblBacteria" id="EPC05392">
        <property type="protein sequence ID" value="EPC05392"/>
        <property type="gene ID" value="HMPREF0994_07060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="5">
        <location>
            <begin position="107"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="439" mass="46733" checksum="669A5AAB9C2568F9" modified="2013-09-18" version="1">MDRRDRRRKRRVRNQIISYIVAVVLLAGLVTGGFFGVRHISNAMEEKKQQEESQSQEESLAQAEAMEQTASEADGAGEETSETESVESQEEILEELVEACVADMSLEDKVAGLFIITPEQLTGVGTAIQAGEGTQEALKKYPVGGLVYFAKNIQSEEQLKEMLAKTVSYATYPLFLGVDEEGGSVARVADQLKLTNVGPMADIGAGGDPGAAYTAGQTIGNYLKDYGFNLDFAPVADVLTNPDNKVIGDRAFGSDAAVVSQMVASAVQGLQDTGVSACIKHFPGHGDTSGDSHEGAVETDRTAEEMQGTEFLPFQAGIEAGTDMVMVGHISAPGLTGGDAAPASINENIITGVLRRQLGYDGIVITDAMNMSAISEYYTADEAAIKALKAGADMILMPEDFVTAYEGVIAAVKDGTIDENRINDSLKRVYRVKYAGTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>S2KW76</accession>
    <name>S2KW76_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA-ATPase_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07094"/>
    <dbReference type="EnsemblBacteria" id="EPC05245">
        <property type="protein sequence ID" value="EPC05245"/>
        <property type="gene ID" value="HMPREF0994_07094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021114_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="447" mass="52631" checksum="9D887BC70B00E78D" modified="2013-09-18" version="1">MYLPKENNYEKKLPIGIEDFKEIIEKDCYYVDKTLFIKELLDNSSKVRLFTRPRRFGKTLALSMLRYYFEKEITVEGRAGYNSRLFRGLKILDAGESYLSHMGQYPVISLSLKSAKQPSFEMAYASILDELALEFDRHKSVLYSDELSEDEKALFERFIKRQASEWENFKALKFLSKCLQKVYQKNAIILLDEYDVPLENAWFRGFYEQMTFFIRSLFESALKTNPSLEFAVITGCLRISKESIFTGLNNLEIISVLSSRYSEHFGFTVPEVGNMLHFYDIEEKKEEVKRWYDGYFFGNTEVYNPWSMINYVNEAVSNINSLPRPYWANTSSNGIIRDMIEHADNSIKLELENLIAGECIEKPVHEDITYEEIHESEDNLWNFLFFTGYLKKVREHMQADTVYITLAIPNAEVKNIYRNTIMKWFDGQIQPGKRYGEKRYYYPFGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2F7</accession>
    <name>F7K2F7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4316 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249985.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00036"/>
    <dbReference type="EnsemblBacteria" id="EGN48269">
        <property type="protein sequence ID" value="EGN48269"/>
        <property type="gene ID" value="HMPREF0994_00036"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.39"/>
    <dbReference type="eggNOG" id="ENOG502ZAZV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908121_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025465">
        <property type="entry name" value="DUF4316"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14195">
        <property type="entry name" value="DUF4316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4316" evidence="2">
        <location>
            <begin position="226"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="35236" checksum="91551AB04EA9E97F" modified="2011-09-21" version="1">MEKEKTYGVWAVRSAASIFGRAESWCKEAGRPLEFASQETAEAYAKECNSRTTANVHYFVKEKEPEPGAVRKDGTQPDRAARAHEEQTPRNAAMEKLNEIPGRQLSKDPDPLVEIRSAVHSNYAGMVAMLAADNRVYLGREEHYHYQDGLTSYYDNGDGSLCFVTDRADMYYFLYGEGWAHSQAEMLERGLTSDQYAEFARLQNGVLRQFEAQREILFAGQPFQPPESYLRNAELYEEGQTGNYNMLDGRLNNEPPVKPDLTDGQTHEEIRELAPETLPEEKPSVLDRLKSERPEHEARQITPPVPERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2H4</accession>
    <name>F7K2H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250002.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00053"/>
    <dbReference type="EnsemblBacteria" id="EGN48286">
        <property type="protein sequence ID" value="EGN48286"/>
        <property type="gene ID" value="HMPREF0994_00053"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y4B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173863_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="70" mass="7844" checksum="9CF059957D37A8C1" modified="2011-09-21" version="1">MENITAGGSGSLVDIRDVTVDKELPREERITEFVRQIKNPYRFKCGRFTVRASFAPGGATLEECIKGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2I8</accession>
    <name>F7K2I8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250016.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00067"/>
    <dbReference type="EnsemblBacteria" id="EGN48300">
        <property type="protein sequence ID" value="EGN48300"/>
        <property type="gene ID" value="HMPREF0994_00067"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.71"/>
    <dbReference type="HOGENOM" id="CLU_1183823_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025671">
        <property type="entry name" value="HXXEE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13787">
        <property type="entry name" value="HXXEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="232" mass="26742" checksum="97C6AEC9D4D98C25" modified="2011-09-21" version="1">MVRKLDKWCDIDWIIFICVTGVITAVCAALFWDNMPLGAQGAVFAAVIMPFHVLEEWKFPGGLHHFYNTLLGPKEKNRQDLSRYPMSRLTDMVTNVGLQWIPLVYLLLSCVTSLSNAVTLCMMLFCFIEVLAHTCAGFMTLHWYKKDGKKTIYNPGFATSYMMFLPCGIYLAVRLNNITGRDWLWCVILLVVMMLICIPLSETPLKKWVIRQEKGMFAFADPKYYSQFIHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2J0</accession>
    <name>F7K2J0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250018.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00069"/>
    <dbReference type="EnsemblBacteria" id="EGN48302">
        <property type="protein sequence ID" value="EGN48302"/>
        <property type="gene ID" value="HMPREF0994_00069"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183823_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025671">
        <property type="entry name" value="HXXEE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13787">
        <property type="entry name" value="HXXEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="234" mass="26073" checksum="9F90F829F40CF470" modified="2011-09-21" version="1">MVKKLDKWCDIIWLVCLGILGVIVAFLLILNWNSWTPGAKGGAFLAVIMPLHVLEEWKCPGGLHYIYNIIFGPKDFGSRYLDRYPMSRFTDMITNIGLAVIPLIYAVPAQIGGMSNMVAICIIILSFGEVLAHTVVGCYSLKRYRKAGKKFIYCPGFFTAYVLFLPTGVYLCSQISNVTATDVLGGIIAMAILGIVCVPLQETPLKKWVLKQEGDTFAFADPKYYAKFTDKDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7K312</accession>
    <name>F7K312_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ORF">HMPREF0994_00241</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250190.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00241"/>
    <dbReference type="EnsemblBacteria" id="EGN37880">
        <property type="protein sequence ID" value="EGN37880"/>
        <property type="gene ID" value="HMPREF0994_00241"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.261"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="255"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGN37880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="590" mass="67477" checksum="244C5C8E750B19D9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K352</accession>
    <name>F7K352_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00281"/>
    <dbReference type="EnsemblBacteria" id="EGN33422">
        <property type="protein sequence ID" value="EGN33422"/>
        <property type="gene ID" value="HMPREF0994_00281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175464_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="107" mass="12275" checksum="7F274B0F1AB4BEA8" modified="2011-09-21" version="1">MAGDFLREFGYDKTKLELVQKCILNHRGSKVMEKQSPEEICVADADSISHFDAVPSLFYLAYVQRKLGIDDGIDFVKNKLNRSCPKLSERGKEIYKDKYEQVISLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K392</accession>
    <name>F7K392_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250270.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00321"/>
    <dbReference type="EnsemblBacteria" id="EGN33462">
        <property type="protein sequence ID" value="EGN33462"/>
        <property type="gene ID" value="HMPREF0994_00321"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9TS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102870_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="235" mass="25511" checksum="FA52A69F90D944FC" modified="2011-09-21" version="1">MNILKLELKKTNIKPYFLSAIAVFVCIMGLTYILAWVPHLDSGDKNAAILFSTYQGIAAICNAIALMSFSILASAMGYRYLTKEYCGVGAILLFSYPINRKSVVWAKAAVILLFISTAMFLTEYGGFLIFIGTDSVLQMVNDTLVPGDFMLAFRNALVLVCLADGIALCAIRIGFIKKSNSVTIISAVILSMLLINPVAAINEQFLPVLFLAAAALIGGILLTLNVSHKVKRMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Q6</accession>
    <name>F7K3Q6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250434.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00485"/>
    <dbReference type="EnsemblBacteria" id="EGN48203">
        <property type="protein sequence ID" value="EGN48203"/>
        <property type="gene ID" value="HMPREF0994_00485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.533"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291470_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1082" mass="125732" checksum="C911D16BA386446F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3S5</accession>
    <name>F7K3S5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250453.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00504"/>
    <dbReference type="EnsemblBacteria" id="EGN45508">
        <property type="protein sequence ID" value="EGN45508"/>
        <property type="gene ID" value="HMPREF0994_00504"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.553"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN45508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="271" mass="30508" checksum="2439A6FB90CBE2C3" modified="2011-09-21" version="1">MLKLICSDVDGTLVPDGGHDLNPEYFTQIRHLKKNGILFAAVSGRSYSSLKKLFAPVIDDILFICDNGARTIYHGNLLSCYTIRRELAMEIVREIEALPGCTTYISAVKDGYVKEGADELYRWLTEGYQLDIKKLKRMPEDLPANDGILSVEMYHPTRAEEIAHQGLYQKWHGHKELQLVCAGKQWMNFTPINADKGIALSEFQNRYGITPGETMAFGDNMNDASMLLRADQSYAIGNARKEIKSLTRFVADTNINDGVLQVLRTVKTNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Z3</accession>
    <name>F7K3Z3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250521.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00572"/>
    <dbReference type="EnsemblBacteria" id="EGN44760">
        <property type="protein sequence ID" value="EGN44760"/>
        <property type="gene ID" value="HMPREF0994_00572"/>
    </dbReference>
    <dbReference type="GeneID" id="29724639"/>
    <dbReference type="eggNOG" id="ENOG502ZB30">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578394_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="473" mass="53345" checksum="7405D6AB4BAAFE55" modified="2011-09-21" version="1">MSNILKVTSPIGGYENGNNIKMNPTANAEVQGVQAPITPQKVSRPGGRDDAGQNSTQLKLNYESNFNHFIKLLNNSPDQVEDLMRLLMEKKELLVQAGMNKGTAEDIARFFSMIGLKEGNMSAFLKEQADMGIRYRGPFFDLLRQVFNNTDSVDLKAGLLDFVRRYGDMASGGHIMQSISELLEKCREQMFSKSAGELERMAARLKTGEQHVNGDTQKNAALLKEKILPFLNKYISATHDRGLLRQYTAHLAYQLARYENGSMDGLMQAFGKLMGFQGFKKVFGSMDEALIESVLRKASQADEGWNKEFLNILRSGMNGDASTEGKMISQNFVHSMLLNESVYMPVLHLMLPMMVDGRLMYSELWVDPDDKGAAEDDEEDGRVVKALIKFDIEKLGFFDMFFVYKNGKMDMQLDFPDNLKGKEKEIRQNINRIMAENGIRLQNLVTGSSQESIPITEAFPKIYERKNGVNVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K445</accession>
    <name>F7K445_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine-binding chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00636"/>
    <dbReference type="EnsemblBacteria" id="EGN44824">
        <property type="protein sequence ID" value="EGN44824"/>
        <property type="gene ID" value="HMPREF0994_00636"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.689"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="173" mass="19469" checksum="63E22046CC26236B" modified="2011-09-21" version="1">MEMDGTEKLMNEEAALSEELGSKYLTYFTDGQLFGIPIADVVQIIGMQKITEIPEFPEYAKGIINLRGEIIPVIDVRIRLYKPVIEYSDRTCIIVTDVRGSYFGFVVEQVDEVAEIPDELITQPPRMGNDAAARYLTGVAKVKDKIVLLMDIKKLLGEQEFESLAQTAYQSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4D1</accession>
    <name>F7K4D1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">HMPREF0994_00710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00710"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="EGN44059">
        <property type="protein sequence ID" value="EGN44059"/>
        <property type="gene ID" value="HMPREF0994_00710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.769"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN44059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="217" mass="23787" checksum="5B0974D67FB748ED" modified="2011-09-21" version="1">MQQILFCVLQEQGGEDGGMSTAIPYVIEQTKNGERSYDIMSRLLSDRIIFLGTQVDDVSAELIVAQLLFLESQDPEKDIQLYINSPGGSITAGFAIYDTMQYIKCDVSTVCIGMAASFGAVLLAGGTKGKRMALPNAEIMIHQAAISGNGIQGPASDIKILSDHMQRSNQRVIRILAESTGKTEEELKADTDRDYYMSAAEALEYGMIDQIFDGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4E4</accession>
    <name>F7K4E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250672.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00723"/>
    <dbReference type="EnsemblBacteria" id="EGN44072">
        <property type="protein sequence ID" value="EGN44072"/>
        <property type="gene ID" value="HMPREF0994_00723"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.783"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014870">
        <property type="entry name" value="DUF1793"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032515">
        <property type="entry name" value="DUF4964"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="DUF4965"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="DUF5127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08760">
        <property type="entry name" value="DUF1793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16334">
        <property type="entry name" value="DUF4964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="DUF4965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4964" evidence="2">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5127" evidence="4">
        <location>
            <begin position="75"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5127" evidence="4">
        <location>
            <begin position="203"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4965" evidence="3">
        <location>
            <begin position="275"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1793" evidence="1">
        <location>
            <begin position="483"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="654" mass="73049" checksum="49057ADBA9A83C70" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4F2</accession>
    <name>F7K4F2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00732"/>
    <dbReference type="EnsemblBacteria" id="EGN44081">
        <property type="protein sequence ID" value="EGN44081"/>
        <property type="gene ID" value="HMPREF0994_00732"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.795"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_9_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="9"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="348" mass="39070" checksum="124BB2B7CC25479C" modified="2011-09-21" version="1">MWGLDEMRELLANENYIPQLFEYEEKPLEKGEVRVKCIYGAPKHGTEMTGIKEQPFEEKYYDEEMKIFLQREEKVSSVYSGLGNMWVGTITEVGSDVEAYHAGDQVVGYGNLAQTHTVNAQELLVMPEGMTWKQAMCYDPMQFALSAIRDAKLRLGDTVLISGLGAIGQMAAQAAKAAGASLVAVSDPIEIRRKAALENGADIAFNPLECDMGLELRKLTNGVGVDVVIETSANYKALEQGIRALAYNGSMALAGWFKECHIPIHLGREGHFNQQNIFFSRACSEPNRDYPRWDFDRICKESWKLLGTGKIQCENIVYPIVDFDECDKAYIHYIIEHPDESIKMGVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4U6</accession>
    <name>F7K4U6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RGI_lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00875"/>
    <dbReference type="EnsemblBacteria" id="EGN43184">
        <property type="protein sequence ID" value="EGN43184"/>
        <property type="gene ID" value="HMPREF0994_00875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.953"/>
    <dbReference type="eggNOG" id="COG3401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002616_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10318">
        <property type="entry name" value="RGL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041624">
        <property type="entry name" value="RGI_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034641">
        <property type="entry name" value="RGL11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43118">
        <property type="entry name" value="PTHR43118"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18370">
        <property type="entry name" value="RGI_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGI_lyase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="817" mass="91900" checksum="CC25E540DCF677F4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4W2</accession>
    <name>F7K4W2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250840.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00891"/>
    <dbReference type="EnsemblBacteria" id="EGN43200">
        <property type="protein sequence ID" value="EGN43200"/>
        <property type="gene ID" value="HMPREF0994_00891"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.973"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="118"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="34139" checksum="3F2A9FBB2C655B00" modified="2011-09-21" version="1">MKEKLSKNKSIRPGDKVFDIVNTLLLIFVFIIILYPLYYIVIASFSDPDLVLTGKIFMLPRGFQLESYKRVFGNGEIMDGYVHTIMYAVVGTCINLAVTLTAGYALSRPDLRGRKGFTLFFVFTMFFGGGTVPTYMLVRNLHLLNTFWAMVIPNAMSVWNLILCRNFFESNIPKELLEVSQIDGCRNDYFFFKIVLPLSKALIAVMVLFYAVGHWNSYMQPLLYLSDRSKYPLQLVLKNILISSQPDASLAGMTDRAEMYKQTEMLKYALVVVSSVPMIVLYPFVQKYFVQGVMVGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4W5</accession>
    <name>F7K4W5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250843.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00894"/>
    <dbReference type="EnsemblBacteria" id="EGN43203">
        <property type="protein sequence ID" value="EGN43203"/>
        <property type="gene ID" value="HMPREF0994_00894"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.976"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN43203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="435" mass="50285" checksum="A95DDA831B846A06" modified="2011-09-21" version="1">MYSFNKEEYLKRMQWYVEARFGMFLHWGLYSIPARGEWMRSFEKLTDEEYERYFREFDPVDYDPKKWAKAAKEAGMRYMVLTAKHHDGFCLFDSRYTDFKATNTKCGRDLIKEFVEAVRAEGLKVGLYYSLLDWHHEDYPHFSDGAHPMYHNPAYTDEGREWERYVEYLHNQVRELCTNYGKIDILWFDYSFGEYSGEKWEATKLVNMVRELQPGVIIDNRLEVSGAGLGSLASGNPLPYHGDFVSPEQIIPQEGIRDVNGDPLIWEACFTMNDSWGYNLRDKYFKPAPMLIKKLVECVSKGGNMLLNVGPDAKGNFPEESAVILKEVGKWMEKNKESIYGCGISDMPRPDFGRITQKGNKLYYHIFDNTIGPVPLIGIEKKDVKKIRLISAGAEVPVADNWVSNNYPDITFADLGPNPVLPDPIDTVLEVELIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5B3</accession>
    <name>F7K5B3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01042"/>
    <dbReference type="EnsemblBacteria" id="EGN43015">
        <property type="protein sequence ID" value="EGN43015"/>
        <property type="gene ID" value="HMPREF0994_01042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN43015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="460" mass="50577" checksum="FBFA58A8E18EA939" modified="2011-09-21" version="1">MKTKPRIRQNKDKLSYMENAPVGQLIWEMSAPSIVGVLAYNAYNLFDTLFISQWAGTAAVGGVSVSFPFFLFLSAVSSTVGSGAASVISRELGRQNMERAAKTAANAFMLFYASALFVTVFGLLFLDELLHMIGVTETLMPYAKQYTGIILIGAVTSTGFSSLIRAEGSSRYAMLIWVIPLSANILLDLLFIFGLKMGVAGAALGTVLSQCISMGMSFYYFFLSGRSRLHIQLKHFRPDKMLLREIVFIGFPSFLQLSGTSFSLIAANRFLRQYGDDLAISVYGLVNKIDVFFRFPVSGLIQGIQPIIGQNYGAGKRNRVREIMKLSGIVTAMYGILICMITAFCSPQLMQVFTADSDVITLGSHVLPPVMAEMLFLGMQSLLTCYFQATGRKAVSFLLVFCNQFLCFIPAAWILAVLFGLSGIWYAFPVSAAVSLGITVCISLWAQPLYGKFRQMHHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5C2</accession>
    <name>F7K5C2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251000.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01051"/>
    <dbReference type="EnsemblBacteria" id="EGN43024">
        <property type="protein sequence ID" value="EGN43024"/>
        <property type="gene ID" value="HMPREF0994_01051"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1151"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_29_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="215" mass="24673" checksum="22F90F9DC529124A" modified="2011-09-21" version="1">MARNKYPEITEARILDTATKLFLEKGWEETTVQDIVDELGDITRGAFYHHFKSKDDIIDAVTTRMFLGNNPFKAVEENKSLNGLQKIQYVLKFSLQRPDTLQFSQVASSVLQSPIYIGKQVLDSINSMAPFFTQYIIEGINDGSIHVKNPKQTAETMILLLNIWLSPLIFPDTKEDYMEKYEHLKLMYEGIGLPVFDDEMQMLVEKLYDGVAAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5U2</accession>
    <name>F7K5U2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase F(0) sector subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0994_01221</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251170.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01221"/>
    <dbReference type="EnsemblBacteria" id="EGN42547">
        <property type="protein sequence ID" value="EGN42547"/>
        <property type="gene ID" value="HMPREF0994_01221"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1334"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="13">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN42547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="14583" checksum="037A357A956784A6" modified="2011-09-21" version="1">MAKVLLFTALILSIVVPFRLYFKGERTKKRYKVSLAVNAIAFFGLMLGTGLVMFGGQASAADAANTAAAATAAAGGMATGLGYLAAGLSIGLSCVGGGIAVASAASAALGAISEDSSILGKSLIFVGLAEGVCLYGLIIAFMILGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K677</accession>
    <name>F7K677_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42223.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359988.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01361"/>
    <dbReference type="EnsemblBacteria" id="EGN42223">
        <property type="protein sequence ID" value="EGN42223"/>
        <property type="gene ID" value="HMPREF0994_01361"/>
    </dbReference>
    <dbReference type="GeneID" id="29724787"/>
    <dbReference type="eggNOG" id="ENOG5033R8C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527639_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42223.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="539" mass="61119" checksum="BFDB2928C1BAC7D8" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Y1</accession>
    <name>F7K6Y1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HPr kinase/phosphorylase</fullName>
            <shortName evidence="10">HPrK/P</shortName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
            <ecNumber evidence="10">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hprK</name>
        <name evidence="13" type="ORF">HMPREF0994_01648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the HPrK/P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EC" id="2.7.4.-" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251561.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01648"/>
    <dbReference type="EnsemblBacteria" id="EGN42122">
        <property type="protein sequence ID" value="EGN42122"/>
        <property type="gene ID" value="HMPREF0994_01648"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1800"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052030_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="12">
        <location>
            <begin position="132"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="10">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="10">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN42122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="315" mass="35916" checksum="1CC9695E59847024" modified="2011-09-21" version="1">MSHVNLTQIIEKMKLENLTPEIDVKGIKITQPDINRPALQMAGYFEHYEATRLQIIGFVEYTYMESMTEERKQKIYNQLLSYPIPCIVFSRELHPDPLFLQIAKEKNVPILMTKKATSAFMAEIIRWLNVMLAPCISVHGVLVDVYGEGVLITGESGIGKSEAALELIKRGHRLVSDDVVEIRKVSDDTLIGNAPDITKHFIELRGIGIIDVKTLFGVSSVKDTQSIDLVIRLEDWNKDKEYDRLGLEEEYTDYLGNKVVCHNIPIRPGRNLAIICESAAVNHRQKKMGYNAAQELYTRVQNSLARRREEDEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7B8</accession>
    <name>F7K7B8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251660.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01747"/>
    <dbReference type="EnsemblBacteria" id="EGN41560">
        <property type="protein sequence ID" value="EGN41560"/>
        <property type="gene ID" value="HMPREF0994_01747"/>
    </dbReference>
    <dbReference type="GeneID" id="29727955"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="588" mass="68263" checksum="1869B7510BB2845E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7C2</accession>
    <name>F7K7C2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251664.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01751"/>
    <dbReference type="EnsemblBacteria" id="EGN41564">
        <property type="protein sequence ID" value="EGN41564"/>
        <property type="gene ID" value="HMPREF0994_01751"/>
    </dbReference>
    <dbReference type="GeneID" id="29727411"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1912"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="33387" checksum="FB0B4136670CD3B9" modified="2011-09-21" version="1">MKKKKVWDYLWDMLFILPAFVLFFAVIWYPLIKSILYSFTNYDGMSKSFDFVGLTNYMKIFSSKYIKAGIGNTLKFAVVNCLLCNIFQLLLALVLDKKLILKRYLRVAFYVPVLLCTVVVSVVFGHIMQYNGILNTFFREAGLGKFVIDWFGNETAAFIMVCVVNIWQWLGYGAIIYLGGLQTIPENLYEAAKIDGARPFQIFRKITFPLLMPSVTILTFLNLTGGLKLFDLPYTLTAGAPNDATETVSMVIYRMAFKERKMGYASAVSVVFLLVIAVVSIVQVVATRKKEVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7D8</accession>
    <name>F7K7D8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251680.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01767"/>
    <dbReference type="EnsemblBacteria" id="EGN41580">
        <property type="protein sequence ID" value="EGN41580"/>
        <property type="gene ID" value="HMPREF0994_01767"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1928"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="187"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="394" mass="43895" checksum="E97F51CAE3242808" modified="2011-09-21" version="1">MSGHKNTGILISFVLAVGLLSASFTAVFMASHYNRAQFQLLNGICRSIIEELPEAETVIPAILKEYKNKTAVPEEKSILAAYGYRQSDFSKGAPNYGIFFAAAGFFFGGGLFLAAFRHMRRKEMLRIKSLTDYLESVNTGGNGLHLREEEDEFSKLQDEIYKTVTFAYQTRDAALTARQNFAENLANIAHQLKTPITAIHLSLQMMDCPSEKENVRQIRRQLERLTHLEEALLLLSRLDAGTLPFEKKEADVFTVLTLAADNLQEVFSHAGVSVDIPEGKPARITADMDWTMEAIMNLLKNCTEHTPAGGVIHCSYEQNPLYTQIIIRDEGEGLAKEDLPHLFERFFRGQNAKGGGIGIGLSLAKEIIESQNGTIHAKNNPDSGACFEIRFYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7F1</accession>
    <name>F7K7F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41593.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360118.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01780"/>
    <dbReference type="EnsemblBacteria" id="EGN41593">
        <property type="protein sequence ID" value="EGN41593"/>
        <property type="gene ID" value="HMPREF0994_01780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841297_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41593.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="330" mass="36645" checksum="1E326F3C126E9F91" modified="2013-09-18" version="2">MRKEWKAFLWKDIRLMASGHFFLLALVSLLLYTCYIQLVYVKTDQAIFPVYLYNPEGTAVTASPEIEAVSSREELEEKCGDAYGVGILMEGGNPSLSLKSSGSRELDAVRGAYALSLLTDEKPEPAEIIGNNDKEMKQRREITCEFLYFELTAVGFLGVAALLFKEKKMGVMKLYAALPVRRPVFLISKLSACLAADLIFTIVFTVLNLGMTASLQVLPAVLVQAGILSGIMALIGFLCALWLSDFKQFSLFYLGLAIFICTPVFLVGQTGVEWKWMEYNPAYRIFAGMKQAYFEGKAGGGLYLFSCLLAWAALFGLSLYAWNSEMKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7U1</accession>
    <name>F7K7U1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251899.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41391">
        <property type="protein sequence ID" value="EGN41391"/>
        <property type="gene ID" value="HMPREF0994_01986"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2182"/>
    <dbReference type="eggNOG" id="COG4708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104115_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031501">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="17228" checksum="1DD9C2ED7986EFCD" modified="2011-09-21" version="1">MQKKNIQFLTQAAMIAAIYVVLTFVANAFGLANYAVQVRFSEALTILPIFTPAGIPGLFIGCLISNILTGCAIPDIIFGSLATLIGAFGTRALKSNRFLAVLPPIAANAIIVPLILKYAYGLEPLWFSFLTVTAGEIISCGVLGLLLAFALNKYRKQIFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8B0</accession>
    <name>F7K8B0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251796.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01883"/>
    <dbReference type="EnsemblBacteria" id="EGN41288">
        <property type="protein sequence ID" value="EGN41288"/>
        <property type="gene ID" value="HMPREF0994_01883"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2064"/>
    <dbReference type="eggNOG" id="ENOG50313SJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124342_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="158" mass="17416" checksum="86A457C98C1F4B86" modified="2011-09-21" version="1">MNTVTIVLLVILVVLIAAVVVLYFLGRKAQKKQAEQQEQIEAYKQTVSMLIIDKKRMKLKDAGLPAAVIEQTPKLLRGSKLPIVKAKVGPQVMTLVCEESIFESVPVKKEVKATVSGIYITAVKGLHGTAIVKPTKKKGWFKRNVEKLQEKAGAKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8I2</accession>
    <name>F7K8I2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15 16">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="6 15 16">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">murD</name>
        <name evidence="19" type="ORF">HMPREF0994_02165</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15 16">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="6 15 16"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41072.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359794.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02165"/>
    <dbReference type="EnsemblBacteria" id="EGN41072">
        <property type="protein sequence ID" value="EGN41072"/>
        <property type="gene ID" value="HMPREF0994_02165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 15 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 15 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="18">
        <location>
            <begin position="113"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="17">
        <location>
            <begin position="311"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="115"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGN41072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="450" mass="49349" checksum="EB2BBA91A55C6AA0" modified="2013-09-18" version="2">MNVEGKKVLVVGTGKSGIAAAALLAKEKAAPVLFDENKDTDAEEVKKKLPDAEIEVITGTLPEGILDELELAVLSPGVPVDTPFVEKFRDKGIPVWGEVELGYAFSKGKVIAITGTNGKTTTTALTGQIMRDYYESVFVVGNIGNPYTLEALNTREDSVTVAEISSFQLETTVDFHPSVSAVLNITPDHLNRHHTMENYAAVKESITKNQTKEDTCVLNYEDPYTRAFGERCPASVIWFSSADKLAEGYYLEGEDIIRSFGGVTEKLLNINEMKLIGTHNVENVMAAIAMSAAYGVPMANIINTVKHFQAVEHRIEYVAEKDGVVYYNDSKGTNPDAAIKGIRAMNRPTILIGGGYDKQNEYDEWVEAFDGKVKLLVLIGQTKEKIAECARKHGLTNIVFADTFEECMEICVKNAVSGDAVLLSPACASWGMFPNYEVRGNMFKEYVNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8K2</accession>
    <name>F7K8K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002593307.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41097">
        <property type="protein sequence ID" value="EGN41097"/>
        <property type="gene ID" value="HMPREF0994_02190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2396"/>
    <dbReference type="eggNOG" id="ENOG5031VPY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140884_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="14710" checksum="251B62C4F0447E5B" modified="2011-09-21" version="1">MKTIFEEMGGTYRQVGYYFIPNITLPDDGEYQIGKYGRMRRSYLKKYRKILYNNYVLEGTLFKHLAEIDQVCNERIENIVSAMAKQEGVTEAFKAADQIEWVRRMNSIRNRAEEIVLHELVYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8W8</accession>
    <name>F7K8W8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02333"/>
    <dbReference type="EnsemblBacteria" id="EGN41240">
        <property type="protein sequence ID" value="EGN41240"/>
        <property type="gene ID" value="HMPREF0994_02333"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2551"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="97"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="614" mass="72537" checksum="FF172B2B09211193" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9D0</accession>
    <name>F7K9D0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252383.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02482"/>
    <dbReference type="EnsemblBacteria" id="EGN40881">
        <property type="protein sequence ID" value="EGN40881"/>
        <property type="gene ID" value="HMPREF0994_02482"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2721"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635914_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024551">
        <property type="entry name" value="AspAT_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12897">
        <property type="entry name" value="Asp_aminotransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="428" mass="47968" checksum="531DEE4B9CB61340" modified="2011-09-21" version="1">MKAYKDRSKEELLTLKNELEAEYKKFQEMGLKLDMSRGKPSAEQLDISMGMMDVLNSSTDLKCREGIDCRNYGVIDGIQEAKELLADLIEVPADKIIIYGNSSLNVMYDTVARSMTHGVMGSTPWCKLDKVKFLCPVPGYDRHFAITEYFGIEMVNVPMTPEGPDMDMVEKLVSEDAAIKGIWCVPKYSNPQGITYSDETVRRFANLKPAAEDFRIYWDNAYNVHHLYEDDQDNILEILSECEKAGNPDMVYKFSSTSKISFPGSGVAAISASYNNLKDIKKQMSIQTIGHDKLNQLRHVRYFKNLDGIKVHMMKHAAIMRPKFEAVLDILEEELGGLEIGSWLKPKGGYFISFDALEGCAKAIVAKAKEAGVVMTGAGATYPYGKDPQDSNIRIAPSFPPMEELIQATRLFVLCVKLVSVDKLLESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9L7</accession>
    <name>F7K9L7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="4" type="ORF">HMPREF0994_02387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252288.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02387"/>
    <dbReference type="EnsemblBacteria" id="EGN40786">
        <property type="protein sequence ID" value="EGN40786"/>
        <property type="gene ID" value="HMPREF0994_02387"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2614"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_9"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="220" mass="24044" checksum="01808619161B764C" modified="2011-09-21" version="1">MDKKEILRHIDHTLLKPYAVWEDIRILCEEAVEYKTASVCIPPCYVERVHDKFDTLNICTVVGFPLGYSVTAAKLAEVEKALKDGANEIDMVVNISDVKNHQYGKVEAEIRALKEACGGHVLKVIIETCYLTGEEKIAMCQAVTKAGADYIKTSTGFGTGGATLEDVKLFREHIEPSVKIKAAGGVKSREDLEMFLEAGCDRIGTSSAVGLLKGEEAGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9M0</accession>
    <name>F7K9M0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, AGZA family, xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252308.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02407"/>
    <dbReference type="EnsemblBacteria" id="EGN40806">
        <property type="protein sequence ID" value="EGN40806"/>
        <property type="gene ID" value="HMPREF0994_02407"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2636"/>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="456" mass="48687" checksum="E0E3F1AB51689F65" modified="2011-09-21" version="1">MLEKFFKLKENRTDVKTEIMAGITTFMTMAYILAVNPSILSAAGMDANAVLIATALAAFVGTAMMALFANYPFALAPGMGLNAYFAYTVVLNMGYSWQIALMAVFVEGLVFIVLSLTNVREAIFNAIPMTLKSAVSVGIGLFIAFIGLQNAKIVVNSDATLLTYQTFKGDTFHSIGIGAILALIGVLVTAILLVRKIKGGILLGIIITWVLGIICELTGIYVPNPDAGMYSVIPSAIVSFDFSSFGHTFGQVFKADFSNIRILDFIVVMFAFLFVDLFDTLGTLIGVASKADMLDKDGKLPRIKGALMADAVATSVGAVFGTSTTTTYVESASGVTEGGRTGLTAITTGILFLLALIFSPLFLTIPSFATAPALIIVGFYMMGAVVKINFDDMAEAIPAFLCIIAMPLAYSISEGIAIGVISWTLLNLLTGKARDKKISILMYVLTVLFILKYIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Z2</accession>
    <name>F7K9Z2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252576.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02675"/>
    <dbReference type="EnsemblBacteria" id="EGN40658">
        <property type="protein sequence ID" value="EGN40658"/>
        <property type="gene ID" value="HMPREF0994_02675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2929"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="167"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="31344" checksum="B942C32990AF3F38" modified="2011-09-21" version="1">MILSSNPRPLQLWKTLSLEVADSGLAQVDNTWNMEKVCSPYSRVYFIPEGSGTLTLRGREIALQEGYVYLIPAGLLYNYRCDSHMEQLYFHVNIIQVNGMDLFFGCEEVYERKVSGQYLERVLALYRSQRMGDSFCLQGILWEELGFFTRMAGVQETRTRIYSEMVEQFFLLAQNPVSAKNHIRSMADRLHVSESTLSKKFRAETGMYPGGYLEQLVIQKACRLLLQEDRSIAQIAEELEFSDQFYFAKYFKRLMQMPPSIYRRKMRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB41</accession>
    <name>F7KB41_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 8 11">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pgk</name>
        <name evidence="13" type="ORF">HMPREF0994_03071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 8 11"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252972.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03071"/>
    <dbReference type="EnsemblBacteria" id="EGN40248">
        <property type="protein sequence ID" value="EGN40248"/>
        <property type="gene ID" value="HMPREF0994_03071"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3356"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN40248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="42368" checksum="25E5CD2F05B5B914" modified="2011-09-21" version="1">MSLNKKSVDDINVKGKRVLCRCDFNVPLKEGKITDENRLVAALPTIKKLIADGGKVILCSHLGKPKGEPKPELSLAPVAARLSELLGQEVKFAADPEVVGPNAKAAVEAMKDGDVILLENTRYRAEETKNGEAFSKELASLCDVFVNDAFGTAHRAHCSNVGVAQLVDTAVVGYLMQKEIDFLGNAVENPVRPFVAILGGAKVADKLNVISNLLEKCDTLIIGGGMAFTFLKAKGYEIGASLVDDEKIEYCKEMMQKAEKLGKSLLLPVDAVVAKAFPSPIDAEIEVEVFAADSIPAERMGLDIGPKTAETYAEAVKTAKTVVWNGPMGVFENPVLAKGTIAVAKALAETDATTIIGGGDSAAAVNQLGYGDKMSHISTGGGASLEFLEGKELPGVAAANDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBR6</accession>
    <name>F7KBR6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03307"/>
    <dbReference type="EnsemblBacteria" id="EGN40137">
        <property type="protein sequence ID" value="EGN40137"/>
        <property type="gene ID" value="HMPREF0994_03307"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3615"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_29_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="214" mass="24644" checksum="293DAAD0EBF7DEBE" modified="2011-09-21" version="1">MASKGRVLEAAASLFIRKGYEETTMQDIMEESGLSKGAIYHHFAGKQEILSTMIADAQMKVNTFFQEMEENAELTVKEKISRIIRYFFDNKNQSMLIRNRWVEKVPYALVDTVRKGNKYIAPRVAGIIRQGNENGEFRCDFPEELAEALLLLLDVWLDPVITDRTADEICRRLEFIFRLLESFGTQLFGLEDMEAMKRMYAGYAAEGDMKNGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBV1</accession>
    <name>F7KBV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253249.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03348"/>
    <dbReference type="EnsemblBacteria" id="EGN40178">
        <property type="protein sequence ID" value="EGN40178"/>
        <property type="gene ID" value="HMPREF0994_03348"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3660"/>
    <dbReference type="eggNOG" id="COG5520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014379_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyco_hydro_30" evidence="5">
        <location>
            <begin position="52"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_30C" evidence="6">
        <location>
            <begin position="421"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="483" mass="55705" checksum="9D26FF8E10E15A5F" modified="2011-09-21" version="1">MEQTIKLYLTQMGNNKKLQEQAGLRFEEDKPGNDGNEGNVLNVYDQVEYQEIMGFGGAFTQASAVNFMALSDSQRREVLEAYFDKEKGIGYNFCRLTINSCDFSTEMYSYDDTPEDYELKDFSIERDKEDVIPMVLAAKEKASDLRLFASPWSPPAWMKTNGKMDKGGFLRRECQDAWARYTARYIKAYEEEGIPIWGVTVQNEAKAEQGWESCHYEAGEERDFVTGYLKPAYEREGLGDKKIFFWDHNKERVVDRSLETLCSNRARAAFDGIAVHWYSGDHFGALDVTHRLFPEKLLIASEQCKGREELPWESGEAYAHDIIGDLNNWVGAWTDWNMLLDENGGPDHWLDEQLHWERITAKRQELGLEINWKDPRFQKLMKEEGIWFGESPILCDHGEKSLHYASSYYYIGHFSRFVKRGAKRIGSSVYTPGLEVCAFRNPDGSKAVVAMNPGEQEKKTILRFHEKIAEYKIPAHSIVTFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC08</accession>
    <name>F7KC08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253288.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03387"/>
    <dbReference type="EnsemblBacteria" id="EGN39894">
        <property type="protein sequence ID" value="EGN39894"/>
        <property type="gene ID" value="HMPREF0994_03387"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3702"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034451_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="43314" checksum="35D1CF75C2814563" modified="2011-09-21" version="1">MAYEYVNPIKQFNFQINRVLTYGDAACSRQEVTESLSSVRTFAQWNQAWLTLAEKAEREKRWLHAAYYYRMAEFFMKADNPQKMQTYLKCIEYFYKGFDSELHLSYRKDEIPFEEGMLNSIVIPASDSKGTVLVCGGYDSFMEEFVLQVGTWAERGYTVILFEGPGQGVCLHQNMYFRYDFEKPVSAVIDFYGLNRCAMIGISWGGYFALRSAAFEKRIAAAVAYDVMDNGFEVMTNIFPAPVSSLIRLAYRKQWAGIINVVTGLLCKKSILADWGLSQGTYITGTKTAYEFYQKLAEHNLNGITGHYTQDILLLAGEKDHYIPLSQFWRLKEKVHSDKSVTSRLFTEAEGGEQHCQTGNHMLAMNTILDWLDDVFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCH9</accession>
    <name>F7KCH9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltodextrin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03561"/>
    <dbReference type="EnsemblBacteria" id="EGN39470">
        <property type="protein sequence ID" value="EGN39470"/>
        <property type="gene ID" value="HMPREF0994_03561"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3891"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_17_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013422063" description="Maltodextrin-binding protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="440" mass="47143" checksum="A4AB0B46ED27B140" modified="2011-09-21" version="1">MKKTLCYLLTGVMAAGLLAGCGQKTQTGTENTQPKDTATGQTEALAQTEEPSQEEASGQQEPGGAVTLTAWHDNDEAMMNALADVVNEALAGDNITLKFEKKSDVSSQIRLYGTDAENGPDMYLFAHDSLGSFAEMGILEPVGNLISAEKEADLIPMTIEAATYKGEQYLMPVYYETVLFMYNKALWEGEVPSTTEELYDYMEAHTDTAAGTYALVNQHSNTYNVAPFINGFGGYVIDKDGNPGLDAQETKDAITYNKKFAMLQADGDYNTVTALFNEGKAAAIIGGPWLVSGIKEAGIDLGIKALTDFTLPDGNPMIPYSGVQCIGVLKYAAENKKEAVEKVLEVLAGTEAGVTLAKGFNCAPANSRAYDDPDVASNEMILAMKKSAEKAVPMPNIPEMSVMWGPAESLLAAVNKSGEDVDTAAEKYQKEALTAIQDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCJ3</accession>
    <name>F7KCJ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253480.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03579"/>
    <dbReference type="EnsemblBacteria" id="EGN39488">
        <property type="protein sequence ID" value="EGN39488"/>
        <property type="gene ID" value="HMPREF0994_03579"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3911"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056925_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="363" mass="41422" checksum="D76257A8CA7E3577" modified="2011-09-21" version="1">MDMDLGTRISELRREKGMTQEQLAKLVGISAPAVSKWETGSSCPDITLLCPLARALDTNVDTLLQFEEELSQERLDEYLNEILEKARTGNREEAEAMLQKQLHTYPSSSALKYNATTVLNFFLMIFPMETSEKKKAWQMQKKQLFEEVRISGNPQYWQGAVSGLAAAAIQEEDFEEAELLLKELPENSTESTLLWMQLYLKKKEPEKALEVTQHRLYVLVRQMLMCLTTLMNGGMITDNEKVLEICEVYHRLEEIFGVGGGVSEGFFVEAYRRMDRPEDALKSLIKMVEASISPMQEPNPLLFSPTIHIEEGQSVTTLEMKQMLLNSILTDDFFAGFLEREELQEAVEKLKQDIRKESAGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCL7</accession>
    <name>F7KCL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03603"/>
    <dbReference type="EnsemblBacteria" id="EGN39512">
        <property type="protein sequence ID" value="EGN39512"/>
        <property type="gene ID" value="HMPREF0994_03603"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3935"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="34310" checksum="D5FDC3F827D7414A" modified="2011-09-21" version="1">MQYTVRKAEKGENGLKQLSPLERAVEYIEEHLNENIGLSDVSRETGYSYYHMTRLFSTVLGESVGRYINRRRLYNASEKLIHSDQRITDIAFDSGFESAEAFSRAFKNVFGSSPVDYRKAGLDLVVNAKREIAPEDVSHIANNISRSPEIVWLEEIKIAGIRGMTSISDNRIPGLWKQFRSLHTEFFGTERTGYSVCETQQAVYTEDGDVLFSVMLGCPADNLEELPPMLSGKTLSSGRYAVFTHRGTLANLFKTYKYIFGTWLSAAEEELDDREDFEVYEREVTAFDDPDNEVKIYIPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCL8</accession>
    <name>F7KCL8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253505.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03604"/>
    <dbReference type="EnsemblBacteria" id="EGN39513">
        <property type="protein sequence ID" value="EGN39513"/>
        <property type="gene ID" value="HMPREF0994_03604"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3936"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="435"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="478"/>
            <end position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="749" mass="81991" checksum="09D6AF1C310218C5" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCZ5</accession>
    <name>F7KCZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03724"/>
    <dbReference type="EnsemblBacteria" id="EGN38888">
        <property type="protein sequence ID" value="EGN38888"/>
        <property type="gene ID" value="HMPREF0994_03724"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4064"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="384"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="585" mass="66559" checksum="EB2FBEEA9E0E59C0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDJ0</accession>
    <name>F7KDJ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253836.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03935"/>
    <dbReference type="EnsemblBacteria" id="EGN38700">
        <property type="protein sequence ID" value="EGN38700"/>
        <property type="gene ID" value="HMPREF0994_03935"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4285"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="167"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="271" mass="31116" checksum="31DBCAE825174818" modified="2011-09-21" version="1">MKKEFYSEHTLLLTNCGREDCSDLHSWGPGIRPCYIIHYVIKGAGWLEYGKKRFYIQAGQSFLLYPYTVLRYYPDPEQPWEYTWVDFMGENAPELLSNTGFSPACPVSPAISPQQILPLYERLCSLDILYHNKGEACGLLMALLGLYADSFPGSSALNSHREDNRLSTAILLIQTHCHKPEFNVEALCESMHINRVTLYRLFREALYISPNTYISRYRLEQARSLLEMGFSVKNTAFSCGYSDPFYFSRAFKARYGTSPASFKRKDNGTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDJ6</accession>
    <name>F7KDJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="6 7">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the rubredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253842.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03941"/>
    <dbReference type="EnsemblBacteria" id="EGN38706">
        <property type="protein sequence ID" value="EGN38706"/>
        <property type="gene ID" value="HMPREF0994_03941"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4292"/>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128747_3_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN38706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="53" mass="5720" checksum="5639744A0C2C44E2" modified="2011-09-21" version="1">MSKYVCDVCGYIYDPELGDPDNGIEPGTAFEALGDDWVCPLCGVGKDQFSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDK1</accession>
    <name>F7KDK1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253847.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03946"/>
    <dbReference type="EnsemblBacteria" id="EGN38711">
        <property type="protein sequence ID" value="EGN38711"/>
        <property type="gene ID" value="HMPREF0994_03946"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="155"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="28740" checksum="D532678B725F4738" modified="2011-09-21" version="1">MIPIYLCEDNQKELQFLRKTLENYILMESLDFQVVYSATSPYQLLDKLSGNVNGAVYFLDIDLNSEMDGIDLAAKLRQMDSCAYLIFTTTHEEMAMETFRHKVEALDYLLKDSPNYIADVLLCLQHIVKEVRKPHLNKEFRLHFHIPDQELYFYPKEILYVEAIESHCIKLYTKTGIYICRQTLRETANMCPGFLLCHRSFLINPEHIRALQKSSCQIVLDDGSYCPCSFRQIRKLQQYLDNQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDK2</accession>
    <name>F7KDK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253848.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03947"/>
    <dbReference type="EnsemblBacteria" id="EGN38712">
        <property type="protein sequence ID" value="EGN38712"/>
        <property type="gene ID" value="HMPREF0994_03947"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4298"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="335"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="491" mass="57432" checksum="2B89C02A00A8B514" modified="2011-09-21" version="1">MSKRKVLFLMTDSQRADMLGCYGNPDMHTPNLDRLAEQGIRFDKAYTTQPLCQPARAGIFLGCYPHSCASWSNSMGVSGNVQSIGKRLSDHGVHTAYIGKWHLDGGDYFGLGRCPEGWDADYWYDMRNYLEELTPEERVISRRTDSIEKYDIKEEFTFGHRVADRAIDFLKNYNDEDFFCVASFDEPHGPYLCPKKYVDMYADYKLPRPGNFDDTLEDKPEFQRLWARPFRHLTEDPEFRASHKEFFGCNTYVDYEIGRVLEAAEKYAPDAVIIYTSDHGDMLFSHSLTGKGPAPYEENARIPLLIKGFGSRVDENPVSHINLAPAVFEMMGIDIPKAFEGKSLYPELADGSVRVNDHIFVEYGRYEVDHDGFGSFQPMRCIFDGRYKLVINLLDTDEMYDLQEDPDEMVNLIHEERLSQVRNKLHEALIDQMYRTRDPFRSYHWEDRPWHRMERDWDSRHMTRQRENEEYEPRQLDYDTGLEMESAVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDN2</accession>
    <name>F7KDN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253750.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03849"/>
    <dbReference type="EnsemblBacteria" id="EGN38614">
        <property type="protein sequence ID" value="EGN38614"/>
        <property type="gene ID" value="HMPREF0994_03849"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4190"/>
    <dbReference type="eggNOG" id="COG2035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="31385" checksum="15D80ADD9C8AC052" modified="2011-09-21" version="1">MIQEGINGVCMALADSVPGVSGGTIAFIMGFYDHFIASINNVVFGKKEEKAEGLKYLLKLGVGWAAGMIAAVLVLSSLFESKIYLVSSLFIGFILGAIPLIISEEKKNIKIGIKNVLCLLAGIAVVALITYYNSRSESAGMDLSVFSLTEGIKLFLIGMVSISAMFLPGISGSTLLLVFGAYMPVVTAVKEILHFHFSYIPSMLFFGCGVIFGAVSVVRIIKICLEKFRPQTIFVILGMMLGSLYAIVMGPTTLSVPKEALSFSNFNIIACLAGLAIVLGLQKIKERRVSKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDP1</accession>
    <name>F7KDP1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">HMPREF0994_03919</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253820.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03919"/>
    <dbReference type="EnsemblBacteria" id="EGN38684">
        <property type="protein sequence ID" value="EGN38684"/>
        <property type="gene ID" value="HMPREF0994_03919"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4263"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="471"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN38684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="589" mass="66009" checksum="C76A7AFDFDC8B062" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDS7</accession>
    <name>F7KDS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_04006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253907.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04006"/>
    <dbReference type="EnsemblBacteria" id="EGN37695">
        <property type="protein sequence ID" value="EGN37695"/>
        <property type="gene ID" value="HMPREF0994_04006"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4363"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="353"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN37695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="611" mass="68905" checksum="7A3CAEF5CC35FD69" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDY4</accession>
    <name>F7KDY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37099.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360323.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04063"/>
    <dbReference type="EnsemblBacteria" id="EGN37099">
        <property type="protein sequence ID" value="EGN37099"/>
        <property type="gene ID" value="HMPREF0994_04063"/>
    </dbReference>
    <dbReference type="GeneID" id="29729522"/>
    <dbReference type="eggNOG" id="COG2898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031634_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37099.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="537" mass="57987" checksum="8510358BBDAFC609" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE55</accession>
    <name>F7KE55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR04076 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254035.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04134"/>
    <dbReference type="EnsemblBacteria" id="EGN36927">
        <property type="protein sequence ID" value="EGN36927"/>
        <property type="gene ID" value="HMPREF0994_04134"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033H0I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160502_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="111" mass="12885" checksum="138FB3DC1677F3B0" modified="2011-09-21" version="1">MDVRIKVIKTEFYEDIAEEYLSEGKAVGPCPILKEGDTFLYKSSEEAVMPAGFCPWAWVDLYAGISRMSIDRVPREPGKEYWYKHENKSIECCRDGVRPVVFMLERVPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEB8</accession>
    <name>F7KEB8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254098.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04197"/>
    <dbReference type="EnsemblBacteria" id="EGN36477">
        <property type="protein sequence ID" value="EGN36477"/>
        <property type="gene ID" value="HMPREF0994_04197"/>
    </dbReference>
    <dbReference type="GeneID" id="29729646"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4580"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="90"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="327" mass="37118" checksum="EFE23DC6763A015E" modified="2011-09-21" version="1">MHKGYMFSKYALDKDLKDVGGLWSRVDFRDYIITPKKIWLANKWFQAGCFLQRPAKGMRRKRKCIKSADGGKVWVTIYEPVNISKNAPCMVYYHGGAFVLRDRPSTHRLAQVYAESIRCKVVIVHYRLGEPYPIPVKDCYRALVWVAHNAEKLGIDKDRIAVVGDSAGGALAAAVTLLARDRKGPSICFQMLINPVTDRSMSYWSMRQFVDSPGWNANLNRQMWDLYLRSGVFGKPQYAAPMCAPSLENLPPAYVETQEIDCLRDEGNAYADRLAEAGVPVELNEIRGTFNGYDVLFDKNQLVHLSVTRRCLVLKRAFAKMPLTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEH5</accession>
    <name>F7KEH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254161.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04260"/>
    <dbReference type="EnsemblBacteria" id="EGN36540">
        <property type="protein sequence ID" value="EGN36540"/>
        <property type="gene ID" value="HMPREF0994_04260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4654"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="31176" checksum="AB50C4989CA0811A" modified="2011-09-21" version="1">MKKKKRIPKIIVSVILLAGAVICLVPFYWLVRSSFMKIEQIFRMPPEWIPDPFTLENYKQAFTLLPFGQYFLNTIIIVAAVMAGTLLTSSICAYGFSRIEWKGRNLVFSLILSSMMLPYAATLIPTFIGWSKVGAINTYLPLTIPAWFGGGAFNIFLLKQFFQGIPRELDESAVMDGAGHFTIYSRIILPLVKPALVVVALFTFMNTWNDFLAPLIYINDDNKFTLALGLQLFTSQYTAQWHLLMAAATVILIPVVIVFLFGQKYFIEGITMTGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEH9</accession>
    <name>F7KEH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254166.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04265"/>
    <dbReference type="EnsemblBacteria" id="EGN36545">
        <property type="protein sequence ID" value="EGN36545"/>
        <property type="gene ID" value="HMPREF0994_04265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4659"/>
    <dbReference type="eggNOG" id="ENOG5033SAD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810834_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356557" evidence="1">
        <location>
            <begin position="32"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="342" mass="36359" checksum="FCFD7B4DEA50C143" modified="2011-09-21" version="1">MKKCGIAKLCLTLCLILGLTIVPGNRLEVQADEIIATVYGTILSGTTSELLRLSTKQGNMEIKLDSGTDTSACKILLPGKEVSVSVSRGSDAYLHAVKITTDRPTSTATLDSSTTVTVSGTIGDKTTEELIYLKTNQGEMQIKLDPTTNLSGIPFLVLGKTYEITCARGSDAYMHAVTISDKAAATGQLGNNSAYMSVTGTVADSTKETLLYLSTNEGEMQFVIDYSADTSSGMVLTPGRKITVYFYRGTDAYLHAAGLVGEKDSPSSVTLDSAVITVTGTVDGRSDQNMLYLNTPQGVMELKLDTVKNLNNCKVLIRGKNITVNCSRGSDAYLHVTDITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEK2</accession>
    <name>F7KEK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254182.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04281"/>
    <dbReference type="EnsemblBacteria" id="EGN36093">
        <property type="protein sequence ID" value="EGN36093"/>
        <property type="gene ID" value="HMPREF0994_04281"/>
    </dbReference>
    <dbReference type="GeneID" id="29724969"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4676"/>
    <dbReference type="eggNOG" id="ENOG5032R2Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899512_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="33426" checksum="6393F6D6BA18968E" modified="2011-09-21" version="1">MPNCKSKSCKCCSKRYVSCGIDKKGKCLDVCTDPICGDPDCLTVLTPVVYDELGINLCRNIPLELPVTNVDSISVQVMDITFDTTGDTAVTAVPINGRPNCYLITLTNLSVTFYVTLYDCARRVLGTQTVTANYLPADDTSADYDYMDEDTNPTSVELEIFAPYGVAHSDDTGLPAIIHVIGFGEDNTALSQGLNLLAIPKVLNFDPQDSTVTIGLSVILKSVYFSQYKIPHHGKAIVPKACTRPTDDTICLDFVCGDLLDLAIKPLELGPPKYEETLKDACDVPCDPCCNPPTSTPVVPDPDNPEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEM0</accession>
    <name>F7KEM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254200.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04299"/>
    <dbReference type="EnsemblBacteria" id="EGN36111">
        <property type="protein sequence ID" value="EGN36111"/>
        <property type="gene ID" value="HMPREF0994_04299"/>
    </dbReference>
    <dbReference type="GeneID" id="29724229"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060270_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="360" mass="41168" checksum="7E3E4840DD57EDCD" modified="2011-09-21" version="1">MNYTKNWEKSMERYKAFWQGEMLDRCCVSVTAPKRTLEPLPSFTSQEALEHWTDGEWVFKIWKNYFESTYFAGDAFPNLWLNLGPSGHAGYIKDARCKFMQGSGLNCTTWYDHSIYDWDTDFPVFDPNGFLYKKTLELANYLAAESKGEVMVSMPDNAGNLDALACLRGTGELLIDFVEEKETVLRAGKVMQSVWEQAVTDVYQILKDNNQGACSAGWLQVWSPGLMSQMQCDLSVMISENDFNTFAMPELRKQCDFLQFPLYHFDGQEQRRHLQSLLSLEKLRVIQWTSVVGQPSPVEYLPTLQAMQKAGKSIFLMLKPYEIEPIMQGLSSKGLHFSVEAQSVEEADAIVKLVEKLSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEU2</accession>
    <name>F7KEU2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254275.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04374"/>
    <dbReference type="EnsemblBacteria" id="EGN35684">
        <property type="protein sequence ID" value="EGN35684"/>
        <property type="gene ID" value="HMPREF0994_04374"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4773"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN35684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="34934" checksum="1E3BAC890D5BAC09" modified="2011-09-21" version="1">MKIVVLDGYTENPGDLSWEGFEKLGDLTVYDRTVKEEIAARIGDAEAVIVNKTPIDKEVLNSCPQVRYIGVLATGYNVVDIQAARERGIPVCNIPTYGTTAVAQMTFALLLEICHHVAEHSEAVKKGEWTDNKDWCFWKYPLMELAGKKMGIIGFGRIGQAVGKLAKAFGMQVVAYDANQNESGRKIGNYVTLDELLKESDVISLNCPLFPETEGIINKNNISKMKEGVILINTSRGALINEDDLADALRTKKVYAAACDVVSTEPIMPDNPLLGCYNSILTPHIAWAPKESRQRLMDVAVSNLKGFIEGKWINVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFB3</accession>
    <name>F7KFB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04542"/>
    <dbReference type="EnsemblBacteria" id="EGN35311">
        <property type="protein sequence ID" value="EGN35311"/>
        <property type="gene ID" value="HMPREF0994_04542"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="157"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="382" mass="42073" checksum="F3BAE6F24323CFDA" modified="2011-09-21" version="1">MSDAVLSQFTPPEREVKKVYDRKLRFGIIGTGWIAESHVECLKEMEDVEIAAGADLIPGKAEAFFRRYGLEGVHCYPDHKSMMEQEKLDAVCVCTYNTTHAECTIDALEKGIHVILEKPMCVTQKEAEDIIRAEKKSGRVLTLGFQPRLDENMKMIKKIVDSGELGKIYYIQTGGGRRRGIPNSTFIEKSTAGIGALGDIGCYSLDMVLNAVGYPKPLTVSGYTSSYFGPNPKYNNPKDAARFDVDDFAAAFVRLEGDIVLDFRIAWAMHIDTPGDTIIMGTEGALRIPSTECWNGSVGGPMKLYKDVAGAQVEMEIPLCDGEYNSHGVFYSKLRAFIDAIQTGGRAPVPSEQILYNQAIIDAIVRSAALGREVEIQFSDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG13</accession>
    <name>F7KG13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04792"/>
    <dbReference type="EnsemblBacteria" id="EGN34419">
        <property type="protein sequence ID" value="EGN34419"/>
        <property type="gene ID" value="HMPREF0994_04792"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5234"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="34789" checksum="FA91A5B6CAEFEE1A" modified="2011-09-21" version="1">MNRKRSINWRRYLPLYLMLLPGGIYLIINNYLPMAGTVVAFKKYNFQKGIFGSEWNGLKNFIFLFKTKDAWIITRNTICYNLAFIILGTAAAITVAVLLSEIKAVRARKTYQTLILLPFLVSIVVVSYIVYGFLSTEYGFVNHTLQNMGKDKISWYSNPAWWPLILILVNLWKNIGYNCVLYYATLMGIDSSYYEAAVVDGASRWQRIRYITLPALAPTICILTLMSVSKIFYSDFGLFYQVPMNSGPLIDVTNTIDTYVYRGLMETNNIGMSAAAGLYQSLVGFLLVMLANWAVRRQNEESALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG99</accession>
    <name>F7KG99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate diacid regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254788.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04887"/>
    <dbReference type="EnsemblBacteria" id="EGN34514">
        <property type="protein sequence ID" value="EGN34514"/>
        <property type="gene ID" value="HMPREF0994_04887"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5331"/>
    <dbReference type="eggNOG" id="COG3835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058212_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="293"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="362" mass="41267" checksum="4BEDC02A65CCDB13" modified="2011-09-21" version="1">MISNQVIQNSIDELRAITKVDLGVFDVEGLKVATTVDEIDISRDIIENFASSPADSQVVGGRHLLKILDDGEPAYILVAQGPSDDVYMVGKIAVSSIQNLIVAYKERFDRNNFFQNLLLDNLLLVDIYNRAQKLHIEVECPRIIYLIETKIEKDNSAMEMLKSLFSSQNGDYITAVDEKNIILIKALEREDDLDTIEKTADMIVDMMNSEAMMNVRVAYGTVVSELREVSKSYKEATMAMDVGKIFYAEKCVISYAKLGIGRLIYQLPVNLCKIFIEEIFGDNVPYDMDEETLTTINKFFENNLNVSETSRQLFIHRNTLVYRIEKLQKSTGLDIRVFDDALTFKIALMVVNYMKYLESIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGI2</accession>
    <name>F7KGI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, subunit gamma and tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254862.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04961"/>
    <dbReference type="EnsemblBacteria" id="EGN34130">
        <property type="protein sequence ID" value="EGN34130"/>
        <property type="gene ID" value="HMPREF0994_04961"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5417"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="329" mass="37246" checksum="7974B04B0D6437ED" modified="2011-09-21" version="1">MAGFQDIYGQEAMKEHLQNAIKTGKVSHAYIMNGERSSGKEFIARIFAKTLQCEKGGTDACGECHSCKQADSNNQPDIIRVTHEKPNSIGVEDIRSQVNNDMAIKPYSSPYKIYIINEGEKMTVQAQNALLKTLEEPPAYGVLLILTTNVEALLPTIVSRCVVLNMKPVRDDIVRKFLMEDMQIPDYKANVCVAFARGNIGRAKLLASSEDFDNVKEEAVTLLKYIHDMEISEIVAAIKKISEYKLDVTDYLDILSIWYRDVLLFKATNDANHLIFKEEIKYIRKEADQKSYEGIEIILDSLEKAKSRLSANVNFDLTMELLFLTMKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGJ7</accession>
    <name>F7KGJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254877.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04976"/>
    <dbReference type="EnsemblBacteria" id="EGN33771">
        <property type="protein sequence ID" value="EGN33771"/>
        <property type="gene ID" value="HMPREF0994_04976"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5435"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484711_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="390"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="561" mass="60690" checksum="0C4C899BAEFF58CB" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGR3</accession>
    <name>F7KGR3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-aminoethylphosphonate--pyruvate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-aminoethylphosphonate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">AEP transaminase</fullName>
            <shortName evidence="3">AEPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phnW</name>
        <name evidence="6" type="ORF">HMPREF0994_05042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in phosphonate degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:17021"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57418"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58383"/>
            <dbReference type="EC" id="2.6.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.37" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254943.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05042"/>
    <dbReference type="EnsemblBacteria" id="EGN33751">
        <property type="protein sequence ID" value="EGN33751"/>
        <property type="gene ID" value="HMPREF0994_05042"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5508"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047304">
        <property type="term" value="F:2-aminoethylphosphonate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01376">
        <property type="entry name" value="PhnW_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012703">
        <property type="entry name" value="NH2EtPonate_pyrv_transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03301">
        <property type="entry name" value="PhnW-AepZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02326">
        <property type="entry name" value="transamin_PhnW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="2 3 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="33"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="368" mass="41361" checksum="88F2F337B9899F15" modified="2011-09-21" version="1">MNHYKLLTPGPLTTTDTVKQEMLFDHCTWDDDYKKITQEIRAKLLTLAGVSDKDYTVVLMQGSGTFGVESVLTSVIGREDKLLIASNGAYGERMGDIAEHASISRLIYKQDYDKVPDPEVIGMLLEENPDITHVSMVHSETTSGILNDIAAVASVVKKAGKTFIVDAMSSFGGVDIPVGELGIDFLISSANKCIQGVPGFSFIIANREKLMESQGKARSLSLDLYDQWETMEKDGKWRFTSPTHVVLAFARALEEMEAEGGIEARNRRYTDNNRLLIRRMKEMGISPYIGEEYQGPIITTFFYPENHSFTFSEMYEYIKERGYAIYPGKVTEAETFRIGNIGEIYEEDINKLCDILGEFLQTKEKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGT0</accession>
    <name>F7KGT0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254960.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05059"/>
    <dbReference type="EnsemblBacteria" id="EGN33337">
        <property type="protein sequence ID" value="EGN33337"/>
        <property type="gene ID" value="HMPREF0994_05059"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5526"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="123"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="220" mass="24713" checksum="2F7EFBAA416ABF72" modified="2011-09-21" version="1">MTVRTIYLEELNSLRKSVAEMGEAVEASFDMLLTAVDSKDEELEMQIIRGDRVINDMERSIESKCLSLITRQQPIAGDLRMISAALKVVTDIERIGDQTADIAELLLRLKGCDLDAYSRHITGMLQVSKEIVHDAVHAFVTRSSDAANEVIRHDDVVDSLFAKVKDDLVYMLQEGVDNIDACVDVLMIAKYLERIGDHAVNIAEWEIFQESGSIKDIRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGX9</accession>
    <name>F7KGX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255009.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05108"/>
    <dbReference type="EnsemblBacteria" id="EGN33141">
        <property type="protein sequence ID" value="EGN33141"/>
        <property type="gene ID" value="HMPREF0994_05108"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5583"/>
    <dbReference type="eggNOG" id="COG3478">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188846_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018652">
        <property type="entry name" value="DUF2082_NA-bd_Znr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09855">
        <property type="entry name" value="zinc_ribbon_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="70" mass="8001" checksum="BEF104FA27F3F21B" modified="2011-09-21" version="1">MEKKQYICPKCGCQQYESDQFQATGGNFAKIFDVQNKKFITISCRQCGYTELYKGQGSDGWDILDFLIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH81</accession>
    <name>F7KH81_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nanE</name>
        <name evidence="7" type="ORF">HMPREF0994_05219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255094.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05219"/>
    <dbReference type="EnsemblBacteria" id="EGN33252">
        <property type="protein sequence ID" value="EGN33252"/>
        <property type="gene ID" value="HMPREF0994_05219"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5699"/>
    <dbReference type="eggNOG" id="COG3010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086300_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="231" mass="24568" checksum="508B085CFD4FBBFB" modified="2011-09-21" version="1">MDKEAIFKQIKGGLIVSCQALEHEPLYTKEGGVMPLMAKAAAQSGAVGIRANTVRDITQIKEAVDLPVIGIIKKDYEGTPMYITVTMKEVDELVACGVDILAVQGTSALRPDGSTAPQFIAAIKEKYPDQLVMADCATLEEGIACAGAGADFVGTTMRGYTPETKGIDDIDFDFIHELSEKCPAKIIAEGHIHYPEQAKKALEAGAFALVVGGAITRPAEITARFVSAIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH83</accession>
    <name>F7KH83_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255097.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05222"/>
    <dbReference type="EnsemblBacteria" id="EGN33255">
        <property type="protein sequence ID" value="EGN33255"/>
        <property type="gene ID" value="HMPREF0994_05222"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5702"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="107"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="34345" checksum="5BC5421888875186" modified="2011-09-21" version="1">MKKEKKLNHPSVYRIISIIIIAILAVLFTFPLYWIITGSFKTNAAINSTTPIWWPQEWTLANYQKLFSRQTAPLFQFTIPFSSLFTGSSDLKLIVSGPSVPAAIRWLINTVVMAVLSMILTCITASMAGYALAKKRFVGRQFLFTMIVCAMALPKQVILVPLLREMSNLDLYNTIWAVVFPIVGWPFGVFLMKQFSEGVPSEMIEAASIDGASEAKTFVRIIVPMIKPGIGALAIFTFINSWNDYFMQLIMLSSTSNLTISLGIAKLQAENATDFGLIMAGAALAAVPIIIVFLIFQKYFTKGIAMGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHC3</accession>
    <name>F7KHC3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002589131.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05262"/>
    <dbReference type="EnsemblBacteria" id="EGN33295">
        <property type="protein sequence ID" value="EGN33295"/>
        <property type="gene ID" value="HMPREF0994_05262"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5748"/>
    <dbReference type="eggNOG" id="ENOG502Z8SX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1203099_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="235" mass="27412" checksum="9551C93CD6250837" modified="2011-09-21" version="1">MNTWNWLLHFLIIFDLVAFGIYFGGDILFTAISKVQKKSKKDDDLDLYDFEIETAPQKRSLCVDSIRMLYSGEIDEFVEKELLPDAAETMNALSEAEKTAVSLLLKAYIGFLSEEATVDEQSFPMVKELLSYTQGSKEDGEKDAIDCLMEDTVSRTHRHREYYNNYQRYQLMQVDKERVIMACNIIINDLIGRLYRYDYRFGYDITLASEHSIAKKLSDNWQNEWEVEDYEAGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHD1</accession>
    <name>F7KHD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255113.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05270"/>
    <dbReference type="EnsemblBacteria" id="EGN33303">
        <property type="protein sequence ID" value="EGN33303"/>
        <property type="gene ID" value="HMPREF0994_05270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5756"/>
    <dbReference type="eggNOG" id="ENOG502Z81B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076354_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045798">
        <property type="entry name" value="TrbL_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19478">
        <property type="entry name" value="TrbL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="31779" checksum="2D0E5C356E711988" modified="2011-09-21" version="1">MDFLLEALTNWLKEMLVGGIMSNLSGMFDSVNQQVADISVQVGQTPQGWNGSIFSMIENLPNSIMVPIAGVILAIVMTVDLIQMIADKNNLHDVDTWMIFKWVFKSAAAILIVTNTWNIVMGVFDMAQSVVAQAAGIIGSDASIDISSVLADMEPRLMEMDLGPLFGLWFQSLFIGITMWALYICIFIVIYGRMIEIYLVTSVAPLPMAAMMGKEWGGMGQNYLRSLLALGFQAFLIIVCVAIYAVLVQNIALEDDIIMAIWSCVGYTVLLCFTLFKTGSLAKSVFQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHG2</accession>
    <name>F7KHG2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255134.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05291"/>
    <dbReference type="EnsemblBacteria" id="EGN33026">
        <property type="protein sequence ID" value="EGN33026"/>
        <property type="gene ID" value="HMPREF0994_05291"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5777"/>
    <dbReference type="eggNOG" id="COG3601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086673_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025720">
        <property type="entry name" value="RibU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38438">
        <property type="entry name" value="PTHR38438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="26285" checksum="A5B497201411CF5F" modified="2011-09-21" version="1">MNNLAATFMENLIFVLEFLGLVAAMVIIAYVVEKLEKKKNGVKERTLTTRKIAMIGVFSAIAAVLHVMDFPIPFAPDFYKLDFSELPALIGAFAFGPVAAVMIEFCKIILKLLFKGTSTAFVGDLANFIIGCTFLLPASIIYLFRKNKKNAVIGCVVGTLVMTIFGTAFNAVYLLPKFAELYGLPLDSIIEMGHVINPAINSVNTLVVFAVAPMNILKGGIVSLVTMLIYKKISPILHNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHI6</accession>
    <name>F7KHI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255158.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05315"/>
    <dbReference type="EnsemblBacteria" id="EGN33050">
        <property type="protein sequence ID" value="EGN33050"/>
        <property type="gene ID" value="HMPREF0994_05315"/>
    </dbReference>
    <dbReference type="GeneID" id="29727785"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064090_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="266" mass="29099" checksum="C3C5F725EA193CD0" modified="2011-09-21" version="1">MISLPLLKRNMSQTWKILLILLAAMTLYTTVIIYMYDPELAHMLNDYQIALPGIMSAVGMTGIAGNLTEFVYIYLYGFIMFVFPIIAIIILGNKLLAHYIDSGSMGVLLATPNSRLKILLTQLLSMLAGITLLIVLITAIGVGTCEGLFPGELDIPLFLKLNAALLLFHLMLGGIAFLPACIFNDSKWYFSIGAGLLVLFFLFQMLGNTGGDMEFFRYLTPFTLFPGKNIVDGDGEVLLKCLGMAGAAIVMYGCGAVCFHKKDLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHN4</accession>
    <name>F7KHN4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255206.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05363"/>
    <dbReference type="EnsemblBacteria" id="EGN32804">
        <property type="protein sequence ID" value="EGN32804"/>
        <property type="gene ID" value="HMPREF0994_05363"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5860"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="31587" checksum="FA2DC135665BD719" modified="2011-09-21" version="1">MVKDIGNKKVKSAATERREQFLKEFFSRKPVWVGFAIIVVMVICAVFAPLIAPYDPYEQDLLNALKAPGGGHLFGTDALGRDLLSRIIYGSRASLSVGLVSTALAGSCGIMLGIISGYLGKWTDSVIMRIMDAMMSIPIIILAMFLGGVLGKGLGNIMLCIGIVMIPGYARLTRGQVLSLKELDFVTAGKIGGATRFKNAVKHILPNCISPNLILMTMNLGNAIMIEAGLSYLGMGINPPTASWGAMVSDGYKCLNSNPNIAIIPGIFLMVTVWSFNICGDALRDALDPKLRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHQ6</accession>
    <name>F7KHQ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; butanoate metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255232.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05389"/>
    <dbReference type="EnsemblBacteria" id="EGN32830">
        <property type="protein sequence ID" value="EGN32830"/>
        <property type="gene ID" value="HMPREF0994_05389"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5892"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_9"/>
    <dbReference type="UniPathway" id="UPA00863"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="5">
        <location>
            <begin position="181"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="279" mass="29752" checksum="DD36A18F27FCD25F" modified="2011-09-21" version="1">MKVGIIGAGTMGSGIAQAFAQTEGYEVFLCDINEEFAANGKNRIAKALEKRVAKGKMEQAAADAILAKITTGVKTICTDCDLVVEAALEVMDIKKQTFKELQDICKKDCIFATNTSSLSITEIGAGLDRPVIGMHFFNPAPVMKLVEVIAGLNTPDCVVEKIKEVSAAIGKTPVQVNEAAGFVVNRILVPMINEAIGIYAEGVASVEDIDTAMKLGANHPMGPLALGDMIGLDIVLAIMEVLESETGDPKYRPHTLLKKMVRGGQLGQKTGKGFYDYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHV9</accession>
    <name>F7KHV9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255291.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05448"/>
    <dbReference type="EnsemblBacteria" id="EGN32889">
        <property type="protein sequence ID" value="EGN32889"/>
        <property type="gene ID" value="HMPREF0994_05448"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5955"/>
    <dbReference type="eggNOG" id="COG4989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_8_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="34144" checksum="999BB876C1337E0C" modified="2011-09-21" version="1">MKKVNLGKTGLQVPAVAVGCMRMNDLSQGEAERFLSGALDMDAVFFDHADIYGAGKCEEMFGKFLQANPGKRDKLFLQSKCSIIPGKMYDCSSENILEAADGILKRLNTDYLDVLLLHRPDALVEPEEVAEAFDKLEAAGKVRYFGVSNHKPSQIQLLKKYVKQDIAANQLQLSIPNSNMITNGMEVNMLTDGAADRDGSVLDFCRLNDITIQTWSPFQYGFFEGVFLGNDKFEELNKLLKELAEKYNTTDTAIAAAWIMRHPAGMQLVAGTMKLSRLQEICRASEIVLTREEWYQIYLAGGHILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHX5</accession>
    <name>F7KHX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255309.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05466"/>
    <dbReference type="EnsemblBacteria" id="EGN32907">
        <property type="protein sequence ID" value="EGN32907"/>
        <property type="gene ID" value="HMPREF0994_05466"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5975"/>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037108_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="5">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="300"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="375" mass="41427" checksum="AD93AB8E4E075067" modified="2011-09-21" version="1">MAIIDVVKFDGLRSRDWLVYKFPSDTLVFGTRLIVNEGQVAVFVKGGQVCDLFYPGSYILDTDNLPVLFHIFNLPYGGNTPFTAEVYFINTKTKLDIPWGTSDPIQLIDPKYFVKLRIRAFGQMGLKLMDYSLFFRELIGSMNQNDIVSFDKIKLFYRGMVVTKVKSIISEMILAEKISALEISAHLDDISDKCREEISGEFQKYGFNVVNFFVQSINFPDDDFAKINKILEDKAAFEIMGDGRYVTKRSFDVYEGAANNNNGVAGAFAAGGIGAGVGMNVAQAAGGMAPRINPGQMVICPKCGEKSVQGSKFCNTCGAKLEVEKKRCPSCGKENDGDAKFCDECGFSLLERVCECGAKLPAGAKFCYECGRKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHZ3</accession>
    <name>F7KHZ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,3-diaminopropionate biosynthesis protein SbnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571055.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05492"/>
    <dbReference type="EnsemblBacteria" id="EGN32933">
        <property type="protein sequence ID" value="EGN32933"/>
        <property type="gene ID" value="HMPREF0994_05492"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6006"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="376" mass="40263" checksum="1FCD5063BA751B9C" modified="2011-09-21" version="1">MHLLETIGNTPLIELRNTTASTEGRLLFKYERGNPGGSIKDRPALFIVTEAEKRGLLKPGGTIIESSSGNFGISLAMIGAAKGYRVIILVDPKTTATNLALLKCFGAEVIVVTEQDDSGSYHKTRISLANKLASEIPDAFRPDQCFNLLNSTAHYQGTAREIFADCPDNVAAIVAAVSTGGQLGGISRYTKTYRPDVKVIGVDAVGSSIFGGESHSYLIPGIGLAWTPCNVAVENIDSVYKVTDEAAFVAARCFARNEGVLMGPSGGACALVALTITKQLSPHDCVVCIISDGGDRYIQTLLDDAWMQSNNFSIETSLEKLLALTGTITPWSIHPDQNANYKPELKSQLCVPASTQTINENIDEINESASRISFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI72</accession>
    <name>F7KI72_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255358.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05551"/>
    <dbReference type="EnsemblBacteria" id="EGN32376">
        <property type="protein sequence ID" value="EGN32376"/>
        <property type="gene ID" value="HMPREF0994_05551"/>
    </dbReference>
    <dbReference type="GeneID" id="29728305"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364069" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="381"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="521" mass="58178" checksum="33978353E6579E46" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI88</accession>
    <name>F7KI88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255374.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05567"/>
    <dbReference type="ESTHER" id="9firm-f7ki88">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN32392">
        <property type="protein sequence ID" value="EGN32392"/>
        <property type="gene ID" value="HMPREF0994_05567"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6083"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="526" mass="58783" checksum="9B524FA8789127D9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KID0</accession>
    <name>F7KID0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05609"/>
    <dbReference type="EnsemblBacteria" id="EGN32320">
        <property type="protein sequence ID" value="EGN32320"/>
        <property type="gene ID" value="HMPREF0994_05609"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6127"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="6">
        <location>
            <begin position="165"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="5">
        <location>
            <begin position="301"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="585"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="708" mass="79888" checksum="289B2B8F97DC3E35" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KII3</accession>
    <name>F7KII3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255469.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05662"/>
    <dbReference type="EnsemblBacteria" id="EGN32286">
        <property type="protein sequence ID" value="EGN32286"/>
        <property type="gene ID" value="HMPREF0994_05662"/>
    </dbReference>
    <dbReference type="GeneID" id="29728830"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050999_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="433" mass="49497" checksum="7C19D0CE3337B2AC" modified="2011-09-21" version="1">MKYKIKQGMIFGILFLILAGAMLILAEAFKNVITAERMAAARTVEAGFNRGLDETFGNLNHAVKLSYAIDFEDTGSLTLFHKKVQDLMDENEHISYVAYFKEDTLDYIYPADKFRSLIGKNMADFTYSITLAKVVKTPVVEGPANLLDENGDVFLFIQPLYNGTYFIGEIVVAMDSGYVLSSLGLNELENGNYDYELWRVDFLGHSKTVIATSDTTVDYSDAVKHEFSLPATWNISILPKGGWITPSEDVFINTVFLSFGLVLLGILILLYRILRLQKKLQIAKYTNADSGLFTMEGFLLFTNNRLTKNPDSHLCILELQLGNFRRFTKNMDREELVTYLMQLRQNITDCFPDDTVAARINDDSFILAIFMDGQQLERSIEDFILQLYWKRKIDDQKIFITPRYRTVTYPKDGRDALSLVKAVIRQFETKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIM0</accession>
    <name>F7KIM0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255506.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05699"/>
    <dbReference type="EnsemblBacteria" id="EGN32188">
        <property type="protein sequence ID" value="EGN32188"/>
        <property type="gene ID" value="HMPREF0994_05699"/>
    </dbReference>
    <dbReference type="GeneID" id="29728754"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344785_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="379"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN32188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="820" mass="94691" checksum="8821CED23ECA785E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIY8</accession>
    <name>F7KIY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255593.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05817"/>
    <dbReference type="EnsemblBacteria" id="EGN31893">
        <property type="protein sequence ID" value="EGN31893"/>
        <property type="gene ID" value="HMPREF0994_05817"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6363"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067512_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="346" mass="38296" checksum="A72C85FDC9EA86D6" modified="2011-09-21" version="1">MDSLTARPNILKQANLSLIRRAIKAKGTSTRAEIAIETRISSTTVRSLLSEMLENGEIESIGLDESSGGRKAQRYRLNPEFCYGAAFCLFEDHVVFLLVNIYGEIAEKEELKIQDGNVRQTLLSFLDELIGKKEIKSIGLGVPGIVENGCYWKKSKEDGNMYKSDIGIFLSERYQLPVIMENDINATAIGFGRCYAKEFPEENPEDTNMAFLHFEEHCVSAGFISAGRIIRGCGNYAGELGLLPVDADRLLDECMTDPMDDVQYVNLMIKILSWVCGILNPAYIALGGPALRPDCIGAVSDGLSALLPGHMAAEILYSPDVRHDYYDGLASLTAGRIFEEIQFIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJB3</accession>
    <name>F7KJB3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255731.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05955"/>
    <dbReference type="EnsemblBacteria" id="EGN31583">
        <property type="protein sequence ID" value="EGN31583"/>
        <property type="gene ID" value="HMPREF0994_05955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076570_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="194"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="315" mass="35806" checksum="F90FA5063F87B803" modified="2011-09-21" version="1">MKENAAYNEQFVGECLKKIRKAPDAEEGLNQLLRFLGERLECDRVYVFEEMDRQHIHNTYEWCRSHVSSGIQELPYVAKKDLYPWYERLADGENIIEPDVESLLKSDPLIYEFLQRQNIRSVILSPMMAQGKIHGFLGADNPPPEKMEHISILFEVLAYFVCSLVGQRDLLMLRRLRADRQKPNPELSGHNGKTILLVDDSRELLYLNERILRLQGHTILSAGTLREAGKVLEEVTPDVIVLDIDLPDGSGLAFCRERCSRADIPVVFLTAHSDAQTAKEGMEAGGFAFLTKPYDVEELQRAVTDAMDRKAGVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJB8</accession>
    <name>F7KJB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255736.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05960"/>
    <dbReference type="EnsemblBacteria" id="EGN31588">
        <property type="protein sequence ID" value="EGN31588"/>
        <property type="gene ID" value="HMPREF0994_05960"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103067_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="187" mass="21218" checksum="28AF6BBD3992D320" modified="2011-09-21" version="1">MDKTHGIIIFGANGSGKTTLGRELAGLLGFRHMDIEDYYFEKSEIPYTVKRSRKDCLELMLFDIEKYGSFVITAVTGDFGDEIQRLYKLAVGITAPHEVRMSRIKQRSREKYGERVCKGGDMYEQEQQFFDFAAARSLSGIGEWAETLTCPVMYVDGMVDFHINAAAIAERFSALIKDRDEMGSIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJK0</accession>
    <name>F7KJK0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="10" type="ORF">HMPREF0994_06034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255810.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06034"/>
    <dbReference type="EnsemblBacteria" id="EGN31388">
        <property type="protein sequence ID" value="EGN31388"/>
        <property type="gene ID" value="HMPREF0994_06034"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6605"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="9">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="9">
        <location>
            <begin position="154"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN31388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="256" mass="28536" checksum="5A729B88F90E2D87" modified="2011-09-21" version="1">MRNFKIVLQYEGTRYKGWQKQGKGEGDSSSSASPENTIQGKLERLLSRIAGKPVEIQGSGRTDAGVHAYGQVANFHMDTDDTSEALMEKINSYLPEDIGVISVEEVPERFHSRLNAKSKTYRYRVLNSAVPHIFERRYVYQVPEHLDMEAMRRAAILLTGSHDFKAFTSAKKGKKSTVRTVDSIQIDRVGEEIHFTFSGNGFLYHMVRILMGTLLEVGTGAKKPEDMTAILESGSRECAGPLVPACGLALMEVRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJL8</accession>
    <name>F7KJL8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TelA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255828.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06052"/>
    <dbReference type="EnsemblBacteria" id="EGN31406">
        <property type="protein sequence ID" value="EGN31406"/>
        <property type="gene ID" value="HMPREF0994_06052"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6625"/>
    <dbReference type="eggNOG" id="COG3853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032111_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026508">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR026508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="382" mass="42800" checksum="10E1BD9E53F1B3A1" modified="2011-09-21" version="1">MSEEFKDFTATPTLTLNPVAEESAVPAMAQETRVQPNEAGWDDSMLSAEEKQMVVDFSKQIDLKNSNLIMQYGAGAQKKMADFSEKALDNVKTQDLGEVGDLLSGVVSELKSFDAEEERGVFGFFKKSANKITAMKAKYAKAETNINKICQVLEGHQVQLMKDAATLDKMYELNKTYFKELSMYILAGKKKLKEVREGELAQITAKAQQSGLPEDAQEARDLDSMCNRFEKKLHDLELTRMISIQTAPQIRLVQNNDTLMVEKIQSTIVNTVPLWKSQMVLALGVEHSTQAAAAQRQVTDMTNELLRKNAATLKTATIETAKESERGIVDMETLKITNESLISTLDEVMRIQQEGRQKRQEAEVEMARMESELKTKLLQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJN5</accession>
    <name>F7KJN5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06071"/>
    <dbReference type="EnsemblBacteria" id="EGN31425">
        <property type="protein sequence ID" value="EGN31425"/>
        <property type="gene ID" value="HMPREF0994_06071"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6650"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="273" mass="31461" checksum="E78DE3DD20302070" modified="2011-09-21" version="1">MEHIITFLPGQLPGEEVFGIEMTGITYPDSHYHIVRENSLIYCLEYVMEGTGVVQIGEEIYHPEKGDVYLLASGKYQDYRADPRHPWQKIWMNVRGTLCDTLVDGYGLRDVVLFKNCSIYPLFREFVQLCEKKEGSKTELAKRTSLLFHEILLNLAAHEAAGGSQEKPLPETAVHIRKYVDEHIYEKLTIRQLSEAASLSPSQLTRVFRRAYGQTPYEYILSRKVDTACLLLRNTGLTVKEIAYRLQFSDEHYFSNLFRQRTGSPPGKYKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJZ8</accession>
    <name>F7KJZ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255963.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06187"/>
    <dbReference type="EnsemblBacteria" id="EGN30680">
        <property type="protein sequence ID" value="EGN30680"/>
        <property type="gene ID" value="HMPREF0994_06187"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6775"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428089_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="641" mass="74146" checksum="4D60AC4A1BBC2F72" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK40</accession>
    <name>F7KK40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_06143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255919.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06143"/>
    <dbReference type="EnsemblBacteria" id="EGN30636">
        <property type="protein sequence ID" value="EGN30636"/>
        <property type="gene ID" value="HMPREF0994_06143"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6729"/>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064906_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN30636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="22920" checksum="1783E532AEB60246" modified="2011-09-21" version="1">MELQPSVIFAIEIIGTIAFASSGAMVAVRKKLDLFGIIVLGVITAVGGGMLRDILIGNIPPNMFRNPVYVLAAFLTVLVLFMLFRFWPSLLGSRYMESYERIMNILDAIGLGAFTVIGIDTGVEAGYGNYHFLIIFLGVITGIGGGILRDIMAGETPYVLKKHIYACASIAGACLYAGLLEVSNSDSAMIVSALLVVAIRILASHFRWDLPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK52</accession>
    <name>F7KK52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256007.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06231"/>
    <dbReference type="EnsemblBacteria" id="EGN30500">
        <property type="protein sequence ID" value="EGN30500"/>
        <property type="gene ID" value="HMPREF0994_06231"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6827"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN30500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="179" mass="20177" checksum="E34BA504EBAB50EB" modified="2011-09-21" version="1">MADLKGSKTEKNLETAFAGESMARNKYTYFASKARKDGYVQIANIFEETANNEKEHAKMWFKLLNDGIGSTAECLLAAAEGENYEWTDMYANFAKEAKEEGFTEIARLFEGVAKVEKEHEDRYRKLLANVEGDMVFSKDGDVVWQCSNCGHICIGKKAPEVCPVCAHPQAYFQVKAENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK81</accession>
    <name>F7KK81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256036.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06260"/>
    <dbReference type="EnsemblBacteria" id="EGN30529">
        <property type="protein sequence ID" value="EGN30529"/>
        <property type="gene ID" value="HMPREF0994_06260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060313_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="31758" checksum="88E023CAF0B58EB9" modified="2011-09-21" version="1">MSKGKRIGYGVLSLLPLLFMLLIQVLGGQIIYAAVTVYMSMQPGMDPAMLNDIVYTYVMEHYTGVLVLIQGVTLLVFGFWYYLGFTRKKEKGTVKNLLHIHNLAGIFLLSVGIYFFVTLFLVAADHLVPDIMDEYNMLMEESGIVGLTLLSSIVTLVMAPLGEELIFRGLTLQYLRKTGLGFHAANIIQAILFGIAHMNWIQGIYAFLLGLILGWLCKRFKTLAAPMLLHMFFNFSGTYIAALIDPLPENIWLYLFLFAAFAVFTFLGIKVLGKAPLYQENTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK96</accession>
    <name>F7KK96_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cys_rich_VLP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256047.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06275"/>
    <dbReference type="EnsemblBacteria" id="EGN30194">
        <property type="protein sequence ID" value="EGN30194"/>
        <property type="gene ID" value="HMPREF0994_06275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6878"/>
    <dbReference type="eggNOG" id="ENOG502Z9XT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116176_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025973">
        <property type="entry name" value="Cys_rich_VLP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14194">
        <property type="entry name" value="Cys_rich_VLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cys_rich_VLP" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="137" mass="15892" checksum="58DCFF62BB98F7CB" modified="2011-09-21" version="1">MRDNPYKDLPPLERRPDGSLYRMTPAQRKQANALIRRECCCYEDGNCMFLDDGDTCTCPQTVSFSVCCKWFRWAVLPLDKTLEAEIFRDKDLKRCAVCGGVFVPKSNRAKYCPDCAARVHRRQKTESERKRRSTVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB8</accession>
    <name>F7KKB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256067.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06297"/>
    <dbReference type="EnsemblBacteria" id="EGN30216">
        <property type="protein sequence ID" value="EGN30216"/>
        <property type="gene ID" value="HMPREF0994_06297"/>
    </dbReference>
    <dbReference type="GeneID" id="29726973"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6901"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364378_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="760" mass="86230" checksum="B2E04E9F8D4A726A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKJ0</accession>
    <name>F7KKJ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">HMPREF0994_06369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256131.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06369"/>
    <dbReference type="EnsemblBacteria" id="EGN47977">
        <property type="protein sequence ID" value="EGN47977"/>
        <property type="gene ID" value="HMPREF0994_06369"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6971"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="85" mass="10043" checksum="F7C7E77C05A76BE5" modified="2011-09-21" version="1">MEERNLRKTRTGKVVSNKMQKTIVVAVEDHVRHPLYGKIVKRTYKLKAHDENNDCNIGDTVKVMETRPLSKDKRWRLVEIIERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLK8</accession>
    <name>F7KLK8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">HMPREF0994_06746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256499.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06746"/>
    <dbReference type="EnsemblBacteria" id="EGN46670">
        <property type="protein sequence ID" value="EGN46670"/>
        <property type="gene ID" value="HMPREF0994_06746"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7373"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_9"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN46670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="27620" checksum="C98540C578605855" modified="2011-09-21" version="1">MHTKRIIPCLDVHNGRVVKGVNFVNLQDAGDPVEIGEAYDKAGADELVFLDITASSDDRKTVVDMVRKVAEKVFIPFTVGGGIRTVEDFKVLLREGADKISINSSAINRPELISEAADKFGSQCVVVAMDVKRRPDGSGWNIYKNGGRIDMGIDAFFWAEKVTRLGAGEILLTSMDCDGTKAGYDIELTRKIADMVPIPVIASGGAGKLEHFYDALVEGRAEAVLAASLFHYKELEIREVKEYLQGKGVSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRN9</accession>
    <name>S2KRN9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_07263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360239.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07263"/>
    <dbReference type="EnsemblBacteria" id="EPC05114">
        <property type="protein sequence ID" value="EPC05114"/>
        <property type="gene ID" value="HMPREF0994_07263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_9"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="192"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="380"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EPC05114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="577" mass="62396" checksum="780A7FB53A8A2123" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWJ2</accession>
    <name>S2KWJ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359860.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07043"/>
    <dbReference type="EnsemblBacteria" id="EPC05375">
        <property type="protein sequence ID" value="EPC05375"/>
        <property type="gene ID" value="HMPREF0994_07043"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="610" mass="69625" checksum="AEB2975BE85026FD" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>S2LK26</accession>
    <name>S2LK26_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_07073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EPC05278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359907.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07073"/>
    <dbReference type="EnsemblBacteria" id="EPC05278">
        <property type="protein sequence ID" value="EPC05278"/>
        <property type="gene ID" value="HMPREF0994_07073"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009640_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="9">
        <location>
            <begin position="30"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="8">
        <location>
            <begin position="630"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="340"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="450"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EPC05278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="702" mass="80875" checksum="F49F8B7E5EE2C9E1" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2E3</accession>
    <name>F7K2E3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4366 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249971.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00022"/>
    <dbReference type="EnsemblBacteria" id="EGN48255">
        <property type="protein sequence ID" value="EGN48255"/>
        <property type="gene ID" value="HMPREF0994_00022"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.25"/>
    <dbReference type="eggNOG" id="ENOG502Z81G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052621_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025376">
        <property type="entry name" value="DUF4366"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14283">
        <property type="entry name" value="DUF4366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363653" description="DUF4366 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4366" evidence="4">
        <location>
            <begin position="191"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN48255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="389" mass="40638" checksum="EAD8A267698BB042" modified="2011-09-21" version="1">MRTKRISLLVALVFLIGAMTLPMTAFAAGGKDTTPPTLTAVLDGETVKIVSSDDNSGVEAVYIDKTRVNSLVDGKASVALKDYAGTDKKVSVYAVDYAGNRSDAVQFDNPYYKEPVSTEKPAAPTQPSQSSTPATKPVQTQAASSGSTGTQSSSSNTGTDSGGTSSQDGSSGSTGNSGTPEPTTSSVPEGAFTPEGTGTVLDSATGEDGDKQFYTITTEAGNVFYLIIDGKRDDNNVYFLNGVTEADLMALAEKNDGSVSVIPAADVCTCKEKCEAGKVNTGCPVCKNDLNGCIGKEKPAEPEEPAESEQPKKDTGSVGTIIFIIVALLAVGGVGYYVKIVRPKQQAADEDEFDEDDGYGEGFDPDEAYGEPEYLSEDDFEDSTHEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2E5</accession>
    <name>F7K2E5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249973.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00024"/>
    <dbReference type="EnsemblBacteria" id="EGN48257">
        <property type="protein sequence ID" value="EGN48257"/>
        <property type="gene ID" value="HMPREF0994_00024"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.27"/>
    <dbReference type="eggNOG" id="ENOG502ZAM5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1649951_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="160" mass="19234" checksum="E074EB00CF7A8BE2" modified="2011-09-21" version="1">MVNTIVSIPGYVHLYRSLLRFYDMPENEIREMLYLLNTANLDCYEYYHPERELALSGPVAFCHWLETMDCRPYRTEVQLYKSLLFLQRSVDRDLIVTSQREALQTLKCIISNIEYRFYKAYEMEIEDKRTVYGECTYRLVPREDEPSVCLMHDWIYLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2H3</accession>
    <name>F7K2H3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250001.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00052"/>
    <dbReference type="EnsemblBacteria" id="EGN48285">
        <property type="protein sequence ID" value="EGN48285"/>
        <property type="gene ID" value="HMPREF0994_00052"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.54"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117542_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="140" mass="16363" checksum="0C14D2EC27337034" modified="2011-09-21" version="1">MKKINLRDYYPFYTTDTIVEVPDEVADLLHEYKLNEAAYILRTYRHKAYFSLDYDANVERDALVIVLTPADILERKEENARLYQALASLPEKQRNRIYAHYFLGMSKSDIAKAEGTHKSRITRSINAGLRSLEKFLKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V3</accession>
    <name>F7K2V3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_00182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250131.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00182"/>
    <dbReference type="EnsemblBacteria" id="EGN40739">
        <property type="protein sequence ID" value="EGN40739"/>
        <property type="gene ID" value="HMPREF0994_00182"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.194"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="163"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="42519" checksum="B683845A51DDB80C" modified="2011-09-21" version="1">MKKLKLYPKTFFYTLGLLLFIVFMAHALLYFLTPQVPLELSADTSHAETMLTGSINLTPYIKQMILKVLPISLGCCILVSILCSLLFSKQITVPVKHISTVTERMAGMDKTAVCEIHAQDEIGVLADNINDLYQNLLTAIESLEMEKQRVQEAERSRVEFLRAASHELKTPLTALNAVLENMILGIGKYRDYETYLPECKEMTEQLSDMVREILETSKLGSPMKSEAWAETDLSLFLLPLCEPYEQIAKARGLIFRLDLSAGFCAVLPQRIFGKAVSNILANAVAYTKEGGTISLCFRKSDLIIENECTPIPAEALLHVFEPFYRPDYARNREDGGNGLGLYIVDTLLKEMELPYSFQPMEQPAGMRFVISLKGEHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K314</accession>
    <name>F7K314_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250192.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00243"/>
    <dbReference type="EnsemblBacteria" id="EGN37882">
        <property type="protein sequence ID" value="EGN37882"/>
        <property type="gene ID" value="HMPREF0994_00243"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9F4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799072_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="359" mass="42599" checksum="B87AD9F8B5507387" modified="2011-09-21" version="1">MAAAEKSRDENNRKDWEERVIALRMERQHLMKPAGLEEYNVLYRDLSPGLNIYWHGFGEPPCLVYRAGFDDLEYNRERQRNRELVKGRFQKGNIGFIQEEDMELFAGLYRKPWKPDDTQELILALIDREGPLNIGLIKEMTGLLVKQITPALHKLQESFVLFEDQFDGEWDREWYRFEEMFPDVDVQHFTREEALKMVLPRFLFRYVGASVKNFRDFYGIPERELKAAAEELTAGGQFVQKDGIYYLAADFELLQKQERTPFRKILVLHRNDCLVRCEEHHLKQEYKREGMDILQYLLIDGRIRGAVLGHFKYGPYIMEDVCVRLPENEAEARKMEIMEAIYEINGREEPIRRYMGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K338</accession>
    <name>F7K338_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250216.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00267"/>
    <dbReference type="EnsemblBacteria" id="EGN37906">
        <property type="protein sequence ID" value="EGN37906"/>
        <property type="gene ID" value="HMPREF0994_00267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093121_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008811">
        <property type="term" value="F:chloramphenicol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001707">
        <property type="entry name" value="Cmp_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38474">
        <property type="entry name" value="PTHR38474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00302">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000440">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01059">
        <property type="entry name" value="CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000440-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="218" mass="25358" checksum="3CE6397EEECD8AFA" modified="2011-09-21" version="1">MSEFYPIDMQIWPMAQAFHYYTRMAPTSYTVNVNMDVTILRKELKKRGYKFFPTYLYLVTRGISNQQELRIHVKDGVLGYWDNLTPAYPQFHADDRTTSLLWTEYNDKFECFYNDYLIDTKQHGQSHGILSSKGVPPANAYIISCIPWFTFNSFSLHNHGIKNYYVPSFEAGGFAETAGGKIIMPLSVTVHHATTDGYHLKVFFEELQRMMDCPGEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3E2</accession>
    <name>F7K3E2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250324.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00375"/>
    <dbReference type="EnsemblBacteria" id="EGN33516">
        <property type="protein sequence ID" value="EGN33516"/>
        <property type="gene ID" value="HMPREF0994_00375"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076491_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="256" mass="29230" checksum="E2FA88772AC9F03B" modified="2011-09-21" version="1">MFNYMKSEWYRQRNNRGLQNTILVCLGLIILMVAVLAFFGRRPGFAYANTYFAFNGIFTSMSGIFPLTLVFAGFMENNSRNRQSPLKNSVAFGIPRSSIYLGKFLVQLLICTLVYLILPAVLVCLSWLFLEHSNEGEWYYLAHALIGGYPLCVFMLSIGFCFIFNIGNSISGILPILFIVYILPYLFRFLGMKYPIFSEAAEWCPASMIGLSFDNAGIHFYWDTPIRMLRCYLSGLGGALIFLCAGIFWLKKREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3N2</accession>
    <name>F7K3N2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250410.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00461"/>
    <dbReference type="EnsemblBacteria" id="EGN48179">
        <property type="protein sequence ID" value="EGN48179"/>
        <property type="gene ID" value="HMPREF0994_00461"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.506"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068049_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN48179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="28027" checksum="5E5D579D69DF250B" modified="2011-09-21" version="1">MVGIYFSGTGNTRYCVERFLACCGGEAEAVSIEDSRAVEAIRENGVIVFGYPVYFSNMPKIVRDFMEEHQKYFFGKKVFLIATMGLFSGDGTGCSARLFKKYGADIVGGVHLKMPDCIGDERALKRTVRQNHELIEAAGDKIKKAAEGLKGNRPPREGLGFGYHAAGLFGQRLWFYGKTKDYTDRVHVDADKCIGCGKCVSLCPMDNMELRSGKAVQGGRCTMCYRCVNHCPGQAITLLGKKLYEQCTVEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3P1</accession>
    <name>F7K3P1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250419.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00470"/>
    <dbReference type="EnsemblBacteria" id="EGN48188">
        <property type="protein sequence ID" value="EGN48188"/>
        <property type="gene ID" value="HMPREF0994_00470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.518"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN48188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="216" mass="25218" checksum="4AB4E6A2FF0997BB" modified="2011-09-21" version="1">MNILIVEDESDMQKILKLYLQREGYQVNSVSNGRDAIDFLIVNAVDIVLLDWMMPIKNGMETLKEIRQLNIPVKILMLTAKGENADEAAGLTFGADDYLRKPFDIQILLLRIKKLCNSENHLRCNDIVLNPVTMEVMKGQDKVKLTKNEYELLKYFLANQNMILTREQLLNHIWGMDFEGDIRTVDTNIRRLRQKIGEEYIQTRIGMGYIMERRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K419</accession>
    <name>F7K419_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250557.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00608"/>
    <dbReference type="EnsemblBacteria" id="EGN44796">
        <property type="protein sequence ID" value="EGN44796"/>
        <property type="gene ID" value="HMPREF0994_00608"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.661"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="120" mass="13121" checksum="F62BF9846689A9A7" modified="2011-09-21" version="1">MAKILVVDDAAFMRMMVKDALSKGGYTDVYEAEDGARAVEEYEKLSPDLVIMDITMPNMDGLQALKKIKEINPNATVVMCSAMGQESMVIEAIKSGAKDFIVKPFKADRILKTVSSIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K476</accession>
    <name>F7K476_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00667"/>
    <dbReference type="EnsemblBacteria" id="EGN44855">
        <property type="protein sequence ID" value="EGN44855"/>
        <property type="gene ID" value="HMPREF0994_00667"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.723"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="34813" checksum="83F284A98E3E263A" modified="2011-09-21" version="1">MNQKIKKDNKGKTMKRCREDMIFDTIVFILLTVILIVVAYPLYWVIISSISDPSAVSGGRVLWKPVGFTMKGYMEVFKNSAVMKGFLNSIIYTVCGVCINLFVTLPTAYALSRDRFGGKKIVTLFYMVTMFFGGGLIPTYLVIRNLHMLNTMWALVLPGCLSVYNMIVARTFFKSNISEELYEAAEIDGCTQGQFFFRIALPLSAAITAILVLYYGVGHWNSYFSALVYITDAEKYPLQLVLRNILITNETALAQSATTEAARAALREKQELIDVMKYSLIIISSIPVLLLYPFIQKHFVKGVMIGSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4L0</accession>
    <name>F7K4L0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250738.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00789"/>
    <dbReference type="EnsemblBacteria" id="EGN43498">
        <property type="protein sequence ID" value="EGN43498"/>
        <property type="gene ID" value="HMPREF0994_00789"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.857"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="407"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="453" mass="52448" checksum="DB5DE36DA18A0974" modified="2011-09-21" version="1">MEKIRFPKDFIFGTATSAAQLEGAAGEDGRGLSIWDAFSRIPGSIADGSTPEKACDMYHRYEEDLDLAKQMNLDSFRFSFSWSRILPEGKGKISRKGIDFYKRLIDGMRKRDLVPNATIYHWDLPYELERLGGWLNRDVVDWYGEYASILYREFGDTVPLWATVNEPIATYVGYALGGFAPGFKLEKYGRQANHHILLAHGEGIRRFRQENLKDSKAGIVVDVWQHYPLRPDNEKDCEIARLENEKTFRSYLNPIFKGCYRQELLQYMEEKDCMPVIKDGDMERIHQPLDFFGLNCYNRVLDCAEPESAPDRKKNGGNFMENGMEFYPKAVYEAVEMLKKDYQLTIPIYITENGTCNCNEKVQEDGRIRDEQRIEYIRGNLYWIAKAIEEGADIRGYYVWSLLDNWEWCAGFESRFGLVHVDFDTQKRTVKDSGRWYAGIAGSGEMDWKEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4X0</accession>
    <name>F7K4X0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00899"/>
    <dbReference type="EnsemblBacteria" id="EGN43208">
        <property type="protein sequence ID" value="EGN43208"/>
        <property type="gene ID" value="HMPREF0994_00899"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="358" mass="40632" checksum="E342EC73CF997EEA" modified="2011-09-21" version="1">MTSYANTIYLQKGKQLMTMEEMARIIGVSRITLSKVMNDKEGVSEKTRERVKEYIKKYNFEPNSQARSLVGKKEPIIGFFTTYSEESSGSTHITSHFATELVNLVVNAAQKRDYKTLVDITGGDDDFSDIERYLSSGLVRGAILLGYATGNKKLERLSQKGIPLVLINQEEETDLPNIMTVNMNDEVWAFEAIERLVKLQHRRILYIGCSRNRLPAMRRAHGVHRACDMYKDQILSYQERNGDFNEDLAYDITKEIFSAGGETPTGIFAANDLMAIGAVNALKDMGIRIPEEVSVIGFDDITFSRYLTPSLSTVHCDFRMIAEKSVKTLIDSIEGKKVRRHQELDLEFIERESLGRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Z5</accession>
    <name>F7K4Z5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00924"/>
    <dbReference type="EnsemblBacteria" id="EGN43233">
        <property type="protein sequence ID" value="EGN43233"/>
        <property type="gene ID" value="HMPREF0994_00924"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="169" mass="19514" checksum="BA45A4352E26227C" modified="2011-09-21" version="1">MDNQATGLFIKQLRTEKNLTQKELADRLHVTDKAVSKWERGLSLPAVDLLQPLSQALGISVVELLDAQRHQDNSIDLQKANAILEATTRRLKKTIRRKRLALLIIFILLFITTRISGRIIWNQGLLLDESSLGIQDIYYTPWDSTLSWIRFALQFLLLWITFFAALRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K505</accession>
    <name>F7K505_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250890.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00941"/>
    <dbReference type="EnsemblBacteria" id="EGN43250">
        <property type="protein sequence ID" value="EGN43250"/>
        <property type="gene ID" value="HMPREF0994_00941"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1028"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN43250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="229" mass="26161" checksum="CB3211F62E96EFC1" modified="2011-09-21" version="1">MGKRVLVVDDEKLIVKGIRFSLEQDGMEVTCAYDGEEALENAKNTEFDIILLDIMLPKLTGLEVCQQIREFSNVPIVMLTAKDDDMDKIMGLEYGADDYITKPFNILEVKARIKAIMRRTTVRDSASNAPKTIVNGDLRLDCDSRRVYIAGKEVNLTAKEFDVLELLALNPNKVYSRENLLKLVWGSDYPGDVRTVDVHIRRLREKIESNPSEPRYVHTKWGVGYFFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K571</accession>
    <name>F7K571_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01009"/>
    <dbReference type="EnsemblBacteria" id="EGN43318">
        <property type="protein sequence ID" value="EGN43318"/>
        <property type="gene ID" value="HMPREF0994_01009"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1100"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="35873" checksum="AB0630265D7E886F" modified="2011-09-21" version="1">MHVCRVCSPFSGKDKNMAKNAAVPKRKFKKEWLKGYLFILPNFVGFLIFMGIPIIMGLIISFTNYDGFKTFDFVGLSNYVKMFKDEYFQVSFVNNLIYTGVTVPCTILIALLLAVALNVGIKGTGLFRTMFFFPNISSMVAVGIVWSMIFHPTRGPLNLFLYNIGVTNPPQWLVSSKTALLSVMIVAVWKQAGYYMVMILAGLQSIPKQLYEAAEIDGANGLKRFFHITLPMLSPTMFMVTILSLISSFQVFDLISIMTEGGPGRATNVLVYRIYQEGFKYLNFGYASAMAYFLFLIILIITLIQFRGQKKWVTYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5D5</accession>
    <name>F7K5D5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251013.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01064"/>
    <dbReference type="EnsemblBacteria" id="EGN43037">
        <property type="protein sequence ID" value="EGN43037"/>
        <property type="gene ID" value="HMPREF0994_01064"/>
    </dbReference>
    <dbReference type="GeneID" id="29724616"/>
    <dbReference type="eggNOG" id="ENOG50337HU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133679_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="141" mass="16689" checksum="8F5430A575F71DDC" modified="2011-09-21" version="1">MKKEDLLRAGCMVPDTLQEAMRSGRQEMAEGDEEALETYVCHLLEENGRENTYFDFYFGTLSQEEQRRAEMVLSSEQVRFLHESDLPDSREDVYFPFEESLFAIALRFSVTQMLFSTFYFPMLRKTVWSSYEGKFIVFSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5Q0</accession>
    <name>F7K5Q0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH43_C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01179"/>
    <dbReference type="EnsemblBacteria" id="EGN42580">
        <property type="protein sequence ID" value="EGN42580"/>
        <property type="gene ID" value="HMPREF0994_01179"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1291"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="7">
        <location>
            <begin position="317"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN42580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="541" mass="60615" checksum="4AE13B55BD2D6A6A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5Q7</accession>
    <name>F7K5Q7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ORF">HMPREF0994_01186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251135.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01186"/>
    <dbReference type="EnsemblBacteria" id="EGN42587">
        <property type="protein sequence ID" value="EGN42587"/>
        <property type="gene ID" value="HMPREF0994_01186"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1298"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="146" mass="15960" checksum="3700281482D3DB79" modified="2011-09-21" version="1">MKKLLKEFEKFIMRGNVIDMAVGVIVGAAFQGIVNSLVNDVISPLLGLIANTDLSYLVLNVRGVDIKYGSFLTAVINFLIMAFVIFLLVKGINKLAELGIRKDKNKKAEEPAKPATKICPYCKSEIPADAVKCCHCTSDLEEPVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5S9</accession>
    <name>F7K5S9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251157.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN42609">
        <property type="protein sequence ID" value="EGN42609"/>
        <property type="gene ID" value="HMPREF0994_01208"/>
    </dbReference>
    <dbReference type="GeneID" id="29723873"/>
    <dbReference type="HOGENOM" id="CLU_2825593_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="66" mass="8017" checksum="3B7F3CCE3870975A" modified="2011-09-21" version="1">MYMQVMVQADYKEQEMEEMGIKDMKSTKNNPDKIPENENIYCDSWILILNRDIRNSLVRNNRLQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6H6</accession>
    <name>F7K6H6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251433.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01484"/>
    <dbReference type="EnsemblBacteria" id="EGN41958">
        <property type="protein sequence ID" value="EGN41958"/>
        <property type="gene ID" value="HMPREF0994_01484"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045984_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363752" evidence="2">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048" evidence="3">
        <location>
            <begin position="69"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="4">
        <location>
            <begin position="264"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="384" mass="43547" checksum="3F19E317E4DC0448" modified="2011-09-21" version="1">MKKLGVSLLVGLTFAMLLFGCGKEKAEEETVPATEETAESLPVETESETETETVAEDVPPEEGMVRSSLTNEWISGDIADQRPIAVMVPNDSSALPHYSLSKADILYECPVEGNITRLMAIFKDWDNDDMKRIGNVRSSRDYFVYWAFEYDAIYFHFGGPYYIAPVIEQKSTDNVTGANYGGTGKKGIYGNAYYRSSDRKAPQNAYLSAEGANEAIDKLGISKTYRDNYYDPDHFKFAPESSPNTLDQYSNAITVKKLDMAKCYPISKTYFEYNEEDGLFYRFEYGKPHVDAGFDNTQLAFKNVLVQFAYYEVRDEKGYLTFQDHDTTRDGYYFTNGKGIHVNWKKSGDYDPTKFYDDDGNEIELNTGKTMICVVEEGDTFGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Q1</accession>
    <name>F7K6Q1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251510.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01561"/>
    <dbReference type="EnsemblBacteria" id="EGN42035">
        <property type="protein sequence ID" value="EGN42035"/>
        <property type="gene ID" value="HMPREF0994_01561"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1705"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="35250" checksum="8E6F1F6B7BB94156" modified="2011-09-21" version="1">MAQQKTEGKEKKKKKSLYRTRELHIMLIPAVLFTTFFAYLPIFGLVMAFQDFKPLMGFRESPFVGLQQFRYIFTMPSFRTAFVNTMIISFFKIILSILVPMILSLMLNEVTKSWFKRSVQTIVFIPYFFSWAILAGMILEIFAYDGIINNTMLHLFGTDPTAFLVSNKYFRTIIIGSDVWKGMGYNTVLLLAAITNVDPTLYEAAQVDGAGRWKQVLHVTLPCILPMVAVLTVLGLGNILNAGFEQILIMYNPTVEKTVDILDTLVYRLGMTSHQYSAAAAMGLFKSVISLIFVGTSYLILYKKSDYRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Z2</accession>
    <name>F7K6Z2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251418.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01469"/>
    <dbReference type="EnsemblBacteria" id="EGN41943">
        <property type="protein sequence ID" value="EGN41943"/>
        <property type="gene ID" value="HMPREF0994_01469"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1602"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_19_8_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="263" mass="30424" checksum="E7C50039E97E19FC" modified="2011-09-21" version="1">MKLEILVSAVNEDVDTLAERMNLQADAIIVNQCGENTYREYTYQEHRIRCYSFAERGVGLSRNNCLMRAQGDICLFADEDIIYRPGAVRAIEAEFEKNPDADMILFNMDVPEDRATYHIDGYGRVRWYNCGRYPTYSFAARTEKLREANIAFSLLFGGGARYSNGEDSLFLAECIRKGLKVYKAPVTIGKENGRPSTWFHGYNEKFFYDRGVLYHFLYGKAAFLMALRFLYKQKDVMCKEFSFREAFALMRRGIRMEKGAGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K737</accession>
    <name>F7K737_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251579.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01666"/>
    <dbReference type="EnsemblBacteria" id="EGN41783">
        <property type="protein sequence ID" value="EGN41783"/>
        <property type="gene ID" value="HMPREF0994_01666"/>
    </dbReference>
    <dbReference type="GeneID" id="29724896"/>
    <dbReference type="HOGENOM" id="CLU_2423179_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="91" mass="10107" checksum="9A7091C515ACF0ED" modified="2011-09-21" version="1">MLNSTGYYKHILKCSEQMEDGRMILFDPDSGKTHVLNATAGKIYRLCTNTAPEGIALSILEEGMDVDKEVILEDVCDTIQNFVELKIIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7E9</accession>
    <name>F7K7E9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251691.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01778"/>
    <dbReference type="EnsemblBacteria" id="EGN41591">
        <property type="protein sequence ID" value="EGN41591"/>
        <property type="gene ID" value="HMPREF0994_01778"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1940"/>
    <dbReference type="eggNOG" id="COG0814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719137_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003333">
        <property type="term" value="P:amino acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018227">
        <property type="entry name" value="Amino_acid_transport_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03222">
        <property type="entry name" value="Trp_Tyr_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="379" mass="40420" checksum="35177C56BE8B6921" modified="2011-09-21" version="1">MKNKQLTIVESACIITGYGIGGGVMAMPYLAQRNGCLMSLLILAAAFLASFILHVMIAELAVKSGGGSQIIEVFSRYLFQGKYKKVLTLAFFVIMALVLFTNLAAYISGAAEIISELLGISLWLSRLLFYAAAASVVLFGLKAVGVSEKLAVGVIFLLVGLLACFSMLHIQNPLPVKAGSITEGLAYFGMGMFAFSAFFSVPQAVSGLGGDGKKVRKAVFLGLLNNFILITVITVCALLSSTQVTEVAMIGWSKGIGSWAEMVGSLFTILAMLTTYWSISLALADIVEEQLKLSRRLCWVIATLPSLALTFAGLGGFMEFMRLAGGLIAILIALLVVPAFRKASREPGNSLLGRWSGGWMQILIIIAYVLMAVGNVVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7H9</accession>
    <name>F7K7H9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251721.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01808"/>
    <dbReference type="EnsemblBacteria" id="EGN41621">
        <property type="protein sequence ID" value="EGN41621"/>
        <property type="gene ID" value="HMPREF0994_01808"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1974"/>
    <dbReference type="eggNOG" id="COG0338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063430_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000398-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="31025" checksum="D9FE57DC01A40B4E" modified="2011-09-21" version="1">MNSTPIAPFIKWAGGKRQLLPQISAKLPETYNTYYEPFVGGGAVVFALCPACAVINDINPALVNLYRQIKTSPGAVIALTDRLDEEAAADGKACYYARREIFNDKMKKKEFDGELAALFLYLNKHCFNGLYRVNEKGYFNVPYNNSRARSCSPENILAVSEYLQKVTIMEGDFQDACRDAARGDFVFFDSPYAPLNPSSFESYTKEGFDVESHQRLAGLFRELTERGCSCMLTNHNTDFINELYEGFRKEVVVVKRNINSDASKRVGEEIIITNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7L2</accession>
    <name>F7K7L2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41655">
        <property type="protein sequence ID" value="EGN41655"/>
        <property type="gene ID" value="HMPREF0994_01842"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2699996_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="73" mass="8007" checksum="3CC84A2E48707B9F" modified="2011-09-21" version="1">MASLTDDNAVLAGIASTHYCDIHTTRYKIASSTILVPLRFYPSESVLLKGILPDRSRRVRNAKKQDGTAEDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7N8</accession>
    <name>F7K7N8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251845.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01932"/>
    <dbReference type="EnsemblBacteria" id="EGN41337">
        <property type="protein sequence ID" value="EGN41337"/>
        <property type="gene ID" value="HMPREF0994_01932"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2121"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_44_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="66" mass="7367" checksum="F436C89224E887E3" modified="2011-09-21" version="1">MPLYNRLKEHRARLGVNQAELGNMAGVSRQTISLIERGDYSPSVTLALKLAAICGTTVEDIFRYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K866</accession>
    <name>F7K866_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251811.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01898"/>
    <dbReference type="EnsemblBacteria" id="EGN41303">
        <property type="protein sequence ID" value="EGN41303"/>
        <property type="gene ID" value="HMPREF0994_01898"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2081"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="242" mass="27329" checksum="9D39F203E964B2CC" modified="2011-09-21" version="1">MKSKVWAHRGASAYAPENTLEAFRMGAEQGADGVELDVQLSKDGQLVVIHDETIDRVSDGHGYVRDYTLEELKKFVFNKTHPEYADARIPTLGEVYDLLKPLGLEINVEIKTGIYFYPGIEEKLYLLEKEKGMQGKIIYSSFNHYSVMKMREYDPAARTGLLYADGFQDVPGYAAGLGADALHPALYNLQYDGFLEACREKNLLLHVWTVDDEKYMKLLVKEGIDAIITNKPDVARKIVDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8C8</accession>
    <name>F7K8C8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251817.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01904"/>
    <dbReference type="EnsemblBacteria" id="EGN41309">
        <property type="protein sequence ID" value="EGN41309"/>
        <property type="gene ID" value="HMPREF0994_01904"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2087"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="288" mass="32429" checksum="AD21B697810DA107" modified="2011-09-21" version="1">MLRKKQYPVYFILPGIFLFVMFFIVPFLVGFRYSFTNWNFKRADFIGLENYISILKNPNMSIAFKNTFLFTMVTTVGKVSIGMLLAVLLNRKLKTTNYLRTVFYLPAVVNSIAVGIVFTSLMHPSKGLINTALRTIGLTGFQPKWLTDTSIAMLSICFIEIWKWSGYTMMILLAGMQNISRDYYEAAIMDGATKWQQFKKITFPLLMASINNVVVLSIIGGLKVFDIVVATTGGGPGYATEVFNTMIYNSYSYQKYGEATAGTTLLAGMILIITLCTYRTIAKNEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Q7</accession>
    <name>F7K8Q7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4180 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252154.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41160">
        <property type="protein sequence ID" value="EGN41160"/>
        <property type="gene ID" value="HMPREF0994_02253"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2461"/>
    <dbReference type="eggNOG" id="ENOG5032Z57">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151995_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025438">
        <property type="entry name" value="DUF4180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13788">
        <property type="entry name" value="DUF4180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4180" evidence="1">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="126" mass="14256" checksum="F4DEFC8F80BA9C49" modified="2011-09-21" version="1">METEVVNKNNVSVAVIHSDEHLITDVQSALDLIMSVKYETGCTNFALNKSAIVDDFFILSTCMAGEILQKFINYGVRFAIYGDFSRYTSKPLKDFMYESNRGKDIYFQPSVSRAVDKLSGYSKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8S0</accession>
    <name>F7K8S0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41174.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359782.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02267"/>
    <dbReference type="EnsemblBacteria" id="EGN41174">
        <property type="protein sequence ID" value="EGN41174"/>
        <property type="gene ID" value="HMPREF0994_02267"/>
    </dbReference>
    <dbReference type="GeneID" id="29725575"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123225_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41174.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="28654" checksum="CA89CD535EE6B43B" modified="2013-09-18" version="2">MKIATYNIWNDNRGWPDRVEQICDEIKTQNADLLCLQDVPDEDTCKYIAEEGKYGFYSFVKHPSCELAILSKYPFLDDYSFGEAQIVNVKAGNYVLEVINVHLPWDSVLSCEKQVIALVNQNKKTKADYSVFCGDFNCEAGSSVQNFLLGKQSLYGEEAVPYWEDLAIVYQNITGMEPEATLDLASNPRWKDHGYKSCAGTRIDWILLKYSYPNPSPKLKTFCLFGRKISPKTGYCPSDHYGVLAELDFDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8X4</accession>
    <name>F7K8X4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">HMPREF0994_02159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252072.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02159"/>
    <dbReference type="EnsemblBacteria" id="EGN41066">
        <property type="protein sequence ID" value="EGN41066"/>
        <property type="gene ID" value="HMPREF0994_02159"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2362"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="312" mass="34753" checksum="3BA09C9439C4398C" modified="2011-09-21" version="1">MEFVHKSVLLDETIEGLAIKPDGIYLDGTLGGGGHSSEICRRLADGHLIGIDQDEEALAAASERLKPFQDKITLVRDNYCNAPEVIKNLGITGVDGIVLDLGVSSYQLDNVERGFSYRYDTALDMRMDTRQSLTAREIINEYPERELYRIIRDYGEDQFAKNIAKHIAAARKEKPIETTGELNELIKAAIPARMRANGGHPSKRTFQAIRIECNHELDVLKNSLDELIAMLNPGGRICIITFHSLEDRIVKSAFRKNENPCTCPPDFPVCVCGKKSQGKVITRKPVLPGEEELETNSRSKSAKLRIFEKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Y9</accession>
    <name>F7K8Y9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252169.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02268"/>
    <dbReference type="EnsemblBacteria" id="EGN41175">
        <property type="protein sequence ID" value="EGN41175"/>
        <property type="gene ID" value="HMPREF0994_02268"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2476"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="3">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="4">
        <location>
            <begin position="206"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="337" mass="37322" checksum="F353BE67B324123A" modified="2011-09-21" version="1">MHQLIKPKKLNPGDTIATISLSGGRAGDPDMIERYLFGKRQLEEHFGVHVIEAPHSLKGKDFLYENPKLRADDLIWALTNPRIKGIFVNSGGDDGGRLLPYIDFNIIRNNPKILLGYSDVSVFHAMFTHAGVSSFYGANLLATIAQPGGLDDYTERWIKKALFLENVMGEIVPCDKWADIEWDKTKKSVWVQNTGYELLQGSGIVRGRLLGGCCGSLLQIMGTEIFPDKKLWKDSILFLDIGTPYGVEVATLHQIRAFASAGIFRQAGGLICTGMHESDKEILLKVIRQEEDLPDLPILYNADIGHRIPMTVIPMGALAEIDCNNNTFSILEAGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K921</accession>
    <name>F7K921_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">HMPREF0994_02359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252260.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02359"/>
    <dbReference type="EnsemblBacteria" id="EGN40758">
        <property type="protein sequence ID" value="EGN40758"/>
        <property type="gene ID" value="HMPREF0994_02359"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2581"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="223" mass="24599" checksum="251044F508854C9F" modified="2011-09-21" version="1">MSYNIAIDGPAGAGKSTIAKQLAKKLGYVYVDTGAMYRAIALYLLREKVKPDDTEAVSNTCTGAEVTLIYQDGEQAVLLNGENVNGFIRTEEVGNMASRASAVPAVRERLLQLQRDLASSENVIMDGRDIGTCVLPNADVKIFLTANSAVRAKRRYEELLAKGTPEAFEKIEKDIIERDARDRNREIAPLRQAEDAYLVDTSDMDIPQVVDTILEICRQKGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K988</accession>
    <name>F7K988_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02432"/>
    <dbReference type="EnsemblBacteria" id="EGN40831">
        <property type="protein sequence ID" value="EGN40831"/>
        <property type="gene ID" value="HMPREF0994_02432"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2664"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="304"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="635" mass="72846" checksum="D1A993BB19E68E6C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9B6</accession>
    <name>F7K9B6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="10">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycogen branching enzyme</fullName>
            <shortName evidence="10">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glgB</name>
        <name evidence="14" type="ORF">HMPREF0994_02465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40864.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359764.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02465"/>
    <dbReference type="EnsemblBacteria" id="EGN40864">
        <property type="protein sequence ID" value="EGN40864"/>
        <property type="gene ID" value="HMPREF0994_02465"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_9"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="13">
        <location>
            <begin position="254"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN40864.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="808" mass="92477" checksum="274EC042428B1E13" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9F9</accession>
    <name>F7K9F9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NitT/TauT family transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252420.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02519"/>
    <dbReference type="EnsemblBacteria" id="EGN40918">
        <property type="protein sequence ID" value="EGN40918"/>
        <property type="gene ID" value="HMPREF0994_02519"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2761"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="256" mass="28561" checksum="46FDC0C9A43C2449" modified="2011-09-21" version="1">MEDIILSLKNIAFSYHSLNGEIKALDNISFSVRTGEFLAIVGPSGCGKSTILSLIAGLLQPESGDITFYTKDPHDKKPGIGYMLQHDHLFEWRDIYKNVTLGLEINKQLTPEKKEKVLSMVNDYGLSPFLHKKPSELSGGLKQRAALVRTLALEPEILLLDEPFSALDYQTRLTVSADICRIIRSAGKTAVLITHDLSEAVSLADRVIVLSNRPARVKAEIPIHLTLKDDSLLASRNAPEFKDYFNQLWEELTDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9M3</accession>
    <name>F7K9M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine/putrescine transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252348.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02447"/>
    <dbReference type="EnsemblBacteria" id="EGN40846">
        <property type="protein sequence ID" value="EGN40846"/>
        <property type="gene ID" value="HMPREF0994_02447"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2681"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="28979" checksum="3B43F9CC95FD5DC3" modified="2011-09-21" version="1">MKTRQTLLQKIYIGLIFVFLYAPIVTLMVLSFNASRTRAKWGGFTLKWYSELFQNSIILEALYNTLLIAFLSSAIATVIGTIACIAINGMKKRNRAIMMGITNIPMLNAEIVTGISLMLLFISLGVRFGFGTILLSHITFNIPYVILSIMPRMKQLNPSTFEAAMDLGASRIKAFFKVVFPDLLPGILSGFLMAFTMSLDDFIITHFTKGPGIDTLSTKIYTEVKKGIKPEMYALSTIIFVTVLILLLLVNKAPVKQDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9T9</accession>
    <name>F7K9T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252523.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02622"/>
    <dbReference type="EnsemblBacteria" id="EGN40605">
        <property type="protein sequence ID" value="EGN40605"/>
        <property type="gene ID" value="HMPREF0994_02622"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2875"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="355" mass="40164" checksum="46F63D11F6136F04" modified="2011-09-21" version="1">MATIKQIAEELGISPTTVSNVINGRTGKMSAETREKIEEALCKYHYETAGKSGGAAAEENMIAVGFCMGRNKNVMTDPFCGELLGAIQKAVKSYGRYIVLDVPETEEDLIRLCAPWNIDGAIVLGWNPEQCARLQQKINKPLVFIDSCFEDMEAEHSMETEYSMEAYDNIGLQDYEGAFELISYLLRLGHRNIAFFSDQEPPMASNRERFRGYQDALKAFGVPFSREDFYFLPENKTMRHEVLRQFARKNGKKYSAAFFISDYYANEAITVFYSKGLNVPDDISVVGFDDNIYARLSRPALTTVRQLPEEKGKQAVELLMKRIRGEESPVRSLTLPTELIVRESTKAVFPSEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA09</accession>
    <name>F7KA09_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252593.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02692"/>
    <dbReference type="EnsemblBacteria" id="EGN40675">
        <property type="protein sequence ID" value="EGN40675"/>
        <property type="gene ID" value="HMPREF0994_02692"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2946"/>
    <dbReference type="eggNOG" id="COG0252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="8">
        <location>
            <begin position="206"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="333" mass="37161" checksum="EC2B9B46E6C6C993" modified="2011-09-21" version="1">MPKKKILLLTTGGTIASHKTEYGLAPALTAEEILDFLPSMSSICHLEARNLFSIDSTNMTSAHWMQIAGAIEESFSGYDGFVILHGTDTMAYTAAALSYLIQNSPKPIVLTGSQRPLEMEISDARMNLRDSIVYALDEASVGVSVVFGGKVIAGTRAKKVKTMSYNAFASINYPELAVMRDEHLVRYIEQKPFCEPLAFYHELNSRVFLLKLTPGMSPLILKDIFSQYDGIIVESFGVGGIPDSLIHEFVRLMKEYGTGKAVVMTTQVTYEGSNIGVYEVGKRVQEQFPLLEAYDMNLEAVFTKLMWILGQKPAGFEEVRNLFYKTINYDFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA42</accession>
    <name>F7KA42_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02727"/>
    <dbReference type="EnsemblBacteria" id="EGN40710">
        <property type="protein sequence ID" value="EGN40710"/>
        <property type="gene ID" value="HMPREF0994_02727"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2983"/>
    <dbReference type="eggNOG" id="ENOG50329QI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092357_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363836" evidence="1">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="198" mass="21632" checksum="9157DE3CB9A41F1D" modified="2011-09-21" version="1">MKKISLFLLAVCGIALLMAGCGSKETEEDVSTLELKKNGEIVHTIVEDFGESYYDLDELKSSTEEMIADYNSSAGADRVKLNSAQTQDGVVRLVMTFKSSEDYSGFYRQALFSGTVKEAFGAGYDLDVTLNSVKEEGTTISKQDILDMGDKHVAIVRENINIRPYGDILYMSSDVTLGADGKTAVVTNGESLSYIIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAQ7</accession>
    <name>F7KAQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252784.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02883"/>
    <dbReference type="EnsemblBacteria" id="EGN40492">
        <property type="protein sequence ID" value="EGN40492"/>
        <property type="gene ID" value="HMPREF0994_02883"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50327DY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2180447_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="109" mass="12172" checksum="365CD64193CDE023" modified="2011-09-21" version="1">MSKGLKICLWIVLVMDILTFLFYGRTFLLADASAAAAGMILELIQIAGVSILLFNRRKTGFYIICLSEVVIFAVNVTLFGSDIIMSLINSAVVPLAVYAFMKPFWNTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAR0</accession>
    <name>F7KAR0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">HMPREF0994_02886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252787.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02886"/>
    <dbReference type="EnsemblBacteria" id="EGN40495">
        <property type="protein sequence ID" value="EGN40495"/>
        <property type="gene ID" value="HMPREF0994_02886"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3155"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="414" mass="45078" checksum="27422119172C404C" modified="2011-09-21" version="1">MDLTEMGRAAVAAKYEVQKMTAEDKNASLKAVAEGLLRDKATVLAANARDVERAERGGMHPGMVDRLRLTDARMEAMAEGLLQICGLPDPLGEVLEHFTRPNGLEIEKRRVPLGVIGIIYESRPNVTADAFGLCFKAGNACILKGGSDAIDSNTAITESIRRSLTESGSCEDAIQLITDTDRETTSRFMKLNEYVDVLIPRGGAGLIRAVVENSTVPVIETGTGNCHIYVDEFADMEKVIPIILNAKTQRIGVCNACESLVIHEKIREKIMPALAEALQQANVEIKGDERTLLCVPGAVPAAPEDFGKEYLDYILSVKTVDSLDEAIAHINRYNTGHSDSILTENAENAERFLNEVDSACVYVNASTRFTDGFEFGFGAEIGISTQKLHARGPMGLKELTTYKYAIRGNGQIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB43</accession>
    <name>F7KB43_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252974.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03073"/>
    <dbReference type="EnsemblBacteria" id="EGN40250">
        <property type="protein sequence ID" value="EGN40250"/>
        <property type="gene ID" value="HMPREF0994_03073"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3358"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_3_0_9"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="272" mass="31457" checksum="7E755DDBF0FEFCFB" modified="2011-09-21" version="1">MAIKADFHLHSSFSGDSEAPMEDMIQKGISLGLTQMCFTEHMDFDFPVSQDTPAGFFEVNTDSYLYDLLKYQAKYREQIQIFFGIELGLQAYLNELQSAYTSAYDFDFIIGSSHLCNGRDPYNAGFYTGRSEEEAYREYFSSIIENLETFHDFDIYGHLDYVVRYGPNKDKNYTYETYKDLFDRMLDLLLENGIGIEINTGGIRYGLKELHPCMDVLKRYREKGGELITVGSDAHRPGDICREFGRAEALLRDCGFSYYAVFHKRTPSFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB96</accession>
    <name>F7KB96_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253026.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03125"/>
    <dbReference type="EnsemblBacteria" id="EGN39955">
        <property type="protein sequence ID" value="EGN39955"/>
        <property type="gene ID" value="HMPREF0994_03125"/>
    </dbReference>
    <dbReference type="GeneID" id="29728776"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3417"/>
    <dbReference type="eggNOG" id="ENOG502Z7PW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046838_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014194">
        <property type="entry name" value="Spore_III_AE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09546">
        <property type="entry name" value="Spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="352" mass="37533" checksum="615AE5ABE7792D4C" modified="2011-09-21" version="1">MELTTLAGELNLDDLSHQIEQLFPDFSIDFTSFFGQVLAGNMGEAFRGLSSSLRNGILAEIGGMKNLMLTLLIIGVLSALFTVVMQSFDNHQIADIAHFISYLLMLFVVLRTFTQAADIAGVLLERILLFVRLFVPTFMLALGLSSGAATAAGYYQLILLLIYGVEQLLVSIGLPAVNIYMMLVVMNGVWEEEKLGMLVDLLQKGIGGFLKFMLTCITGIGLLQSMVTPVLEQLKLNVAGKALSAIPGLGGLAEGTAQLLIGSAVLVKNGLGVAAFLLLLALCIVPFAKLLLYAGILKLCAALLGMTADKRITGCVNKAGDGLLLLLRISFTACACFLIMFAIITCLAGRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBC7</accession>
    <name>F7KBC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253059.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03158"/>
    <dbReference type="EnsemblBacteria" id="EGN39988">
        <property type="protein sequence ID" value="EGN39988"/>
        <property type="gene ID" value="HMPREF0994_03158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="268"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="385" mass="45905" checksum="109168F5E4D23F24" modified="2011-09-21" version="1">MYKIIIVDDEPLMLEGFSKVINWNEHGYQLIGAFRNPLEILDFCEANCPDIILLDINMPDMDGISLLKEIKQRYPKTHVIMLTAHNEFKYVRDSLRYHADEFLWKPEMEFEDILSCMNRIMEAGEKEEKEQEARNYATVEFTDYREEEYRFSRDYFSNLLQEFKKALEMEDIGRIKEESEDLWRMIVQDRPKKADIMGGFMHLIYLYQERLRTYKAPSDIMIDEEQVLGLFHQKYSYQELIEGLKEILDERNQYLEAQRQEEDNRLKGMIASYIADNMQMTDLNLMHLSKEFNLSYSYFSRLFPEVMGKNFSKYLVEARMEKACDYLKNSDYKIDRILEMVGYNDKSYFIKSFKGYTGMTPSKYRDKYRISGRGLGSLTGQMGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBS1</accession>
    <name>F7KBS1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253214.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03313"/>
    <dbReference type="EnsemblBacteria" id="EGN40143">
        <property type="protein sequence ID" value="EGN40143"/>
        <property type="gene ID" value="HMPREF0994_03313"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3621"/>
    <dbReference type="eggNOG" id="COG4908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031688_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046283">
        <property type="entry name" value="DUF6320"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19845">
        <property type="entry name" value="DUF6320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="604" mass="69206" checksum="9C1ED3E8921A4136" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC36</accession>
    <name>F7KC36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253316.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03415"/>
    <dbReference type="EnsemblBacteria" id="EGN39922">
        <property type="protein sequence ID" value="EGN39922"/>
        <property type="gene ID" value="HMPREF0994_03415"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAPZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022123_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="268" mass="29580" checksum="690D6F113E1A19EF" modified="2011-09-21" version="1">MLNMLRMDLRRMFRVKMMFIAFLCLAAGILISIITLRTVTDPELRQQAIESGVEITTSDETDFESIRSLTETQALCTTIYSGSFIFVALYIVVVLFVCNDYSSGFAKNIFSFYGGRWCYYVSKLLCMTIVCALWILGSFLIFRICSVVSGMNFARSNLVDYLRVFVEYLFIGVAFSAEGIFLSVWLRSEGGGIAAAIVLAGGIVPVMLEALLGNWGISIVYKTLYGSVQAVTANVTYGSPVGEAMAVTAVWLAVWSALSLLALYKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC68</accession>
    <name>F7KC68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253348.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03447"/>
    <dbReference type="EnsemblBacteria" id="EGN39520">
        <property type="protein sequence ID" value="EGN39520"/>
        <property type="gene ID" value="HMPREF0994_03447"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1803699_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="143" mass="17023" checksum="23658ECE6EAD8DD9" modified="2011-09-21" version="1">MTKFTLEKRQLCDIQGRLFELALKNGYDCPAFIKDFMNSQTASALDDTYDRLQWAGEEYILEELDEEVNGLKKEGITYPVEVMYWIGYTYRYWHYYTKEASREIYKTANADTMNECWLGFHTLDVEMAIDNLKEIYRQNCDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC82</accession>
    <name>F7KC82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03461"/>
    <dbReference type="EnsemblBacteria" id="EGN39534">
        <property type="protein sequence ID" value="EGN39534"/>
        <property type="gene ID" value="HMPREF0994_03461"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033KN0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171627_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="82" mass="9250" checksum="BF3A334C52D3D6B0" modified="2011-09-21" version="1">MYLTYPIDILSFLNTVKICKGNVFFRTKEGDSLNLNSLLSQFIFTSIVCDEHFLASGEIYCENAEDYHTLENYLADAAPSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCA0</accession>
    <name>F7KCA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03479"/>
    <dbReference type="EnsemblBacteria" id="EGN39552">
        <property type="protein sequence ID" value="EGN39552"/>
        <property type="gene ID" value="HMPREF0994_03479"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3804"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023504_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024749">
        <property type="entry name" value="Collagen-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025277">
        <property type="entry name" value="DUF4038"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12904">
        <property type="entry name" value="Collagen_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13204">
        <property type="entry name" value="DUF4038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4038" evidence="2">
        <location>
            <begin position="37"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen_bind_2" evidence="1">
        <location>
            <begin position="372"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="461" mass="53029" checksum="5554C1C684021646" modified="2011-09-21" version="1">MKFETNDVSHLEWMSEEADKENKYEKPWENGSLRVTKNGRYFCCGDTPFFWMGDTAWLLFHQLTSREAYCYLRGRKELGYNVILADFLHTPEQVNLAGESALEEGDFSRIKKDGVFWKHVDQVIKMAEELGLYMGLLPVWGSSIVAGGSLNAGNLDGYLDFILERYHDAPNLIWIVGGDVRGDVNPGLFCRMGRRMKEDRPDRLVGYHPFGRTSSSLWFHEEEWLDFNLFQSGHRRYDQTELGAWDDNSEKEGCFGEDCWRYVKTDYEKLPVKPVLDGEPSYEWVVQGLHDLTQPYWKAADVRRYAYWDVFAGAAGHTYGHNSIMQFYRDLSQKGAFGAKYLWSDAIHHPGGAQMIHLKRLMESVDYGNGRPAQELLLMEEGLKYDYVSVFAGENFLFAYTCTGRAIRLSLTKFKGKIKSAYWMDPVTGMQTFICDVTGKEEAVFLPPEREDGSDSVLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCE4</accession>
    <name>F7KCE4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_42 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253424.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03523"/>
    <dbReference type="EnsemblBacteria" id="EGN39432">
        <property type="protein sequence ID" value="EGN39432"/>
        <property type="gene ID" value="HMPREF0994_03523"/>
    </dbReference>
    <dbReference type="GeneID" id="29728797"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3848"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013448_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="1">
        <location>
            <begin position="407"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="706" mass="81075" checksum="58A525239B89FA1F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCI6</accession>
    <name>F7KCI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator, regulatory protein PadR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253471.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03570"/>
    <dbReference type="EnsemblBacteria" id="EGN39479">
        <property type="protein sequence ID" value="EGN39479"/>
        <property type="gene ID" value="HMPREF0994_03570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3901"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="108" mass="12889" checksum="6FF2F6B4767BBEF7" modified="2011-09-21" version="1">MNAQFKKGVLELIVLESVRQKDMYGYELVEEVSKVVDVNEGTIYPLLKRMTNEHYFETYLRESTEGPPRKYYHITAAGILYRDSLERDWNEFNQKVCSFLEEQKRGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCL1</accession>
    <name>F7KCL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253498.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39506">
        <property type="protein sequence ID" value="EGN39506"/>
        <property type="gene ID" value="HMPREF0994_03597"/>
    </dbReference>
    <dbReference type="GeneID" id="29728456"/>
    <dbReference type="HOGENOM" id="CLU_949250_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="32413" checksum="7617DD84AC1EFAF7" modified="2011-09-21" version="1">MKKIDFCEVLGDINEKYVKMAHAPNTKKRPAWIKWGAMAACLAAVAITAVSVLPNYLNRPDTTSSDNPNGIITVRPSDNIPPAASELHISMKNIVLNEIAEYTDTARKWYNPDLYDYITWDKDVITDYYGKDLTPAYIPDGLIAAPSNGTATVITDKRGNIIEDTIGLGFYHAYYEDGSPKLTEDIAAVKGFSIIISKIGLLNDCIYLLPKNEVKTSDIDGTAVTFGYRSMPYGPYDPDTHKPSGYYDMYTAEFTCDEIEYQIVAEQMDIEEVIKVVISACSPAQGEGDSPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCM9</accession>
    <name>F7KCM9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1_PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03577"/>
    <dbReference type="EnsemblBacteria" id="EGN39486">
        <property type="protein sequence ID" value="EGN39486"/>
        <property type="gene ID" value="HMPREF0994_03577"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3908"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="196" mass="21883" checksum="B6FCBE40B3A3CBB0" modified="2011-09-21" version="1">MTTKMNKNEILLLLTDRWCDWEAAYAIAVANSFSDYTVKTIAAEGESMLSMGGLKTEIDYCIKDYRDFSNTAIVILPGGLSWEENDYDEITEFLTLLAAEGIPIAAICGATTYLCRHGFLNHVKHTGDSLELFQSQDGYTGQELYVPAQVVADGGFITANETAAVEFAYEIFKLLKVDSDEEMSQWFDNFKYGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCN7</accession>
    <name>F7KCN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253517.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03616"/>
    <dbReference type="EnsemblBacteria" id="EGN39211">
        <property type="protein sequence ID" value="EGN39211"/>
        <property type="gene ID" value="HMPREF0994_03616"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="421"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="527" mass="59988" checksum="3ED56A21928A1709" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCQ4</accession>
    <name>F7KCQ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253534.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03633"/>
    <dbReference type="EnsemblBacteria" id="EGN39005">
        <property type="protein sequence ID" value="EGN39005"/>
        <property type="gene ID" value="HMPREF0994_03633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="34988" checksum="48728779E46EF3D6" modified="2011-09-21" version="1">MFGKVLDKLGIKTRKGKENAYGYIFILPWLIGILCFTLGPMIFSLITSFTNYNMLKMDFTGLANYKKMFFQDQLFWKALKNTLYYALLNIPLITAGGVIVAVILNKSIFGLRTFRTIYYLPSIMVGVGTYFLWMLLLDPANGLVNSALALIGIKGPAWLTDPNWTKPAIILMHLWGLGGQMLLYLARLQSIPQDYYEAASLDGASGFKKFTKITVPLLSPIIFYNLTIGIIGAFQIFQEGYIFSGDGTGKPAGSLLFYNLHLWNQAFKNFKTGYANAMCWFLFAVVMILTVINQKISNKWVYYEEGESND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD36</accession>
    <name>F7KD36_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03765"/>
    <dbReference type="EnsemblBacteria" id="EGN38830">
        <property type="protein sequence ID" value="EGN38830"/>
        <property type="gene ID" value="HMPREF0994_03765"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="177"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN38830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="276" mass="32683" checksum="ED80E4D9FC05F416" modified="2011-09-21" version="1">MEKELKFYEKKILNDKEFPIQLHINRVHEKRWYFSPHWHEHIELHYVVSGRTKFLLDQQEIPGEKGDLVIANSNVIHAGYCYGSPVEVLVMIFEMEALSEELADKNILFQPWIKKDTEIGRIMHRIYEENEKKDIGYKLACKGGLLQIITYLSRNYVQEMLSNSDSLKRRKKLERLNTVNQYIEQHYTEAISNRELADLLHLSEDRFNHLFKESMGMPPLQYINEIRLKKAMHLLKKGDFYTAAEVADAVGFSDYNNFGRMFRRFYGCTPLEVIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD48</accession>
    <name>F7KD48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253678.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03777"/>
    <dbReference type="EnsemblBacteria" id="EGN38748">
        <property type="protein sequence ID" value="EGN38748"/>
        <property type="gene ID" value="HMPREF0994_03777"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1624975_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363674" evidence="1">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="163" mass="17935" checksum="8C6E6F95B232CBB4" modified="2011-09-21" version="1">MKKIVVILLSALACCTMFIGCSNSSANQEQRLSVYSFSGENEQFAISNGVIVLNSTEETFYGGDLKEKQDKLSDIAAYTKTFYVMSGNEKKILMSFVVEDMTGGTVNISGDTGKISGDIMTKIGTDELQNNLFFELKTTDLNGEENEYQLQLTVTEVTEKADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDD5</accession>
    <name>F7KDD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03868"/>
    <dbReference type="EnsemblBacteria" id="EGN38633">
        <property type="protein sequence ID" value="EGN38633"/>
        <property type="gene ID" value="HMPREF0994_03868"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="225" mass="26251" checksum="F2022D2914B01F64" modified="2011-09-21" version="1">MKIITFDLGGTLMEYAGMPASWTDYYKQGFEAINSYYNCKVSEDYIEQSVEILKSFNPRLHYREEEYSPNYIFSKALEHWGKNIPIRDCVYQFYTGLKLKAEIYPDTIPSLIKLKNNGYLITTLTDLPTAMPDELFKRDISILLPYFDLYVSSLSCGFRKPNCRGLQMIAEYFNVPITELVFVGDEDKDRETAIHADCQFIQINRKNRTSETIFNLTELIEKLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDY9</accession>
    <name>F7KDY9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253969.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04068"/>
    <dbReference type="EnsemblBacteria" id="EGN37104">
        <property type="protein sequence ID" value="EGN37104"/>
        <property type="gene ID" value="HMPREF0994_04068"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4438"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357305" description="Rhodanese domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="145" mass="16018" checksum="BB76B28E64A9DFCF" modified="2011-09-21" version="1">MNRIKRIIPVILITVVLAGILAACGSRSENGGTKKEDEMKGEYHKITAEEAKERMDSGDDIIILDVRTQDEYEESHIPGAILIPNETIGTEMPEQLPDAGQEILVYCRSGNRSAQAAKKLVEAGYTQIYDFGGIMDWPYETVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEI4</accession>
    <name>F7KEI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04270"/>
    <dbReference type="EnsemblBacteria" id="EGN36550">
        <property type="protein sequence ID" value="EGN36550"/>
        <property type="gene ID" value="HMPREF0994_04270"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="34271" checksum="DB41B1A1E544FE69" modified="2011-09-21" version="1">MKEKKTIRMSTWNNIVGWSFALPAVLGFLIFNLMPMALSGYYSLCDYNIIGSPSWVGIKNYVVLFSGQEKTFWLSAKATILYAIMAVPANLIFAFMIALLLNCEMKGRAFFRSLFYLPCILPAVATSFVWLLLMNPDFGLFNTLLELLHLPKSQFFWGRGSVLPSIVFMGIWSTGSTQVIFLAGLQDIPKVYYEALEIDGGNSWHKFWNVTLPMVSSTLFFNLVMGIINALQVFAQAYIITEGGPNNASLFYVYNLWRQAFKYMDMGKASAMAWILFVVVLILTAVVFKTSNKWVYYEGGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEQ1</accession>
    <name>F7KEQ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN35640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254231.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04330"/>
    <dbReference type="EnsemblBacteria" id="EGN35640">
        <property type="protein sequence ID" value="EGN35640"/>
        <property type="gene ID" value="HMPREF0994_04330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4727"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027197_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="138"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="370" mass="42604" checksum="74F9265DBD1ADABE" modified="2011-09-21" version="1">MTNFIIKEQECGYLCRNGKFLRLLTAGKYTYPRAFGYTVEIVPMTGEVKTCGIPEEILMQDKGFASRVVKAVIPDECIALRFVNKAYREVLTRAETLFWNVYEKNEFQMVDITQPCMEDTLPRIYMDLMPAKYYKKITIKDGETGLLYYDLRFEKRLGTGTYYFWNYGREVSCKIFNMKIQQLDISGQEILTADKVGVRLNVVMNYRITNPEKLVEKVDGVASLLYTRAQLILREHVGRYRLDELLSQKEELSGIILEKMKANEEEYCVEIVNAGIKDIILPGEIRDIMNTVLVAEKKAQANVIMRREEVASTRSLLNTARLMEENKTLMRLKEMEYLEKICDKVGNITLNGGKSVLEQLSELTVGKDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF52</accession>
    <name>F7KF52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactose/L-arabinose transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04494"/>
    <dbReference type="EnsemblBacteria" id="EGN35804">
        <property type="protein sequence ID" value="EGN35804"/>
        <property type="gene ID" value="HMPREF0994_04494"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4906"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="31972" checksum="BFD50EC8CFC50EC4" modified="2011-09-21" version="1">MSYKLKMKLAPWCFITPFLIVFVLFAVYPVLYSIVLSFGTYKGGTVNFSGIKNYMFLLSDKSFFQSILNTFKIGIIQVPIMIFLAMVLACFLNSKMVKGKGFFRMAIFIPVLIDAVSYSVIFSLLFNDQGFVNSIIGRLGFTPTSWYINPWLATMMIVIAQTWKWTGYNTIIVLSGLQNIPGELYEAAAIDGASRIQQFFSITIPLLKNMIILVMVTSVNGAVQMFTEPNIITHGGPTGSTTTVMLYLYNMGFKNFNFGIACAGSYVVVFIVVILTMIQMRAGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF77</accession>
    <name>F7KF77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254425.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04524"/>
    <dbReference type="EnsemblBacteria" id="EGN35834">
        <property type="protein sequence ID" value="EGN35834"/>
        <property type="gene ID" value="HMPREF0994_04524"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4940"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN35834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="225" mass="24578" checksum="320BFDC12E0A029A" modified="2011-09-21" version="1">MTILQTADLKKYYGQGTNLTKALDGVDLSVEQGEFLAVVGTSGSGKSTLLHMMGGLDTPTSGSIKVRGKELAEMNDEQLTIFRRRNIGFVFQSYNLVPILNVYENIALPVELDGEAVDLALFDRIVDILSLKEKLDSMPNQLSGGQQQRVAIARALITKPAIVLADEPTGNLDSRTSADVLGLLKMTSEEFHQTVVMITHNNEIAQLSHRIVRIEDGRIVGKAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFB4</accession>
    <name>F7KFB4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254444.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04543"/>
    <dbReference type="EnsemblBacteria" id="EGN35312">
        <property type="protein sequence ID" value="EGN35312"/>
        <property type="gene ID" value="HMPREF0994_04543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="272" mass="30223" checksum="62B9C796B25D8C43" modified="2011-09-21" version="1">MKFPIALQLYSVRDLLEKDLEGGLKQVKELGYDGVELAGLYDHTAAEVKEILDRVGIQAVSAHVPFTDMLEDPEGVLSDYAMLGCRYVAIPYVSDEYRPGHEGFKDLIEGAKVLGEAAKKKGMTLLYHNHDFEFALIDGEYALDVLYREVPASLLETELDICWVNISGEDPAAYIRKYAGRAPVVHLKDFMLKGDKPEQMYQLLGKEEKQNARNEGNFEFRPVGLGLQDIPSVLAASADAGAEWVVVEQDAPSMGKTSMECAKLSIDYLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFJ2</accession>
    <name>F7KFJ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254522.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04621"/>
    <dbReference type="EnsemblBacteria" id="EGN35068">
        <property type="protein sequence ID" value="EGN35068"/>
        <property type="gene ID" value="HMPREF0994_04621"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5044"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_29_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="209" mass="23964" checksum="A231BD21791962B6" modified="2011-09-21" version="1">MGRNRHPEQTLEKIVDVSAELFAKKGYEQTSIQDILDATGLSKGGLYHHFKSKEEILEAVMQKRVQYVNGRFHNIIRNTEETNAKEKLKRILYQLASDMETHSLDKAITARIDPYFVVNGLQSCINQDAPIICEIIEEGIRDGSLQTTQPAFCAEVFLMLLNYWANPILFARNYAETESRLHYLRFVMCQLGLDVMDDNLIAAMLKAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGL0</accession>
    <name>F7KGL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD hydrolase, family IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254890.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04989"/>
    <dbReference type="EnsemblBacteria" id="EGN33784">
        <property type="protein sequence ID" value="EGN33784"/>
        <property type="gene ID" value="HMPREF0994_04989"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5450"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658409_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="280"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="418" mass="47845" checksum="140CADE8BB4786FF" modified="2011-09-21" version="1">MKKHIIFDVDGTLLDSEEAVLLSFQETLYRKTGKKTDIRDLKYALGIPSEAALRQYGFPEEEIPEIVDFWGDLTPDYRKFIKVFPGIRQLLEKLKEKGARLGIVTSRNAEEYRRDFLPFGLESYFDTVICADDTLIHKPYGEPVKEYLRRENARAEDAVFIGDTVYDMDCAADAGVDGALALWGCASPAHIRADYYLSCPEDVFTSFILEQDPLKEHKWLKWAMELQFIAQAGLTYSRDRFDRERFLRIQEIAAEIVSCNTPMDFEQIDGLFAGEMGYQTPKLDSRAAIIRDGKILLVQEMDGTWAMPGGWVDMDQTIKENTVKEAGEEAGMLVAPVRLVAVQDRNRHNKPPYAYNICKVFILCEPVEGEFEKNIETLGREWFTLEELPVLSEDKTTKEQIAMCFEAAADKDWKVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGN5</accession>
    <name>F7KGN5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254915.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05014"/>
    <dbReference type="EnsemblBacteria" id="EGN33809">
        <property type="protein sequence ID" value="EGN33809"/>
        <property type="gene ID" value="HMPREF0994_05014"/>
    </dbReference>
    <dbReference type="GeneID" id="29726511"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5477"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020013_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356629" evidence="2">
        <location>
            <begin position="22"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="802" mass="88553" checksum="4824E6F2B21D5E59" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGZ0</accession>
    <name>F7KGZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33153.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360059.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05120"/>
    <dbReference type="EnsemblBacteria" id="EGN33153">
        <property type="protein sequence ID" value="EGN33153"/>
        <property type="gene ID" value="HMPREF0994_05120"/>
    </dbReference>
    <dbReference type="GeneID" id="29726241"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364042" description="DUF3502 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="2">
        <location>
            <begin position="357"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33153.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="498" mass="56028" checksum="C962F56460D3AC4C" modified="2013-09-18" version="2">MKKKGIVFVMVFMMLFLTSCKNGETEISGSTPTELHIVYSSYSGIPEDLEIVQDALNKILIEKINCTVNLEVYPSSNYDTQINLLLSGGDGIDLMTSGLNTRYHQIVSKKLVLPIDDLLEKYGKGIMDAVGDSLEAGRINGILYGVTGVPLTAAADTGFAVKNKILNELDINLQEVKTIEDVEIVLKKIKEKYPDMTPLIPSSSGRAYDDLSNYMWRSDEMESIEDGCIVDYETMTVSNLYESETFKKTVELLYRWNKEGLIMPNASTNSDTRGALLDGNQGVAYLTTSYSPTLSAKENLQLDVDIVELDQNKILGTSSFTNTQWMIPVKSKHPEEAMKFLNLLYTDEEVGNMLQYGIEGVHYVKTDKENVITYPEGQDVVNSRYYVKTPGITDININCYAIEPLPGDIYQKYQEFKNEFKQSPLLGFMADVSECKTETAAIANVIAQYHFNFMSGDYDTSMLNEMNEKLKDAGINKVIEVKQRQLNEWLEVNKNENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGZ5</accession>
    <name>F7KGZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255029.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05128"/>
    <dbReference type="EnsemblBacteria" id="EGN33161">
        <property type="protein sequence ID" value="EGN33161"/>
        <property type="gene ID" value="HMPREF0994_05128"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5605"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="28333" checksum="6C53FF3E4AE934F6" modified="2011-09-21" version="1">MKENKYDDPLFFEKYSQMDRSKKGLDGAGEWKTLENMLPDFQGKKVLDLGCGYGWHCEYAADHGAAEVTGVDISEKMLEEARKSHKKGNTTYICCPIEDIDFEEASFDIILSSLAFHYIENYEEIVDKIHKLLKPGGYLVFSAEHPVFTAEGSQDWYYDENGKILHFPVDNYYYEGKRNAVFLGEPVTKYHRTFTTYISVLLKKGFRLVDVEEPQPPEEMLNTVPGMKDEMRRPMMFLVSAQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH41</accession>
    <name>F7KH41_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255076.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05177"/>
    <dbReference type="EnsemblBacteria" id="EGN33210">
        <property type="protein sequence ID" value="EGN33210"/>
        <property type="gene ID" value="HMPREF0994_05177"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5656"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091992_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="29363" checksum="9B0D4C4E08D3955C" modified="2011-09-21" version="1">MLKLIKCEFLKLKRKKFIPLVILSAFMFPIPLTYLMTTPSMMERYTDKADAFDGLFNMVLGYGIQFLLPCIIGVIAAMLFFMERDNDTFKNLRTIPVTSTQMVLAKIFVLFLFGIIFCVASTIATILCGLGTLEVYGLGYKLFLAVETGIFITAGTLPLIVLVVFFSKTYVFSILLCVFYSVLNMSATALFDALPKTILWFLPTPLTTFWSAGDMAAHGIKMDLEQMTGLIPSTFQVVMILGIMAIISFWLIDRLYKQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHT1</accession>
    <name>F7KHT1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32861.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360085.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05420"/>
    <dbReference type="EnsemblBacteria" id="EGN32861">
        <property type="protein sequence ID" value="EGN32861"/>
        <property type="gene ID" value="HMPREF0994_05420"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="167"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32861.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="374" mass="41761" checksum="C1B5E8F9AE325A9C" modified="2013-09-18" version="2">MAVIKKKNTDVSKEEEIYMETQWQLMWRKFRKHKLAMLGGIILILLYTVGIFSEFFATQDIAKRSTLAISMAPTQIHFVDAEGNFSIQPFVYGLKQEEDPVTWKKYYVEDTTVKHKLRFFYKGDSYKLLGFIPGDIHFFGTPEPDVYFPFGTDASGRDLYSRVLSALRISLSTGLVGVFFTFVLGCLFGGISGFYGGVTDTIIQRVIEFLMSMPSIPLWMALAAAFPTTWSSLKIYFAITIILSLIGWTTLARVVRGKLLELRNEDFVTAARVSGATDGYIIVKHLLPSFSSYLIVNVTLAIPSMILAETSLSFLGIGLTPPIVSLGVLLQDAQSINTVSMYPWMMIPGIFVVISVLAFNFVGDGLRDAADPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI09</accession>
    <name>F7KI09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571036.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05511"/>
    <dbReference type="EnsemblBacteria" id="EGN32952">
        <property type="protein sequence ID" value="EGN32952"/>
        <property type="gene ID" value="HMPREF0994_05511"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6025"/>
    <dbReference type="eggNOG" id="ENOG5032UJY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195077_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025468">
        <property type="entry name" value="TTRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041965">
        <property type="entry name" value="TTRAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14203">
        <property type="entry name" value="TTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="71" mass="8153" checksum="78B6010C9CFEBE21" modified="2011-09-21" version="1">MGNFTFEEMNLMCIYNTGSRTGLMEALTEMRGELSPEETELRELTDSALMKLQAMSDAEFSQLELYPDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI55</accession>
    <name>F7KI55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05534"/>
    <dbReference type="EnsemblBacteria" id="EGN32474">
        <property type="protein sequence ID" value="EGN32474"/>
        <property type="gene ID" value="HMPREF0994_05534"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6050"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="15850" checksum="3EB7D1CD2ECADB4B" modified="2011-09-21" version="1">MDVKHALTACEDLKTVRQRLQVLDDLGLGYLTLGEETPSLSGGEAQRLKLASEMGRQQEGTVFVFDEPTIGLHPLDVRTLLTVFDRLVECGATVLVIEHDLDVISNADYVIDMGPGGGMDGGRIVAVGTPDEVAANPRSITGKYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIT9</accession>
    <name>F7KIT9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_rep_org_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000013">
        <property type="protein sequence ID" value="EGN31909.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006555734.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05768"/>
    <dbReference type="EnsemblBacteria" id="EGN31909">
        <property type="protein sequence ID" value="EGN31909"/>
        <property type="gene ID" value="HMPREF0994_05768"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055973_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010056">
        <property type="entry name" value="Phage_rep_org__N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09681">
        <property type="entry name" value="Phage_rep_org_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01714">
        <property type="entry name" value="phage_rep_org_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_rep_org_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31909.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="28296" checksum="0746B9F7CA5C0C64" modified="2013-09-18" version="2">MADNRKYYYLKLKENFFDSDSIVLLEDMKDGILYSNILLKLYLKSLKNGGKLQLDEHIPYTAQMIATLTRHQIGTVERALEIFRQLGLVEQLDSGAFYMTDIELMIGQSSTEAERKRAARLENKALLPPRTKGGHLSDIRPPEIEIELEKEIEIEKEREGETGHPAPAAYGRYNNVILTDTELSGLKTELPDKWEYYLDRLSCHIASTGKQYHSHAATIYKWAQEDAAKGKAAPKQGIPDYSCKEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ59</accession>
    <name>F7KJ59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05891"/>
    <dbReference type="EnsemblBacteria" id="EGN31519">
        <property type="protein sequence ID" value="EGN31519"/>
        <property type="gene ID" value="HMPREF0994_05891"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6444"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="198"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="829" mass="96394" checksum="A4DF9A0EA7999EA1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ64</accession>
    <name>F7KJ64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05896"/>
    <dbReference type="EnsemblBacteria" id="EGN31524">
        <property type="protein sequence ID" value="EGN31524"/>
        <property type="gene ID" value="HMPREF0994_05896"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SDJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1018581_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="27830" checksum="B8FC6AD20F5522CC" modified="2011-09-21" version="1">METIAYQLTTCSGLIVSPRSALAFYRDLDEFSLEKVEDSEYLAKSRLKVIYPFYQYGIYTAYNPEGAAYYLPGSSVKGALCRGTSVEGGLMSDDILIPGSYIVLRNIYKVQYLEENTQACFAPFFDNVGVEMVRADSPLQGQLILPDRDSANALITAANKSAKIKIGQMLEYLSELAKREYKEEMTKKLHTIIENLSPYLENDHIILLGGYKGLLHSMEIKDPSAVTNSGVFIDPEKDLPYGLAEIEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ85</accession>
    <name>F7KJ85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255693.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05917"/>
    <dbReference type="EnsemblBacteria" id="EGN31545">
        <property type="protein sequence ID" value="EGN31545"/>
        <property type="gene ID" value="HMPREF0994_05917"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="221"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="324" mass="36459" checksum="2179038C38D7254A" modified="2011-09-21" version="1">MHHTNQALNELYQNLLINAPQTVSVEIPPDLGTGQITQTETKQGIVLSDWRMNYLSDMNVQGTNSPEYIQIIFCVGEGISWGTTNERYSVNIQKGESCIYNGCGKTESICYSQKRGFYFKSLKIPMRYFSSLLSDYFDNKELQSCEKKLFTGFSKVKITPSMERILAETRDFAHYHGGLGHLYLDGRISELLAVYLSEVLEMDMLSNNNALISATDRASLMEAKRIIDSQIAFAPSCQELSRLVHLSVTKLTKGFSQIFGMPVHTYIIDRRLSCAARLLLESDLNISEIAMAVGYAKPSNFAAAFRKKYGVVPKGYRKSQILDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJH7</accession>
    <name>F7KJH7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PTS_EIIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_06006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255782.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06006"/>
    <dbReference type="EnsemblBacteria" id="EGN31360">
        <property type="protein sequence ID" value="EGN31360"/>
        <property type="gene ID" value="HMPREF0994_06006"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6576"/>
    <dbReference type="eggNOG" id="COG3641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063648_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13303">
        <property type="entry name" value="PTS_EIIC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PTS_EIIC" evidence="9">
        <location>
            <begin position="14"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN31360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="355" mass="35846" checksum="DE853095AE974923" modified="2011-09-21" version="1">MEKVKKLCNRIFIDGLSGMAQGLFATLLVGTILEQVGTLIGGSIGAYIIVVATVAKKLTGAGIGIGVASKFKEPPLVTVSAAAAGMIGAYAKTIIGGTILTEGVFTLAGVGEPLGAFVAAYLAVEIGGLVAGKTKVDILVTPITTITVGSVVGLSIGVPIAAFMTKVGELINWGAVQQPFWAGIIVSALMGIALTLPISSAAIGVSLNLSGIAAGAAAVGCAANMVGFAVASFRENRTGGLVAQGLGTSMLQMPNIIRKPVIWLPAIFASIILGPISTCVFGMTNNATGSGMGTCGLVGQIMAFQTMTGDGMGAGPALFQIILMHVIAPAVLALLFSELMRKKGWIKPGDMKLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJL5</accession>
    <name>F7KJL5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255825.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06049"/>
    <dbReference type="EnsemblBacteria" id="EGN31403">
        <property type="protein sequence ID" value="EGN31403"/>
        <property type="gene ID" value="HMPREF0994_06049"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6622"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117108_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="153" mass="17530" checksum="E02CF551AF7781C1" modified="2011-09-21" version="1">MNILFFLTPKSEVAYVDENDSLRQVLEKMEHHGYAAVPLLSSGGKYIGTITEGDVLWKLKKEGFPELHEMEDISVMEMIRNRDNKPVHINVDMEGLMERIMKQNFVPVVDDDKVFIGIVTRKDAIQYLIDELKKKKYDGTAADKIKTMVQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJM0</accession>
    <name>F7KJM0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06054"/>
    <dbReference type="EnsemblBacteria" id="EGN31408">
        <property type="protein sequence ID" value="EGN31408"/>
        <property type="gene ID" value="HMPREF0994_06054"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6628"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590238_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="218"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="463" mass="52211" checksum="529131004145BE85" modified="2011-09-21" version="1">MENKEMTYLGKPVDWSREKAGDGYPLLLYAEDDGKRLHWDQEKYPCFFWQVSVDKDTEHMDIAEQMRALVEKYPVDVSRIYGAGAGKAANVIWEMMGAYPDLFAAVAVSGGAGQTWKVRRASYVPAWIFGRENDSYCPAGGQIWSDQGKLLHGCLTLVRSLRAAGNERVLYSPKPEMTGEELLEDKEAVQWMFVRSKREGYRIDMLRPGVWKLQDYTGSSFYVVEGTRAALVIDTGFGPELVTPWIRKITSLPLELALTHCHGDHMYHADEFKTVYLSAKEKEPLERMKKTMLAGRDIDYDSLQDIPDGTVIDLGGLGIEVMELPGHTPGSVLFIDHTHKVIFTGDAIGSGQMVLLQLAPVISLQEYKKNLERLYERLEDMDDYVLLGGHMEQEGGYPFGTPYNPSPYNPLGREVVQDMMELCDIFGSDKVKKEELSPDRMCEEPSFLGYFGKAGLCARSSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJM3</accession>
    <name>F7KJM3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255833.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06057"/>
    <dbReference type="EnsemblBacteria" id="EGN31411">
        <property type="protein sequence ID" value="EGN31411"/>
        <property type="gene ID" value="HMPREF0994_06057"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6631"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="329" mass="37039" checksum="3C9FF6A1BE1609E7" modified="2011-09-21" version="1">MASIRDVAQKAGVAISTVSKVLNQYPNVSEETKAKVNEAIRELNFTPNTIASALSSKQAGRVALLLNLNTQTQAIDEIDMQYISGAINKAQEMKLDVITVFFSMIKDRDVYGIVNYLKAQSIEGIIIYGMSREDKILHKLIEEQHFRIVVVDAPFVNPNTSSVQIDHEKAQYDVAKKTILENKGNKILYIAGKKNGFVTKDRLDGMKRLAEEEKLSLLVRQGDFSEKKARQLAFQYARNRDIVVCASDLMAIGAMRALQEMDIFRPVCGFDGITLMGYAGKQMNTVRQDFYRISAEAMEEMARLLEGGEGREILLDYSIIRMQYLDIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJR1</accession>
    <name>F7KJR1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255849.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06073"/>
    <dbReference type="EnsemblBacteria" id="EGN31427">
        <property type="protein sequence ID" value="EGN31427"/>
        <property type="gene ID" value="HMPREF0994_06073"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_36_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="162" mass="18596" checksum="AE1D4CC9E58ABE3D" modified="2011-09-21" version="1">MNSEKKITVREGDWDDFWILRDGIGEEQHIHAMNRPDIFADLEESPFGPEDFRLIMEDENSFFLVAEVDGKAAGMCNVKLKKAPVHPVVLPRRYAYIDDICILPDFRHMGVGKALYDALAERIRPMGIRKVELKVWAFNESAMGFYEALGMKPQNIIMEGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJW8</accession>
    <name>F7KJW8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30650.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360020.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06157"/>
    <dbReference type="EnsemblBacteria" id="EGN30650">
        <property type="protein sequence ID" value="EGN30650"/>
        <property type="gene ID" value="HMPREF0994_06157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="364"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30650.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="460" mass="52087" checksum="3795A4E2DBCC0800" modified="2013-09-18" version="2">MFRVIIADDENRVVKMLVSSIPWTKLGLSVEGTASDGREALRQAKENHADIILTDIRMPGLNGLELCEELHKNNSNIQIILISGYADFTYAQKAIQLGVLGYCLKPVDTKELTKLLRQAVRNIRRESSLHSDILLDYIEEEEEEPLRRLLGTFGLSGDSLYLAASVHMPDCGEELEAGLTVKLGRRKYLYFSEKPFNRDAACRLISDNREKAGISLSFLPSPLNRLKERVTETEIMAYQFFISASSCLMEVPVSASLTEELFRRLQEAQSSPETLLAFLHDLKGRDCSLLLDIAGAYRLYNLVYACPFMGAPEEDGEYFLNGYEQLAEDYSSFSEVLEEMEERLRTPAPVLSQPQSVSQASSFMQIIKYLNENYEKDVSLKKLSELFHLNASYVSFLIKNETGLTYSQYLTELRIGKARELLTTTDLSLAEISEAVGFHDYFYFIKKFKKVVGVTPGHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK06</accession>
    <name>F7KK06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06195"/>
    <dbReference type="EnsemblBacteria" id="EGN30688">
        <property type="protein sequence ID" value="EGN30688"/>
        <property type="gene ID" value="HMPREF0994_06195"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030QZQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076321_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041273">
        <property type="entry name" value="DUF5596"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041644">
        <property type="entry name" value="GNAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18164">
        <property type="entry name" value="GNAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18082">
        <property type="entry name" value="NAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAT_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GNAT_C" evidence="2">
        <location>
            <begin position="108"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="30824" checksum="6E22DBBF316A57D5" modified="2011-09-21" version="1">MGEAADKMLSLPISEEEYTRNRELYRQDYFAFCDRIKEKEDFRIWMLAYLCRFACDTYDVYVERNIAEKIFWDTFRDITYWCENCLRDYGEYGINEYGWFWRHLKLTLFRLGRLEFEILEADHDITGILEGKAYKIPKGTPIINVHIPQGDPLVKEDCEKSFQQAFAWFGTEKPYLCHSWLLYPKLRELLKPESNIVRFQELFTLLDMDMEGTEAEQRIFGEVLSDPAGYPEKTGLQKAAKKFLMEGKKLGNGLGIHLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK35</accession>
    <name>F7KK35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255985.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06209"/>
    <dbReference type="EnsemblBacteria" id="EGN30702">
        <property type="protein sequence ID" value="EGN30702"/>
        <property type="gene ID" value="HMPREF0994_06209"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6801"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1308815_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="210" mass="23675" checksum="BB43B5CB44A9AC7C" modified="2011-09-21" version="1">MLHLPENLKKYRLLKNLTQEDVAEYLGITAQSVSKWERGESYPDITFLPALANIFETSVDLLIGMDTIRAEETRYNIHKKAVAYQRCGDYNSAEQTYRDALLIYPNKPGMILGLASTLALKGNTNEAIELMERGLPLSSNEKQKATMRAALCFLYLKAGREDSANRLASELPHTRESREVIQPLIQQGLSEMEIDENIKTIILGDGKGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK59</accession>
    <name>F7KK59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256014.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06238"/>
    <dbReference type="EnsemblBacteria" id="EGN30507">
        <property type="protein sequence ID" value="EGN30507"/>
        <property type="gene ID" value="HMPREF0994_06238"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6836"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="30995" checksum="1A209050D48C827D" modified="2011-09-21" version="1">MNHKFWRAFRFYLISCLLAVIVMVPFLWMLSTSLKSKGALMEIPIRWIPENPTMDAYRKVFSKFPFLRAIFNSFFITTSYTLITILSASMAAFAFTKIRFPGADGLLKLYLASMMIPTQVTLIPLFVIMNKLGLINTYPSVILPSLFRVFGIFMLVQQMRSIPNDFMEAARIDGAGMFRIFRVVILPLCGSSIATLTITTFMESWNDYLWPLLMLTDKNKMTLTLALNNLNGQYGTEYNVLMAGSLISMLPIIIVYACAQKNFKQGVMAGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB0</accession>
    <name>F7KKB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator, peroxide stress response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256059.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06289"/>
    <dbReference type="EnsemblBacteria" id="EGN30208">
        <property type="protein sequence ID" value="EGN30208"/>
        <property type="gene ID" value="HMPREF0994_06289"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6893"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="15077" checksum="FC1182B52C1070D6" modified="2011-09-21" version="1">MTLKYSRQREAIKDFLMTRKDHPTADVVYSNVRTEFPNISLGTVYRNLTLLADLGEIARLRVGDGVDHFDADTSPHYHFVCSDCGNVIDLDMDSIDYINQTAAKNFNGQITGHITYFYGLCPHCKEKKLKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKE4</accession>
    <name>F7KKE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002570941.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06323"/>
    <dbReference type="EnsemblBacteria" id="EGN48102">
        <property type="protein sequence ID" value="EGN48102"/>
        <property type="gene ID" value="HMPREF0994_06323"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6926"/>
    <dbReference type="eggNOG" id="ENOG50330KV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208973_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="61" mass="7406" checksum="AA81BC98C3009DD8" modified="2011-09-21" version="1">MCTVKEIREAIREDCRSQHDMETADIDRIFQTLPFSQRNSLLDKPPMPKRPYRRRKKEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL04</accession>
    <name>F7KL04_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_06533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256295.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06533"/>
    <dbReference type="EnsemblBacteria" id="EGN47252">
        <property type="protein sequence ID" value="EGN47252"/>
        <property type="gene ID" value="HMPREF0994_06533"/>
    </dbReference>
    <dbReference type="GeneID" id="29729844"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7155"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="8">
        <location>
            <begin position="720"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN47252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="986" mass="113502" checksum="16C05ADF13CD6F69" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL68</accession>
    <name>F7KL68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006059569.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06601"/>
    <dbReference type="EnsemblBacteria" id="EGN47320">
        <property type="protein sequence ID" value="EGN47320"/>
        <property type="gene ID" value="HMPREF0994_06601"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7225"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="35409" checksum="372AB715D45FE61C" modified="2011-09-21" version="1">MKSSAKKIELASVDDLFSTEESRQDEQLEKIQEIPLSELHPFKDHPFKVKDDDAMIETADSIKKYGVLVPAIARPLPDGGYELVAGHRRRRASELAGKETMPVIVRDLDDDAATIIMVDSNLQRENLLPSERAFAYKMKLEAIKHQGARTDLTSVQVEQKLSARDQVAKEAGERSGIQVMRYVRLTELIPELLDMVDEKKIAFNPAYELSFLKPDEQQMLVETMDYEQATPSLSQAQRMKKFSQEGKLSEDVMLAIMSEEKKGDLDKVTLSSDTLRKYFPKSYTPAKMQETIIKLLEQWQKKRQRDQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS11</accession>
    <name>S2KS11_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360171.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07221"/>
    <dbReference type="EnsemblBacteria" id="EPC05072">
        <property type="protein sequence ID" value="EPC05072"/>
        <property type="gene ID" value="HMPREF0994_07221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002248_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="302"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="949"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1333" mass="153957" checksum="EF3758DE185EDA47" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSD3</accession>
    <name>S2KSD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05384">
        <property type="protein sequence ID" value="EPC05384"/>
        <property type="gene ID" value="HMPREF0994_07052"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179877_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="77" mass="8776" checksum="9D46885A94424A9E" modified="2013-09-18" version="1">MDKKKKTPKQIAALVCVGLLVLLYVVTLVVACLNFPGADRLFQACLVATVGLPILLWIYMWLYGKMKDRFKERDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSU9</accession>
    <name>S2KSU9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ORF">HMPREF0994_06990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359761.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06990"/>
    <dbReference type="EnsemblBacteria" id="EPC05322">
        <property type="protein sequence ID" value="EPC05322"/>
        <property type="gene ID" value="HMPREF0994_06990"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_9"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="323" mass="35076" checksum="A5C302F69D969C2B" modified="2013-09-18" version="1">MKNELLSIGPFTIYGYGLMIGIGIIAAYLTAESRAKKLKLDPDKIFGLVIWCLIFGYLGSKILFCITVIDKIIADPAYILHSLQNGWVVYGGLIGGIIGGCLYCRHKKVNFMPYFDLAVPSVALAQGFGRIGCFLAGCCYGQETSSPLGITFTYSDFAPNGVSLIPTQEISSLLNFLNFFILINIAKKKKAEGQVGGFYLIFYSIGRFILEFYRGDLERGNVGSLSTSQFIAIFTLIAGILLVVVPQMLANRGVKIFMVGPDGTALQDEKNGSEEKNGTEIASEKTELTEEAEVPEDTAEITEPEDNDSGEKTADDEEKGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWD5</accession>
    <name>S2KWD5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359699.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06953"/>
    <dbReference type="EnsemblBacteria" id="EPC05285">
        <property type="protein sequence ID" value="EPC05285"/>
        <property type="gene ID" value="HMPREF0994_06953"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="316"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="586" mass="67596" checksum="22FD92F9824179B5" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWG4</accession>
    <name>S2KWG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359778.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06998"/>
    <dbReference type="EnsemblBacteria" id="EPC05330">
        <property type="protein sequence ID" value="EPC05330"/>
        <property type="gene ID" value="HMPREF0994_06998"/>
    </dbReference>
    <dbReference type="GeneID" id="29725637"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000788_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021754">
        <property type="entry name" value="DUF3320"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025103">
        <property type="entry name" value="DUF4011"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11784">
        <property type="entry name" value="DUF3320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13195">
        <property type="entry name" value="DUF4011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="3">
        <location>
            <begin position="1373"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1910"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1911"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1930" mass="218981" checksum="E4C39D09A3BCB660" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAU1</accession>
    <name>S2LAU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="6">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_06984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359752.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06984"/>
    <dbReference type="EnsemblBacteria" id="EPC05316">
        <property type="protein sequence ID" value="EPC05316"/>
        <property type="gene ID" value="HMPREF0994_06984"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="8">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EPC05316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="320" mass="37335" checksum="5589128DF25AEA8B" modified="2013-09-18" version="1">MNFYFAPMEGITGYIYRRAYHSCFYPMDKYFTPFIAPKQDKTLNSKEKNDILPEHNEGMRVVPQILTNRAEDFIRTAEKLREFGYQEVNLNLGCPSATVVSKKKGSGFLGEREALDRFLENLFENLSMDISIKTRLGMDEPEEFYRLLEIFNKYPLKELIIHPRVQADYYRNSPDRKVFADALKISRNSVVYNGDIFSEGDYEQFTASFPETGAVMLGRGILANPGLPGRLCGKKQPSKQEIKQFLDRLVQDYREVLSGERDVLFRMKELWFYLGFLFTNPEKYVKKIKKAQRLCDYEEAVRTLFREQELAENGAFRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJJ6</accession>
    <name>S2LJJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360129.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07193"/>
    <dbReference type="EnsemblBacteria" id="EPC05138">
        <property type="protein sequence ID" value="EPC05138"/>
        <property type="gene ID" value="HMPREF0994_07193"/>
    </dbReference>
    <dbReference type="GeneID" id="29727998"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="44"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="262" mass="29429" checksum="3A369D932F3BDFD0" modified="2013-09-18" version="1">MAAFELVFLGTGAADWPLRPGADVRYDVNGVIRRTSSLLINGKYLIDPAPESWFFAKKVLKLDLSGLKGIFLTHSHKDHFTNKALDSFLGEAKGKVGFYCHEGTIPWLKLTQEEQERMNIHPLKIGKRVKAGDMTILPLGANHEVSRTQETALHYIFSGEGKSFFYGCDGAWFLAQTWSVLQKQKLDVMILEATVGNMRANYRIASHNTLPMVELLVASIEECEILKEDGRVVLSHMARELHSPEEEYGNMIAAYDGMKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2F0</accession>
    <name>F7K2F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249978.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00029"/>
    <dbReference type="EnsemblBacteria" id="EGN48262">
        <property type="protein sequence ID" value="EGN48262"/>
        <property type="gene ID" value="HMPREF0994_00029"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.32"/>
    <dbReference type="eggNOG" id="COG4474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108363_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06908">
        <property type="entry name" value="YpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="163" mass="19022" checksum="30B962C4FA3A3857" modified="2011-09-21" version="1">MKKKTCCVTGHRDLPQNQINYVKAALLREIEKSVADGFTCFMSGVAEGVDQYFVEIVMEKQKDDPSLELIAVIPYQKRLDSLRAKRRTYEMLEACRDVVVIQEEYQPSVYSHRNRYMVEHSDRVIAVYDGREKGGTVRTIRFAHQMKKELREIPVGEIYFPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2J9</accession>
    <name>F7K2J9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN48311">
        <property type="protein sequence ID" value="EGN48311"/>
        <property type="gene ID" value="HMPREF0994_00078"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033D1U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179132_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="74" mass="8649" checksum="D8F945016F28B0C1" modified="2011-09-21" version="1">MKKLYNILKIVLLCFIGVFIGSSIYQYHDYKTHPDIYVSQSAPWYVSIEIRGILTAIIVMAILITMWIIKKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2R0</accession>
    <name>F7K2R0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00139"/>
    <dbReference type="EnsemblBacteria" id="EGN42756">
        <property type="protein sequence ID" value="EGN42756"/>
        <property type="gene ID" value="HMPREF0994_00139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="567" mass="65437" checksum="BCE220D6A0F739E5" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2U6</accession>
    <name>F7K2U6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00175"/>
    <dbReference type="EnsemblBacteria" id="EGN40732">
        <property type="protein sequence ID" value="EGN40732"/>
        <property type="gene ID" value="HMPREF0994_00175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="193"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="298" mass="34216" checksum="FFD0C99A83565436" modified="2011-09-21" version="1">MNPNTQEPGPFSETYFHTPSPLAKKTFLYPVCLGHYYCDEEYCVARNNYDSFLMMLVVKGQGYAESLGEKAFRKKIGEKQLVLMDCYAPHMYGADSEMEFYWIHFDGINAGAYFRYLTEVYGTVLTLTDSQANVFLHKFRMLLEALSSDQGIAENLLGYFVTDLLTFPSGLTGARTVSGSEAAQEDRFTRELGKAVSYMRQHFMEEITIEDLADCVSVSPYHFIRLFKKQYGITPHQYLLSMRLDCARFYLRSGDKTVKEIAFSCGFQSENNFCVAFKKQTGMTPTNYRHGMETRELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3B7</accession>
    <name>F7K3B7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250299.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00350"/>
    <dbReference type="EnsemblBacteria" id="EGN33491">
        <property type="protein sequence ID" value="EGN33491"/>
        <property type="gene ID" value="HMPREF0994_00350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.379"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="27106" checksum="3EBDA66E838F5700" modified="2011-09-21" version="1">MILQLEHIQKNYGTKTVLKDCTFSFERGKIYGLLGRNGAGKTTLFNCLTDEVRADAGEAFLIDEDGSTKPLIPSQVGYVFSTPILPDFLTGYEFIRFYMDIHQGKRTPEKTIDEYFDMVKMDKEDRHKLIKGYSHGMKNKVQMLCFIIARPPVILLDEPLTSFDVVVALEIKQLLRELKQDHIIIFSTHILQLATDLCDEIAVLSEGNLQQIDHNLLAGKDFEERIIELLKDDNAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3D9</accession>
    <name>F7K3D9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00372"/>
    <dbReference type="EnsemblBacteria" id="EGN33513">
        <property type="protein sequence ID" value="EGN33513"/>
        <property type="gene ID" value="HMPREF0994_00372"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_10_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="15002" checksum="C04642E0DE7E7DAA" modified="2011-09-21" version="1">MEKEDNQPDEKQRKKKEEKMLNLEIGGRLKEFRKNGKYTQEQFAEVLEVNVEHYRKLENGKYALSLKKLETLSKKYNLNLDYLITGTKDSREFNVEAYLANCDRDQRNDFIERVLIYMKNLMLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Q1</accession>
    <name>F7K3Q1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN48198">
        <property type="protein sequence ID" value="EGN48198"/>
        <property type="gene ID" value="HMPREF0994_00480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.528"/>
    <dbReference type="eggNOG" id="ENOG502Z8F8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062029_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="127"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="337" mass="37950" checksum="4CC0718DBB6AB37A" modified="2011-09-21" version="1">MKQIIQDFFQEDTVTIVGSGLSLAEGIPGMAGLAVELQSKIPHKLSDKLDLGIWRSISSDLTSGTSLEQALQRNKPSEYIEECIRKTTAEFIGKAELKVFENVVNSNYELRFEEYLKRFNIRNSGLTVITTNYDRLVEYACEHQGIRIDTLFVGKYFARFLPEQSKYAFCSNITKRAGKSVALFAPKVTILKPHGCLSWHMIDGEPYSIPGYPMKDCLIITPGINKYKEGYSVPFDTHRNKANAAIDFAQKYIIIGYGFSDDHLETHLVQQLKSGKPALILTHSLSDKAELIVKSSKRVIAICNSGTEDSKVITSAEEHVFPKLNLWDLHTMLKEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3R5</accession>
    <name>F7K3R5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00494"/>
    <dbReference type="EnsemblBacteria" id="EGN48212">
        <property type="protein sequence ID" value="EGN48212"/>
        <property type="gene ID" value="HMPREF0994_00494"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.543"/>
    <dbReference type="eggNOG" id="ENOG502Z83H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738199_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="150" mass="16774" checksum="109225BB9EBA0D49" modified="2011-09-21" version="1">MIELSYHLVLEDGAVETVPMGVFEISEANRTIRCLEIKAYDHMLRFEKSFNGFETVGNAYAFLALCCKACKVELAHTQAEIEAMPNGSEMLSVYTENDIETYRDVLFYVGQVLGGFFCINREGKLELRKYGNQFHEHQDADGGVLCAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3T2</accession>
    <name>F7K3T2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00511"/>
    <dbReference type="EnsemblBacteria" id="EGN45515">
        <property type="protein sequence ID" value="EGN45515"/>
        <property type="gene ID" value="HMPREF0994_00511"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.560"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN45515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="212" mass="24586" checksum="DD04635E9F3CDD26" modified="2011-09-21" version="1">MAGRKKEALVQFHKKSILDTAEKLFSEKGIRQTTMDDIAKAADYSKSTLYVYFKSKDEIYEHIIYSHMCRLKESMEECTRENLDFEQCYFRICAKLSQLYEQYPLYFPSILGNIPVDDQSLADSEILHLIYDVGEEINDCITEIFRQGIREGILSPDINILPSAFTLWAALGSLIPMANEKECYLKKRMNMDKSEFLQHSFRMLLQSLKGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K400</accession>
    <name>F7K400_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliW</name>
        <name evidence="4" type="ORF">HMPREF0994_00580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250529.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00580"/>
    <dbReference type="EnsemblBacteria" id="EGN44768">
        <property type="protein sequence ID" value="EGN44768"/>
        <property type="gene ID" value="HMPREF0994_00580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112356_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="17184" checksum="FAB1757EAE65E492" modified="2011-09-21" version="1">MKADTMYFGMLEFNKEELICFEEGLFGFENRKDFLPVPFEAEDDTILCLQSIEDRDTSFIIMNPFRLSPDYNPQLKPEDYKRLGTSREEDLSYYVICVIRNTPEESTVNLKCPVVVNSVTRKAIQVILEDGNYRFRHSLSEFSGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4D8</accession>
    <name>F7K4D8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250666.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00717"/>
    <dbReference type="EnsemblBacteria" id="EGN44066">
        <property type="protein sequence ID" value="EGN44066"/>
        <property type="gene ID" value="HMPREF0994_00717"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.777"/>
    <dbReference type="eggNOG" id="ENOG5033M9T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801822_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357080" evidence="1">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="135" mass="15094" checksum="2B5657197D90DDD0" modified="2011-09-21" version="1">MKALKKIFRPCFALAMIIIFLTGCGQLNTVESLVVSNEPYAAKEDIEDAVQPEQVSAGTDIYASIYFIESPKGMEYTGKWYLNGEEIKSDTQETITDKSGAVIYRLEADDVKKGSLQFEVFYNNELLSSTELTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4J9</accession>
    <name>F7K4J9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250727.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00778"/>
    <dbReference type="EnsemblBacteria" id="EGN43487">
        <property type="protein sequence ID" value="EGN43487"/>
        <property type="gene ID" value="HMPREF0994_00778"/>
    </dbReference>
    <dbReference type="GeneID" id="29726051"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.845"/>
    <dbReference type="eggNOG" id="COG4823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044962_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011664">
        <property type="entry name" value="Abi_system_AbiD/AbiF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07751">
        <property type="entry name" value="Abi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="92" mass="10914" checksum="5E6027D0A9C64E93" modified="2011-09-21" version="1">MAKPFLTYDQQLDKLINGKKLCITDCEKAKEILRDIGYFSLIGGYKTPFINPMTRVYEDNTAFEDIYALYQFDLALRELVFKYLCQIERKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4T1</accession>
    <name>F7K4T1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250809.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00860"/>
    <dbReference type="EnsemblBacteria" id="EGN43412">
        <property type="protein sequence ID" value="EGN43412"/>
        <property type="gene ID" value="HMPREF0994_00860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.938"/>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046973_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="469" mass="51771" checksum="2BE9E3DC7592DD38" modified="2011-09-21" version="1">MEQKYDVIIIGAGPGGIFCAYELMEKNKDLKVLMVEKGRPIEKRTCPKRKTKVCVGCKPCSITTGFAGAGAFSDGKLSLSPDVGGNLPEILGYEQTKELIKESDNIYLKYGADTRVYGMDKEKEIREIRREAINANLKLVECPIRHLGTEEGYKIYSRLQDALAEKGVEMMFHTMVEEILVEDGRAAGIVTDKGDTYLADEIVSAVGREGADWFKDKCAQIGIATTPGTVDIGVRVEVRDEVMQFLNENLYEAKLIFYTPTFDDKVRTFCTNPSGEVAAEYYEGGLAVVNGHAYKSQDYKTSNTNFALLVSKNFTKPFSTPIEYGRKIAELSNMLCGGKILVQTFGDFRRGRRTTEERLCRNNLIPTLKDAVPGDLSLVFPHRIMVDIAEMIEALDKVTPGIASDETLLYGVEVKFYSNKVVVDKDFETSIKGLRAIGDGAGVTRGLQQASANGISVARSILQSMGNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4V5</accession>
    <name>F7K4V5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 4">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250833.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00884"/>
    <dbReference type="EnsemblBacteria" id="EGN43193">
        <property type="protein sequence ID" value="EGN43193"/>
        <property type="gene ID" value="HMPREF0994_00884"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.964"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_5_2_9"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="166" mass="19082" checksum="610FA8099EA2987D" modified="2011-09-21" version="1">MNIIVAVDENWAIGCRGDLLVRIPADHRMFRNETLGKVVVLGRKTMDTFPGGLPLQGRTNIVLTRNPDYQVKDAVAVHSVEELLEEVKKYDSRDVYVIGGDSVYRLLLPYCDTAHVTKIDRAYEADAYFPNLDEDGEWEITADSEEQTYFDTTYHFVKYERKKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Y6</accession>
    <name>F7K4Y6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00915"/>
    <dbReference type="EnsemblBacteria" id="EGN43224">
        <property type="protein sequence ID" value="EGN43224"/>
        <property type="gene ID" value="HMPREF0994_00915"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1000"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107893_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009501">
        <property type="entry name" value="UCP020269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020269">
        <property type="entry name" value="DUF1121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="211" mass="23139" checksum="E4BCBEC15976A060" modified="2011-09-21" version="1">MDNRQKAFVKACDGIIANLKKRNMEGYFYEDSASCVRAILDMIPDGSSISWGGSASVQESGMMDALKNGSYELIDRSLAKTPEEQREIYGRTIMSDYYFMSTNAITYEGELVNIDGNGNRVACLIHGPRHVIIIAGMNKVTTTLEGAFERARTMACPPNAVRLDKKTPCAATGKCGNCLSPDCFCNQIVVTRRSGHTGRIKVFLVAEDLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5C9</accession>
    <name>F7K5C9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251007.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01058"/>
    <dbReference type="EnsemblBacteria" id="EGN43031">
        <property type="protein sequence ID" value="EGN43031"/>
        <property type="gene ID" value="HMPREF0994_01058"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1159"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068049_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN43031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="28329" checksum="F27321FE81FA2906" modified="2011-09-21" version="1">MILFFSGTGNSEYVAERIGKDIGDTVLNLFEKIRKQDYSALQSDKPWIVVTPTYAWRMPRIVTDWLRKTELMGSRDIYFVLTCGGDIGNAGAFLRRFCMEKGLEDQGCASVLMPENYIALFETPSEEEALALIERAEPKITDIARMIKEGRILPEQQISGKDKISSGLVNTVFYPLMVHAGKYYATDACISCGLCEKVCPLGNITLKDGKPVWGKNCTHCMACICRCPKEAIEYGKHSQGQPRYVCPKGNSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5J5</accession>
    <name>F7K5J5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251073.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01124"/>
    <dbReference type="EnsemblBacteria" id="EGN42886">
        <property type="protein sequence ID" value="EGN42886"/>
        <property type="gene ID" value="HMPREF0994_01124"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1233"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325905_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="861" mass="97795" checksum="E32F64C1AEA78C1C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5M6</accession>
    <name>F7K5M6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251111.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01162"/>
    <dbReference type="EnsemblBacteria" id="EGN42924">
        <property type="protein sequence ID" value="EGN42924"/>
        <property type="gene ID" value="HMPREF0994_01162"/>
    </dbReference>
    <dbReference type="GeneID" id="29726825"/>
    <dbReference type="eggNOG" id="ENOG5033E7M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488095_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="589" mass="66954" checksum="4CCE7C8DB06D53A9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5N2</accession>
    <name>F7K5N2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251117.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01168"/>
    <dbReference type="EnsemblBacteria" id="EGN42930">
        <property type="protein sequence ID" value="EGN42930"/>
        <property type="gene ID" value="HMPREF0994_01168"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2841967_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="68" mass="7903" checksum="D2A474CE9F12E45C" modified="2011-09-21" version="1">MKIMDKKVMHKRFGMGSVIGLKDNKIYVSFGKIFGDKALPYPEVFASDMKMMDEDLQEELMEDIGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5V7</accession>
    <name>F7K5V7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_01236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42483.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359966.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01236"/>
    <dbReference type="EnsemblBacteria" id="EGN42483">
        <property type="protein sequence ID" value="EGN42483"/>
        <property type="gene ID" value="HMPREF0994_01236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="10"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN42483.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="312" mass="32739" checksum="14F39D626960B157" modified="2013-09-18" version="2">MANIKKSAEELIGRTPLMELVNYEKKAGVTDAVILAKLEYFNPAGSVKDRIALQMILDAEEEGLLKPGATIIEPTSGNTGIGLAAMAAARGYKAILTLPETMSVERRKLLKAYGAQIVLTPGAEGMKGAIAKAEELHREIPGSFIPGQFDNPSNAKAHKLTTGPEIWEDTDGKVDIFVAGVGTGGTLTGVGGYLKEKNPDVKVVAVEPAQSAVLSGKKPGSHAIQGIGAGFVPGVLDTEIYDEIIQVENEDAYSTGRAIAHTQGLLTGISSGAALHAATLLAKRPENKGKVIVVLLPDSGDRYLSTPLFSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6H5</accession>
    <name>F7K6H5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251432.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01483"/>
    <dbReference type="EnsemblBacteria" id="EGN41957">
        <property type="protein sequence ID" value="EGN41957"/>
        <property type="gene ID" value="HMPREF0994_01483"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1617"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_2_9"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="3"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="31141" checksum="8F3D2D9C593B8AC2" modified="2011-09-21" version="1">MKKIIVTGCNGQLGRAVNLFFKDNKDISFVNTDVGELDITNIDKVMELAREVQPYAIINCAAHTGVDACETEYDKAFKINAIGPRNLSIAARETGAKLMHISTDYVFDGKGTRPYVETDATNPQGAYGSTKLAGENFVKDFADRYFILRTAWLYGDGKNFAKTMLRLSETNEKVRVVGDQFGSPTSASELTKAINALLFTENYGMFHATCEGSCSWAEFAREVFRLAGKTTKVEAITTEEFGAPAPRPAYSILENRMFKLTTDFMFADWHDAIAEYMKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6K7</accession>
    <name>F7K6K7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator, ferric uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251466.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01517"/>
    <dbReference type="EnsemblBacteria" id="EGN41991">
        <property type="protein sequence ID" value="EGN41991"/>
        <property type="gene ID" value="HMPREF0994_01517"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1655"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="158" mass="17938" checksum="C27280E21C020AB3" modified="2011-09-21" version="1">MTLDEEKIRGILKEKGLKVTRQRLLVLDTLASRPGSHLTAEEIFDLVKGDSPEIGLATVYRTIQLFMELHLIDRINLDDGFVRYEIGDMGTKKNSHHHHHLICLSCGRVMSVEDDLLEELEAEIARTTGFKVTDHEVKLYGYCKECGGNLIEKNKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6K8</accession>
    <name>F7K6K8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251467.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01518"/>
    <dbReference type="EnsemblBacteria" id="EGN41992">
        <property type="protein sequence ID" value="EGN41992"/>
        <property type="gene ID" value="HMPREF0994_01518"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1656"/>
    <dbReference type="eggNOG" id="ENOG5032YV4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146610_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="86" mass="9824" checksum="D3CB60AD3ED06E41" modified="2011-09-21" version="1">MDKIEFSLENGEKTEFYVLEQTRLGGCDYILVTDTVDEEEGEALILKDISAPEDKDAIYEIVDDERELDAVAEIFSDMLDDIDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6P5</accession>
    <name>F7K6P5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251504.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01555"/>
    <dbReference type="EnsemblBacteria" id="EGN42029">
        <property type="protein sequence ID" value="EGN42029"/>
        <property type="gene ID" value="HMPREF0994_01555"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_12_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="155" mass="18004" checksum="D06E36804E4ECE9F" modified="2011-09-21" version="1">MTTDEMRSALLRTTFRYGKVNMGIRLGNITHGEFITLQMVHRYMKNHPDEHGIGVSELARCSYMSPPAMSRTLKSVEEKGLAVRMVDKKNRRKTYVCLTDEGEDARLQAWKTCTDYIDWVLKEMGEEKMETFLELWGELVDLMEKNIPVFYGEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K754</accession>
    <name>F7K754_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251596.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01683"/>
    <dbReference type="EnsemblBacteria" id="EGN41721">
        <property type="protein sequence ID" value="EGN41721"/>
        <property type="gene ID" value="HMPREF0994_01683"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1837"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_7_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="29788" checksum="E9A178DEEF1F4D82" modified="2011-09-21" version="1">MAVIKGLEWTFDTAAEVYEKMRPGYVEELYQDIFQYIPVDESSNVVEIGIGGGQATPPVVKTGCKLTAVEYGEALSEICREKFKEYPRFSVATLKFEDYVCEPDSCDLIYSASAFHWIPEETGYRKVFEMLKSGGAFARFANHPYKDKGREDIHEALQRIYAVYMPNSSAPEEYSDADAKRRAEIAYKYGFTDIFYKLYHRTRTFTANEYITLLGTYSDHIAIEEKTRMKFFSEIKDAINGLGGQITIYDTIDLQLARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K778</accession>
    <name>F7K778_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251620.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01707"/>
    <dbReference type="EnsemblBacteria" id="EGN41745">
        <property type="protein sequence ID" value="EGN41745"/>
        <property type="gene ID" value="HMPREF0994_01707"/>
    </dbReference>
    <dbReference type="GeneID" id="29727761"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_47_13_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="63" mass="6675" checksum="0587DC32D2048ED8" modified="2011-09-21" version="1">MLEGKTAVVTGGIREMMEPIINAIPLGRMGQPENIASTFLFLSSDMPSYITEAVLSVDGAAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K789</accession>
    <name>F7K789_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251631.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01718"/>
    <dbReference type="EnsemblBacteria" id="EGN41684">
        <property type="protein sequence ID" value="EGN41684"/>
        <property type="gene ID" value="HMPREF0994_01718"/>
    </dbReference>
    <dbReference type="GeneID" id="29728091"/>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439914_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="621" mass="69470" checksum="4E4CCEC4B42FC465" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7A1</accession>
    <name>F7K7A1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="10" type="ORF">HMPREF0994_01730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01730"/>
    <dbReference type="EnsemblBacteria" id="EGN41673">
        <property type="protein sequence ID" value="EGN41673"/>
        <property type="gene ID" value="HMPREF0994_01730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1889"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="149"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="420"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN41673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="449" mass="51553" checksum="63B2DBA2EEDEB1AF" modified="2011-09-21" version="1">MMTAFETIQAETVPTDNENNFPAEGRPQEGLNREITIHGSVHKIRKMSGFSFLILRTSDRLIQCVLDTGKCRVEGSLKEEACIRARALVVEEPRSKTGWELHLTELEVLSAPEEEMPVVINGKGIDASLETLLDYRPLTLRNEKQRAIFKIQEGLCRGFRAFLEKEEFTEVHTPKIVYQGAEGGANIFRLDYFGKDAYLAQSPQFYKQMMVGVYERVFEIGPVFRAEKHDTARHLNEYTSVDFEMGYISSFRDICRMEAAMIKSSLAWLQSHYEKELALLKVRIPEAGSIPSIRFHEAKDLIAARYNRPLCEKNDFEPEEEKLLCEIVKKETGSDFVFVTHYPSAKRPFYAMEDEENPEVTLSFDLLFRGLEVTTGGQRIHDFRQQLAKMERMGMDPSLFESYLWIHKAGMPPHGGLGLGLERFTARLLELENVRQAALFPRDIHRVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7C5</accession>
    <name>F7K7C5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="10" type="ORF">HMPREF0994_01754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251667.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01754"/>
    <dbReference type="EnsemblBacteria" id="EGN41567">
        <property type="protein sequence ID" value="EGN41567"/>
        <property type="gene ID" value="HMPREF0994_01754"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1915"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN41567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="96" mass="11414" checksum="4082923D5F4E1B8C" modified="2011-09-21" version="1">MKKQLTYNYAFVFYDVNEKRVQKVFKICKKYLSHFQFSVFRGEITPSKLIELKTELNKIINKNEDFICIIKLMNNNVFGEEILGKRDEVTGEDLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7C6</accession>
    <name>F7K7C6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CRISPR-associated endonuclease cas1, subtype I-b/hmari/tneap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41568.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01755"/>
    <dbReference type="EnsemblBacteria" id="EGN41568">
        <property type="protein sequence ID" value="EGN41568"/>
        <property type="gene ID" value="HMPREF0994_01755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN41568.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="220" mass="26393" checksum="6C5CAD440FEF07FC" modified="2013-09-18" version="2">MSEILYHYYKHDKKEVKDTIDWLKKEFPSRVDTAVKPAELMAYEGEAWSKFYGTFKYFLPEDFIMNKRVKRPPDNPINAMISFGNTLLYTKTISAIYRTHLDQRISFLHEPAEARFSLSLDISEVFKPVIVYRTIFELVNNRRLQVDKHFDKKVNYCLLNEEGRKIFVEAFEQRMETVFMHSRLKRKVSYRTAIKLDCYKLIKFILEDEKFVPFSLKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7M7</accession>
    <name>F7K7M7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">HMPREF0994_01921</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251834.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01921"/>
    <dbReference type="EnsemblBacteria" id="EGN41326">
        <property type="protein sequence ID" value="EGN41326"/>
        <property type="gene ID" value="HMPREF0994_01921"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2105"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="144"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="37584" checksum="8F0DFA920B5CB2F0" modified="2011-09-21" version="1">MKIVVLGGGISTERDVSLSSSRMIYEALKKKGHQAILLDVYLGYEGDYEDIFEKNIDWAENIGGITESNPDISSIKALRKDGGKSFFGPGVIPVCQMADVVFLGLHGEDGENGKVQAAFDLLGIRYTGTDYVSSALAMDKSLAKELFAFHSIPTPAGTHLKKGEESTQRVPFPCVVKACRGGSSVGVCIAHDEKEYQAALEEAFRYDEEAVIEQYIQGREFSCAVIDGKALPVIEIAPLTGFYDYKNKYQAGSTIETCPADLPKEKAEEMQAISEKVFAALRLKQYARMDFMMDGDGKLYCLEANTLPGMTPTSLIPQEAQAMGVSFEDLCEWIMELALKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7V4</accession>
    <name>F7K7V4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="11" type="ORF">HMPREF0994_02000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251913.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02000"/>
    <dbReference type="EnsemblBacteria" id="EGN41405">
        <property type="protein sequence ID" value="EGN41405"/>
        <property type="gene ID" value="HMPREF0994_02000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2196"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="33537" checksum="316FCDE6F2DAB7A4" modified="2011-09-21" version="1">MASMRDIKRRKGSIQSTQQITKAMKLVSTVKLQKAKTKAEESKPYFDTMYQTVKSILGMSENIRHPYLDGGTGSKKGVIVITSNRGLAGGYNSNITKLLTRGDLPKEDVVVYAVGKKGKDALERSGYHIAADYSEVMDEPSYHDAMHIGRRVLEAFEQGEIGEIYLAYTVFKNTVVHIPVMNRLLPVSAEPSSSEKDSASGVSDSGTVTGEKAAGQKEGFTGPEAPMNFEMEEVDALDLLIPKYITSMIYGGLLEASASENGARMQAMDSATSNAEDMIDDLTLAFNRARQSSITQELTEIIAGAQAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K853</accession>
    <name>F7K853_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41507.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360141.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02102"/>
    <dbReference type="EnsemblBacteria" id="EGN41507">
        <property type="protein sequence ID" value="EGN41507"/>
        <property type="gene ID" value="HMPREF0994_02102"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029523_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41507.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="517" mass="57657" checksum="13E5B66AA4C16B55" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8I5</accession>
    <name>F7K8I5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">HMPREF0994_02169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252082.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02169"/>
    <dbReference type="EnsemblBacteria" id="EGN41076">
        <property type="protein sequence ID" value="EGN41076"/>
        <property type="gene ID" value="HMPREF0994_02169"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2374"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="208"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="22"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN41076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="397" mass="41719" checksum="88171A9DDE5453C6" modified="2011-09-21" version="1">MLEIKTNDAESAAKIIVVGVGGAGNNAVNRMIDEKIDGVDFVGVNTDKQALQLCKAPKLLQIGEKLTKGLGAGAKPEIGAKAAEESTDEITNALTGSDMVFVTCGMGGGTGTGAAPVIAGIAKKMGILTVGVVTKPFRFEARTRMTNALNGIERLKDSVDTLIVIPNDKLLEIVDRRTTMPEALKKADEVLQQAVQGITDLINVPAVINLDFADVQTVMKEKGIAHIGIGHGKGDDKASEAVKMAVESPLLETTIAGATDVIINVSGDISMYDADDAASYVQQLTGDDVNIIFGAMYDDSTPDTCQITVIATGLDDKPQQAQNKFGSQFSVKPQQSPVKPVQPGMGTRPYTPVSPAPAAGTKPVAPAPNYTGIHKPGNLRSNVEEKSLKIPDFLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9A2</accession>
    <name>F7K9A2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine/putrescine transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02448"/>
    <dbReference type="EnsemblBacteria" id="EGN40847">
        <property type="protein sequence ID" value="EGN40847"/>
        <property type="gene ID" value="HMPREF0994_02448"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2682"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_18_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="58"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="30222" checksum="17E050B00787EBEA" modified="2011-09-21" version="1">MNNKKYRHLLSGPYIFWSVAFIIIPLCMVFYYGLTDKTGAFTLANVAAIASAEHSKALWLSIALSLISTLICFLLAYPLAMILANMNVNQHSFIVLIFILPMWMNFLLRTLAWQTLLEKTGVINSILAFLHLPSLNIINTPAAIVLGMVYNFLPFMVLPIYNVLVKIDPNVVNAARDLGANGLQTFLRVTFPLSLPGVISGITMVFVPALTTFVISNLLGGSKILLIGNVIEQEFTQASNWHLGSGLSIVLMIFIILNMIITSVFDKEGEGQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9V3</accession>
    <name>F7K9V3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-glycero-alpha-D-manno-heptose-7-phosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252537.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02636"/>
    <dbReference type="EnsemblBacteria" id="EGN40619">
        <property type="protein sequence ID" value="EGN40619"/>
        <property type="gene ID" value="HMPREF0994_02636"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2891"/>
    <dbReference type="eggNOG" id="COG2605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048558_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="Galkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014606">
        <property type="entry name" value="Heptose_7-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036406">
        <property type="entry name" value="Hept_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="88"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="228"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="328" mass="36597" checksum="E09A6EC0052896F9" modified="2011-09-21" version="1">MIITRAPFRVSFCGGGSDLPCFYEKYGGCVLSTTIRKYMYLTIHNYFYKDQIVLKYSKTEIVKDYSEIEHKIFKQCLSDFEIKGVEISSMADIPAGTGLGSSSTFTVALLHLLYTYKGDYVSKYKLAKDACEVEIEKLGEPIGKQDQFAAAFGGLKYYEFLPGGFVNVSPIIMTSDSYSKLEENLMMFYLGGTHSASKILKEQSKNITQIKKATVQQKMCNLTRILKDELQKNNVDAMGELLHENWLLKKSLASGISTPIIDDIYDRAIKAGASGGKLLGAGGAGFLLFYVPQDKHTSVREALSNFREMNFEMDNSGASIVQVDRDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA18</accession>
    <name>F7KA18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252602.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02701"/>
    <dbReference type="EnsemblBacteria" id="EGN40684">
        <property type="protein sequence ID" value="EGN40684"/>
        <property type="gene ID" value="HMPREF0994_02701"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2956"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022800_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="91"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="676" mass="75809" checksum="494CBCA4777E035D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA39</accession>
    <name>F7KA39_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">M16C_associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252623.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02722"/>
    <dbReference type="EnsemblBacteria" id="EGN40705">
        <property type="protein sequence ID" value="EGN40705"/>
        <property type="gene ID" value="HMPREF0994_02722"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2978"/>
    <dbReference type="eggNOG" id="COG1026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M16C_associated" evidence="1">
        <location>
            <begin position="462"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="972" mass="111468" checksum="D9F3B5E9160833D9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA51</accession>
    <name>F7KA51_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_02737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252638.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02737"/>
    <dbReference type="EnsemblBacteria" id="EGN40720">
        <property type="protein sequence ID" value="EGN40720"/>
        <property type="gene ID" value="HMPREF0994_02737"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2994"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_9"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="191"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="382"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN40720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="538" mass="59547" checksum="8716B958E6C87AA4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA67</accession>
    <name>F7KA67_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02917"/>
    <dbReference type="EnsemblBacteria" id="EGN40526">
        <property type="protein sequence ID" value="EGN40526"/>
        <property type="gene ID" value="HMPREF0994_02917"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3184"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_41_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="103" mass="11674" checksum="2CAE127865397CE4" modified="2011-09-21" version="1">MLWADKDRLFAFTKHFMRHEMLRGCKVSGVKVIRVHDTRHSHASLLIEMGLSPLLIADRLGHEKVQTTMDTYSHLYPSKQAEVATKLDILMGTVADSQNVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAD1</accession>
    <name>F7KAD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252658.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02757"/>
    <dbReference type="EnsemblBacteria" id="EGN40366">
        <property type="protein sequence ID" value="EGN40366"/>
        <property type="gene ID" value="HMPREF0994_02757"/>
    </dbReference>
    <dbReference type="GeneID" id="29724622"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3016"/>
    <dbReference type="eggNOG" id="ENOG5032YW0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050652_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021338">
        <property type="entry name" value="DUF2953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11167">
        <property type="entry name" value="DUF2953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="38753" checksum="4BE7CEA47F81C8B5" modified="2011-09-21" version="1">MGVVISILKILGIILLVILAVLILALLVVLFVPVRYRAKGEVPAEGNPHGIVRVTWLLHLASFRLEYDSGKYENSFHWDFRILGIPFRLKQRAAVPKKKTETAEEEAETAVKEKTEGKEKPEGKANPEGKEKPAVPVQTLKEEPQVSGQKRPDEAGTVPGGESRTEQIKDSGGREKEKASFFTRICNKIHSFFDNLKKSFQNIRYTITRLCDKIKRILDNLEYYREILSRKDSLLVMGKVKGQAGRLLKHALPQKTNVNFIVGTGDPASTAQILAIHGILYPVIGETVHISPDFEEARLEGDFDIRGRVRIAVVLDVVLRIILDKKTWRFIRQLKKEEMTNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAQ3</accession>
    <name>F7KAQ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252780.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02879"/>
    <dbReference type="EnsemblBacteria" id="EGN40488">
        <property type="protein sequence ID" value="EGN40488"/>
        <property type="gene ID" value="HMPREF0994_02879"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3148"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="28812" checksum="31E3FFBB0D1B31FC" modified="2011-09-21" version="1">METELKVAVCDDSQADRNILSQLVKKTAEDMGIPVHIQEYASGENLMEDILSEHDILFLDIQMEGMDGQETAFAFRSQNRNAVLVFVTGVAVPTPEMFKVYPYRYLLKQELLSKGREDMSAILKKAAERKKHVYLTAFYKGKMMQLDSDRILYISLKKRGCQIWLNQEKDESPINCNSRLADIYAGLEMHNFAYAHNSYIVNLKYVAKVEGNLLVLMDGTALTISRSRKEEFHKAFARYLGNKYPKKQYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB05</accession>
    <name>F7KB05_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BMC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252935.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03034"/>
    <dbReference type="EnsemblBacteria" id="EGN40211">
        <property type="protein sequence ID" value="EGN40211"/>
        <property type="gene ID" value="HMPREF0994_03034"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3314"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="3">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="120" mass="12382" checksum="1D96DA0658FB2B12" modified="2011-09-21" version="1">MGKSYGLIEITGVTAAVDALDIMCKAAEVTLATWERKLGGRLVTIIVEGDVAAVTAAVEAAAHAIKPLVASGVIANPHEEIVGLVKRSSSRFMTASKEAGAEAENPAGGMLSEESYLQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB06</accession>
    <name>F7KB06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propanediol utilization protein PduA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03035"/>
    <dbReference type="EnsemblBacteria" id="EGN40212">
        <property type="protein sequence ID" value="EGN40212"/>
        <property type="gene ID" value="HMPREF0994_03035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3315"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="91" mass="9123" checksum="A27B65AB3AF6CF9C" modified="2011-09-21" version="1">MAQEALGMIETRGLTAAIEAADAMTKSAEVTLVGTEKIGSGLVTVMVRGDVGAVKAAVESGSAAAGKLGELVAAHVIPRPHSDVEKILPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBZ0</accession>
    <name>F7KBZ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253270.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03369"/>
    <dbReference type="EnsemblBacteria" id="EGN39876">
        <property type="protein sequence ID" value="EGN39876"/>
        <property type="gene ID" value="HMPREF0994_03369"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3682"/>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084703_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="205" mass="22140" checksum="945CFDA8FFAAB2DA" modified="2011-09-21" version="1">MKLEEYAPGEIEKRSFAIIEEELGRELDPVQKPIIKRVIHTTADFSYADTLFFSEGAVEEGLNALRSGVSIVTDTNMGKAGINKKKLGQLGGSVHCFMADEDVAEKASRLGITRAAVSMEKAAEMQEDFIFAIGNAPTALIRLYELIKEGRIHPRLIIGVPVGFVNVVEAKELILTAGVPVIVARGRKGGSNVAAAICNALLYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC11</accession>
    <name>F7KC11_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ORF">HMPREF0994_03390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253291.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03390"/>
    <dbReference type="EnsemblBacteria" id="EGN39897">
        <property type="protein sequence ID" value="EGN39897"/>
        <property type="gene ID" value="HMPREF0994_03390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3705"/>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="196" mass="21797" checksum="4A061E838C0383AC" modified="2011-09-21" version="1">MDKKRIIVGISGASGTPLALELLRQLEGCREQTETHLIYTDGAVQTLRRETGQKPEQLEKMADYVHDSHNIGAAPASGSFRTDGMIVVPCSMKTVAGIASGYSDNLLLRAADVTLKERRRLVLVTRECPLSSIHLRNMYELSRMGAVILPPVLSFYNHPDSLDCCVKHITGKILDLFGMEGEGYHRWEGMDEDFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC57</accession>
    <name>F7KC57_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39948">
        <property type="protein sequence ID" value="EGN39948"/>
        <property type="gene ID" value="HMPREF0994_03441"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3761"/>
    <dbReference type="eggNOG" id="ENOG502ZG8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2615717_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="85" mass="9647" checksum="ED791DC1FA983135" modified="2011-09-21" version="1">MNDVKAVKVFTAQDNLQAEMVLDTLKRNQIPAYKKDVDESGFMNIYAGNSMCGEEIYVAQKDEEKTMEILREMGLEPEKAPGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC75</accession>
    <name>F7KC75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253355.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03454"/>
    <dbReference type="EnsemblBacteria" id="EGN39527">
        <property type="protein sequence ID" value="EGN39527"/>
        <property type="gene ID" value="HMPREF0994_03454"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3775"/>
    <dbReference type="eggNOG" id="ENOG502Z91S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441306_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043751">
        <property type="entry name" value="DUF5696"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18952">
        <property type="entry name" value="DUF5696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="639" mass="73306" checksum="11D64D7F249F86B6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCA5</accession>
    <name>F7KCA5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253385.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03484"/>
    <dbReference type="EnsemblBacteria" id="EGN39557">
        <property type="protein sequence ID" value="EGN39557"/>
        <property type="gene ID" value="HMPREF0994_03484"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3810"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="164"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="32228" checksum="3AD99AA1ADAB5B26" modified="2011-09-21" version="1">MKVLIVDDEELTREGIRMSIPWENLGITEVYMAEDGEEGLKKALELLPDIILADVRMPRMDGITMAFEIRKSWKQCRFIFVSGYCDKEYLKSAIQLSAVNYIEKPVEPSEIVDALKKSILQLEEEKRRLAIEEEYRTHFKGVLEEIPEEDLVPVSWQSSMHMADKIEHYIQENFADINLSLTQLADAFELTKQYMCWLFKKEKNETINQCIIRTRLKWAKEYMRRNPFVKIKNVAAKAGFADSSYFIKIYKKYEQVTPADYLRECNENRPEAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCC8</accession>
    <name>F7KCC8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253397.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03496"/>
    <dbReference type="EnsemblBacteria" id="EGN39569">
        <property type="protein sequence ID" value="EGN39569"/>
        <property type="gene ID" value="HMPREF0994_03496"/>
    </dbReference>
    <dbReference type="GeneID" id="29728527"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="145"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="326"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="448"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="801"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN39569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="875" mass="98998" checksum="E94E2EB049FC3DCE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCD7</accession>
    <name>F7KCD7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253417.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03516"/>
    <dbReference type="EnsemblBacteria" id="EGN39425">
        <property type="protein sequence ID" value="EGN39425"/>
        <property type="gene ID" value="HMPREF0994_03516"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3842"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_8_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="7">
        <location>
            <begin position="396"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="8">
        <location>
            <begin position="493"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN39425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="695" mass="77938" checksum="A7D0406535A86E4D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCF8</accession>
    <name>F7KCF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253438.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03537"/>
    <dbReference type="EnsemblBacteria" id="EGN39446">
        <property type="protein sequence ID" value="EGN39446"/>
        <property type="gene ID" value="HMPREF0994_03537"/>
    </dbReference>
    <dbReference type="GeneID" id="29728314"/>
    <dbReference type="eggNOG" id="ENOG5033W01">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699778_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="399" mass="46398" checksum="F5FFAD801B4C8CF0" modified="2011-09-21" version="1">MNTKQPFDPKEILNSIELPDDLDRLIGDSVEKGYERMRRKTKIKKVSMVRRAAVIAGIIAAGCLAAIPVKAWVSSLVQERMEQVPAEEQKELENVMDSQTVNADTYSREYTQDEKARDAELRKAYAGGTFPESELRQEKTADETLADVLYYAQDNSVFHLPERELTDEELLQIIDFQTKRDYVLSQRTSQEYEEQRREAREEIAAEGGIMEEKAIELGKEWLNRLYGITGEGMELNHYPDTDGDRNSYNVNFSIQSHEYYYFLLDSRNGELIHAMNSIADDLDREPLAVSVLEDKKDALYRMAEDYLVSRLGKEKDYERVVYSYRDKDGLLDNFNHIFFYFIKADGSAYEMRMNVEREAFSDFQMIDNYEEYVENLNKIGESNAAQNRKGKLVYKDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCW7</accession>
    <name>F7KCW7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recA</name>
        <name evidence="11" type="ORF">HMPREF0994_03696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253597.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03696"/>
    <dbReference type="EnsemblBacteria" id="EGN38860">
        <property type="protein sequence ID" value="EGN38860"/>
        <property type="gene ID" value="HMPREF0994_03696"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4034"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN38860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="36710" checksum="C09372856B16EC72" modified="2011-09-21" version="1">MDENKKKALDAAVMQIEKDFGRGAVMRLGDTSAFGEVEVVPTGALSLDIALGLGGVPRGRVVEIYGPESSGKTTVSLHMAAEVQKRGGIAAFIDAEHALDPKYAAGIGVDIDELYISQPDTGEQALEIAEMLVRSGAIDIIIIDSVAALVPKAEIDGEMGDSHIGLQARLMSQALRKLTPVVSKSRCIVVFINQLREKIGIMFGNPETTTGGRALKFYASVRLDVRRIDMIKSGGERIGNRTRVKVVKNKIAPPFKEAEFDIIYGTGISREGDILDLAADIDVVGKSGSWYSYQGSRIAQGRDAAKIFLKEHPEIMAEAEAKVREHYQLKPDTVSLSGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCZ3</accession>
    <name>F7KCZ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253623.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03722"/>
    <dbReference type="EnsemblBacteria" id="EGN38886">
        <property type="protein sequence ID" value="EGN38886"/>
        <property type="gene ID" value="HMPREF0994_03722"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4062"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="318" mass="35863" checksum="3BFE7C90232A40B3" modified="2011-09-21" version="1">MRKKRETTKLLQNRGNSARKAVRRENLQLYAMMLPVFILIAIFAYGPMFGLVISFQDYMPGSPFWGEGVTWVGLEHFKRFIEGKYFGRLIRNTLVLSGLNLLFGFTAPILFALLLDQIRWLRFKKFAQTASYMPYFISTVVVAGMVISFINEDGMITRFLHAVLDLPEQNWRNVGRAFPIIYTVVNVWKGFGFGSILYVSTISSIDQSQYESARIDGANRWQQCIYITLPGIRNIIAINLIMAIGGILGTNSDLILLLYSPATYDVADVIGTYTYRLGIIGGEYSYTAAAGLFMSVIGFVLTFIANKVSNKMTGYGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD01</accession>
    <name>F7KD01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253631.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03730"/>
    <dbReference type="EnsemblBacteria" id="EGN38894">
        <property type="protein sequence ID" value="EGN38894"/>
        <property type="gene ID" value="HMPREF0994_03730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4072"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027430_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="4">
        <location>
            <begin position="33"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5597" evidence="5">
        <location>
            <begin position="397"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN38894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="524" mass="59386" checksum="468D66253CD214AA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD40</accession>
    <name>F7KD40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253670.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03769"/>
    <dbReference type="EnsemblBacteria" id="EGN38740">
        <property type="protein sequence ID" value="EGN38740"/>
        <property type="gene ID" value="HMPREF0994_03769"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4112"/>
    <dbReference type="eggNOG" id="ENOG5031MST">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124959_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="182" mass="21317" checksum="4FAA74D6FC9035E1" modified="2011-09-21" version="1">MALKEVYDYFHSYDKQTYQVVACMGNEPSEEDVKDFESQYKIKLPVEFRKFTMSPLGGLYMEVREEIWPRAKQYDIGPFWSFCRGIIVYGIADEIPDFLDIRKKTKELHDDGFTDYIPFLSIVGNGDEIFCFDKDNNIVLLDYYTTGEAVPVEGTFSDCLMKQIEELEERKNMKIRGEDKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD79</accession>
    <name>F7KD79_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03808"/>
    <dbReference type="EnsemblBacteria" id="EGN38779">
        <property type="protein sequence ID" value="EGN38779"/>
        <property type="gene ID" value="HMPREF0994_03808"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4149"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="316" mass="35604" checksum="B948438214725163" modified="2011-09-21" version="1">MKTKVKTRQPGKRGTFGHYFKAHWQLYMMVAFPVIMLAVFSYAPMYGILLAFKNYRIVDGIWGSPWAAHFGMDNFIRFFNNYNFMESLRNTLVISLYTLVVNTPCAIILALSLNYVRKVKFKKFVQMVTYLPYFISTIVFVGILNAIFDTRVGAVGSFFYDKMGMNILGTPQLFSSVYVWSGVWQTVGYGSIIYIAALAGVDMEQHEAAIIDGATLLQRIRYVDLPAIMPTAVIMLILEIGRILNMGYEKILAMQNQNNLSVSEVIPTYAFKVSLVSSFPDYSYATAIGLFQSMVGLILILLSNKIAKKLTGDGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDB6</accession>
    <name>F7KDB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253747.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03846"/>
    <dbReference type="EnsemblBacteria" id="EGN38611">
        <property type="protein sequence ID" value="EGN38611"/>
        <property type="gene ID" value="HMPREF0994_03846"/>
    </dbReference>
    <dbReference type="GeneID" id="29729640"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="221" mass="25273" checksum="F10C2327829E0763" modified="2011-09-21" version="1">MEKKSLKTAPPVLSASLREIEDGLAFLQDARREDILVEQCRIRGLTAENEDFYKLNLEGVVFENCSFFHCNFEKASFIDVQFRNCDFSNSVLDDCYFNRCEFLFVKGVGTDFHESLLKETRWEECSLSFANFSGSRWESASLAGCDMQESYLADCRFKKVEWKDLNLKRASFFHTSLKGMDLRGNDVEGIIVSEEKNELRGAVADIYQAADLAKLMGIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDJ9</accession>
    <name>F7KDJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_03944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253845.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03944"/>
    <dbReference type="EnsemblBacteria" id="EGN38709">
        <property type="protein sequence ID" value="EGN38709"/>
        <property type="gene ID" value="HMPREF0994_03944"/>
    </dbReference>
    <dbReference type="GeneID" id="29729314"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="351"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN38709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="603" mass="69104" checksum="58B6B70043F49344" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KED1</accession>
    <name>F7KED1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254111.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04210"/>
    <dbReference type="EnsemblBacteria" id="EGN36490">
        <property type="protein sequence ID" value="EGN36490"/>
        <property type="gene ID" value="HMPREF0994_04210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017624_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="168"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN36490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="817" mass="93523" checksum="7AF911154D6E0EDC" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KES1</accession>
    <name>F7KES1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxypyruvate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254251.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04350"/>
    <dbReference type="EnsemblBacteria" id="EGN35660">
        <property type="protein sequence ID" value="EGN35660"/>
        <property type="gene ID" value="HMPREF0994_04350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4750"/>
    <dbReference type="eggNOG" id="COG2379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="295"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="406" mass="43543" checksum="4ED4DD6101469C08" modified="2011-09-21" version="1">MREDAYKIIKETLADCLPDKAVRDALEKLQLSGRVYVAAIGKAAWVMAKTAADFLGNRLEKGIIITKYDHSRGALDKFEIIEAGHPTPDENSILGAKRAMELVKEGKEGDTVLLLLSGGGSSLVELPMPGLTLSDIQEVTKQLLFCGAGITEINVLRKKLSAMKGGKFAAYLKAAKVYSIILSDIIGDNDDMIASGLTYPDESTVNEVKKIINKYHLSLDRRVEKVLLSSQPCRDINIENHVVGSVKDLCYAAAVHARELGYSTHILTTSMQGEAREAGRWIASMYKEAYPRPFALIAGGETVVKVTGRGMGGRNQELALSAAGVIKDQKNVLLFSLGSDGTDGPTDAAGGIVDGCTAGKLEAVGMDVEEILQENDSYHALQKVDGLIMTGATGTNINDVTVLLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEY2</accession>
    <name>F7KEY2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254319.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04418"/>
    <dbReference type="EnsemblBacteria" id="EGN35728">
        <property type="protein sequence ID" value="EGN35728"/>
        <property type="gene ID" value="HMPREF0994_04418"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4824"/>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN35728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="422" mass="44292" checksum="9B7E46124BCB8B39" modified="2011-09-21" version="1">MGEKTMRQKLILGIQHTLAMFGATVLVPALTGLNTSITLFCAGLGTLLFHWITKKKVPVFLGSSFAFMAGIMAIIGDSRMGDPDFMDKLASVKGSLIIAGLVYVLFAGLIKIFGYEKVNKLLPPIVTGPIIIVIGLRLSSTAISSAFYYNGEFSLKAVLVTAVILTVVICVSIFAKGIFNLMPILFAIIAGYLVCLPLGFCDFTAVREAHFLSFMDKDIMAQLLCIPKFRADAILAIAPIALVTMIEHVGDITTNGAVVGKNFMVDPGIHRTILGDGLATALAGLLGGPANTTYGENTGVLAVTKVYDPSVIRIAAVFAMILGIFGKFGGFITSIPSPVTGGISIVLYGMISAVGVRILINSRLNFGNSRNLLVAAIILVLGIGCDSIPVYGAVTISGLALAAVVGIILAFILPEGEDSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF69</accession>
    <name>F7KF69_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254413.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04512"/>
    <dbReference type="EnsemblBacteria" id="EGN35822">
        <property type="protein sequence ID" value="EGN35822"/>
        <property type="gene ID" value="HMPREF0994_04512"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4928"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="426"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="530" mass="61282" checksum="23A82A22917192D2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFP8</accession>
    <name>F7KFP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254578.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04677"/>
    <dbReference type="EnsemblBacteria" id="EGN34888">
        <property type="protein sequence ID" value="EGN34888"/>
        <property type="gene ID" value="HMPREF0994_04677"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5108"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="32829" checksum="C346F0E78AB89782" modified="2011-09-21" version="1">MRKYKTWSNFLFDSVVVLLLLIFGLSCLIPILHVVALSLSSKTAALAGRVYLWPVEFTITPYKVLVTDAKFMQALWVSVKRVVLGGGLNLILTVITAFALSQEEKDFPGRKVYMWFLVFAMLFGASLVPWYFVIKATGLMDSIWALVVPGALPVYNTILLMNFFRNLPKEIKESAILDGISPVQMMLRICVPLALPAIATVTVFSIVGHWNNFFDGLLLTNTPSKMPLQTYIQTLTNKNIDVSSSSLTPEELEVLTSLKTFNAAKIVAASLPIVVFYPFMQRFFVSGLTLGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFT0</accession>
    <name>F7KFT0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254610.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04709"/>
    <dbReference type="EnsemblBacteria" id="EGN34635">
        <property type="protein sequence ID" value="EGN34635"/>
        <property type="gene ID" value="HMPREF0994_04709"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5141"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="35071" checksum="CB22DAE97C978859" modified="2011-09-21" version="1">MIDSKLITLLTVNELHSFTQTAKKLSLTQPAVSQHVRQLEKELGVTIFTRGEGNLKLTREGEIVIKYAKRIDSLYQNLEQSLKEEKEHARKITVGITHTSESNIMVEVLARYSSVSKKTRITIISDTINNLYMKLKTYEIDLAIVEGRISDSNFNAIMLDTDSLILAVSNKNPLSRKSMVTLNELKKENLILRLPDSGTRNLFISHLESNNVSLDEFNVILEVDNVATIKDLVRRDFGVSILARSACANELKKGKLIGLPIENLSMTREINMVYHKDFEHMDLLQNIMRIYNEYSLSNPHSVDTPGQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG04</accession>
    <name>F7KG04_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheD</name>
        <name evidence="4" type="ORF">HMPREF0994_04783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254684.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04783"/>
    <dbReference type="EnsemblBacteria" id="EGN34410">
        <property type="protein sequence ID" value="EGN34410"/>
        <property type="gene ID" value="HMPREF0994_04783"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5225"/>
    <dbReference type="eggNOG" id="COG1871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087854_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="158" mass="17248" checksum="D76EF3DFCF0DAB02" modified="2011-09-21" version="1">MDKISVGIGEGKTAVNQQILISYALGSCVGVCMYDRDKKIAGMAHIVLPGKESAVSRENPYKFADEGVKELIREMERAGASRKRITAKIAGGAKMFETASRQWEIGEQNVAAVKLALEKEGIRLVAENTGKNYGRTILFFAGDGKLEVRTVRQETVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG06</accession>
    <name>F7KG06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254686.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04785"/>
    <dbReference type="EnsemblBacteria" id="EGN34412">
        <property type="protein sequence ID" value="EGN34412"/>
        <property type="gene ID" value="HMPREF0994_04785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5227"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_16_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="314"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="558" mass="60628" checksum="57BF32F9475F052F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGS7</accession>
    <name>F7KGS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254957.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05056"/>
    <dbReference type="EnsemblBacteria" id="EGN33765">
        <property type="protein sequence ID" value="EGN33765"/>
        <property type="gene ID" value="HMPREF0994_05056"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033A80">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1755669_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="17097" checksum="8AF2FDE9F69CEA61" modified="2011-09-21" version="1">MKTKGKVVFLLGMLALTAGLLLAYRISERNSYLRIIRANWQTDLPYGCRQLYEIDSGKSFHGDGERYHVFLYDERKEQPVLEDGSLLSGASKERVIEILDSLGADKDWYPYFEKVTGKKIYRKQDGSVMYLLYEGGERKLYVVEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH34</accession>
    <name>F7KH34_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255069.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05170"/>
    <dbReference type="MEROPS" id="C40.007"/>
    <dbReference type="EnsemblBacteria" id="EGN33203">
        <property type="protein sequence ID" value="EGN33203"/>
        <property type="gene ID" value="HMPREF0994_05170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5650"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_12_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356640" description="NlpC/P60 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="210"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="334" mass="36773" checksum="982284B4F34EE6C4" modified="2011-09-21" version="1">MKLRHLFFACSGVFVMMFSLLLLVVIVFSDEEDGGSGGNLIYGGVSVSQEVLAHKPMLEKYAREYGIEEYLNVLLAIIQVESGGTLEDVMQSSESLGLPPNSLSTEESIKQGCKYFSELLAAAETKGCDLNSVIQSYNYGGGFLDYVAGRGKKYTFELAESFARDKSGGKKVTYTNPVAVEKNGGWRYSYGNMFYVLLVSQYLTVAQFDDETVQAIMEEALKYEGWTYVYGGDSPSTSFDCSGLVQWCYGKAGIALPRTAQEQYNVTQHIPLSEAKAGDLVFFHSTYNAGTYITHVGLYVGNNRMYHAGNPIGYADLTGSYWQQHLAGAGRIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH43</accession>
    <name>F7KH43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05179"/>
    <dbReference type="EnsemblBacteria" id="EGN33212">
        <property type="protein sequence ID" value="EGN33212"/>
        <property type="gene ID" value="HMPREF0994_05179"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5660"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089592_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="139" mass="16581" checksum="8518C694EB2EA831" modified="2011-09-21" version="1">MKPSEFQTTIENQFDYICKVAMEDERKDYLKALSRQCKRETLFCDMDDYTVNLFSSEDTYPSHFHTFEMDGFTVRIENSLLAEALENLDGKKRDVILRYYFLGFDDTEISKILEVNRSTIQRRRHAGLEFIKKFMEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHC8</accession>
    <name>F7KHC8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">P-loop_TraG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862398.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05267"/>
    <dbReference type="EnsemblBacteria" id="EGN33300">
        <property type="protein sequence ID" value="EGN33300"/>
        <property type="gene ID" value="HMPREF0994_05267"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5753"/>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009097_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-loop_TraG" evidence="1">
        <location>
            <begin position="447"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="799" mass="90922" checksum="6B082E05B0241227" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHF7</accession>
    <name>F7KHF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255129.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33021">
        <property type="protein sequence ID" value="EGN33021"/>
        <property type="gene ID" value="HMPREF0994_05286"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5771"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="452" mass="49430" checksum="525939D85E64FFA5" modified="2011-09-21" version="1">MYRDLTKGNITKTIILFVLPMMAGNLLQQFYNIADTLIVGRFLGSNALAAVGSAYTLMTFLTSILLGLSMGAGALFSIYQGQGDTQRLKAAVLHAFGLIFVIAAVLNVGVYLFIDPIMAFLHVPKQVYPLMRDYLWIIFAGVGAAFLYNFFAGLLRAMGNSSVPLIFLSISACLNIGLDLLFVLVFGWGVKGAAGATVIAQYAAGLGITLYTFIRCKNFLPSRTDLRWNGHILREICSLSILTCVQQSVMNFGILMVQGLVNSFGPVIMAAFAAAVKIDSFAYMPVQDFGNAFSTFVAQNYGAGKEERIRIGIKKSVQLTLLFCIFVSAVVVLFARPLMLLFVQPQETEILAEGVKYLRIVALFYWGIGCLFLLYGFYRAVKRPGMSVVLTVISLGMRVLLAYLLSAFVGVTGIWAAIPVGWILADVAGLVYYRCHKKDLMKFTGPPLEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHI5</accession>
    <name>F7KHI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antibiotic transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255157.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05314"/>
    <dbReference type="EnsemblBacteria" id="EGN33049">
        <property type="protein sequence ID" value="EGN33049"/>
        <property type="gene ID" value="HMPREF0994_05314"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5805"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="32717" checksum="7FE56D7F1036C062" modified="2011-09-21" version="1">MNAVQINHITKDYGNSRGIFDVSLSVKKGEVYGFLGPNGAGKTTTIRHLLGFLKPEKGECRINGMDCFSQASLIQKNLGYLAGEIAFPEDFTGHGLLHFLADMKGIRDRSRMKELIDLLELDPSGKVQKMSKGMKQKLGIINAFMGNPEIVILDEPTSGLDPLMQNRFIDLILEEKKKGTTIFMSSHLFEEVERTCERTAIIRRGQIAAVEDMEGLKKKRSRDYIITLDSKKSADALQLPGYTITGREGASVTVAVKEDIPGLLSLLSSCPVRDMQIHTQSLEEIFMHYYGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHW7</accession>
    <name>F7KHW7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255301.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05458"/>
    <dbReference type="EnsemblBacteria" id="EGN32899">
        <property type="protein sequence ID" value="EGN32899"/>
        <property type="gene ID" value="HMPREF0994_05458"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5966"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="24447" checksum="52D99269E7E4020C" modified="2011-09-21" version="1">MEIVKADNLVKYYGSGDSLVKAVDHVGLSVRKGEFVAVVGTSGSGKTTLLNLLGGLDYADEGTVLVDGQDITRMKEEELTVFRRRNIGFVFQSYNLVTVLNVEKNITLPIRLDGNRVDEEYIGGITSALGISDKRKAFPNQLSGGQQQRVAIARAIAGKPSVILADEPTGNLDSRTSAEVMGLLKMTSTRFHQTIIMITHNEAIAQLADRTIHMEDGRIVGGTADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI48</accession>
    <name>F7KI48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05489"/>
    <dbReference type="EnsemblBacteria" id="EGN32930">
        <property type="protein sequence ID" value="EGN32930"/>
        <property type="gene ID" value="HMPREF0994_05489"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2033982_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="121" mass="13597" checksum="09F983860227B3FF" modified="2011-09-21" version="1">MKTNNKWTVKDVITTVLLTVLLIGIHFVVITVSMVNQFFNCVLSPGVSMFFSAPVYMLMVSRVNKRFVSLTYLTILGVFFLLTGNLFRFGRPTMRGGTMEAGILSQRKEINLRMGDGEPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI50</accession>
    <name>F7KI50_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571054.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05493"/>
    <dbReference type="EnsemblBacteria" id="EGN32934">
        <property type="protein sequence ID" value="EGN32934"/>
        <property type="gene ID" value="HMPREF0994_05493"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6007"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="281"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="534" mass="59558" checksum="9EEC69F5B153C098" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI65</accession>
    <name>F7KI65_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255351.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05544"/>
    <dbReference type="EnsemblBacteria" id="EGN32369">
        <property type="protein sequence ID" value="EGN32369"/>
        <property type="gene ID" value="HMPREF0994_05544"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6060"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="318" mass="34483" checksum="5D7F552301B98264" modified="2011-09-21" version="1">MIKTLKYIGKRILFMIPILLGVSLIIFLLSSLIPGTPVDAYINESTTPEQIAKLTEKFGLNEPLPIRYWNWLVSTLQGDLGNSFRSGQPVAEMIGERIGPTLLLAGLALAVSLLISTTLGVLAAWKPYSVIDYVASGMAFLGSGMPAFFLGLISIYLFSVRLGILPNSGMYTNAAAADLGDILRHMIQPVLVLAVTLSGSNIRQTRSAMLEVLGEDYILVSRAKGMKRNVILLKHAFRNALIPIVTSAGLTVTTLVGGAIVTEQLFGWPGMGTLLMTSIKFRDYPAIMGITLYITIGIMLVNLLVDIIYGLIDPRVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI74</accession>
    <name>F7KI74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255360.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05553"/>
    <dbReference type="EnsemblBacteria" id="EGN32378">
        <property type="protein sequence ID" value="EGN32378"/>
        <property type="gene ID" value="HMPREF0994_05553"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6069"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="34687" checksum="6A4DAEA3BDA66271" modified="2011-09-21" version="1">MNRNRKSLYKYRFLYLLALPAFAYLVINNYMPMVGLVLAFKNYSFAKGIFGSDWNGIKNFTYLFGSKWAGIMFRNTILYNLVFIFLGTAIAVFTAILLNEVRNVMAQKIYQILILIPYLVSTVLIGYLVFAFFSNENGFINKGIIEPLGGQKIDWYLTPEAWPFILVFVQMWRSFGFQSIVFFATIIGFDKSLYEAAVVDGASAWQQIKKITLPLLKPTVIILVIMSLGRMFSTDFGLFYQVPQDTGMLYEVTTTIDTFVYRALMTDHDIGRSLAAGFLQSVLGFIVVLVTNSIVRKVEPDSALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIR5</accession>
    <name>F7KIR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004607960.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN32243">
        <property type="protein sequence ID" value="EGN32243"/>
        <property type="gene ID" value="HMPREF0994_05754"/>
    </dbReference>
    <dbReference type="GeneID" id="29728141"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6292"/>
    <dbReference type="eggNOG" id="ENOG502Z8Z8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091595_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025359">
        <property type="entry name" value="DUF4263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14082">
        <property type="entry name" value="DUF4263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="29555" checksum="2E1ED77CCD546F2B" modified="2011-09-21" version="1">MKSIHTFDVFAPTDEQEEAMNKKRGGHYRRGKNKEMDYFIECATSLFPNNHYSRFTPIYDTTKEFYQLITSSDTTERAILNWIASNRAWNYLFGLLRHYYRTGHHDDNYIFPEFKIGSAYVADYLLIGNSSDGYQFVFVELEAPNGRITKEKGTRFGEVINKGIEQVRDWQMYIAANWNVIVAELEKHSFSNTKLPRQLYKYCPYQIYYAVIAGLRKDFENIRDRKLQLQNENNITLLHYENLIDVANEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIW6</accession>
    <name>F7KIW6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255571.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05795"/>
    <dbReference type="EnsemblBacteria" id="EGN31871">
        <property type="protein sequence ID" value="EGN31871"/>
        <property type="gene ID" value="HMPREF0994_05795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6337"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="495" mass="55587" checksum="A4EBAD9313FF249D" modified="2011-09-21" version="1">MKKGQIRDGIVMDVKFPNKGNVKLMPASADAEAKSSMKENGTEERICIQAEEKEEFCTVKNVLPRQHLSLMITKVRKGKGEGRVLQVLAPSPDEIQAPCPHFGNCGGCTYLALPYEKQLSLKEKQVKELLDSVLFRQEQSWEFEPIKASPVQFGYRNKMEFSFGDEVKDGPLALGMHKRGSFYDIVSVKDCRIVDEDYRQILQGTLAYFTEVKAPFFHRLTHVGYLRHLLVRKASHTGEILIALVTTTQVERDLAPFRDMLLALPLQGKIAGILHIENDSVADVVRSDRTSVLYGQDYFYEELLGLKFKVSVFSFFQTNSYGAEVLYQTAREYIGNLDKEDCVVYDLYSGTGTIAQLMAPVAKKVIGVEIVEEAVEAAKKNAMLNGLDNCEFIAGDVLKVLDEIEEKPDFIILDPPRDGIHPRALQKIIKYGVDRMVYISCKPTSLARDLEVLLGNGYVVEKAVAVDQFPWTGNVETVCLLKKIKQKSLGNADRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ05</accession>
    <name>F7KJ05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05834"/>
    <dbReference type="EnsemblBacteria" id="EGN31462">
        <property type="protein sequence ID" value="EGN31462"/>
        <property type="gene ID" value="HMPREF0994_05834"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6384"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="322" mass="36217" checksum="41FBFCBFD45F92EA" modified="2011-09-21" version="1">MSVKSKGLTVPDKNAADGANRGIRKYIRHNWQLWIMLFPAMLYILIFCYIPMYGIQLAFREYSFTAGITGGKFVGMKYFRQYFESPMFWTTLKNTFVISATSILVGFPVPIILAMVINQIRSPKWKRTVQTTVYIPYFISVVVLVSMLNIMFANDSGVIANFLKSLHIVSRDTNILGKESCFVPLYVLSGVWQTMGWNSIIFIAALSSVDTQLYDACKIDGANRWQTMIHIDFPAILPTVMILLIMNMGNILNVGFDKVFLMQNSLNLGASQVISTYVYTVGIKSSQFSFGAAVGLFNTVINFVFLLVTNYISKRTTGTGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ25</accession>
    <name>F7KJ25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255630.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05854"/>
    <dbReference type="EnsemblBacteria" id="EGN31482">
        <property type="protein sequence ID" value="EGN31482"/>
        <property type="gene ID" value="HMPREF0994_05854"/>
    </dbReference>
    <dbReference type="GeneID" id="29729362"/>
    <dbReference type="eggNOG" id="ENOG50328Q2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2465086_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="88" mass="10127" checksum="A90740FE5E24A980" modified="2011-09-21" version="1">MNKRIIQFLEDIMSKKDISCASLAQLTGIAYRRLLMVFVWREALSGSELLCICRALEVKQNELMGLLDSGSQGKKITEDDRNRGYEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ77</accession>
    <name>F7KJ77_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000016">
        <property type="protein sequence ID" value="EGN31537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255685.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05909"/>
    <dbReference type="EnsemblBacteria" id="EGN31537">
        <property type="protein sequence ID" value="EGN31537"/>
        <property type="gene ID" value="HMPREF0994_05909"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117112_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039840">
        <property type="entry name" value="NAA80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538">
        <property type="entry name" value="PTHR13538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="153" mass="18072" checksum="5EE08816162592A6" modified="2011-09-21" version="1">MIVIGYLCDYPEYRENVSRWLYDEFVHREDDDLKYETFHSNFLNNNKTKLPIRLVAIADGKCVGTVTIIDNDFYGKSYSPWLGGLYVDIPYRNEGIGQRMIDFIKQIAKDLGYYEIYLNTENAGGYYKRLGWIYIETCLNEGGRMCEIYKYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJC2</accession>
    <name>F7KJC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antibiotic transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255740.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05964"/>
    <dbReference type="EnsemblBacteria" id="EGN31592">
        <property type="protein sequence ID" value="EGN31592"/>
        <property type="gene ID" value="HMPREF0994_05964"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6527"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="217" mass="23756" checksum="1082039EEC765188" modified="2011-09-21" version="1">MEPIISLKQVSKSFSGRRVLSGISLNVEKGSTVGIVGTNGSGKSVLFNLICGFLIPDRGQVCVRGQILGKGRDFPENMGVLINSPGFIGLNTGLQNLRYLAGIRGVAGDKEIRSAMQKVGLDPEDKTKVEHYSLGMKQKLGIAQAIMENQDILILDEPFNALDYKTCNDIKEIIRILQAEGRTILMTSHNYDDLETLCTHIYAIDEGKLGIYKGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJL7</accession>
    <name>F7KJL7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255827.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06051"/>
    <dbReference type="EnsemblBacteria" id="EGN31405">
        <property type="protein sequence ID" value="EGN31405"/>
        <property type="gene ID" value="HMPREF0994_06051"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6624"/>
    <dbReference type="eggNOG" id="COG2954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109545_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012042">
        <property type="entry name" value="NeuTTM/CthTTM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40114">
        <property type="entry name" value="PTHR40114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016487">
        <property type="entry name" value="CYTH_UCP016487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="148" mass="17493" checksum="79A001DF940788CC" modified="2011-09-21" version="1">MEIERKFTVRQLPEDLARYDSHLIEQGYLNTNPVVRVRREDDTYYLTYKGKGLMAREEYNLPLNEQAYNHLVSKADGNIITKRRYLIPLPPYTIELDVFMEPFAPLVIAEVEFPTEKEAEAFIPPEWFLEDVTFNPEYHNSTLSTKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJS1</accession>
    <name>F7KJS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255876.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06100"/>
    <dbReference type="EnsemblBacteria" id="EGN30726">
        <property type="protein sequence ID" value="EGN30726"/>
        <property type="gene ID" value="HMPREF0994_06100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6681"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100170_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="189" mass="22016" checksum="75DEC0CB3C8DE81D" modified="2011-09-21" version="1">MPKQRITKEMVVEAAFEIARKEGAEKVIVKNIAERLGCSVQPIYSYCSNMEGLREELVERTRAFMKDYIASRLERTNYFWSMGQAQIHFAKEEPNLFKMYFLRRRQDISSLQELYTKEGSPDMGEYLSQTLQINPEKARELHLNMIIYTMGIASILATTGSDIPEEEISDRLEKAYHAFCAQSREEHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJU9</accession>
    <name>F7KJU9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255904.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06128"/>
    <dbReference type="EnsemblBacteria" id="EGN30754">
        <property type="protein sequence ID" value="EGN30754"/>
        <property type="gene ID" value="HMPREF0994_06128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="18530" checksum="9D4EC4F41E3E8A1E" modified="2011-09-21" version="1">MTASQLLLRPLTEDDIPTIFSLTSDPEVARFMRFSTHESIQEAEDLYREYTSPGNYGYMICLKDDLTPVGVAALKKEENEEYTRSMSVYLYPCFWNRGYSTEVILHLKEAAVREGIKCLKAYVVQDNTGSCRVLEKHRFSLEEVLHFPDLPSGLCIYTQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKE1</accession>
    <name>F7KKE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002570938.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06320"/>
    <dbReference type="EnsemblBacteria" id="EGN48099">
        <property type="protein sequence ID" value="EGN48099"/>
        <property type="gene ID" value="HMPREF0994_06320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6923"/>
    <dbReference type="eggNOG" id="ENOG502Z860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129326_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="166" mass="19074" checksum="9B370C99345D5938" modified="2011-09-21" version="1">MQEEVENRTLTLVVNGTKFTGRLFKAAICKYLAHCKEKKLNKQRKREIPVKPQGKQTVKQLVGQNQGVSNIEITDPSIKEFEKIARKYGVDYAVKKDRSTSPPKYLIFFKGRDADALTAAFTEYTGKKVKKAEKTERPSVLAKLNQFKELVKNAVVDRTRRKELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKF1</accession>
    <name>F7KKF1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">HMPREF0994_06330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256092.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06330"/>
    <dbReference type="EnsemblBacteria" id="EGN48109">
        <property type="protein sequence ID" value="EGN48109"/>
        <property type="gene ID" value="HMPREF0994_06330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6933"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="144"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN48109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="29026" checksum="DA4CF9CF5601DFAD" modified="2011-09-21" version="1">MKRVMLTVAYDGTNYHGWQLQSNGISIEEVLNRCLTELLKEPVQVIGASRTDSGVHAFGNIAVFDTQARMPGDKFSYALNQRLPEDIRIRGSREVPLTFHPRKTDSIKTYEYRILNEEFPNPVKRLYSHFTYLPLDEKKMNEGAKFLIGEHDFKSFCSVNAQVESTVRTIYSCEVQREGTELVIRISGGGFLYNMVRIIAGTLMDVGNGKYPPETVADILKAKERTAAGPTAPARGLTLISYEFPELKDSPERQEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKM5</accession>
    <name>F7KKM5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256166.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06404"/>
    <dbReference type="EnsemblBacteria" id="EGN48012">
        <property type="protein sequence ID" value="EGN48012"/>
        <property type="gene ID" value="HMPREF0994_06404"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7010"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100966_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="225" mass="25234" checksum="B2642237A60F78CF" modified="2011-09-21" version="1">MKEYIYTLFEESGSLTVEEILLHILVAVILSGVIYLSYYFTHAGGVYSKKFNVSLVALTILTATVMTVIGNNIALSLGMVGALSIVRFRTAIKDSRDTAYIFWTIIVGICCGVGDYVVAVTGSAAVFAVLLILGRVRNDNRMLLIIRGARNMERRIEAVVFDYFEAKAMLRVKNTSRESIELIFEMPRKVYLLSNKKEKSIVEMLYELESIEYVNIVTQNDEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKN0</accession>
    <name>F7KKN0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">HMPREF0994_06409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256171.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06409"/>
    <dbReference type="EnsemblBacteria" id="EGN48017">
        <property type="protein sequence ID" value="EGN48017"/>
        <property type="gene ID" value="HMPREF0994_06409"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7016"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN48017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="12976" checksum="5838C350ABD0F8BC" modified="2011-09-21" version="1">MAKLSTQEIIDAIKELTVLELNDLVKACEEEFGVSAAAGVVVAAAGAGAAEAAEEKTEFDVELTEVGPNKVKVIKVVREVTGLGLKEAKDVVDGAPKVVKEAASKDDAEDIKAKLEAEGAKVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKQ2</accession>
    <name>F7KKQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06430"/>
    <dbReference type="EnsemblBacteria" id="EGN48038">
        <property type="protein sequence ID" value="EGN48038"/>
        <property type="gene ID" value="HMPREF0994_06430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356704" evidence="2">
        <location>
            <begin position="32"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="568" mass="63802" checksum="FC32BB181B742D5B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL38</accession>
    <name>F7KL38_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ORF">HMPREF0994_06571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256333.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06571"/>
    <dbReference type="EnsemblBacteria" id="EGN47290">
        <property type="protein sequence ID" value="EGN47290"/>
        <property type="gene ID" value="HMPREF0994_06571"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7193"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="212" mass="24762" checksum="18B012F44EFB1A22" modified="2011-09-21" version="1">MRLKNVPGSREVIGESRFVIHEPELQKGKWKEVFGNENPIHIEIGMGKGRFIMGMAGQHPEVNFIGIEKYSSVLLRAIQKMEEEELPNVRFIRMDAEDICNVFDKEEVSRIYLNFSDPWPKDRHAKRRLPSRQFLARYDEILKKDGTLEFKTDNRVLFDFALEELEPAGWKADTVTFDLHADEVLVRGNIMTEYEERFSAAGNPICKYVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL65</accession>
    <name>F7KL65_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06598"/>
    <dbReference type="EnsemblBacteria" id="EGN47317">
        <property type="protein sequence ID" value="EGN47317"/>
        <property type="gene ID" value="HMPREF0994_06598"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7222"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564640_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="255"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="483" mass="53575" checksum="77D6E347B3A12A15" modified="2011-09-21" version="1">MSSTKSRKEIITDKLYYPIRIAILLSVVFLFIPNLNPARISGMINKNMSLFSAGISYSSLTAEFGRAFRKGWVEESSMQLLFVSSMAMCLGIVAFCVSGCMSLGNLKFKKTGNIIGTIGCAAELAGIGGIYIAYLQISQTAKPDKIQPVFPSGLLLILIITLLILLISVIQLVLFPKLSKKSRFEMPTKYRLFLMLMPFLALVAVFAYLPLWGWRYAFFDYKVGDSISMENFVGFKWFTELFKNPATVRDIVRVLKNTLAMSGLGIATSWLPMAFAIFLSEIKNIRFRRFVQTLTTVPNFISWVLVYAIAFCIFSTDGFVSSIMVNLGIWDQGVNMLMSGDHVWIKMLGWGLWKGIGWSAIIYIAAISGIDQQLYEAATVDGAGRFQRMWHITVPGLIPTFCVLLLMSIANILSNGMDQYLVFENATNQNAIMVLDLYVYKLGIGKGAIPLSTVIGMVKSIVSVTLLFAANGVSKLIRGESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL98</accession>
    <name>F7KL98_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256381.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06627"/>
    <dbReference type="EnsemblBacteria" id="EGN46856">
        <property type="protein sequence ID" value="EGN46856"/>
        <property type="gene ID" value="HMPREF0994_06627"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085966_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="242" mass="27033" checksum="6ECDB1237514BD1F" modified="2011-09-21" version="1">MNEIIDIHSHIIPFVDDGAGSMEQSLRMLEIAASEGISAMIATPHQKADRRCVTPDGITKRLQILQEEAEKLKIPVKLYPGNEIFYRHGLAELLEAGKIRTMADSHYILIEFLPGEDYSYIRDALARTASFGYWPILAHVERYTNVIKDMDKAAELKEDTGCYFQVNASSVAGDQGLAVKNVVKKLLKMEMVDFAATDTHSDGNRAPRMKKCAAYLEKKLGTEAAGKLLMENPGYILEDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLM4</accession>
    <name>F7KLM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06753"/>
    <dbReference type="EnsemblBacteria" id="EGN46345">
        <property type="protein sequence ID" value="EGN46345"/>
        <property type="gene ID" value="HMPREF0994_06753"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7379"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005678696" evidence="5">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN46345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="445" mass="48093" checksum="0C4449C8A945A757" modified="2011-09-21" version="1">MKRKALALLLAAVMTTAMLAGCGKTQTGGSDGASQGTTPAGTEKEADASSAGSGEKAELTMWGSWSGDQVAQLEKQLEGFNNSQDKYHVTYMVQDGMEQKLLTAIASNEVPDIVLWDRFNTGVYAPKGALVSLDDYIAKDNVDMTQFYAPAVDEMTSAGVVYGIPLTVDSRVLFYNKDLLDEAGVDPASITDWDSLRDAAIKLTKWDGDKLVQSGFSLKDVGLFNNWIGQAGGKMIDDSTNPPTAAFNTEAGLTVLKYWDQLLNQDKVYQLGFEDGFGGDGFKAGKVAITFNGPWTLESYKEAGLNFGVIGQPQGYNGEKSAMMGGFGLVIPNGAKNPDASWEFIKWWTMQPENGVEFCKISGNLPANKEAAKDPYFMDDDILRVFSETMDYAGIRSKVFGYSDLEGLALIPQLQKYVAGEITAEEALSNAEKQGNDILAEAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>S2LA16</accession>
    <name>S2LA16_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07255"/>
    <dbReference type="EnsemblBacteria" id="EPC05106">
        <property type="protein sequence ID" value="EPC05106"/>
        <property type="gene ID" value="HMPREF0994_07255"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097468_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="195" mass="22356" checksum="D112A3BD4D4CD3FC" modified="2013-09-18" version="1">MKTMENRAVRIVRLTGEDREKLLECAKLLFVCFEHAWNTMEEAEEDMLRILEAGPVLAAVEEELVVGFIGTRPTYEPYGWELHPLAVEERSRKKGIGSLLIKEIEKEAVNRGAIVMYLGTDDEDGATSLSEGDLFIDTFQKIKNIKNKKNHPYEFYEKNGYQIVGVLPDVNGYGRPDIYMAKRLCEKVQLRNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>S2LA72</accession>
    <name>S2LA72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360160.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07211"/>
    <dbReference type="EnsemblBacteria" id="EPC05156">
        <property type="protein sequence ID" value="EPC05156"/>
        <property type="gene ID" value="HMPREF0994_07211"/>
    </dbReference>
    <dbReference type="GeneID" id="29728060"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074803_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="35523" checksum="B0623A40644A4331" modified="2013-09-18" version="1">MKFCVFTDLHYDVIPDGDRRIYELIQECKRKKAEFAVELGDLCNPTKENHRILDLFIDAGISCYHSIWNHNTDFSSSEKVLSFFGLKEGYYSIIRDNIKFIFLDPNHIRTESDCTPECNANLTASSDKSPYIPKEQIEWLKSEIADENYFYIICSHQSLCNDFMVGNHSRGIVNREAVRKILEERNSLSRKILFCINGNDHGDDVKLINGIYYYSLNSASYIWHGVKEMYNYSKEVHDKYPYLKDMILYEEPLHVIITIDENTNVEIEGMKGHYQNVTPEDIGIADTWNGVSIRPHTSSLKISASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJY0</accession>
    <name>S2LJY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07097"/>
    <dbReference type="EnsemblBacteria" id="EPC05248">
        <property type="protein sequence ID" value="EPC05248"/>
        <property type="gene ID" value="HMPREF0994_07097"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067283_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="34483" checksum="09ABA25B5313BF8B" modified="2013-09-18" version="1">MEKEKQKEKQTEVTEIHHEDLALKTAAQYFGKELLPLLGIPGEVKYIAPTESVKLETRQMYQDFNYVSEEGSWIHLEFESDAVTDDDLRRFREYEAATSRTFHVAVITYVICSSKVKRLKAALAEGINVYHVKIIRLKDDDADQLLSGLEEKQKQGIPLEKAELVSLLLTPLMSGSMEIGDRIIKSFGIMKKSGDAVTEMELEKMYAVLYTLADKFLSEKELNRVKEMLAMTKLGTMLFNDGKAEGKAELVAIIRKKREKGHNISDIAEDLELSMVYVKKVAELMDEDPARTDLQVAEILISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>S2LK60</accession>
    <name>S2LK60_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359775.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06996"/>
    <dbReference type="EnsemblBacteria" id="EPC05328">
        <property type="protein sequence ID" value="EPC05328"/>
        <property type="gene ID" value="HMPREF0994_06996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036805_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EPC05328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="398" mass="45748" checksum="AC16149920DA5754" modified="2013-09-18" version="1">MTSGFNYQEELSKCSTMEDITGPNGLVQRMVKDAIEQILQSEITDYITDEKSKGNTPQRNGTSPKKVKTSYGSIDIDVPRVREGEFEPEVIKKRAVIEEGLEAQIISMYAKGMTVRDIVSHVQALYGIELSPASVSNITDKIMEEAREWYSRTLDGFYPVVFLDAVHYKVREEGRIVTKASYVALGINAEGRKDILGIWIGENEGAKFWLKVCNELKNRGVKDILIACIDGLPGFPDAIKTVFPETRIQLCIIHQIRNTMKYIAYKDSKAFMKDLKRVYGAESEEIAFRNLEAMKDSWKKYRAVVENWQMKWENLSTYFSYGAQIRRLIYTTNTLEGFNRQLRKVTKNKAVFPNDEALRKTLYLTTRDITEKWSMPYRDWGETYGQFIIEFGDRASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2C4</accession>
    <name>F7K2C4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249952.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00003"/>
    <dbReference type="EnsemblBacteria" id="EGN48236">
        <property type="protein sequence ID" value="EGN48236"/>
        <property type="gene ID" value="HMPREF0994_00003"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_31_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="74" mass="8459" checksum="7B4F628AF0016E23" modified="2011-09-21" version="1">MHISYKPLWHTLVERNMRKEDLRLAAGLTTNMIANMGKGKNISMETLVRICEALNCGILDVIELEQDKEDEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2D5</accession>
    <name>F7K2D5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249963.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00014"/>
    <dbReference type="EnsemblBacteria" id="EGN48247">
        <property type="protein sequence ID" value="EGN48247"/>
        <property type="gene ID" value="HMPREF0994_00014"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.16"/>
    <dbReference type="eggNOG" id="ENOG5032RVM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191489_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="65" mass="7308" checksum="BBFF788C92A4034B" modified="2011-09-21" version="1">MAKNKTEIHVTTVFDGELDATDVFVSLIAQKYSQRNDKEYLAKKQDLGYNKDKVQSDRVPSGLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2D6</accession>
    <name>F7K2D6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249964.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00015"/>
    <dbReference type="EnsemblBacteria" id="EGN48248">
        <property type="protein sequence ID" value="EGN48248"/>
        <property type="gene ID" value="HMPREF0994_00015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.17"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="175"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="420"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN48248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="554" mass="63944" checksum="1340A52CB776464B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2F3</accession>
    <name>F7K2F3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_00032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249981.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00032"/>
    <dbReference type="EnsemblBacteria" id="EGN48265">
        <property type="protein sequence ID" value="EGN48265"/>
        <property type="gene ID" value="HMPREF0994_00032"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.35"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN48265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="702" mass="77847" checksum="055D622DEF5B2567" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Y3</accession>
    <name>F7K2Y3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250161.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00212"/>
    <dbReference type="EnsemblBacteria" id="EGN39245">
        <property type="protein sequence ID" value="EGN39245"/>
        <property type="gene ID" value="HMPREF0994_00212"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.225"/>
    <dbReference type="eggNOG" id="COG2964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080179_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013559">
        <property type="entry name" value="YheO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08348">
        <property type="entry name" value="PAS_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_6" evidence="1">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_22" evidence="2">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="224" mass="25002" checksum="4D180E96A646EA01" modified="2011-09-21" version="1">MDIPYIELTATDRQILNSYALMLDGLGAYLGEGYELVLHSLESLDHSVIKIINGHYTGRKEGSPITDLALKMLGELERDPARTVSPYFNKNKSGALLRSCTIPITGEHGRIIGLLCMNFHMESPLSTLLQNFIPPQENISASQPPAETFSDNIDDLIFSALTETREAVYSDSAISSANKNKEIVLQLYQRGIFNLKDAVIKVAEQLNISKNTVYMHIRNFKNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K324</accession>
    <name>F7K324_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250202.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00253"/>
    <dbReference type="EnsemblBacteria" id="EGN37892">
        <property type="protein sequence ID" value="EGN37892"/>
        <property type="gene ID" value="HMPREF0994_00253"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033NG4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155798_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021560">
        <property type="entry name" value="DUF3021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11457">
        <property type="entry name" value="DUF3021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="138" mass="15453" checksum="9524E0D76C382F5A" modified="2011-09-21" version="1">MKKMAVNILCSTGITLIVLAALGTMYGAHYLFIKSVFQSFFANIIIHAGLRLTHRFESGYAALEYMLDIGYTIAVVILCGAAFDWYTSTPVWLLIIMSVVIYLAAVSLSIFRMKKDIEEINELVKRRNHLIDSGRISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K365</accession>
    <name>F7K365_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monovalent cation/proton antiporter, MnhG/PhaG subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250243.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00294"/>
    <dbReference type="EnsemblBacteria" id="EGN33435">
        <property type="protein sequence ID" value="EGN33435"/>
        <property type="gene ID" value="HMPREF0994_00294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="100" mass="10592" checksum="ED10E75CCD1DCF02" modified="2011-09-21" version="1">MKVIGEILMGAGLFIMLCGIAGLLKNPGFYRRLLLSSLIDTVGLLVLLAGVAVRQGLGSFSFKVILLMGIVILTAPLSAHKLGRAAYLSGHREGGMEHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3A9</accession>
    <name>F7K3A9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250291.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00342"/>
    <dbReference type="EnsemblBacteria" id="EGN33483">
        <property type="protein sequence ID" value="EGN33483"/>
        <property type="gene ID" value="HMPREF0994_00342"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.369"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="235" mass="25531" checksum="78F1179056B1D017" modified="2011-09-21" version="1">MITITNISKAYAATPVLEGCSFQVPDGAIYALAGRNGAGKSTLLKLAAGFLCPDIGEIRVQGKQTWENRESIQKDIGTLIDVPVFYEHLSAVENLKLQQAYQKTDTDIGGILEKVGLSGISEKPVSAFSTGMRQRLAIARALLHNPRVLLLDEPLNGLDPLGAEELRSLFVSLAEEGKTLLISSHILSDISAMADTVGILSGHRICREFDMEQYRGSRKEAFEQEVLAAMKGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3D3</accession>
    <name>F7K3D3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250315.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00366"/>
    <dbReference type="EnsemblBacteria" id="EGN33507">
        <property type="protein sequence ID" value="EGN33507"/>
        <property type="gene ID" value="HMPREF0994_00366"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.396"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="191"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="34754" checksum="048012BCBA10DA63" modified="2011-09-21" version="1">MKKEEHYLERASYTWSEDSVRLFATPSMTARSLYFYMQEAGYFKTVWPYFTERASLNSFLVLYTLSGEGRLSYEGQEYEVTEGTCFFIHCMKHHEYHTVKGKNWEFLWLHFNGGNALGYYEEFVKNGFRILDIRQKERTEGLFREILSINRKRELTTEVRTGGLIGTLLTELIARNTTEGRQAILIPSGIRAAEKYLEQHFREKVMLQELADMLHMDKFCLIKEFSRYVGISPHEYQIELRLSYAKELLKYSDLSVNEIAYACGVNQTSHFIGLFKDREHITPAKFRKEWRTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3E5</accession>
    <name>F7K3E5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00378"/>
    <dbReference type="EnsemblBacteria" id="EGN33519">
        <property type="protein sequence ID" value="EGN33519"/>
        <property type="gene ID" value="HMPREF0994_00378"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.409"/>
    <dbReference type="eggNOG" id="ENOG5032Y15">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128087_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="162" mass="18427" checksum="5C0DDE67E1C0073F" modified="2011-09-21" version="1">MNIVHIIKTFMEDVPLKINKKHLLLLAGIIWAVAGFNILRIGILSYRGNVTLLNLFLSCVIFAAFWFLVFDKLVRKHTFRILNYQEEKQFFLKFFDIKSFCIMAFMMTFGIGLRVSGLCPDLFIAVFYTGLGTALFLAGASFASNYFQALRTCGEDDPDPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3J0</accession>
    <name>F7K3J0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250368.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00419"/>
    <dbReference type="EnsemblBacteria" id="EGN31934">
        <property type="protein sequence ID" value="EGN31934"/>
        <property type="gene ID" value="HMPREF0994_00419"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.459"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="33171" checksum="5AA8123B22A2B3A6" modified="2011-09-21" version="1">MHKKEIRFQLLCHIIMGIAAVVTILPLILLFISSITANKDITLYGYSFVPKHLSMEAYSYIWNERMQIFRAYFITVFVTAVGTGVGLSISVLYAYALSKPYFPGKKFFSFFILFTMLFNGGLVPSYIMYTRYLHMKNTILALIIPGLLMNAFNVILIRSYFQNNVPLSLVEAAQIDGASEFQVVLKVVLPMSKPIIATIGLFIGVAYWNDWQNGLYYVTDEKIYSIQQILNNMLKNIEYLSKNATSVAKSTSLAGTLPAATVRMAIAVIGLLPILVIYPFVQKYFVKGISLGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3N1</accession>
    <name>F7K3N1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250409.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00460"/>
    <dbReference type="EnsemblBacteria" id="EGN48178">
        <property type="protein sequence ID" value="EGN48178"/>
        <property type="gene ID" value="HMPREF0994_00460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.505"/>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070025_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="13628" checksum="7EAE511EC4698197" modified="2011-09-21" version="1">MNKTRFETGMENLKKIDGDGGDAVIRSLENISPDLGTYIVEFAFGDIYARPGLTLQEREIITLASLLTAGGCEPQLEVHISAALHVGLSKEKIIETFLQCIPYTGFPKVLNAIFTADKLFQKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Y2</accession>
    <name>F7K3Y2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flg_hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00561"/>
    <dbReference type="EnsemblBacteria" id="EGN44749">
        <property type="protein sequence ID" value="EGN44749"/>
        <property type="gene ID" value="HMPREF0994_00561"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605186_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="327"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="452" mass="48514" checksum="B3C89D7BB83DA9F0" modified="2011-09-21" version="1">MTVQTVQNAGITGTGKDNRQSAAARDTFMEMLNTHLNQASDRKNANAGPGKAASQPGQKSGEPVKKEENAAGKASRDTQDKAGDALKETAGNAEDKPADKVEKPGKEQTEAAAGILMEEQMQQNGWEMILPGEELSGNTGSREEEMSLSGIVQTANAAEAFPGGSEQNPAAIINTAAGETQYARGKKTDRQTAGTAEDISVLKDSGLENAAQAGSTGVKAAGNGQEAFGDSASSYGDMLKEQSELLKAMAGIGKEEKDTEISYVLQDKETDTEALQKKVDEKAYLPLDRMIAVRTADRPEMTAVPNTQTEAVPVMQQVKTGLEEGMAKGMNHFTIRLKPEGLGEIVVRMVTEGGRISMRIGVSNEDTQRLINSELLQLKEALQPLNAQVQEVYHSGFGGMDFSGYQQDMYRQQHQMTGGILRHFGATAAGEEEDIPEIPVYNRMEGSLYAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K412</accession>
    <name>F7K412_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FliA/WhiG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00599"/>
    <dbReference type="EnsemblBacteria" id="EGN44787">
        <property type="protein sequence ID" value="EGN44787"/>
        <property type="gene ID" value="HMPREF0994_00599"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.651"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN44787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="263" mass="30790" checksum="D4D34D8ABAFF0409" modified="2011-09-21" version="1">MVLEVKPKKTDYGKMTDEELWEEYEKKGGLELKQELALRYIYIVRNVAIQMRDVYMSFAQLDDIINEGVIVVMSAIDKYDLHLNVKFETFVSKRIRGMIIDMARKQDWVPRTVRKNAREIDEATMHLYGKTGRMPTAQETAEYLNMPLDKYEKVLSKANLFYILSLDMLMEEKAENRQTVQIPSHNYREQPEECYLGDEFKGILADGIRSLKENEQTVISLYYKEELSARDIAKVLGVSEPRISQIHSSAIRKLKTYIENRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K443</accession>
    <name>F7K443_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00634"/>
    <dbReference type="EnsemblBacteria" id="EGN44822">
        <property type="protein sequence ID" value="EGN44822"/>
        <property type="gene ID" value="HMPREF0994_00634"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.687"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_16_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="307"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN44822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="586" mass="63308" checksum="BDE6976A0DB7E245" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4N3</accession>
    <name>F7K4N3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250769.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00820"/>
    <dbReference type="EnsemblBacteria" id="EGN43529">
        <property type="protein sequence ID" value="EGN43529"/>
        <property type="gene ID" value="HMPREF0994_00820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.895"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061789_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="47"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="265" mass="30286" checksum="B27A75FF28BB2318" modified="2011-09-21" version="1">MNKNDYLNSYYSTYQEDARLTATKHGLVEYLTTMKYIHRFLNKGMRILEIGAGTGRYSLALAKEGFRVDAVELLTHNLDILRSKMAELPDGGSIRAYQGDALDLSRFEDGTFDGTLVLGPMYHLYTEEDQRKALQEACRVTKKNGYLFVAYCMSDPTMVGELFPLGEVKKYLEQKKLTEDFHILSESEDLFHLARTEDIEKLDGTIDAERLMLVATDGPTGYMRPVIDSMDDDTFALYMRYHFAVCERSDLIGASHHTLDILKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4P4</accession>
    <name>F7K4P4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250758.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00809"/>
    <dbReference type="EnsemblBacteria" id="EGN43518">
        <property type="protein sequence ID" value="EGN43518"/>
        <property type="gene ID" value="HMPREF0994_00809"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.882"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="34075" checksum="5C60D8992540BCF6" modified="2011-09-21" version="1">MVQNLEYYKVFYHVARCGSLTLAAQELSISQPAVSQSVKLLETSVGVKLFVRSAKGVKLTKEGELLYSYVAGGYEQIEMGEKKLKQMMDLELGEIRIGASDMTLRFYLLPYLERFHELCPGIKVMVTNAPTPETLVFLKSGKIDFGVVSTPFSGEGVHSETVREIEDIFVAGRQFFQYKNKTLDLHDLENLPLITLEKNTSTRSCMDSFLAENGVRINPEFELATSDMIVQFALRSLGIGNVVRDFAAEYLESGRLFELRFNKMIPRRHFCVVTGKGNLLSAAARRLLELIQTEEYRKEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4X4</accession>
    <name>F7K4X4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00903"/>
    <dbReference type="EnsemblBacteria" id="EGN43212">
        <property type="protein sequence ID" value="EGN43212"/>
        <property type="gene ID" value="HMPREF0994_00903"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.988"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="38947" checksum="813A33294E1FB898" modified="2011-09-21" version="1">MTMEEMARIIGISRITLSKVMNNKDGVSEETRQRVKEYIERYNFEPNSQARSLVGKKEQIIGFFTTYSEEAGGNTHVTSHFATELVNLVVNAAQKRGYKTLVDITPKEDDFSEVEKYLNSGLIRGAILFGYASGSPNLEYLSRKGVPLVLINQEVTLDLPNISLVNMDDETWGYQAIECLVKLNHRRLLYLTCSRRRLPVKRRAHGVKRALEAYKDQILSFQECNGEFNEDLSYEIVKKIYTQEREKPTGIFAANDQMAIGAINALKDLGIRVPEEVSVIGFDDISISKYLTPALTTIHCDFKEIADRSVEALIDSIEGKVEKSHQELPLEFVKRESLAFHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4X6</accession>
    <name>F7K4X6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250854.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00905"/>
    <dbReference type="EnsemblBacteria" id="EGN43214">
        <property type="protein sequence ID" value="EGN43214"/>
        <property type="gene ID" value="HMPREF0994_00905"/>
    </dbReference>
    <dbReference type="GeneID" id="29723956"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363714" evidence="2">
        <location>
            <begin position="34"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="531" mass="59136" checksum="890A2899F2F2D13D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K508</accession>
    <name>F7K508_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250893.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00944"/>
    <dbReference type="EnsemblBacteria" id="EGN43253">
        <property type="protein sequence ID" value="EGN43253"/>
        <property type="gene ID" value="HMPREF0994_00944"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1032"/>
    <dbReference type="eggNOG" id="COG3238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068878_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="143" mass="15572" checksum="1BAA2ADFC97166F3" modified="2011-09-21" version="1">MIGLIIALISGALMSIQGVFNTEVTKSSSIWVANCFVQFTALLVCLIAWAFSDRSSLLGVFQVQPKYMLLGGAIGAFITYTVIKSMDMLGPARAVMLIVVAQLLVAYLIELFGMFGVEKTGWEWRKAIGMAVAIAGIVIFKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K535</accession>
    <name>F7K535_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250922.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00973"/>
    <dbReference type="EnsemblBacteria" id="EGN43282">
        <property type="protein sequence ID" value="EGN43282"/>
        <property type="gene ID" value="HMPREF0994_00973"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1063"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="392"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="513" mass="60417" checksum="3D1308F726373358" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5B8</accession>
    <name>F7K5B8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250996.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01047"/>
    <dbReference type="EnsemblBacteria" id="EGN43020">
        <property type="protein sequence ID" value="EGN43020"/>
        <property type="gene ID" value="HMPREF0994_01047"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1145"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="468" mass="51747" checksum="C911EF605028CDB5" modified="2011-09-21" version="1">MEEKTYVDDIDRSIYDIKNDEKDVYRIQEGLTPEIVTEISREKKDPSWMEIFRLQSLQIYNRMKAPDWGPSLEGLDMEHIVTYVRPNTHMSGKWSDVPEEIKNTFELLGIPQAEQKSLAGVGAQYDSELVYHHVREEVAAQGVVYTDMESALKGEYAPMVQKHFMKLVRPDDHKFAALHGAVWSGGSFVYVPPGVSVTIPLQSYFRLNAPGAGQFEHTLIIVDEGADLHFIEGCSAPKYNVANLHAGCVELYVRKNAKLRYSTIENWSKNMYNLNTKRAVVEEGGVIEWVSGSFGSHVSCLYPMSILKGKGARAEFTGITFAGKGQNLDTGAKMVHQGPNTSSFVNTKSISKDGGVSTFRSSVVVGKDAAGSKAAVSCQSLMLDDYSRSDTIPAMDIRTPDADVGHEAQIGRISEEAVFYLMSRGIGEEDARAMIVSGFADNVSKELPLEYAVEMNNLIQLEMKGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5C8</accession>
    <name>F7K5C8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01057"/>
    <dbReference type="EnsemblBacteria" id="EGN43030">
        <property type="protein sequence ID" value="EGN43030"/>
        <property type="gene ID" value="HMPREF0994_01057"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1157"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016116_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="35832" checksum="7F46FABD79C949B2" modified="2011-09-21" version="1">METKLINGETWYDTDGNILHAHGGHMLKWEGNWYWYGENRTDNRYVSVYKSGDLINWTFCRHALTADSPTAEHRVRTERKLRSESGCKINVERPKVLYNKKTNQFVMWMHIENGVDYLDAACGIAVCDRPDGEFTYLGCFNPFGYMSRDCTLFQDKDGTAYFISASRDNADLHMYRLTEDYLNVDCLVHKLWQGEYREAPAVMEREGKYYMFSSYCTGWAPNQCRYAMADSMEGRWSSLTDIGDETTFRTQPAFILPLEKEGKKEYYYVADRWNGEDYHDSRYVILPLGFTPEGLPVMEYTECFGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5H0</accession>
    <name>F7K5H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01099"/>
    <dbReference type="EnsemblBacteria" id="EGN42861">
        <property type="protein sequence ID" value="EGN42861"/>
        <property type="gene ID" value="HMPREF0994_01099"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034536_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="548" mass="62618" checksum="629BFFDA5C41B18C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5P8</accession>
    <name>F7K5P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251126.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01177"/>
    <dbReference type="EnsemblBacteria" id="EGN42578">
        <property type="protein sequence ID" value="EGN42578"/>
        <property type="gene ID" value="HMPREF0994_01177"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1288"/>
    <dbReference type="eggNOG" id="COG3949">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039711_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038728">
        <property type="entry name" value="YkvI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37814">
        <property type="entry name" value="PTHR37814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="381" mass="41922" checksum="0E4A82ABE0493D03" modified="2011-09-21" version="1">MKSLKKFYEGGYAKYILPGVLLQSVLIGGGYATGREIYSYGAKFGAMGWISGITIGIGFALFAFLTFEICRIYKVYDYKNYIKQVIGPLWPVMDVLTVLIAIMLIAVMAAATGSIFEQVGLPNFLGAVVIVLLCGLLNFKGSKVIEKFESVGTILLYGGYILFTIIVLISKGSNIPQVFAAADTSAYDGKVTLGLCIWTGILYVAYNINSIPMGMFSLTRQTKRKETFFSGLIAGLLMVIPWFLSYFAMMCFYGDTSIVGADVATPWMEMIKAVNGGPVLLALFSIVMGWTLVETATGCIHMIIDRFDIALEERGNARLTDKNRGLITVITLLAALLLSRIGVVTLIEKGYSYLSYGFILFYLLPTLFIGGYKIIRYKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5Q1</accession>
    <name>F7K5Q1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251129.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01180"/>
    <dbReference type="EnsemblBacteria" id="EGN42581">
        <property type="protein sequence ID" value="EGN42581"/>
        <property type="gene ID" value="HMPREF0994_01180"/>
    </dbReference>
    <dbReference type="GeneID" id="29723453"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1292"/>
    <dbReference type="eggNOG" id="COG5423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097790_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019271">
        <property type="entry name" value="DUF2284_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10050">
        <property type="entry name" value="DUF2284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="178" mass="20168" checksum="2BC07126E5401A9E" modified="2011-09-21" version="1">MEGIEQIFEMCKEAGVHEQAVLPVEKLRFSDEVRHLCEVNYCGCYGKTWACPPGVGSVEECRERCMAYSRVYVFNTWHPLENSLDLEGMQEGKEAHEKVCARVRKIFEEAFKQVLVLTSEGCGNCRTCTYPDAPCRFPERMCPSVESHGIFVNEEAAEAGLHYINGANTVTYFGNVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5T5</accession>
    <name>F7K5T5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251163.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01214"/>
    <dbReference type="EnsemblBacteria" id="EGN42540">
        <property type="protein sequence ID" value="EGN42540"/>
        <property type="gene ID" value="HMPREF0994_01214"/>
    </dbReference>
    <dbReference type="GeneID" id="29725535"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1327"/>
    <dbReference type="eggNOG" id="COG2365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="270" mass="30704" checksum="CB47CFAFC70E8A10" modified="2011-09-21" version="1">MKEITRIPLEGLHNTRDLGGFETADGRKIRPRRLIRSGQLSGMTEKDKQVLTEDYGLRTDVDFRTGQERTEAPDPRLPGVAYVENPILSDQAIGITREKDSEEDMMKLLVQQMSTSEKAAEEYMAGLYRNLVMDPFSRQQYRKFFGILLDQKEGAVLWHCSAGKDRVGVGTALLLSALGVPRETILADYMMVNTFTAEVVESRLEELNEGLQNPQLIDCLRELMQVQESYLISVFQAIEDGYGTMDSFLEKEMGLCAEKREQLREMYLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K605</accession>
    <name>F7K605_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42316.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01284"/>
    <dbReference type="EnsemblBacteria" id="EGN42316">
        <property type="protein sequence ID" value="EGN42316"/>
        <property type="gene ID" value="HMPREF0994_01284"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42316.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="322" mass="36628" checksum="EBEC52BE16DDB1BD" modified="2013-09-18" version="2">MKTTVIIPNYNGIDYLENCLRSLENSFADKAPAFEVCIVDNGSVDGSPEMAEQLFPWTHIIRFPENRGFCAAINEGITRARTPYVFLLNNDTTIDPACIRRLERRMDNDPRLFSAAAKMLSMKNPDIMDGAGDRYNALGWAFAIGKGRPSTDYNTPMPIFSASAGAALYRKEYLQKTGLLDELHFAYLEDVDLGYRARILGYRNAYEPTAKVYHAGSATTGSRYNPFKITHSSRNNIYLIYKNMPLFQLILNLPFLIAGFFIKTLFFCAKGYAGVYLKGLGEGIRLCTTPEARQRKFRFKPANFGHYITIQLELWLNIFRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K638</accession>
    <name>F7K638_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251266.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01317"/>
    <dbReference type="EnsemblBacteria" id="EGN42179">
        <property type="protein sequence ID" value="EGN42179"/>
        <property type="gene ID" value="HMPREF0994_01317"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1439"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="336" mass="37868" checksum="86F2164401302CC2" modified="2011-09-21" version="1">MNEQQKRENTLYLVVPCYNEEEVLLHTAEVMLVKLKRLIKEGKISSKSKVMFVNDGSRDNTWNLINALCKQSVFFSGLSFSRNYGHQSAILAGMMAARAHADMVVTIDADLQQDIEALDDFISCYMAGCEIVYGVRCDRDSDGFFKKLSANVFYGLMHLLGCKVMSNHADYRLLSKRALDALAEYKEVNLFLRGLIPTMGFQSDVVYFEVKKREAGQSKYTLKKMITLATDGITSMSTRPIQIITILGFLVSLFSFCMIIYCIIDWFSGRNVPGYTTSLVVSLLTGGLTIFSLGIVGEYVGKIYLETKARPRYIVESFIWKEAGDEAEDMKEENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6E9</accession>
    <name>F7K6E9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251403.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41928">
        <property type="protein sequence ID" value="EGN41928"/>
        <property type="gene ID" value="HMPREF0994_01454"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1584"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="462" mass="50277" checksum="5861D5B766AE76F8" modified="2011-09-21" version="1">MEQKSNAFLEKEKVGTLMKKYAVPCIISLLVAALYNIVDQIFIANASYLGSYGNAANTVVFPLTVVALAVAVMIGDGCCAFVSISLGADEKENAHRSIGSAVVLCILASVLLTAVYFLFRDPILTMFGGRVNEETFRYSKEYFIYISMGIPFYMFGQAMNPIIRSDGSPKFAMISTLAGAVINIILDPLFIFVFRWGMMGAAVATVIGQVVTALLAVWYLFHMKAVKLEKVSFLVSGRLTKKFLPLGICSFLSQISLVAAMAAINNMIRKYGALDPVFGQTEYAQIPMAVVGIVMKFFQIVISISVGMAAGCIPIVGYNIGAGRKDRARALFTRLLTAEAAVGAAALLIVELFPRQLIAVFGAANESAYYTDFAVKSFRIYLCMMIFACVNKATFIYLQSLGKALLSTVLSMVREVVFGVGFALLLPLFFGLDGVLYSMPVSDILTFLVSAAVIRYTYRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6T7</accession>
    <name>F7K6T7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251535.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01604"/>
    <dbReference type="EnsemblBacteria" id="EGN42078">
        <property type="protein sequence ID" value="EGN42078"/>
        <property type="gene ID" value="HMPREF0994_01604"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1753"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081534_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="212" mass="23772" checksum="A736D6193F72120D" modified="2011-09-21" version="1">MGIFKQFFNNTRKPDGWMGKLMVNGMNQGHAAVSDWGLSYFPDIPVAAHSMVADFGCGGGRNTAALLKRFPAATVTALDYSKVACDKTKQFNRHEVQIGRCNVVQGDVSRLPFEAATFDVITAFETVYFWPGPVESFQEVWRVLKPGGTFMIVNESDGRNTKDEKWAGIIDGMRIFTQERLTQYLKDAGFSQIAAHVNRKQHWICLLAEKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K755</accession>
    <name>F7K755_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ORF">HMPREF0994_01684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01684"/>
    <dbReference type="EnsemblBacteria" id="EGN41722">
        <property type="protein sequence ID" value="EGN41722"/>
        <property type="gene ID" value="HMPREF0994_01684"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1838"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="10"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="285"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN41722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="366" mass="40254" checksum="D5D72A4B82F988CE" modified="2011-09-21" version="1">MPMEECRTSLYDTHVKYGGKMVPFAGFLLPVQYEKTGVIKEHMAVRTGCGLFDVSHMGEILCEGEGVLANLNDLLTNDFTGMYDGQARYSPMCNGEGGVVDDLIVYKIRENRYFIVVNAANKEKDFEWMLAHQREGAIFTDISPKVGQIALQGPLAQRILSRVSAEESIPGRYYSCVAEGKAAGIECLISRTGYTGEDGFELYMDSEKAPALWEALMEAGKEDGLTPCGLGARDTLRLEAAMPLYGHEMDDEITPLETGLKFAVKMKKDHFIGKEALEKAGNPTRKRVGLKVTGRGIIREGADIYIGDERIGKSTSGTHAPYLGYPVAMALVQAEKADVGSRVEADVRGRRVEAEVVELPFYKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K785</accession>
    <name>F7K785_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251627.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01714"/>
    <dbReference type="EnsemblBacteria" id="EGN41696">
        <property type="protein sequence ID" value="EGN41696"/>
        <property type="gene ID" value="HMPREF0994_01714"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1873"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="292" mass="32536" checksum="F6456032B3AAC04E" modified="2011-09-21" version="1">MPISKGEKIFNIINSIFLTAVALFCLAPMIYMLAVSLSDNAQVVAGNVTFWPKKFTTATYEYLLSYKAFWKSMGISITRTALSLVLTLCLTVLSAYPLSKSPGKFYGRSIFAWYFFIPMLINGGLIPTYMIISRLGLIGSLWALILPSAVTVFYVMLLLNFFRGLPEELEEAALLDGAGQWTILVRIFLPLATPALATIAVYCSLAQWNEWFNGIIYMKTPSQYPLMSYLQATVLNVDMESLSAEEQMKMASIGTDTYQAAQLFIAALPMLCIYPFMQKYFTKGLVMGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7N5</accession>
    <name>F7K7N5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251842.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01929"/>
    <dbReference type="EnsemblBacteria" id="EGN41334">
        <property type="protein sequence ID" value="EGN41334"/>
        <property type="gene ID" value="HMPREF0994_01929"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2118"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_12_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="35682" checksum="E4C3CE6D7F944D6B" modified="2011-09-21" version="1">MESKIVDNYESVTLHQSLLISKLFTVHYFEYMNDFSFPGEAHNFWEFLCVDKGEVDVVAGSRSLSLKKDEIIFHKPNEFHTVRSNGRVAPNVVVISFECTSPSMDFFKDRILTIGEAERSLIAQIIMEARQLFSCPLDDPYLKKMELAENPPFGCSQMIQLHLEQLLIQLIRRHTASRQEKKQPSTLKQKSDGDLYERIMNYLDQNLYTQITIEQICKDNLVGRSQLQKLFRERNGCGIIDYFSHMKIDAAKQLIRNQSLNFTQIADTMGYTSVHYFSRQFKKVTGMTPSEYSSSIKKLSEEPQFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Q7</accession>
    <name>F7K7Q7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01952"/>
    <dbReference type="EnsemblBacteria" id="EGN41357">
        <property type="protein sequence ID" value="EGN41357"/>
        <property type="gene ID" value="HMPREF0994_01952"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2146"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082998_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="34613" checksum="070367F7B67DA1C8" modified="2011-09-21" version="1">MGSGKEVYKGIRTIKGDFQLHGPKQREDAQMGANMRVGILVNLHADMDLKEKFGELKEMGVESCQLVCWDRSLLNEETAAVVREAVREKGIEITAFWCGWEGPKVWNFYEGQETLGLVPQAFRFRRLEMLLEGSDFARLLGVDNLVTHVGYMPENPYDPNYHSVIACLKELALRCKNNGQNFLFETGQETPVTLKRAIQDIGTGNVGINLDPANLLMYGKGNPVDSLDVFGEYVMGIHGKDGCYPTNGYELGEEKPLGQGKVNYPAFIRKLKEIGYDGDITIEREISGEEQKRDILAAKQMLEELIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7U6</accession>
    <name>F7K7U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251905.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01992"/>
    <dbReference type="EnsemblBacteria" id="EGN41397">
        <property type="protein sequence ID" value="EGN41397"/>
        <property type="gene ID" value="HMPREF0994_01992"/>
    </dbReference>
    <dbReference type="GeneID" id="29727644"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2188"/>
    <dbReference type="eggNOG" id="ENOG502Z8M5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017193_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="843" mass="94645" checksum="096F8DAF4965F0EB" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Q2</accession>
    <name>F7K8Q2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252147.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02246"/>
    <dbReference type="EnsemblBacteria" id="EGN41153">
        <property type="protein sequence ID" value="EGN41153"/>
        <property type="gene ID" value="HMPREF0994_02246"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2452"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="198"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="415" mass="46616" checksum="62DE12B1F1F5B2A6" modified="2011-09-21" version="1">MIEALRRRFLMIAMLSLTGTLCVIGASINLGNLYRITRLADTAIELLYQNDGTFPLSDGERPDVAGGFQITEETPFETRYCIVHLTKKREVREVEMEHIAALDREKVVDLVSEIIRDGKKSGFNGYYRYQVYEKGEESTIVVLNCFLQLQSVYNVLQVTLLVIVCCVTLVFFLLLLLSGRVIRPFAENIERQKRFLTDVSHELKTPLGIISANTGVLELTKGKDEWTESIRNQVKRLDSLIKDLIELSKSEEYVKESEFTEFSVSQIAETNADSFRTLAQMQGKQLNAEIEPGVCMRGQEDSIIRLMTILLDNGVKYCDPSGTVELRLRQKGRQVVLQVANPCRDMDTAQVPHLFDRFYRADSSRSRQSGGYGIGLSIARAVTEGHKGRIGAAYEAGNLVFTVVLPGIAGKNIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7K945</accession>
    <name>F7K945_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02383"/>
    <dbReference type="EnsemblBacteria" id="EGN40782">
        <property type="protein sequence ID" value="EGN40782"/>
        <property type="gene ID" value="HMPREF0994_02383"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3169375_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="47" mass="5305" checksum="5A81FEE178A0C049" modified="2011-09-21" version="1">MGNEREQFMENAGNVLFEVEESGKEMMNSNQIPANTESTPFLSIFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9J0</accession>
    <name>F7K9J0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252454.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02553"/>
    <dbReference type="EnsemblBacteria" id="EGN40952">
        <property type="protein sequence ID" value="EGN40952"/>
        <property type="gene ID" value="HMPREF0994_02553"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2797"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="26169" checksum="6E8AC83808C04A03" modified="2011-09-21" version="1">MVNVKGKWALVTGSSRGVGRQIALFMAKEGCNLILHSRSLAHTGKLLEEVTAMGVEAYAVEAELSDPAAVNRMLDEIEEKGTPVDIVFNDAGVQIAYRDNYWETPVEDFTQSFMINTIAPAIICYRLIPKMIERGFGRVINTTSGIRNEPQQAGYSASKAALDKFTTDLASALPEADVMMNLTDPGWLRTDLGGPNAPGAVESCVPGIVVGAFLDDGKSGRLLPAQAFTGMTLEDAVKKAREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9T8</accession>
    <name>F7K9T8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252522.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02621"/>
    <dbReference type="EnsemblBacteria" id="EGN40604">
        <property type="protein sequence ID" value="EGN40604"/>
        <property type="gene ID" value="HMPREF0994_02621"/>
    </dbReference>
    <dbReference type="GeneID" id="29723930"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2874"/>
    <dbReference type="eggNOG" id="COG4469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686598_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010330">
        <property type="entry name" value="CoiA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06054">
        <property type="entry name" value="CoiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="401" mass="46700" checksum="1F27A738E52AAA5C" modified="2011-09-21" version="1">MIFLRKSTGIPGEAGSERESGIEAGMYECAEAVYQNEIWKAASLKDENGNYKQELRLKMKKESQKHCFTCPECGESLILNAGNIRQPYFSHYAGSDCVLTSKEQAERNQLMRQAMLLLAQSSFPDAEIREYALLKGNMRSQLLIMLPDSKIALNYVSDFVKLGRLEDKIACMKEKGMVPVWFTPFRISGREKLTTAEYLISAEQPVLKSIDWLNKLICMKEYDADTDNILWEECYSFAELRLDEEGEFVCREQIEPDERKLQQLRQQEKLEEKLEEERRLRLECGRKAAVCLFRQKEASSAVYEPDQVVLRISKEEYMQQEYAYGQDFFMESFDEYWVLKKLKGGSRERRAAAAVRERFLEYADYELQYERKGEEKGLFLGKVLQILEEVRDSREWLAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9W6</accession>
    <name>F7K9W6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02649"/>
    <dbReference type="EnsemblBacteria" id="EGN40632">
        <property type="protein sequence ID" value="EGN40632"/>
        <property type="gene ID" value="HMPREF0994_02649"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2902"/>
    <dbReference type="eggNOG" id="ENOG502ZCCV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_798651_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="32329" checksum="E7B31A2AD11B6B0E" modified="2011-09-21" version="1">MRGGGIALALSGGIDSAILAKFMPKDSIAYTFKCIVPGIKTTDETVLAAKYAKECGLNHKIVEIYWDDFEKYSPLLMIHKKAPIHSIEVQIYKAFLQAKADGIKTLIFGEAADAVFGGLSSLLSKDWLIGEFIERYSFVLPFYALKEPMLNLEPFKQLETNGIIDPHNFITNVFINESVGSYIHACSVLGMNIGLPYAESFFACDINYEKIRRGENKYLVREVFERLYPDFVIPEKTPMPRPMNEWLKDWSGPVRKEFWPHCAQNMTGDQKWLLWSLEKYMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Y3</accession>
    <name>F7K9Y3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252567.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02666"/>
    <dbReference type="EnsemblBacteria" id="EGN40649">
        <property type="protein sequence ID" value="EGN40649"/>
        <property type="gene ID" value="HMPREF0994_02666"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2918"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="27699" checksum="1EDB96B0CB1C148C" modified="2011-09-21" version="1">MKEIISGKGIIKTFGQGGEKRRVLDGVDISVEEGEFISVMGPSGSGKSTLLYACSGMDSIDGGNISFCGRELSSFREKELADLRRTRMGFVFQQPSLLKNLNILDNIVFPSLRDHRKNAGQLMERAKELMERTGISQLEKRKVTQVSGGQLQRAGICRALMNQPEIVFGDEPTGALNSRASAEIMDLFSEINEQGTAVMLVTHDAAIAARTRRVLFLSDGRVAGELRLPRNSGLSHAAKMDKVLEKMRLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA49</accession>
    <name>F7KA49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40717.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359729.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02734"/>
    <dbReference type="EnsemblBacteria" id="EGN40717">
        <property type="protein sequence ID" value="EGN40717"/>
        <property type="gene ID" value="HMPREF0994_02734"/>
    </dbReference>
    <dbReference type="GeneID" id="29723550"/>
    <dbReference type="eggNOG" id="ENOG5032YTK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400900_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356760" evidence="2">
        <location>
            <begin position="27"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40717.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="194" mass="21220" checksum="B52CB4F1BD6B3E5C" modified="2013-09-18" version="2">MKKGKKTCLLTAVLLVSALLAGCGKNAELDKFYSEMDDFTAQVNISFDNLNSVDPESETGVEDMLAAMDDLAAQFTVLADIEVPRQFSAVEDLADEAGENMTEAARLYREAYADEEYNENVASAALEYYNRAVKRLNYISLILQGEMPTDDSITIITENDAPGFKEDSEGNSDNFDNAGEPENTAEPSDTEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA76</accession>
    <name>F7KA76_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">folD</name>
        <name evidence="11" type="ORF">HMPREF0994_02926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252827.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02926"/>
    <dbReference type="EnsemblBacteria" id="EGN40535">
        <property type="protein sequence ID" value="EGN40535"/>
        <property type="gene ID" value="HMPREF0994_02926"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3193"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="122"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="30167" checksum="31823D7602C617F4" modified="2011-09-21" version="1">MAKIIDGKAVSKAIKDEVKQKVEELQAKGIMVTLAVIQVGNNQASTVYVNNKKKACEYTGIRSLAYELPEETTQEELLALVEELNAREDVNGILVQLPLPSHMDEDAVIRTISPQKDVDGFHPQSVGALCIGQPGFVSCTPAGIIELLKRSDIEIAGKECVVIGRSNIVGKPMGILLLRENGTVTIAHSRTQDLKAVAKRADILVVAVGKAKMITSEYVKPGAAVIDVGMDRDENNKLCGDVDFEDVSQVAGAITPVPGGVGPMTIAMLMHNCLESVKLQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAJ9</accession>
    <name>F7KAJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252726.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02825"/>
    <dbReference type="EnsemblBacteria" id="EGN40434">
        <property type="protein sequence ID" value="EGN40434"/>
        <property type="gene ID" value="HMPREF0994_02825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3092"/>
    <dbReference type="eggNOG" id="COG1534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095994_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="96" mass="10724" checksum="832B4DC7D28C2AA1" modified="2011-09-21" version="1">MTSKQRAYLKSLASSLDPIFQIGKGSLTPEVTEAISEAFNTKELIKIAVLKNCFDDPGEMAQMIAERTKSQVVQVIGKKIVLYKESKDHKKIELPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB20</accession>
    <name>F7KB20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-X-X-Leu-X-X-Gly heptad repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252950.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03049"/>
    <dbReference type="EnsemblBacteria" id="EGN40226">
        <property type="protein sequence ID" value="EGN40226"/>
        <property type="gene ID" value="HMPREF0994_03049"/>
    </dbReference>
    <dbReference type="GeneID" id="29728890"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3330"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018675_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356506" evidence="2">
        <location>
            <begin position="31"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="810" mass="86851" checksum="DADD97932D2B5C6D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB79</accession>
    <name>F7KB79_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253019.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03118"/>
    <dbReference type="EnsemblBacteria" id="EGN40295">
        <property type="protein sequence ID" value="EGN40295"/>
        <property type="gene ID" value="HMPREF0994_03118"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3409"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_4_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="132" mass="14059" checksum="6654EA6C3B55E6FB" modified="2011-09-21" version="1">MEKDTRKDDNRNTYVLQGDESIGSVQIADEVVAMIASLAATEVEGVSAMAGNITNELIGKVGVKSLSKGVKVQVAGNTVKADLALCLEYGYNIPETCSKVQEKVKNAIENMTGLTVTDVNIRIVNVNMEPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB93</accession>
    <name>F7KB93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03122"/>
    <dbReference type="EnsemblBacteria" id="EGN39952">
        <property type="protein sequence ID" value="EGN39952"/>
        <property type="gene ID" value="HMPREF0994_03122"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3414"/>
    <dbReference type="eggNOG" id="ENOG5032YS3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086909_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024232">
        <property type="entry name" value="SpoIIIAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038503">
        <property type="entry name" value="SpoIIIAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12685">
        <property type="entry name" value="SpoIIIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="248" mass="25979" checksum="5A22C0980EA73F19" modified="2011-09-21" version="1">MLKRNQIMITALAIMIAVAGYLNFAGTKAGEEQLTSADAGNAGEDMTALLDLSEEDVVSDIDSMDSDQDGVAAADYLNEQMPANAQVQADSAQVAVVSETMDEASAEQVAEDTDVQNGEVPGEAVFTSSTGVTSLAGAKLQKEQTRAKNKETLLDIINNANISEEQKQDAINGMIALTDMAEKETAAEILLEAKGFNDVVVSISGSGVDVVVNAPSLTDAQRAQIEDIVTRKTGISPENIIISPITGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBE2</accession>
    <name>F7KBE2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253077.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03176"/>
    <dbReference type="EnsemblBacteria" id="EGN40006">
        <property type="protein sequence ID" value="EGN40006"/>
        <property type="gene ID" value="HMPREF0994_03176"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3469"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="373"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="453" mass="49398" checksum="FE77C2A9C8A9C5A2" modified="2011-09-21" version="1">MKIIIAGCGKVGYALAEQLNEEGHELTIIDTNEEKAGLVGNVLDVMCIQGNATSYRVQVEAGVKEADLLIAVTGKDEVNLLCCLIARKAGHCQTIARVRDPGYYAEIGFIKEELGLSLAINPELAAASDIARLIRIPSAMDVDAFAKGKVDLVRFRIPDGSSWSERKISEATKRFGFNMLICVVEKDGSHEVIIPDGNTILHEGDYISVIVPPDKMKALFSSIGIESKMIRDVMIAGGGTLAYYLARMLLESKIQVKIIENNRARCDELSELLPKAMIIYGDASGTDLLREEGIESSDAFISLTGLDEENVMLSCYVGKVSKAKVITKINKINYGGIIDNFDIGSVISPKYLTAEHIIKYVRGMQNSMGSAVEAVYKLIDNKVEALEFFVKKDSKVLNVPLSDLKLKSNLLLCNIVRRGKLILPTGQDSIKAGDTVIVVTTHKGLDDIEDILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBF9</accession>
    <name>F7KBF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CitMHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253094.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03193"/>
    <dbReference type="EnsemblBacteria" id="EGN40023">
        <property type="protein sequence ID" value="EGN40023"/>
        <property type="gene ID" value="HMPREF0994_03193"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3487"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063025_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="370" mass="40724" checksum="94EE72E7585B4E19" modified="2011-09-21" version="1">MEKIRCIIKKDPVLMISGLLAVISAFFIPPDAAYLSYIDFHVLALLYCLMCVMNGFQEIGLFQKLAVFILSRTKNTRQLTAVLVFLCFFLSMFITNDVSLITFVPFTVLILTIIGQTKLMIYVIVLQTIAANLGSMLTPVGNPQNLYLYSLSGMDISLFLKTMLPYTLLSGLMLLLALFLKPGEEVSLQAVFTETKAMARRPLAAYTLLFLLCLGCVLRLIPWQAVLLILLAVLLFFNRRLLLKADFGLLFTFVFFFLFIGNMGRIPAIVGFLRSVLSGHELFLSIAASQVISNVPAAILLSGFTGNYLPLLAGVNIGGLGTLIASLASLISYKQYAGTAGCHKGRYMLYFTVMNLIFLAALAILAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBG7</accession>
    <name>F7KBG7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253102.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03201"/>
    <dbReference type="EnsemblBacteria" id="EGN40031">
        <property type="protein sequence ID" value="EGN40031"/>
        <property type="gene ID" value="HMPREF0994_03201"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3497"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004642">
        <property type="entry name" value="Ser_deHydtase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00718">
        <property type="entry name" value="sda_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="30749" checksum="FFA89583C9E1B4F7" modified="2011-09-21" version="1">MFILDTEKLIQKLKEEGDQPLWEYALNQEMERSGRSREELREQMDQSLAVMERSASTARKEPVQSVSGLTGGNACRYEQYRGKGNSLLGETASLAVGMALSCSEINASMQCIVACPTAGSCGIVPAVLLACAQSRGLDRQTLINALFTASAVGIIVGSRATVSGAEGGCQAECGAAAAMGAAAVTEMLGGTPEMAFHAAAMALKNVLGLTCDPVAGLVEIPCIKRNASGAMNALLSADLALAGVKSYIPFDEVVDAMYAIGKAMPQSVRETSKGGLAVTPTGMRMKKETQRGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBV3</accession>
    <name>F7KBV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03350"/>
    <dbReference type="EnsemblBacteria" id="EGN40180">
        <property type="protein sequence ID" value="EGN40180"/>
        <property type="gene ID" value="HMPREF0994_03350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3662"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="33966" checksum="F79E7CD36A955B4D" modified="2011-09-21" version="1">MAEKQVMESRKVKMGTAAVIFNVIGYILVGLVALICLLPFIMLVSGSFSSEQAIRFTGYGMLPKDFTLEAYKVVFKYPEKIVRAYGVSIFITAVGTGIGLFITTMAAYVISRKDFKYRNAISFFFYFTTLFNGGMVSTYIFYIQYLHLKDNLLALILPGMVNIFYLLIMRSFVSAIPIALVESAKIDGAGEFRTFLQIVLPLLKSGLATIGLFMALGYWNDWYNAMLYMNTSEKYPLQYMLYDLLQQTQALARIASQAGIRVESLPSNTLKLAMAVVATGPIILLYPFVQKYFVKGVTIGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBW1</accession>
    <name>F7KBW1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03358"/>
    <dbReference type="EnsemblBacteria" id="EGN40188">
        <property type="protein sequence ID" value="EGN40188"/>
        <property type="gene ID" value="HMPREF0994_03358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="35847" checksum="32AFEE7B87F25B75" modified="2011-09-21" version="1">MRVRSMASKTDFMKEARLQKQKKLKKYRFLYLALAFIVMYYLLFQYIPILWGFLISFKDFKVGGTIMGAKWVGISNYAAIFKDPDMLRLIRNTLVISCSRLLFTFFPPILLTIAIFDLRNSRFKKLSQTIVYIPHFFSWVVIYGIVYAFFSGNGFINNILFAAGGSRTEFMTSTKAFVPLLVGSQIWKETGWATILYFAALTGVNPELYEAAKIDGAGPLARIRAVTLPAMLPVVTFSLIMAMGNILNNDFEQILLFYNSAVYDVGDIIDTWVYRVGLGKMQYGLGAAVSMLKAVISLFLILVANYTSKKTTGRGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC02</accession>
    <name>F7KC02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6x reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253282.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03381"/>
    <dbReference type="EnsemblBacteria" id="EGN39888">
        <property type="protein sequence ID" value="EGN39888"/>
        <property type="gene ID" value="HMPREF0994_03381"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3695"/>
    <dbReference type="eggNOG" id="COG2099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068627_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN39888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="267" mass="29334" checksum="F4A2AC8CE0B8C4BC" modified="2011-09-21" version="1">MKQKVMLFAGTTEGRLLYEFLEAEGFKAMVFVTTAYGEQLLSHGKEETGGTARIHTGCLDREEMEEQMKAYAPALVIDATHPYASAATENIREASSRVHIPYIRVLRASCPAGDKNREAEKLTEVEDIGSAAAWLEHTEGNILVTTGSKELKELRTLTGFKERVYARILPIPAMLEKCMELGLDGRHIICMQGPFSEEMNYAMLKEVDAAFLLTKESGAAGGFPEKLAAAQRAGAAVVIIKRPGQEEGYSVEQVKKILLAKDENSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCN2</accession>
    <name>F7KCN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253512.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03611"/>
    <dbReference type="EnsemblBacteria" id="EGN39206">
        <property type="protein sequence ID" value="EGN39206"/>
        <property type="gene ID" value="HMPREF0994_03611"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3944"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="32930" checksum="6BCA3264D5BD3631" modified="2011-09-21" version="1">MWRKKSNGDKIFDIMLIIISIVIIIVIAYPLYFVIIASFSKPEAVLGGKLRFLPVGFNVESYKMVLSERKVWIGYRNTLLYTVLGTSINLLLTILAAYALSRKDMPWRTPLTFIISFTMLFGGGMIPVYMVVKNLGLTDTIWAMVIPNAIATYNLLVMKNYFQSSIPEELQEAAAIDGCSHFKTLTKVVLPLSAPIIAVIILFYAVGHWNAFFNAVLYLRNQELNPLQIILRDILLQNSLEAVGGDMSGMYEKVMQGETMKYALIIVASAPVIAMYPFVQKYFVKGIMVGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCR2</accession>
    <name>F7KCR2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253542.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03641"/>
    <dbReference type="EnsemblBacteria" id="EGN39013">
        <property type="protein sequence ID" value="EGN39013"/>
        <property type="gene ID" value="HMPREF0994_03641"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3973"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="393" mass="44038" checksum="62BDD7FB78F0D319" modified="2011-09-21" version="1">MHITEGKTECLPEEAGYHSGRILALDEHFGRMMERREIEGAAYCISKNGKVIAEKGLGLAHYYDHDDSMRPDTIHGIASITKTFTAAALMKLVEDGYTRLDVKVGDILPQFASKPFDGINLFHLLTHTSGLQPDAGCFPNPYFAPVWRYMEEAAKEWKPGEEFDWLTPSMSCGMRRKPGEEWQYCSYGFVVLGAVIEKISGVMAEKYIHDNILSPLGMKDTFFLPADSERLKRIHVTDEEDKEDIKSAVKGEKQCLSSWRDYIPNTGGGLFSTPGDLIRFANMMLGMGQLDGKRILGRKTVEKMTSSVLAHTPDYCWGAEEPDRKYGIGFDRREGPGFLYSKGTYMHEGAGSCSLVIDPAEQLAAAWFVPFRPGEWYADGLWNVSNIIWSGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD21</accession>
    <name>F7KD21_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253651.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03750"/>
    <dbReference type="EnsemblBacteria" id="EGN38815">
        <property type="protein sequence ID" value="EGN38815"/>
        <property type="gene ID" value="HMPREF0994_03750"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="65"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="30827" checksum="C3515C684FECFA8B" modified="2011-09-21" version="1">MKVIKKFFLYLFLIVILLVFIVPFLYALYNSFLPLADVDKLVPFSHFTVDNYVTLFTKYNMARWIWNTVVMTLIIVLGNVWFTTMAGYALAKFDFPGRSFLRFVVIVTMMVPFQLVVTPMYLTIVNIGWNNTMASITVPYVCQCIYVFFAQQYFYSIPKEMEEAARIDGLGRAGVFFRIVLPISKPCLTTIIILCFTGTWNSYFVPATFLTDEKLFPIVVGLNTVKAKYFARPNLSLAGVILLTLPVLVIYIIFQKWFIQGVASSGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD24</accession>
    <name>F7KD24_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253654.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03753"/>
    <dbReference type="EnsemblBacteria" id="EGN38818">
        <property type="protein sequence ID" value="EGN38818"/>
        <property type="gene ID" value="HMPREF0994_03753"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4095"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="408"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN38818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="508" mass="59135" checksum="FA7B5D4A1C255466" modified="2011-09-21" version="1">MKIAIVDDEILVRVGIRSIIEWEKHDCCIIWEAGSGAEALEKYEAERPDLLLLDLTMPGIGGIEVIQRLRGKKERAAIVVISCHEEFALVREALKSGASDYLLKHSLEEGTLLSIIEENRPKQENTEQTAEVLHKDRRRLERFIKTRDEKMLNEDEERKFDRVLFLAFAVPDYDRIRERYENKRENYFQDLVEEVAGRILMRFPNRRFACIQENHFYVMLSCQKEYGEFELLELGRKLQLSLKKFINVSVILGMSGTLKGEGRFRDGLRQAEEALSRHFFEEKKELFLWKPYDAAAMQRQFIALAERFCAACKEAVTAGETQTFYGLLENYEKEMSACQEVGTEYFKRMIQLMLGDIFTLSLAEIQWLAGEVQQAGSVHAAMEIFRKGYEQNLGQFFVPAESDNYLVRQAIGYMMDHYQEQITLKSLAEYLYVSEGYISRLFKAETQTNIFKYLNQIRIGKAKKLLQDHTLKPYQVSELIGFNNRVYFDNVFKSIVGVTPSEYRKGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDC7</accession>
    <name>F7KDC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-ribose pyranase</fullName>
            <ecNumber evidence="2">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253761.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03860"/>
    <dbReference type="EnsemblBacteria" id="EGN38625">
        <property type="protein sequence ID" value="EGN38625"/>
        <property type="gene ID" value="HMPREF0994_03860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4203"/>
    <dbReference type="eggNOG" id="COG4154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120075_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN38625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="146" mass="16264" checksum="1F6A50958A8DD84F" modified="2011-09-21" version="1">MLKGVPKILSPQLLKVLCEMGHSDRIVIADGNFPAESMGKDAIVIRMDGHGVPEILDAVLQVFPLDSYVEKPFSLMEVMPGDDVETPIWDTYEEIEKKYESRGKEAIGHIERFAFYEEAKKAYAIIATGETALYANVMLQKGVVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDE3</accession>
    <name>F7KDE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03876"/>
    <dbReference type="EnsemblBacteria" id="EGN38641">
        <property type="protein sequence ID" value="EGN38641"/>
        <property type="gene ID" value="HMPREF0994_03876"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4219"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356537" evidence="7">
        <location>
            <begin position="17"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN38641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="633" mass="68033" checksum="4E38536CFD39203D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDP3</accession>
    <name>F7KDP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38691.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360309.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03926"/>
    <dbReference type="EnsemblBacteria" id="EGN38691">
        <property type="protein sequence ID" value="EGN38691"/>
        <property type="gene ID" value="HMPREF0994_03926"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035605_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38691.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="314" mass="34618" checksum="93C9FD4B96A86B7E" modified="2013-09-18" version="2">MIERIVEMELPAGEKLIIEKNRIQGERLRPDAARLAIVTGSHGDELEGQYICYETARRLKEGLQFLSGTVDIYPALNPLGIDVVQRTSPLGNVDMNRVFPGSPDGTLLEQAAARIVEDLEGADLCLDIHASDVFVREIPQVRLSEDFAEKLLPYARLMNVDMVWTNATATVHESTLAHAMNSRGVPALVVELGVGNRISPEYGSRIVDGIFNVMNLLGMWKGKHSMVGMPAVSTDGEVEFIRASVNGMFLPSAAHNHYIRQGEKIGEIVDVINGTVKQEIFAHKSGLIFTLREYPLVYEGALLARILTGIEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDQ1</accession>
    <name>F7KDQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253877.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03976"/>
    <dbReference type="EnsemblBacteria" id="EGN38476">
        <property type="protein sequence ID" value="EGN38476"/>
        <property type="gene ID" value="HMPREF0994_03976"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4332"/>
    <dbReference type="eggNOG" id="ENOG5031JM9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154495_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="14894" checksum="5E056C3DDB3E56EA" modified="2011-09-21" version="1">MAVVEELIRAEADGSISFGNHTLAEKAKLEDFSHEGDLYKVKTYQTMTKLEKNGMFVYESVPGTSVLNFLESEDGVSFVVEGQEDAQLTIGLQDDTEYDVRINEEDAGRMCTNLGGKLSLSVELAGAGEVKVDIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDY0</accession>
    <name>F7KDY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253960.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04059"/>
    <dbReference type="EnsemblBacteria" id="EGN37584">
        <property type="protein sequence ID" value="EGN37584"/>
        <property type="gene ID" value="HMPREF0994_04059"/>
    </dbReference>
    <dbReference type="GeneID" id="29729526"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4427"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020013_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363925" evidence="2">
        <location>
            <begin position="37"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="762" mass="83107" checksum="274E58041F90E1CD" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDY7</accession>
    <name>F7KDY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253967.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04066"/>
    <dbReference type="EnsemblBacteria" id="EGN37102">
        <property type="protein sequence ID" value="EGN37102"/>
        <property type="gene ID" value="HMPREF0994_04066"/>
    </dbReference>
    <dbReference type="GeneID" id="29729519"/>
    <dbReference type="eggNOG" id="ENOG50325RR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929972_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="33002" checksum="D407D6B55B10A954" modified="2011-09-21" version="1">MKKKIWEAAVMVLLVLSVTLNLILLCFCLGLKKQNTQLSGEISAIPQQVDASLQTALARIDALQNESQSITSYFSIDFGALEKGMADTKVRFALKEMAAGSTVHVGWYDGEKERTQEARPAENGFFEADLSIPVTCRNGTISLIYNDGNTDTVEIPEPNLDVFSHYLIQWNAYGDLGWHRSGGSLETTFTANAEISSTGPDSNKGSRAMLYLYRNEELLEKTLLFENAYGYSNNGSCIETTLTPEDGDILSLRLVITDTLGYTYKKTLDQLLIPDKGAVPEFDPSFDRAGGMRIIPPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE00</accession>
    <name>F7KE00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253980.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04079"/>
    <dbReference type="EnsemblBacteria" id="EGN37115">
        <property type="protein sequence ID" value="EGN37115"/>
        <property type="gene ID" value="HMPREF0994_04079"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4451"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="424" mass="44963" checksum="DEDA555D706B19B9" modified="2011-09-21" version="1">MKKKKKNLTTVIFIALLCGAFTGLVLNLWVPEGYFRDTVIVNGIFYVIGQGFIRLMQMLVVPLVFCSLVCGSMAIGDTKRLGRVGVKTIGFYLLTTAVAISVAIFLAGLINPGLGLDLGKIQGTETVIAEKTSIVDTILNIIPTNPLGALAEGEMLPIILFALILGVILAHRGEKADTVSSFFSQFNDIMMDMTMGVMKLAPVGVFCLIARTFAGLGLDAFVPLLKYMFAVFLALAVQGLVVYQVLLKLFTGLSPVKFLKKFAPVMAFAFSTATSNATIPLSIDTLHKKMGVSKKISSFTIPLGATINMDGTAIMQGVAVVFAAQAFHIHLSAADFLTVIATATLASIGTAGVPSVGLITLSMVFNSVGLPVEAIGLIMGIDRILDMTRTAVNITGDAVCTTIVAKQDNAVNVEIFNRKDPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE81</accession>
    <name>F7KE81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04160"/>
    <dbReference type="EnsemblBacteria" id="EGN36953">
        <property type="protein sequence ID" value="EGN36953"/>
        <property type="gene ID" value="HMPREF0994_04160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4534"/>
    <dbReference type="eggNOG" id="COG3432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103675_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025374">
        <property type="entry name" value="DUF4364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14277">
        <property type="entry name" value="DUF4364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="156" mass="18257" checksum="AC625E3A315746AA" modified="2011-09-21" version="1">MLDRVTFPLTTAQISEFILEKEYTNFLTLQTAISELTETGLAESRTLLNRTQLQITEEGRNTLHFFENRISDAIKRDIIDYFKNHKLELRNESSIQSNFYKLVNGEFEAQLVAKDKDVDLVNIRISVPTQELAASICDNWQKKNKEIYQYLTEQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEC5</accession>
    <name>F7KEC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254105.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04204"/>
    <dbReference type="EnsemblBacteria" id="EGN36484">
        <property type="protein sequence ID" value="EGN36484"/>
        <property type="gene ID" value="HMPREF0994_04204"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4588"/>
    <dbReference type="eggNOG" id="ENOG5032ZK1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111554_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="158" mass="17779" checksum="7BD4C9307CBD53A3" modified="2011-09-21" version="1">MTKTEFLEALRRALNGNMAAASVEDNLKFYENYFYSEEAKGRSEAAVLSELGDPRILARTLIDAAERAGDAYAREANETQFRAASGAQNRDEYREEAYSQGNGRTVKRVHMPGWLIAILVIMVFVVVISVVGSLMWAILPYLIPVVLVVYIIRLFQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEW5</accession>
    <name>F7KEW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar (Glycoside-Pentoside-Hexuronide) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254302.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04401"/>
    <dbReference type="EnsemblBacteria" id="EGN35711">
        <property type="protein sequence ID" value="EGN35711"/>
        <property type="gene ID" value="HMPREF0994_04401"/>
    </dbReference>
    <dbReference type="GeneID" id="29723357"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4803"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="469" mass="51211" checksum="625502F90C777BDE" modified="2011-09-21" version="1">MSETMTRNKYGSDMEKPVKHKNMASGKEVLGHALGGVGQNTVYALWSGFITAFYTDVFGMNPAVMAGIFLFARIWDAVNDPMMGIMADRSKSRFGRYRCWLLRMPAVVAACLVLNFTVPHFGTMGNIIYAAVTYILMGMAFTSVDIPYWSLPAAMTSDPTERTKIFTTATLGTNLATTVGNMLIPILLVAFGGTGSAHAYFMTAVIFAVVGCSLYLTCFGLVREHVQAPTEKFSFALAFKSLFTNKPLFCIMITNLVINLAFIMKMTLNYYYTTYTLGDVKLMSLMSLITLPSILLGTAAAPFLTKLVGKKKTLLGLMIANLVVSAIFWLVGYGSIPLVLLMGALQILCVGASFVVISSMTADTIEYGEWMTGQRNEGVITSTRTLITKAASALVGVAVAAVLTMTGYVPNVAQSAQTMGAFHFVVSFLPGIVMMIGAIPMFFYSLTEERHAQIMEELKERRAQKERDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG23</accession>
    <name>F7KG23_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254703.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04802"/>
    <dbReference type="EnsemblBacteria" id="EGN34429">
        <property type="protein sequence ID" value="EGN34429"/>
        <property type="gene ID" value="HMPREF0994_04802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="32549" checksum="71017C72B11F1FF3" modified="2011-09-21" version="1">MNRKERFIPSDIPIIIATILIIIFTLYPVIYVVSMSFSEPSHVLARDVYLLPKGFSLKAYRMILDNATVLRSFANTLWYTVVGAAASVTLTATTAFVLSRKRFFLRRQLSLLMTLTMFISGGLVPLYILVQKMHLYNTRWAIVLPYIISAYNLIITRSFFESLPEEMAEAVKIDGGSEWTVMTRIFIPLSKPIISVLILFYGVGYWNSYFAPLIFLSNEKLQPIQLYLRSILITSEVQASGMGLDAVLMNEQMKYAVIVIACFPIMILYPFIQKYFEKGVLIGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGQ6</accession>
    <name>F7KGQ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_rhamnosid6H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05035"/>
    <dbReference type="EnsemblBacteria" id="EGN33744">
        <property type="protein sequence ID" value="EGN33744"/>
        <property type="gene ID" value="HMPREF0994_05035"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341893_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="370"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="793" mass="90145" checksum="08F195FD556C898A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGT6</accession>
    <name>F7KGT6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254966.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05065"/>
    <dbReference type="EnsemblBacteria" id="EGN33098">
        <property type="protein sequence ID" value="EGN33098"/>
        <property type="gene ID" value="HMPREF0994_05065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5533"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="26685" checksum="0D1101FEC5C37755" modified="2011-09-21" version="1">MLEKLIVCIVAGLGAGIGTGFAGMSAAAVISPMLITFLGFPAYEAVGIALASDVLASAISAYTYGKHKNLDVKNGIIMLISVLVFTLVGSFIASKVPNRSMGSFSVVMTFLLGIKFLVKPVMTTKETQADKDTRTKIIQSLLCGALIGFICGFIGAGGGMMMLLILTSVLGYELKTAVGTSVFIMAFTAFTGAVSHFTIGGIPDIPALLLCILFTLIGARLAARFANKASAKTLNRATGGVLTLLGLVMIVMNFLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH18</accession>
    <name>F7KH18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255055.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05154"/>
    <dbReference type="EnsemblBacteria" id="EGN33187">
        <property type="protein sequence ID" value="EGN33187"/>
        <property type="gene ID" value="HMPREF0994_05154"/>
    </dbReference>
    <dbReference type="GeneID" id="29726151"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5633"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="314" mass="35739" checksum="1CDE135DC0AC6C20" modified="2011-09-21" version="1">MNKKLGTAILLTGITTFTIHMINKVQFSFSTVKNILSCPNNKYYEWRFGKIRYIKKGSGSPVLLLHDLTPGSSSYEFSAIIDELAEKHEVYAIDFLGYGLSDKPNITYTNYLYVQSVIDFIKVIIGRKTSIIATGDAAPIGIMACHNDGEVIDKILLLNPQSINKLNQIPNKQTRLLKFLIDTPILGTLLYNIQTTKESFKKVFLEEYFEESVNVKEEMLMSYVEASHLPDFNAKFSFASFTGRYMNANIIHALKEIDHSIYILYGKSKKDIETVVDNYIYFNQSIEAFGIENTKHLCHLEAPSKVMEQINILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH67</accession>
    <name>F7KH67_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569119.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05203"/>
    <dbReference type="EnsemblBacteria" id="EGN33236">
        <property type="protein sequence ID" value="EGN33236"/>
        <property type="gene ID" value="HMPREF0994_05203"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5681"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_21_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="122" mass="14088" checksum="7EEDA8825D16DDDB" modified="2011-09-21" version="1">MGNITFGSFIAEKRKAHKFNLRDTAKHLNIAYGYLCDIEQSRRPAPNGDFVERISAFLNLDKSEHELLLDLAAKSRNTVSADLPDYIMEKDIVRAALRVAKEVDATDEEWQTFMKMLKERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHC6</accession>
    <name>F7KHC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05265"/>
    <dbReference type="EnsemblBacteria" id="EGN33298">
        <property type="protein sequence ID" value="EGN33298"/>
        <property type="gene ID" value="HMPREF0994_05265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5751"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012396_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="464"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="572" mass="63902" checksum="A7AFE1114657D885" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHE6</accession>
    <name>F7KHE6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ORF">HMPREF0994_05275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255118.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05275"/>
    <dbReference type="EnsemblBacteria" id="EGN33010">
        <property type="protein sequence ID" value="EGN33010"/>
        <property type="gene ID" value="HMPREF0994_05275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5760"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="34373" checksum="BFBC03C0E8C959D5" modified="2011-09-21" version="1">MLDVCLLGTGGMMPLPYRWLTSLMARYNGKSIMIDCGEGTQIAMKEKGWSPKPVDIICFTHYHADHISGLPGMLLTMGNAERTEPLLLIGPKGLTRVVNSLRVIAPELPFPIEYMELTEPEHSIDFEGFRIEAFRVNHNVVCYGYSIIIERSGRFQLDKAQALNIPKQYWSRLQKGETIETPENVFTPDMVMGPPRKGIKLTYCTDTRPTEGIVKNAAEADLFICEGMYGEPEKKDKAREYKHMTFLEAADMAKRAQVKQMWLTHYSPSLIRPEDYMDGVRKIFPQAIAGKDGKSIDLLFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHF0</accession>
    <name>F7KHF0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255122.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05279"/>
    <dbReference type="EnsemblBacteria" id="EGN33014">
        <property type="protein sequence ID" value="EGN33014"/>
        <property type="gene ID" value="HMPREF0994_05279"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5764"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="149" mass="16935" checksum="0669BAC2F9A03436" modified="2011-09-21" version="1">MKTEQIESFSPEDTFAFGEQIGRQAVPGQVYTLIGDLGVGKTVFTQGVAAGLGIQEPVSSPTFTIIQIYEEGRMPFYHFDVYRIGDVEEMDEIGYEDCFYGNGLCLIEWANLIEEILPPSYTEIRIEKDLKKGFDYRKITLTRKEANQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHM2</accession>
    <name>F7KHM2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C_GCAxxG_C_C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255194.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05351"/>
    <dbReference type="EnsemblBacteria" id="EGN32792">
        <property type="protein sequence ID" value="EGN32792"/>
        <property type="gene ID" value="HMPREF0994_05351"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5847"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091283_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="134" mass="14388" checksum="8920C8313A61975C" modified="2011-09-21" version="1">MTKKELAIANHDKKYNCCQAVACSFCKEIGVDEETLFKAGEAFGLGMGGMEGTCGAVSGAVMLAGFKNSDGQLNDPKTKAETYKLSREIVRRFEEKNGSLICRDLKGIDTGTVLRTCPGCIEDAVEIVQEVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI16</accession>
    <name>F7KI16_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05518"/>
    <dbReference type="EnsemblBacteria" id="EGN32959">
        <property type="protein sequence ID" value="EGN32959"/>
        <property type="gene ID" value="HMPREF0994_05518"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6032"/>
    <dbReference type="eggNOG" id="ENOG50314Y6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184290_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025464">
        <property type="entry name" value="DUF4315"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14193">
        <property type="entry name" value="DUF4315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="84" mass="9478" checksum="8894E94A1FC8B675" modified="2011-09-21" version="1">MATKIERIDREITKTREKIAEYQEKLKTLEAQKTEAENLEIVQMVRALRLTPEQLNAMLSGGTVPGMAAASADYNEQEDTAHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI73</accession>
    <name>F7KI73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255359.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05552"/>
    <dbReference type="EnsemblBacteria" id="EGN32377">
        <property type="protein sequence ID" value="EGN32377"/>
        <property type="gene ID" value="HMPREF0994_05552"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="32649" checksum="31FC024DCF8BFB19" modified="2011-09-21" version="1">MAGNGKRFCLLANIVLIALCITAVVPFILLVSSSITEEAVINQSGYSFLPKKIDFAAYKYLFMASASIAKAYGMTIVVTITGTAANVFLTMSMGYLLSKKDLAGRNFISFFVFFTMLFSGGMVPSYIIWSQVMKVSNTVFGLICPNLMLNAFNIILMRTYFSTNIPQEINEAAEMDSCSQVDILFRIAVPLSKPMIATVGLFSALAYWNDWINGLYYLTRKKELYTIQNVLNSMASSVQFLKDNVNTSIGLQFSKGIPTLGVRMAIAVIAVIPVLIIYPFFQKFFIRGIVIGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ28</accession>
    <name>F7KJ28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255633.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05857"/>
    <dbReference type="EnsemblBacteria" id="EGN31485">
        <property type="protein sequence ID" value="EGN31485"/>
        <property type="gene ID" value="HMPREF0994_05857"/>
    </dbReference>
    <dbReference type="GeneID" id="29729359"/>
    <dbReference type="HOGENOM" id="CLU_890778_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="312" mass="35333" checksum="5A1AA49F0FB971D9" modified="2011-09-21" version="1">MESMKEGVKRMQGPGRMLAAVLLICAVFTLSSCMDKTAEEVSLTPEELQDFQELLNSADNRNCLTCCYEEPEQISVSEIFYSRFDLGEPVSEEEIRKLGWEETLDSVKFPVERMNEYLTGKFGITLDQVQRKIRLDYLPEYQAYYLNVGDTNLVMAECVSGTRTADIVKILYNTGNGDGFWEISLKEKDGGFLILANVSCSALHNRDYVEQVLAQKDKLLHGEGIHYDFYFSKESGELIYAVDKPTNAVQARTLYFEKGECIAISMEGENEWQEARGAFCSTNGLYIGPTQEYYGDIGRSILEEFEMAKGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJQ3</accession>
    <name>F7KJQ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255871.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06095"/>
    <dbReference type="EnsemblBacteria" id="EGN31449">
        <property type="protein sequence ID" value="EGN31449"/>
        <property type="gene ID" value="HMPREF0994_06095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6674"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="445"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="544" mass="63117" checksum="7EA26C9AB11853E9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJS3</accession>
    <name>F7KJS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_06102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255878.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06102"/>
    <dbReference type="EnsemblBacteria" id="EGN30728">
        <property type="protein sequence ID" value="EGN30728"/>
        <property type="gene ID" value="HMPREF0994_06102"/>
    </dbReference>
    <dbReference type="GeneID" id="29723614"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6684"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010964_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="281"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="682"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN30728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="780" mass="85273" checksum="A187915AA80B6BC2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJT7</accession>
    <name>F7KJT7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255892.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN30742">
        <property type="protein sequence ID" value="EGN30742"/>
        <property type="gene ID" value="HMPREF0994_06116"/>
    </dbReference>
    <dbReference type="GeneID" id="29723931"/>
    <dbReference type="eggNOG" id="ENOG503289V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1600590_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="166" mass="17964" checksum="EE058BFD42BED0D1" modified="2011-09-21" version="1">METRAYVAEGTKVSSVSEMREKCSPTDCLARMILGEAGNQPQNEMIAVAYTANNRLQFPDKFGSDIKSVVLQGDGGQFNGIKSAVALNPTSHSAWSTCLNVAKTFTSKTNQIGHCLWFNTTSTYNANLKANGGKYKFAGTTTALEVVSEVNLGNAHTFFLVEGYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJV0</accession>
    <name>F7KJV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome c-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_06129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255905.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06129"/>
    <dbReference type="EnsemblBacteria" id="EGN30755">
        <property type="protein sequence ID" value="EGN30755"/>
        <property type="gene ID" value="HMPREF0994_06129"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6712"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="293"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN30755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="448" mass="49038" checksum="7523A49CEA122D7D" modified="2011-09-21" version="1">MGLSVETGIPVITVFIQGLLSFFSPCVLPLVPLYVSYLAGGTKTVDENGNVHYPRKKVMVNTLFFVLGVSFTFFLLGFGFTAMGRFFTSNRAWFARVSGIIMILFGLYQLGLFGRSETIEREHRLPFRLDRFSMNPLVALILGFTFSFAWTPCVGPTLGSVLLMASSSASSAKGFLLVGVYTLGFVIPFLLVGIFTGSVLDFFKKKRNVVKYTVKIGAVLLILMGVMTLTGFMNGITSYLSKVQLGGETQQVQETQSADNETEASGENGTAAGMDGNTENASAAETAAEETSKEEKIGAPDFTLVDQYGETHTLSEYKGKTVFLNFWATWCPPCKGEMPDIQKLYEKYGNNGEDLVVLGVANPKTDGYPYNQDGTQEEVEKFLTDNGYTFPVVMDTTGEIFNQYGIRSFPTTFMIDKDGNVFGYVSGALSADMMESVVSQTMSGKRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK94</accession>
    <name>F7KK94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid mobilization pre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006772916.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06273"/>
    <dbReference type="EnsemblBacteria" id="EGN30192">
        <property type="protein sequence ID" value="EGN30192"/>
        <property type="gene ID" value="HMPREF0994_06273"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6876"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035698_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001668">
        <property type="entry name" value="Mob_Pre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01076">
        <property type="entry name" value="Mob_Pre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN30192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="314" mass="36444" checksum="DD7F7981FE1B2411" modified="2011-09-21" version="1">MAQHAILRFEKHKGNPARPLEAHHERQKEQYASNPDIDTSRSKYNFHIVKPESRYYHFIQNRIEQAGCRTRKDSTRFVDTLITASPEFFKKKPPKEIQEFFHRAADFLIGRVGRENIVSAVVHMDEKTPHLHLVFVPLTEDNRLCAKEIIGNRANLSKWQDDFHAYMVEKYPDLERGESASKTGRKHIPTRLFKQAVNLSKQARAIEATLDGINPLNAGKKKEEALSMLKKWFPQMGNFSGQLKKYKVTINDLLAENEKLEARAKASEKGKMKDAMERAKLKSELDNLQRLVDRIPPDILAELKRQQRQHGKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKG3</accession>
    <name>F7KKG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_42 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256104.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06342"/>
    <dbReference type="EnsemblBacteria" id="EGN47950">
        <property type="protein sequence ID" value="EGN47950"/>
        <property type="gene ID" value="HMPREF0994_06342"/>
    </dbReference>
    <dbReference type="GeneID" id="29727501"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6946"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013448_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="1">
        <location>
            <begin position="427"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="673" mass="76808" checksum="7585E2A9ECA739A8" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKQ5</accession>
    <name>F7KKQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256196.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06434"/>
    <dbReference type="EnsemblBacteria" id="EGN47569">
        <property type="protein sequence ID" value="EGN47569"/>
        <property type="gene ID" value="HMPREF0994_06434"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7044"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570824_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="476" mass="54908" checksum="38E15A7544E8936D" modified="2011-09-21" version="1">MKKYLFLDRGIFNGRYMTNAKVELASIQKEGTVFFREDFFADPPRKWEVRYDNGYPNVLYDSKEKIYRCYYTLFIHDRDSENTPLKERAAKTYVPGSDRVTALCYACSTDGIHWEKPELGLVDFKGNKRNNILYAYVHGTGVFLDEEEPDPNRRYKLVTKVDYAPGCGYMAVGFSADGIHFGELKKWTGGQPRADTHNFVFREERTGRFVLITRIWKNGQRIAARCESSDFLNWTEPQEIFRGRGFEDQIYSMPVFRYNDIYLGVPSVYHEGDTADKDYDTVDLRLAWSVDTLDWEEVAFGENFMDRGKGTYPDGEFDCGCIYSSAPVPIGDRLYFYYMGGNGRHTDYRETSFSRGYIPKDCFAYYRQKDPMREAVLSANPFFFRSSRLELLTERGRSGSILAELTDEKGRICLTGKTEDTGTEPEGNAGSGEPRWETVLWDGTIPEEGKIYTLRIRFSDVFLYGMRGDMEAAGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLA0</accession>
    <name>F7KLA0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ORF">HMPREF0994_06629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256383.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06629"/>
    <dbReference type="EnsemblBacteria" id="EGN46858">
        <property type="protein sequence ID" value="EGN46858"/>
        <property type="gene ID" value="HMPREF0994_06629"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7251"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN46858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="344" mass="39061" checksum="2325C438D2302D65" modified="2011-09-21" version="1">MEELKTSDFYYDLPPELIAQDPLEDRSSSRLMVLDKETGEVSHHVFREIGNYLEPGDCLVLNNTKVIPARLMGIREETGGAVEVLLLKRRENDIWETLVKPGKKARPGTKLVFGNGLLHARVLEVVEEGNRLIQFQYQGIWEEVLDQLGEMPLPPYITHKLQDKNRYQTVYAKYEGSAAAPTAGLHFTTELLQELEQKGVDIAYVTLHVGLGTFRPVKVDNLKEHHMHSEYYQVTREAADKINKAKENGHRVVCVGTTSCRTVESACDENGHMEECCDNTEIFIYPGYRFKVLDALITNFHLPESTLVMLVSALAGREHVLAAYEEAVKEKYRFFSFGDAMLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLE2</accession>
    <name>F7KLE2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256424.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06671"/>
    <dbReference type="EnsemblBacteria" id="EGN46595">
        <property type="protein sequence ID" value="EGN46595"/>
        <property type="gene ID" value="HMPREF0994_06671"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033VN7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141450_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="109" mass="12711" checksum="73793A2F0B91B9D3" modified="2011-09-21" version="1">MINIDLDNVNEEAVYRAFNVEGNEAEALNDSYLELFELIGRDAMLKLFKYFRGDKIDCPMRLYRPEFIADLAKQTTDRRERAKIARAGGYTAKFIEGVLNKRRKENETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLG1</accession>
    <name>F7KLG1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="5">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trpA</name>
        <name evidence="7" type="ORF">HMPREF0994_06695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256448.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06695"/>
    <dbReference type="EnsemblBacteria" id="EGN46619">
        <property type="protein sequence ID" value="EGN46619"/>
        <property type="gene ID" value="HMPREF0994_06695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7322"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="27735" checksum="86F4329F45E150A7" modified="2011-09-21" version="1">MSKIKNAFQNGKAFIAFLTAGDPSADKTVEYILDMEEAGADLVEIGIPFSDPTAEGVVIQEANIRALKAGMTTDGVFDIVRRVREKSQMPLVFLTYLNPVFHYGYDAFFEKCRELSVDGIIIPDLPFEEKGELAPIAASNGVDLISMISPTSEERIRKIAEDAAGFIYIVSSMGVTGVRSQITTDLSSIVNMVRKVTEIPCAVGFGISTPEQAEKMAAVSDGAIVGSAIVKIIAANGANAGEALKEYVRSMKEGVRAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLJ2</accession>
    <name>F7KLJ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256483.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06730"/>
    <dbReference type="EnsemblBacteria" id="EGN46654">
        <property type="protein sequence ID" value="EGN46654"/>
        <property type="gene ID" value="HMPREF0994_06730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7358"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="32264" checksum="61513BFE58FEE3DA" modified="2011-09-21" version="1">MTIRHMEILKAISETGSFTKAARLLYITQSAVSHAVQELETEAGTLLFDRLSKTIRLTEAGNLLLQEILPLLDSCKAVESKIKQLDRRAPIRIVSSITIASYYLPDALHRFEASHPDIPVYVNVVSAANAIEVLQAGNADIALVEGLPPNGPYQSTPFSSYPLLTLCSPDYPHSRQPLSPSALTEERLLLREKGSAIRDVLDSALYLYGFTAHPLWTSVNSPALIEAAKAGLGITILPDILVKDALNEGSLISLETEGLSLINQLLLVTHKDKYLTEPLAELIRIMVPDEMQATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLK5</accession>
    <name>F7KLK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256496.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06743"/>
    <dbReference type="EnsemblBacteria" id="EGN46667">
        <property type="protein sequence ID" value="EGN46667"/>
        <property type="gene ID" value="HMPREF0994_06743"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7370"/>
    <dbReference type="eggNOG" id="COG1378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072493_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="242" mass="27264" checksum="6219F0261F030C5B" modified="2011-09-21" version="1">MDEMSYIEKLMVFGLTRQEASIYLCLYRNGTLTGYEAAKLTGISRSNVYNALAGLAEKGAAYLMEGSSSKYMAVPVEEFCDNKLRMMGNTKQWLSDNMPAADEPSDGYITIMGEQQILDKMHHMMEQAEKRVYLSASGTRIAEMEQDIYELLQKKIKVVLLSDKIPERLKTAVCYKTEGKENQVRLISDSKYVLTGELTGSSRDICLYSGQRVFVDALKEAMRNEIKLIELTGKKKKAKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLN5</accession>
    <name>F7KLN5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flp1_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06764"/>
    <dbReference type="EnsemblBacteria" id="EGN46356">
        <property type="protein sequence ID" value="EGN46356"/>
        <property type="gene ID" value="HMPREF0994_06764"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7390"/>
    <dbReference type="eggNOG" id="ENOG5033BI9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189990_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031564">
        <property type="entry name" value="Flp1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16982">
        <property type="entry name" value="Flp1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Flp1_like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="70" mass="7684" checksum="5254343913930301" modified="2011-09-21" version="1">MKKIYWRTVNGAVHMKNRVGEILKGEEGMGTVEVILIILVLIGLVIIFKNQLTSLVNSIFGKITSQAGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLY6</accession>
    <accession>F7K3R9</accession>
    <name>F7KLY6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00498</name>
        <name evidence="2" type="ORF">HMPREF0994_06865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN45409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48216.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256600.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00498"/>
    <dbReference type="EnsemblBacteria" id="EGN45409">
        <property type="protein sequence ID" value="EGN45409"/>
        <property type="gene ID" value="HMPREF0994_06865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN48216">
        <property type="protein sequence ID" value="EGN48216"/>
        <property type="gene ID" value="HMPREF0994_00498"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7496"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN45409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48216.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="432" mass="50322" checksum="964C91A55C4EC1ED" modified="2011-09-21" version="1">MGTKLERIAEISATTPKPEFTSLYHLINAEMLRQCHRESDGRKAVGIDKVTKAEYEEHLEENITNLVGRLKNKAYKPLPSLRVYIPKSNGKMRPLGIASYEDKIVQLAVKKILEAIYEPRFLNCMYGFRPNRGCHDAIKEVHHRIQNDWINYVVDADIKGFFDHMSHHWLMEFLKLYIKDTNLLWLINKYLKAGIITEGVYEDSEEGSAQGNIISPMLANIYMHNVLTLWYKFVVLKETSGKSFLAVYADDFIAGFQYKADAERYYAMLEERLGKFNLELEESKSRLIEFGRFAESNCKRRGGGKPETFDYLGFTFYCGKGRKSGNFCVKLKTSRKKHMQKLTAIKEWLNDNNDLPAKELIGKLNRKLIGHYRYYGVSFNGKKITAFLHYTQRYLCKALNRRSQMKSYTWEGFIDMLKVYPLAKPKIYVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS56</accession>
    <name>S2KS56_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07271"/>
    <dbReference type="EnsemblBacteria" id="EPC05122">
        <property type="protein sequence ID" value="EPC05122"/>
        <property type="gene ID" value="HMPREF0994_07271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100170_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="169" mass="19615" checksum="02CF3C85956B58A9" modified="2013-09-18" version="1">MPPKAKLSKEEIIETAFEMTRENGFEHVTARELAHRLGCSTQPIFHVFQNMEEVKKEVYERTRVFFTKEMMENPDGEPLFLYMGLRYVELAGQEKNLFRLLCMSDSFRMNSIYELAGAVPEQADARLFVKVWVFTHGIASIAATNTTSLPREEIRELLIEVYKEFAHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS84</accession>
    <name>S2KS84_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359741.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06977"/>
    <dbReference type="EnsemblBacteria" id="EPC05309">
        <property type="protein sequence ID" value="EPC05309"/>
        <property type="gene ID" value="HMPREF0994_06977"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="543" mass="63516" checksum="FA7717FFA1B87706" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS91</accession>
    <name>S2KS91_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360163.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07212"/>
    <dbReference type="EnsemblBacteria" id="EPC05157">
        <property type="protein sequence ID" value="EPC05157"/>
        <property type="gene ID" value="HMPREF0994_07212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="475" mass="52926" checksum="DB2A44DA8CF790EE" modified="2013-09-18" version="1">MDIKKNDILTVEITDTGTEGEGIGKLALPAPDAADTEEKAGGKAAGFTLFVKDAVIGDTVQVKVMKAKKNYAYAKLEKVLVPSPFRVQPPCAFHRQCGGCQLQSLSYEKQLEFKQNKIRNNLVRIGGFDPEKIDACMEPIIGMEDPWHYRNKAQFPFGYDKEGNVVTGFYAGRSHTIIPNTDCALGVEENQEILEIILRFMKKYGVSAYEEVSGKGLLRHVLIRKGFASGQLMVCLIINGKKLPEEQRLADELWKIPGMTSVSVNVNMERTNVIMGKKVRVLKGEEKIEDSIGDVVFRISPLSFYQVNPVQTRKLYGQALEYAGLTGEETVWDLYCGIGTISLFLAQKAKKVYGVEIVPEAIADAKENAVRNGITNAEFFVGKAEEVLPRKYEEDGVYADVIVVDPPRKGCDEKCLETMVRMRPGRIVYVSCDSATLGRDLKYLGENGYEMVRWRGCDMFPGTVHCEVCVELGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJX5</accession>
    <name>S2LJX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359938.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07092"/>
    <dbReference type="EnsemblBacteria" id="EPC05243">
        <property type="protein sequence ID" value="EPC05243"/>
        <property type="gene ID" value="HMPREF0994_07092"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RUT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1413558_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025648">
        <property type="entry name" value="DUF4358"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14270">
        <property type="entry name" value="DUF4358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004498814" evidence="2">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="192" mass="21034" checksum="42E5106551D95E48" modified="2013-09-18" version="1">MRKKAGWRGLFACLAITAFVLGGCGKAAGETETQAVSMKEDRPGADEAAQEAGNEGGAEESKAEEAKSVQDIYEEITQKVELCSPVTMTDSFISNYYGIDPDKLEEYVFSMSEDATSAETIIIMKVRNEADTEEISAALETVRDEKSGEMKDYLPAQFEIVDKSSVKTEGSYVYLVISERADEIIRVIRVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2X4</accession>
    <name>F7K2X4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250152.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00203"/>
    <dbReference type="EnsemblBacteria" id="EGN39236">
        <property type="protein sequence ID" value="EGN39236"/>
        <property type="gene ID" value="HMPREF0994_00203"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.215"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067283_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="35035" checksum="DA8377C393BBD26B" modified="2011-09-21" version="1">MAYGTGGCVKKRTKKVSKGQTEKKTPGKNSIHHEDLALKTAAQYFGEELMPLLGIKGVAGYIAPTETVILEARQMYQDFNYVMTDAAWIHLEFESDAVTKEDLERFREYEAAVSRANHVEVITYVICSAKIRHPRSVLRTGINLYRVKTVQLKGKNADRLFRRLKEKAEQGEELTKADLVPLLLTPLMSGSLRIEERIIKSLRIIQKAGEVLTELELNKTQAVLYTLADKFLTETELGRVKEMIAMTKLGEMLVEDGIRKGMERGIEKGIVETCRELGVSFEDTTEKIKQRFCISETDAREIVKKYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K307</accession>
    <name>F7K307_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250185.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00236"/>
    <dbReference type="EnsemblBacteria" id="EGN37875">
        <property type="protein sequence ID" value="EGN37875"/>
        <property type="gene ID" value="HMPREF0994_00236"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.256"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN37875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="33865" checksum="CF68EB30354A6492" modified="2011-09-21" version="1">MFEVEVKAILSGGNGMNLYRGCTHGCIYCDARSSCYQVHPDRPFEDIEVKRNAAELLEQALRGKRKRCMIGTGGMSDPYLHLEKRLGLTRRCLELIDEYGFGVAIQTKSDLILRDLDLLKRINRKTKCVVQITLTTYDEDLCRVIEPNVCTSRRRAEVLEILRDEGIPTVCWMTPVLPFINDTEENIRGLLEYCCRAKTYGILTFGMGVTLRDGDRQYFYRKLDEHFPGLRERYVKTYGDAYEVPSPNQAELMKLLRRVCKEQGIVCDADEIFRYLSRFEDKLAGTQMSLFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K354</accession>
    <name>F7K354_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250232.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00283"/>
    <dbReference type="EnsemblBacteria" id="EGN33424">
        <property type="protein sequence ID" value="EGN33424"/>
        <property type="gene ID" value="HMPREF0994_00283"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.306"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094015_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="179" mass="21225" checksum="97C687AE86123F9C" modified="2011-09-21" version="1">MQYAIELYYDKETEQKLFNLAKRVADEKLSTKFLEWKTRPHLTLACFNDVNETKCIQQLNNFAKTHKTMPAYIGSIGMFNDTRTIFASPVMNDSMYQFQRELHEYLQDFDITGWEWYCPDRWVPHCTLALTKEDDEEVFYKASDLILHEFRKMSGKFVSVGLVKISFPVEEIYTIELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3W7</accession>
    <name>F7K3W7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250495.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00546"/>
    <dbReference type="EnsemblBacteria" id="EGN44734">
        <property type="protein sequence ID" value="EGN44734"/>
        <property type="gene ID" value="HMPREF0994_00546"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.594"/>
    <dbReference type="eggNOG" id="ENOG5033ABJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276206_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="92"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="212" mass="24645" checksum="744AF4B8D2B9F2BC" modified="2011-09-21" version="1">MIDLSEGYIGSSCVVKAKNNDLLMMGTLHRIKTSFIDISSTRNELPVISYNLFVKVEVYNARLGFRVLIGRVYISNQELIRIIDLNEATNDERREYFRISTRRDGIIFNLTHPLPDGTIKEYQDFKVSLVDISLGGLMFRTKEVLGVGETFSIVIPAMKENMLYECTIRRSVEKPENYIGYGCEFSEMTNLQEDILYRYILRCQNEQLKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Y3</accession>
    <name>F7K3Y3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_00562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250511.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00562"/>
    <dbReference type="EnsemblBacteria" id="EGN44750">
        <property type="protein sequence ID" value="EGN44750"/>
        <property type="gene ID" value="HMPREF0994_00562"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139638_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02473">
        <property type="entry name" value="flagell_FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN44750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="151" mass="17872" checksum="538AAA9B5AEA34A2" modified="2011-09-21" version="1">MKKFNFPLERMLNYQEQDLEKERGIMSRLLAARTGLEEKRLRLMEEMEEIQSERGKEIRKGTTIFSLRSSSVLLVSGKKQLEEIRNELNRIDEEIEKQRQIVVSVSQEVKKLENLKEKQLEEYRHAEAKEEQEMISEHVSGSFVRNGVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K425</accession>
    <name>F7K425_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flg_hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250565.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00616"/>
    <dbReference type="EnsemblBacteria" id="EGN44804">
        <property type="protein sequence ID" value="EGN44804"/>
        <property type="gene ID" value="HMPREF0994_00616"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033MET">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717261_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="385" mass="42317" checksum="2436FC0D2252653C" modified="2011-09-21" version="1">MVSDVSAMMNTVSQASNRPSSERPQQTDSYHDMMKNMLKEQKRIKEEKKPGSDSDSTKVNAKEKPDKDEEGKKPAETDGSAVFLPPGNGEFQSVLWMQQPAAMGDAVPETGLQPVDEGNVAAVMAEMQTETVDEAAEGPMVGNQPEKPEGKEFLSEPAFTVPENDIPEEKSAAVTVPVQISEGKDEDVSDLQTAVNMQTEVENVSENENLSEKRVDENAQLYAQADVKAADDRIVQQGPQTEMPVTQETPESPEEMFQTLPKEIFTRISAGEKEFTVQLEPENLGKLMIKASYADGKASISIICTNEKTMELLSGHAREIGGIMESNLGTPTTVLLDKTEPDYLEQGQDGQNGRQENARDDEGRDKKEQKKNGLDFLHQLRLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K446</accession>
    <name>F7K446_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDOD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250586.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00637"/>
    <dbReference type="EnsemblBacteria" id="EGN44825">
        <property type="protein sequence ID" value="EGN44825"/>
        <property type="gene ID" value="HMPREF0994_00637"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.690"/>
    <dbReference type="eggNOG" id="COG3434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044951_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="198"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="441" mass="51285" checksum="B5BD201439541EBC" modified="2011-09-21" version="1">MKIYAARQPVFDSTGKLFGYEFLYRDSDRNEFNMEIDGSMATCLLLSNMLSEFGLENLTGGVYAFVNLTQELLRNEYISIMDPKHFIIEILEDINDDSNLESTLAAFREKGYVFAMDDYTGEDNKDRLISVSDILKVDFRLTDKKVQKTIAQKYKDSKILLAEKIETEEEQKWAVDNGYSLLQGYYYSKPVLLSKEKTEIALTTYMRLLKEFSKPDTDFTKLAEIIMMDVNLSYKFLMRVNTLQYGGKYRVKTVKQSLVRMGLIEVRRWTLAILLSDVFGKKDNETAKRALIRGVFAEKLVSLMKRVDLEEEAYLVGMFSTIDITVRDNLENLLKQIKVSDESREALFFRSGILGEVLNFVEDYENGRWDKLNEFMRKNKLKQSKISYVYFEAVKYAEIMFEEYGRGGIGDYGSFMQNKSPLIEMLNKQRSREMKEGEADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7K478</accession>
    <name>F7K478_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_00670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250619.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00670"/>
    <dbReference type="EnsemblBacteria" id="EGN44858">
        <property type="protein sequence ID" value="EGN44858"/>
        <property type="gene ID" value="HMPREF0994_00670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.726"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN44858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="223" mass="25178" checksum="AC991C5203A1D066" modified="2011-09-21" version="1">MQHIMIIEDETNIREELMLLLESVPYRVSAPKPEGDLLTLIREARPDLILLDLGLPGIDGLTLCSLLRKESAVPIIFVTGRNTSMDELNCLLRGGDDFLSKPYQPAILLARISAVLRRTKREEDAALHWKNLKLDLASGTISLPEGKSHPAELSRNELKILYYLMKHAGKIVSREELVDYLWDEEIFIDDNALSVNMTRLRSKLESIGAPDFIGTRRGLGYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4M2</accession>
    <name>F7K4M2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250754.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00805"/>
    <dbReference type="EnsemblBacteria" id="EGN43514">
        <property type="protein sequence ID" value="EGN43514"/>
        <property type="gene ID" value="HMPREF0994_00805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.878"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521617_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="501" mass="57965" checksum="04A46C659FE31305" modified="2011-09-21" version="1">MQFYEKLIFLLNLTQTSNRMLAHELQVDPSLISRLRTGTRGVPHNREHIKVMSSYFARKCTTEYQRQALSGMLGIKLALTMKTEQLSEILYYWLCGDADEVGRFMRTFETFLVGEVDTSQKIESCDLKADNMAYYGKEGKRAAARAVYQHLLSMEKPCTVFLYSDESDDWISEDFDFHNNLQLWGLTLLQRGFRFCQIAPPAVSADMAFESLIRWTPLYMTGQVDAYFYPRLRDNVHRRTLLVIPGEIAMTSDSVASQRDCTATILTADSRLTESYMVQFQEYLSLCRPMQRIYTRPEQLMQCFTQFLSLNGARIQMVTSLSAETAPPELMTYCMEKIQQPNLKKLGGMYLQELDLIEENRENFEFIDIAYLAGAQEVRDGKVPIILSYGDNDMPLYYTPETYVLHLKNILEILKSNDNYHFIPLNTQTEENGTIMLKDIQRALLVRTTPPLTVFEISQPDIIQLFREHLFKIANRIGYTGVSRSKIMSQLKERIRELQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4M5</accession>
    <name>F7K4M5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epoxide hydrolase domain-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250757.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00808"/>
    <dbReference type="EnsemblBacteria" id="EGN43517">
        <property type="protein sequence ID" value="EGN43517"/>
        <property type="gene ID" value="HMPREF0994_00808"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.881"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="201" mass="23041" checksum="38A6252DEF737294" modified="2011-09-21" version="1">MIRTIIFDIGNVLTVFGWKNFLHSFGFPPEIEERVGKATVDNPFWHEFDKGFLSDEEMLEGFIRNDPSVEKELREIYVSLHGIVTKADYAIPWIQALKKAGYQVLVLSNFSDKVRRENGDALDFLEYVDGGILSYKDGVIKPDPAIYSLLLERYGLKPEECVFLDDMQPNLDAAARFGIHTILFRSYEEAQEELKKLGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5J9</accession>
    <name>F7K5J9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251077.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01128"/>
    <dbReference type="EnsemblBacteria" id="EGN42890">
        <property type="protein sequence ID" value="EGN42890"/>
        <property type="gene ID" value="HMPREF0994_01128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019175_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="653"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="752" mass="87197" checksum="102B3DCE42BADC5F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6K5</accession>
    <name>F7K6K5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251464.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01515"/>
    <dbReference type="EnsemblBacteria" id="EGN41989">
        <property type="protein sequence ID" value="EGN41989"/>
        <property type="gene ID" value="HMPREF0994_01515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1653"/>
    <dbReference type="eggNOG" id="COG3679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140243_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="108" mass="13100" checksum="95303FFCAD38A762" modified="2011-09-21" version="1">MMEVQEALEQLAQAVKESEVYREYRRQSERVDNAGDMREKIDEYRVRNFELQNSVQTEDLLDKLDDFEREYEKFREDPLVEEFLDAELAFCRMMQEIDVKLAEAMDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6M5</accession>
    <name>F7K6M5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_01535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251484.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01535"/>
    <dbReference type="EnsemblBacteria" id="EGN42009">
        <property type="protein sequence ID" value="EGN42009"/>
        <property type="gene ID" value="HMPREF0994_01535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1674"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN42009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="238" mass="27064" checksum="F5DF67CA42A235E4" modified="2011-09-21" version="1">MQKIFVIEDDENIRNLVKIALEGYGYQVLAFETAEEALELVGKEQPDLAVFDLMLPGMDGLSAIRLIRNRDDEIKNIPIIVLTAKDKEYDKVVGLDGGADDYVTKPFGVLELAARIRSLLRRSAEQQPVHGTGKIKMGGLAVDTAAREVVMNGETVSLTYKEYELLMYLIDNRTRVVERDELLNKLWDYSADIETRTLDIHIRTLRQKLGEEGSKYIKTIRSVGYRFVIPQENDNKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6T1</accession>
    <name>F7K6T1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_01598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009004414.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01598"/>
    <dbReference type="EnsemblBacteria" id="EGN42072">
        <property type="protein sequence ID" value="EGN42072"/>
        <property type="gene ID" value="HMPREF0994_01598"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1747"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_0_2_9"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN42072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="32952" checksum="710BC9DF1AA11481" modified="2011-09-21" version="1">MKISELYQAKQNQGNPSKKTLSFEIFPPKKDSELKNIDKTLAVLCELNPDYISVTFGAGGGANRNRTIELAKRIKQEYHVEPVVHLTCLHYDKAEIDEFARVLANAGLQNVLALRGDKNPDMREKESFCHASDLIAYLKGKWDFCFLGACYPECHPESEDKVGEIRHLKAKVNAGAEVLLSQLCFDNHAFFRFQEACRIADIQAPIIPGIMPVINAAQIKRMITMCGATFPVQFQKIIQKYESNKEALFDAGMSYALSQIIDLLVSDVEGIHLYTMNNPLVARRICEGIRNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6U7</accession>
    <name>F7K6U7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_01614</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009004429.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01614"/>
    <dbReference type="EnsemblBacteria" id="EGN42088">
        <property type="protein sequence ID" value="EGN42088"/>
        <property type="gene ID" value="HMPREF0994_01614"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1762"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN42088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="704" mass="78344" checksum="7A3552DBED357594" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7C8</accession>
    <name>F7K7C8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein cas5, subtype I-b/hmari</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251670.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01757"/>
    <dbReference type="EnsemblBacteria" id="EGN41570">
        <property type="protein sequence ID" value="EGN41570"/>
        <property type="gene ID" value="HMPREF0994_01757"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1918"/>
    <dbReference type="eggNOG" id="ENOG502ZBNI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100173_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013421">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_HALMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02592">
        <property type="entry name" value="cas_Cas5h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="234" mass="27507" checksum="C9EDA4F7F0639A5C" modified="2011-09-21" version="1">MEILKFNLKGSHAFFKVPEVNTYYYFTYGNIHKVALLGMLGAIMGYKGYQMEDKDYPEFYEKLQYLNVSIVPEQKQGYFQKKIQVFNNSVGYASKEAGGNLIVKEQWLENPEWTIYIQIKDEESRELAERIMARKCTYMPYLGKNDHMADISGMCIVSGEERFPKNETADSLVPEGAVQFDWDDMTYRYEEYLPVGLKESTNLYRTHRFIFTDAEMDQCMQPVYKVEGRNLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7F0</accession>
    <name>F7K7F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251692.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01779"/>
    <dbReference type="EnsemblBacteria" id="EGN41592">
        <property type="protein sequence ID" value="EGN41592"/>
        <property type="gene ID" value="HMPREF0994_01779"/>
    </dbReference>
    <dbReference type="GeneID" id="29727186"/>
    <dbReference type="eggNOG" id="ENOG5033QCA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823502_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="345" mass="37130" checksum="FB4911E9463B9932" modified="2011-09-21" version="1">MGCGIWYQLKSCVRDKMCILSFLLPVIAGIALNFLGDVDLLDLAEPEFGVVKENLTSPEIRDWLEGLGTVKEYLSEEELREAVLEPSTSVLGIRQQGGGISVTRAGDEPEMIQKLADRLSLLYEERDRISTVSVSMAVPEGDTGLKNLFISIIMVTAMFMGGTFSAMNILGEKEDGTILVNDVLPRSRLVYLFQKIAVGLLGGILSAGLTALVCIRPLRMIQLPGLTAVILLSAFLASLAGAFTGRAAEGLMAGIGLLKLVMIGFIAPPILFWLLLPAGSRGNGLACLVPSVPAFRGIMELLEGGSFPAVYILLLSVHCVVWLAVYLWTEMAGEKRKRCKGGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7K4</accession>
    <name>F7K7K4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251746.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01833"/>
    <dbReference type="EnsemblBacteria" id="EGN41646">
        <property type="protein sequence ID" value="EGN41646"/>
        <property type="gene ID" value="HMPREF0994_01833"/>
    </dbReference>
    <dbReference type="GeneID" id="29727595"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="114" mass="13486" checksum="FF6F246C55403530" modified="2011-09-21" version="1">MALNMHKEELDSIINEYISEIKKILGADLKRAVIYGSYARGEYEEESDIDIALFTLKKPEEFYLLINKISELTFEYNVKYDIILSPVFQNIIDYNRMLRVVPYYQSIQKEGYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7V1</accession>
    <name>F7K7V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251910.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01997"/>
    <dbReference type="EnsemblBacteria" id="EGN41402">
        <property type="protein sequence ID" value="EGN41402"/>
        <property type="gene ID" value="HMPREF0994_01997"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2193"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="35"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="227"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="313" mass="34763" checksum="BF966AC244D37340" modified="2011-09-21" version="1">MREDISKVLENVGKVIIGKEEVLEKLLAGLLAGGHVLLEDVPGTGKTKMAKALSASLGVDFGRIQFTPDMLPADITGMHIYSRETESFVWKEGPVFTNILLADEINRATPRTQAGLLECMEERQVTVDGETRKMDAPFFVIATQNPVETAGTFPLPEAQTDRFIMKLSMGLPDREEEIRILETYKDKDPLPELKPVMSKKELLSIKEEAERVYVHPLVNGYLADIALATRKQEKIVMGVSPRGTLALMRCAKARACMEGRAYVIPDDVKKLASSVLAHRLVFSFGRSRQEEAVKLLEDILAAVPVPVEDFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K889</accession>
    <name>F7K889_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system, ascorbate-specific IIB component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251775.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01862"/>
    <dbReference type="EnsemblBacteria" id="EGN41267">
        <property type="protein sequence ID" value="EGN41267"/>
        <property type="gene ID" value="HMPREF0994_01862"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2040"/>
    <dbReference type="eggNOG" id="COG3414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159248_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="96" mass="10604" checksum="44BCC65A15C7125C" modified="2011-09-21" version="1">MGMIKIQAVCGFGCGSSLFLKMKIQEVLKENDLEAEIFCGDVGTCTSTPCDVIFTSEELAARVAERSTVPVVTICNFVNKKEVTEKTLEFFRSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8U5</accession>
    <name>F7K8U5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252205.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02304"/>
    <dbReference type="EnsemblBacteria" id="EGN41211">
        <property type="protein sequence ID" value="EGN41211"/>
        <property type="gene ID" value="HMPREF0994_02304"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1832097_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="139" mass="16110" checksum="BDDB651DE9A0E5EF" modified="2011-09-21" version="1">MKTANLVVVLDKENKSVLLCKRRKNPYKGLLNFVGGKLEPDEDSAAAAYRELREETGVTDADISLTHLMDLTYFTWDLKLEVFFGWLNKSVSLKEEVNELLWVDKEQNYFDMSHFAGEGNMGHIMEQIKQYEEEQAFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9A4</accession>
    <name>F7K9A4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40850.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359765.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02451"/>
    <dbReference type="EnsemblBacteria" id="EGN40850">
        <property type="protein sequence ID" value="EGN40850"/>
        <property type="gene ID" value="HMPREF0994_02451"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40850.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="354" mass="39815" checksum="A649DBC1F68001F4" modified="2013-09-18" version="2">MGQDKYVAYVSAYTTGDRSEQGITVYDVDMQKGRFTEKEKIKITNSSYVTISHNKRYLYSITDFGVESYRIKEDGGLQVINMGSINGMRGCYVSTDYEDKYIFVAGYHDGKLTVLRINDDGSVGEITEEIYYKGLGIVAERNFRPHISCAKMTRDNHYLCVADLGMDHTNVYRLDHVSGKLKLVDVIRSDLESAPRHLKFSKDGKFLYIVHELKNCIDVYTYKEEKDNPFFEKIQSVSTLNNYHAGGSTASALNLSDDFRYLCSSNAGDNSAAIYKIDEKTGLLTKLLCLPVSGEYPKDVALFPDNKHLVSLNQDSGTLTFFTTDLEKGLLVMNGPEMKVAQPNCVIFHKVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9D2</accession>
    <name>F7K9D2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252387.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02486"/>
    <dbReference type="EnsemblBacteria" id="EGN40885">
        <property type="protein sequence ID" value="EGN40885"/>
        <property type="gene ID" value="HMPREF0994_02486"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="24480" checksum="A66C605A513EE6DC" modified="2011-09-21" version="1">MSRHAGSVPEETKTRLLQSAVLEFSEFGFEKASLRRICSRADVTTGALYFFFQDKEDLFGHVISPVTDRLLSLMKEHYERELASSSFSIAKDESEDFRAAEEVFELFFDNPAICSIILNNREHPLVCSFFDTLIQMLDYQTVQLLSQAKPPLPENSYFNDCTIHWFSHLQIDAVLHILSHNLDKPQATEQLKIMIHFMRGGFLSLLPDTNNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9L6</accession>
    <name>F7K9L6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 2 lantibiotic biosynthesis protein LanM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40783.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359770.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02384"/>
    <dbReference type="EnsemblBacteria" id="EGN40783">
        <property type="protein sequence ID" value="EGN40783"/>
        <property type="gene ID" value="HMPREF0994_02384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009398_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04792">
        <property type="entry name" value="LanM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017146">
        <property type="entry name" value="Lanti_2_LanM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037228">
        <property type="entry name" value="Lant_mod_RumM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03897">
        <property type="entry name" value="lanti_2_LanM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="122"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40783.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="960" mass="109160" checksum="7F9C826E1ACA4931" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9R8</accession>
    <name>F7K9R8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="6">HAT</shortName>
            <ecNumber evidence="6">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Homoserine transacetylase</fullName>
            <shortName evidence="6">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metAA</name>
        <name evidence="8" type="ORF">HMPREF0994_02599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252500.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02599"/>
    <dbReference type="EnsemblBacteria" id="EGN40582">
        <property type="protein sequence ID" value="EGN40582"/>
        <property type="gene ID" value="HMPREF0994_02599"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2847"/>
    <dbReference type="eggNOG" id="COG1897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057851_0_1_9"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019281">
        <property type="term" value="P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03131">
        <property type="entry name" value="GATase1_HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005697">
        <property type="entry name" value="HST_MetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000450">
        <property type="entry name" value="H_ser_succinyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01001">
        <property type="entry name" value="metA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000450-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="35603" checksum="8002A68872E775C4" modified="2011-09-21" version="1">MPIKVQSDLPARAILEDENIFVMDEYRAQHQDMRPLQICILNLMPVKQDTELQLLRSLSNTPLQVDVTFMKMNSHTSLNTSPTHLNKFYNTFNELKSHKYDGLIITGAPVEQIPFEEVDYWPELCEIMEWSKSHVTSTFHICWGAQAGLYYHFGLNKVLLPEKLFGVFSHKVSNRRVPLVRGFDDYFYIPHSRHTTVPAEEIHACRELLVMAESEEAGVLLAMAGEGRQIFVMGHPEYDRYTLHNEYMRDKEKNLPIQVPLNYYPEDDCTQRPTMLWRSHCNDLYTNWLNYYVYQATPYDLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9V0</accession>
    <name>F7K9V0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wzz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252534.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02633"/>
    <dbReference type="EnsemblBacteria" id="EGN40616">
        <property type="protein sequence ID" value="EGN40616"/>
        <property type="gene ID" value="HMPREF0994_02633"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2888"/>
    <dbReference type="eggNOG" id="COG3944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082668_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="27451" checksum="6827BE6997210EFF" modified="2011-09-21" version="1">MEENTMQQTDEIEIDLWEICLVLVHNLALIVSVGIMTALGTFLITQLFITPKYESTTKIYILNKQENNAVTYSDIQLGTQLTKDYAELIQSRFVLEEVVQGMGLDLSYEEMKKKVSVTTPTDTRILAITVEDTDPVMAMQLANSIREAAAVHIMNVMDIQAVNVSETANMPMKKASPSVMKNTFIGGVLGIFLMIAVILVRFLMDDTIKTPEDVEKYLQLSTLAVIPLNEGEEDGKKKKKKVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9V2</accession>
    <name>F7K9V2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252536.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02635"/>
    <dbReference type="EnsemblBacteria" id="EGN40618">
        <property type="protein sequence ID" value="EGN40618"/>
        <property type="gene ID" value="HMPREF0994_02635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2890"/>
    <dbReference type="eggNOG" id="ENOG5032WQX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033607_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="29006" checksum="55ED566C47BC7BFA" modified="2011-09-21" version="1">MKKLVFIIGGIDIVLLAVCMFLYLGKDRTAPVISFGENAVSYEEGMDESLLLQGVVAMDEKDGDVSDSLLVEKIAGTNGKEVIVTYVARDSANNVGKASRAFPVAGSYTGGDVLSAAGEGLDDEYGMDESRMEESETETESNEESSSVPDDVDRNDAEEERNGGDGEEGRQDEQGEEPQERQEPQAGSNPVLVTSGDVVSTKIGTAPNWGQVIAAMTDDKDDYNTLYNNLKLEGHVDLNAVGEYPVTLYTVDSDGNRSEVRDLVVRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA53</accession>
    <name>F7KA53_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_02739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252640.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02739"/>
    <dbReference type="EnsemblBacteria" id="EGN40722">
        <property type="protein sequence ID" value="EGN40722"/>
        <property type="gene ID" value="HMPREF0994_02739"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2996"/>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_9"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="169" mass="18670" checksum="0EF2937DE66E8A71" modified="2011-09-21" version="1">MRKKVFQLLVDNTSGVLSRISGLFSRRGYNIETITAGVTADPRITRITIVANGDDEILEQIEKQVSKLVDVRDIRELKPEESVYRELALIKVSVSAEKRQDVIAITNIFRANIIDVGQESLIVEITGNQSKVDACINLLSNYEILELARTGIAGLGRGTGNVVYLDPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAL2</accession>
    <name>F7KAL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02838"/>
    <dbReference type="EnsemblBacteria" id="EGN40447">
        <property type="protein sequence ID" value="EGN40447"/>
        <property type="gene ID" value="HMPREF0994_02838"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3106"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="227" mass="24821" checksum="AD7190066C1DF931" modified="2011-09-21" version="1">MKNMTSILNTQELVKHYGSGESVVKAVDHTSLEVRRGEFTAIVGRSGSGKSTLLHLLGGLDRPDSGKVFIEGKDIFSLKDEELAVFRRRKIGFIFQDYNLVPSLNVWENIVLPIGLDGKKADREFVTSVIESIGIADKIKALPGTLSGGQQQRVAIARALASRPAIILADEPTGNLDSRTEMEVISLLKSCVADYCQTLVMITHDETVAQMADRILIIEDGRVVANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAQ1</accession>
    <name>F7KAQ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutL</name>
        <name evidence="8" type="ORF">HMPREF0994_02877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252778.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02877"/>
    <dbReference type="EnsemblBacteria" id="EGN40486">
        <property type="protein sequence ID" value="EGN40486"/>
        <property type="gene ID" value="HMPREF0994_02877"/>
    </dbReference>
    <dbReference type="GeneID" id="29723361"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3146"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="551"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="737" mass="83003" checksum="979495B062AF9E84" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAQ5</accession>
    <name>F7KAQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252782.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02881"/>
    <dbReference type="EnsemblBacteria" id="EGN40490">
        <property type="protein sequence ID" value="EGN40490"/>
        <property type="gene ID" value="HMPREF0994_02881"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3150"/>
    <dbReference type="eggNOG" id="ENOG5032VVW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1701171_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="153" mass="16646" checksum="2B9EACEDEF34EC24" modified="2011-09-21" version="1">MKKQWTVTAADGMNHVIEYKGRSLLVDGQKYPLKSSNWFIQLIDYAINFGETQCRLVVMGNKVDLAVNGRYLGSGEPYQPIASLPVYVSVLAGISCVLGFLMNSWLGLCLGVLIGVMYFNLALKKKNGIIVVAFIIASILQVALGIGVAFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAX1</accession>
    <name>F7KAX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252901.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03000"/>
    <dbReference type="EnsemblBacteria" id="EGN40320">
        <property type="protein sequence ID" value="EGN40320"/>
        <property type="gene ID" value="HMPREF0994_03000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3277"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="15514" checksum="7438D83983A21BB3" modified="2011-09-21" version="1">MIILDYKDARPIYEQVVDKFQKLILTGALEPNTKMPSVRSLAVELSINPNTIQRAYSELEREGFIYTVKGRGNFVAYDESLLRYRKDEIYRKLEEIVREAGEIGISRQELSAYLKERQEKVLHVTSGEDFCYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAX5</accession>
    <name>F7KAX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03004"/>
    <dbReference type="EnsemblBacteria" id="EGN40324">
        <property type="protein sequence ID" value="EGN40324"/>
        <property type="gene ID" value="HMPREF0994_03004"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3217713_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="44" mass="4906" checksum="7559761A4A1F8E7D" modified="2011-09-21" version="1">MLPGVVKAVKRPLEMSLPTGRGMYFHKKTTPELPVVVKCRLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAY9</accession>
    <name>F7KAY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252919.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03018"/>
    <dbReference type="EnsemblBacteria" id="EGN40338">
        <property type="protein sequence ID" value="EGN40338"/>
        <property type="gene ID" value="HMPREF0994_03018"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3297"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="30275" checksum="CF74B5DF21CD143D" modified="2011-09-21" version="1">MKKVLTIAGSDPSGGAGIQADIKTITVHGLYASAVITSLTAQNTTGVYAISNVEPDFIAAQLDCVFSDIFPDAVKIGMVSGEEILEVIIHKLKQYRPGNIVIDPVMVSTSGRELLSSRALKLMEAKLLPMGTLITPNIPEAEILTGLSVKTEEDMKKAAKELALRTGAAVLVKGGHRESDAADILFRDGCYTRFSSPRIDNPNTHGTGCTLSSAAACHLAEGKSPEESIKRAKEYLNGALKAKLDLGKGNGPLNHMYAVKQEGIKEEVKVDKIKECPESGSQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAZ5</accession>
    <name>F7KAZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252925.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03024"/>
    <dbReference type="EnsemblBacteria" id="EGN40201">
        <property type="protein sequence ID" value="EGN40201"/>
        <property type="gene ID" value="HMPREF0994_03024"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3303"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747717_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="44"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="389" mass="44435" checksum="3727BB5178C1D738" modified="2011-09-21" version="1">MLTKITMNNFKSFKNQTTVDLTKTNYTVLPKNVSENGVLKGCMFVGANASGKSNIILSVKLLLDLLFSERSINSGMFKCMFGTGYSYSLVYDFLIDTKKVKYAIEVDTRKVGITEKLYVEDQLLLDRIGVSAKSYIAEKAGNFYDESDVGKDTLFLRTLYFNTKFASNKILVKWMDYLKNSVYINMFDQVIQSYGKTDLSLAQYLDRDGCNEINDFFTEYNFEQKVEYAHSAEGTNYRIIAGDDEKEKSIFFRRKDVDVPIPFVEESMGNQNLLRLLPAFLYVLKKGGMLLIDEFSSGFHNQLESLMVRYFMQKSKNAQMIFVSHSTNLLSNSILRPDQEYTVEFHGNEGSSIHRISSDQPRSAQNVEKMYVSGVFGGIPLYHEVADEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB40</accession>
    <name>F7KB40_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">HMPREF0994_03070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252971.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03070"/>
    <dbReference type="EnsemblBacteria" id="EGN40247">
        <property type="protein sequence ID" value="EGN40247"/>
        <property type="gene ID" value="HMPREF0994_03070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3355"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="26861" checksum="B38D69893A953C41" modified="2011-09-21" version="1">MARKKIIAGNWKMNMTPSQAVELINTLKPLVATEDADVVFCVPAIDIIPAIEAAKGSNIEIGAENMYYEEKGAYTGEIAPDMLTDVGVKYVIIGHSERREYFAESNETVNKKVLKAFEHGITPIVCCGESLTQREQGITIDWIRQQIKIAFLGVTAEQAKTAVIAYEPIWAIGTGKTATTEQAQEVCAAIRVCIGEIYDEATAEAIRIQYGGSVNAGTAAELFAQPDIDGGLVGGAALKPDFGKIVNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBC5</accession>
    <name>F7KBC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253057.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03156"/>
    <dbReference type="EnsemblBacteria" id="EGN39986">
        <property type="protein sequence ID" value="EGN39986"/>
        <property type="gene ID" value="HMPREF0994_03156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363878" evidence="2">
        <location>
            <begin position="26"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="446" mass="48783" checksum="BE2E102BC648D04A" modified="2011-09-21" version="1">MKKIVAALLVGAILLGGTGCGSGGASDTASQSSPQPAAESDSSVQETGEKEGVIELVYWKSYRVNQDAVDKFNADHPNIHVTAEVFPDHASTLQKIQVQASAGSAQMPNVIQLDTCMTATVDSVAPLLDLKPYLDKSDTLKLDNFYDTFQEEAYVGDKVAGLHVCANCDVLFYNKEIFEQAGLDTENPPSTWDEVIAAGKQIKEKCGNDIIPFAYTGITGDYYEQFSWEWQAMVQSAGGALFNDDYTEPLFNSPEGIEALQFLVGSVTDTQIATLNYPEKGFENGKVGMYMDGTWSINTYQEALGENLGTGLMPGKVESKVMVGGDQMMIVDSKDEAVNDAAFEFLTYMMSEEVVIANSKEQGELVCQKPIAETEVYQEYLSASSSMQVAQSAMDHCAYRARVPWYDEWSQAVYAVCEPCLYGEISCEDALAELESQTKDIISKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBE3</accession>
    <name>F7KBE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253078.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03177"/>
    <dbReference type="EnsemblBacteria" id="EGN40007">
        <property type="protein sequence ID" value="EGN40007"/>
        <property type="gene ID" value="HMPREF0994_03177"/>
    </dbReference>
    <dbReference type="GeneID" id="29728865"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3470"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870712_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356783" evidence="1">
        <location>
            <begin position="32"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="318" mass="35002" checksum="F21C4B2060626184" modified="2011-09-21" version="1">MTKRVNRRLFHTALAFAAVCALTVPSMTIRAEKTAEAGEVTQTALAAVQEEAPGTEQPQDTAAVTLTTVPEEDSEGFVLQLQSIRDIQQTQLEQVQTQIRTLTQLQETAVIDAAQLQLLGQLQTLEQVQLEQIAQTDTQLQAFADLMTAEEELAEGPEIIFVGDSRFVQMHNAVGGSDYVWIAKSSQGYKWFASEAVPQIDAVVGRGTKILINLGVNDVANVNAYAELVNKKAAEWTQKGATVYYASVNPVENGQYITKSMVNTFNKKLQARLSPQIHWIDSFSYLQGTGYTLTDGLHYSKGTSKTLYKYYLSALGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBE8</accession>
    <name>F7KBE8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253083.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03182"/>
    <dbReference type="EnsemblBacteria" id="EGN40012">
        <property type="protein sequence ID" value="EGN40012"/>
        <property type="gene ID" value="HMPREF0994_03182"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3475"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="34316" checksum="0CF750BE752C5593" modified="2011-09-21" version="1">MKISRPLRENRQHGDLLFPVSAYETKMEQDFEMPLSYHWHPEIEIFFITSGKANFQVEAEPFIIEEGDVLLIKPNALHGSHDCFGTQLEFRAVVFDYSFLSGMANDRIEQKYLNPLFSEEQGHFILLREKNSIQKALFEMLNKTFFVFDEKEKGYEVLVRAYLLQVVYDILMLQKGEIKPVKTNTRKSEMIRKIVGFVEENHTQRIVLNSLAAYLSVSEGYLCRFFKDNFHMTFVEYVQRVRLQKAERLLRETDDPVGKIALDVGFGSGNYFTTEFGKLYHTTPQKYRKGQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBT6</accession>
    <name>F7KBT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253234.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03333"/>
    <dbReference type="EnsemblBacteria" id="EGN40163">
        <property type="protein sequence ID" value="EGN40163"/>
        <property type="gene ID" value="HMPREF0994_03333"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="14510" checksum="541D33553CC15FFF" modified="2011-09-21" version="1">MKALPQISEAEFQVMKIVWEHAPVSTNQVTEYLTRTTKWSPKTIQTMLKRLVQKKALTYDKEGRVFIYTPLIGHEDYVNQESRHFLQRFYNGNVVSMVTAFLDMEELSQQEVDELKELLTAHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC94</accession>
    <name>F7KC94_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253374.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03473"/>
    <dbReference type="EnsemblBacteria" id="EGN39546">
        <property type="protein sequence ID" value="EGN39546"/>
        <property type="gene ID" value="HMPREF0994_03473"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3798"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054162_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="146"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="342" mass="38053" checksum="2E558FE3E3D32B53" modified="2011-09-21" version="1">MNSLERFYATAERKPVDRPAAWLGMPDPQALPGLFSYYGVKDIHELKMAVGDDFYAVEVPYESETAHAIYAAFDWYKNGEVDAMNRTLTAPGCFHDAEDMEDLVFDWPDPAAYIDAAECRRRVEMAPEGKTVLGILWSAHFQDTCAAFGMETALMNMIAAPELYEAVNEKVLEFYLKANRIFYEATRGKLHAVLIGNDMGSQRGLMISPELVRRFVIPGCRRLTEQAHSYGLKVIYHSCGAISDIIPDLIDAGVDIIHPIQALAAGMEPEGLKEKFGDRVSFCGGVDTQELLVHGTPEDVRKKVEELKRLFPTGLILSPSHEAVLPDVPPENIGALFDAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCC3</accession>
    <name>F7KCC3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SASA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253407.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03506"/>
    <dbReference type="EnsemblBacteria" id="EGN39579">
        <property type="protein sequence ID" value="EGN39579"/>
        <property type="gene ID" value="HMPREF0994_03506"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_581270_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SASA" evidence="2">
        <location>
            <begin position="121"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="480" mass="53161" checksum="67B76CD2935DD064" modified="2011-09-21" version="1">MHGITLTSGPADWEIIQQEKEKATVELAGTYKVHPAAIEVGVASATPVVRVMREDDNTTVIPWTPAVQVTQGENFTGSFRTELVIPAGGLYRIETSLETKSTLPNLTWLYRGDCVLHVGVGNLFLIAGQSNSAGYGKDYCTDPPHLCVHLFRNRNQWDLASHPMNESTAAGSLPNEEMGIPGVSPYLSFGKKYYELTGMPVGLIQTAQGGSSIERWNPKDGDLYGNMMNKIRETKGRYAGVLWYQGCEDTRPEQAEAYGEHFRELAEALRAALGYEIPFFTMQLNRFINGPFDEAWGMVREAQRRAALSIPAVFVLPTTNLSLSDSVHNSAQANVALGIRLARQCACVLNGAEEFEAPTFDGAMIADQEEKARLGIQGTWLRITFAHVKNCFMLYSANGRDSGFTLEDSAGPVEIKSIRANREDKNRVYLELDREPGEAAMLSFAWEADPVKLPMVDEVTYMPPLSFYRINLEQTGGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCD2</accession>
    <name>F7KCD2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253410.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03509"/>
    <dbReference type="EnsemblBacteria" id="EGN39582">
        <property type="protein sequence ID" value="EGN39582"/>
        <property type="gene ID" value="HMPREF0994_03509"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3836"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013148_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="679" mass="77441" checksum="01C3E60A537B72BB" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCF0</accession>
    <name>F7KCF0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253430.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03529"/>
    <dbReference type="EnsemblBacteria" id="EGN39438">
        <property type="protein sequence ID" value="EGN39438"/>
        <property type="gene ID" value="HMPREF0994_03529"/>
    </dbReference>
    <dbReference type="GeneID" id="29728929"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3856"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="35335" checksum="FBE5F9E13BC7CF2C" modified="2011-09-21" version="1">MKNNIKQKGIPTRKGKRQERWLILFSMSLLLLYIGIFNYFPIFYSLTGSFFEWKPIKGIFRFAGFDNYMWMFREPVFWTSLINTLVFALAACFFYVVLGLIFATLIYLSPRFQGFFRTTYFLPVITSGVAVSLLWKYAFYNTNNGVFNVVLEFFGLPSQMWLLDEKQVLGCIILMTVWKEIGYAIIIFIAGLNEIPGELFEAATIDGGSRLQCFRHIIIPRIRPTTLLVAVTGMINFLQVFNQVILMTSTAGKSPGGPGTSSYTLMLLIYEQGFRDFNFGRASAIGYALVLIIMVFTLIQFRLNRTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCJ8</accession>
    <name>F7KCJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253485.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03584"/>
    <dbReference type="EnsemblBacteria" id="EGN39493">
        <property type="protein sequence ID" value="EGN39493"/>
        <property type="gene ID" value="HMPREF0994_03584"/>
    </dbReference>
    <dbReference type="GeneID" id="29728724"/>
    <dbReference type="eggNOG" id="ENOG503314B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106046_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="29305" checksum="4E9C7E1A330C5FE2" modified="2011-09-21" version="1">MGDTKIVYDEKFGITTFKREICAQLGESFWNELVENIELPDIDSECKCQCHNMYQFMKRLEEMTDEETLKKILYKVRHGLHPSQCEWAHNEFMEAGNLDDFLKKHLSDELNGFIELNKEKKDFYGQEITDEVLTFIKENPKMLAPERKGNKLYCMAFPCNMKEYLSVTDEKMKRYYACHCPFAKESILSENVVSSVLCNCSLGHMMNFVEAFMGRELRGKVVHSVLNGDLICEYEIEIPDDIMQKYVTSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCP3</accession>
    <name>F7KCP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253523.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03622"/>
    <dbReference type="EnsemblBacteria" id="EGN39217">
        <property type="protein sequence ID" value="EGN39217"/>
        <property type="gene ID" value="HMPREF0994_03622"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3955"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018331_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="697" mass="79498" checksum="61F4B34A83DE59B6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCV2</accession>
    <name>F7KCV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycyl-radical enzyme activating protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_03681</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253582.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03681"/>
    <dbReference type="EnsemblBacteria" id="EGN38962">
        <property type="protein sequence ID" value="EGN38962"/>
        <property type="gene ID" value="HMPREF0994_03681"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4016"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058969_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040074">
        <property type="entry name" value="BssD/PflA/YjjW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01118">
        <property type="entry name" value="activating_enzymes__group_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN38962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="34151" checksum="5C99B55D588A28A3" modified="2011-09-21" version="1">MELPLITNIQKYAIHDGRGIRTTVFFKGCPLACRWCHNPETQVYGKELIFYEERCTGCGECVKECRNGAVTAADGKAFTDRELCAGCGECVDGCMRNARQLCGRSYTVGELTEELLKDRAFYETSGGGVTLSGGEPLAQDMDYLEKLMGTLCRRGISLNVDTCGAVAFERLERVMPFTDRFLFDLKLLDEDKHREYTGRDNKLILENLKLLSGKGARIWIRIPVIGGVNDEEEELERMAGFLSENVRAEQINLIPYHNTGSGKYGHLNREYQGGMFYAPPKERMQELQRLMERKNIAPVFIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCX5</accession>
    <name>F7KCX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253605.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03704"/>
    <dbReference type="EnsemblBacteria" id="EGN38868">
        <property type="protein sequence ID" value="EGN38868"/>
        <property type="gene ID" value="HMPREF0994_03704"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4043"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="315" mass="35510" checksum="BD0FD581C9FD8C91" modified="2011-09-21" version="1">MKKSKQNAVTLPPRKSIGKQMLKHWEFYVLLLPGIVLTIIFKYVPIYGVQIAFRDYNAVDGFWGSAWVGLKWFERFFNSYNSVRMIRNTVLLSLYSILWTFPIPIILALLINQVKGKKFQRVTQTVIYAPHFISIMILCGMLRIFLSPYGGLINVIAQALGAPEAVNYIDSASAFRTIYISSSIWQDAGWGTIIYLATLSSVDASLHEAAKVDGASTWQRILHIDIPELVPIIVIQLIMQFGNLMNVGFEKAFLLQTNLNKETSEIIATYVYEQGMLKAMYSFSTAVGLFNTAVNIILLIAVNKICKKLSDVSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDA0</accession>
    <name>F7KDA0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253730.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03829"/>
    <dbReference type="EnsemblBacteria" id="EGN38594">
        <property type="protein sequence ID" value="EGN38594"/>
        <property type="gene ID" value="HMPREF0994_03829"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370398_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="651"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="751" mass="85303" checksum="EC8879739DAFB237" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDG6</accession>
    <name>F7KDG6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-L-AF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253804.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03903"/>
    <dbReference type="EnsemblBacteria" id="EGN38668">
        <property type="protein sequence ID" value="EGN38668"/>
        <property type="gene ID" value="HMPREF0994_03903"/>
    </dbReference>
    <dbReference type="GeneID" id="29729482"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4247"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="305"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="509" mass="58569" checksum="8F250A5774A3C8AA" modified="2011-09-21" version="1">MEKGIKQKIIVNPAFTVGKVDERLYGTFLEHIHTIVYGCLYNPSHPQADANGFRKDVLDLLRDLGTTFIRYPGGNFVSGYHWKDGIGPRDKRIRKYDLAWEQEESNQVGIDEFCTLCRQLNIEPMLVLNLGTGTSEEALEELEYCNYDGNTKWAVERRKNGYQNPHNVKLWGLGNEMDGIHQIEHKTPVEYARKAVETARMMKKMDKSIKLVLCGSCSPEIDLKTYPEWDRIVLEEAYEDIDYISLHRYYTYNPDTGMYAMNTDTLENIAHLPIDISNYIDTIMAASRFVQGKKRCSKSVYISFDEWGILSSKNFEKEKYPQWTEICDDKRSSTALDAVLHGAFMITMINKCDVVKVACESIVIGSMIMVDPNGGCFRQTTFYPFRDVALLGKGIVLKQSAEGPREDAGKYGELPVIQSAVIYNDEKKEIVVFAVNFSKQKDIPFELSIQEFKEAECIEFRQLYEKEAFAGNTFKNPFRVVPHLLEVDKKQRNFVLPPISWNVIRYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDI5</accession>
    <name>F7KDI5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253830.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03929"/>
    <dbReference type="EnsemblBacteria" id="EGN38694">
        <property type="protein sequence ID" value="EGN38694"/>
        <property type="gene ID" value="HMPREF0994_03929"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4276"/>
    <dbReference type="eggNOG" id="COG5652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096028_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="188" mass="21657" checksum="7D7B9B1483E0778B" modified="2011-09-21" version="1">MKYVKLFFKKLLRYVLKPLSFLPALIMMYVIFSFSAQDGDVSGAVSSSVSLRFVQACEQVLDKDWNDAQILHYAQRIEHYVRKTAHMTEYFLLAVSVSFPLYVYRLRGWKLLLAAGLFCVAFAGLDEWHQSFVPGRTPSPRDVLIDSIGIFAGIEITRLLCYIGRKTIFRPLSLGNSRTEEEYEEDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDL9</accession>
    <name>F7KDL9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253865.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03964"/>
    <dbReference type="EnsemblBacteria" id="EGN38729">
        <property type="protein sequence ID" value="EGN38729"/>
        <property type="gene ID" value="HMPREF0994_03964"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4316"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="276" mass="29834" checksum="F7FE17C9FF98DF92" modified="2011-09-21" version="1">MSENCSHNCSSCKESCNDRDPKSLLQEPHEMSSIKNVIAVVSGKGGVGKSLVTSLMASSMQKKGYHTAIMDADITGPSIPKAFGMHEKAYANEMGLIPVKTRGGIDIMSINLLLDNDTDPVLWRGPVIAGAVSQFWSEVIWDNVDYMFVDMPPGTGDVPLTVFQSLPLKGIIVVTSPQELVSVIVEKAVKMAEMMNIPVLGIVENMSYYECPDCHSRHSIFGESHIEEVAAKHNISAIAKLPVNPAIAAACDLGEIEALDAPWLSELSSSIEKMCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDU2</accession>
    <name>F7KDU2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04021"/>
    <dbReference type="EnsemblBacteria" id="EGN37710">
        <property type="protein sequence ID" value="EGN37710"/>
        <property type="gene ID" value="HMPREF0994_04021"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175460_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046140">
        <property type="entry name" value="DUF6142"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19639">
        <property type="entry name" value="DUF6142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="105" mass="11483" checksum="9A03B7E3BC30E407" modified="2011-09-21" version="1">MGRKYIFTNKKESRKGIMSTVLGAVSLFSLFLAVYGTFQNQGEALVKYGMGVLFALLFALTGIVLGIMSKMEEDKFYLFSYLGILLNVLAIAGVGFILYAGVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE99</accession>
    <name>F7KE99_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04178"/>
    <dbReference type="EnsemblBacteria" id="EGN36458">
        <property type="protein sequence ID" value="EGN36458"/>
        <property type="gene ID" value="HMPREF0994_04178"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4558"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006515_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="178"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN36458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="796" mass="93139" checksum="AB5A514ECBEF1E13" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEA3</accession>
    <name>F7KEA3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254083.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04182"/>
    <dbReference type="EnsemblBacteria" id="EGN36462">
        <property type="protein sequence ID" value="EGN36462"/>
        <property type="gene ID" value="HMPREF0994_04182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="PTHR10363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="438" mass="50671" checksum="07EE1B9DE912B5B3" modified="2011-09-21" version="1">MQEISQNNIKSYQNTYLSHSENRKLQQEYHEKSISEIAFQASKALQHPFIFSVDLPTMSAVSQGATGRCWIIAGLNLLREEAVKKMNREKLPNGEFTFSAAYLCFWDKLEKSNCFLERAIELRNEPYDIRTVNSWFQYAVTDGGFWTYFTDLVKKYGVVPADAMPETIHSCNTEEMNSRLNCYIRKISADIRNAAKAGKDTDDIYAIKEQAMHRIYSFLCLCYGYPPESFTFDFICGKEKKEYTPSELYQELLEGFPDNFVSVISLPYENLPFGKPCRLDDVFQVAGMHDEVFFNLPIEDLKACCKQQLKSGIPVFCMADDDKMCVDELQLWDDKCFDYDRITGFSSDMSRKDYFQLKAGMAGHSMLITGVDIARDGQPVQWKFENSYDTEGLHKGYFTCSDSWFERYMVGAVIHKDFLKQYDLTGTAEHTFRIWDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEK6</accession>
    <name>F7KEK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN36097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254186.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04285"/>
    <dbReference type="EnsemblBacteria" id="EGN36097">
        <property type="protein sequence ID" value="EGN36097"/>
        <property type="gene ID" value="HMPREF0994_04285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4679"/>
    <dbReference type="eggNOG" id="COG3254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100689_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019299">
        <property type="term" value="P:rhamnose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01663">
        <property type="entry name" value="L_rham_rotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013448">
        <property type="entry name" value="L-rhamnose_mutarotase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02625">
        <property type="entry name" value="YiiL_rotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN36097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="103" mass="12253" checksum="0273C89A0CEA72EE" modified="2011-09-21" version="1">MIKGFKMKLFEGQEAEYERRHNLLWPEMKDMIHEHGGKNYTIFLDRETLTLFGCIEIEDEELWAKGADTAINRKWWDYMADIMETNPDNSPVSIDLQTVFHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF02</accession>
    <name>F7KF02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254340.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04439"/>
    <dbReference type="EnsemblBacteria" id="EGN35749">
        <property type="protein sequence ID" value="EGN35749"/>
        <property type="gene ID" value="HMPREF0994_04439"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4848"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="322"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="447"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="720" mass="83598" checksum="4A7422A788579476" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF54</accession>
    <name>F7KF54_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254397.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04496"/>
    <dbReference type="EnsemblBacteria" id="EGN35806">
        <property type="protein sequence ID" value="EGN35806"/>
        <property type="gene ID" value="HMPREF0994_04496"/>
    </dbReference>
    <dbReference type="GeneID" id="29726547"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="155" mass="17598" checksum="66EE52D73A853AE9" modified="2011-09-21" version="1">MQKTFRKRIITQIGILTEDIRTAKTAWEKFLGLPSQQISQSDGYAQTHAVYRGEPLEGRIYQVCFNFENIELELIQPVGDVPSYWKECLEKNGPGIHHISFAVKNMDKCIADCEELGIPSIQRGDFPGGRYAYLDASDSMNVVLELLEKEQEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF82</accession>
    <name>F7KF82_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254430.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04529"/>
    <dbReference type="EnsemblBacteria" id="EGN35839">
        <property type="protein sequence ID" value="EGN35839"/>
        <property type="gene ID" value="HMPREF0994_04529"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4945"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_0_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="194" mass="22060" checksum="A626F4E324895908" modified="2011-09-21" version="1">MKSKGKDYRTRVTKMLIRKAFTDMLKEKPIQSITIKELCETAGINRGTFYSHYSDIYDLLEKMEEEMMADFIKALEPLLETDKEDLTPVKITTGIFRCLKENADICTVTLGDYGDKDFALRLINLGREKCVETYSRYFGSATPKQIEFFYAFVSAGCIGLLQKWLAEGMVSSPEEIAAMAENIMMYGMGALERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFC9</accession>
    <name>F7KFC9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04558"/>
    <dbReference type="EnsemblBacteria" id="EGN35327">
        <property type="protein sequence ID" value="EGN35327"/>
        <property type="gene ID" value="HMPREF0994_04558"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080433_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="30764" checksum="628DE4721AFDF3E5" modified="2011-09-21" version="1">MYSIEIERPTTKELFEAAAGYGFTKMQFDFSSVCDEQMPETIERSLLQEIREAADRTGIEIVAVNGTFNMIHPDKQVRLDGLKRLETIARSCKTLGCSIITLCTGSRNVENMWSRHEDNDKPQAMEDLMGTMGKALEIARKYDLVLGIECEPSNCIDSAEKAERMFEAFGRDEHLGIILDAANLFRAGMARKENVRSVITDAFDRLGNCICLAHGKDISEGEDIHYTYAGDGIVDFPFFLEKLKEADYNGCMILHGIKDEKDMEKAVAFMKGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFI2</accession>
    <name>F7KFI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea ABC transporter, urea binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04611"/>
    <dbReference type="EnsemblBacteria" id="EGN35058">
        <property type="protein sequence ID" value="EGN35058"/>
        <property type="gene ID" value="HMPREF0994_04611"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5034"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356587" evidence="1">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="438" mass="46676" checksum="7429EAE70C54EB88" modified="2011-09-21" version="1">MKRRAIGTFGAWITAAALCLSLTACGGAMSEVTEGAAAPDTAGSQAEADSASAAGGQETAAVSGEDSIKVGILHSLSGTMAISETSVRDAELLAIKEINENGGVLGKQLVPVIEDGASDNAVFKEKAEKLLLNDKVATVFGCWTSASRKAVLPAFESSNGLLWYPVQYEGQESSPNIFYIGAAPNQQIVPAIEYMNENYGKKVFLLGSDYVFPRTANAIVKKQAEALGMEIVGEEYTPMGHTDYTTILSKIKEADPDFIFNTLNGDSNVAFFKQFKDAGLTPEQIQTCSVSIAEEEVKGIGASYLEGHLVAWNYYQTTATPENEKFVEAYKAEYGADRVTDDPIEAGYNAVYLWAAAVEKAGTTDVDAVKEAAAGISLDAPEGKITIDGENQHIYKPVRIGMVNADGLIDEVWSTPEPVKPDPYLKGYEWAAGLSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFL1</accession>
    <name>F7KFL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254541.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04640"/>
    <dbReference type="EnsemblBacteria" id="EGN35087">
        <property type="protein sequence ID" value="EGN35087"/>
        <property type="gene ID" value="HMPREF0994_04640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5068"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="315" mass="34036" checksum="5B8FC23C80F56CB7" modified="2011-09-21" version="1">MSKYIIKRILIAIPVLIGITIIDYAIMCLAGSPLEMLQGPRISEAAVEAKRIALGLDQPFYVQYFVWLGQLLHGNMGYSLKSYQSVSSMIGSHLGPTLLLMGASLIVSLIMAVPAGIYSAIHQYSKGDYTVVTLSFLGSSIPGFFLSLLLIFLFTVKLGWLPSSGMNTLGASGGALDVAKHMVMPVLVLATSMAGTNIRYIRSAVLEILQQDYLRTAKAKGIGRFKVINKHALRNALIPIVTVIGMEIPMLFGGQVIIEQVFSWPGLGLMTMSAITNRDYPVIMGVCLLSAVVVLAANLLTDILYALVDPTIQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFW6</accession>
    <name>F7KFW6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04745"/>
    <dbReference type="EnsemblBacteria" id="EGN34671">
        <property type="protein sequence ID" value="EGN34671"/>
        <property type="gene ID" value="HMPREF0994_04745"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3081028_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="52" mass="5897" checksum="29AC748A62FCF0F7" modified="2011-09-21" version="1">MISAVSVKDRLKNLAKEDGRTMQDELVTYGLEQAIYQSFSGEDVYPTLEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG59</accession>
    <name>F7KG59_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254740.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04839"/>
    <dbReference type="EnsemblBacteria" id="EGN34466">
        <property type="protein sequence ID" value="EGN34466"/>
        <property type="gene ID" value="HMPREF0994_04839"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5282"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="34406" checksum="1AF031CFD5DDDDC7" modified="2011-09-21" version="1">MKIDRLYAITVYLLNHGKTSASGLAGKFEVSVRTIQRDIDALCRAGIPIVAETGASGGYYLSETYHMDRHTATQEDYSFILTALKGFSSAMGNPQIDATLEKVSSLTRNQDDSIILDFSVLREGDEILLKTLRTAIRDKHPVSFTYTNSENVTRIHTVEPIAVIYRWYAWYLLAYSTVKKDYRTYKLIRMSDAVISDMPFTAQHASPEEILRESDRKSPQPSTEVIVRCKSEAKSRAIEYLNGKILRTYENGDCEMLLEVMEKEHFWFGTLLSLGSGVEILAPEHIRVRVLDAAKEIVSLYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGJ8</accession>
    <name>F7KGJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254878.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04977"/>
    <dbReference type="EnsemblBacteria" id="EGN33772">
        <property type="protein sequence ID" value="EGN33772"/>
        <property type="gene ID" value="HMPREF0994_04977"/>
    </dbReference>
    <dbReference type="GeneID" id="29726640"/>
    <dbReference type="eggNOG" id="ENOG50322I5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136896_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="244" mass="27820" checksum="EF62FD66C1765EBD" modified="2011-09-21" version="1">MNKKYIKLIAIDIAIAIIVVILYSPGLIALRVTDESIFRAGMSILAGLGLICIFFSVNIRMLRDPKPILIAPDEVYDLDEARKILRSHMESRMFGSIAKTASGQLDRVQKCRNRINEIIGRKFTEGSMSWDKFQSIVANAEESAIKNVVAMSGRMSIFDEEEYERLKHYKEDDIPDDIQEEQLKLYRDNYESTKAALALNEKILLKLDALAVGLSSFEINANEDMNNEILEEIEKLTNDAKYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH17</accession>
    <name>F7KH17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">HMPREF0994_05153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255054.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05153"/>
    <dbReference type="EnsemblBacteria" id="EGN33186">
        <property type="protein sequence ID" value="EGN33186"/>
        <property type="gene ID" value="HMPREF0994_05153"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5632"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="244" mass="27812" checksum="51218F5B0A8DBC38" modified="2011-09-21" version="1">MSDYNLVQFRKDLEQLPVILNQEQEEKFILYYELLVQWNEVMNLTAITEFNEVLKKHFIDSLSLIRAVPELEEKKLSLIDVGTGAGFPGIPLKIAYPGLKVTLLDSLNKRIKFLNEVIDKLGLEDIEAVHGRAEDYAKPSLFREKYDICVSRAVANLSTLSEYCLPFVRVGGQFISYKSEKIEEEAAAAEKAIHILGGDVKDKKDFYLPDSDIYRILYVIEKKSVTPKKYPRKAGLPAKEPIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHB4</accession>
    <name>F7KHB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255107.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05253"/>
    <dbReference type="EnsemblBacteria" id="EGN33286">
        <property type="protein sequence ID" value="EGN33286"/>
        <property type="gene ID" value="HMPREF0994_05253"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5739"/>
    <dbReference type="eggNOG" id="ENOG502Z9DK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1786069_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031344">
        <property type="entry name" value="DUF5104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17117">
        <property type="entry name" value="DUF5104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363774" evidence="1">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="169" mass="19387" checksum="41FC50339D12FF64" modified="2011-09-21" version="1">MKKVLLLSSVIIILGLTGCSNKYFNDWFSSEQNETDKMCQQIIEACKQQDSEKLKSLFSEESKKNIENLDTEISDFFDYIEGSIQSFEGDCASSSESNYGKRKTELDGMYLILTEKERYCMNFYMYSEDDENAQNVGIYKIEIALESEVAEDNFIWDNPPNGIFVGGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHG3</accession>
    <name>F7KHG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_05292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255135.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05292"/>
    <dbReference type="EnsemblBacteria" id="EGN33027">
        <property type="protein sequence ID" value="EGN33027"/>
        <property type="gene ID" value="HMPREF0994_05292"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5778"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="7"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="397"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="11">
        <location>
            <begin position="633"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="683" mass="77364" checksum="30CB4EA55B7BA072" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHI9</accession>
    <name>F7KHI9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IU_nuc_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255161.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05318"/>
    <dbReference type="EnsemblBacteria" id="EGN33053">
        <property type="protein sequence ID" value="EGN33053"/>
        <property type="gene ID" value="HMPREF0994_05318"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5809"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078738_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="34579" checksum="3B5080BD2FC2BFE0" modified="2011-09-21" version="1">MNNDLGLLNRLNKPAGPVDVVLDTDTYNEIDDQYALSYLVKSGDKLHLKAVYAAPFFNEKSTGPEDGMEKSYQEILHILTLLEKEEYKERVYKGSAGYLPDEQTPVESAAARHLTELAMEYTPEKPLYVVAIGAITNVASALLMRPEIKERMVLVWLGGNSLEWPDNKEFNLFQDVAAARVVFGCGVALVQLPCMGVVSSFTTGAGELEMFLRGKNKLCDYLVDYTEKEGALGSKNSCWTRVIWDVTAVAWLLDESFMEDKLIPSPIPQYDHHYSFDPTRHFIRYVYHINRDNLFEDLFRKLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHY8</accession>
    <name>F7KHY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571063.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05484"/>
    <dbReference type="EnsemblBacteria" id="EGN32925">
        <property type="protein sequence ID" value="EGN32925"/>
        <property type="gene ID" value="HMPREF0994_05484"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032UW5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2648092_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="76" mass="8480" checksum="C0D7BFA87CF195DB" modified="2011-09-21" version="1">MEKLITRKEAAEILGISIATLDAARNNGLISYVQYVQNGCVYFTAAGLQEYIAKCTHRAKPVERSTTYRKPRSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI49</accession>
    <name>F7KI49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_05491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571056.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05491"/>
    <dbReference type="EnsemblBacteria" id="EGN32932">
        <property type="protein sequence ID" value="EGN32932"/>
        <property type="gene ID" value="HMPREF0994_05491"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6005"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN32932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="581" mass="64828" checksum="C57EC08665B87C69" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIA6</accession>
    <name>F7KIA6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05585"/>
    <dbReference type="EnsemblBacteria" id="EGN32410">
        <property type="protein sequence ID" value="EGN32410"/>
        <property type="gene ID" value="HMPREF0994_05585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6102"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="371"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="584" mass="67686" checksum="0E5FB2F9AFCBD199" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIH3</accession>
    <name>F7KIH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255459.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05652"/>
    <dbReference type="EnsemblBacteria" id="EGN32276">
        <property type="protein sequence ID" value="EGN32276"/>
        <property type="gene ID" value="HMPREF0994_05652"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6177"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="224"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="367"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="621" mass="72394" checksum="7A1934101D3D1753" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KII7</accession>
    <name>F7KII7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclophil_like2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05666"/>
    <dbReference type="EnsemblBacteria" id="EGN32290">
        <property type="protein sequence ID" value="EGN32290"/>
        <property type="gene ID" value="HMPREF0994_05666"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6191"/>
    <dbReference type="eggNOG" id="COG4925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1293014_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041183">
        <property type="entry name" value="Cyclophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18050">
        <property type="entry name" value="Cyclophil_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357474" description="Cyclophil_like2 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclophil_like2" evidence="3">
        <location>
            <begin position="103"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="22592" checksum="34EF27EE6FAA8066" modified="2011-09-21" version="1">MRKVITVVCAFLLFLSASSTSSPVGSGAADLGANEAPAADESLVPDETRSTAAESAKPSGTEAAGGRRESDGGENLSAMETTELKESRNREETEIRNTDRVNVQIGNENFTLILYDNDAAAAFADLLPLTLDMSELNGNEKYFYLDSGLPAMAEPVGDIQNGDFMLYGANCLVLFYDSFSTGYSYTRLGRVENPEGLSAALGSGGAVISFQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJN6</accession>
    <name>F7KJN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255848.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06072"/>
    <dbReference type="EnsemblBacteria" id="EGN31426">
        <property type="protein sequence ID" value="EGN31426"/>
        <property type="gene ID" value="HMPREF0994_06072"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6651"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="4">
        <location>
            <begin position="70"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="3">
        <location>
            <begin position="308"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="572" mass="65339" checksum="D9055773AF88BF14" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK25</accession>
    <name>F7KK25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255995.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06219"/>
    <dbReference type="EnsemblBacteria" id="EGN30712">
        <property type="protein sequence ID" value="EGN30712"/>
        <property type="gene ID" value="HMPREF0994_06219"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6812"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="129" mass="14992" checksum="300E1D3967C599C3" modified="2011-09-21" version="1">MEPIQLMSDSEKEIMEIIWDNGGRIYISELLEAVAEAGREWKRTTVRTFLTRLMEKGLLLGVRQGKNCEYRAAITKEEYLSGQARNFVEEVFDGNVKDLLASLIGPEKLETEEIEQLQSFWEKCREDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK66</accession>
    <name>F7KK66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256021.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06245"/>
    <dbReference type="EnsemblBacteria" id="EGN30514">
        <property type="protein sequence ID" value="EGN30514"/>
        <property type="gene ID" value="HMPREF0994_06245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6843"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN30514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="351" mass="36901" checksum="3E2D9BA1E2277F1D" modified="2011-09-21" version="1">MNSAKLQSANKQPKTVYQQNQIKSICFLVLMAVILVLTSLLALRAGSYATPLNELIKGIFGLSGDDKINLVVRNNRLPRICTAIIAGAGLGLAGCILQAILRNPLASASTLGVSQGASFGAAVAIVVFGMGNTMGLGVPVCAFVGSILVALTILGLSRFRNISPEGIVLSGVAISAMFTGATTLIQYFADEVQLATLVYWTFGNLGSTGWDDLGGMGIVVAGLIVYCCFHRWDYNALLSGSETAVSLGINVRRLILVNMVLCCLTTSVIVANVGLISFIGLVAPHIVRMVVGNNHIYVIPGSILTGATILLLSDLFARVVISPVILPIGAITSFLGGPLFLYLLFKEGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK73</accession>
    <name>F7KK73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06252"/>
    <dbReference type="EnsemblBacteria" id="EGN30521">
        <property type="protein sequence ID" value="EGN30521"/>
        <property type="gene ID" value="HMPREF0994_06252"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6850"/>
    <dbReference type="eggNOG" id="ENOG502ZB9V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095712_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="236" mass="25192" checksum="A8C2035EFFACA3C7" modified="2011-09-21" version="1">MDEKKIERIQEDEALKQAFLDDFNKGIHRIGRCMLIVSVILLIGVPFLIGAVNGVTPSLKGFLIGFAKVGIIYIPVAIVEFLVYTPMLGAGGSYLAFITGNVTNMKIPCAMNARDIAKTKVGTPENEIISTISVATSAIVTTLVIVAGVILMIPLRPVLENPVLIPAFDNVVPALFGALGLKYFMKSPKIAAVPVLSMTLLCVFVPAAISQTSLLMIPAGGMALLIGYFLFKKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK78</accession>
    <name>F7KK78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_06257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30526.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360031.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06257"/>
    <dbReference type="EnsemblBacteria" id="EGN30526">
        <property type="protein sequence ID" value="EGN30526"/>
        <property type="gene ID" value="HMPREF0994_06257"/>
    </dbReference>
    <dbReference type="GeneID" id="29724070"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="147"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="358"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN30526.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="615" mass="69953" checksum="458159E90069CBCF" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKC4</accession>
    <name>F7KKC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256073.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06303"/>
    <dbReference type="EnsemblBacteria" id="EGN30222">
        <property type="protein sequence ID" value="EGN30222"/>
        <property type="gene ID" value="HMPREF0994_06303"/>
    </dbReference>
    <dbReference type="GeneID" id="29726943"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6907"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357000" evidence="2">
        <location>
            <begin position="30"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="472" mass="51647" checksum="0B2D317ECAD3D14B" modified="2011-09-21" version="1">MLKKKGTKITALMLAAMMAASAFLSGCGGADSGSSQTGANAQSGNTESAKENAGSDTGSAGKTKITMITYLGNPTRDALIQEMVAGLDNIELEIISPPADQATQKISTMLQAGEDIDIIELDSVPVDHISNGFIEPLNSYVENWEDWGSVSEFLKDQVTSYDGNIYSIPYGVYERALFYRKDWFEDKNIAVPKTWDDLYNAAVELTDPTQNRYGYSFRGGAGTVGFMQMTLLSFADPAKLDIGVPFIANDCKSIYDQPEAIDALNFYKKLYEDGSHPDSIAWGYPEMVEAFYSGVTAMLIQDPEVVATCEEYMEEGTWDVAPLPVGPSGQALFPAGFAGWGIAANSKNKDAAWEVIKTLSSVEGNTTFCKKNGNIPIHTTAQEDPFFSEGYYKCYMDMAADPDSYVGYVDYGERRFASKEELEQISQFGAAADSLVQEMLLGKISPEDCAAKLGAFYSWSQDSEWVKERFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKS3</accession>
    <name>F7KKS3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">birA</name>
        <name evidence="4" type="ORF">HMPREF0994_06452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256214.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06452"/>
    <dbReference type="EnsemblBacteria" id="EGN47587">
        <property type="protein sequence ID" value="EGN47587"/>
        <property type="gene ID" value="HMPREF0994_06452"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7064"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="80"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="2">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN47587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="37672" checksum="1E7BE58E07427290" modified="2011-09-21" version="1">MKSEILSLLRESMLREKAADAPTGREYISGQELCSRFGVSRTAVWKVINQLKEEGYEIEAVQNKGYRLKASPDVIGEIELGSRLQTRGEGHWAGNSLIFYPSTGSTNIDAKRAAEDGAPEGTLVVTDCQNTGRGRRGRDWSSPQGCNLYFTLLLRPDCNPDQACMLTLVMALAVAEAVNELGLEAGIKWPNDIVLSGKKICGILTEMSAEPDYIHYVVIGCGINVNQEEFPSEISRTATSLRLEKGEKISRSALLVSVMDHFEEAYGAFRKTWDLTELLPSYHRFLLNKDARVRVLDPKGEFDGIARGINEKGELLVETEQNGIVNVYAGEVSVRGVYGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKT7</accession>
    <name>F7KKT7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">HMPREF0994_06466</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256228.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06466"/>
    <dbReference type="EnsemblBacteria" id="EGN47601">
        <property type="protein sequence ID" value="EGN47601"/>
        <property type="gene ID" value="HMPREF0994_06466"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7079"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="133"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="252"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGN47601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="44397" checksum="F3C9CA70EAFA57A1" modified="2011-09-21" version="1">MEKHLFTSESVTEGHPDKMCDAISDAVLDALMEQDPMSRVACETCTTTGLVLVMGEITTNAYVDIQKIVRDTVREIGYTKSEYGFDANTCGVMVALDEQSADIALGVDKALEAKEEEKVSAEHKMTEAQLDAIGAGDQGMMFGFATNETEEYMPYAISLAHKLVRQLTKVRKDGTLPYLRPDGKSQVTVEYDENEKPVRLEAVVLSTQHDADVTQEQIHEDIKKYVFDPILPAEMIDDETKFFINPTGRFVIGGPNGDSGLTGRKIIVDTYGGYARHGGGAFSGKDCTKVDRSAAYAARYVAKNIVAAGLADKCEIQLSYAIGVAHPTSIMVDTYGTGRLSDEKLVEIIRDNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDLDLPWEKLDKADALRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKU7</accession>
    <name>F7KKU7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256238.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06476"/>
    <dbReference type="EnsemblBacteria" id="EGN47611">
        <property type="protein sequence ID" value="EGN47611"/>
        <property type="gene ID" value="HMPREF0994_06476"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="3">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="186" mass="20325" checksum="DEDAFC11C1264FA2" modified="2011-09-21" version="1">MTEKEKSHAEMLYQPGDPELAADRDVTVKKLHDYNNIHPLDREARQAAIRELLGHVGENCVVEQPLFCTYGYNTSVGDNFFLNVNGRLMDSGKITIGNNVFIAPGVSIITEEHAMDVKQRIEGLEYTHPVTIGDNVWICTGVIVLPGVTIGDNSVIGAGSVVSKDIPPNCLAVGNPCKVIRRINND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKV5</accession>
    <name>F7KKV5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256246.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06484"/>
    <dbReference type="EnsemblBacteria" id="EGN47495">
        <property type="protein sequence ID" value="EGN47495"/>
        <property type="gene ID" value="HMPREF0994_06484"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7100"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110721_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="177" mass="20109" checksum="38DC913E27286A0B" modified="2011-09-21" version="1">MDRNVLLLKEMIRYYARDPKRIQHFIKVHDFAGMIGKLEGLEDDEQNILEIAAIVHDIGIKVSEEKYGDCSGKHQELEGPVIARTMLEPLGFEDSVIDRVCYLVAHHHTYQDINGLDYQILVEADFLVNLYEDNASREAAEHALQRIFRTESGKSICRDMFGLTEGTADQAGTISIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKV7</accession>
    <name>F7KKV7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256248.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06486"/>
    <dbReference type="EnsemblBacteria" id="EGN47497">
        <property type="protein sequence ID" value="EGN47497"/>
        <property type="gene ID" value="HMPREF0994_06486"/>
    </dbReference>
    <dbReference type="GeneID" id="29729797"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_10_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="36"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="32183" checksum="1A6F3538E1068C77" modified="2011-09-21" version="1">MKALLVLIIILLLLFLLYMVLIMPRFRKPDCKALLHHYYAHRGLHDLSAGIPENSMKAFQRAIDKGFGMEMDVQLSSDGYPVVFHDSTLTRMCGVDKRVNELTLRELKELILADTQEQIPTFQEFLDLVRGQVPLIIEIKMDKRDDRIPEAVNRLLKDYKGVYCIESFHPSALIWYKKNRPDVFRGQLCTNFNKENKNCSLPFFLLGKMLSNIAARPDFIAYNWVYRNDLSRKICCNFYHALPVGWTIRSQEEMDMCRKDFKLFIFENFIPKGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKZ3</accession>
    <name>F7KKZ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256284.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06522"/>
    <dbReference type="EnsemblBacteria" id="EGN47241">
        <property type="protein sequence ID" value="EGN47241"/>
        <property type="gene ID" value="HMPREF0994_06522"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7144"/>
    <dbReference type="eggNOG" id="COG3862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148086_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN47241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="119" mass="12683" checksum="B04D7732083A86BC" modified="2011-09-21" version="1">MEQRELICINCPLGCALTVTLEDKDVVKVTGNTCPRGEAYARKECTNPTRIVTSTVRVKGGHLPVVSVKTASDIPKGKIGECVKALRDICVEAPVHIGDIILENAADTGVNIIATKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL64</accession>
    <name>F7KL64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06597"/>
    <dbReference type="EnsemblBacteria" id="EGN47316">
        <property type="protein sequence ID" value="EGN47316"/>
        <property type="gene ID" value="HMPREF0994_06597"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7221"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="321" mass="36450" checksum="D76E8CF286EEAE90" modified="2011-09-21" version="1">MAKSAQEKADLKAEKIYEKKHRKKYRARPGDILFNMINYLVFTLFTVACIFPFYYLFINTISDNDLVVKGVINFIPRGLHLDNYKSLLNVSDLSNAFLVSLGRTIIGTAFMVAASAFVGYLVTKQEMWGRKFWYRFLIITMYFNAGLIPWFLNMQMLGLTNTFWAYIIPGIVAPYNIILVKTYIESIPAELEESAQIDGATHMMIFRKIIWPLSKPILATIAIFGAVGHWNSFTDSLILMQSAPNLYTLQHRLYIYLNTASNLSALMESGGQISDTVLKSALSAKVIKYTISMVTVIPILVVYPFMQRYFEKGIMLGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLB8</accession>
    <name>F7KLB8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_06647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256400.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06647"/>
    <dbReference type="EnsemblBacteria" id="EGN46571">
        <property type="protein sequence ID" value="EGN46571"/>
        <property type="gene ID" value="HMPREF0994_06647"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7268"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN46571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="230" mass="26160" checksum="EA787CED5065EDDF" modified="2011-09-21" version="1">MTNILVCDDDKEIVEAIEIYLAQEGYHVIKAYDGEQAIRALKTNEVHLLIIDVMMPRLDGIHATLKIREYSSIPIIILSAKSEDADKILGLNIGADDYVTKPFNPLELVARVKSHLRRYTQLGNLNSENNAIFRAGGLVINDETKEVTVDDEPVKLTPIEYNILLLLVKNQGRVFSIDQIYESIWEEEAIGADNTVAVHIRHIREKIEINPKEPRYLKVVWGVGYKIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLD4</accession>
    <name>F7KLD4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">khpA</name>
        <name evidence="3" type="ORF">HMPREF0994_06663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256416.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06663"/>
    <dbReference type="EnsemblBacteria" id="EGN46587">
        <property type="protein sequence ID" value="EGN46587"/>
        <property type="gene ID" value="HMPREF0994_06663"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7286"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="75" mass="8056" checksum="59155F9E2C0AD0E0" modified="2011-09-21" version="1">MKELVEVIAKALVDNPEEVVVTEKEDGKITTIELHVAPSDMGKVIGKQGRIAKAIRAVVKAAALGDKKHVDVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLG6</accession>
    <name>F7KLG6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256453.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06700"/>
    <dbReference type="EnsemblBacteria" id="EGN46624">
        <property type="protein sequence ID" value="EGN46624"/>
        <property type="gene ID" value="HMPREF0994_06700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7327"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="191" mass="21049" checksum="1B693CAD6032F81F" modified="2011-09-21" version="1">MILLIDNYDSFSYNLYQLIGTVNPDIKVIRNDEMTVDAVELLQPELIVLSPGPGKPSEAGICEEVVHRLAGKIPIFGVCLGHQAICEAFGARIGYAKELMHGKTSDALLEPESRLFQGMGEHMQVARYHSLAADPDSMPEELVITARTADGEIMAVEHREYPVYGVQFHPESVLTPEGMDIIRNLLSEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLL9</accession>
    <name>F7KLL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256465.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06712"/>
    <dbReference type="EnsemblBacteria" id="EGN46636">
        <property type="protein sequence ID" value="EGN46636"/>
        <property type="gene ID" value="HMPREF0994_06712"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HJ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152426_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="99" mass="11575" checksum="F81D2E884328B96E" modified="2011-09-21" version="1">MTDSEKLDLLLKQMGAMDERFTQLDNRLMKLENGVTDIRLTLENETGPNIRRVAEGHLDLSRKLDEALKVENEKEMLIIRVNTLENEMRRMKDKINSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLM5</accession>
    <name>F7KLM5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256507.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06754"/>
    <dbReference type="EnsemblBacteria" id="EGN46346">
        <property type="protein sequence ID" value="EGN46346"/>
        <property type="gene ID" value="HMPREF0994_06754"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7380"/>
    <dbReference type="eggNOG" id="COG4833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028686_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014512">
        <property type="entry name" value="O_gly_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021505">
        <property type="entry name" value="O_gly_hdrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="339" mass="39773" checksum="B6AF4D9A19306D45" modified="2011-09-21" version="1">MKKIEEVCERAQYALWNRFWDNEKEVFVNHYPVKEEESWIYWWHAHALDALLDGFVRTKENYYLERFEAEYEGAFRENGGTFLHNWYDDMEWMTLALIRAFDITGEKRYIEQAVYIWNDIKTAWNDSCGGGMAWKKDQLDYKNTPANAPAAIIAFRLYQRLHREEDREWGEKILKWNLDHLMDPDTCFIWDGMNRLGDGKVDYEWKFTYCQGVVIGAAMEYARITNNKEYLDLAGKVARRAVTELADADGIFPYEGPDDCGLFRGIYFRYVYELTQESSEYEDLKEIIKKNARMIAENGMNKDGLVGGDWRQKSEGTIDLAQHLSAVMTLEMAAKLGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLP3</accession>
    <name>F7KLP3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">HMPREF0994_06772</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256525.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06772"/>
    <dbReference type="EnsemblBacteria" id="EGN46364">
        <property type="protein sequence ID" value="EGN46364"/>
        <property type="gene ID" value="HMPREF0994_06772"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7398"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="188"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN46364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="362" mass="39966" checksum="A6067BA8FCCC6CEF" modified="2011-09-21" version="1">MSKKIVLTGGGTAGHITPNIALLPRLLQLGYEISYIGSYNGMEKKLIEDYDIPYYGISTGKFRRYFDLKNFTDPFRVLKGYGEARKILKEICPDIVFSKGGFVTVPVVRAASSLKIPCVIHESDMTPGLANKLCIPVCTKVCCNFPETLRCLPTEKAVLTGSPIREELSRGNKLAALELCHFTANKPVLMVIGGSLGAASINQAVREALPKLLNDFQVVHLCGQEKIDNLLLNQSGYTQFEYLKSELKDVFAMADVVVSRAGANAICELLALKKPNLLIPLSAGSSRGDQILNARSFEAQGFSMVIDEDYLSPDLLIEKVQELYFNRQTYIDAMGKSQQMNATKTITELLDGIAEEHMNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLR5</accession>
    <name>F7KLR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_06794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06794"/>
    <dbReference type="EnsemblBacteria" id="EGN46386">
        <property type="protein sequence ID" value="EGN46386"/>
        <property type="gene ID" value="HMPREF0994_06794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496779_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364162" evidence="6">
        <location>
            <begin position="40"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="336"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="8">
        <location>
            <begin position="424"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN46386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="552" mass="61564" checksum="07F19B4B94E48A3D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLV1</accession>
    <name>F7KLV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000022">
        <property type="protein sequence ID" value="EGN46059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256571.1">
        <property type="nucleotide sequence ID" value="NZ_KE150410.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06830"/>
    <dbReference type="EnsemblBacteria" id="EGN46059">
        <property type="protein sequence ID" value="EGN46059"/>
        <property type="gene ID" value="HMPREF0994_06830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7463"/>
    <dbReference type="eggNOG" id="ENOG502Z84T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1538015_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="174" mass="19675" checksum="F1651BFAFAF301DC" modified="2011-09-21" version="1">MKKRFLKIVIGIVLVCILFVGFLYANNNIGMTSTNLETDIRSSQKIKDDWTLDGSVSNTMAAYISYSQDMSDHTFSVYVNRPGLSFGYFFRGGGTLSGIQRGIVEFTVEGYNERAFISMNQQQVQQLEIDDGNTIQVVDIDRNKPFAIVLPINAGNITFYDVNRNTVEYWNNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLY1</accession>
    <name>F7KLY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06860</name>
        <name evidence="3" type="ORF">HMPREF0994_07317</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN45470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EPC05031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569239.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN45470">
        <property type="protein sequence ID" value="EGN45470"/>
        <property type="gene ID" value="HMPREF0994_06860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05031">
        <property type="protein sequence ID" value="EPC05031"/>
        <property type="gene ID" value="HMPREF0994_07317"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1632175_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007658703" evidence="1">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN45470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="162" mass="18475" checksum="862977D9AD15D720" modified="2011-09-21" version="1">MQKKQLSVLVLIILCFLLGCNRETPKDESQQNYEDESNISKTNGEELVNINSELLGSTPFDIQIDKTALQTRKETETEVTIKTNLTDWGYTVSSEKGKISDINKNSFIYIAPKDERDDTIKIQLSDYENGISYEYTIPLIFAGNNEHSLDKFKENLSRLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>S2KW39</accession>
    <name>S2KW39_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="10" type="ORF">HMPREF0994_07126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EPC05215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360015.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07126"/>
    <dbReference type="EnsemblBacteria" id="EPC05215">
        <property type="protein sequence ID" value="EPC05215"/>
        <property type="gene ID" value="HMPREF0994_07126"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="255"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EPC05215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="623" mass="71720" checksum="5ECE523CA1FF854E" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>S2KW52</accession>
    <name>S2KW52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_07136</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EPC05225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360030.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07136"/>
    <dbReference type="EnsemblBacteria" id="EPC05225">
        <property type="protein sequence ID" value="EPC05225"/>
        <property type="gene ID" value="HMPREF0994_07136"/>
    </dbReference>
    <dbReference type="GeneID" id="29723817"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="363"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EPC05225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="578" mass="64004" checksum="D97675C4A2374B30" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>S2L9U8</accession>
    <name>S2L9U8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EPC05046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360295.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07295"/>
    <dbReference type="EnsemblBacteria" id="EPC05046">
        <property type="protein sequence ID" value="EPC05046"/>
        <property type="gene ID" value="HMPREF0994_07295"/>
    </dbReference>
    <dbReference type="GeneID" id="29729426"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037618_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="32408" checksum="D19FE510F0709DE1" modified="2013-09-18" version="1">MGVLRFNYHSEVLGMYTDITVTYPTGKYTYNMMCPSENQMGEPGKLRKCYQPGMKFPTVYLMHGGGDDDTTFQRMSRVEFYAEQNNVMTVTPQVKDSFFLDTKYGIRYFTYITEELPVLIRSLFASSPEREDNFVVGMAMGGNGALEVSMRRPDLYAACVDLSGGIGCSIDTDNLIEQIKTIQSLPKLQGAFGNPDQIPGSEYDLAEYAKRNMQEHIPVPELFLAVGKDDFIRDVVRRDRDALLKMGYSLTYEEPEGYSHDWIFWDAYLKKTFYEWLPIRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJA0</accession>
    <name>S2LJA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EPC05068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07289"/>
    <dbReference type="EnsemblBacteria" id="EPC05068">
        <property type="protein sequence ID" value="EPC05068"/>
        <property type="gene ID" value="HMPREF0994_07289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="34737" checksum="3170CC1F249C0546" modified="2013-09-18" version="1">MEGIKKRKGKNLKKLIRQQWQYYMLIALPLLYIIIFCYVPMPGVLMAFERYSPSKGLLHSQWVGMKNFIQFFSSPSSVRIIWNTLRIGLYSLIAGFPIPIIFAIAVNEISAKKYKKVVQMVTYAPYFISTVVLVGILNQVLDLRLGIVNQIITLLGGTPVNFMGEPKLFDHLYVWSGIWQSMGYNSVIYIAALTGVSRELQEAAIVDGATRLQRIWHVDLPAIRTQIIVLLIFNVGSVLNIGFEKIYLMQNKVNQQTSEVLATFVYKVGLVNADYGFSAAVGLFNAVVSIILLTATNTIAKKVSDTSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2M3</accession>
    <name>F7K2M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250051.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00102"/>
    <dbReference type="EnsemblBacteria" id="EGN42719">
        <property type="protein sequence ID" value="EGN42719"/>
        <property type="gene ID" value="HMPREF0994_00102"/>
    </dbReference>
    <dbReference type="GeneID" id="29725797"/>
    <dbReference type="HOGENOM" id="CLU_694062_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="390" mass="46152" checksum="10C7B0903121C33F" modified="2011-09-21" version="1">MKRKFKIKGKKIIITIREFLTRLNWLYISIIIMIVIGIGILAASYLVNDNDAKNVCVGLGTGIVTSALVSLYIDAINKKVEKNKLFQYKNMLLNPLYNAIKSLYIHISININEYRVREEISGYLLLPMEKTEDLSNFLNELMSYKLEDMVEEKQKKLVNMLCISEIYYRELISQFRGLPLDSLLYENLISHEDYKKLKNFSLINLCMGNLTKISEDGVSEQDEYVLKIQLLHGMMLQMNRILEVFPDMASKIDSENSWIKNNLAEIYYNEIYTNSEEYFEEMMEKMEAEQKYYAEHPDEWENEAEEETEEDRLYRKINKAIWAGNAETIKKCFPEINKDNKQIQSELTWSLARNVMKDKELRSMYFEKYGEKYKMRKDKRKGLKRKCGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2T7</accession>
    <name>F7K2T7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional folate synthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Dihydroneopterin aldolase</fullName>
                <shortName evidence="10">DHNA</shortName>
                <ecNumber evidence="10">4.1.2.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">7,8-dihydroneopterin aldolase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
                <ecNumber evidence="10">2.7.6.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
                <shortName evidence="10">PPPK</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
                <shortName evidence="10">HPPK</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_00166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250115.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00166"/>
    <dbReference type="EnsemblBacteria" id="EGN41762">
        <property type="protein sequence ID" value="EGN41762"/>
        <property type="gene ID" value="HMPREF0994_00166"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.176"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023499_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="11">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN41762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="32181" checksum="83DF11E7AF5241BA" modified="2011-09-21" version="1">MKDQIRITGLEVYAHHGVFPEEKEKGQHFFLDAVLYTDIRKAGLTDDLDCATDYGQVCKLINQVMTGQTYDLIERAAERVAQEILLTFPLVERLELELHKPEAPIPYPFGDVSVKIERGWHKVYIAFGSNMGEKEYYLEKGLDELKRHPLCKSGKMSSIYRTSPYGGVEQEDFLNGVLELYTLLSPFELLEKMQQVENLAGRERKVHWGPRTLDLDMLLYDDQIIDSEKLTVPHADMQNRDFVLVPLCEIAPYVRHPSTGKTIKQLLETLQMGGERHVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Z7</accession>
    <name>F7K2Z7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250175.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00226"/>
    <dbReference type="EnsemblBacteria" id="EGN37865">
        <property type="protein sequence ID" value="EGN37865"/>
        <property type="gene ID" value="HMPREF0994_00226"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.246"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN37865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="338" mass="37111" checksum="C3D8CEB32F81DE62" modified="2011-09-21" version="1">MATIKEIAELAGVSRGTVDRVLNNRGSVNPRTARKILEIAQALDYKPNKAGIVLAAQKKNLKIGVILFDTGNPFFDDVLEGVNRKSRELGGYNCSVLVSRVGFDLEAQLRAMDEMVSQGVNGIVLSPYNDPLICDKINELNAREIPVITTNTDIENSSRLAYVGCNFYRSGETAAGLMHLIAGDEVYAGIVTGSSKVLCHTDRIAGFRDRIQSHYPGIRIIDTIENSDDEFESYDRTLRLLKEHPEINGLYFAAGGVYGGCRAVLAAGRKDITIISCDKVSTTREMVLQGVIAATICQQPLIQGTKPLDLMFSCLTTGEKPEKEYHYTTVDIRICENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K369</accession>
    <name>F7K369_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proton_antipo_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250247.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00298"/>
    <dbReference type="EnsemblBacteria" id="EGN33439">
        <property type="protein sequence ID" value="EGN33439"/>
        <property type="gene ID" value="HMPREF0994_00298"/>
    </dbReference>
    <dbReference type="GeneID" id="29725642"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="118"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="531" mass="58140" checksum="2ECE0FFBF8AEE6C3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3B5</accession>
    <name>F7K3B5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate adenylyltransferase, GlgD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250297.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00348"/>
    <dbReference type="EnsemblBacteria" id="EGN33489">
        <property type="protein sequence ID" value="EGN33489"/>
        <property type="gene ID" value="HMPREF0994_00348"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.376"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="380" mass="42514" checksum="E482B25EB5BA731C" modified="2011-09-21" version="1">MVNSNANALGIIFPNGYDSLVPELVAERLMASIPFAGRYRMVDFVLSSMVNCGIDNVSVIVRKNYHSLMDHLGSGRAWDLTRKNGGLNIVPPFAEKTVKVYNGRVEALASILDFLKDQKEKYVIMSEANIAANFDFKAMLNAHIESGADLTLAYAQEEIPKGLIKPFDINKDLYYTLDIEDGRVKEIQINPETPGVQNLSMNIYIMDRELLISQVSAAFVRGHVYFERDIVAPQLDKLNVQAYKFTGYLARISSIKSYFDENMKLLDDENLDALFGSNHIYTKIRDDNPTRYMEGARADNIMAADGCIIEGEVENSILFRGVKVGRGAKVKNCVLMQDTVIEPGAELEYIISDKDVTITADKKLKGTDSFPVYVAKYQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3F4</accession>
    <name>F7K3F4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250336.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00387"/>
    <dbReference type="EnsemblBacteria" id="EGN33528">
        <property type="protein sequence ID" value="EGN33528"/>
        <property type="gene ID" value="HMPREF0994_00387"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="318" mass="35237" checksum="05D3FD3AB1CBA300" modified="2011-09-21" version="1">MKRKGTAEGRGGSRKRGGPVKFRRIIANWQLYVFLLPALIYFIVFCYGPMYGVQIAFKNFSPSKGIAGSPWAGLEHFKRFFNAYYFWDLIRNTLTISIYSLAVNFILPVLLALLLNEMKKGKLKSAVQTATYAPYFISAVVFCGMITTFLSPASGIINKIIEAAGGTAVNFLTTPKLFPSVYVWANAWQATGWGSIIYLATLSGVDEQLHEAAMIDGANRLQRILHINIPHLLPTMITLLIMNAGSLLSVGYEKLLLLQNPLNTETSEVISTYVYQAGLVNAQYSFATAVGLFNSVINLIILILVNTLSRRISDTSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3P4</accession>
    <name>F7K3P4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250422.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00473"/>
    <dbReference type="EnsemblBacteria" id="EGN48191">
        <property type="protein sequence ID" value="EGN48191"/>
        <property type="gene ID" value="HMPREF0994_00473"/>
    </dbReference>
    <dbReference type="GeneID" id="29726202"/>
    <dbReference type="HOGENOM" id="CLU_2734865_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="71" mass="8682" checksum="5E8BD5B24AF497C5" modified="2011-09-21" version="1">MAEQIQNLEQAEKILDYWYAIEFLAQDKFDDMWEIRSKFLRAQDAFTISVMKWHQQDIKHLPNILKIKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Q5</accession>
    <name>F7K3Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250433.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00484"/>
    <dbReference type="EnsemblBacteria" id="EGN48202">
        <property type="protein sequence ID" value="EGN48202"/>
        <property type="gene ID" value="HMPREF0994_00484"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50327H3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577210_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="473" mass="55900" checksum="7E0E19BE48143DCE" modified="2011-09-21" version="1">MNKIIQSLVQTIPKNLSGSYLVKTTEVFVPYKEIGIECLTREITEINLFFESILKFIDIGVQDIDEVAHILGVDYAIIKEVVVDMIEQKYLVTTENKIIMTPRGRRALETRKLVTIQKRFINQVLVNLITGEIVSGDGIFTTRVEKNDICLNEELVVDKAYLENHHNTINEIFQKYQVEDNVFGRHSITRELYKILDLAYEKLVYIKNQLYVYKNFDAEEYQFAFKKDINEQYVNCFYRQVKDVVPPSLENFFERDYSFASSHSKNVPLDNILLEKTQLLCKLLNDSGDVIQKSIEEQFKNKRYMLTDDEYRNFFLHGSEFIWDKLIIVSGRLKKLFDNRIWGEIRNLSRNKEIYIVFDEKEYGIENELNKLKSNSVKRQNIILIKRNGLSQNNICFFPAVSIGIDEEVYEMFKRPVTLRKGIIEFEKESIEETVNQIQTDFNIIFNNENKDKNDTRDQKINRKFSKRSYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3S7</accession>
    <name>F7K3S7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250455.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00506"/>
    <dbReference type="EnsemblBacteria" id="EGN45510">
        <property type="protein sequence ID" value="EGN45510"/>
        <property type="gene ID" value="HMPREF0994_00506"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.555"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100170_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN45510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="195" mass="22447" checksum="67C75659FDEF1EE2" modified="2011-09-21" version="1">MPPKAKISKEMILDTVLDITRQAGFDAVNARSIADKLQCSTRPLFTCYKNMDELKSEFLDFAFEFYNQYVADYRASVNTDSCLILPLSYVAFARDETNLFKLLFINDMDLDMTEAKDFYKEVGNEEKAKIFSDSIGVELERGKTIFLDLFLYTHGIAVLTATGKLTFDRNNVEKMLKNLLSAFIKQEKPDWKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K409</accession>
    <name>F7K409_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheD</name>
        <name evidence="4" type="ORF">HMPREF0994_00595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250544.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00595"/>
    <dbReference type="EnsemblBacteria" id="EGN44783">
        <property type="protein sequence ID" value="EGN44783"/>
        <property type="gene ID" value="HMPREF0994_00595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.647"/>
    <dbReference type="eggNOG" id="COG1871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087854_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN44783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="158" mass="17311" checksum="33B267847910EE00" modified="2011-09-21" version="1">MDKEIKVGIADMKVARVQGLLITYALGSCIGVTLYDPVIKLGGLLHIMLPSAENVSGDNVYKFADSGIREMLRKMQAFGGMKVRYVCKIAGGAKMFEMQGSLGNIGQRNIQSVQNVLRQEGIRIVRQDVGANYARTLSMDVETGTVKVRSYGRPEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4B6</accession>
    <name>F7K4B6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250644.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00695"/>
    <dbReference type="EnsemblBacteria" id="EGN44044">
        <property type="protein sequence ID" value="EGN44044"/>
        <property type="gene ID" value="HMPREF0994_00695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.754"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN44044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="326" mass="37582" checksum="CEE9DC4D208C3E22" modified="2011-09-21" version="1">MIYVILAALALAAICFSIRFYALKHSIREACRELEEIRKEPDQDRILHISVPDRSMEKLLQSMNLTLKEIRSEGQQYRKREKQFQEQIENISHDLRTPLTVILGYLRLLREKEGTEYKGAELEEILGLMERKARFLEQLVSRFYSFSRLTAGDFRLKLCRIDAGRILRETLTDNYRVLQETRLTVDADIPEHPVWIWGEQEALERIFSNLCQNAGRYAESFLRISVNEKKEQTEIYFENDTNRITEEEAEHLFERFFVPDNSEKQGSTGLGLTIARYLAEAMGASLEADLTGAAGSETGKKGSAAGVIRFTLRFSKGQIRAISEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4J2</accession>
    <name>F7K4J2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250720.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00771"/>
    <dbReference type="EnsemblBacteria" id="EGN43480">
        <property type="protein sequence ID" value="EGN43480"/>
        <property type="gene ID" value="HMPREF0994_00771"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.836"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="285" mass="31730" checksum="944CFB90A2CB3D5E" modified="2011-09-21" version="1">MKKKKFSLGMPLVYLLLIVWALTTIYPLIWVVMNSFKDKKQIVSNSFALPFGGLFTLDNYEKAINKFSIFTAYRNSLIISCTVAAVVILFAGLASYALVRYKFRGSNLMNSLVIAAMMFPVFATIIPVFRMESSWGIVNTNNLWLALLSCALPQIAGNLAFAIVVLSGYIKGLPVELEEAAYMEGCNAYQIFFKVIMPLTKPSFATVGIFSFLWSYNDLFTQTFFLRFPNHWAITRLLSEISGKQGTDYGLMAAAVSLIVVPLIVVYVCLQKYIIKGMTAGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4P2</accession>
    <name>F7K4P2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250749.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00800"/>
    <dbReference type="EnsemblBacteria" id="EGN43509">
        <property type="protein sequence ID" value="EGN43509"/>
        <property type="gene ID" value="HMPREF0994_00800"/>
    </dbReference>
    <dbReference type="GeneID" id="29725749"/>
    <dbReference type="eggNOG" id="ENOG503445Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1439399_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="188" mass="20860" checksum="D64E16BA5E8ADEED" modified="2011-09-21" version="1">MKKQLTMRRVICYLLYFLFVCMLVFGITNARYYITGAGTGSAQAAAVAMNSTIDLTKELNELKPGNTKTITFAVNNYKEEGKISEVAQDYSITVTTTGNLPLQYELSLEDETQKDSVITGNYVKWETPSQGSFSTIWNGGYLPHSVEEEHTYVLAVTWPGDENQDSYADEIDLITLTVDAKQAGAKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Q3</accession>
    <name>F7K4Q3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ORF">HMPREF0994_00832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250781.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00832"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="EGN43384">
        <property type="protein sequence ID" value="EGN43384"/>
        <property type="gene ID" value="HMPREF0994_00832"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.908"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_9"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN43384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="483" mass="52924" checksum="2281681BF9C68225" modified="2011-09-21" version="1">MTEKSIYEQAKVTDKPGEECGVFGMYDFDGSDVSGSIYYGLLALQHRGQESCGIAVSDTSGPKGKVLSVKDMGLVNEAFNPENLEKLKGDIGVGHVRYSTAGSSTRENAQPLVLNYVKGTLALAHNGNLVNAPELRRDLAYTGAIFQTTIDSEVIAYYIARERLNSKSAEEAVGRAMGKIKGAYSLVIMSPRKLIGARDPYGFRPLCIGKRDNAYILTSESCALDTLGATFVRDVLPGEIVTITPEKGIISDTSMCISKEEHARCVFEYIYFARPDSYIDGVSVYHSRILAGKFLAMDSPVEADIVVGVPESGNCAAMGYALQSGIPYGTAFVKNAYIGRTFIKPKQKTRESSVQVKLNALKEVVNGKRVIMIDDSIVRGTTSDRIVHMLREAGAKEVHMRVSSPPFLWPCYFGTDVPAREQLIAYNRSVDEICKIIGADSLAYLRTERLDEMVNELGICKGCFTGKYPIDPPEEDIRGEFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4R9</accession>
    <name>F7K4R9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250797.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00848"/>
    <dbReference type="EnsemblBacteria" id="EGN43400">
        <property type="protein sequence ID" value="EGN43400"/>
        <property type="gene ID" value="HMPREF0994_00848"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.926"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086294_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357085" evidence="2">
        <location>
            <begin position="45"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="31632" checksum="3BA95CB53CABA021" modified="2011-09-21" version="1">MLKKLLKHEWKETWRIPALACALMIILTLVSVICFTRMSPPANADELNAGAFVLMMFYVLTISCVSVVVSIYIAVRFYKNLYTDEGYLMHTLPVTPRQLLVSKLTVGSLWSFLVTILTLWAVFLIMIFGLPVMVKDDLNLSFTLLVNYAKEYSHALFGMSLPVFTVFMFFYFLISAVSNVLIVYGAVSLGQMFSKHKVMASILCYIGVTIIIQTLTSLAMTPYLTKMVVTHVGNSTSLEIPEFMGAFMRNTFIFSLVACVLTGIGCYILSEYLMKKQLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K534</accession>
    <name>F7K534_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBECR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250921.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN43281">
        <property type="protein sequence ID" value="EGN43281"/>
        <property type="gene ID" value="HMPREF0994_00972"/>
    </dbReference>
    <dbReference type="GeneID" id="29725167"/>
    <dbReference type="eggNOG" id="ENOG50331NC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118498_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041420">
        <property type="entry name" value="PBECR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18813">
        <property type="entry name" value="PBECR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBECR4" evidence="1">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="195" mass="22771" checksum="9FD79C6C47F59BEA" modified="2011-09-21" version="1">MDLLMECASVFKNLMNYQYRFTLGRKGKLKVITLGFSETDFHHLVGLHKLRDTEVARANRGAVFKAIVSGRITYATIIKSTFIEEILSRLQTFPNLESLLDHDQLVFRYNKKVYPYSSIESEFLLKMGDGSILDITFLFLDKTEQGIYYCRSFFPMERTDYTKEQMQYTLLKKEKIDIRSGVAAVQYDRLTPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5B4</accession>
    <name>F7K5B4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH dtxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250992.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01043"/>
    <dbReference type="EnsemblBacteria" id="EGN43016">
        <property type="protein sequence ID" value="EGN43016"/>
        <property type="gene ID" value="HMPREF0994_01043"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1141"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="121" mass="13432" checksum="36CEBC44D5A18234" modified="2011-09-21" version="1">MAVGESSENYLETILILSKAHPVVRSVDIAEELGFKKSSVSVAMKNLRELGHITVSKEGFINLTASGHEIADMIYERHQLLSAWLVKLGVDEKTASEDACKIEHVISKESFEAIKKHVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5F2</accession>
    <name>F7K5F2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251030.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01081"/>
    <dbReference type="EnsemblBacteria" id="EGN43054">
        <property type="protein sequence ID" value="EGN43054"/>
        <property type="gene ID" value="HMPREF0994_01081"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369118_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="650"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="754" mass="87332" checksum="A7109EEE2C321DCE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K620</accession>
    <name>F7K620_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01299"/>
    <dbReference type="EnsemblBacteria" id="EGN42331">
        <property type="protein sequence ID" value="EGN42331"/>
        <property type="gene ID" value="HMPREF0994_01299"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1420"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131462_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363533" description="EamA domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN42331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="12691" checksum="9C4ACE06EDEF4244" modified="2011-09-21" version="1">MKISIYYFLLFAGVLAASFSQVLLKKAAGKQHKSFLREYLNPWVICGYMLLLGSTVFNISGLRGLSFMNGPVIESFGYVLVLFLSRFFFEEKITIRKLAGVGCILAGVIVYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6B1</accession>
    <name>F7K6B1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251348.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01399"/>
    <dbReference type="EnsemblBacteria" id="EGN42261">
        <property type="protein sequence ID" value="EGN42261"/>
        <property type="gene ID" value="HMPREF0994_01399"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1521"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="633" mass="72778" checksum="1C988D9A79FC89C3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6R7</accession>
    <name>F7K6R7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251528.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01583"/>
    <dbReference type="EnsemblBacteria" id="EGN42057">
        <property type="protein sequence ID" value="EGN42057"/>
        <property type="gene ID" value="HMPREF0994_01583"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1730"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076559_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="31418" checksum="8529E8C5357B5C13" modified="2011-09-21" version="1">MLEKVVLELGWEPAAEEIEELREGLALYQVKLESGMKEKGEQGEGVVYITDRPDAVRAKMGDEACILLFLTEENRKLEWGNIPYAVESLEGLDGDFLGKVYQRHRGEPWVILETERLVVREMEEGDLEALYRIYDQRDAADFLDGLSEDRDEERAYIKDYIEKVYAFYGFGIWMLEEKSGGRCVGRAGFHMREGFAYPELGFIVAQEDQRKGYCLEACSALLEYGFRELEFDGVQALVAEGNRASEEVCRRLGGTPAEKICWKGKKCLRFVWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6V9</accession>
    <name>F7K6V9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251545.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01626"/>
    <dbReference type="EnsemblBacteria" id="EGN42100">
        <property type="protein sequence ID" value="EGN42100"/>
        <property type="gene ID" value="HMPREF0994_01626"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1777"/>
    <dbReference type="eggNOG" id="ENOG5033FWK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172497_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="107" mass="12616" checksum="BA46CF9FF594C1A5" modified="2011-09-21" version="1">MEVKQLNEAQYMCTMGTKMYDVTESAEAVVNIWNYAKQLLKDNLISKYGFSKKYVEAVYENNEHTYQHILLFTNQKNSYAVIIIDIIHKTILGHYILDLNEKYSLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Z5</accession>
    <name>F7K6Z5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251518.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01569"/>
    <dbReference type="EnsemblBacteria" id="EGN42043">
        <property type="protein sequence ID" value="EGN42043"/>
        <property type="gene ID" value="HMPREF0994_01569"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1715"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="34117" checksum="3923312A21CC8D87" modified="2011-09-21" version="1">MGVSFDSYKTFYYVAKFRSFTEAAKALYVTQPTVTHAIQMLEKELDCILFQRSRKGVSLTPEAAMLYEHVKAACEHIFEAENALKAKKELLEGQIRIGAGETTLHFFLLPYLKQFKTLYPGVKIKVNNTSTPASLSALRAGHIDFAILVMRPDYKGAFLPRDRFSVTRLAGFQDIFIAGNDFSELSGHSVTPPELADYPLICMEPGTVTRQYLDDFFLPYHLTISPDIELATTDLITPMAVNNLGVGFVPRPFAESALKEGKVFEIELTESIPEREICVISRTDTPISLAGNAFLHLFSECPQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K722</accession>
    <name>F7K722_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41903.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359999.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01429"/>
    <dbReference type="EnsemblBacteria" id="EGN41903">
        <property type="protein sequence ID" value="EGN41903"/>
        <property type="gene ID" value="HMPREF0994_01429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="322"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41903.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="438" mass="48778" checksum="CF1D3E020F12B160" modified="2013-09-18" version="2">MGLYEKLVNGEEKLSLVGLGYVGMPIAVAFGRKINVIGYDLNAQKVEQYKAGYDPTREVGDDVIKQANVEFTADETKLKEAKFHIVAVPTPVNDDHTPDLRPVEGASRTVGRNLVKGSIVVFESTVYPGVTEDICVPIMEKESGLTCGVDFKVGYSPERINPGDKVHRLETIVKIVSGMDEETLDTIAKVYELVVEAGVYRADSIKVAEAAKVIENSQRDINIAFMNELSIIFNKLGIDTKSVLEAAGTKWNFLNFFPGLVGGHCIGVDPYYLTYKAEELGYHSQIILSGRRINDDMGRYVAENVVKNLIKADIAVKTARVAILGFTFKENCPDTRNTKVIDIVKELREYGIEPVIVDETADAQEAERLYGVKLAGREAVKDLDALVIAVAHEEFSHLSKEEIAGFFNQAHEKKVLVDIKGILNRRDYMTEEYMYWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7B4</accession>
    <name>F7K7B4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251656.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01743"/>
    <dbReference type="EnsemblBacteria" id="EGN41556">
        <property type="protein sequence ID" value="EGN41556"/>
        <property type="gene ID" value="HMPREF0994_01743"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1903"/>
    <dbReference type="eggNOG" id="COG4586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="345" mass="39202" checksum="9D5E4FD68ADD701C" modified="2011-09-21" version="1">MNIIETTQLTKTFKRYKKQEGLSGSIKGLFHREYEEKEAVKGMDFAVEEGGFVGLIGPNGAGKTTLVKMLTGIIAPTAGEISVMGYYPNKLENDFKRQYAVVMGQKSQLFFELTTEDTLHLFKQIYGLSDRQYQENKEYFVELFGVKELMDVQVRTLSLGERMKMELIVALLHNPRILFLDEPTIGLDAVAGKQVRKFLKEVNEERGTTILLTSHYMEDIKSLCSRCMVVNHGSKIYDGSTEQLFDRYQKNKKITLSFDNPTQFTHKENGWRVLEDTPYKKVFEVPKEKSGECLGTLLELAPVDVTIEEEEIGKVVERIYREGGKSLCSSGGSHFASQIRRDSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7I2</accession>
    <name>F7K7I2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251724.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01811"/>
    <dbReference type="EnsemblBacteria" id="EGN41624">
        <property type="protein sequence ID" value="EGN41624"/>
        <property type="gene ID" value="HMPREF0994_01811"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1979"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="256"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="404" mass="45823" checksum="09B803DF82F31DCC" modified="2011-09-21" version="1">MYCVRNVTEDLYWVGANDHRLTLFENIHPIPRGVSYNAYLLLDEKTVLFDTVDWSACRQLLENMDYLLQGRQLDYLVINHMEPDHGASIEEILLRFPKVTIISTPKAFMLMRQFGFDIDNYTQLEVNEGDTQCFGRHTVTFVNAPMVHWPEAMVTFDVTDGVLFSADAFGSFGALDGKLFNDEVDFERDWIDDARRYFTNIVGKYGAPVQALLKKASKLDIKMICPLHGPVWRSSIGYFIEKYDLWSRYEPEEKGVMIAYASMYGNTEAAAQALAARLCDKGMTNVVVYDVSNTHVSQLISEAFRLSHIVLASVTYNLGIYPVMHSFLSDMKALNLQNRTFALIENGSWACKSGDLMQKFIEGEMKNMTVLNERLSMASTLHPDKVSELETLADGIIASIKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7L0</accession>
    <name>F7K7L0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41653.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360124.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01840"/>
    <dbReference type="EnsemblBacteria" id="EGN41653">
        <property type="protein sequence ID" value="EGN41653"/>
        <property type="gene ID" value="HMPREF0994_01840"/>
    </dbReference>
    <dbReference type="GeneID" id="29728066"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="328"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41653.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="765" mass="86393" checksum="700288B7E25F11C7" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7L4</accession>
    <name>F7K7L4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41657.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01844"/>
    <dbReference type="EnsemblBacteria" id="EGN41657">
        <property type="protein sequence ID" value="EGN41657"/>
        <property type="gene ID" value="HMPREF0994_01844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41657.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="325" mass="36578" checksum="B500160DD2EA8EF1" modified="2013-09-18" version="2">MNKLPVSGTKGKEKNLRPELVRPLRLRLIDDFKKNWILYLMILPVLLYFIVFAYAPMSGVILAFKDFKVKLGIFGSPWVGLKYFERFFGSFNFSLLLKNTIGISLYTLLIGFPIPIIFALLLNYLRLKHLKKTLQMVSYAPYFISTVVICGMIAIFMDKNTGIFNQIIVALGGEAQDFLSKPQYFKSIYVWSGVWQGMGYSSIIYISALSGVDPALHEAAIMDGATKVQRILHIDLPGIKSTIIMLLILQMGSLMNVGFEKVFLLQNDLNMSASDVINTYVYRVGLVQNNYSYSTAVGLFNSVINMALVIAANQLSKKLANESLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7P2</accession>
    <name>F7K7P2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251849.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01936"/>
    <dbReference type="EnsemblBacteria" id="EGN41341">
        <property type="protein sequence ID" value="EGN41341"/>
        <property type="gene ID" value="HMPREF0994_01936"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2126"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_10_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032158">
        <property type="entry name" value="DUF4994"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16385">
        <property type="entry name" value="DUF4994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4994" evidence="5">
        <location>
            <begin position="361"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="487" mass="54796" checksum="5975F9BE401BF07C" modified="2011-09-21" version="1">MTKPNLIYILADDMGYGDISALNENCGFRTPNLDEMAENGICFTDAHATAAVCTPSRYGILTGRYNWRSRLKSSVMGGYSEPLIERGRKTLADMLKDNGYRTAMVGKWHLGMSFAKEEGFVEKPDFDASDHVDYAGKIEDSPVSYGFEYFYGISASLDMPPYIYIENDHFTALPDHVTRGTGKGFFREGPTAPGFEQEKVLDELTDKVLEKIEEYREEPFFLYFPMPAPHTPILPAQQFRGKSGTNEYGDFVLHCDDVAGRINRKLKELGLYENTILIYTSDNGCSPMADYPELLAKGHNPSYVFRGTKADIYEGGHRIPLIVQWPQKVPKGKRCSRTVCLSDIMATMADCLEIPLEPQMGVDSVSSLPLWLDPEGKEVREDLIHQSIDGSLSIRKGKFKLEMCPGSGGWSDPKPGEEPAGAPRFQLYDLSVDIGEKKNVIEEYPEIEKELREILKGHIFRGRSTPGPEQHNDGEPVWETIRWVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7P3</accession>
    <name>F7K7P3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251850.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01937"/>
    <dbReference type="EnsemblBacteria" id="EGN41342">
        <property type="protein sequence ID" value="EGN41342"/>
        <property type="gene ID" value="HMPREF0994_01937"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2127"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356459" evidence="2">
        <location>
            <begin position="32"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="499" mass="54902" checksum="2924F9CED8E5EA8A" modified="2011-09-21" version="1">MKKRMKALAAIALSVCMLAGCGSSQKPAAPAESSAGGGESQAPAAAETGGEEASAGDTDFSGVTLVFAQDLSTDETANALSEEIIKEWETKTGATVKFEKQPTDYRVWLTTQFTANQGPDVYTGIIYDITADYEAGYLHNFKDLYDQESPYDTGKAWKETLPDSILERMYLTDNDVPGYPSSTSVVRIFYNQSLFDAAGVQVPETWDQFMDVCQKLKSAGTTPFAFPNASKDDLSWLWFNNSVCSQLNNDLVEKTDVSGNGFIELNEMVKAFDEGTLDFTSDSIKDSFDLMKDFSQYWTSDYNGLDQKTAIDMFIRGEVAMVQAMSTNLTAISANVGDSFEYGVMAIPVITTDTNKNAMGKSVILGGQPDIIFAVNKACESDPKKLAAAIDFAQFMSSPDVQRRFAEGINRIPLSTSTQLPDRLSGFIITEEPLRLAYYTGVNSELRDFFCRGGQMYLEGTYDTDAFAQYVQDSFKTVFDTIKAEKEWSADNNYGLDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Q8</accession>
    <name>F7K7Q8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251866.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01953"/>
    <dbReference type="EnsemblBacteria" id="EGN41358">
        <property type="protein sequence ID" value="EGN41358"/>
        <property type="gene ID" value="HMPREF0994_01953"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2147"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="38768" checksum="B97F962068FD332D" modified="2011-09-21" version="1">MKIGLIGCGGMGTTHNLSLKALSGKMDVEVTALADCRQEFLERAAKQWPGAKTYTTGMELLREEELDAVHICLPSYLHAEHAIAAMEKGMDVFLEKPVCLTREDCSRLLEVQKKTGARVMVGQVVRSFGEYRYLKDIYEKKTYGKLKSIVMQRISGDTKWGYEDWFHEERKSGSVVLDLHIHDLDFLRYMLGEPDSFTVKAAAFPGGMINQIITSYQFGSVFATAEGIWDVCTELPFEGSFRACFEEATIIYQGRQTPTVQVYHKGGEISVPKLQEEISLHDESAGINISDLGPYYTEIKYFYECLAEDREITRAPLEEGIKSVLLGIEEWEAGKKYIKEYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7R1</accession>
    <name>F7K7R1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251869.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01956"/>
    <dbReference type="EnsemblBacteria" id="EGN41361">
        <property type="protein sequence ID" value="EGN41361"/>
        <property type="gene ID" value="HMPREF0994_01956"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2149"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="361" mass="40830" checksum="8E3F7E48A3428FAE" modified="2011-09-21" version="1">MRKLRIALMGCGRISASYALVFPRLSDIAEFVCAIDIEEEKARAFAAPFGAAWGTRFEDLSDKNIDIVHLCLPHYLHAPAAIRAMEAGMHVLTEKPVSITLQDADRMKAVSERTGKKLGVIFQTRYEESVQQLRRMIQDGAFGHILSARSILTWSRPYSYYEGCDWKGTWDREGGGVLIDQAIHSIDRIRYMLGSEVEWIDGSIHNHYHDRIRVEDTAEAAIHFKNGCLYSLYATNSYASDAPVFMEFQGEKGRCGLKQDIGFYELDGSYTEIRPAPSAESTAIPDYWGMGHYAQIHDFYLSVCNDMPVSVDVTEGRRTLEIVKGIYYSSQRRERIYLPFEDTNYSDLNTPSVSAPPAFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7R3</accession>
    <name>F7K7R3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251871.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01958"/>
    <dbReference type="EnsemblBacteria" id="EGN41363">
        <property type="protein sequence ID" value="EGN41363"/>
        <property type="gene ID" value="HMPREF0994_01958"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2151"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="415"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="515" mass="60266" checksum="3C08CE4FDDCEBDDA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7W3</accession>
    <name>F7K7W3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrolase_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251922.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02009"/>
    <dbReference type="EnsemblBacteria" id="EGN41414">
        <property type="protein sequence ID" value="EGN41414"/>
        <property type="gene ID" value="HMPREF0994_02009"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2204"/>
    <dbReference type="eggNOG" id="COG3773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045092_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356708" description="Hydrolase_2 domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_2" evidence="4">
        <location>
            <begin position="292"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="43042" checksum="6A44755BC0C8EE9C" modified="2011-09-21" version="1">MKTAGRRRLLTGVLTAVLLVSIPVIRAGATSDTKEKLEKAKQEKQATEDQKNATETNIGNMEEAKTGLAGELAGLTTQLTEVSNNLETIENNIIAKNDEIAKTQEELEEAKKTEEWQYTCMKKRIQFMYEQNSQMYLEALFSSSSFSDFLNKSEYFEQIAAYDQKMLAQYKETRKQVEETEARLEKEKEELDEMKASAEAEHEKFSGLINKTKGNISSYSNQIAGAEAQVAALEAQIEEQNKNISALQKQLAEEMAKSRLAANSSWRDISEVSFTEDDRYLLANLIYCEAGGEPYDGQVAVGAVVINRVLSSVYPSTLSGVVYQNRQFEPVSTGRLALALAENRATASCYRAADEAMRGMTNVGNCVYFRTPIPGLEGINIGGHVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Y5</accession>
    <name>F7K7Y5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251944.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02031"/>
    <dbReference type="EnsemblBacteria" id="EGN41436">
        <property type="protein sequence ID" value="EGN41436"/>
        <property type="gene ID" value="HMPREF0994_02031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045984_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3048" evidence="1">
        <location>
            <begin position="63"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="2">
        <location>
            <begin position="256"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="376" mass="43165" checksum="1E9CC715345BB88A" modified="2011-09-21" version="1">MHKRKYWIVLSFLFILSMFMACGNEIHHITPESIDSVAVTEPEKAKDEELQDIPEETNIYSYLTGLPISEEKRNIRPVAVMLSNIESGCPQYGIEKASVIYEAPIETRITRLMGLFENWESIKKIGYIRSSRDYFVYSAMEHDAIYCHFGQATLYVGELLNSGKVDTISAAVAGINHPAKYAFHRTVDRKAPHNVITSGPDILMDVDRFGYSLTYHETFKPKFTFINDKDKDIYKDKTEVKMIYPGGKAVNARNGYGKIQAYFEYKNGKYYRYQYGGPQIDEETGNQLSYENVILQYCYGEVRDENDYLAFGSHGDNGYPVQVFTKGRMIEGTWSRFSDTDPAVYVDEKGENIKLTPGKTWICIIWMEYADDVILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8A1</accession>
    <name>F7K8A1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251787.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01874"/>
    <dbReference type="EnsemblBacteria" id="EGN41279">
        <property type="protein sequence ID" value="EGN41279"/>
        <property type="gene ID" value="HMPREF0994_01874"/>
    </dbReference>
    <dbReference type="GeneID" id="29727577"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2054"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106729_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="163" mass="19175" checksum="7D2F2F23A3F393F5" modified="2011-09-21" version="1">MRVRIQHVEEKKQEEALLRLTGEDVCSAGLKEYIETDSWRMVSLSCRKGGEIHRVKSSEIFYVESVQEVQLIHAEGDVLETRERLYVLEKMLPSSFLRISRSVILNLDRVKRYRPLINGLMEVKLENGELVYISRKYLREVRDRILDNRNEGGISDDKDKHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8B6</accession>
    <name>F7K8B6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">HMPREF0994_01889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251802.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01889"/>
    <dbReference type="EnsemblBacteria" id="EGN41294">
        <property type="protein sequence ID" value="EGN41294"/>
        <property type="gene ID" value="HMPREF0994_01889"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2071"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_2_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="30220" checksum="3658127311CB72CB" modified="2011-09-21" version="1">MIQSKELQGAAVGVFDSGVGGLTVAREIMRQIPNEKIVYFGDTARVPYGSKSQDTVTRYSRQIVRFLRTQDVKAIVVACNTASAYALDSLEKEIDIPIIGVVKPGARVAAEVTRNGKIGVIGTEGTIGSQIYTDFIHNINPDAKVTGKACPLFVPLVEEGLLQDPVTDEIASRYLTELIDIGIDTLILGCTHYPLIRSTVGRIMGEEVTLVNPAYETAAELKKLLTDCNLLNPQAPALGDNKYKFYVSDGAEKFKRFANSIIKYGILSAKTIQIEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8P5</accession>
    <name>F7K8P5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252136.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02235"/>
    <dbReference type="EnsemblBacteria" id="EGN41142">
        <property type="protein sequence ID" value="EGN41142"/>
        <property type="gene ID" value="HMPREF0994_02235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2440"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031340">
        <property type="entry name" value="RsmF_methylt_CI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17126">
        <property type="entry name" value="RsmF_methylt_CI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="108"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="464" mass="51537" checksum="63AD9B71DF5A4366" modified="2011-09-21" version="1">MFPEKFIIRMQEMLGEEYEAFYEALREERHQGLRINTLKAETEGFLKKAPFSLSPVPWTETGFYYEGTVQPGRHPLHEAGVYYIQEPSAMAPAAFADARPGERILDLCAAPGGKSTQLAAAMKGQGILVCNEIHPARARILSENIERMGIRNAVVTNETPERLAERFAGFFDKVLVDAPCSGEGMFRKNEEACGEWSPENVELCAERQDTILDSAAQMLQNGGLLVYSTCTFAPQENEGTISRFLKRYPAFSIVKPGKPECFSPGRPDWIPEPAPGIEATMRLWPHKLKGEGHFLAVLRKEGTLSDISSLPIRKDGNRGASEKECGEFLTFASQSLKGWQGGNYLFFGEQLYLLPPGMPSLKGLKVLRPGLHLGTMKKNRFEPSHALALALKPDEVCLSAELVSGEENKDYGPAFAWLNGETFPLTGEKGWYLITVDGYSIGWGKLAGGIMKNHYPKGLRKNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8U8</accession>
    <name>F7K8U8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252208.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02307"/>
    <dbReference type="EnsemblBacteria" id="EGN41214">
        <property type="protein sequence ID" value="EGN41214"/>
        <property type="gene ID" value="HMPREF0994_02307"/>
    </dbReference>
    <dbReference type="GeneID" id="29726872"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2520"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059357_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="30"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="35307" checksum="C619801720EEA9A1" modified="2011-09-21" version="1">MNDKTISKEAPENILQCWNLSGTAEQIYSTAWQVNDKYVLKRYEDLETLKKNAEMLTVLHEMGIPVAEIIPVPSGDPYACCDERYYMLSKKLPGNNETDIIQEGIAEKMGEILGRLHLAFRKCEERLELWDNSLLDEMNGWVAESLTREKWLDEETFRSAVGNLQDGYDRLPRQLIHRDVHFGNFLFDHGEFSGYIDFDLSQKNIRIFDICYFLTGLLSSQIGSSLDTEEWLRIVKDAAAGYEKWIPLLPEEKRAFPYVMENIELLFAAYFNLPEQADFRNNALKMFYFVRGQEAQIHKMLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8V8</accession>
    <name>F7K8V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nicotinamide mononucleotide transporter PnuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252220.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02319"/>
    <dbReference type="EnsemblBacteria" id="EGN41226">
        <property type="protein sequence ID" value="EGN41226"/>
        <property type="gene ID" value="HMPREF0994_02319"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2534"/>
    <dbReference type="eggNOG" id="COG3201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076589_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="26290" checksum="631B0C58DA1C1466" modified="2011-09-21" version="1">MSRWKAFLKAETADWKKWEAAWLFLAAGIIVLLSLYWGDDARGITAAVTGVICVILTGKGKMSCYLFGLVNTILYAWIAWDARYLGEVMLNVVYYVPMQFAGWFMWKKHRNQETGEVVKTRLSLKGDLAAAGIAAASIYGYGLILKALGGNLPFTDSLSTCLSVLAMLFSVKRLMEQWILWIVVDVVTVYMWAVDYANGGTDIATLLMWSVYLLNAVIMLHKWYVESRRAEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9E6</accession>
    <name>F7K9E6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fn3_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252404.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02503"/>
    <dbReference type="EnsemblBacteria" id="EGN40902">
        <property type="protein sequence ID" value="EGN40902"/>
        <property type="gene ID" value="HMPREF0994_02503"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2744"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="643"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="734" mass="81540" checksum="590117D8171F0614" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9R1</accession>
    <name>F7K9R1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252491.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02590"/>
    <dbReference type="EnsemblBacteria" id="EGN40573">
        <property type="protein sequence ID" value="EGN40573"/>
        <property type="gene ID" value="HMPREF0994_02590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2838"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="14157" checksum="5A6532C40C39ECDC" modified="2011-09-21" version="1">MEIPRIPDGEYRFAELVWDNEPINSTMLIRLAQESLGWKKATSYTVLRKLCEKGILKNENATVTARIKKDAVCRQESEYLLHRSFGNSLPAFVASFLQDKKLTRQEAEELKRLIDAASAGGNEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9R6</accession>
    <name>F7K9R6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cu/Zn superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02596"/>
    <dbReference type="EnsemblBacteria" id="EGN40579">
        <property type="protein sequence ID" value="EGN40579"/>
        <property type="gene ID" value="HMPREF0994_02596"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_8_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Cu" evidence="4">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="17554" checksum="BC7C0A784FFCAEF6" modified="2011-09-21" version="1">MLQLMTDGILRFLANQPKAFAHVKGSEHYPDVQGLVTFYDLMDGTIVMVDISGLPDTGEPCGGKFYGFHIHEGTACTGNDTDPFADAGTHYNPDNCPHPAHAGDMPVLEGNRGRAWTAFYTERFTPEQVKGKTVIIHSMADDYRSQPSGDSGEKMACGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9U9</accession>
    <name>F7K9U9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252533.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02632"/>
    <dbReference type="EnsemblBacteria" id="EGN40615">
        <property type="protein sequence ID" value="EGN40615"/>
        <property type="gene ID" value="HMPREF0994_02632"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085966_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="27568" checksum="5C597BB8AC8472A0" modified="2011-09-21" version="1">MNGLIDIHSHILPLVDDGAESVEMALLMLKKAAEEGIEKIILTPHQKPDRRCVTPEGILRRMEELRELAGKEKIPVQLYPGNEIFYRHGLAELLDKGKIRTMADSRYVLIEFLPGEDYTYIRDALSRVASFGYRPITAHVERYVNVMSRIDKAEELKEDTGCYFQVNAASVTGENGFSVKNMTRKLVKEGLIDFIATDAHRSEGKRSPDMKACAEWVKKKLGEERMEQIFCGNPTALLKDKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAG0</accession>
    <name>F7KAG0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="14">ATP-PRT</shortName>
            <shortName evidence="14">ATP-PRTase</shortName>
            <ecNumber evidence="5 14">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hisG</name>
        <name evidence="16" type="ORF">HMPREF0994_02786</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5 14"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252687.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02786"/>
    <dbReference type="EnsemblBacteria" id="EGN40395">
        <property type="protein sequence ID" value="EGN40395"/>
        <property type="gene ID" value="HMPREF0994_02786"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3049"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_2_0_9"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="15">
        <location>
            <begin position="59"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGN40395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="214" mass="24124" checksum="728CDAF2DBCA1877" modified="2011-09-21" version="1">MDEKRYLTFALAKGRLANKTLELLEEVGITCEEMKDKSSRKLIFVNEELKLKFFLSKGPDVPTYVEYGAADIGVVGKDTLLEEGRRVYEVLDLGFGKCRMCVCGPAESKELLKHHEMIRVASKYPNIAKDYFYNKKHQTVDIIKLNGSVELGPIVGLSDVIVDIVETGSTLRENGLEVLEEVCPLSARMIVNQVSMQMQPERIKGLINQLKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAG6</accession>
    <name>F7KAG6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252693.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02792"/>
    <dbReference type="EnsemblBacteria" id="EGN40401">
        <property type="protein sequence ID" value="EGN40401"/>
        <property type="gene ID" value="HMPREF0994_02792"/>
    </dbReference>
    <dbReference type="GeneID" id="29725444"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3058"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356498" description="SBP_bac_5 domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="133"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="701" mass="79322" checksum="15189037F3E31DA7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAK1</accession>
    <name>F7KAK1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)</fullName>
            <ecNumber evidence="2">3.6.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252728.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02827"/>
    <dbReference type="EnsemblBacteria" id="EGN40436">
        <property type="protein sequence ID" value="EGN40436"/>
        <property type="gene ID" value="HMPREF0994_02827"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3094"/>
    <dbReference type="eggNOG" id="COG1713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089580_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="205" mass="23220" checksum="2743DD922F091867" modified="2011-09-21" version="1">MNKDTKQTQQILTLRKAMAKALEEKRYEHTLGVAYTAASLAMCYGQDVYQAQVAGLLHDCAKNYTNEKRISICKKNGIPINAAEQKNPFLLHAKVGSFLAREKYGVNDKAILDAITYHTTGRPNMSTLDKIIYIADYIEPGRRQAPGLPEVRQLAFISLDDCLFRILKDTLDYLHASKMEIDMSTQQTYDYYKALQCEQKGGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAN7</accession>
    <name>F7KAN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase_S11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_02863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02863"/>
    <dbReference type="MEROPS" id="S11.004"/>
    <dbReference type="EnsemblBacteria" id="EGN40472">
        <property type="protein sequence ID" value="EGN40472"/>
        <property type="gene ID" value="HMPREF0994_02863"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3132"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363846" description="Peptidase_S11 domain-containing protein" evidence="9">
        <location>
            <begin position="41"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="97"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="347" mass="37308" checksum="015BA91792ED23F0" modified="2011-09-21" version="1">MKCTNKRNLKAQGSPVFSRLKKILSRTAVICLLASLPAGALTGCGKEELPFAYNPDYEVSSYRVVNEVSSVVADSFADDLCVVIGDVGTENGAVDMSEATAAGLFDLNKNNVMYAKNVHERLQPASLTKIMTALVALKYGNPDDMITVTDEASITESGAVLCGLKPGDQLTLNQALHALLIHSANDAAAAIAVHIGGSIEGFAEMMNKEALAIGATNSHFVNPHGLTADNHYVTAYDLYLIFNEALKQDLINEIIHMTSYETVYMDKDGNSKSMSLKTTNQYLNGNFKAPEQVTIIGGKTGTTNAAGNCLILLSKDTSGNPYISVILRSKEKQILYTEMTELLNVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAP1</accession>
    <name>F7KAP1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_02867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252768.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02867"/>
    <dbReference type="EnsemblBacteria" id="EGN40476">
        <property type="protein sequence ID" value="EGN40476"/>
        <property type="gene ID" value="HMPREF0994_02867"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3136"/>
    <dbReference type="eggNOG" id="COG2894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="29355" checksum="15BCEA8F0F6D457F" modified="2011-09-21" version="1">MSEVIVVTSGKGGVGKTTTSANVGTGLAAMGKKVVLIDTDIGLRNLDVVMGLENRIVYNLVDVVEGNCRVKQALIKDKRYSSLYLLPSAQTRDKTAVNESQMIKLVEHLKDQLDYIILDCPAGIEQGFKNAIAGADRALVVTTPEVSAIRDADRIVGLLEAHEFSQIDLVINRMRFDMVKRGDMMTPDDVVDILSIPLIGIVPDDENVVIATNQGEPLVGNNTLAGQAYQNICLRVLGKEVPFLDLEHPVSLWARFTGIFHKSQEGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAV7</accession>
    <name>F7KAV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252887.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02986"/>
    <dbReference type="EnsemblBacteria" id="EGN40306">
        <property type="protein sequence ID" value="EGN40306"/>
        <property type="gene ID" value="HMPREF0994_02986"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339TZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181623_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021377">
        <property type="entry name" value="DUF3006"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11213">
        <property type="entry name" value="DUF3006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="70" mass="8225" checksum="A06B3F102E64C5D4" modified="2011-09-21" version="1">MKYIIDRFEEGNAVCEQEDRTMLLISRSQLPSDAKEGDVILYTDGVYQVDKEATLERKKKIEEKRRKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB17</accession>
    <name>F7KB17_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LPXTG-domain-containing protein cell wall anchor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03046"/>
    <dbReference type="EnsemblBacteria" id="EGN40223">
        <property type="protein sequence ID" value="EGN40223"/>
        <property type="gene ID" value="HMPREF0994_03046"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034A9R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276095_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="193" mass="21139" checksum="3044D0DE0BFB8ECD" modified="2011-09-21" version="1">MLIALSAVTVCYAGDIPESLLNSDSAQVYFGEIIDIDGESITVVQRQNIKGEFSKDSVQTYEKYIAQSPTVGEIYLCGFLNEDNPLYIWQVSGLELNDLKIVDAAANSMAERMQNYINEGTFTEKELERQAKAEMNNADETENIPIDTADAAAADNSAAEVSGCSGNILTFVLIVLVIIAAAGLFVFRKRKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB21</accession>
    <name>F7KB21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252951.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03050"/>
    <dbReference type="EnsemblBacteria" id="EGN40227">
        <property type="protein sequence ID" value="EGN40227"/>
        <property type="gene ID" value="HMPREF0994_03050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3331"/>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007352_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="42"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="384"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="699" mass="77491" checksum="14B7CA4AACC8E6DE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB42</accession>
    <name>F7KB42_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_03072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252973.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03072"/>
    <dbReference type="EnsemblBacteria" id="EGN40249">
        <property type="protein sequence ID" value="EGN40249"/>
        <property type="gene ID" value="HMPREF0994_03072"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3357"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="339" mass="36352" checksum="635B767BF62B8CA9" modified="2011-09-21" version="1">MAVKVAINGFGRIGRLAFRQMFGAEGFEIVAINDLTSPEMLAHLLKYDSTQGRYELGDKVSYSEDSITVDGKEIKIYAKANAAELPWGEIGVDVVLECTGFYTSKAKAQAHIDAGAKHVIISAPAGNDLPTIVYNVNHETLSKDDHIISAASCTTNCLAPMAKALNDAFPIQSGIMCTIHAYTGDQMTLDGPQRKGDKRRSRAAAVNIVPNSTGAAKAIGLVIPELNGKLIGSAQRVPTPTGSTTILTAVVKGQPTKEAINDAMKAAANESFGYNTDEIVSSDVIGMRYGSLFDATQTMVLPIDENTSEVQVVSWYDNENSYTSQMVRTIKHFGKLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBB9</accession>
    <name>F7KBB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253049.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39978">
        <property type="protein sequence ID" value="EGN39978"/>
        <property type="gene ID" value="HMPREF0994_03148"/>
    </dbReference>
    <dbReference type="GeneID" id="29728108"/>
    <dbReference type="HOGENOM" id="CLU_1394781_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="195" mass="22107" checksum="5312C8D98E6AB39F" modified="2011-09-21" version="1">MNINSVTPATYTSYVQENQKASRAMMTLEEFKRRCVPCGISSDNDYYSTVEGNISPKGLWPEENFESEEELYKRLAEKYDMTKLQQGDLTTILATLHDAGVLSGTDYGYALSPVPVFSLDEIGAPAGTPLTSWEEPRYNPVSGYNALTDYRQRYTDYIYKYCMDAPPSVIKTVQNAIAVHNKVDDILHEIQKYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBS5</accession>
    <name>F7KBS5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03320"/>
    <dbReference type="EnsemblBacteria" id="EGN40150">
        <property type="protein sequence ID" value="EGN40150"/>
        <property type="gene ID" value="HMPREF0994_03320"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_8_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="265" mass="30237" checksum="A4893B8A554B0EF0" modified="2011-09-21" version="1">MKMGAEMRIGLYQFPGSGDMGQNYKTIEKAVSQAASHKVRFLAFHECALTGYPPLEVPSVSEVDYAAAMKYKECLRKLSIEHSMYIAAGSIEKEEDRYYNSMLLFSPEGRADIYGKRALWGWDRDNFVPGSQMGIYEVDGIRMGIRICFEVRFPEFFRELYRENAELCLVSFCDISQTENKERYELIKAHLRTRAVENVFTVLSVNDISSFQTAPTAVIDPNGAVLLEMERNKEGLLIYDYVRSEDSFGMLGRKRISDELVDGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC01</accession>
    <name>F7KC01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03380"/>
    <dbReference type="EnsemblBacteria" id="EGN39887">
        <property type="protein sequence ID" value="EGN39887"/>
        <property type="gene ID" value="HMPREF0994_03380"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031955_1_2_9"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="7">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN39887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="419" mass="45402" checksum="3EE8DACE4C6F3107" modified="2011-09-21" version="1">MDKQRITIIGIGMGNPGNMTGTGKELLFGAGLVTGAGRMLEACGLQEGSTEERDVIRAYEPEKICRALRNSHKKDAAVLMSGDSGFYSGTKKLLEALENYREEVREWREVSVHVEPGISSLSYFASRLQIPWDDAAVISLHGRKDNLLSAVKRSRKTFLLTGGQTSEICRELTEGGLGDVMVCAGSRLSYPDEHIVKCPAKDWQAAGIPSGQEDSLTVLFLLNEKPERFLMTGIPEECFVRGQVPMTKSEVRAVIMSKLAVREDDVVYDIGAGTGSVSVELALAAGRGQVYAVECDPEGISLIRQNGEKFGCHNLTAVEGMAPEALTGLPAPDAVFIGGTKGRLDPILDAIPGKNRSVRICISAVTMETVSQAIQCMEKKNMRNMDACQIGVTRLRPVGGLHMLQAQNPIFLLWGDMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCC6</accession>
    <name>F7KCC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253413.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03512"/>
    <dbReference type="EnsemblBacteria" id="EGN39585">
        <property type="protein sequence ID" value="EGN39585"/>
        <property type="gene ID" value="HMPREF0994_03512"/>
    </dbReference>
    <dbReference type="GeneID" id="29728590"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3840"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915063_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="31656" checksum="6616B7D91EEF9168" modified="2011-09-21" version="1">MALQRVLVGSPVCERASVLRAFLISLKSLEHEGFLIDYIFIDDNDSEISEKLLKNFKREGSEVTVLPAVKGSAAEDTDARKEARLVRVAGYRNRIIRYAMQKEYDAVFLVDSDLILHPALVEYLRATRKGVISELFWSKSCAGRSSGPNAWLMEERAPNSDKRNAALYKKEADRRKKQFADRLKVSGIYEAGGLGSCTYIDKEAMDKGTRFVPARNPSQNTEEIFFCIQSGTMDIPLFVDTAYPAYHIHGEKDLEGALDYIRSSRGNTLRFPMVKRRKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCX6</accession>
    <name>F7KCX6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253606.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03705"/>
    <dbReference type="EnsemblBacteria" id="EGN38869">
        <property type="protein sequence ID" value="EGN38869"/>
        <property type="gene ID" value="HMPREF0994_03705"/>
    </dbReference>
    <dbReference type="GeneID" id="29728644"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4044"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="334" mass="37312" checksum="692D630ED63C2F8A" modified="2011-09-21" version="1">MNKKNAPTMKDVAREAGVALGTVSKVINGLPVGDAYKEKVEAAIKALDYEVNTYARGLKTQKSNLIALIIPNTTNPFFAAFTDHIEGALYKRGLKLLLCCADGIPEKEVSCLSMATQNKVDGVIALTYSDIGKYIGKDLPIVVFDRFFENHVIPRVASDNYAGACLAIEKLLEFGCRHPVYVRFHSVFPGESDKRKDGYLYACSKHGLEPDYLDMLDNEDLSVQMKDFLYKHKRADNTLSFDGVFAHTDYHGYMFAKLLRQEGYRVPEDVQIIGFDGIHKFGNEDDGLFVSSICQPVRQLAEKCVEILLEEDRSALPSLTLLPVKYQYGGTTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD69</accession>
    <name>F7KD69_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253699.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03798"/>
    <dbReference type="EnsemblBacteria" id="EGN38769">
        <property type="protein sequence ID" value="EGN38769"/>
        <property type="gene ID" value="HMPREF0994_03798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="245"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="349" mass="41021" checksum="76129E6277E1A5B4" modified="2011-09-21" version="1">MEEIFIKWKRYVLDHAEEFRIEDENLSSSEYYVGNTKVCLYSGNPVFNAGMWLQLENHQLRIYVRNDEGEKVIWRSFTDGQMEGPVHQHDFVEIGYVVQGCSAQSFFGKDHVFRQGEFWLVDRHCFHSDKYSTENLFTVYIGIPSEVFDSAFVACIGNTEIQRFLSLALLEQKRTKQFLHFVPRGKMAEGGALMEQLLCEIIEQRVGFYDISKGLLARLLRTLSLDYAFMLTSQEKQKVNDLLFCEVEKYISNNYRTVTIQELVEHFHYNEDYYNRLIKKYSGCTYSEYVKNVRLTEAEKLLRNTELSVEQIAVMSGYQSRGSFYHMFVEKNGMTPAKYRNTERNKLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD72</accession>
    <name>F7KD72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253702.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03801"/>
    <dbReference type="EnsemblBacteria" id="EGN38772">
        <property type="protein sequence ID" value="EGN38772"/>
        <property type="gene ID" value="HMPREF0994_03801"/>
    </dbReference>
    <dbReference type="GeneID" id="29729419"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363675" evidence="1">
        <location>
            <begin position="29"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="569" mass="62907" checksum="896B9A310ABD34AD" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDV8</accession>
    <name>F7KDV8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37562.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360316.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04037"/>
    <dbReference type="EnsemblBacteria" id="EGN37562">
        <property type="protein sequence ID" value="EGN37562"/>
        <property type="gene ID" value="HMPREF0994_04037"/>
    </dbReference>
    <dbReference type="GeneID" id="29729220"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="207"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37562.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="312" mass="34106" checksum="877BA411C7B3AB90" modified="2013-09-18" version="2">MSDIHNLSVMEPPVRLYFSGHEQTSPSHACGPGIWPHYLLHYVLSGTGTFQSEKQSWRLTAGDAFLIIPGVVSAYAASSADPWEYCWIGFDGRDAADILSACGLTAASPVYHSSSPASVDVKAAEGRISPVSGSTDAAPCGLSLCSVKVGEAQAAGDPVGECLLSINDMLYSQPGNTYLHLSLLYRFFSFLSPDAGNAEKNSSAYLQQALDYLQHNYAYVIKIQDVARYVGIDRTYLYKLFTRELGISPQQYLIRLRLSMAKRLLASTDLRITEISNSCGFADSASFCHHFQAHFSITPSQFRKEPGREPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE17</accession>
    <name>F7KE17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253997.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04096"/>
    <dbReference type="EnsemblBacteria" id="EGN36889">
        <property type="protein sequence ID" value="EGN36889"/>
        <property type="gene ID" value="HMPREF0994_04096"/>
    </dbReference>
    <dbReference type="GeneID" id="29729492"/>
    <dbReference type="eggNOG" id="COG1078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051349_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="52"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="354" mass="41094" checksum="7FCA30D83771A3D5" modified="2011-09-21" version="1">MLLNQIYHSEIPLFLREFSATDALLRLKSIGMDCGCEYTNFPAYKHSIKYNRYEHSLGTALIIWHFSMDMKQSVAGLLHDISTPVFSHSIDFLNNDYLLQESTEEDTEKIIYQSGQLMQLLKKYAISLEEVCNYHIYPIADNNSPKLSADRLEYSFRKFQSFGLKSLNDIISYYSDLIIGMNEDQENEIMFTSSELALDFSLCSLKNSINDVSDDDRFAMKFLADILHYALNREILTREDLYTTESQVISKLMSVQETRKAWEIFRNLSHTKRTLDNPFHNNSLPQNIVPSPFSQSDLSPSPGWITLSAKKRYINPYVQSHGRIMEISDKLNQEIQKFLDLKMDYWITATTDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE77</accession>
    <name>F7KE77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254057.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04156"/>
    <dbReference type="EnsemblBacteria" id="EGN36949">
        <property type="protein sequence ID" value="EGN36949"/>
        <property type="gene ID" value="HMPREF0994_04156"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4529"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="314" mass="35103" checksum="96FBBA9DCA2821AB" modified="2011-09-21" version="1">MAVKVRNVYKKGKGVAIGKRLKRDWQIYMFLLPTLLYFFIFCYIPMAGIQIAFKEFTPYMGIFKSPWVGMEQFKRFFDSYQFKTVITNTLKISLSNLVFGFPVPILLALMINQLNFTKLKKVLQTATYAPHFISIPAVVGMIVIMLSPGGLLYNLLNWVTNGKAGIPMGSEKWFCPIFVISEIWQHAGWDAIIYIATLTSVSPDLYEAAEIDGAGKLQKILYIDIPSILPTAVVLLIMNSGRIMSVGFEKVLLMQNPMNISASEIISTYVYKTGLIGMEYSYSAAIGLFNSIINLILILSVNGIAKRAGNVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEF6</accession>
    <name>F7KEF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04238"/>
    <dbReference type="EnsemblBacteria" id="EGN36518">
        <property type="protein sequence ID" value="EGN36518"/>
        <property type="gene ID" value="HMPREF0994_04238"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4627"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN36518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="344" mass="38788" checksum="F53758AD41AD4FE7" modified="2011-09-21" version="1">MLAVFYCLAAVAEIRQAAAFRGEPTKKERPEGFSGIEVIMELCLEQVSKSFQDNRAVDDVSLRITPGVWGLLGANGAGKTTLMRMIAGILKPDKGRITYDGIRIDSLGEAYRDIFGYLPQEFGFYPEFTVRDYLEYMAALKGLKPGWSRRKIGELLETLTLEEVKNKKIVRLSGGMKRRVGIAQALLNEPEILILDEPTSGLDPGERVRFRNLLSEFAHDRIVLISTHIVPDVEYIAMKNAVMKDGKIIETGTTPELVKRMEGKVFSEKIPARALADYEKKLCIVNLKNEPDGDITIRYLGDRPETEDSVSEEPRLEDLYLWLFPQNTDGRKTEERGTKGGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEQ0</accession>
    <name>F7KEQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase (Ferredoxin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HMPREF0994_04329</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254230.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04329"/>
    <dbReference type="EnsemblBacteria" id="EGN35639">
        <property type="protein sequence ID" value="EGN35639"/>
        <property type="gene ID" value="HMPREF0994_04329"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4725"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGN35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1514" mass="167757" checksum="BC35335B2FBA7AA6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEU1</accession>
    <name>F7KEU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254273.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04372"/>
    <dbReference type="EnsemblBacteria" id="EGN35682">
        <property type="protein sequence ID" value="EGN35682"/>
        <property type="gene ID" value="HMPREF0994_04372"/>
    </dbReference>
    <dbReference type="GeneID" id="29723878"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4771"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356567" evidence="2">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="479" mass="52956" checksum="34490F18685B3513" modified="2011-09-21" version="1">MNKWKKNVAIILTVVLAVGMTAACGSNKDTPASGESVSSSESAVAGNESQNNKDSGDVYELDFYAWSNPDNITPLIENFNNDYAGKYNLVYQKLADAMTLTINTALASGEKIDVMTQASHTDLRQRADDGVYLGLKQFFDKEGWDYAEKLGTAIEETQNINGDYYSIPYCNNINMVFFNKNLFDEAGLDYPQSGWTWEEFRETANKLTSGSGADKVYGAMIDTAGSSGSDNYWDLIARQKLGNNVYYNDDLTASTFGSDEMRESLQFFVDMTFKDQCIVPVEEMTALQYNNDPVGMAGLYNGKYAMWIAPVYGCLYLKSSYGDIPEGTDIGMVDMPTPDGGETITTCYSSTASIPANVENPEAAWELLKYICIDRPDLFAGPKAMHPAVEFDKEEDKRAFNELIFSEKPGLDYDMAMDTMMKDRTLVSKDCTIKQGYVAIQEGMENIMSLVFSGEMGVEEALSELQQSVDAAITADLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEV6</accession>
    <name>F7KEV6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254293.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04392"/>
    <dbReference type="EnsemblBacteria" id="EGN35702">
        <property type="protein sequence ID" value="EGN35702"/>
        <property type="gene ID" value="HMPREF0994_04392"/>
    </dbReference>
    <dbReference type="GeneID" id="29725231"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4791"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="160"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="337"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="442"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="791"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN35702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="905" mass="103359" checksum="131BDDA163C11625" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEW4</accession>
    <name>F7KEW4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_04400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254301.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04400"/>
    <dbReference type="EnsemblBacteria" id="EGN35710">
        <property type="protein sequence ID" value="EGN35710"/>
        <property type="gene ID" value="HMPREF0994_04400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4802"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="186"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="8">
        <location>
            <begin position="272"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="10">
        <location>
            <begin position="709"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="811" mass="91567" checksum="BF4AE333809CA467" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFC7</accession>
    <name>F7KFC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04556"/>
    <dbReference type="EnsemblBacteria" id="EGN35325">
        <property type="protein sequence ID" value="EGN35325"/>
        <property type="gene ID" value="HMPREF0994_04556"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="292" mass="31618" checksum="DE56E43C31A372EC" modified="2011-09-21" version="1">MLQKALEEGYAVGSFSARYLTNIGPVLEAAVRQSSPVIVQVSQKEMKRYGSTCGQFADEYRRCIREMDIRVPAALHLDHTKDLDIIQAAIDAGFDSVMIDASEQPLEKNIEIVKKVVAMAHAKGVEVEAEIGKISANDLIETDSTTQLYTDPQEAGYFAKETAVDFLAVSVGTVHGAYGTRKPHIELERIREIREQVAVPLVLHGASGVPSHLIKAAISLEGGGVSKINVATDLETAFLSALGLDGSITNEAVLKLSAGQKLPLGQLDKAHEAVTRVVEEKMRDYLLSSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFQ6</accession>
    <name>F7KFQ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254586.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04685"/>
    <dbReference type="EnsemblBacteria" id="EGN34805">
        <property type="protein sequence ID" value="EGN34805"/>
        <property type="gene ID" value="HMPREF0994_04685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5116"/>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009096_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="3"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="571"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="691" mass="78140" checksum="16A913769699CD81" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFR4</accession>
    <name>F7KFR4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_04693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254594.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04693"/>
    <dbReference type="EnsemblBacteria" id="EGN34619">
        <property type="protein sequence ID" value="EGN34619"/>
        <property type="gene ID" value="HMPREF0994_04693"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5123"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_2_0_9"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="346" mass="38578" checksum="40F7882AA923172B" modified="2011-09-21" version="1">MGVQKELFGTDKEGKEVYLYTLSNSRGMKAKVMNYGAILVDLIVPDKEGRTADVVLGYDKLSEYFVNGCFFGAVIGPNANRIANARFILDGVEYHLDPNDGMNNLHSHKELGVHKRIWETQEIENGVVFSVDMPDADLGFPGNKTLKVTYSVNEENELKLEYSGISDKNTIINMTNHSYFNLDGHDAGDISEHQVTIHAKYFTEILPGAIPTGRLVPVEGTPMDFNTPKKIGEEIDKEWDQLEMVGGYDHNWCLDNYDGKVRLVASVTNPSGSRTMKVFTDLPGVQFYTSNGMAEQTGKGGANYGSRTAYCLETQFYPDTANEPDFPSAVFGPDKDYHSITIFRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFZ6</accession>
    <name>F7KFZ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Meso-diaminopimelate D-dehydrogenase</fullName>
            <shortName evidence="10">DAPDH</shortName>
            <shortName evidence="10">Meso-DAP dehydrogenase</shortName>
            <ecNumber evidence="5 10">1.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_04775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13561"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58556"/>
            <dbReference type="EC" id="1.4.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the diaminopimelate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.16" evidence="5 10"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34402.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360155.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04775"/>
    <dbReference type="EnsemblBacteria" id="EGN34402">
        <property type="protein sequence ID" value="EGN34402"/>
        <property type="gene ID" value="HMPREF0994_04775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055796_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047850">
        <property type="term" value="F:diaminopimelate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010190">
        <property type="entry name" value="Diaminopimelate_DH_Ddh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032094">
        <property type="entry name" value="Meso-DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16654">
        <property type="entry name" value="DAPDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025648">
        <property type="entry name" value="DDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01921">
        <property type="entry name" value="DAP-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAPDH_C" evidence="12">
        <location>
            <begin position="122"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR025648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR025648-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN34402.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="328" mass="36292" checksum="7E2253F4CC467709" modified="2013-09-18" version="2">MSIRIGILGYGNLGRGVECAIRQNPDMELAAVFTRRDPKTVSIQTEGVPVCKIEEAFHWKDKIDVLILCGGSATDLPVQTPEFAGYFHVIDSFDTHAKIPEHFAAVDAEAKKSGKVGIISCGWDPGMFSLNRLYANAILPQGKDYTFWGKGVSQGHSDAVRRIEGVADARQYTIPVKEALDSVRAGENPDLTTRQKHTRECFVVLEEGADKARIEEEIKTMPNYFADYDTTVHFISEEEMERDHSGIPHGGFVIRSGKTGWEEEYGNVIEYSLKLDSNPAFTSSVLVAFARAAYRLGQEGQSGCRTVFDIAPSYLSAKSPEELRSTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG34</accession>
    <name>F7KG34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254714.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04813"/>
    <dbReference type="EnsemblBacteria" id="EGN34440">
        <property type="protein sequence ID" value="EGN34440"/>
        <property type="gene ID" value="HMPREF0994_04813"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5256"/>
    <dbReference type="eggNOG" id="ENOG5033G93">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452108_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="179" mass="20604" checksum="82AB152734909CEC" modified="2011-09-21" version="1">MKKQLNRYKFDKISNMMAKEFGKIERGKEDDYNIIFAPMEGNLLKLHRENEKRNGRVAIEAIHVCLLLIDGYLTDTEYDLNGYRTPENEAFVTGLLMSFDPFTNDEVKAAASGYWDFTSPSDLRAYFQVPVICLLRLEKSIETWTKNMGTNGYFDFLEQTIGATVAGDLKMNYSFMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG88</accession>
    <name>F7KG88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mgsA</name>
        <name evidence="4" type="ORF">HMPREF0994_04875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04875"/>
    <dbReference type="EnsemblBacteria" id="EGN34502">
        <property type="protein sequence ID" value="EGN34502"/>
        <property type="gene ID" value="HMPREF0994_04875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5319"/>
    <dbReference type="eggNOG" id="COG1803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120420_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="157" mass="17663" checksum="A9C8154AC60073D1" modified="2011-09-21" version="1">MMNEEFLTLTIGKQKNIALIAHDSKKPELISWCEEHKDVLKNHFLCGTGTTARMITDKTGLPVKGYNSGPLGGDQQIGARIVEGRIDFVIFFSDPLTAQPHDPDVKALLRISQVYDIPIANNRATADFLITSTLMDQEYDHQIVNFKRNIEHRANTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGA9</accession>
    <name>F7KGA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254768.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04867"/>
    <dbReference type="EnsemblBacteria" id="EGN34494">
        <property type="protein sequence ID" value="EGN34494"/>
        <property type="gene ID" value="HMPREF0994_04867"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5310"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="135"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="607" mass="70320" checksum="CBC16D2FB3DCC1B3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGK7</accession>
    <name>F7KGK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254887.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33781">
        <property type="protein sequence ID" value="EGN33781"/>
        <property type="gene ID" value="HMPREF0994_04986"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5446"/>
    <dbReference type="eggNOG" id="ENOG5033C1J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175291_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019644">
        <property type="entry name" value="DUF2508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10704">
        <property type="entry name" value="DUF2508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="83" mass="9555" checksum="22C2822EED1CB9A1" modified="2011-09-21" version="1">MKFHFSQGSVNKEDKPLTYQESLMLDIQKTKCELENAYAGFDYVTDPDLIDCYIYEQNAVMKRYKYLLQKAASLKASEQAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH52</accession>
    <name>F7KH52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006773350.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05188"/>
    <dbReference type="EnsemblBacteria" id="EGN33221">
        <property type="protein sequence ID" value="EGN33221"/>
        <property type="gene ID" value="HMPREF0994_05188"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QBM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1842380_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="139" mass="15424" checksum="A1FD5DF5781134FA" modified="2011-09-21" version="1">MSRITTKILKMIIFLGIFAWYVYSQFQKGGAIFSLEIIGAGLGLASLAYISLSLYGFILDVSKRYLLAFIITVAIALFVSFKIDGIIASIPWLSEDGFVFIIIVLTVLCVVRDVKTIRTISQIQKSSVTQTNSTDERNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHB8</accession>
    <name>F7KHB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005335851.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05257"/>
    <dbReference type="EnsemblBacteria" id="EGN33290">
        <property type="protein sequence ID" value="EGN33290"/>
        <property type="gene ID" value="HMPREF0994_05257"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5743"/>
    <dbReference type="eggNOG" id="ENOG5031RWJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179097_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="102" mass="11634" checksum="8C3A9CEEDC9DB4EC" modified="2011-09-21" version="1">MTRLTKIEKETIVLFNEGEDKANIYTHNAGLKKRLAAFAKKYPDLCRLEKSNVQGGVSYELAKSRLSIRFLPPYSEERRQKASEYAKKHGLNSQQGQCDNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHR8</accession>
    <name>F7KHR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255250.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05407"/>
    <dbReference type="EnsemblBacteria" id="EGN32848">
        <property type="protein sequence ID" value="EGN32848"/>
        <property type="gene ID" value="HMPREF0994_05407"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5910"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364053" evidence="1">
        <location>
            <begin position="30"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="441" mass="47883" checksum="455421F60EB46DA1" modified="2011-09-21" version="1">MKKKAVSILLSLIMAASLLAGCGTKDSVSDSGNSQSGQSSQSSSAEEKTLTFWSIATESDNMHSSYLKAIEEWESNHEGYKIKFETFENQAYKTKIKSAVAANELPDLFFTFGGGFSQPFAESGKVLPLDDYYANYKDQLPEAALKNQTYDGKIYGSTFTTPVSVMFYNKKIFEENNLAVPTTYDELLAAVNTLKAAGITPISTSVKDTWVLGMLHDGLTLKSAGPTKLQNALLKQEGQSYNDPDMLQSAKAIVELNEAGAFEEGATGLSNDEAVQPFLDGQAAMFFTGSWLGGDINTRSYDKEAFGVAPIPVVNSDNATLGDFMGGASDTIMVAKSTKYPEVACDAAFEIAKYISKNAYLEGVAIPAWNIDYDDSAVEPMTKEIAGYTTKANSFTLWFDTLLPAEDANKYLELLQQLYSGGITPEDYVKAMADQLDSTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIZ5</accession>
    <name>F7KIZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255600.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05824"/>
    <dbReference type="EnsemblBacteria" id="EGN31900">
        <property type="protein sequence ID" value="EGN31900"/>
        <property type="gene ID" value="HMPREF0994_05824"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6371"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="29556" checksum="1570A958150539D4" modified="2011-09-21" version="1">MKLVSWNVNGLRACMGKGFMDFFKEADADIFCIQESKLQEGQISLELPGYHQYWNYAVKKGYSGTAIFTKEEPLSVSYGLGLEEHDQEGRVITLEFPDFYMVTVYTPNSQDGLARLDYRMTWEEEFLKYLKKLEEKKPVIFCGDLNVAHKEIDLKNPKTNRKNAGFTDEEREKFSVLLENGFIDTFRYFYPDLKDAYSWWSYRFHAREKNAGWRIDYFLVSPQLKERLEDAVIYKDVFGSDHCPVALILKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ62</accession>
    <name>F7KJ62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255670.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05894"/>
    <dbReference type="EnsemblBacteria" id="EGN31522">
        <property type="protein sequence ID" value="EGN31522"/>
        <property type="gene ID" value="HMPREF0994_05894"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6447"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="32951" checksum="251BA9EB1805EEBD" modified="2011-09-21" version="1">MEKKVKMSKKDTVFMGLVYLFLTFVLIIVLYPLIYVISASFSSPGAVSSGKVFLLPVDPTLIGYDAVFKNPKIVSGFLNSFFYLIIGTAVNVAMTMLAAYPLSRREFLGRKIISGIFVFTMYFSGGLVPTYLLVKNLHLLDTRAAVIIPVAMSVWNVIIARTYLQSTIPDELYEAAQLDGCSVTGFLVKIVLPLSAPILAVLVLYYGVGNWNSYFNAMIYLKSQELYPLQLVLREILMLGKVDMTMITDVNALQRMQGLSSLLKYAVIVVASLPMMAIYPFVQKHFVKGIMIGSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJD5</accession>
    <name>F7KJD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255720.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05944"/>
    <dbReference type="EnsemblBacteria" id="EGN31572">
        <property type="protein sequence ID" value="EGN31572"/>
        <property type="gene ID" value="HMPREF0994_05944"/>
    </dbReference>
    <dbReference type="GeneID" id="29729585"/>
    <dbReference type="eggNOG" id="ENOG50331G5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989664_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357495" evidence="1">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="30370" checksum="48AF324909FA4B3C" modified="2011-09-21" version="1">MKKKFSLLALALASCVTALAGNPLTSQAAEIPQLGPSRIWGTMTKAGNDTIIFDNQSGESYQGDIVIHISEDTKILDAQNGFPVSPDSIQDGQTAYAYVGPAMTMSIPPQTNSPMILTEIPADYKVPDYVAVKSMEDKGAAYLLTAADGSEFTVPKDCTIIPYLTRNMVFLTDLTEGRTCLIWSDAASSAYKIVLFAQNADDGDKPADGAETVLPAYGWFEEDGLIYFRNEDGSLVKGFIQVGEQIFFLNTETGAMQTGLITIGDTTFNMFADGTFRIETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJW1</accession>
    <name>F7KJW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255916.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06140"/>
    <dbReference type="EnsemblBacteria" id="EGN30766">
        <property type="protein sequence ID" value="EGN30766"/>
        <property type="gene ID" value="HMPREF0994_06140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6725"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="287" mass="31749" checksum="AAFA01CE67888401" modified="2011-09-21" version="1">MKKKTWGIHTFMAIPAFLLFAVFFLYPLGRGLQMSLTNWDGIGKAEFIGLGNFRSFFSDKRAMGDIRNTLLFALGSAPLLNIVGLGYALLMNGRFRGKSLARMFIYMPAIISPLIMGYIWYLLLQPGRGFLFHLLDKMGKGAWFGNWLGSFGSAMLVLILVNVWQYAGMTMVIYLAGLQSIPTELYEAGKMDGASGISAFRYITIPLLGPSIRINVITNIIGSLSVFDIVMSLTGGGPGYQTETLSIYIMRMCYGSKTGYSTAVAVIMFFIILIPVLAALRLTREKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJY9</accession>
    <name>F7KJY9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06178"/>
    <dbReference type="EnsemblBacteria" id="EGN30671">
        <property type="protein sequence ID" value="EGN30671"/>
        <property type="gene ID" value="HMPREF0994_06178"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6765"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020211_14_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="341"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="446" mass="51439" checksum="31D74614F1540996" modified="2011-09-21" version="1">MMKLIDILMILLFPLLDSLPFALPRYWLFRDRLRLPFRYIVLLQSILAAIYSVVFYAINRGGYAAAEQWTTITRYSFLLVYLILAFLLIRDSFSKLMFTWLLFLAWQFFVLGNANFIESRFFWDFSDQHPYLVYNAARIVIYLITCPFLFHFFSHTIADALKINDKAMWKNFWKIPLFSTLFGMLYCTVTDVYAYASWQFLVSRYLMLFGACYVSFVTLQVLEVSRTRTQLEEELKYADRSLQAQKKQFDGLAAHMDEMRRVRHDLRQHLAVVQSYIDRDDKAGLADYIDLYKSQMPPDTRERYCRNDVVNAIICYYASLARDSGIEFEAGVDYPDDCPVSDTDITVLLGNLLENAVEACRQEAVERRLITLRVKRRGSSSLLILVDNTCVTPVMFANGMPLSSKKEGGGIGTASVSEIAARYGGTVQFEQNSEVFYASVILHVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK74</accession>
    <name>F7KK74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256029.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06253"/>
    <dbReference type="EnsemblBacteria" id="EGN30522">
        <property type="protein sequence ID" value="EGN30522"/>
        <property type="gene ID" value="HMPREF0994_06253"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6851"/>
    <dbReference type="eggNOG" id="ENOG5032UAU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101764_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032479">
        <property type="entry name" value="DUF5058"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16481">
        <property type="entry name" value="DUF5058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="246" mass="25991" checksum="D81B781F29193B14" modified="2011-09-21" version="1">MNNEYIASVNSGVFYLIVACVLLFITVMCFVYLIKSYRAGLAIGMDKKVLKRAIISSATFTILPSISILLGVIALSGTLGVPFSWLRLSVIGALQYELNVAEIAAQSIGLSGLKLSEMSMSAFATISLVMTIGILGGVFCCIFFLKKYLGKIQKAPKAKGDSKPGFGDHATTCMFVGLCGAYIGSYVGTFTSTGNYVPLAVAAVSAAFMAVFEYFTNKKGMAVLDNFSMAVSMLAGMAAAVIMSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKC0</accession>
    <name>F7KKC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycyl-radical enzyme activating protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_06299</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256069.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06299"/>
    <dbReference type="EnsemblBacteria" id="EGN30218">
        <property type="protein sequence ID" value="EGN30218"/>
        <property type="gene ID" value="HMPREF0994_06299"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6903"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058969_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040074">
        <property type="entry name" value="BssD/PflA/YjjW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01118">
        <property type="entry name" value="activating_enzymes__group_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN30218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="34430" checksum="32562661DDC7845B" modified="2011-09-21" version="1">MCLDNKQTTAVIFNIQRFSVFDGPGVRTAVFFKGCNLRCRWCHNPESYEKRPQLAFDKQKCIGCGSCVENCPGGCLLPDPGRGLVYDRKNCRDCGQCARGCYARALSRIGYEITAEELMDELLEELPYYRESGGGVTFSGGECMLQLDFLEEVLRCLKEKGIHTAVDTAGNVPFEDFERILPYTDLFLYDMKAFHEEVHRELTGVSNERIKDNLVRLAQAGKDIRIRIPVVEELNASELPFMKRFLWDNGIRDIELLAYHRMGVGKGDLLLEPIVQESFRELGAEEMEEYNSSSDRAAHLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKD2</accession>
    <name>F7KKD2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06311"/>
    <dbReference type="EnsemblBacteria" id="EGN30179">
        <property type="protein sequence ID" value="EGN30179"/>
        <property type="gene ID" value="HMPREF0994_06311"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6914"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868147_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN30179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="320" mass="37159" checksum="EB37FE07405E0AB5" modified="2011-09-21" version="1">MCKIWTFFLKLPFRPVIMVLMNTQEYLIQSSYITTRTSLPLFTEEYHYSRHPKEAAHSHEFLEIGIILSGQVIHHTKEESSLLTPGCVYCIPIGQKHALESDREFTIRNLYLLPKILLTEASGENTPILLQDFFLYYTEYRKKQITYNTLSPDLLSSVRMLFQSYDNTPLCDPLLDSFRYHCLFNILLILCSSFYSANQAHFARKDDRIYQILGLIRDNLSLPTGSLLGLIADELSLNPQYINRLTKKELHTNLSTLILDTKIEKSCELLLKEYTVTEVANALAFYDHAHFYKAFQRKLGITPSRYQRKNKAFRFGDGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKQ4</accession>
    <name>F7KKQ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256195.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06433"/>
    <dbReference type="EnsemblBacteria" id="EGN47568">
        <property type="protein sequence ID" value="EGN47568"/>
        <property type="gene ID" value="HMPREF0994_06433"/>
    </dbReference>
    <dbReference type="GeneID" id="29727839"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784790_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="166"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="353" mass="39912" checksum="91121F174AD1833F" modified="2011-09-21" version="1">MFGLEDMKKIVYGGLVREKETGAFSFSRMTEKQYGYFTREEDARFLVRMGCTAGICMDFYTDSGSLEFDYEISGMADRDIVQLDICQNGVRTGGPAQKPGKDTVGSIRHRIDRDGHRWNRITVWFPYMSSIALKNISLAPGASLCTLEEGTPDGDFPGRIRKKLLCYGDSITQGYDALHPSQGYAVRLARYFDWELWNAGLSGYIFDAGLLDEKLPFQPDIVTVAFGTNDWNWAESKEEAVRNAERYFDKIMELYPGRPIFYFSPLWRGDTGVPTKAGEFRPFCLALLNAAKERGIETIDGYLAAPHKEDALADGILHPNDEGMACYSEYAAKIFMKYGLTEDFWPGCFACRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKW5</accession>
    <name>F7KKW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06494"/>
    <dbReference type="EnsemblBacteria" id="EGN47505">
        <property type="protein sequence ID" value="EGN47505"/>
        <property type="gene ID" value="HMPREF0994_06494"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7110"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="312" mass="35250" checksum="2AF3AD25D2BC74EC" modified="2011-09-21" version="1">MVKNSADRRKKAAKTLKLMWNLKWIYLMLLPVVAYYIIFKYIPMYGVTIAFKDYNVFKGMLESPWVGFKVFEKIFASKNFWHSVKNTLVLNLLTLAVNFPLTIFVALMLNEVIHLRFKKMIQSILYLPHFISWVVVAGIAANMFTQRDGTINLVLNSLGISSIPFLSDEKWWIVTYVICSVWKEIGWGTIIYLAALTGVDESLYEAAYLDGASKLQRLIYVTLPSIKSVVVTMLILQVSKMMTIGLDAPLLLGNDKVMAVSEVISTYVYRIGIENAKYSDSTAIGLFQSVVNILILLAADRFAKAIGEEGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL07</accession>
    <name>F7KL07_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256298.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06536"/>
    <dbReference type="EnsemblBacteria" id="EGN47255">
        <property type="protein sequence ID" value="EGN47255"/>
        <property type="gene ID" value="HMPREF0994_06536"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7158"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="146" mass="16284" checksum="3F2F2C1295E345C5" modified="2011-09-21" version="1">MDKTDSTILSILKENSRASASDISKQVSLSVPAVTERIRKLEQTGVIEKYTIRVNPGASGYNLLAFILVKMDYSRNMEAFQDVCLQLPQVLECHHTAGPADFLLKVLFRDMQDIEDFLSCTLKDIKGVTDANTIICLSTLKEEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRL2</accession>
    <name>S2KRL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_07233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360191.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07233"/>
    <dbReference type="EnsemblBacteria" id="EPC05084">
        <property type="protein sequence ID" value="EPC05084"/>
        <property type="gene ID" value="HMPREF0994_07233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="299"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="500" mass="57213" checksum="89A9F05DA790420E" modified="2013-09-18" version="1">MAKLVINAWDRKSKISRELYGQFSEHLGRGIYEGIYVGEASDIRNVKGMRCDVVEALQQIQLPVLRWPGGCFADYYHWKDGIGPREKRKKIVNANWGDVVEDNSFGTHEFMELCEQIGCEPYICGNVGSGTVEEMSDWIEYLTFDGSSPMSELRAENGHPEAWHVKYWGVGNENWGCGGNMTPEQYGQEFRRYRTFCRNYGDNRLYCIAGGADVADYQWTEGVMKTAAYTGNRRLMDGISLHYYTQPNTWEHKKRATEFELPDYYRGFVRALRMDELIEKHCEIMSRYDPAHEVGLVVDEWGAWYEVEEGTHPAFLYQQGTVRDALLAAVQLDIFNKHSDRVKMANLAQMVNVIHSIILTEGRHMILTPTYYVFELYKGHQDASLLGSWLETEEIGDEESRIPSLSHTASIKDGELHLTVSNLSPFRSEEIDCYLLGYTPEIMEGRILQGDMAAHNTFDNPENIKLNELQEIKRKDGGISFILPACSVAEIILKENSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS72</accession>
    <name>S2KS72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_07192</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07192"/>
    <dbReference type="EnsemblBacteria" id="EPC05137">
        <property type="protein sequence ID" value="EPC05137"/>
        <property type="gene ID" value="HMPREF0994_07192"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021577_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="10">
        <location>
            <begin position="586"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EPC05137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="635" mass="68181" checksum="77E14260A31330E2" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS79</accession>
    <name>S2KS79_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359724.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06967"/>
    <dbReference type="EnsemblBacteria" id="EPC05299">
        <property type="protein sequence ID" value="EPC05299"/>
        <property type="gene ID" value="HMPREF0994_06967"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="329"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="607" mass="69264" checksum="AF0C2B32BBD13A60" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSE1</accession>
    <name>S2KSE1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_07062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07062"/>
    <dbReference type="EnsemblBacteria" id="EPC05394">
        <property type="protein sequence ID" value="EPC05394"/>
        <property type="gene ID" value="HMPREF0994_07062"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="26302" checksum="41FA9EA561E6D5D7" modified="2013-09-18" version="1">MNIHVFFIVCPMVFLAGIVDSIAGGGGLISLPAYLMAGLPPHMAVATNKLSSSCGTTVSAFRYLKNRCVSLPLVPSTVLAALAGSAIGAHLVLALDERYIKGMLFIVLPVTAFFVLRKKSPLDTQGPALPLKKQLLIATLAAFIIGAYDGFYGPGTGTFLVLILTGLARMDVRTASGNTKCINLASNIAALVTFLINGQVFLLLGLCAALFSILGNFIGSGMVVKNGAKTVRPIIIVVLILLFFKLLTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSS9</accession>
    <name>S2KSS9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06975"/>
    <dbReference type="EnsemblBacteria" id="EPC05307">
        <property type="protein sequence ID" value="EPC05307"/>
        <property type="gene ID" value="HMPREF0994_06975"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="351" mass="40812" checksum="B9EB434DDD5E4A76" modified="2013-09-18" version="1">MKKYKVLMCGSDFSVGGGMIAVAKNYLDYKGLKNIEFIYVPTHIEGNVIKRSLIFIKGYLTVLDLLIKKRIDLAHLHTTENGSFFRKGIILRTLKKFKIPTIMHHHIDYQLFYESCNDIKQKFIRDTFSIADMNIMLGECYCNWVIEKSPNARVCKIYNAVNSYDINKYNPDGNLIMFLGWLIDRKGIYEFLQAIKNLDDKLDNKYKVVLCGDGKDKIEPVIEQLRIKHRIVHIGWADLKTKERFFSETVINVLPSWREGLPMTILETMAYGIPNVVTNISIMSEVISNDKIGTVVQTKNVEQLTEAIYRIINDRNLRLVQSENSYNLIKNKFDILNHIKQIEEIYLDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>S2KT08</accession>
    <name>S2KT08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359896.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07065"/>
    <dbReference type="EnsemblBacteria" id="EPC05397">
        <property type="protein sequence ID" value="EPC05397"/>
        <property type="gene ID" value="HMPREF0994_07065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012770">
        <property type="entry name" value="TreR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02404">
        <property type="entry name" value="trehalos_R_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="28442" checksum="D7DE4A61C2862FC8" modified="2013-09-18" version="1">MPKAKYESIYKDLKQKIESQEYPCQELLPSENTMVEIYGCSRNTIRRAVAQLVEEGYVQSLHGKGVRVIYQPVDQASFYIGGIESFRESAERNHRQTSTHVVQFAEISADEHIHTKTGFPTGSILYYIQRVRYLDGKALILDINMFLKSQVPGLTPEIAEGSIYDYIEKKLGMQIITSKRTMTVEHTTQVDEKYLELKDYNCLAVVTNQTYNADGIMFEYTQSRHRPDFFRFQETATRKHRQETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>S2KW56</accession>
    <name>S2KW56_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">HMPREF0994_07123</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EPC05230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360004.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07123"/>
    <dbReference type="EnsemblBacteria" id="EPC05230">
        <property type="protein sequence ID" value="EPC05230"/>
        <property type="gene ID" value="HMPREF0994_07123"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="258"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="374"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EPC05230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="449" mass="48771" checksum="A9CC5EA0FD11F7A5" modified="2013-09-18" version="1">MARLFGTDGVRGVANEELTPLLAMQLGQAGATVLTKENEHRPTIMVGCDTRISGDMLANALMAGICSVGANAVYVGVIPTPAVAYLTKKYKVEAGVVISASHNPVEFNGIKFFDGNGYKLPDSMEDEIEALIRNGMQGVEMPTGSRVGKIKYRTDAREEYINHAIQSVPVDLSGLKIVVDCAEGASFYTSVEALRELGANVVPIHNMPDGTNINSNCGSTHMEELQARVVYEKANVGLAFDGDADRLLAVDENGAIVDGDQIMAVVGNHMRNQGKLKKDTIVATVMSNLGFFQMGEREKLHMEQTKVGDRYVLERMREIGASLGGEQSGHVIFLDENTTGDGLLSALHLLEVMVDTGKPLSELASIMTVMPQALVNARVPNHKKDKYMEYPEIAGAIDELNRKFAGDGRVLIRPSGTEPKVRVMIEGRDQKMIDEEAHKLADLIQNIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJV4</accession>
    <name>S2LJV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Azaleucine resistance protein AzlC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_07134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EPC05223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360028.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05223">
        <property type="protein sequence ID" value="EPC05223"/>
        <property type="gene ID" value="HMPREF0994_07134"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065777_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EPC05223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="230" mass="25686" checksum="2438AC972DCC037B" modified="2013-09-18" version="1">MKRKALKAAIPYTLPVMMGYLFLGMAFGILLTSKGIFYGWALFMSLFVYAGSMQFVAIELLLTPFAPLSAALVTLMVNARHLFYGLSMLEPFKIMGKLKPYMIFSLSDETYSLECSAKPPEGVERKYFLFFIALLDQSYWVIGTLAGVLAGNIFPLDSTGIDFAMTALFLVIFLEQWESTSNHIPALAGLVITFLCLITAGHDNFLLFSMAGILVFLILFRKQCTKERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>S2LK45</accession>
    <name>S2LK45_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WecB/TagA/CpsF family glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06976"/>
    <dbReference type="EnsemblBacteria" id="EPC05308">
        <property type="protein sequence ID" value="EPC05308"/>
        <property type="gene ID" value="HMPREF0994_06976"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="30561" checksum="6F73277FE27C4E09" modified="2013-09-18" version="1">MVAKKIDTNRISFLNTYIDNLTASEAINVVDQYIRERGVHYIVTPNTDIVIKMQEDKELKNICNHADLILADGQIIVKLSKWLGHPIKERVCMTDFIWDVCNLANEKGYRIFLFGGKDNVLEKATQNIKHRYPYLDVVDSYSPPFGFEKDKQLLEEANRRIANRGADILIVFLGCPKQEKFIYQNKDKYNVPVSFTMGGCVDFLGGSVKRAPKWMQNAGLEWFFRFLQEPKRMFRRYFIDDIKIFGLAWQYRRRRKNEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>S2LKA9</accession>
    <name>S2LKA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07056"/>
    <dbReference type="EnsemblBacteria" id="EPC05388">
        <property type="protein sequence ID" value="EPC05388"/>
        <property type="gene ID" value="HMPREF0994_07056"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033CWD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820635_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004498818" evidence="1">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="313" mass="36052" checksum="27D67697DE747FCB" modified="2013-09-18" version="1">MRKSKSTAVFGLCAVLIGSVFITGCSSESTNNRKAVTLKWNQEMEETESAVESTEEEDNSAFNWEILQKMKELNENGEYLDAVKAAQDMDKMSDYSPEIAALRNQIIRENREYFETQIDPAFENGDYYLIGALSNLFLFDKEKKTEYDFVKKLQGEYVLSAEPDGVICVIISGYEIQINGRKSKFSYKRIKPFEQIDYYENRLFLEDGTKVEEVNVGVIAVTYKNKMCIKYTIAGEKENTDKTEKESEAEKEKEYSENEPCIGMTKGEVLNSDWGMPTEINKTTYEWGVSEQWVYPDNKYIYIEEDVVIAITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2J5</accession>
    <name>F7K2J5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250023.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00074"/>
    <dbReference type="EnsemblBacteria" id="EGN48307">
        <property type="protein sequence ID" value="EGN48307"/>
        <property type="gene ID" value="HMPREF0994_00074"/>
    </dbReference>
    <dbReference type="GeneID" id="29724264"/>
    <dbReference type="eggNOG" id="ENOG50339R2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2450790_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="89" mass="9753" checksum="9A090115CFA84EFA" modified="2011-09-21" version="1">MTEERFEQVIENAIEGAADKFDHSINRAWKHRPVRIIGKSIACLSGVGLLAASLPLFEKGQNTAAKVCLISGGIVIACNAIELFIFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V9</accession>
    <name>F7K2V9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250137.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00188"/>
    <dbReference type="EnsemblBacteria" id="EGN40745">
        <property type="protein sequence ID" value="EGN40745"/>
        <property type="gene ID" value="HMPREF0994_00188"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.200"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="454" mass="48394" checksum="BB6A56D9F375C7A2" modified="2011-09-21" version="1">MENKEQNLTVGSVPQKLIRFALPLFGANLLQSLYSIIDMLVVGRIVGKNGLAAISNASMIGFIINSICIGVTMGGTVLAAQYKGADDEQGQKETIGTLFSLSFLAAILVTAAGLLLYAPLFSLLHVPVEAMKDACSYMEIICMGTIFVFGYNAVCSLMKGLGDSKSPLFFVAAAALVNIVLDLLLVGPLGMGTKGAAYATIFSQGVSLIISVVHLKRKRFLFDFKLKSFVIRKDKLLIILKVGLPTAVQMAVVNISYLIITGMLNTFGVSVAAASGIGLKINTFAGMPCWAVGQAVTTMVGQNMGAQNIERVKKTTQIGLLINVCVTVFAVVLVQIFSENLILLFDPAGTEVIREGVMYLRICCSVNSLVYAVMYTFDSFAIGAGAANVAMCNALLDAVVVRLPVCWLLAFPLQIGFTGIYIGQAISPVLPAIAGLVYFAGEKWYSNKLISNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K316</accession>
    <name>F7K316_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD+ diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250194.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00245"/>
    <dbReference type="EnsemblBacteria" id="EGN37884">
        <property type="protein sequence ID" value="EGN37884"/>
        <property type="gene ID" value="HMPREF0994_00245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.266"/>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132589_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="174" mass="19673" checksum="69A87D53C487EBED" modified="2011-09-21" version="1">MKFTYCPDCGTKLIQKEIGDEGLMPYCENCKKPLFDMFSTCIIALVVNEYGEAALLRQGYISHQYYNLVSGYMKPGETAEYTAAREVEEEIGVPVEKLRFVGTYWFGKKDMLMIGFIAEAKKRELKLSGEVDAAEWVDASRAIDMVHPGGSVSYALLEYYLKEQESIRQKGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K394</accession>
    <name>F7K394_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250272.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00323"/>
    <dbReference type="EnsemblBacteria" id="EGN33464">
        <property type="protein sequence ID" value="EGN33464"/>
        <property type="gene ID" value="HMPREF0994_00323"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.347"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092732_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="204" mass="23574" checksum="8EF34C0872E47EF9" modified="2011-09-21" version="1">MEFNEKLQLLRKQNNMTQEQLAEKLYVSRTAVSKWESGKGYPNIESLKSISRLFSVTIDDLLSGEELISLAADENLANMNKFFTLIYAILDFMMLVFLFLPLYGQQNENMIRMVSLFSNPDANVLTWTIYFIFPILMAIMGIVQLIASYFSYEKGTRIMRNCSVFLQAFSIIVFTATRQPYATVLLFLFFMIKVILLIKSSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3M1</accession>
    <name>F7K3M1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31965.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00450"/>
    <dbReference type="EnsemblBacteria" id="EGN31965">
        <property type="protein sequence ID" value="EGN31965"/>
        <property type="gene ID" value="HMPREF0994_00450"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31965.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="298" mass="31859" checksum="2E5BB57A88CC933C" modified="2013-09-18" version="2">MAKTAAVGCPAEEKGRRKKESQFSQVLGRLRSNKMAMFGLAISLLLIVLAIAAPLIMPYKYDQMDMANRFASPSLKHLCGTDEMGRDIFSRLLYGGRASLLLGFTATIISTFLGMLIGSVVGYFGGTVDTIVMRLIDILQAIPGILLAIAISACLGSGLFNTVLALSIGGIPMTVRLLRGSIMGVRKMEYIEAAQKINCSVPRTITKHILPNSISPIIVSVTMGIGNTILMAASLSYIGLGIQPPTPEWGAMLTAANQYMVDHPHMVVFPGIAIALIVLSLNLLGDGLRDALDPKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3T5</accession>
    <name>F7K3T5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250463.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00514"/>
    <dbReference type="EnsemblBacteria" id="EGN45518">
        <property type="protein sequence ID" value="EGN45518"/>
        <property type="gene ID" value="HMPREF0994_00514"/>
    </dbReference>
    <dbReference type="GeneID" id="29723645"/>
    <dbReference type="eggNOG" id="ENOG5032UR1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123730_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN45518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="179" mass="18461" checksum="D695009606F13757" modified="2011-09-21" version="1">MEQNKRIIRITRTAVFLALLIVLQAATAPLGSTLLTGSVVNFLLITSVMLCGPASGFTVAVLSPVLARFLGIGPLWALIPFIIAGNITICAVWYLIAGRGGRAGAFRKCLAVAGGAAAKTAVLYGGIACFAVPYLLVLAEPQASLVSGMFSLPQFFTAMAGGTAAAVLLPVLRKAVKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3X2</accession>
    <name>F7K3X2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250500.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00551"/>
    <dbReference type="EnsemblBacteria" id="EGN44739">
        <property type="protein sequence ID" value="EGN44739"/>
        <property type="gene ID" value="HMPREF0994_00551"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="178"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="255" mass="27880" checksum="615DF854C2CAE8D7" modified="2011-09-21" version="1">MNTAFYTAVSGMRTFQSALDITANNMANVNTTAYKAERGAFQDLLYTQMDVKSGELLTGHGVKMSDVQPVFIQGAFEKSGQPLDFAITGDGFFAVEKGNGGTQPLYTRDGSFKISVSEEGDFLATRDGYFVLDGDGKRIQLTKKVVKDKDGKEQATNQLDLDGLNKKIGLFTCDNPEGLVHMGNNRYRSGEFSGQWTAVKEQTNSSRIVSGALELSGTELSSEMVNVIEAQRAFQLNGRIVTTADQIEEIINNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K423</accession>
    <name>F7K423_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00614"/>
    <dbReference type="EnsemblBacteria" id="EGN44802">
        <property type="protein sequence ID" value="EGN44802"/>
        <property type="gene ID" value="HMPREF0994_00614"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.667"/>
    <dbReference type="eggNOG" id="ENOG5032Y5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145226_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013367">
        <property type="entry name" value="Flagellar_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12611">
        <property type="entry name" value="Flagellar_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02530">
        <property type="entry name" value="flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="13914" checksum="E4983AE38E50EABF" modified="2011-09-21" version="1">MDGLHSVSGIGELRLKHDAQLVQKDPSSSFADMLRDRLNQEGSVRFSRHAAERIAQRGADISEGLLENLNKAVETARDKGARDTVIISRDDVFIVNIPHNVVVTMVPYQEMKENIFTNIDSAVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K457</accession>
    <name>F7K457_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250597.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00648"/>
    <dbReference type="EnsemblBacteria" id="EGN44836">
        <property type="protein sequence ID" value="EGN44836"/>
        <property type="gene ID" value="HMPREF0994_00648"/>
    </dbReference>
    <dbReference type="GeneID" id="29725238"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1213575_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="228" mass="24007" checksum="F0A04998CBECAC9C" modified="2011-09-21" version="1">MVKKNEGNLKKAMNELLGIDGAEKRSEVQAGGAEERKVEAEPEREPDSPVSEEPEQRVQVPSAAGADMASGRGTQVRAESFAMPVMDTPKMESVITSDVIIEGNVRSGSNLKILGEIVGDVACEGQITLTGNITGDVRASSLRFNSGNIQGNVTVVNDVTVEKQSHIKGDITAGSLIFNGSAEGNLMISQNMELRESSVVIGNVSADCVSMYNGARLKGLLDVGGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4D7</accession>
    <name>F7K4D7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00716"/>
    <dbReference type="EnsemblBacteria" id="EGN44065">
        <property type="protein sequence ID" value="EGN44065"/>
        <property type="gene ID" value="HMPREF0994_00716"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.775"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760286_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="364" mass="42118" checksum="463C9BC436F75742" modified="2011-09-21" version="1">MEIIEVSDRTPELMEQLLIIWENSVKETHLFLSEAEIADIRKYVPQALAGVPHLIVAKDDANEPIAFMGIDNQRLEMLFVSPQLRGRGVGKKLIHYGIKEYAVNEVTVNEQNPQATGFYEHIGFRVYRKTDMDEQGKPYPLLYMKLYMDSETAGKKRKKAVTAVFIVAAAVVVGVAVAVVFLISLFTEKNVVTDIREYEKYFGPQGIHQSKNTDAWEKTRESYLVLNYIFPEKLPESADVEAFYYEYYNPWDPCYLCYLVYSCDEEDYKAETERLRQISMPKDYLIYGSTGFPYPLLAVDSSSYGYIYAMTDEAQNKIIYVELTFCNYFTDIHYERVIPKEHLPIGFDAKSGNPYREEYLSQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4L3</accession>
    <name>F7K4L3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00792"/>
    <dbReference type="EnsemblBacteria" id="EGN43501">
        <property type="protein sequence ID" value="EGN43501"/>
        <property type="gene ID" value="HMPREF0994_00792"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.861"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599882_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="19210" checksum="F6AA1C107FD63B27" modified="2011-09-21" version="1">MALLEQWRAMAYSETANKADLQRLWAVYFEKEKEIYAQLLKNPDEVVTGTVKELAEKYDVDIMTMTGFLDGIDDSLAESNPIEEMEEDTQVSLGFDKALLYKNMVAAGADWLYELEEWNDIFDEDTRKALYKEQKSSTTIVKDKKVYPNDPCPCGSGKKYKKCCGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4M0</accession>
    <name>F7K4M0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250752.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00803"/>
    <dbReference type="EnsemblBacteria" id="EGN43512">
        <property type="protein sequence ID" value="EGN43512"/>
        <property type="gene ID" value="HMPREF0994_00803"/>
    </dbReference>
    <dbReference type="GeneID" id="29724379"/>
    <dbReference type="eggNOG" id="ENOG5033DGM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313622_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356407" evidence="1">
        <location>
            <begin position="33"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="218" mass="23486" checksum="72BF73D08A8D9BA3" modified="2011-09-21" version="1">MKKKSYTARLGALALALTMVTTCLTGGTMAKYVTTVSATGSATVAKFDVEIKGNDTKFQNNTKIPNLFTTGWNPPVGDGVKPEMLAPGVYGYFDIVVTNSSDVLIKVSDVSITPETKGVSDGKKIRMKYAISDATSVDKPSVFDLEIENLGIKIKDNLGNIGWETDNSKTVRVWWTWENGDVKGDEEDTAIGTYGDNAPTYALTIDITAEQVISTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4V8</accession>
    <name>F7K4V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_00887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43196.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00887"/>
    <dbReference type="EnsemblBacteria" id="EGN43196">
        <property type="protein sequence ID" value="EGN43196"/>
        <property type="gene ID" value="HMPREF0994_00887"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="319"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN43196.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="564" mass="62759" checksum="0B5BC8C7B3AD9A81" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K514</accession>
    <name>F7K514_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-deoxyinosine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250899.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00950"/>
    <dbReference type="EnsemblBacteria" id="EGN43259">
        <property type="protein sequence ID" value="EGN43259"/>
        <property type="gene ID" value="HMPREF0994_00950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1038"/>
    <dbReference type="eggNOG" id="COG3663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094865_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="13"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="182" mass="20869" checksum="AEE719D14082A013" modified="2011-09-21" version="1">MEHVSHEFEPVWNKDSRVLVLGTFPSVKSRQQKFYYGHPQNRFWKVTAALLGRRVPDTVEEKKRMLLEGHIAVWDVIDSCDIEGSSDSSIRNVKANDIGGLLGRTSIQAVFANGDKAYQLYLKYCREQAGMDIIKLPSTSPANAAWSLERLTEAWRVMERFLQTESEYKVKEYGHGTNDDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K558</accession>
    <name>F7K558_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250945.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00996"/>
    <dbReference type="EnsemblBacteria" id="EGN43305">
        <property type="protein sequence ID" value="EGN43305"/>
        <property type="gene ID" value="HMPREF0994_00996"/>
    </dbReference>
    <dbReference type="GeneID" id="29724698"/>
    <dbReference type="HOGENOM" id="CLU_1146041_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="242" mass="26903" checksum="965FEBBB38A7172B" modified="2011-09-21" version="1">MAITLHYRLDDKQNLAVRAETQITYEKDKIYRLVLIILKKDDKNPVLMNDVLLQNGMGSAEVSYDYSLFNSKGVSLTLHAHVCILPDPPPPESTAPEQDITGNTPKPIIVEEQTEDIHLFGTADCLDNIRLEQTQSFLCPAIGPLPAPQARFLIQVQLKEDYTLLRFYKDSVSLTCLTKEGQKKPNYKMDMAANQISFQADSLTGSLASGFSSVNWKGKGIVYQHSTGLMLALSFTLNSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5V5</accession>
    <name>F7K5V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-methionine transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251183.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01234"/>
    <dbReference type="EnsemblBacteria" id="EGN42481">
        <property type="protein sequence ID" value="EGN42481"/>
        <property type="gene ID" value="HMPREF0994_01234"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1348"/>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="221" mass="23361" checksum="0612802199186998" modified="2011-09-21" version="1">MWNSATIMMIVEGTFATIYMTLVSTLMAYVIGLPAGVALVVTGKEGLKPNKAVNRILDVLVNVMRSIPFLILLILVIPLTRAIVGKSYGPSATIVPLTLAAAPFIARLVESSLLEVDKGVIEAAQSMGAGIPTIVMKVMLLEARSSLLSGLAIALGTILGYSAMAGAVGGGGLGDIAIRYGYNRYQLDIMIVTVILLVALVQIMQAICMRLSRKLDKRITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7K665</accession>
    <name>F7K665_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42207.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359984.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01345"/>
    <dbReference type="EnsemblBacteria" id="EGN42207">
        <property type="protein sequence ID" value="EGN42207"/>
        <property type="gene ID" value="HMPREF0994_01345"/>
    </dbReference>
    <dbReference type="GeneID" id="29723336"/>
    <dbReference type="eggNOG" id="ENOG5030K35">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865417_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42207.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="321" mass="37960" checksum="2B10A919118C3E85" modified="2013-09-18" version="2">MAAKKEIIKIVHCAIMKFKYFINNELIFWLMRPIKKYYIIRRPEPGAGFFSNYFWVLGHIVFARKIGYIPIVDMQNYKTLYSEDMPVLGERNAWNYYFEDVDSICLGEALNSKKYIYSKEKYLTKYCEKYASIPYRYPTEEMINYYAPIIAKYMRIKPDIVRKFQEDWRQKIIEGQDILGVHIRGTDMKNNLGHPMPATVAQYIEITKNILSENSQITMIFLASDEIEVIKSYMKWLEGTHYKLIVNDAFRADKSSEKKLVGIHEMNIVNERSYHKYNLGLEVLNDAWCLAKCDYLLCGHSNITNIAILWNNKKYKKIVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K685</accession>
    <name>F7K685_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251322.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01373"/>
    <dbReference type="EnsemblBacteria" id="EGN42235">
        <property type="protein sequence ID" value="EGN42235"/>
        <property type="gene ID" value="HMPREF0994_01373"/>
    </dbReference>
    <dbReference type="GeneID" id="29725041"/>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008413_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="766" mass="88075" checksum="9F20B8D418DCF3A2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6D6</accession>
    <name>F7K6D6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TDP-4-keto-6-deoxy-D-glucose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251390.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01441"/>
    <dbReference type="EnsemblBacteria" id="EGN41915">
        <property type="protein sequence ID" value="EGN41915"/>
        <property type="gene ID" value="HMPREF0994_01441"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1569"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012749">
        <property type="entry name" value="WecE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02379">
        <property type="entry name" value="ECA_wecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="377" mass="42769" checksum="43837E585B26CA78" modified="2011-09-21" version="1">MIRFNVPPFTGKEMDYIRQAVENQKICGDGEFTRKCSEWIEKKTGTRKCLLTTSCTHATELAALLAQVGPGDEIIMPSFTFVSTADAFVLRGAVPVFVDIRPDTMNIDETLIEAAITEKTKAIVPVHYAGVGCEMDAIMDIARRHKLLVIEDAAQGIMAYYKGKALGAIGDFGCFSFHETKNYSMGEGGALLIQHEKDIEDAEIFREKGTDRSKYFRGQVDKYRWQNYGSSYLPSELNAAYLYAQLEMADVINDERIRIWNQYRNELEGLAGTGKIQLPYVPDYCVQNGHMFYIKTADQEERAALIDFLSENDILAVFHYVPLHSAPAGLKYGRFHGEDRYTTKESERLLRLPMYYGLKEEQVSYISGKVKEFYGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6R5</accession>
    <name>F7K6R5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251526.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01580"/>
    <dbReference type="EnsemblBacteria" id="EGN42054">
        <property type="protein sequence ID" value="EGN42054"/>
        <property type="gene ID" value="HMPREF0994_01580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1727"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090591_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="266" mass="30196" checksum="DE617F5298BFA653" modified="2011-09-21" version="1">MELSIQERLKDLRVERGLTLEQLEEQVNLSKSALGSYEAKDFKDISHYAIIKLAKFYGVTADYLLGLSQTRNHPNADLADLRLSDDMIELLKSGLIDNSLLCELAVHPDFPRLMADLEIYVNGIAGKQVQSANAIVDTMSATIMKQYNPGLSDPQLRQLIAAHIDDDSFCRYVIQQDISKIALDLREAHKEDFFSVPEDNPLEDFLQTAEETASPDSDPEQASLAFICKRLRLNYKKLSEEEKKWLKKISEKSDLLKNPNPQRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6R9</accession>
    <name>F7K6R9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009004402.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01586"/>
    <dbReference type="EnsemblBacteria" id="EGN42060">
        <property type="protein sequence ID" value="EGN42060"/>
        <property type="gene ID" value="HMPREF0994_01586"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1735"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008907">
        <property type="term" value="F:integrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004191">
        <property type="entry name" value="Integrase_Tn916-type_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02920">
        <property type="entry name" value="Integrase_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="SSF54171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="191"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="425" mass="48436" checksum="2D1387DF23DAC79A" modified="2011-09-21" version="1">MSKKERDEKRRDNKGRLLKSGESQRPDGRYAYKYTDTFGEVKFVYSWKLVPTDKIPAGKRPDISLREKIKQIQKDLDDGIDTIGKKMTVCQLYEKYIRQRGNVKRGTHKSRQQLMKLLSDDKLGAASIDSVKLSDAKEWALRMQEKGVAYHTICNGKRSLKAIFYMAVQDDCLRKNPFDFQINEVINDDTVPKVPLTPAQEKELLEFMQNDPVYAKYYDEVLILLETGLRVSELCGLTPADLNFEKRCVNVDHQLLRSTEDGYYIEAPKTDSGYRQVPMSAAAYEAFQRVLHRRKNGKGVVVDGYKGFLFLNRDGLPKAAVHYDAMFQGLAKKFNKFHAEPLPEVMTPHTMRHTFCTRMANAGMNPKALQYIMGHSNIVMTLNYYAHATFHSAQEEMERLQAQAQTAAAVNAQPAPESAQEAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6X9</accession>
    <name>F7K6X9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">murB</name>
        <name evidence="18" type="ORF">HMPREF0994_01646</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01646"/>
    <dbReference type="EnsemblBacteria" id="EGN42120">
        <property type="protein sequence ID" value="EGN42120"/>
        <property type="gene ID" value="HMPREF0994_01646"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1798"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGN42120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="33044" checksum="3E74C4C3F18191B1" modified="2011-09-21" version="1">MSKAFIDFLESIVAAENILLEEPMHKHTTFRVGGPAEVFVTVENKEQLEKIIKYLNLVERPYFILGNGSNLLVGDKGYRGVIIRLGGEFNTLKTEGTLLTAGASVLLSAVAREAMENGLTGMEFASGIPGSIGGGVKMNAGAYDGEMRQIVESVQVMYKDGSILDLDNETMEFGYRNSVIKNRPYVVLQVSLRLQPGNREEILARMNELAARRKEKQPLEFASAGSTFKRPEGYFAGKLIMDSGLRGARIGGAQISEKHCGFVINDGTATAADIAELIQEVSETVKEKFGVTLEPEVILLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K780</accession>
    <name>F7K780_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41747.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01709"/>
    <dbReference type="EnsemblBacteria" id="EGN41747">
        <property type="protein sequence ID" value="EGN41747"/>
        <property type="gene ID" value="HMPREF0994_01709"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="137"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41747.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="36909" checksum="4258BB9470BD14EA" modified="2013-09-18" version="2">MNESDCKFEIIYGLVSKEDNLLSVTILCDIAGVSRSGYYRWAGAADERQRKELKDQADFEIILGAYAKRGYDKGAKSIYMTLIHQNPPIIMNVKKIRRLMKKYGLVCKIRAANPYRRMAKAIKTNHVADNLVKRQFTAYGARRVLLTDITYIPYNGVFCYLSTILDAFTKQILSYVLSESLEVDFVLQTVNRMVEKHGVSLSAEAIIHSDQGCHYTSCSFIQLVKDRGLRQSMSRRGNCWDNAPQESFFGHMKDEVDISRCAVFQEVKTIIDDWLDYYNNERYQWQLAKLSPNEYYQYITTGNYPLRGIINEPEKEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7P4</accession>
    <name>F7K7P4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251851.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01938"/>
    <dbReference type="EnsemblBacteria" id="EGN41343">
        <property type="protein sequence ID" value="EGN41343"/>
        <property type="gene ID" value="HMPREF0994_01938"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="65"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="272" mass="29758" checksum="0B1DD61B312E3F1E" modified="2011-09-21" version="1">MRKAVSIFSRILLGILLLLTLAPFYLLVINSFKGQTEIIKTPFQLAVNWQFMNYAKALPQVVRPMLNSLLVTFAVILITVVVSMLASYAFVRYESFFGKELLYYGIIALLMIPGFVMLIPQFVQITNLGLFNSYWGLILPPAAYQVAMGTFLTRSSMEAISKSLFEAAEIEGAGDMDILLKVVLPLSKPILSTVTIMTGLNAWNNYIWPLVASSGEATQQIAVALTKLIVSVSDGNGVLFAGYIIASLPLVILFCFASKYFVAGITQGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K830</accession>
    <name>F7K830_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02077"/>
    <dbReference type="EnsemblBacteria" id="EGN41482">
        <property type="protein sequence ID" value="EGN41482"/>
        <property type="gene ID" value="HMPREF0994_02077"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="244" mass="27116" checksum="85778323702019D6" modified="2011-09-21" version="1">MGYDGVELAGLCGYSPEQVKKMCEEAGLVPISAHVPLAEMSADPEKTMKDYADMGCRYIAIPYLTEEFRPGAENYKSFKKEASHLGELANANGMTLLYHNHDFEFAKKDGEYLLDIMYHDIPASLLQTEQDTCWVKASGVDPAAYIRKYSGRAPVVHLKDFYKSGNAGVSYELIGLEGEQQEKKEEGTFELRPLGQGMQDIPSILKASEEAGAKWLVVEQDDPTKGLTPIECSRISLQYLKSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K842</accession>
    <name>F7K842_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252002.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02089"/>
    <dbReference type="EnsemblBacteria" id="EGN41494">
        <property type="protein sequence ID" value="EGN41494"/>
        <property type="gene ID" value="HMPREF0994_02089"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2293"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="141"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="371" mass="40505" checksum="ECF64B411082746E" modified="2011-09-21" version="1">MKNGKLQVAVVGCGGIANQKHFPALTSQSDKCEIVAFCDIIEERAKAGAEKFGTPDAKVYTDYNEMMKDEDIDVVHVCTPNNSHCPVTVAAFHAGKHVLCEKPMAATTEDAQKMMDAWKKSGKKFTIGYQNRFRTDARALKRACEEGKLGEIYFAKAHAVRRRAVPTWGVFPDKSKQGGGPLIDIGTHALDITLWCMDNYEPESITGSVFEKLGHLPEAAEGNMFGPWDPQTYEVEDSAFGYIKMKNGAAIFLESAWALNVKDSREAAATLCGTKAGAEMIGGMSQEGYDLVFNETTGGILTEEHISDAGAIAFFEGNSGGSPEVLECKQWLEAIIEDKEPLVKPQQAFVVTQILDTIYKAAETGQEIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K879</accession>
    <name>F7K879_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251765.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01852"/>
    <dbReference type="EnsemblBacteria" id="EGN41257">
        <property type="protein sequence ID" value="EGN41257"/>
        <property type="gene ID" value="HMPREF0994_01852"/>
    </dbReference>
    <dbReference type="GeneID" id="29727497"/>
    <dbReference type="eggNOG" id="ENOG50334ZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887920_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="313" mass="35575" checksum="750CE4EFAEFD68E6" modified="2011-09-21" version="1">MIVKGIGATTHIDKHNCMIAKEALEDAVKDINEGLYAIGVGIEHDSTIMPIGKVISGKMVKLKDGEYGIEIEQELFDEYQVFSDETGEKWYIAKSQRDVRPFADTQAEDIHNIKVSIDPVNFSKTDCENLLNFYEKECLFETEYFMRKSVIPDPEIIFTLVAGTIAAMTGKKITEHLTDDIVKLYELIKKAVLKTVKCCKQSYRPITYVIRENSSYLMELVVVTEIPDILFEALQNEKLSQIEAKIETFTNNFNIEIAKVQCLYNIEGQEWIINYVSTRDGKVIGSEKCYKKTVELARKVGTELPDGHTDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8F7</accession>
    <name>F7K8F7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252050.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02137"/>
    <dbReference type="EnsemblBacteria" id="EGN41044">
        <property type="protein sequence ID" value="EGN41044"/>
        <property type="gene ID" value="HMPREF0994_02137"/>
    </dbReference>
    <dbReference type="GeneID" id="29724780"/>
    <dbReference type="HOGENOM" id="CLU_1832581_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="140" mass="16596" checksum="B42FDF74B0BF2C11" modified="2011-09-21" version="1">MTKDCVKPSVYAGVPCEKISSIDDYYKKRKGLQLDEAEDIFDMYYQKYGNISEIFFLFENAPIEELNEEHVRVLKLADSYQKSVERYEKRESRFSDYSEFVEYCLKEWTNSWCFMIFICAGGECYDASNCIFVFYPIPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8T7</accession>
    <name>F7K8T7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252194.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02293"/>
    <dbReference type="EnsemblBacteria" id="EGN41200">
        <property type="protein sequence ID" value="EGN41200"/>
        <property type="gene ID" value="HMPREF0994_02293"/>
    </dbReference>
    <dbReference type="GeneID" id="29724008"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2502"/>
    <dbReference type="eggNOG" id="ENOG50345KQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092332_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="272" mass="31167" checksum="EF7DE38EF45A1734" modified="2011-09-21" version="1">MNLDYSILISPSALKLNLCSVRSPTLREIDSLPNKFSTYNMYLSMLLLDIDSYYKNLEELGDNYFAGYPESEKQLILKIRDEYEQMPEQDKAHIQALDIFSFDSQIIEQLNQALSFFLCEALSFSQENHAFMVYEKETDTPTGAITPQLLPEIESIILQLNAVSKDAMDTSNAKNKAAAKIIEKLNKRKKGNEKKAKSDPKLELPNIISAVAAYHSSINILNIWDLTVYQVYDLFARMQQNTIFDVLKMSVAAWGNKDNKVDFTQWFDCIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8X5</accession>
    <name>F7K8X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252079.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02166"/>
    <dbReference type="EnsemblBacteria" id="EGN41073">
        <property type="protein sequence ID" value="EGN41073"/>
        <property type="gene ID" value="HMPREF0994_02166"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2371"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="384" mass="41984" checksum="F89FC087F30AB901" modified="2011-09-21" version="1">MASRKNRKQSEYFFDYTLLFIVLFLLGFGLIMVYSTSSYEASISANLKYDEAYYLKHQAFAAVMGFFAMIVVANIPYHFWERFATLGYFVSAILIVLVLTPLGIEANGARRWLNLGLSVQPAEIAKLCMILFLASFICKMGKGIRTGRGFWMVLMIPVPICVMVWKITNNMSSAIIIFGIALLMLFVASPDYKRFVLMGAAGVAAVAALVFAIIQMEHSDLGFRGGRILAWLNPEDYASGTGFQTLQALYAIGSGGIFGKGLGQSMQKLGFLPEAQNDMIFSIICEELGLFGGIAVILLFVLLIWRFMVIANNSSDLFGALLVVGVMGHIAIQVILNIAVVTNTIPNTGISLPFISYGGSSVMFLMVEIGLVLSVAKGIKLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K966</accession>
    <name>F7K966_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252310.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02409"/>
    <dbReference type="EnsemblBacteria" id="EGN40808">
        <property type="protein sequence ID" value="EGN40808"/>
        <property type="gene ID" value="HMPREF0994_02409"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2639"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061731_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="242" mass="28271" checksum="DE194645948020D0" modified="2011-09-21" version="1">MKITYIAHSGFSVELEKQVLLFDYFTGELPVWDKQKTILVFASHRHQDHFNMKIFSLREQYPHIHFFFGNDIKLSRAQMVHKKADPEALEDVTSLKAHESLTYGDGDGAVRIRTLKSTDEGVAFLVEAEGKSIYHAGDLNWWYWEGEPLSWNRNMEVNYKREIDSIAGSFFDAAFVPLDPRLEAAFGYGMDYFLQKTDAAHIFPMHMWEEYGYIAKYRETETGRPYADRIMEIKERGDVFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9C0</accession>
    <name>F7K9C0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40870">
        <property type="protein sequence ID" value="EGN40870"/>
        <property type="gene ID" value="HMPREF0994_02471"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2709"/>
    <dbReference type="eggNOG" id="ENOG5033CCB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205759_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="49" mass="5774" checksum="6983567EDC1121F4" modified="2011-09-21" version="1">MASYVAPEVREKFETLSINLKDYILERNVQINDIYDLINVLENIVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9F7</accession>
    <name>F7K9F7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252418.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40916">
        <property type="protein sequence ID" value="EGN40916"/>
        <property type="gene ID" value="HMPREF0994_02517"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2759"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="456" mass="49140" checksum="0390E1F0E8584F70" modified="2011-09-21" version="1">MTKDMTKGSPFKLIIGFAVPMFLGMLFQQFYSMVDTMIVGKLLGVNPLAGVGSTSSLNFMVIGFCTGVCNGFAIPVAQMFGAKKESDLRKYVANCTWLCAGFSVILTLLVVIFCKPILHLLRTPTEIFEYAYVYIVIIFWGIPCTFLYNILAAIIRSLGDSRTPVVFLAVASILNIILDLVFIIPFHMGVEGAALATVISQGVSGVVCLFYMKKKFAVLKISKAEWRPQPLFMKNLCMVGIPMGLQYSITAIGTLVIQAAVNGLGAAAVAGVTAAQKIYAFVSCPIESLGATMAPYSGQNMGAGKLERLEKGLVAASLTGFVLSGLALVLMWLFGNNMSLLFLDKSETEVMAYSYQFLMTASVGFCLLTLVNTVRFTIQGMGFSGFAMTAGVLEMIARTLAGTVLVPLIGFRGICLAHPLAWLFADVFLIPAFLHCRKKLERMMRGEGAAGASVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9T6</accession>
    <name>F7K9T6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252520.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02619"/>
    <dbReference type="EnsemblBacteria" id="EGN40602">
        <property type="protein sequence ID" value="EGN40602"/>
        <property type="gene ID" value="HMPREF0994_02619"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2871"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="333" mass="37204" checksum="7267B5590827FD3D" modified="2011-09-21" version="1">MEQKKLRVAVIGAGGWGYQHARAFSGRSDTELVAIAGRTQERTAKRAAEFKVPFYLSVPELLEKEKPDFVSLCLPAQHTFETTMAIIEAGIPLLSEKPIAYKLEEARALVAKAEEKNLFYAIDFNQRYSIPCLKAKQAIDEGRLGRPVFAHWRFGHGWDTPYLDHPYLNLIEAQCHGLDLLEHLCGPIRSCMAEMTDNGGRNSFSSFTLALRFQNGAVGSFLATLDANEHNRLSQLVEIGGTDGRILIEDNVRSYSFQSTNSDMAETWQAGFFEDDLRSFGRNLDRHLDALIPALLAGQKPPVPARRGLRALELAYGAIRSFETGQRIEMKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Y9</accession>
    <name>F7K9Y9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_32N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40655.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359733.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02672"/>
    <dbReference type="EnsemblBacteria" id="EGN40655">
        <property type="protein sequence ID" value="EGN40655"/>
        <property type="gene ID" value="HMPREF0994_02672"/>
    </dbReference>
    <dbReference type="GeneID" id="29726676"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645272_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="2">
        <location>
            <begin position="152"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40655.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="425" mass="48011" checksum="ED3F515A66821DA9" modified="2013-09-18" version="2">MERGSRADGKESCSTAWILRFRVPDTEGIFFSMEEEGERFLLEYREGILKAVIRFSARPEPVTLAGTCRPGNEAVLNFTGFRLELLTEGALADEDWTIGRVDIAGICGRGKGLELRPELGRCLIREEREESFTGIQGWKPEGKNVHLGDCMPFYHDGTFHLFYLFDRRGHKSKWGLGAHQWAHVASQDLVHWTQYPLAIGIDDEAEGSICTGSVIFHEGIYYAFYAVRMCDGSPARLTAALSQDGIHFQKSHRVFALQPPYDGASARDPKVIRDENGVFHMFVTTSLLQGEESRGCLAHLISGDLVTWEPVEPLVVLDISDQPECSDYFRLGDFYYLVYSNFGTARYFFSENPFGPWQAPDENVVVERSYRVPKAAGWKDERILFAGFYVDPDVDYGGTVRFYDAAARKDGSLEFLPVPEMVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAB3</accession>
    <name>F7KAB3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PglZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252803.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02902"/>
    <dbReference type="EnsemblBacteria" id="EGN40511">
        <property type="protein sequence ID" value="EGN40511"/>
        <property type="gene ID" value="HMPREF0994_02902"/>
    </dbReference>
    <dbReference type="GeneID" id="29723441"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030086_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PglZ" evidence="1">
        <location>
            <begin position="236"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="484" mass="55611" checksum="941AF0236AC2864D" modified="2011-09-21" version="1">MFGDYVLKQAAAEYNNRILLIDDEGLEELTHYSADFQAHGFEVVHYTDDLTFRIEYEDKLKNTANKLLVLAHSGSYIPYDLQRRLRVYLLSMDRLFPKLNMEALKARRNLDLELLCLAYKKNFDDLRQRKQTEEFLHQKVDCSENVAAYLKQRYSELLQSLTTAKSYRDWFALAETKAKIDTLSTEYRLNFDTSEVNRAFRDYVLKEFGKLSTEMNKETPVLVSRAMEYMNDHSNKFVIIVMDGMSKFDWSIIAKSFHDLQYEQSAAFAMIPSTTSISRQCLLSNKTPGQLMEPWKQSKEKQEFVACARSMGYTDNQIGYERGYDAQFGSFVKCGAVIINDVDDMVHAQHQGRLGMLNDIGVLSDQHKLADMTKRFLSEGFDVYITADHGNTPCTGLGKLMGTGVETETKSRRMIVLQNFADKDGLMQKYGLIEYPKYYMNKAFDYLICDVGDSFDAKGEEVMTHGGITIDEVIVPFIKIKAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAE1</accession>
    <name>F7KAE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RsmD family RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252668.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02767"/>
    <dbReference type="EnsemblBacteria" id="EGN40376">
        <property type="protein sequence ID" value="EGN40376"/>
        <property type="gene ID" value="HMPREF0994_02767"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3026"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="185" mass="20505" checksum="50431A906980EC45" modified="2011-09-21" version="1">MRVIAGEARSLPLKTPEGQDTRPTTDRIKETLFNILQGDIPGSIFVDLCSGSGGIGIEAISRGAKRAYFAENAVKAAKCIQDNLSFAKFTDRAVLLKQDVVSALGGIHEKEVDVIFMDPPYQAGLEEPVLSALSRASYVTEDTLIIIEAELNKDFSFTQDYGFEVIREKKYKTNKHVFMKRQNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAI9</accession>
    <name>F7KAI9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rne/Rng family ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02815"/>
    <dbReference type="EnsemblBacteria" id="EGN40424">
        <property type="protein sequence ID" value="EGN40424"/>
        <property type="gene ID" value="HMPREF0994_02815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3082"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003468_5_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="392" mass="43711" checksum="2843F29AAA09AEE1" modified="2011-09-21" version="1">MEANAYPLPAAGPAEEAEGASGNVSCLLGSIYVGKVNNVVKNINAAFLELTKGQRAFLSLDNRNEPRLLNRPYDGRLLAGDEVLVQVEKEAVKTKDPVVTTELSFSGRYAVLLPTGRPGRLIFSGKLDNSCRKILKGFLEREEIKNVLERSSLIIRTNASELTEGEPLVQDILRLDSLAGQILSVAGTRTCYSCLYRPASAYLTEIRDTYHDQYDAIVTDSPDLYEEARLFLEQQCPGELHKLKLYQDPSVTLMNLYGLSAKLREATETRVWLKSGGYLVIEPTEALTVIDVNSGKYSGKKAIRDTFRLINLEAAAEIARQLRLRNLSGIIIVDFINMEDSADKQELLQALSRELRQDPVKAVVVDMTPLGLVEITRKKIRRPLREQLNETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAM4</accession>
    <name>F7KAM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylated-DNA-protein-cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252751.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02850"/>
    <dbReference type="EnsemblBacteria" id="EGN40459">
        <property type="protein sequence ID" value="EGN40459"/>
        <property type="gene ID" value="HMPREF0994_02850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3118"/>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="117" mass="12937" checksum="8CE5B60F973B6FB4" modified="2011-09-21" version="1">MDFYRRLALAGKAIPFGKVATYGQLALLCGRPRNSRQVGYALNRGLAGEKLPAHRVVNSQGLLTGAPAFDTPDMQKWLLEGEGVEVKDGKVDLKKYGWHNTMEEAMALKECFDRLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB07</accession>
    <name>F7KB07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BMC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252937.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03036"/>
    <dbReference type="EnsemblBacteria" id="EGN40213">
        <property type="protein sequence ID" value="EGN40213"/>
        <property type="gene ID" value="HMPREF0994_03036"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3316"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175373_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="104" mass="11108" checksum="5C70E89A6D3F784C" modified="2011-09-21" version="1">MGEAVGILEVFGLVCAFMAADAGCKAGNVRLEPFDKNKPANADSLPVPLLVTIKFRGSISDVEAAMEAGERMAKSLTGVVQKHIIPRPTEDTEKMLKLCAFDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBK3</accession>
    <name>F7KBK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253140.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03239"/>
    <dbReference type="EnsemblBacteria" id="EGN40069">
        <property type="protein sequence ID" value="EGN40069"/>
        <property type="gene ID" value="HMPREF0994_03239"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3539"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121336_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="172" mass="19491" checksum="E5CD95FDD9D31A4F" modified="2011-09-21" version="1">MKEELRQHEKRLVIHDLPAGAMSAVKDENIIEICDDGSIKSCIGCFGCWLKTPGKCILKDKYNEMGRLLAGSGEIILISRCCFGGPGPFVKNVLDRSISYILPYFVLKNGEMHHRQRYRKTLALRVVFYGEDLTEQEKETAREWVDAMADNLYCEVKQVAFCRNPEEAGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBN8</accession>
    <name>F7KBN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAA_hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253176.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03275"/>
    <dbReference type="EnsemblBacteria" id="EGN40105">
        <property type="protein sequence ID" value="EGN40105"/>
        <property type="gene ID" value="HMPREF0994_03275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3579"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="302" mass="33586" checksum="CD0053C6796CB69B" modified="2011-09-21" version="1">MKFIRFEMAGKAEIGILNKEETGILPLSRIYPGFGVTIMQQVIEGAGENESSQLWEAYNGETDCPQVPLEEVKVLAPIERPVHDILCVGVNYRDHREEAAGALADFKAAPEAVYFAKRAIRILGSGEAIEARLDLDDQLDYEVELAVIIGKEGKDIPREKAEEYIFGYSIFNDISSRKLQNRHGQWFRGKSLDTYTAMGPVILHKSALPFPVEVDVRSYVNGEKRQDSNTRLFLADIPKIIEDLSKGMTLEPGDIIATGTPAGVGMGSNPPRFMKQGDEVICEIPPIGRLVNRVEMYFPGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBS4</accession>
    <name>F7KBS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253220.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03319"/>
    <dbReference type="EnsemblBacteria" id="EGN40149">
        <property type="protein sequence ID" value="EGN40149"/>
        <property type="gene ID" value="HMPREF0994_03319"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3630"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="449" mass="48939" checksum="03E50D171D40A190" modified="2011-09-21" version="1">MNKTSKTTLMTEGSIWKKIIAFAIPLFLGNLFQQLYNTADSLIVGNFLGSEALAAVSSSGSLIFLLVGFFNGIAIGAGVVIGRFYGARQIEKVQKAIHTTIAFGLAAGAALTVIGVLLTPQLLLWMGTPDDVLPNSIIYFRIYFCGSLAFVLYNIFVGILQSVGDSRHPLIYLIISSVVNILLDLLFVGVFRFGVGSAALATIISQFASAILCLILLTKSPEDYRVHFRKIRFDFFFLKQIIQNGLPSGFQNSIISIANVVVQANINSFGKMAMAGCGAYSKIEGFGFLPITCFAMSMTTFISQNLGAGKYDRAKKGARFGILCSVITAELVGLLIYGLAPVLIAAFNNDPQVVAFGTTQARTVTLFYFLLAFSHCVAGILRGAGKAIVPMLVMMCCWCIIRITYISIAVKIIPVINVIFWAYPLTWTLSSIVFLIYFLKADWIHGFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBW8</accession>
    <name>F7KBW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sporulation integral membrane protein YtvI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253266.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40195">
        <property type="protein sequence ID" value="EGN40195"/>
        <property type="gene ID" value="HMPREF0994_03365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3678"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014227">
        <property type="entry name" value="YtvI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02872">
        <property type="entry name" value="spore_ytvI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="355" mass="39112" checksum="178A9220F6568C0B" modified="2011-09-21" version="1">MEKKKAFIINFLYFAFLLCAVFLLLKYGLPMLSPFVIAFVIAYLLKRPVIFLSRKLHLPRKPAAVLLVLVFYSTIGLLISLLGIRAFSTTRDLVMNLPQIYAAHVEPVLTDIFRNVEQGLKKMDPSLVSTLEDLFNQFIQSIGQMVSSLSMSAMGTISGVASSLPGLFIKLLLMIISTFFIAADYELLTGFFLKQLDGKSKQIFLQVKKYVVGTLFVCIRSYALIMTITFIELSIGLSIIGVKNSILIAFLISVFDVLPVLGTGGIMIPWTVIAALTGDYSLSIGLLIVYLIITVIRNIIEPKIVGSQIGLHPVVTLASMFVGVQLLGVVGLFGFPISLSLLRHLNDNGTIHLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCS3</accession>
    <name>F7KCS3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03652"/>
    <dbReference type="EnsemblBacteria" id="EGN39024">
        <property type="protein sequence ID" value="EGN39024"/>
        <property type="gene ID" value="HMPREF0994_03652"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3984"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="319"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="609" mass="69449" checksum="BF6CC6CD1304AFC7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCS8</accession>
    <name>F7KCS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39029.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03657"/>
    <dbReference type="EnsemblBacteria" id="EGN39029">
        <property type="protein sequence ID" value="EGN39029"/>
        <property type="gene ID" value="HMPREF0994_03657"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39029.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="33782" checksum="EBB484CB513CC5C3" modified="2013-09-18" version="2">MKTKKESGQKGVVYNSSVSGKIFTVLNTLFMIAFVVITLYPVLNTLAISLNDGTDSLRGGIYLLPRKWTLQNYKTVIHKNNLINGAVVSVARTIIGTLTALASNALLAFIVSRKRFLFKSQLSLFWVVTMYVNGGLIPVFLLYKGLGLTNSFWVYIVPGMLSAFNMLVIRTYMTGIPDSLEESAQLDGAGYMTIFLKIVSPLCKPVYATVALFVAVGQWNSWFDAMLYNRMSDQYTTLQYELMKLLSSVTNQGASAESMKNATAASAVTPTSVRAAATILTMLPIVCLYPFLQRYFITGLTIGGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCV3</accession>
    <name>F7KCV3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253583.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03682"/>
    <dbReference type="EnsemblBacteria" id="EGN38963">
        <property type="protein sequence ID" value="EGN38963"/>
        <property type="gene ID" value="HMPREF0994_03682"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4019"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036605_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="291"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="393" mass="45086" checksum="D09AABC925131171" modified="2011-09-21" version="1">MEKYIIERIINIIHCEIRLADDTGHLLDRFGNLPENEDPFCTDPSFLRACLDREALSLPDIFCENTYIYYARLSLPDRTSLLAGPVRIIRESHDMASQMAAAHGIQVSPLKLPFCEENTFLNGILLLYHSVTGREISMTELCSYHGFPADELDLARKELNSLVFSTRESEIPHNPYSHEARKLKSIEDGSPEQLKKCQEEVWVGRLGKVADTPLRQEKNIAIIVIVLASRAAIRGGLLPELAFSMADSFIIRAERMNDILQIRSAARRFEEEFAVSVRALQKSNSKNKYVDLAKEYVYRHLHSSIGIEEISRYVGLHKDYLSQLFSRCEGITLQHYIRREKVRQAEYMLKYSDAKMDEIANQLAFCSQSHFSHCFKEEIGQTPSQYRNQFSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD38</accession>
    <name>F7KD38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253668.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03767"/>
    <dbReference type="EnsemblBacteria" id="EGN38832">
        <property type="protein sequence ID" value="EGN38832"/>
        <property type="gene ID" value="HMPREF0994_03767"/>
    </dbReference>
    <dbReference type="GeneID" id="29729548"/>
    <dbReference type="eggNOG" id="ENOG5030FHN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545660_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="173" mass="20288" checksum="8F326BE7377FEAAE" modified="2011-09-21" version="1">MLAHEDSRIQDRKLILWARFHPEFSRNVLIPEIEENSMQYHVAPQLVDNFRKCRNAENCLYFLHGYAYADIPAGQEYDLMMRINKGKIEEDSIMRCKAAVLCFFSEFRPQPIAYAWHGYHADCLIQFRDGIPDMIQELYEINQKKPIEIRQEICLCSDDTLKAIINSSPTANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDG3</accession>
    <name>F7KDG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_03898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253799.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03898"/>
    <dbReference type="EnsemblBacteria" id="EGN38663">
        <property type="protein sequence ID" value="EGN38663"/>
        <property type="gene ID" value="HMPREF0994_03898"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4242"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="120"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN38663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="217" mass="24993" checksum="8924C019FCE64EB2" modified="2011-09-21" version="1">MAEILIVEDETAINELLRRNLELVGHRCRSVYDGKAAVEVLEEQAFDLMLLDIMLPGLDGFEVYREAGEIPTIFLTAKGGLTDRVKGLRMGADDYMVKPFEMLELLARVEAVLRRTHKGGKDFTFYGVRIDFESRVIEKDGQAADCTPREYELLETLVKNRNIALSRERLLELVWGYDYEGDTRTVDVHIQKLRKKLGLEECIKTVYKLGYRLEIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDK9</accession>
    <name>F7KDK9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253855.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03954"/>
    <dbReference type="EnsemblBacteria" id="EGN38719">
        <property type="protein sequence ID" value="EGN38719"/>
        <property type="gene ID" value="HMPREF0994_03954"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4305"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356540" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="385"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN38719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="512" mass="56656" checksum="B16EBD1F6D0B63A9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDP5</accession>
    <name>F7KDP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253833.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03932"/>
    <dbReference type="EnsemblBacteria" id="EGN38697">
        <property type="protein sequence ID" value="EGN38697"/>
        <property type="gene ID" value="HMPREF0994_03932"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038570_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11579">
        <property type="entry name" value="Glyco_tran_WbsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032719">
        <property type="entry name" value="WbsX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41244">
        <property type="entry name" value="PTHR41244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14307">
        <property type="entry name" value="Glyco_tran_WbsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="368" mass="42885" checksum="215BF6C42AF67E74" modified="2011-09-21" version="1">MGNYDVAAYVWPAYTGRDKRSLMFWPEGMGEWQSVKNAVAKFPGHEWPRKPLWGYVDEADPAVMEMEIEAAAEHGVNVFIYDWYWFDGMPYLENCLNDGFLKAKNRDKMKFYLMWANHDVNYTWDIRLSWEQDCLIWKGAVNREEFENACRRVITQYFGQSNYYRIDGKPVFQIYELANLMKGLGGLEKTKDALEWFREETKKAGFPDLYLLLTAYGDTDNLSGLDNGKTIKGEDAVSYLGFSGVTHYQFAHIADIDRDYDEILADVKEIWKGMEKEYGLPYYPHISVGWDNNPRFNGFRPGIVKNNPPEEVKKGFVMAREYADSHPGQAPFVTVNSWNEWTETSYLEPDDRYGYGYLEALREVFMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDZ6</accession>
    <name>F7KDZ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04075"/>
    <dbReference type="EnsemblBacteria" id="EGN37111">
        <property type="protein sequence ID" value="EGN37111"/>
        <property type="gene ID" value="HMPREF0994_04075"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZKSE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124918_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="155" mass="17265" checksum="22C763D979BC21B3" modified="2011-09-21" version="1">METGVIQNSTVFQKNPSEPAMASPVRSLEDRDNTDKPASLPSPHDEYIKSENSSDTASGLYKVVPDENGSYKILYDDPKAEASKSSEEECTVNTDKADREIEKLKEKKEQLEQQINSASGDEGKVRELEKKLAAVEKELAQKDNDAYRRQNAVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEA6</accession>
    <name>F7KEA6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC2_membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254086.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04185"/>
    <dbReference type="EnsemblBacteria" id="EGN36465">
        <property type="protein sequence ID" value="EGN36465"/>
        <property type="gene ID" value="HMPREF0994_04185"/>
    </dbReference>
    <dbReference type="GeneID" id="29729658"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4566"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097448_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="247" mass="27121" checksum="576E6A26468123B4" modified="2011-09-21" version="1">MYEFNCILKTDLKNLYTNPMWWAGTIGLPLLLALVMGFITKGTYGGVVTSFDYYAITMMIFGALNNATLAANSFMETRIVKANMRLCNAPVPDSYIYMPKIAASFLFGAVCHTIAGAMLFFIARVSFGGKTVIYLWILLLCVEFFAVCFSIMLCCILKHEETVNMILSTAVAILCLLGGSFFPLKGLGRTVSLISNLSPVTWISNAAFRAIYDGNMLTLGVTGVSLCLLGGLCIVFTARLFNREDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KED7</accession>
    <name>F7KED7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254117.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04216"/>
    <dbReference type="EnsemblBacteria" id="EGN36496">
        <property type="protein sequence ID" value="EGN36496"/>
        <property type="gene ID" value="HMPREF0994_04216"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503326E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180015_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046169">
        <property type="entry name" value="DUF6171"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19668">
        <property type="entry name" value="DUF6171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="85" mass="9826" checksum="92F7BD6733749001" modified="2011-09-21" version="1">MEAEGKKHCLKCLLREMDKDAYFQNLHDYIAGLDEDIKADGELYEDRLAVCKQCDMLQEGMCRACGCFVELRAVIRVNGCPYDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEH6</accession>
    <name>F7KEH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254162.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04261"/>
    <dbReference type="EnsemblBacteria" id="EGN36541">
        <property type="protein sequence ID" value="EGN36541"/>
        <property type="gene ID" value="HMPREF0994_04261"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4655"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="33789" checksum="AAC18FEC3355AAA4" modified="2011-09-21" version="1">MKKGISVTKRRNQVQGILFTLPAILGFLIFTLLPMAASLYLSFTDYRISNKPLLIGVDNYVRLFSGEDYFFYKALGVTAYYVALSVPTFLIVAFFIANLLNSEIKGMVIFRTIFYLPSIVPVVATSMIWAWLFNPDFGLFNSILKSLGLPQSQWIYNEKTVIPSIVLMGIWTTGSTMVIFLAGLQDVPKQLYEAAKVDGAGYWKRMRFITIPLMTPTLFFNLIMGMINGFQVFSQAYIMTDGGPNNASLFYVFYLYREAFRNSQMARACACSWVLFIIIAVLTFITFRSSDKWVYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEI2</accession>
    <name>F7KEI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254169.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04268"/>
    <dbReference type="EnsemblBacteria" id="EGN36548">
        <property type="protein sequence ID" value="EGN36548"/>
        <property type="gene ID" value="HMPREF0994_04268"/>
    </dbReference>
    <dbReference type="GeneID" id="29729073"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4662"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013148_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="626" mass="72066" checksum="A99686F97E3EDC7A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEI6</accession>
    <name>F7KEI6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254173.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04272"/>
    <dbReference type="EnsemblBacteria" id="EGN36552">
        <property type="protein sequence ID" value="EGN36552"/>
        <property type="gene ID" value="HMPREF0994_04272"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4666"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="33561" checksum="A82FE61C0C2CCAC8" modified="2011-09-21" version="1">MNKNNSKRLKSRESRGDRIFSGVNVVILLLLCVVTLYPIWYVLCASFTSNTYLISHPGMILWPHEFTLGAYKLALTHPLLISGYKNILIVLFVSLPLNILLTLFTGYFMAAKKVMFKPAIQFLILFTMFFSGGMIPSYLNIRSLGLYNSLFALILPGAVSVYNSIICKTAIEGMPDSLMESAYIDGANDLVILFRIVAPLIKPTLAVLLLYYGVGHWNSWFNASIYLQDNSKLPIQNIMRAILIANSNVLNSAAAENDQVNQFAESIKYSTIILTTVPVLCIYPFVQKYFVKGVMIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEP0</accession>
    <name>F7KEP0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-L-AF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN36022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254220.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04319"/>
    <dbReference type="EnsemblBacteria" id="EGN36022">
        <property type="protein sequence ID" value="EGN36022"/>
        <property type="gene ID" value="HMPREF0994_04319"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4716"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010060_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="8">
        <location>
            <begin position="437"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="795"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="966"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="7">
        <location>
            <position position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN36022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122985" checksum="76974FBFA9B61579" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF74</accession>
    <name>F7KF74_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IMP_cyclohyd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254422.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04521"/>
    <dbReference type="EnsemblBacteria" id="EGN35831">
        <property type="protein sequence ID" value="EGN35831"/>
        <property type="gene ID" value="HMPREF0994_04521"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4937"/>
    <dbReference type="eggNOG" id="COG3363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169474_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020600">
        <property type="entry name" value="IMP_cyclohydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036795">
        <property type="entry name" value="IMP_cyclohydrolase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07826">
        <property type="entry name" value="IMP_cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75569">
        <property type="entry name" value="SSF75569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP_cyclohyd" evidence="1">
        <location>
            <begin position="15"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="26754" checksum="6D359D745EF0307B" modified="2011-09-21" version="1">MKLLSLEEELKSNAYPGRGIVLGRTPDGKKAVAAYFIMGRSSNSRNRIFAVDGEGIRTQAFDESKLEDPSLIIYAPVRVLGNKTIVTNGDQTDTIYEGMDKQMTFEQSLRCREFEPDGPNYTPRISGIMHIENGGYNFAMSILKSDDGCPDSCNRFTYAYENPAAGKGRFIHTYMHDGNPLPSFEGEPKMVEIKGEIDEFTDMLWNSLNEENKVSLFVRYIDIEDGTFETRIVNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF85</accession>
    <name>F7KF85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35683.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359926.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04373"/>
    <dbReference type="EnsemblBacteria" id="EGN35683">
        <property type="protein sequence ID" value="EGN35683"/>
        <property type="gene ID" value="HMPREF0994_04373"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35683.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="422" mass="46117" checksum="E773E0B5C9A8F989" modified="2013-09-18" version="2">MKIKIPYGRSFLETDINDNRVAGVITSNLDHYKSGETETQIIRKAMEHPFGTSRLVDLVKGKHKIVIIASDHTRPVPSRLIIPFILNEIKEGNPNAEIIILIATGCHRETTKQELIEKFGEEILDSVQVVIHDCDDEGQVCLGELPSGGKVYINKVAAEADLLIAEGFIEPHFFAGYSGGRKSVLPGIASRKTVYANHCSEFIADSRAKYGVLKGNPIHEDMVYAARKAGLAYIVNVVINSRHRVIGAFSGDVEAAHSEGVEFLKGLCMEEKIMAPIVITSNNGYPMDQNIYQAVKGMATAESCCEENGVIIMVAECREGCGGDGFLKTFSKEKDAGKILAGILSTGRNDTEADQWQSQILARILNKYHIILVSRADPEIVKQMHLLPACDLDQALEMADSIVGGEKKVTVIPEGLTSIIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFS4</accession>
    <name>F7KFS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254604.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04703"/>
    <dbReference type="EnsemblBacteria" id="EGN34629">
        <property type="protein sequence ID" value="EGN34629"/>
        <property type="gene ID" value="HMPREF0994_04703"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5134"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="31907" checksum="52849C292DC0D146" modified="2011-09-21" version="1">MAKQAQQQNKKKLKISTVLIFLFCCIVAFTMLVPFVWMVSASFKLNSEIFSYPVKWIPEVFRTLNYEKVWQSIPFLQYFLNTLKLAVIITLLQLFTCSLAAFAFTKLQFPGRDKIFVAYLATMMVPWHAIMIPQFIVVKAFGMYNTHLSLIVLQAFSAFGVFLLRQNMLSIPNSLHEAAKIDGCSTFGIYRKIILPLSQNGLATLTVLTFNSVWNDYMGPMIYLDSDRLKTIQLGLASFQQQFSADYGAIMAGTVCSVIPIIIVYCIGQKYIVEGVAFAGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFV1</accession>
    <name>F7KFV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04730"/>
    <dbReference type="EnsemblBacteria" id="EGN34656">
        <property type="protein sequence ID" value="EGN34656"/>
        <property type="gene ID" value="HMPREF0994_04730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5162"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356609" evidence="1">
        <location>
            <begin position="25"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="548" mass="61725" checksum="C8C23A64D8F2D385" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG70</accession>
    <name>F7KG70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254754.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04853"/>
    <dbReference type="EnsemblBacteria" id="EGN34480">
        <property type="protein sequence ID" value="EGN34480"/>
        <property type="gene ID" value="HMPREF0994_04853"/>
    </dbReference>
    <dbReference type="GeneID" id="29727699"/>
    <dbReference type="eggNOG" id="ENOG5033N2V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363617_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356871" evidence="2">
        <location>
            <begin position="29"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="768" mass="81984" checksum="0ADEF8CCD1E900E6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGI8</accession>
    <name>F7KGI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254868.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04967"/>
    <dbReference type="EnsemblBacteria" id="EGN34136">
        <property type="protein sequence ID" value="EGN34136"/>
        <property type="gene ID" value="HMPREF0994_04967"/>
    </dbReference>
    <dbReference type="GeneID" id="29727622"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5424"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022707_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038054">
        <property type="entry name" value="LD_TPept-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143985">
        <property type="entry name" value="SSF143985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="5">
        <location>
            <begin position="221"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="474" mass="53470" checksum="6A32A827049AED91" modified="2011-09-21" version="1">MSKRKLKDGQEERGGTAFRRAMIAAGCIAAAAALIYLAGTFFFAGHYYWRTWIDGTDYSFRSKEQVREELLNPSVTYELQIKGREGLEDTMTPAELEMIYVFDDTLDRLNAEMTGLKWPTMLFYRNHYELPKMVTYSEKALKERLSGTVFFDKANIHAPVNAYIGAYSPDKGYEIVEEYPGTVLDFDKVKAAVAAALEDMEDTLDLTQGGFYSDAAVKADDKALNKALEKANRYVGAEVTYDWNGEKEVIDGDLISGWITIDGSQVELDEEAVRAYINGLAKKHDTYRRDRNFTTSNGDTILLKSGSYGWWTDRAGETEALLASVRNGERVEREPLYFARGYATGRPGEDIGSSYVEIDMGNQHLYLYIDGEIILESDFVSGNISRGFGTPAGVFGLTYKERNATLRGENYTTPVDYWMPFNGNIGMHDAGWRRSFGGDIYMRNGSHGCINLPKDKAEIIYGYMEHNFPIVCYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGV0</accession>
    <name>F7KGV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254980.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05079"/>
    <dbReference type="EnsemblBacteria" id="EGN33112">
        <property type="protein sequence ID" value="EGN33112"/>
        <property type="gene ID" value="HMPREF0994_05079"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5550"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="32470" checksum="4C072EE5D538DFF7" modified="2011-09-21" version="1">MRTDGNVIRNQNKRRIMIFSIFTLIFLGLLGTAYIRSREDNVLLLLMLTPGLSALAARLITKEGTKDLFLRPYFRKNGKWYLAAWILTPLFAFMGAAIYFFIFREDFRPLSSLCAREEGIKTTVDYFRYLGTMLPLAVLVNPLMGLVQCLGEEAGWRGYLLPKLLEFMKPWKAVLLTGVIWGLWHAPVIACGFNYGTAHPIAGIFAMVVFSTVLGCIQGWLFFKTGSIWSCVVFHAALNGMDLFSPSALFMGAQVNPFLGPDPTGILGGIIFAGLAAAAFSDICRKGSEQIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH01</accession>
    <name>F7KH01_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255035.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05134"/>
    <dbReference type="EnsemblBacteria" id="EGN33167">
        <property type="protein sequence ID" value="EGN33167"/>
        <property type="gene ID" value="HMPREF0994_05134"/>
    </dbReference>
    <dbReference type="GeneID" id="29726213"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5611"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010964_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="780"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="305"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN33167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="853" mass="95877" checksum="B92842D4F9E7A3C1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH92</accession>
    <name>F7KH92_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002588990.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05231"/>
    <dbReference type="EnsemblBacteria" id="EGN33264">
        <property type="protein sequence ID" value="EGN33264"/>
        <property type="gene ID" value="HMPREF0994_05231"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5712"/>
    <dbReference type="eggNOG" id="ENOG50305ER">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2246979_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="99" mass="11337" checksum="24FB7F85105D7C0B" modified="2011-09-21" version="1">MIEYIKLFWAGAPEGEPSVILYEVDTENERLALRSIDIFADGRTRNIPDLYDGVIEITPIPTVEELNAHVWGEEFHACIIEQAEFEAIWETHTYDGALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHL2</accession>
    <name>F7KHL2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secA</name>
        <name evidence="20" type="ORF">HMPREF0994_05341</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255184.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05341"/>
    <dbReference type="EnsemblBacteria" id="EGN32782">
        <property type="protein sequence ID" value="EGN32782"/>
        <property type="gene ID" value="HMPREF0994_05341"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5835"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="1"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="87"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="422"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGN32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="855" mass="96837" checksum="5B099746569D8040" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHN3</accession>
    <name>F7KHN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255205.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05362"/>
    <dbReference type="EnsemblBacteria" id="EGN32803">
        <property type="protein sequence ID" value="EGN32803"/>
        <property type="gene ID" value="HMPREF0994_05362"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5859"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_73_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="358"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="401"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="679" mass="76026" checksum="F53896A2944A0402" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHQ7</accession>
    <name>F7KHQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA C-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32832.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360081.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05391"/>
    <dbReference type="EnsemblBacteria" id="EGN32832">
        <property type="protein sequence ID" value="EGN32832"/>
        <property type="gene ID" value="HMPREF0994_05391"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="271"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32832.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="393" mass="40606" checksum="1666BF5AC170ED9A" modified="2013-09-18" version="2">MAKKIVLAGACRTAIGTMGGSLSTTPAAELGAIVIKEALNRAGVAPEAVDQVYMGCVIQAGLGQNVARQASIKAGLPIEVPAVTMNVVCGSGLNCVNQAAQMILAGDADIVIAGGMENMSMAPYAIPQGRYGYRMGNATMVDTMVNDALTDAFNQYHMGITAENIAEQWGQTREQLDEFAAWSQQKAVAAQEAGKFDAEIVPVEVKKKKETIIVNKDEGPRPGTTAEGIAKLRPAFKKDGIVTAANASGINDGAAAVIVMSEEKAKELGVTPMATWVAGALAGVDPTIMGIGPVAATKKVMAKTGMNIDDFDLIEANEAFAAQSLAVGHDLGIDNDKLNVNGGAIALGHPVGASGCRILVTLLHEMVRRDAKKGLATLCIGGGMGCATIVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHR2</accession>
    <name>F7KHR2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05398"/>
    <dbReference type="EnsemblBacteria" id="EGN32839">
        <property type="protein sequence ID" value="EGN32839"/>
        <property type="gene ID" value="HMPREF0994_05398"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5901"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032306_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="434" mass="48127" checksum="FCC18B56B500EDE3" modified="2011-09-21" version="1">MKKKIQLQLFLDKSREREYIRLPFSVDADTESISIRYRYPSSFAGQDGPFVIEGEPCTIDLAVMMPDGRMAGSSGSDRSSILISPLGSSAGFQSCELPEGTWHIIAGAYHIPANGVAVEYEVEVTPKERRLFKGDTHVHTTASDGILKAEEAALLARRMGLDFLIFTDHNNSAQNDRFPFYEDITLIPGTEWTHYKGHAGFLGTEQAFSTPFFTASLEETRDLFKEAGENGAFRVINHPFCPLVPWEWDFSLPFDGLEVWNGVMSERNEKAAFWWHQQLCSGRKLPVTGGSDYHRPGLLGSLAMPCQCLYAPSRSRADLLKALRQGSGYVSYLPSGPQADFAAISPEGLPASFGDVAVRGEYTDILLTGLCQGDEIRLITDTAAESLIAPSGACELKLRRRFPDALFLRLELYRSYAPGLPPMKALLTNPVYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHY1</accession>
    <name>F7KHY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255318.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05475"/>
    <dbReference type="EnsemblBacteria" id="EGN32916">
        <property type="protein sequence ID" value="EGN32916"/>
        <property type="gene ID" value="HMPREF0994_05475"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="353"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="473" mass="54265" checksum="373D4F85CB30ADA6" modified="2011-09-21" version="1">MNILYLLTDQMRFDALSCNGAPVCRTPEIDRLAQHGTNFTSAYSVNALCTPARASIVTGLYPHMHGQLSNMGNFNGVFDRQVLRWKGYSHYLKKGGYQTGYIGKWHLPEEGNKEVWSFDAWDTDRDYDEYLKKKGIDYDMGVSEVQHLEWGEDAAFCGPSVLSAEDHHDGWVAAGACRMLEDFAGGEKPFMICAAFHGPHFPYAVPKPFCDSYRPEDVPRWENFNETFRDKPVVQQKELMRWNTAQLTWIDWQKVIAAYWGYCSYLDSLVGKIMSKLEHLGLAEDTMVVFSTDHGDMLGSHRLFNKGFNMYEEDHHIPLIISCPGKEEGITMNPFVNTVDLMPTFLDAAGCPVPEEVQGKSLMSMLEGEVPQGWRQESFSEFNGYESTLLTSRMVRTRKWKYVYNPFGQDELYDMESDPGELYNLAELQGFVHVLRRMRKKMLGCLMEYKDSIAEVTSWQSNSYSLFVSDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHZ1</accession>
    <name>F7KHZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571059.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05488"/>
    <dbReference type="EnsemblBacteria" id="EGN32929">
        <property type="protein sequence ID" value="EGN32929"/>
        <property type="gene ID" value="HMPREF0994_05488"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6001"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="232" mass="26246" checksum="E7452641338E1C3C" modified="2011-09-21" version="1">MRGEHSFAVPTKFFALLCAMLGIFLVKNILFTTVLVIFCFVYVGFQRNYRLMTSCGAFYLLLSLLLYAIRFWGYHTVIISEFLVLFFWSSMVMLMLFWDLFMTPPGELSSFLSSIHMPTGVILGLMVIFRFFPTMKAELKAVGLSMKNRGLTSVRQFAVHPLASVEYVLVPLLLRILQIADQLAVSAVARGAECPGVRKSYYETTMHMRDWCFLALWGIVTAAVLCVGGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI02</accession>
    <name>F7KI02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571043.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05504"/>
    <dbReference type="EnsemblBacteria" id="EGN32945">
        <property type="protein sequence ID" value="EGN32945"/>
        <property type="gene ID" value="HMPREF0994_05504"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6018"/>
    <dbReference type="eggNOG" id="COG4804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046640_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="176"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="346" mass="40088" checksum="7B9F66C6D9FA90FA" modified="2011-09-21" version="1">MENQLTPNNSMILEIRELLENARKNVAQQVNTQLLTTYWNIGRIIVEYEQQNQIRADYGKQTLKELSKELTREFGKGFSRSNLQNMRAFYLAYEKCQTVSGKLSWSHYCELLSITDENKRSFYEKESVNSGWSVRELKRQIDSSLYERLLLSSEDVNKEKVLSLAQKGVEISQPADIIRDPYVFEFLGVPENKPMLESDLEKALVAQIEKFLLELGRGFMFVGTQQRVTLNNTHYYVDMVFYNKILRAYVLIELKTKKLTPEAAGQLNMYLNYYAAEVNDPDDNPPIGIILCTEKDSIAAEYALGGLSNNIFASRYVLYMPDKEQLIAQVEAVLKNWHEKKDNRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI28</accession>
    <name>F7KI28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05530"/>
    <dbReference type="EnsemblBacteria" id="EGN32971">
        <property type="protein sequence ID" value="EGN32971"/>
        <property type="gene ID" value="HMPREF0994_05530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6043"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040918_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="543" mass="61691" checksum="152FC1D2E71D8C9C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIL7</accession>
    <name>F7KIL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_05696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05696"/>
    <dbReference type="EnsemblBacteria" id="EGN32185">
        <property type="protein sequence ID" value="EGN32185"/>
        <property type="gene ID" value="HMPREF0994_05696"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6227"/>
    <dbReference type="eggNOG" id="COG4124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016930_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364088" evidence="6">
        <location>
            <begin position="30"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="7">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="8">
        <location>
            <begin position="184"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN32185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="503" mass="56903" checksum="EDFBB207D2343640" modified="2011-09-21" version="1">MKKAETLGCLCAFVLCMSACTGSGGEHTADKPAGGEETPHEERYEAEDAQIRGNIVSRTDKEDFSGTSYVSGFTEGGDQIIFTVNNEKEGFYDLVFRASGIGGKKENTIYVDGKCEGILLTEESDVFLDSVLKRVYLTQGEHRITLEKDWGWLDLDCLYLKESAPMDDEVYQASGVLADKEADTCAEELMKYLCGIYGEKILSGQYSLYGPDGKEIQLINRLTGEYPAILGMDMKDYSLTAAERGAQPQVTEWAEEYWEKGGIIALSWHWLLPDRYVRGEWWQALYADETTIDLDAVLNGRDKEGCELLMKDLDRMALELQKLQKQDIPVLWRPFHEADGGWFWWSRGGPDCYKKLWRLMFDKFTREYNLHNLIWVYSGMGEEWYPGDAYVDIIGEDIYPAKSCISAQGDKFLNALDYTDTVKPVMLSESGFLPEPENAARDGIYWLGCVLWGEDYLIREPGCGGHSDHLLPGSVIKNFYNNDKVITRKELPDFKGIIALSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIM4</accession>
    <name>F7KIM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255510.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05703"/>
    <dbReference type="EnsemblBacteria" id="EGN32192">
        <property type="protein sequence ID" value="EGN32192"/>
        <property type="gene ID" value="HMPREF0994_05703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="42713" checksum="FAA3CD1EB76CB472" modified="2011-09-21" version="1">MQTIKRRIGIFMHQFDGGGAERMTVVLANALYEAGHEVTFIVRSGEGESRYLLRKEIPVIDMDIAECSKLEKNIRNIRSLTGVLKGQKYDVLFSVTAEMSQVAAIAALFCRRKIPLVEVLHNTLSMETHSFQKVREKAIPLLDRQFDRVVAVSQGVREDYLRVSNTSGQKVVTVYNPVIYPQICRMAEEDTGHPWLVKDRKWHTLVLSGRLSYQKNHMFMLRVLSQLSRDADYRLILLGIGELEEELKKACEQLGIGNAVDFYGYTKNPYSFYANADAVVLCSRYEGLPTVLIEAMACGARIVSADCRSGPDEILAHGKYGALVEPGKEELFAQAVRRSVKEMPDKDALRRRAEDFSLEKSVDGYLRIVEELVNGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIN7</accession>
    <name>F7KIN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255525.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05718"/>
    <dbReference type="EnsemblBacteria" id="EGN32207">
        <property type="protein sequence ID" value="EGN32207"/>
        <property type="gene ID" value="HMPREF0994_05718"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6252"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_16_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="312"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="559" mass="60749" checksum="776ABE1BF8A0BA8E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIP2</accession>
    <name>F7KIP2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPDK_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255534.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05727"/>
    <dbReference type="EnsemblBacteria" id="EGN32216">
        <property type="protein sequence ID" value="EGN32216"/>
        <property type="gene ID" value="HMPREF0994_05727"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6263"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015408_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="1">
        <location>
            <begin position="293"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="859" mass="98739" checksum="4BB3D32CD14156E2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIQ0</accession>
    <name>F7KIQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255544.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05737"/>
    <dbReference type="EnsemblBacteria" id="EGN32226">
        <property type="protein sequence ID" value="EGN32226"/>
        <property type="gene ID" value="HMPREF0994_05737"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="289"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="556" mass="64722" checksum="4D0F3E64C5903CAC" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIQ8</accession>
    <name>F7KIQ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MobC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002585086.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05746"/>
    <dbReference type="EnsemblBacteria" id="EGN32235">
        <property type="protein sequence ID" value="EGN32235"/>
        <property type="gene ID" value="HMPREF0994_05746"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZTUJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137404_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="1">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="109" mass="12518" checksum="C656287E69FCC5DA" modified="2011-09-21" version="1">MNGRKRTVQIKFRVTEAERDLILEKMKLVPTRNMAAYLRKIAIDGYIIQIDHADIKAMTAEIQKIGVNVNQIARRVNATGNAYQEDIEEIKGVLAEIWRLQRLSLLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIU6</accession>
    <name>F7KIU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002586628.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05775"/>
    <dbReference type="EnsemblBacteria" id="EGN31851">
        <property type="protein sequence ID" value="EGN31851"/>
        <property type="gene ID" value="HMPREF0994_05775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6316"/>
    <dbReference type="eggNOG" id="ENOG5032YRT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204509_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024272">
        <property type="entry name" value="MAFF-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12750">
        <property type="entry name" value="Maff2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="46" mass="4773" checksum="292B69966BBE6958" modified="2011-09-21" version="1">MAFFNSAVDVLQTLVVALGAGLGIWGVINLMEGYGNDNPGANAHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIY5</accession>
    <name>F7KIY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255590.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05814"/>
    <dbReference type="EnsemblBacteria" id="EGN31890">
        <property type="protein sequence ID" value="EGN31890"/>
        <property type="gene ID" value="HMPREF0994_05814"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6359"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1218081_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="209" mass="24314" checksum="B329AC43C3937E89" modified="2011-09-21" version="1">MTDKVIENNQVIIMGKIVSDFTFSHEIFGEGFYMVDVEVARLSDSYDIIPLMVSERLLDVEEDYKGAYVCVSGQFRSYNRHEERKNRLILSVFAREIEFVEELEESSKTNQIYLDGYICKEPVYRKTPLGREIADVLLAVNRPYGKSDYIPCICWGRNARFAGGFNVGERCEVWGRIQSREYMKKVGEEQLEKRIAYEVSVSKLELIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJE8</accession>
    <name>F7KJE8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255753.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05977"/>
    <dbReference type="EnsemblBacteria" id="EGN31331">
        <property type="protein sequence ID" value="EGN31331"/>
        <property type="gene ID" value="HMPREF0994_05977"/>
    </dbReference>
    <dbReference type="GeneID" id="29724445"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_623627_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357497" description="SGNH_hydro domain-containing protein" evidence="2">
        <location>
            <begin position="40"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="174"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="398" mass="43354" checksum="819B7FD0CAF20203" modified="2011-09-21" version="1">MRERICPVIILMNRNKKRYILPIVFCTAALFVFDVNADAAAGVPQADSVQSEAAGDIWQQQAELAAANAEAYRKAQEQYAAELAAYQQALLEQQAREKKEAQTQQNLAEAENVKTEEADGAASPTEAGPAVIPPAQSLQTLPQNGTIANGRLIAAGLLSAPVETPLKGKSISILGDSISTYQGYIPSGYACFYPETQNDVKDVTQTWWMQVLYNTGMRLAVNGSYSASAVCGDSQAEDSSAGCSTRRINELMGTDGTVPDVILVYMGANDFFRSMELGKFNGITGRGEKYYTNFTEGYELMIQKLLRTYPASRIYCMTLIEANSGDHPRINEKGNTIADFNQRIKEIAAAYGLPVIDVHNCGMEVYELNHYTSDGTHPNKEGAAKMANYVTAMLLQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJG0</accession>
    <name>F7KJG0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255765.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05989"/>
    <dbReference type="EnsemblBacteria" id="EGN31343">
        <property type="protein sequence ID" value="EGN31343"/>
        <property type="gene ID" value="HMPREF0994_05989"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="33834" checksum="AE62A5D9F7C56833" modified="2011-09-21" version="1">MKPVNIEIGADLQELTKHGSRAFPFQDYLDDLSLYPAGYIPWHWHREFEFTAVVSGQASFLTASDSCLLKEGDGLFINSDVLHSIVPVDCENCIMHNFVFAPELLQSSPDSLVMEKYLLPLMRNKSFSSCIFHGDISWEAECVRIMESLYEESQKKGYGFELMVQSHILSLFHTLAVHMPSAFAPMQSGGRDVELLKEMLHFIDLHYMDPITLKELASSFHISESTCSRLFRKHLSVSPITYLLTYRIEKSLPLLSDTRQTVTEIAYACGFHSASYYCKFFKQVKGISPRSFRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJI6</accession>
    <name>F7KJI6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255796.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06020"/>
    <dbReference type="EnsemblBacteria" id="EGN31374">
        <property type="protein sequence ID" value="EGN31374"/>
        <property type="gene ID" value="HMPREF0994_06020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6591"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_9_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="72" mass="8033" checksum="CA4B3754CF2BDF96" modified="2011-09-21" version="1">MKKKYNLTDLDCANCAAKMEDAIKKIDGVNDANVSFMAQKLTIDADESRFDSIMKEVAAVCRKVEPDCVIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJR5</accession>
    <name>F7KJR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255868.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06092"/>
    <dbReference type="EnsemblBacteria" id="EGN31446">
        <property type="protein sequence ID" value="EGN31446"/>
        <property type="gene ID" value="HMPREF0994_06092"/>
    </dbReference>
    <dbReference type="GeneID" id="29724158"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6671"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356689" evidence="2">
        <location>
            <begin position="21"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="572" mass="62473" checksum="4B08D27DD6E6C51F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJT1</accession>
    <name>F7KJT1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255886.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN30736">
        <property type="protein sequence ID" value="EGN30736"/>
        <property type="gene ID" value="HMPREF0994_06110"/>
    </dbReference>
    <dbReference type="GeneID" id="29725234"/>
    <dbReference type="eggNOG" id="ENOG5033A36">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128089_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="172" mass="20455" checksum="55C0A23FFC2A9BDA" modified="2011-09-21" version="1">MKVNELVQCYLETKDEQYFKELIDIFEPLILSYAHRLYYLEKDDSVQELTLALFESISTIHDTSDTAMCFSYIQSAIYHRFCKLYYKSKTAKEQIDRHVYIENMEALGQRSNDIDDCLFRLDLDKKLKKMDPKRKQIILLLIQGWSDAEIANVQGYSKQYINRIKKNLLKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJU0</accession>
    <name>F7KJU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255895.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06119"/>
    <dbReference type="EnsemblBacteria" id="EGN30745">
        <property type="protein sequence ID" value="EGN30745"/>
        <property type="gene ID" value="HMPREF0994_06119"/>
    </dbReference>
    <dbReference type="GeneID" id="29726881"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920668_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="180"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="302" mass="33383" checksum="0ABA2A1DAC63D8D8" modified="2011-09-21" version="1">MLLIQGTTGTNVKYLQYGLKIKCFNPKRTDGVFDANTTSALKRYQTFKRLTADGKADELTWATLKEDIKLIQASLQAKGYYTGNIDGIAGNKTYNSLIHFQLDNGLASDGMAGNATLGKLYDMSGTKIIPNFSSDGVLKEMVENMVCVALAEEFADRFEGLSETDRGKENYNKYLKWYPYQQGSPWCACFVSWCAYKAGILDIEGQARVVPRSVSVAAYCDYYIKNSRIGYPGKYIPKRGDVFILKKSGASHVGIVTGYDISVQKYSTIEGNTERDTVAQKLRSINSSTLYGFGINTDGGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB9</accession>
    <name>F7KKB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256068.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06298"/>
    <dbReference type="EnsemblBacteria" id="EGN30217">
        <property type="protein sequence ID" value="EGN30217"/>
        <property type="gene ID" value="HMPREF0994_06298"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6902"/>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376298_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="1"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="603"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN30217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="722" mass="82150" checksum="4FF9B7A0B3921E6F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKK7</accession>
    <name>F7KKK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256148.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06386"/>
    <dbReference type="EnsemblBacteria" id="EGN47994">
        <property type="protein sequence ID" value="EGN47994"/>
        <property type="gene ID" value="HMPREF0994_06386"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6990"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056148_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05390">
        <property type="entry name" value="HypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="222" mass="24888" checksum="BB02BE74D021A1E7" modified="2011-09-21" version="1">MKEYKILEIKKSIFEDNDREADELRRELKAQKTFLLNLMSSPGSGKTTTLKKTIALLKDEMKIGVMEADIDSDVDAAAISETGVKVIQLHTGGMCHLDAGMTKQGLEALETEGIDLAILENVGNLVCPAEFDTGSSRNAMILSVPEGDDKPLKYPLMFSVSDVLLINKTDVLPYFEFDMEACMERARKINPDIKIIPVCARTGEGMEEWADWLRQQVREWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKU2</accession>
    <name>F7KKU2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RelA_SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256233.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06471"/>
    <dbReference type="EnsemblBacteria" id="EGN47606">
        <property type="protein sequence ID" value="EGN47606"/>
        <property type="gene ID" value="HMPREF0994_06471"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7085"/>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077095_1_1_9"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="53"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="214" mass="24956" checksum="92DA0897A245F23B" modified="2011-09-21" version="1">MEYVVDNDNQVDSWQEVTLVYNAALKQINTKLEILNDEFQHVHRYNPIEHIKSRMKTSESIVKKLKRYGYESTIENMVKYINDIAGIRVICSFTSDIYRIADMIRNQNDIKVISVKDYMKHPKASGYKSYHMLVTVPVFLSDRIVEVKVEIQIRTVAMDFWASLEHKINYKFEGNAPQHIKTELVECARMVSDLDARMLSLNEEILSLSGETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL11</accession>
    <name>F7KL11_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6259 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256302.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06540"/>
    <dbReference type="EnsemblBacteria" id="EGN47259">
        <property type="protein sequence ID" value="EGN47259"/>
        <property type="gene ID" value="HMPREF0994_06540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7162"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497677_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046226">
        <property type="entry name" value="DUF6259"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19773">
        <property type="entry name" value="DUF6259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6259" evidence="1">
        <location>
            <begin position="224"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="552" mass="62829" checksum="FFA392ADF2160362" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL48</accession>
    <name>F7KL48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256343.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06581"/>
    <dbReference type="EnsemblBacteria" id="EGN47300">
        <property type="protein sequence ID" value="EGN47300"/>
        <property type="gene ID" value="HMPREF0994_06581"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7205"/>
    <dbReference type="eggNOG" id="COG5018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037266_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="37914" checksum="1EC66E84E7CD4DC1" modified="2011-09-21" version="1">MNYIILDLEWNQGNEQKEKQLKELPFEIIEIGAVKLNSRMEICDSFHELIRPQVYKEMHYMTKKLLHLDMEELQSGRSFLQVIKSFLAWCGEDYMFGTWGPQDLTELQRNMKFYGMEPLDKKPMKFYDVQKLFSIAFEDKKSRRNLEYAVDFLAISKDIPFHRALSDAYYTGRVLAKIKDPQVLQMISFDGFIVPHNKKEEVHIVFDDYAKYISRDFADKQELLADKEVSSTKCYLCHRNLKKKIRWFTPNGKHYYSVSYCEKHGFMKGKIRVRKTEDDRVYAVKTMKFITEEDAADIFKKKERARELRRLRKHKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL58</accession>
    <name>F7KL58_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256353.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06591"/>
    <dbReference type="EnsemblBacteria" id="EGN47310">
        <property type="protein sequence ID" value="EGN47310"/>
        <property type="gene ID" value="HMPREF0994_06591"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088525_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="156"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="255" mass="29892" checksum="45FF2833ACB255BE" modified="2011-09-21" version="1">MRYSNYTKQEILEKTREAIHMFIRKQVRPFAELLDDNFVWIGDFEPLYMKGIPAFLESVKEEIQEQPVDITEEEYALLSHESHIWITYGRFTATALGLSSRIHFTFVWRQNGNALRLLHANANHAKKMPYENAQSKIFENCNQTDHMLYPADSSKLTIRNLSGSIHYLLTDEILFMKANNKICEIVTQNGIVSCRMTLTELENFPFIRIHKSYLVNKAYIREICRYTAVLSNGIQLPIGKKWYMDLKKCLKERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRW8</accession>
    <name>S2KRW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360098.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07180"/>
    <dbReference type="EnsemblBacteria" id="EPC05184">
        <property type="protein sequence ID" value="EPC05184"/>
        <property type="gene ID" value="HMPREF0994_07180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="33385" checksum="3F05294430D5B8FA" modified="2013-09-18" version="1">MNKMGSFKTAGTKDKIFIICDYALLIFVCLIVIFPLMYVVSASFSDPSAVVNGKVWIWPVNPTLKGYQAVFKNPKIWTGFLNSFFYVIVGTTINIVVTVACAYPLSRKEFTARNVISALVVFTMYFSGGLIPTYLLVKNLGILNTRWALLLPVALSPWNMILCRTYMVNSIPDELYEAASLDGCSPFGYLVKVVVQLSKPILAVLVLYYGVGHWNAYFNAMVYLKDQNLWPLTLFLREILINSVVDPTMLSDVSAAEAARGLTDLLKYSVIVVASVPMLLIYPFVQKYFVQGVMIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSH9</accession>
    <name>S2KSH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359925.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07086"/>
    <dbReference type="EnsemblBacteria" id="EPC05237">
        <property type="protein sequence ID" value="EPC05237"/>
        <property type="gene ID" value="HMPREF0994_07086"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="278" mass="31345" checksum="A80B9CE164B19C50" modified="2013-09-18" version="1">MGYSKKRLIVKIIFTVIMGVISIAMLLPFAWMLSASFKPDNTIFAFPIDWIPDNFTWSNYNRVWNSDVPFSTFFGNSLKVTLLSVTGEVFTSSLAAYAFAKIKFKGRDVIFLIYLSTLAFPAQMMLIPRFTMFRTIGLYNTHWALILPGMFTAFGTFMLRQFFMSIPDELSESAKIDGASHFTIFSRIIMPLAVPAFSALIIFQFVSSWNEYESALVYIRSKELATIPLGLNFFKDENASSYGAIMAASVCSLIPIFIVFLIFQKQFVAGIATSGMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSY5</accession>
    <name>S2KSY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359822.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07025"/>
    <dbReference type="EnsemblBacteria" id="EPC05357">
        <property type="protein sequence ID" value="EPC05357"/>
        <property type="gene ID" value="HMPREF0994_07025"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032UKX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152427_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024997">
        <property type="entry name" value="DUF3892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13031">
        <property type="entry name" value="DUF3892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="99" mass="10453" checksum="774BAD05B4D9D810" modified="2013-09-18" version="1">MDRNDIPDSALARIALDSIPTPKDDAKDIVGLVKSSGRITGYQLSDGSTVSKEDGVALAKDGEIKGVGIAHRKDTEYLKSLPDDTESNNLGTLPSVTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAX3</accession>
    <name>S2LAX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_07019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359814.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07019"/>
    <dbReference type="EnsemblBacteria" id="EPC05351">
        <property type="protein sequence ID" value="EPC05351"/>
        <property type="gene ID" value="HMPREF0994_07019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EPC05351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="274" mass="28929" checksum="774ECA9AD08BC0D7" modified="2013-09-18" version="1">MLEYIGRMFSYPFMQRAFLVGILVSLCASLLGVSLVLKRYSMIGDGLSHVGFGALAVASALHMAPLAVAVPVVVLAAFILLRLSDSGKLKGDAAIAMISTGALAVGVMVVSVTTGMNSDLNSYMFGSILAMSKSDVVLSAVLSVIVLVLYLFFYDKIFAVTFDTVFARATGIRTGLYNMLLAVLTAVTVVLGMRMMGALLISSLIIFPALTAMRVCKHYRSVILCAVAVSVISFVLGMTVSFLLATPAGASIVIVDIAMYLIFWAAGAIRGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2R4</accession>
    <name>F7K2R4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250092.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00143"/>
    <dbReference type="EnsemblBacteria" id="EGN42760">
        <property type="protein sequence ID" value="EGN42760"/>
        <property type="gene ID" value="HMPREF0994_00143"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.152"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049285_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="28"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="35133" checksum="949D4561607542C2" modified="2011-09-21" version="1">MYINEQGAIPINGALQYVSIRSEKENAPLLLYLHGGPGDAALPLVLKYNRDLEKHYTVVVWEQRGAGKSYYKFGPEGITIAHFLEDLHTLTELLLKRFGQEKLYLVGHSWGSVLGLTYIRQHPDKIHTYIGCGQVIHMKKACREAYDFALSHAVGKELERLKRTDCSYTGEDWLHDLLFVTGLVVKYKGSLYGKSNYNMLIKPFLFSRCYTPVDLYRRQKGSLQAIRCLWQELMQTDFENCRKYDVPVIFIEGRYDSHVSSALVKKYCDTLESDKQFFLFEKSCHFPQWSENEKFNSILASLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K329</accession>
    <name>F7K329_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250207.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00258"/>
    <dbReference type="EnsemblBacteria" id="EGN37897">
        <property type="protein sequence ID" value="EGN37897"/>
        <property type="gene ID" value="HMPREF0994_00258"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.279"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="5">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN37897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="194" mass="21498" checksum="B0FF5C7F28499487" modified="2011-09-21" version="1">MTEREKMLAGLLYDCGDDELLARWHKAKNLMRDYNLTDSEDMERKNRILEELLGGRVKNLWITAPFYVDYGHHIFFGNNCEVNMNCTFLDDNIIRIGDNALIAPNVQIYTAFHPANAEDRFGNPGKDGSFAFCRTQTAPVTIGDNVWIGGGAILMPGITIGDNVVIGAGSVVTRDIPSDSVACGTPCRVIRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3C9</accession>
    <name>F7K3C9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250311.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00362"/>
    <dbReference type="EnsemblBacteria" id="EGN33503">
        <property type="protein sequence ID" value="EGN33503"/>
        <property type="gene ID" value="HMPREF0994_00362"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.392"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="72"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="28829" checksum="BB5D52284F8BCAB2" modified="2011-09-21" version="1">MNQTEKRCWLIKELQSDMPEYGALTIPETPEEQKKLLRSLMNVRPAKPVSEAFLQIQDEYLREESRLRGICDGMTLPGVKADGRISLWKGDITALKVGAIVNAANSALIGCFIPCHACIDNAIHSFAGIQLRLECDALMNRQGHEEPVGHAKLTRAYNLPCSYVLHTVGPVIQGRVSEEDRSLLASCYRSCLETAAANGITSVAFCCISTGVFHFPNRPAAEIAVKTVREFLEKDIRMTKIVFNVFKDSDLEIYQDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3F7</accession>
    <name>F7K3F7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250339.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00390"/>
    <dbReference type="EnsemblBacteria" id="EGN33531">
        <property type="protein sequence ID" value="EGN33531"/>
        <property type="gene ID" value="HMPREF0994_00390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.424"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="457" mass="49070" checksum="68EA7D656DF841C5" modified="2011-09-21" version="1">MKSSKKIDMTQGSIMRQVLIFALPICAGNVLQQLYGTVDTLVIGNFCGSVSLAAVGTSSQPVEMLLCIFLGLGTGVSILVSQFSGSGDGKSQREIVATAISFLYICAIPLAVIGQFAGPLVLKIMQVPPDTWDLANSYIRIIFIGTLGNMGYNMNAGILRGVGDSRASLLFLLVSCVVNIALDLLFVAGLGMDVAGAALATMLAMYCSWLFSVAYIRRQYPELGFTLLPKRLNKAMLAAIVKIGLPLGLNGSIYSVGHILMQSLINMQGSVFIAACAVSGKVTGIANVAINSLSSAATTFSGQNLGAKNYVYLKKGGLQIPLFSGLITCMAGLLVTFFSRPLLSLFTKDPAVLDFAVRYIRIVLPFTWTFAVFNGIISFVNGMGEVRFPTIVNLLMLWAVRIPVGYLITYFIDGGYVMACLPISFAFGMLCMLSYFFSGQWKKIKEQAACQQEETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3H9</accession>
    <name>F7K3H9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250357.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00408"/>
    <dbReference type="EnsemblBacteria" id="EGN31923">
        <property type="protein sequence ID" value="EGN31923"/>
        <property type="gene ID" value="HMPREF0994_00408"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.448"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="29968" checksum="673216F3AE8C3725" modified="2011-09-21" version="1">MRRILLVEDEKMIRYGIYVMIENSGVPYNEITECRNGKDAVEYLKNTRYDLVLTDIKMPIMGGLELSRWICDNLDEEERPLIVAISGYAEFEYVKGMMKFQSMDYLLKPVDREELGKILWNAEEILRKRSVESPDMGNPGDTEVTGVSRYKMQRAIDYIRQNYGKPIDMAEVSNYVSMNYSMFSTTFKEFTGENFSSYLRKLRIEKSKKLLLNTDMSILEISQKVGFEDARRFAKVFKEETGLTPTASRDKMMAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3M0</accession>
    <name>F7K3M0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250398.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00449"/>
    <dbReference type="EnsemblBacteria" id="EGN31964">
        <property type="protein sequence ID" value="EGN31964"/>
        <property type="gene ID" value="HMPREF0994_00449"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.493"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="344" mass="37473" checksum="8D0F2C5D07D0C9D4" modified="2011-09-21" version="1">MTEKKVPFIEVKNLVVHYTSEGREIHAVNDVSFSLEKGRTLGLVGETGAGKTTIAKSILRILPEPPAHVDGGEICLEGKNLLELHNDEMRKIRGKRISMIFQDPMTALNPVMRIGNQIAEGIELHEKCSRKEAEAKAAAMLEMVGIPGTRFRDYPHQFSGGMKQRVIIAMALACSPDLLLADEPTTALDVTIQAQVLDIIKTLQQRLQTAMIMITHDLGIVAEVCDEVAVIYAGEIVEYGSKEEIFDHPSHPYTIGLFGSLPDINSDVERLSPIAGMPPDPGNLPEGCSFSPRCPYASDKCRKGDVKLINIGGTHTCRCIRAAAAEDKTAFSDGGQKKTAEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3N4</accession>
    <name>F7K3N4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250412.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00463"/>
    <dbReference type="EnsemblBacteria" id="EGN48181">
        <property type="protein sequence ID" value="EGN48181"/>
        <property type="gene ID" value="HMPREF0994_00463"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.510"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="119"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN48181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="329" mass="36923" checksum="43361D3B34DF47BF" modified="2011-09-21" version="1">MLRNREFRQFAVIFFLIAAASVTLGFANNIAAGILALFSSFAFGTAFFVLTKARYKSLMQISEQIDLVLHNADHLFITESEEGELSILQSEITKMMLRIREQNDALKKEKEHLADSLADVAHQLRTPLTSITLVLSLIENTSDEKERKNLIRETEELLVRMDWLLTSLLKLSRLDAGIVVFQKEQVNINSLITAALRPLLIPMELHNISLQADVPPGITIEGDFNWLSEALQNIFKNCMESAGDNGKIDIHCEDNPIFTEITIHDSGEGFKKEDLPNLFNRFYRGQNSSTAGYGIGLALCRTIITRQGGSITARNHPRGGAMFVIRFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3W8</accession>
    <name>F7K3W8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FlhB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00547"/>
    <dbReference type="EnsemblBacteria" id="EGN44735">
        <property type="protein sequence ID" value="EGN44735"/>
        <property type="gene ID" value="HMPREF0994_00547"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="160" mass="16781" checksum="147DFAB7E34FA432" modified="2011-09-21" version="1">MSKYKKNKAAALKYNMEEDTAPVVIASGYGPMAEKIIDIAEQKGIPVFKDDSAASLLCMLDVGTNIPVELYEVIAAIYGKLMEASAKTHGNSPAVGKTPAAGKSPTAGKSPTAGKTSASAEYKTQNAEAGPEKRTTRPSLRDGLVSAGKKETEKDSTETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4J4</accession>
    <name>F7K4J4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250722.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00773"/>
    <dbReference type="EnsemblBacteria" id="EGN43482">
        <property type="protein sequence ID" value="EGN43482"/>
        <property type="gene ID" value="HMPREF0994_00773"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.838"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356632" evidence="2">
        <location>
            <begin position="26"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="463" mass="49838" checksum="E4F946F67A9EB621" modified="2011-09-21" version="1">MKRKLLACVLACTMAASLAGCGSSASQTANDSKPAESVAAEQSQASEESTPAEESAAETGELDVKSGTTLNVTTTFAGEESNVQNYQDSVKRWEEKYGCTVADSSGTADETFKSRVISDFEAGAEPDVLFYFNGNDSNPFVEAGKVVTIDEIRSVYPDYASNMKDEMIPACPADGKQYAVPFYGYWEGMYVNKSVCEQAGVEVPGANTTWDEFLEICQTIKDAGFTPIAASLAKEPHYWFEFSIYNHDTPATHASVPASLDDAAGKAWAAGLGDIKDLFEKGYFSENTNTAEASEVFQSFIDGKAAFYVDGSWKMGGIAESTDDIDNFTVTFVPGANDRKASDIISGLSSGWYITKKAWDDPEKRAAAVSFITDMITDENVSLFAQTAATALKNGVQLDEASLNSLQKDSLVMIKTATGVTDAAQDLCTQEQRAPIFDHMPEIVTGSVSIEDAISQVLENMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K540</accession>
    <name>F7K540_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250927.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00978"/>
    <dbReference type="EnsemblBacteria" id="EGN43287">
        <property type="protein sequence ID" value="EGN43287"/>
        <property type="gene ID" value="HMPREF0994_00978"/>
    </dbReference>
    <dbReference type="GeneID" id="29724406"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1069"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010993_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1035" mass="119525" checksum="B7DC6E832223F085" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K559</accession>
    <name>F7K559_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250946.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00997"/>
    <dbReference type="EnsemblBacteria" id="EGN43306">
        <property type="protein sequence ID" value="EGN43306"/>
        <property type="gene ID" value="HMPREF0994_00997"/>
    </dbReference>
    <dbReference type="GeneID" id="29725158"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1088"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006968_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1169" mass="129894" checksum="4B87FA752DAA8315" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K566</accession>
    <name>F7K566_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antibiotic transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250953.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01004"/>
    <dbReference type="EnsemblBacteria" id="EGN43313">
        <property type="protein sequence ID" value="EGN43313"/>
        <property type="gene ID" value="HMPREF0994_01004"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1095"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="239" mass="26793" checksum="EF0576FA75625AEA" modified="2011-09-21" version="1">MEAPISVKGLRKAYQGVPAVRDISFSVNPGEIFGLLGENGAGKSTTIECLLGTRRPDSGSTSILGMDPVKDRKRLFQKVGVQFQEPYYPDRIRVSELCEETASLYRSSQNYEKLLEQFGLAEKKELMVSKLSGGQKQRLFIVLALIPGPEVVFLDELTTGLDTKARREVWNHLLSLRQKGLTILLTSHFMDEVAILCDRIAILKKGQIIFEGTVDDAVARSPHDNLEDAYLWFMESEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5C1</accession>
    <name>F7K5C1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250999.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01050"/>
    <dbReference type="EnsemblBacteria" id="EGN43023">
        <property type="protein sequence ID" value="EGN43023"/>
        <property type="gene ID" value="HMPREF0994_01050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138400_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="122" mass="13545" checksum="F712551C896A05DC" modified="2011-09-21" version="1">MATGIICIIILMACVFGIKSYAKRLSHGCCGGGGETIKKIRPADKQKSHYLHTYKLEIEGMTCSNCSTRIENAFNTREGCYARADSGKRTATLHSKHPLTESEAREIIRKAGYRLKSFQTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5G9</accession>
    <name>F7K5G9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01098"/>
    <dbReference type="EnsemblBacteria" id="EGN42860">
        <property type="protein sequence ID" value="EGN42860"/>
        <property type="gene ID" value="HMPREF0994_01098"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1204"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="500"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="613" mass="69826" checksum="70B29B95B513574E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5L6</accession>
    <name>F7K5L6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chlorophyll synthesis pathway protein BchC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251098.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01149"/>
    <dbReference type="EnsemblBacteria" id="EGN42911">
        <property type="protein sequence ID" value="EGN42911"/>
        <property type="gene ID" value="HMPREF0994_01149"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1260"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="8">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="7">
        <location>
            <begin position="180"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="348" mass="37216" checksum="7F6155D98E1D10B5" modified="2011-09-21" version="1">MNGTMKTAVMTGISQVEIQQRPIPVPADDEVLVKVEYVGICGSDLHYYESGRIGNFIVEPPFVLGHEAGGTVVEVGAGVKDLKVGDRVALEPGKTCGHCEHCKEGKYNLCEDVIFFATPPVDGVFQEYVAHEAGLCFRLPDNMSTMEGALIEPLAVGMHAANQGGAHLGQTAVVTGAGCIGLCTLLSLRAMGVSKIIVVDIMQKRLDKALELGADYVINGKEEDTVARIRELTGDKGADLGIETAGSQITASQLIQAAKKGSTIVFVGYSASGEMTLPIGMALDKELNFKTVFRYRNIYPMAIEAVSSGRINIKNIVTDYFELDDIKNALDSCVNNKAEIVKGVIKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5U6</accession>
    <name>F7K5U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system, response regulator, stage 0 sporulation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251174.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01225"/>
    <dbReference type="EnsemblBacteria" id="EGN42551">
        <property type="protein sequence ID" value="EGN42551"/>
        <property type="gene ID" value="HMPREF0994_01225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072509_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="163" mass="18590" checksum="8385395F54AE12E0" modified="2011-09-21" version="1">MSCMWVSVADCNQSHIFQLTQLLRQDKELQIILSYGAPYADNRGNCSSQSRIERLLSRIGMPSHLKGYQYLKTALAICLEDMEELDGITKKLYPAVARKHKTTAEKVEHAIRHAIESAWKRGDEKVHKSLFGYCQTEGKRPTNSEFIARMADYLLHDTTSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K634</accession>
    <name>F7K634_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FkbH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251262.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01313"/>
    <dbReference type="EnsemblBacteria" id="EGN42175">
        <property type="protein sequence ID" value="EGN42175"/>
        <property type="gene ID" value="HMPREF0994_01313"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1435"/>
    <dbReference type="eggNOG" id="COG3882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018095_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010037">
        <property type="entry name" value="FkbH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01686">
        <property type="entry name" value="FkbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="596" mass="69371" checksum="4146F96E54E21BDC" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6G5</accession>
    <name>F7K6G5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251422.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01473"/>
    <dbReference type="EnsemblBacteria" id="EGN41947">
        <property type="protein sequence ID" value="EGN41947"/>
        <property type="gene ID" value="HMPREF0994_01473"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1606"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="35450" checksum="5918883036B4DB5B" modified="2011-09-21" version="1">MSLLSVIVPCYNEEENVDCFYEELMKNTPFFEKEGLDVEILYVDDGSKDRTVEEVKDLKTRDDRVRLVSFSRNFGKESAIFAGLQKAKGDYVVMMDADLQDPPALLPEMFSYIKEGYDSVATRRVTRKGEPPIRSFFARMFYKLVNRISKTEIVDGARDYRLMTRQVVDAILQMTEYNRFTKGIFGWVGYSTKWLEFENVERAHGETKWSFWKLFIYALDGIIAFSTVPLALASILGVIFCFIAFLLIIIIVIKTLAVGDPVGGWPSMVCIICMVSGVQLFCLGIVGQYMSKTYMEVKKRPIYLVKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6S0</accession>
    <name>F7K6S0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Excisionase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002566648.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01587"/>
    <dbReference type="EnsemblBacteria" id="EGN42061">
        <property type="protein sequence ID" value="EGN42061"/>
        <property type="gene ID" value="HMPREF0994_01587"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1736"/>
    <dbReference type="eggNOG" id="ENOG5032S7G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170320_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015122">
        <property type="entry name" value="Tn916-Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09035">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004323">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="67" mass="7895" checksum="C6824285ACD18202" modified="2011-09-21" version="1">MSNNDVPIWEKYTLTIEEASKYFRIGENKLRRLAEENPSAGWVILNGNRIQIKRQKFEKIIDSLDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K721</accession>
    <name>F7K721_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN41902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251377.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01428"/>
    <dbReference type="EnsemblBacteria" id="EGN41902">
        <property type="protein sequence ID" value="EGN41902"/>
        <property type="gene ID" value="HMPREF0994_01428"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1556"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="325" mass="36357" checksum="E36A61F9BA803111" modified="2011-09-21" version="1">MGYKNLQFDKDSVFLVTGGAGFIGSNLCEAILDMGYQVRCLDDLSTGKQENVEMFLDRPGYTFIKGDIKDLETCRRACDGVDYVLNQAAWGSVPRSIEMPIFYEQNNIGGTLNMMEAARESGVKKFVYASSSSVYGDHPALPKKEGIEGEVLSPYALTKRTNEEYGKLYKKLYDLDTYGLRYFNVFGRRQNPDGMYAAVIPKFLKQLLHDEVPTINGDGKQSRDFTYIDNVIEANLKACLASGDAAGEAYNIGSGGREFLIDIYYDLCKALGKEMEPNFGPPRRGDVRDSNADITKARENLGYDPDYDFASGIKLAIDWYKENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7D1</accession>
    <name>F7K7D1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated endoribonuclease cas6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01760"/>
    <dbReference type="EnsemblBacteria" id="EGN41573">
        <property type="protein sequence ID" value="EGN41573"/>
        <property type="gene ID" value="HMPREF0994_01760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1921"/>
    <dbReference type="eggNOG" id="COG1583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101010_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="230" mass="27281" checksum="15B346E00ECC6855" modified="2011-09-21" version="1">MLVFEYKLRVRLLKSFEYVKASEAVSYFLDSALGKEEDFLKLHERREYKYYTMDSFYPCEKDGIYKQGKIYAIRIRTVKQELAEYFSRMLIHHTSGEMEGLTGELRIIPKKQLERVYSLTPVIIKTEKGYWREHMSVPEFEDRIKINLIKKYNQFNHTKIEENFQLYNLIEFKNKVPVKVPYKNITLLGDKINLIASNDPMAQELLYFSLGTGLGENNARASGFMNYQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7H5</accession>
    <name>F7K7H5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251717.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01804"/>
    <dbReference type="EnsemblBacteria" id="EGN41617">
        <property type="protein sequence ID" value="EGN41617"/>
        <property type="gene ID" value="HMPREF0994_01804"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1969"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="181"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="383" mass="42598" checksum="6C27DEF3ED8515EB" modified="2011-09-21" version="1">MDNKWDMLESSNEDREKIWTKNRTFAGDVWFRFRHKPTSIAGFVIILLLILFAAFGPLFTKYSYSVQDLEVVNIPPRMKVYETPDNTGYLYITQAMKVLQVNSDGTLGIQLKKVREESERMMTIFDCNGTEVALYYGQKPYVIANPENNTIYRSKNIWNKSYLLGTDNLGRDILTRLMYGTRVSLMVAFVAVAVNLVIGVLYGGISGYLGGNVDAVMMRIVDIISTIPLTLYVILIMVILGSGLQSIVIALGTVYWVDMARVVRGQVLGLKEQEFVQAAKTIGSSTKTILLSHLIPNAMGSILVTVTMLIPSAIFMEAFLGYLGIGLQPPLASLGTMCNDATENLRSCPHQLFIPALVICLIMFAFNFVGDGLRDALDPKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7S7</accession>
    <name>F7K7S7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">HMPREF0994_01972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251885.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01972"/>
    <dbReference type="EnsemblBacteria" id="EGN41377">
        <property type="protein sequence ID" value="EGN41377"/>
        <property type="gene ID" value="HMPREF0994_01972"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2167"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="194" mass="21357" checksum="958374F9F8FB4D57" modified="2011-09-21" version="1">MYIIAGLGNPKREYENTRHNVGFDVIDALADKYGIRVIERKHKALVGRGYIDGMKVVLAKPQTFMNLSGESIREIIDYYKVDPQTELIVVCDDISLDLGQLRIRKKGSAGGHNGLKNIIAHLGTDGFARIKMGVGNKPEGYDLADYVLGHFTGGERKIMDECIALAVEAAVTMMEKGPDEAMNRFNGKRAGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7T0</accession>
    <name>F7K7T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251888.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01975"/>
    <dbReference type="EnsemblBacteria" id="EGN41380">
        <property type="protein sequence ID" value="EGN41380"/>
        <property type="gene ID" value="HMPREF0994_01975"/>
    </dbReference>
    <dbReference type="GeneID" id="29727034"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2170"/>
    <dbReference type="eggNOG" id="ENOG50331G5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579653_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="471" mass="52025" checksum="971E1BCC47E43EDC" modified="2011-09-21" version="1">MNKGKENYNNIPLPDGLSDAIRTGLDRGQKYTAKKWITGFGSLAAACLCLVVIMRIFPFTNGTGGDNSNIPSPANSSDTPVTPQAFSDERPVEVQEPENYRIPCKQTSETSPKMPVYHVEEKWAPHRLIFTLYDIRDFDFDAVSKPLLESSMVQDVYRSILLDDSAVSFVVELPINIEYQLSEHTGDGYVELSLRPSDTADEIREIYFLSSPEMDGGEETALFRESLPAGEYSIVKTREGKFLVVTGEFETQQEAEEMLAQLEQNGMEPGTLQVASCMSDESPAGSASQDTVTLPETTMPSSIRVYGTVTEINGSQVTISNDNQEDPYSTIILNINEDTLILTAEDCKEKTLKDLQKGDTLYAYVSPVMTRSLPPMSNAELILCQIPADMMVPTYAAITDVSSDPDGSLRIITDQELVCYINEDTIIKTLDGKKDLDSSALQSGNKILIWYQIATLSIPAQTNPDEIRVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7V6</accession>
    <name>F7K7V6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ORF">HMPREF0994_02002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251915.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02002"/>
    <dbReference type="EnsemblBacteria" id="EGN41407">
        <property type="protein sequence ID" value="EGN41407"/>
        <property type="gene ID" value="HMPREF0994_02002"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2198"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="182" mass="20711" checksum="C2CFDE0E45C77D06" modified="2011-09-21" version="1">MAKLVSETYGEALFSLGMEKEIVDSLMDEIDSLWKILKENPGFSSLMNHPDIGRDEKIEILHNVFEGKLSDTLYGFLEVLIHKGRYGAIDDIFTYYTDRYKAFHKIGVAYVTSAGALTDGQKARIEKRLIETTQYSKMELHYSLDKDLIGGLVIRIGDRVVDSSIRTKLEGLQRQLMKVQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7W0</accession>
    <name>F7K7W0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251919.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02006"/>
    <dbReference type="EnsemblBacteria" id="EGN41411">
        <property type="protein sequence ID" value="EGN41411"/>
        <property type="gene ID" value="HMPREF0994_02006"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RUQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147317_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="166" mass="18533" checksum="CEB6340C1C570183" modified="2011-09-21" version="1">MMKNLLEKVNETVLELWTGILLWGIVCQLIPVWFLKEKADYSLGLWLGILLAGASAFHMWWALDRGLSRGGAAQGYIRKTAFIRYAVIVVVFAVVMLTRAANPLAVFLGIMGLKAAAYLQPFVHRRLHPDKEGEGEAFVLQDPPEWNGHPDGTDGAENMEKKEVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Y0</accession>
    <name>F7K7Y0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251939.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02026"/>
    <dbReference type="EnsemblBacteria" id="EGN41431">
        <property type="protein sequence ID" value="EGN41431"/>
        <property type="gene ID" value="HMPREF0994_02026"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2223"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="229" mass="25828" checksum="091AC518C311145D" modified="2011-09-21" version="1">MIQIRNLKKVYNRNQKNAYTALRNVNLQISKGEMAAIIGKSGAGKSTLIHIMACMDDYDEGEYFLKKKLVKGLPERKAARIRNECIGIVMQDFALVEEFTGLENVMMPLDFSRRKIKGKEEKALEALEKVDMEEMADCPVNELSGGQKQRIAIARAIVNNPDVILADEPTGALDTENSGRILELFLELNREGKTIVIVTHDISIAKRCKRIIEIRDGEIFTPEKSFSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K874</accession>
    <name>F7K874_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252006.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02093"/>
    <dbReference type="EnsemblBacteria" id="EGN41498">
        <property type="protein sequence ID" value="EGN41498"/>
        <property type="gene ID" value="HMPREF0994_02093"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030JS2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120909_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="188" mass="21661" checksum="9C72B5FBA48741EF" modified="2011-09-21" version="1">MNMIQCTNEQIHVEDYLYLVSTVISLYITPHTDITSMKYDDLYQTGCLTLCKATASYHAEKDASFATYAAIVIRNQFYDYCRRMYYIHTRLLYLDASLSEEGKDTLLQSQRIDQTVQTSDIFPLLLEIHEEYSGITAKGVEALLLRNTGYTDKEIAKMFHVKPNHISAWISRANSRLRKDPRILAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8D3</accession>
    <name>F7K8D3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-ribose pyranase</fullName>
            <ecNumber evidence="2">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251822.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01909"/>
    <dbReference type="EnsemblBacteria" id="EGN41314">
        <property type="protein sequence ID" value="EGN41314"/>
        <property type="gene ID" value="HMPREF0994_01909"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2092"/>
    <dbReference type="eggNOG" id="COG4154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120075_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="146" mass="16040" checksum="71DE2441BC4DBF10" modified="2011-09-21" version="1">MLKGIPSILSPELLKVLCEMGHSDRIVIADGNFPVESMGKNAKVVRLDGHGVPEILDAILQVFPLDTYVEHPVNLMEVMPGDPVKTPIWDEYKDIISRHDGRGSAVVGNIERFAFYEEAKTAYAIVATGEMAVYANVMLQKGVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8D7</accession>
    <name>F7K8D7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252029.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02116"/>
    <dbReference type="EnsemblBacteria" id="EGN41023">
        <property type="protein sequence ID" value="EGN41023"/>
        <property type="gene ID" value="HMPREF0994_02116"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2318"/>
    <dbReference type="eggNOG" id="ENOG502ZANJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129326_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="156" mass="17556" checksum="7D98C014FD84B5BE" modified="2011-09-21" version="1">MQEDIEQRTMSVTVQAAKLSGRVLKAAIAAALQKMEHSRNTPKVGRNSMKRLTARDPGASTIEVTGRIRSFERIAKKHEVRYHIEKDPGTDPPKWTVYFKANQADALTAAFKEYTRKDLARSTRPSLLSQLAKFKELAQALGRDKVKNKEHGGPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8H4</accession>
    <name>F7K8H4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41062.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359796.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02155"/>
    <dbReference type="EnsemblBacteria" id="EGN41062">
        <property type="protein sequence ID" value="EGN41062"/>
        <property type="gene ID" value="HMPREF0994_02155"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_29_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41062.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="216" mass="24218" checksum="837F76AB534AC9D3" modified="2013-09-18" version="2">MAKKYNSQATIEAILSVSARLLLEKGFDKTSMKDIAETAGISKGAIYHHFQSKDEIIEAVMEKQAHTVTAAMEGWLADADSLNGREKLQFLLKKNIESQEAHCLDDILSARMKSAEFVLSYMQDCVNKDSAFISEIMKEGIADGSLSTEFPEECAEVFLLLMNVWCDPAVFSGNAGKLEQRMRFLQHMMKAVGIDILNDELMEKSLHLIQKIYAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8K1</accession>
    <name>F7K8K1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_02189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252102.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02189"/>
    <dbReference type="EnsemblBacteria" id="EGN41096">
        <property type="protein sequence ID" value="EGN41096"/>
        <property type="gene ID" value="HMPREF0994_02189"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2394"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="202"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN41096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="444" mass="48101" checksum="170473C4069C90DE" modified="2011-09-21" version="1">MSYVDEVIAQVVEKNPAQPEFHQAVKEVLESLRVVVEANEEAYRKDALLERLVNPERQIMFRVPWVDDKGQVHVNTGFRVQFNSAIGPYKGGLRLHPSVNLGIIKFLGFEQVFKNSLTGLPIGGGKGGSDFDPKGKSDREIMAFCQSFMTELYRHIGADTDVPAGDIGTGAREIGYMYGQYKRIRNVYEGVLTGKGLTYGGSLARTEATGYGLLYMTKEMLKCNGIDIAGKTIAVSGSGNVAIYAIQKAQEMGAKVVTCSDSTGWVYDPEGIDLAALKEIKEVKRGRVSDYLNYRPNAEYHSGKGVWSVKVEIALPCATQNELALSDAEGLVANGVKAVCEGANMPTTLEATEYLQKNGVLFVPGKAANAGGVATSALEMSQNSERLSWSFEEVDSKLQGIMINIFHNLDDAAKRYGMEGNYVAGANIAGFEKVATAMTAQGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Q8</accession>
    <name>F7K8Q8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase J</fullName>
            <ecNumber evidence="1">2.1.1.242</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m2G1516 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmJ</name>
        <name evidence="2" type="ORF">HMPREF0994_02254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanosine in position 1516 of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43220"/>
            <dbReference type="Rhea" id="RHEA-COMP:10412"/>
            <dbReference type="Rhea" id="RHEA-COMP:10413"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.242"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.242" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02254"/>
    <dbReference type="EnsemblBacteria" id="EGN41161">
        <property type="protein sequence ID" value="EGN41161"/>
        <property type="gene ID" value="HMPREF0994_02254"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2462"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076324_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01523">
        <property type="entry name" value="16SrRNA_methyltr_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007536">
        <property type="entry name" value="16SrRNA_methylTrfase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36112">
        <property type="entry name" value="PTHR36112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04445">
        <property type="entry name" value="SAM_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="28786" checksum="B12CC7EBAFBEFF97" modified="2011-09-21" version="1">MSDLDDKDMEIISKSDMDREVSPQLDEQLITDIIKKDAYGKNTDLTLRPDKDGLTLAGNSQSLRGDFTRMRSRINPGNLNRELLIKASKIKGKAEGLTAVDATAGLGEDAFLLAAAGFSVRLYERDPVIAALLRDALSRAAELPDLAAIVGRMEFFETDSLTALPQLGFRPDVVLLDPMFPARQKSALIKKKFQLLQQLEQPCTDEDALLHAAIASAPYKIVIKRPLKGAWLADRKPDYSLKGKTIRYDCIVLTNSGREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8W5</accession>
    <name>F7K8W5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252231.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02330"/>
    <dbReference type="EnsemblBacteria" id="EGN41237">
        <property type="protein sequence ID" value="EGN41237"/>
        <property type="gene ID" value="HMPREF0994_02330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2548"/>
    <dbReference type="eggNOG" id="ENOG5032SPU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177593_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024227">
        <property type="entry name" value="DUF3795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12675">
        <property type="entry name" value="DUF3795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="88" mass="9852" checksum="1B4B346D0889A899" modified="2011-09-21" version="1">MYESRCGVCCDSCERKEAVHCSGCLNMEKPFWGGLCGVKACCEEKKLNHCGECTEFPCEMLSLMGVDQGFDPTIKIEQCRKWAEEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K948</accession>
    <name>F7K948_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252289.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02388"/>
    <dbReference type="EnsemblBacteria" id="EGN40787">
        <property type="protein sequence ID" value="EGN40787"/>
        <property type="gene ID" value="HMPREF0994_02388"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2615"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="313"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="538"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="599" mass="67637" checksum="8CC36B2540B7A0EF" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9L0</accession>
    <name>F7K9L0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252481.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02580"/>
    <dbReference type="EnsemblBacteria" id="EGN40979">
        <property type="protein sequence ID" value="EGN40979"/>
        <property type="gene ID" value="HMPREF0994_02580"/>
    </dbReference>
    <dbReference type="GeneID" id="29724562"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2826"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="160"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="30595" checksum="6692F19485896F7E" modified="2011-09-21" version="1">MNPFYEKRSGKLQIGVSDNMNFPAHLHDDVEVLYCLEGGVQVSVMGETHLVGKGECAVIFPERVHSYRSEDNSRALLFIFSTAMSGTYGRTIQKYYPENPFLEKKDIPPDARLAFRRLCSGDVQKDDKLCIAWIQVILASLFPRFELREDERPEDMDLTYRLVRYVMEHFQEPLSLEELARNLHVNKYYLSHTFSSRLQMNFREYLNRIRLEYATQQIRSTRKPLTEIWEDAGFESQRSFNRVFHEAVGMSPKEYRGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA93</accession>
    <name>F7KA93_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate carboxyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252844.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02943"/>
    <dbReference type="EnsemblBacteria" id="EGN40552">
        <property type="protein sequence ID" value="EGN40552"/>
        <property type="gene ID" value="HMPREF0994_02943"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3211"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="481" mass="55000" checksum="FD292B6368F84C54" modified="2011-09-21" version="1">MNSNETFSNRPVSMNDKNNLLEIEEHMYILDDVEKPNVFRNMFPYSEIPKIPFNDRIVPHNMPKDIWITDTTFRDGQQSRAPYTTEQIVDIYDYMHRLGGPNGMIRACEFFLYSKKDRDAVYKCMERGYQFPEVTSWIRASKEDFKLVKEIGMKETGILVSCSDYHIFMKLKMTRRQAMEHYLSVIRECLEEGISPRCHLEDITRADIYGYVVPFCLELMKLMKEYKIPIKIRACDTMGYGVNYPGAVIPRSVPGIIYAIHTHAGVPHALIEWHGHNDFYKAVSNSTTAWLYGCSGVNASLFGIGERTGNTPLEAMVFEYAQLKGDLNGMDTTVITELAEYYEKEIGYHIPERTPFVGKNFNVTRAGIHADGLLKNEEIYNIFDTEKFLNRPVICAVSNTSGLAGIAHWINTYYRLKEEDQVSKTSELVHEVKDWVDEEYAGGRVTVLTDEELIKVIDNACEKLGISLGGSQKNAAGKLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAE4</accession>
    <name>F7KAE4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MurNAc-LAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252671.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02770"/>
    <dbReference type="EnsemblBacteria" id="EGN40379">
        <property type="protein sequence ID" value="EGN40379"/>
        <property type="gene ID" value="HMPREF0994_02770"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050365_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363843" description="MurNAc-LAA domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="94"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="347" mass="38095" checksum="475BDD9CCCC1E963" modified="2011-09-21" version="1">MKKKITIITFLLAVCALAWMPGIQAQAKEPVIVVIDPGHGGEENRGGEVLPHYVEKNLTLQVAQAMKQTLEQFEGVEVYLTRTTDQELSLEQRAQIAKAYHADFLFSLHFNMSAEHNLYGTEVWTSAFGKYYTAGQTFGRLQLAEMSQYGLYNKGVKTRLNSRGTDYYGVIRASRALDLPCVIIEHCYMDHPIDSLQANTPQKLVNFGVSDAIAVAKYFHLKSASLGLDFSNYQYSKVPAPAGGVAVPDSTPPENVNMVITNTDLNTGKVDISLSASDPQSGMLYYSYSIDGGITWSVLTPWAGGNTIQFSITVPGGSQPIIMCRAYNGYDYHTDSNFAVPGVFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAM2</accession>
    <name>F7KAM2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252749.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02848"/>
    <dbReference type="EnsemblBacteria" id="EGN40457">
        <property type="protein sequence ID" value="EGN40457"/>
        <property type="gene ID" value="HMPREF0994_02848"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3116"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="203"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="35822" checksum="5B6D48508F1A6EB5" modified="2011-09-21" version="1">MKTSKTGKTQIITNPSQKELKEHGSYPFPFLVSYESLSGYDTGSFLWHWHSEIEFTLITEGRMIYQVNDRCFLMKEGEALFGNSSTLHSGHMADETDCEYISITFAPRLLYGYEGSLIQEKYVAPVLHHRGLAAIHFDSSEIWQEEVVEGLRNIIEESKNRRPFYELGIQEQLLHIWLLILENCSVEGTESRSIDEKNYERIRCMLSFIQENYARKLELEDIAQHVHICKSECCRIFKNYMKESLFDYILKYRIEQSLPDVLDGKDSLTEIALRVGFADSNYFSKVFHRIKGCSPREYRKRNSMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAV4</accession>
    <name>F7KAV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252884.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02983"/>
    <dbReference type="EnsemblBacteria" id="EGN40303">
        <property type="protein sequence ID" value="EGN40303"/>
        <property type="gene ID" value="HMPREF0994_02983"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3259"/>
    <dbReference type="eggNOG" id="COG4416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133627_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="15676" checksum="BBCDEDDBF98045EB" modified="2011-09-21" version="1">MKEKLIRFMQGRYGVDQFTKFLMGVALVCMILSLFTRSMVWSFLILLLLVYCYFRMFSKSITKRYAENQKYLQMTAGIRRKWASFQRDMKDRKTHHIYKCPGCKQKIRVPRGKGKIAIRCPKCHTEFIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB09</accession>
    <name>F7KB09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252939.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03038"/>
    <dbReference type="EnsemblBacteria" id="EGN40215">
        <property type="protein sequence ID" value="EGN40215"/>
        <property type="gene ID" value="HMPREF0994_03038"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3318"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028794_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07121">
        <property type="entry name" value="ALDH_EutE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012408">
        <property type="entry name" value="Acetald_propionald_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036410">
        <property type="entry name" value="EutE_PduP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="27"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="463" mass="49483" checksum="3FA6411E2514D457" modified="2011-09-21" version="1">MPVSESMVQDIVKEVVARMQLSGSAGTAQHGVFTDMNQAIEAAKEAEAKVRCMTMDQREQIVSNIRRKTHENAELLARMGVEETGMGNVGDKILKHHLLADKTPGTEDITTTAWSGDRGLTLIEMGPFGVIGAITPCTNPSETVLCNSMGMIAAGNTVVFNPHPQAIKTSIFAINMVNEASLEAGGPDNVACTVSKPTLETSNIMMKHKDIPLIAATGGPGVVTAVLSSGKRGIGAGAGNPPALVDETADVRKAAADIVNGCTFDNNLPCIAEKEIVAVDSVADELMNYMISEQGCYLISKEEQDKLTATVITPKGLNRKCVGRDARTLLSMIGIQAPENIRCIVFEGEKEHPLIAEELMMPILGLVRAKDFDDAVEKAVWLEHGNRHSAHIHSKNVDNITKYAKAIDTAILVKNAPSYAALGFGGEGFCTFTIASRTGEGLTSASTFTKRRRCVMSDSLCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB51</accession>
    <name>F7KB51_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252984.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03083"/>
    <dbReference type="EnsemblBacteria" id="EGN40260">
        <property type="protein sequence ID" value="EGN40260"/>
        <property type="gene ID" value="HMPREF0994_03083"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3371"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102878_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="228" mass="24662" checksum="7C5AD97FA1DC8352" modified="2011-09-21" version="1">MSKVYWMVTITGRDQGERFSSMHKSEKIPVILVALGKGTASSEVLDCLGLEESDKIVLFTAVTGDVWKHVKKGMETKLNIDVPGTGISFIVPVSSMGGQKSLRFLLAGQEFEKEEEAVLKDTEYELVIVVSDFGYTNMVMDAAREAGAGGGTVIHAKGTGMEKAEKFLGVSLASEKEITFIVARTEKKKDIMKAVMEKAGMESKAKSIVFSLPVADTAGLRLTGDWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBB3</accession>
    <name>F7KBB3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">HMPREF0994_03142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253043.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03142"/>
    <dbReference type="EnsemblBacteria" id="EGN39972">
        <property type="protein sequence ID" value="EGN39972"/>
        <property type="gene ID" value="HMPREF0994_03142"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3435"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="154" mass="17683" checksum="1A39D4F5B08B3689" modified="2011-09-21" version="1">MSKGKAVENRTEELLAPIAEENGVEIYDVEYLKEGSDWYLRAYIDKPEGVNIQDCENVSRALSDKLDEVDFIDDAYILEVSSPGLGRTLKKDKHLEKSLGEEVELRLYKPRDKQKEFMGILKSFDADSVIIETEEEEKVFARSEIALIRLAFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBD7</accession>
    <name>F7KBD7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">HMPREF0994_03171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253072.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03171"/>
    <dbReference type="EnsemblBacteria" id="EGN40001">
        <property type="protein sequence ID" value="EGN40001"/>
        <property type="gene ID" value="HMPREF0994_03171"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3464"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="183" mass="20947" checksum="9AAC42C29F5E211B" modified="2011-09-21" version="1">MNEKLQQFDTKMTKAYDFLAADFATIRAGRANPHILDKLKVNYYGTPTPIQQVGNITVPEPRMIQISPWEKSLIKEIEKAIMASDVGITPSNDGNVIRLVIPELTEERRKELVKEVKKKGEEGKVAVRNIRRDGNDYFKKLAKEDVSEDEIKELESSLQKLTDKYVKDIDKLVEEKSKEILTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBL9</accession>
    <name>F7KBL9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253157.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03256"/>
    <dbReference type="EnsemblBacteria" id="EGN40086">
        <property type="protein sequence ID" value="EGN40086"/>
        <property type="gene ID" value="HMPREF0994_03256"/>
    </dbReference>
    <dbReference type="GeneID" id="29728278"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3557"/>
    <dbReference type="eggNOG" id="ENOG5030WCJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169484_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="3">
        <location>
            <begin position="167"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="26816" checksum="4A6AB14055685E8F" modified="2011-09-21" version="1">MEEQKNETMETEDMEAADTAADLEETVQQRADGQRTDEEEINEPEADEPGENTRTIPPIHQAGTGYRIGGQLLFKNEFTITKEVYLEFVKAFMGQYRKLYYIMGGVSIILGLFSILGGAFSSGIVFLLVGIICLVMPFFLYKSSRDKKFAKQVANNGGKPLERRISFYSDALEIFSNNGAHSVFEYSAITKIISSKNLYVLVIQKKLSLLVPKDSFVMGNLEEWKVFMMLQGDWKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBN2</accession>
    <name>F7KBN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ech hydrogenase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253170.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03269"/>
    <dbReference type="EnsemblBacteria" id="EGN40099">
        <property type="protein sequence ID" value="EGN40099"/>
        <property type="gene ID" value="HMPREF0994_03269"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3570"/>
    <dbReference type="eggNOG" id="COG3260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="157" mass="16657" checksum="6CCFA6EE172F6A61" modified="2011-09-21" version="1">MKISKSPWLLHYDGSSCNGCDIEVLACLTPVYDVERFGVINTGNPKHADIFLITGGINEQNKPVVQQLYSQMPSPKVVVAVGICACNGGIFKECYNILGGVDTTIPVDIYVPGCAARPEAIIDGVVKAVALLDKKRAEAASHKTADNGQEKPEGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBN5</accession>
    <name>F7KBN5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253173.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40102">
        <property type="protein sequence ID" value="EGN40102"/>
        <property type="gene ID" value="HMPREF0994_03272"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033J8N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195129_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="81" mass="9192" checksum="5E7CF845C787426F" modified="2011-09-21" version="1">MKCLFSCANQYVKESDWKDFALVKLCLCAIGVMIGLAIPKKKKKMPLLIAALVFIATYIPLMTKFLRIVFRKEDDAACECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBP6</accession>
    <name>F7KBP6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253184.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03283"/>
    <dbReference type="EnsemblBacteria" id="EGN40113">
        <property type="protein sequence ID" value="EGN40113"/>
        <property type="gene ID" value="HMPREF0994_03283"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3588"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="29705" checksum="87AC0951E1140BE8" modified="2011-09-21" version="1">MRTGAQLYTVRAYTQNEKDFAFTIKKIADMGYKTVQISAIGRDIKPERVREICEKEGLEIVLTHSDPNRILYDTDRLIEEHNIMGCQYIGLGAMPDKYRTKEWITHFMDDFREPAKKIAAAGKLLMYHNHNFEFQKLPASPDNGADKAKRMIEFLIEGFSAEEMGFTLDTYWVAAAGGDVCQWIELLKDRIPCVHLKDMTVDGFAQQMAPVMEGNLNFPAILKTLENTSCKYILVEQDTCQGSPFDCLKTSYDNLAAAGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBS3</accession>
    <name>F7KBS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253218.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03317"/>
    <dbReference type="EnsemblBacteria" id="EGN40147">
        <property type="protein sequence ID" value="EGN40147"/>
        <property type="gene ID" value="HMPREF0994_03317"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3627"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="455" mass="49070" checksum="38F9ED74B04BBA10" modified="2011-09-21" version="1">MAALDMTKGSITGHLVRYSVPLIVGNLFQLAYNAVDSIIAGRFIGKEALAALGTAGPVMNIIILGISGICMGAGVLMSGFFGAGRHGELKKELSTILLFGLYFSLAVAVCGLFFARPLLSLLRVPDSVLDSACIYLKIIILGAPFTYFYNALAAALKSVGDSGTPVKFLMFASLLNGLLDLIFIGGLGFGIVCSAVTTVAAESVSAVLTWIYIKKRVPLLHPDKENFRIDPALLKKTLRYGGVTALQQACQPVGKLLIQGAVNPLGVDVIAAFQAVNRVDDFAFTPEQSISHGMTTFTAQNLGAEGTREQKTRRIDDGLRTGLMMEFLYWIFIFLVVFLARNVLMKAFISGEGGRNVVELGSRYLKTMAFFYLLPAFTNGLQGYFRGLGKMGITLAGTFIQTSIRVAVTYLTAPVIGIYGVALACAAGWSAMLLFEVPYLIYVRKKRSRLQGEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC13</accession>
    <name>F7KC13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03392"/>
    <dbReference type="ESTHER" id="9firm-f7kc13">
        <property type="family name" value="Tannase_Bact"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39899">
        <property type="protein sequence ID" value="EGN39899"/>
        <property type="gene ID" value="HMPREF0994_03392"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3707"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007377_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="469" mass="52385" checksum="4C74F2D2C816491B" modified="2011-09-21" version="1">MEYDLEFNPDRYRVETAEEEGKRLVYRAYEDLVYVKRPSAPEYQKMNIYIPEAYWEGGSIGAYDRNTAPVFLANTVGGYMPGKPEKPGNNHLGRTNTLFQALLHGYVAVSVGARGRGLTGEDGSFIGCAPACIVDLKAAVRYLKYNRDRICGSMSHIISNGTSAGGALSALLGVTGNHPDYESFLEEAGAACAEDDIFAASCYCPITNLEHGDMAYEWEFNGYDNYQRMHGIRDEKTGERKMVPLTGIQSPEQRKMSDELKILFPAYVNGLHLKDEKGNCLKLEEDGNGSFKEYVKVRVMESIQKAMEEGTDFSGFPWITVRKGKAVDVDFEQYVAYRTRMKTTPAFDEVALTTPENELFGNKTTASRHFTRFSLEHSKAGGAMAEEGQIRRMNPMNYIGDKTCDTAPYFRIRHGASDRDTSLAVSALLAAALREQGIQVDYHLPWGLPHAGDYDLPELFAWIDGICRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC17</accession>
    <name>F7KC17_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03396"/>
    <dbReference type="EnsemblBacteria" id="EGN39903">
        <property type="protein sequence ID" value="EGN39903"/>
        <property type="gene ID" value="HMPREF0994_03396"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3044570_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="54" mass="6433" checksum="5D2A34BF431DBF19" modified="2011-09-21" version="1">MGNFRECIAAVNSREIYDEWLNSGFFTIIREDERTDTRLETMEVLARHFGLIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCQ1</accession>
    <name>F7KCQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253531.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03630"/>
    <dbReference type="EnsemblBacteria" id="EGN39002">
        <property type="protein sequence ID" value="EGN39002"/>
        <property type="gene ID" value="HMPREF0994_03630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3962"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="7">
        <location>
            <begin position="267"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN39002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="807" mass="93528" checksum="D1A6368624EEB6AE" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCT6</accession>
    <name>F7KCT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03665"/>
    <dbReference type="EnsemblBacteria" id="EGN39037">
        <property type="protein sequence ID" value="EGN39037"/>
        <property type="gene ID" value="HMPREF0994_03665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3998"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="33627" checksum="5DF374AC43410007" modified="2011-09-21" version="1">MAEQVKTAKKSRPKSRGINLAVDILIYIFVGLVSLTCVLPYIHVIAKSFSSESFVIAKKVFLLPKGFTPEAYIKIFHDNSFIVSFGVTVLMTVLFTALGMVITICAAYPLSRKELRGRKVINLLFIFTMYFSGGMIPDYILINKLGMLESLPALILPLAFSAYNLVIMKNALESGIPDSLVESAVIDGANHYTILGKIVLPLSKPIMATLTLFYAVGRWNTYSDAMFYIKQNVSLRPLQLKLYYLIVAATESIQGSVNDTAMSTVTDPEILKAACIVFATIPIICVYPFVQKYFVQGTMIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDA7</accession>
    <name>F7KDA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253737.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03836"/>
    <dbReference type="EnsemblBacteria" id="EGN38601">
        <property type="protein sequence ID" value="EGN38601"/>
        <property type="gene ID" value="HMPREF0994_03836"/>
    </dbReference>
    <dbReference type="GeneID" id="29729389"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768729_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="366" mass="41513" checksum="79459C3A3B9B018B" modified="2011-09-21" version="1">MKEIRYLSAEKARKNIEKYSHVYSRNGKIVVTGLCPGQSSYDQVNCVRDRELDFESRLSDYQMSADFAENGLDNVPSISMGFGSVAYLMGIAYGAQPLYMNQLVSAEPIFRSVDDVREFEKIVPVEKHGFYPEICDRIEEFQVKYPEIPIGICDNQSPINVLTSILHSQEAIYAMYDEPEVIHHVMKCITESIMEVNQHLAGIIRNFKGFTAQHFNALPKGMQVSDDNAAFLSPSLYKEFAVPYAEKLAAEFGGLNFHCCRGYEQNLSAIAQVNGFLGFDPQVDFNNIDKILDAVTGRGVWLVNNFKAQQREDRKETDFETFRRIIDQSEGRCSLVIDVWGDTMEEALRLANAVKEYAAKKGRLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE03</accession>
    <name>F7KE03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253983.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04082"/>
    <dbReference type="EnsemblBacteria" id="EGN37118">
        <property type="protein sequence ID" value="EGN37118"/>
        <property type="gene ID" value="HMPREF0994_04082"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4455"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN37118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="30502" checksum="0D77107693C112F0" modified="2011-09-21" version="1">MTFLSYLISGVSLGSIYAIIALGYTMVYGIAKMLNFAHGDVIMVGAYISFCTTSYLGLSPFISVLFSIIVCTALGIVVERLAYKPLRKAPSLAVLITAIGVSYFLQNAALLIWGSSPKTFSSVVGNWSLKLFDGELTISGVTIVTVLACIVIMIALTLFTTKTKTGTAMRAVSEDKGAAQLMGISVNSTISITFAIGSGLAAIAGVLLCSAYPTLMPTTGSMPGIKAFTAAVFGGIGSIPGAMLGGILLGIIEIFAKAYISTQLSDAVVFAMLILVLIVKPDGLLGKHINEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE28</accession>
    <name>F7KE28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254008.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04107"/>
    <dbReference type="EnsemblBacteria" id="EGN36900">
        <property type="protein sequence ID" value="EGN36900"/>
        <property type="gene ID" value="HMPREF0994_04107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_13_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="177" mass="20623" checksum="A3769635750EC7DB" modified="2011-09-21" version="1">MEKTVITKAVSEDIDSISELYDAVNTYFSDNVNYCFPNWQKGKYPVRRDALEALQKDTLFVLKLSGKPEGSFILDNKQHPEYRKIPWGIQCDDKEVMVMHTVVVNPSYRKKGLGEQMITYGINYCRQAGAKTLRLDTHYKNVPARRLYEKCGFRSVTKWSAEIDEVNQEFDVFEYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEB6</accession>
    <name>F7KEB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254096.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04195"/>
    <dbReference type="EnsemblBacteria" id="EGN36475">
        <property type="protein sequence ID" value="EGN36475"/>
        <property type="gene ID" value="HMPREF0994_04195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4576"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363933" evidence="2">
        <location>
            <begin position="27"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="472" mass="51214" checksum="3C2993D8FEE65EE6" modified="2011-09-21" version="1">MKKKLISALLSVAMVSALLAGCGSKAEPESTPAPADTQAEAGSEAEPSEPAESVAETPAASGEGKVYYLNFKPEQAEDWVDLAAVYTEQTGVPVTVVTAASGTYESTLKSEMAKSEAPTLFQVNGPVGLASWKDYCYDLKDSDVYKNIESDDYVLKEGDSVLGMAYVIETYGIIYNKALLNDYFALPDAEITSIDELNNFDALKKVADGIQAHKDDLGVEGAFTSAGFDASSDWRFKTHLANLPVYYEYKADGITSSPAIKGTYLDNYKQIFDLYITDATCEPSLLSGKTGEDAASEFALGEAVFYQNGTWAYNDIKDNEVADEDLGMLPIYIGVEGEENQGLCTGSENYWCVNKNAAPDDIQATLDFLNWVVTSDEGRDALANKMGFVTPFKTFADGYQSTNPLILANDEYTKAGKTPVSWNFTTMPSEEWKNGLGSALLEYAQGTGKWDNVVTAFVDGWKTEYDAANEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEF5</accession>
    <name>F7KEF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN36516">
        <property type="protein sequence ID" value="EGN36516"/>
        <property type="gene ID" value="HMPREF0994_04236"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2167695_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="110" mass="12774" checksum="EB56B46771608B98" modified="2011-09-21" version="1">MNNETIMDNNRNYWNENADLWFGTTALPEYGVKFVTEDDLHLFGNVSGKKLLAYPFTALLNPHYRKKTITFITESQTGNLCSHFPVWLFTHIYLILASHSLRMPAIRAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEY3</accession>
    <name>F7KEY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254320.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04419"/>
    <dbReference type="EnsemblBacteria" id="EGN35729">
        <property type="protein sequence ID" value="EGN35729"/>
        <property type="gene ID" value="HMPREF0994_04419"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4825"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031758_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="38"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="411" mass="46528" checksum="E2A78324517396D5" modified="2011-09-21" version="1">MLIKNIHLENSVECTDIRVSDGVFEKIESGLEALPGEEVIDGTGCMILPPFIESHVHLDTCLTAGDPVWNMSGTLFEGIECWSQRKEKLTKQDVKDRAGRAIRMQAANGVQFVRTHVDVTDPTLVAMEAMLELREELKDEITVQIVAFPQEGILSYPNGKELMENAVKMGADCVGAIPHFEFTREYSVESLNFAMDLAYRYDRLVDVHCDEIDDEASRGLETLAARAYEMQMFDKVTASHTTAMHSYNNAYVNRLMRLLKMSRINFVANPLVNTHLQGRVDTYPKRRGVTRVKELLEAGLNVSFGHDDIFDPWYPLGTGNMRDTVFMGLHVCQMMGYEDIMNSYKLITHNAARTLHLGESYGIREKNPADFIILNGDNFYNALNKKSEILYSFRKGKMLAKTIPAQTEICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF37</accession>
    <name>F7KF37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254380.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN35789">
        <property type="protein sequence ID" value="EGN35789"/>
        <property type="gene ID" value="HMPREF0994_04479"/>
    </dbReference>
    <dbReference type="GeneID" id="29724119"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4892"/>
    <dbReference type="eggNOG" id="ENOG5030F5D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003958_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357334" evidence="2">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="29855" checksum="F81517AB44A003B4" modified="2011-09-21" version="1">MAKKSNGLGRLLAAAAVVGAAAAGTYYYLKNRENSTDREKTGGGEDFDEFDIFDDEDLNDDYSDSISSAADDEHDEAQAHAKGSDTHSSEEHTSDKQGNGRSYVSLDLKKAKEKADALFNDVSEKVEDTVQKIKSSEEYETLSSKVDEAVTKIKNSEEFENVTTKINDTVERIKNSNEYANVDEQMESALNKVKEATEKAVSKVGEKINATMGAAEDMTGKAADAAAQTVHEAAEDVKDAADSAAEKAEDVKDAVENAAEDMADAAADKAEEIKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF94</accession>
    <name>F7KF94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unsaturated rhamnogalacturonyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254351.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04450"/>
    <dbReference type="EnsemblBacteria" id="EGN35760">
        <property type="protein sequence ID" value="EGN35760"/>
        <property type="gene ID" value="HMPREF0994_04450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4860"/>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043688_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="363" mass="42366" checksum="5164D4887703291F" modified="2011-09-21" version="1">MLQEVDRKLRQLIGAFTSILYEDDDIFMEKMRRKKNLSEEELQKYAHWEWTQGVGLYGIWKLFAASGEKEYLEILTRYYDRQQQVGFPQCNVNTVTPYLTMSYLAEYLQSEVYMKPCQEAAEWVMYQMPRTREGGIQHMTSDDVNEQELWDDTLVMTVLFLANMGRILDREDYRNEAQYQFMVHMKYLQDPKSGFWYHGWTFLERNHFAGAFWGRGNCWITIAIPELLSSIPCSEPVERILKEALCNQVEALAECQAESGMWHTLLDDPESYEEASATCGFAYGILRGVHCGLLEEKWLEAAERVLKPVLALISEEGVLGQVSYGTPMGRENREFYKEIPLRPMPYGQALAILFLVEWKKGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFC3</accession>
    <name>F7KFC3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35321.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359944.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04552"/>
    <dbReference type="EnsemblBacteria" id="EGN35321">
        <property type="protein sequence ID" value="EGN35321"/>
        <property type="gene ID" value="HMPREF0994_04552"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35321.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="33666" checksum="530BE74D2F29FB58" modified="2013-09-18" version="2">MKKKKTSLGDWIFNIFLGLFFTLFTLICIYPFYYLIINTISANDISANGQIMFLPKGIHFQNYIDVFKIPDLASAALVSLGRTVLGTIGAVLGAAYLGFMFTQQKMWARKFWYRFTIITMYFNAGLIPWYITMRNLHLTNNFLAYILPAIVQPFNIILVKTYMESISPALQEAAEIDGASVMKVFMKIMLPLAKPIMATIAIFAAVGQWNSFQDTLILMTKPALYTLQFLLYQYINQASSLAAMIKNGTVISTSSLATMQTPTSIRMTVSVVVILPILLVYPFFQKYFVKGIMIGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFF7</accession>
    <name>F7KFF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254487.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04586"/>
    <dbReference type="EnsemblBacteria" id="EGN35033">
        <property type="protein sequence ID" value="EGN35033"/>
        <property type="gene ID" value="HMPREF0994_04586"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5005"/>
    <dbReference type="eggNOG" id="COG2426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075669_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009577">
        <property type="entry name" value="Sm_multidrug_ex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36007">
        <property type="entry name" value="PTHR36007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06695">
        <property type="entry name" value="Sm_multidrug_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="166" mass="18185" checksum="F87D8DBD3665724F" modified="2011-09-21" version="1">MDSIALWFASTLGQYVSKEVVIFIISMIPILELRGGLLVAWSLGVPILKAIPICIIGNIIPIPFILLFIKKIFQLLKKVPFFEKIIGKLENRAMKKSDNIKKYEFWGLVLFVGIPLPGTGAWTGSLIAALLEVDFKKAVLAELLGIILATIIVSFVSYGLLGSIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFK4</accession>
    <name>F7KFK4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254534.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04633"/>
    <dbReference type="EnsemblBacteria" id="EGN35080">
        <property type="protein sequence ID" value="EGN35080"/>
        <property type="gene ID" value="HMPREF0994_04633"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5059"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="32641" checksum="A649398CB8DDECD1" modified="2011-09-21" version="1">MNSKSEKNDLLQRYKEELIENEKSEATVIKYMREVNLLLDYLEGHERNKASILDYREALKKNFQAQTVNVKLAAIHSFLEFCNKPEWKVKFLKVQRRAFADEARELTEKEYRVLLDTAKRRKKNRLYFVMLTLGGTGIRISELPYITLEAVKKGKAEISMKGKNRIILIPKCLKEKLLAYASQCGIKNGSLFQSRNGKPLNRSNIWRELKRLCGEAAVNPEKVFPHNFRHLFAKCYYAIEKDIAHLADILGHSSVETTRCYIAVSYKEHEETLTRLRLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFL9</accession>
    <name>F7KFL9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_04648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254549.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04648"/>
    <dbReference type="EnsemblBacteria" id="EGN35095">
        <property type="protein sequence ID" value="EGN35095"/>
        <property type="gene ID" value="HMPREF0994_04648"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5077"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="10">
        <location>
            <begin position="61"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="8">
        <location>
            <begin position="172"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="9">
        <location>
            <begin position="279"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="11">
        <location>
            <begin position="630"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="12">
        <location>
            <begin position="702"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="808" mass="90344" checksum="CCA02B67DE41AC85" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFR8</accession>
    <name>F7KFR8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">HMPREF0994_04697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254598.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04697"/>
    <dbReference type="EnsemblBacteria" id="EGN34623">
        <property type="protein sequence ID" value="EGN34623"/>
        <property type="gene ID" value="HMPREF0994_04697"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5127"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="3"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="357" mass="38936" checksum="D9B4F89DAF2AF2E4" modified="2011-09-21" version="1">MIRIGMLTSGGDCQALNAAMRGVAKTLFNAKEEVEIYGFLDGYKGLIYGKFRMLTSSDFSGILTKGGTILGSSRMPFKLMRDPDENGLNKVEAMKQNYHKLQLDCLVILGGNGTHKTANLLKEEGLNVITLPKTIDNDLWGTDMTFGFQSAVNIATEAIDNIHTTAASHGRVFIVEVMGHKVGFLTLNAGMAGGADLILIPEIPYDIDKVIAAIKERHDRGSRFTILAVAEGAISKEDAKLSKKEYKKKLENYTFPSVSYELADQIAKKSGMEVRVTVPGHTQRGGTPCPYDRVFASRLGSEAGKLILKGEYGFMVGYKNREIVKVPLEEVAGKLKMVDPNSSIVKEAKMLGISFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFV9</accession>
    <name>F7KFV9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254639.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04738"/>
    <dbReference type="EnsemblBacteria" id="EGN34664">
        <property type="protein sequence ID" value="EGN34664"/>
        <property type="gene ID" value="HMPREF0994_04738"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5171"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="302"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="577" mass="65775" checksum="CB4A8EAF2C71A851" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG53</accession>
    <name>F7KG53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254733.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04832"/>
    <dbReference type="EnsemblBacteria" id="EGN34459">
        <property type="protein sequence ID" value="EGN34459"/>
        <property type="gene ID" value="HMPREF0994_04832"/>
    </dbReference>
    <dbReference type="GeneID" id="29727835"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5273"/>
    <dbReference type="eggNOG" id="ENOG50337AI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_770904_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="323" mass="38399" checksum="78ED772C8E8E72F5" modified="2011-09-21" version="1">MYLDILEELLENQAQLYKNAYKGDFSQVCYLEAKDKEHGTYDKNYTNRLRLSYFLLYKHINNEDIVKRLFEEELKDRETNSFQGIGSALEILTFLLMKYNREGTYDSLFERAKTANFDCACGYTPNVEISSELEDCDIYDGISIAIDMGCMESARKLVKLWKEDVACWDKRNYERLIYFNKDIKREEENEEPLKALAEIARAKGKNSDIISTLRSLLHYYIQFDKKEQAYDCFQQLIREGDLTEIYHIRLFEYILEDCMELICEYKEKAEELWKWARPFIIERAGNMFGNLYKKSILAAETVNDDFSGELNYQYQEWKKRVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG79</accession>
    <name>F7KG79_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04862"/>
    <dbReference type="EnsemblBacteria" id="EGN34489">
        <property type="protein sequence ID" value="EGN34489"/>
        <property type="gene ID" value="HMPREF0994_04862"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5305"/>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="64"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="34521" checksum="4A5F31C51BD17D65" modified="2011-09-21" version="1">MENRVTEFEQIMKDCTLCPRNCHADRLGGRRGYCGQGAEIMAARAALHFWEEPCISGETGSGTVFFSGCVLRCVYCQNHNIAESRAGRIIGWERLSEIFLELQDKKANNINLVTPTHFVPQIALALERAKLGGLHIPVVYNTGSYERVETLKRMEGLVDIYLPDLKYMSSRLGERYSHAADYFETASAAVAEMVRQTGEPDFDDKSGLMKKGVIVRHLVLPGCTADSKKVISYLYHTYGDRIYISIMNQFTPVCDLSSFPELNRRITAREYEKIVDYALDIGVENGFIQEGNTAEESFIPEFDGEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG85</accession>
    <name>F7KG85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04872"/>
    <dbReference type="EnsemblBacteria" id="EGN34499">
        <property type="protein sequence ID" value="EGN34499"/>
        <property type="gene ID" value="HMPREF0994_04872"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5315"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080975_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="31072" checksum="5C709BF0EA69B700" modified="2011-09-21" version="1">MVKEGMKNIYICFPEGKHKVLTMSFDDGRLEDRRLVDIFNRYGIKGTFHVNSAIRDEKKVPVSEYRELYKGHEVSCHTCTHPTIARCPMEQVVSQILEDRRNLEAAVGYPVRGLSYPNGSYNEEIVKILPALGIRYSRTVEETNGFAMPEDFLKWKATCHYNHNLIKLGDEFAALHKTQYLYMMYVWGHSYEFTDHDNWEVMENFCRRMGGREDIWYASNIEIVDYMEAAGRLQFGAGGDMVYNPSAASLWIEVDGGKREVKGGQLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGG0</accession>
    <name>F7KGG0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04939"/>
    <dbReference type="EnsemblBacteria" id="EGN34108">
        <property type="protein sequence ID" value="EGN34108"/>
        <property type="gene ID" value="HMPREF0994_04939"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5393"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="524" mass="60539" checksum="D3006B6E2FA03DC1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGJ4</accession>
    <name>F7KGJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04973"/>
    <dbReference type="EnsemblBacteria" id="EGN33768">
        <property type="protein sequence ID" value="EGN33768"/>
        <property type="gene ID" value="HMPREF0994_04973"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5432"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="119" mass="13169" checksum="113A986696DCAFE1" modified="2011-09-21" version="1">MNSADVPIYEQIKNQIKAAILAGELEEGDVLPSVRNLARDLNCSVITTRKAYEGLEAEGFTINMAGKGSFVAPQNMELLRETRLAEIERKLTDIMEYARPVGITGADLKTIIDELSRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGR5</accession>
    <name>F7KGR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron(III) transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254945.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05044"/>
    <dbReference type="EnsemblBacteria" id="EGN33753">
        <property type="protein sequence ID" value="EGN33753"/>
        <property type="gene ID" value="HMPREF0994_05044"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5510"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="59"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="340"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="546" mass="60467" checksum="170D59C705F7654B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH58</accession>
    <name>F7KH58_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006776319.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05194"/>
    <dbReference type="EnsemblBacteria" id="EGN33227">
        <property type="protein sequence ID" value="EGN33227"/>
        <property type="gene ID" value="HMPREF0994_05194"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5673"/>
    <dbReference type="eggNOG" id="ENOG502ZHJM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259627_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="183" mass="21704" checksum="8856D7DE112D307E" modified="2011-09-21" version="1">MRDYSSQKIEIETIKPRTITVNLSNADVKRLAEKSGEGGLTISELLENFIGDLVDGTYSNGSDERMYAEQWYQRCWFAMFSDDTFLKFLLLWGDLDDYIDLMDELESNKKEMAEMTADAEEYSAEERDELQEYINELQKEIDYYWGKFLERKRQKESYVFEKEIENIMAWKSQLDTILDPENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH70</accession>
    <name>F7KH70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4261 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862355.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05206"/>
    <dbReference type="EnsemblBacteria" id="EGN33239">
        <property type="protein sequence ID" value="EGN33239"/>
        <property type="gene ID" value="HMPREF0994_05206"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5684"/>
    <dbReference type="eggNOG" id="ENOG502Z7PZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056940_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025357">
        <property type="entry name" value="DUF4261"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14080">
        <property type="entry name" value="DUF4261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4261" evidence="1">
        <location>
            <begin position="202"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="292" mass="33380" checksum="E40E7DBD093B80FB" modified="2011-09-21" version="1">MSNKAFQQNLDDKKGPQPGGPYLIQMLFKEPVEMPDKEKMTAIMEKHIGSTECFCYDKKMAGFAALDHVAEFQDGKYPVQLMVMKCDKFKGKGFDAFLMSQMWDCQEDRDRIFRECKYQVVATDMLTAALPALERANLDADFLEALAELYPTCEAFYFQNCGKLFLAEDVRSHQIEGPDRFIRFGVNVRFFNIEGTEDMLIDTVGMSTLFLPDLQYHFHGMDPNWVVNHAYNAASYILEHDNPIQDGETIDGVADSQMCREVQWKCQYEDSLIQPPRGVLDINMGNYASGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHB9</accession>
    <name>F7KHB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005930789.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05258"/>
    <dbReference type="EnsemblBacteria" id="EGN33291">
        <property type="protein sequence ID" value="EGN33291"/>
        <property type="gene ID" value="HMPREF0994_05258"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5744"/>
    <dbReference type="eggNOG" id="ENOG50303P7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2551535_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="82" mass="9628" checksum="405F8027349125F1" modified="2011-09-21" version="1">MKMNRNEMEALYAFGCPNLKATVERLRMVAALAPDPVAKKLFYMLSVKLSAEGVERWYRCFYCKLRVLKNHREGCYDETDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHE9</accession>
    <name>F7KHE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal bacterial protein YeaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255121.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05278"/>
    <dbReference type="EnsemblBacteria" id="EGN33013">
        <property type="protein sequence ID" value="EGN33013"/>
        <property type="gene ID" value="HMPREF0994_05278"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5763"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="289" mass="30956" checksum="D2E33FCD49EE77A0" modified="2011-09-21" version="1">MKILAIDSSGLVASVAVTEDDNLIAEYTTNYKKTHSQTLLPMLDEVKKMIELDLNTIDAIAVSAGPGSFTGLRIGSATAKGLGLALNKPLIGVPTVDALAMNLYGTDQIICPLMDARRSQVYTGIYRFVQESGNEAAAPASLPDAAQAQAFGEVSYSLKVREPQCVVPIEEIAERLNQLPEDVGVIFLGDGVPVFRSRLAELMRRPYSFAPALCNRQRASAVAVLAAGYAKEGKMVSADAFVPEYLRPSQAERERSEARKLAGAQAGDAMMRKGTFSKEKKAIPEESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHS3</accession>
    <name>F7KHS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255255.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05412"/>
    <dbReference type="EnsemblBacteria" id="EGN32853">
        <property type="protein sequence ID" value="EGN32853"/>
        <property type="gene ID" value="HMPREF0994_05412"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5915"/>
    <dbReference type="eggNOG" id="COG1929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028255_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="386" mass="40648" checksum="2B09DE965B837FFE" modified="2011-09-21" version="1">MKKVVLIPDSFKGTLSSAKVCEIMSKCIHNKFPDCEIVQIPVADGGEGTVDCFLQAVGGQKRSVTVCGPFMERIESFYGIPDTGDKTAVIEMAACAGLPLAEGRENPELTSTYGVGELIADALEQGCRNIIIGLGGSSTNDGGCGMAAALGAKFYGEDGEAFLPVGGTLKNIKRIDISGLDRRLKQTCITAMCDIDNPLYGANGAAFIFGPQKGADPAMVDRLDAGLRCLSRQILTDLGTDVSELPGAGAAGGMGGGAAAFLHARLCPGIEVVLETVRFEERIEGADVIFTGEGRLDYQSLMGKVVGGVAKYAKRDGIPLIVVAGSIDERTGDIYGSGVSAAFSITRMPVPFTEARKSSEENLERTMEDILRLWKVIDEEYAGAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHV4</accession>
    <name>F7KHV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255286.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05443"/>
    <dbReference type="EnsemblBacteria" id="EGN32884">
        <property type="protein sequence ID" value="EGN32884"/>
        <property type="gene ID" value="HMPREF0994_05443"/>
    </dbReference>
    <dbReference type="GeneID" id="29727524"/>
    <dbReference type="HOGENOM" id="CLU_602323_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021359">
        <property type="entry name" value="DUF2812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11193">
        <property type="entry name" value="DUF2812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="437" mass="50409" checksum="C80171464A7DB3F6" modified="2011-09-21" version="1">MKRSEKVVKNIPADFTNPDRAERWLEENAEQGLVLIRYSGRKAVFIKGEPAKTAYMVVPMDPDGMKGPRDQGEEYKEFGWEYVTQLGRMVLILRGMPGKCERVQLLAGDTLFKKLRKKQRGRIWGLFSPFIFWLIWFLFFYFFQGYGFLLLFAKGVAWLIFLAMGVGGLLQMWSFREARVADGLLEGIRNRFVLENPSDGNRKDGAGTSVQKKRRGTGNPPGLLYRVLSIIFLISLVLGMAGGIHYGAGRIRSVYTGKVSEAGWDESDFRTRAFLDKYPSWKEISPVLLPLSRLEEQPEMEYQTLDYRGEKLENYSSINRFPFAPIQAETMQYGIWNSGDGTRESTLKLEYYRLASPKLAAPLMRELGRYYMNWNKGWMPQRVASGCFDELVIHDRGLHYLFARKDNQVLMAYYIGEENLEDHLPELEEMMDMLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI11</accession>
    <name>F7KI11_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571034.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05513"/>
    <dbReference type="EnsemblBacteria" id="EGN32954">
        <property type="protein sequence ID" value="EGN32954"/>
        <property type="gene ID" value="HMPREF0994_05513"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6027"/>
    <dbReference type="eggNOG" id="ENOG50315TI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179097_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="93" mass="10879" checksum="0283A703C75F9767" modified="2011-09-21" version="1">MKLSLYEQETILLYNQAEDTAEVYTHDRKLMEKLTRLSKKHPEQVCKKDKHNFTVPKRCVSVREPYSAERRKAASERAKAAGYRPPVRKADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIA5</accession>
    <name>F7KIA5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05584"/>
    <dbReference type="EnsemblBacteria" id="EGN32409">
        <property type="protein sequence ID" value="EGN32409"/>
        <property type="gene ID" value="HMPREF0994_05584"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6101"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="428"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="533" mass="62093" checksum="D8403602CD8C4938" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIE4</accession>
    <name>F7KIE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05623"/>
    <dbReference type="EnsemblBacteria" id="EGN32334">
        <property type="protein sequence ID" value="EGN32334"/>
        <property type="gene ID" value="HMPREF0994_05623"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6143"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="317" mass="35246" checksum="C3C38B0EB33D5089" modified="2011-09-21" version="1">MKLINKAGKSQGKTGTAGISWKREFHRNLPLYMLVLPAAILAIIFCYIPMAGLIMAFQNYKPWLGIFGSEFAGLDNFRQIFEFRESYQAIINTLIIAVSKIVLGLIVPVIMALLLNEVKQLGLKKSIQTLVYLPHFLSWVTVAGMLRDILGLDGIINVFLQKIGMEPVFFLGEAGMFRQIAVLSDLWKGFGFGMIVYLAAISNIDQNLYEAAEMDGANKWQQTLHITLPGIMPMVIVMATLSLGNVLNAGFDQIFNLYSPLTYSTGDIIDTYVYRQSLVNGQYSFGTAVGLFKSGIGLLLTVAAYKIAYRFAGYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJA2</accession>
    <name>F7KJA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05942"/>
    <dbReference type="EnsemblBacteria" id="EGN31570">
        <property type="protein sequence ID" value="EGN31570"/>
        <property type="gene ID" value="HMPREF0994_05942"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6503"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002552_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356966" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="548"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="639"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="1571"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="921"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1877" mass="206813" checksum="2D52BF9DAF3E3517" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJI0</accession>
    <name>F7KJI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255788.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06012"/>
    <dbReference type="EnsemblBacteria" id="EGN31366">
        <property type="protein sequence ID" value="EGN31366"/>
        <property type="gene ID" value="HMPREF0994_06012"/>
    </dbReference>
    <dbReference type="GeneID" id="29724846"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6582"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076888_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027839">
        <property type="entry name" value="DUF4432"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14486">
        <property type="entry name" value="DUF4432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="34761" checksum="047E90DC185130DF" modified="2011-09-21" version="1">MYILENDKLAVHVLPELGGKITSLYLKEKEFELAAPNRTGQYRLPGGDAQTGKKTDFGPDFSRYDASGLDDAFPNIDPGLVEWQGRKLYYPDHGEIWSHMMELQEMPEGIRLSYASAAFGYAYEKRMELKGSSLSLHYRIENRGGGEFPFLWTFHGLMRYEEDMRLLLPTDFEYYRNVLSHPVLGEEGRIYPARNDIYDFSRVPAPESKSMVKYYGEGKSREGTCGLWYPSRGVRCMLRYDAQALPYLGVWITAGGYRGDCNCALEPSTGFYDGISRARENGSLKVIKPGEIFSFTLEICLENTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJT8</accession>
    <name>F7KJT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN30743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255893.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN30743">
        <property type="protein sequence ID" value="EGN30743"/>
        <property type="gene ID" value="HMPREF0994_06117"/>
    </dbReference>
    <dbReference type="GeneID" id="29725669"/>
    <dbReference type="HOGENOM" id="CLU_2666431_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="75" mass="8862" checksum="725A5D0DB2401022" modified="2011-09-21" version="1">MLMEQYPVALRNHINALNFDLELWSAWKMARLALQILGQKSLDEEFLAVSERQDNSDGTFLLERSNIILQRLWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKC6</accession>
    <name>F7KKC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30224.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06305"/>
    <dbReference type="EnsemblBacteria" id="EGN30224">
        <property type="protein sequence ID" value="EGN30224"/>
        <property type="gene ID" value="HMPREF0994_06305"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="406"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN30224.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="503" mass="57727" checksum="22D9AE7CB2FFBF3A" modified="2013-09-18" version="2">MRLLIADDESLIREAIMARLKKGRYEFEEIYQAGDGLEAWAIAKNERPEIIITDVRMDGMSGLSLIQSCQTAGINSSIIVISGYAEFDYVQNAMYHGACCYLLKPITQETLFDALNKAIEKNTTLTKYTRVQEQNTLLLLNQLLQKARDHSLNDTEYSQLLSLLGADKDWEFIVGSAHVSRYDQSRYFSIENVYSILADSLSPRLPSAFRLLPGPNTPDRILLFSAPSLQSLQKQIYETLDSQIMKLNVLGAIITLGLSPISRSLSPELFDQSEQALKHRFLTGNGKIYHMEDPSADTGQLPSSLDWKNLENELRCKSPQDTAEKLCSLIDSFYPLVHNFEYLIQYIYELLIRLNYTPSKKSWDHFTDNRFWSSHENREEILSLIKEEISLTCRTKPAEGSQSVTEQAKNFLKEHYREPISMEMLAEYFHLNPRYFSTVFKKKEGLSPIDYLTQVRMEAAKSTLRNTDIPASEIAALVGYEDPRYFYKVFKKYTGLTPTEYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKD7</accession>
    <name>F7KKD7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN30175.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06316"/>
    <dbReference type="EnsemblBacteria" id="EGN30175">
        <property type="protein sequence ID" value="EGN30175"/>
        <property type="gene ID" value="HMPREF0994_06316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088563_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30175.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="160" mass="18287" checksum="BB01BA96BBCFFE8A" modified="2013-09-18" version="2">MPTSYLMQMHSSYVVTDPKGTILVECGKMLQRGTSKLGKDGKPMKDKHGKVIYEPYRIKVLNTINFKKSMHYNPFAYIHSEKDILKLVTTLIANTKGEGKAGDDFWVKAETLLYCALIGYIHYEAPVEEQNFSTLIEFINAMEVREDDEEFKNRATLIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKE8</accession>
    <name>F7KKE8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="8" type="ORF">HMPREF0994_06327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256089.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06327"/>
    <dbReference type="EnsemblBacteria" id="EGN48106">
        <property type="protein sequence ID" value="EGN48106"/>
        <property type="gene ID" value="HMPREF0994_06327"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6930"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN48106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="14589" checksum="9CA7C9A30C241B1D" modified="2011-09-21" version="1">MANAAKYYGTGRRKKSIARVYLVPGKGDITINKRPIDEYFGLETLKVIVRQPMAATDTDGKFDVLVNVKGGGYTGQAGAIRHGIARALLEADSEFRPTLKKAGYLTRDPRMKERKKYGLKAARRAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKF3</accession>
    <name>F7KKF3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell membrane</location>
            <topology evidence="2 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256094.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06332"/>
    <dbReference type="EnsemblBacteria" id="EGN48111">
        <property type="protein sequence ID" value="EGN48111"/>
        <property type="gene ID" value="HMPREF0994_06332"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6935"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030946">
        <property type="entry name" value="EcfA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04521">
        <property type="entry name" value="ECF_ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN48111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="31257" checksum="8044A988245E7766" modified="2011-09-21" version="1">MAIKLEHVNYIYGADTELSVAALKDVNLSIEDGQFIGLIGHTGSGKSTLVQHLNGLLKATSGAIYYNGKNIYDKDYNMKELRSKVGLVFQYPEHQLFEIDVFSDVCFGPKNLGLSKEEIQARAMEALELVGIGEEYYKQSPFDLSGGQKRRVAIAGVLAMKPDMLVLDEPTAGLDPKGRDEILGEISLLREKTGMTIVLVSHSMEDVANYVNRIIVMNKGSVMFDDEPKKVFAHGKELEAVGLAAPQVTYIMQTLKEAGLAVETDATTLTEARDSILAACGHGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKJ7</accession>
    <name>F7KKJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplB</name>
        <name evidence="8" type="ORF">HMPREF0994_06376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256138.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06376"/>
    <dbReference type="EnsemblBacteria" id="EGN47984">
        <property type="protein sequence ID" value="EGN47984"/>
        <property type="gene ID" value="HMPREF0994_06376"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6978"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="7">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN47984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="30452" checksum="90DC4A39DC02DCB0" modified="2011-09-21" version="1">MGIKTYNPYTPSRRNMTGSDFSEITKSTPEKSLCVSLKKNAGRNNQGKITVRHRGGGNRRKYRVIDFKRYKDDVPATVIGIEYDPNRTANIALICYADGEKAYILAPEGLKDGMKIMNGPHAEVRIGNCLPLSEIPVGTQVHNIELYPGKGGQLVRSAGNGAQLMAKEGKYATLRLPSGEMRMVPVICRATVGVVGNGDHNLINIGKAGRKRHMGIRPTVRGSVMNPNDHPHGGGEGKTGIGRPGPSTPWGKPALGLKTRKKKNKSNKLIVRRRDGKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKW8</accession>
    <name>F7KKW8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256259.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06497"/>
    <dbReference type="EnsemblBacteria" id="EGN47508">
        <property type="protein sequence ID" value="EGN47508"/>
        <property type="gene ID" value="HMPREF0994_06497"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7115"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="315" mass="35671" checksum="D150DAD4CA99EE66" modified="2011-09-21" version="1">MRYKHFKNADVKVSCLAVGTWAIGGKNYGPVDREGSIRAIRRMVDLGVNLIDTAPCYGNGTAEKIVGEAIRTIPRDKILLSTKFGLVPDVFKGDFRKEATYKNAMREVESSLMNLDTDYIDFYFVHWPDVNTPICETMSALADLKRMGKIRYVGVSNFTQEQIEEAEKYLTVDVQQPPFSMVERQYEQLMSWGASRGIDSMTYGSMGAGILSGKYRDTPDFEPGDLRLTFYDYFREPKFSKIQELLKTMDEIAGEHNCPVSQVALNWSTQKDFVGTALVGVRSEAHADENCVAFEWELSEAEILRLDNELERLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL49</accession>
    <name>F7KL49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">M3 family oligoendopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256344.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06582"/>
    <dbReference type="MEROPS" id="M03.010"/>
    <dbReference type="EnsemblBacteria" id="EGN47301">
        <property type="protein sequence ID" value="EGN47301"/>
        <property type="gene ID" value="HMPREF0994_06582"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7206"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030403_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011976">
        <property type="entry name" value="Pept_M3B_oligopep-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02289">
        <property type="entry name" value="M3_not_pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="165"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="310"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="560" mass="66737" checksum="E6660D1020372728" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLC7</accession>
    <name>F7KLC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="15" type="ORF">HMPREF0994_06656</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256409.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06656"/>
    <dbReference type="EnsemblBacteria" id="EGN46580">
        <property type="protein sequence ID" value="EGN46580"/>
        <property type="gene ID" value="HMPREF0994_06656"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7279"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="14">
        <location>
            <begin position="71"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGN46580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="255" mass="28286" checksum="0A9ED3EBBBA8FF06" modified="2011-09-21" version="1">MKIQEIKEQFGNCPTERLPELIEAYKEDERSGIKAEIAKAEKRLEALEKEKARMFTMLRFEREYGDAGYICGIDEVGRGPLAGPVVAGAVILPKDCSILYLNDSKQLSARKREELYEVIMKEAVATGIGYASPERIDEINILQATYEAMREAVSRLCVKPDILLNDAVTIPGLPMRQVPIIKGDAKSASIAAASIIAKVTRDRMMVQYDSVFPGYGFEANKGYGAAAHIDALKRLGPTPIHRRSFIKNFMEGANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLE6</accession>
    <name>F7KLE6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256429.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06676"/>
    <dbReference type="EnsemblBacteria" id="EGN46600">
        <property type="protein sequence ID" value="EGN46600"/>
        <property type="gene ID" value="HMPREF0994_06676"/>
    </dbReference>
    <dbReference type="GeneID" id="29723706"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160219_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="31"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="222" mass="25252" checksum="3827AA6550577AFE" modified="2011-09-21" version="1">MLADKCSYLYNETRDLEKEWPDNKSLDIVCHGHSIPCGYMAGNITMPFAAYPHILHQKLAERFPHSVINIIVTAKGGENSLEGSLRFKEDVLCHRPGIITLDYGRNDMFLEKTQIEYSWRQMIEYALKAKCKILLITPAPDCGSIYYETGTKKTDDEAIAEIIRELAEYYEVGLADVKMAFDLKFGAGHCRSEYLASVNHPNKTGHEIIAGCLMEWFPFICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLL5</accession>
    <name>F7KLL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256445.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06692"/>
    <dbReference type="EnsemblBacteria" id="EGN46616">
        <property type="protein sequence ID" value="EGN46616"/>
        <property type="gene ID" value="HMPREF0994_06692"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7319"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="174" mass="19601" checksum="CE3212E0AD34890D" modified="2011-09-21" version="1">MLINMTDVFTEEEKSVVKEVPLELTSICFQGEDFRILEKSPVTLTLTNTGQGRASIEAEVAVKVELKCDRCLREVTKEFTLQFSAQAVSPDVADEQEQDEERGFLEGYQLNVDSLISNEIITCWPMKILCKEDCKGLCSVCGKDLNEGKCDCDTFVPDPRMAAIMDIFRENKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLQ7</accession>
    <name>F7KLQ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06786"/>
    <dbReference type="EnsemblBacteria" id="EGN46378">
        <property type="protein sequence ID" value="EGN46378"/>
        <property type="gene ID" value="HMPREF0994_06786"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="328"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="431" mass="49639" checksum="3A245B59AB72C754" modified="2011-09-21" version="1">MYRVLVVDDEEMITDSLAGMLEETPQYELDVYKAYSGTEALRLLNEFQFDIVVSDICMPGITGIELAKNIRQKWPLCHVIFQTGYDDFHYAQQAIRQRVTHYILKSEGDEFLLEAIGECIRTIERDMDMQDTLLKTKEETRLYKAMLRRNMVQTLLFDQSKRTSHRDRAYEKVEIDLNLSLPVMLLAGRSAQELTEETALAIDLAMQEKISYAVKSEAAWMDKHVIMWALQPVETENLRHAQAVVKGMAEGIQRTIRQMLGISISFVFREKQIDWEHVSQPFEELKHIAANRLRADSQIAMAGIEYFEEEGGAAGGQNEAELEKSFVSRLMAYMTEHIDGDLSLCTLSEKLHLNPSYLSRRFKELTGRTLTEVILRIRMETACELLKTTSYRISEIAQMVGYETAANFSKVFKKAMKMTPREYRDGEGTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLT9</accession>
    <name>F7KLT9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MobC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN46235.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002594236.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06818"/>
    <dbReference type="EnsemblBacteria" id="EGN46235">
        <property type="protein sequence ID" value="EGN46235"/>
        <property type="gene ID" value="HMPREF0994_06818"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBKZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096411_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46235.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="14616" checksum="9229F2CCA40E9FA8" modified="2013-09-18" version="2">MKRYNTPHRSRVVKTRMTEEEYAEFAQRLSAYHMSQAEFIRQAITGAAIRPIITVSPINDELLAAVGKLTAEYGRIGGNLNQIARTLNEWHSPYPQLAGEVRAAVSDLAALKFEVLQKVGDAVGNIQTYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRM2</accession>
    <name>S2KRM2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_07243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360208.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07243"/>
    <dbReference type="EnsemblBacteria" id="EPC05094">
        <property type="protein sequence ID" value="EPC05094"/>
        <property type="gene ID" value="HMPREF0994_07243"/>
    </dbReference>
    <dbReference type="GeneID" id="29728182"/>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009096_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="1"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="655"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="770" mass="87413" checksum="9CD3FBEDE962B399" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSJ4</accession>
    <name>S2KSJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359947.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07096"/>
    <dbReference type="EnsemblBacteria" id="EPC05247">
        <property type="protein sequence ID" value="EPC05247"/>
        <property type="gene ID" value="HMPREF0994_07096"/>
    </dbReference>
    <dbReference type="GeneID" id="29724164"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004510174" description="DUF3502 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="2">
        <location>
            <begin position="415"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="550" mass="61011" checksum="76DF44D345129847" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJP9</accession>
    <name>S2LJP9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_07174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571029.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07174"/>
    <dbReference type="EnsemblBacteria" id="EPC05178">
        <property type="protein sequence ID" value="EPC05178"/>
        <property type="gene ID" value="HMPREF0994_07174"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012396_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="438"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="577" mass="64021" checksum="0ED16E4B1BC7E07C" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2X5</accession>
    <name>F7K2X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00204"/>
    <dbReference type="EnsemblBacteria" id="EGN39237">
        <property type="protein sequence ID" value="EGN39237"/>
        <property type="gene ID" value="HMPREF0994_00204"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2130255_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="12685" checksum="E3DE4415D76CCC32" modified="2011-09-21" version="1">MTSQESCCKIVDFQEYLGKKELELQMKQIVNREIMVIVPTQLSQIVSVGKKLLLGETVILNLNYLDAETTQRFMDFVCGICYTVNGILTCISAGIYIASVDDYIDTAMTESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3B4</accession>
    <name>F7K3B4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="12" type="ORF">HMPREF0994_00347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250296.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00347"/>
    <dbReference type="EnsemblBacteria" id="EGN33488">
        <property type="protein sequence ID" value="EGN33488"/>
        <property type="gene ID" value="HMPREF0994_00347"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.375"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_0_9"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN33488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="44091" checksum="E7F617985F04A76D" modified="2011-09-21" version="1">MAKEMIAMLLAGGQGSRLYALTQKLAKPAVPFGGKYRIIDFPLSNCVNSGIDTVGILTQYQPMVLNEYIGNGQPWDLDRLHGGVHVLPPYQKASGSDWYKGTANAIYQNIPFIERYDPEYVIILSGDQICKQDYSDFLRFHKEKGAEFSVAVMEVPWEEASRFGLMVADENDKITEFQEKPKKPKSNLASMGIYIFNWDVLKKYLMEDEADPDSENDFGNNIIPSLLRDGREMYAYHFSGYWKDVGTIASLWEANMEVLDPEHSGINLFDDNWKIYSRNSGMTGHKIASGAIVENSMITDGCRIGGHVKHSVLFAGVIVEPGAKVEDAVVMGGTVIKAGAVVEHCIIAENVVIGENAVVGAMPEGDSTGVATVGSGVYIGAGAKIGPDAMIEQNVKDGEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3U3</accession>
    <name>F7K3U3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fliQ</name>
        <name evidence="10" type="ORF">HMPREF0994_00522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250471.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00522"/>
    <dbReference type="EnsemblBacteria" id="EGN45526">
        <property type="protein sequence ID" value="EGN45526"/>
        <property type="gene ID" value="HMPREF0994_00522"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.571"/>
    <dbReference type="eggNOG" id="COG1987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164516_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN45526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="9585" checksum="D45D4BDD2DBCD71D" modified="2011-09-21" version="1">MTTEQVMEVMKEAMLVAFEMAGPLLILSIIVGLIVAVFQAATQIHEQTLTFVPKLIVIAVVLLATGSWMLNTFDGFVQRLFEIMASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K421</accession>
    <name>F7K421_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250561.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00612"/>
    <dbReference type="EnsemblBacteria" id="EGN44800">
        <property type="protein sequence ID" value="EGN44800"/>
        <property type="gene ID" value="HMPREF0994_00612"/>
    </dbReference>
    <dbReference type="GeneID" id="29726039"/>
    <dbReference type="eggNOG" id="COG1582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173020_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="86" mass="9866" checksum="A8604161C6CB4AA1" modified="2011-09-21" version="1">MIELTKINGELIVVNSRLIEYIVAIPETKIIMNNGRYHLVMEPPQEIIRKVIAFEQKVAEGWVKMNCCMAGEYIANTPEEEEKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4I2</accession>
    <name>F7K4I2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250710.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00761"/>
    <dbReference type="EnsemblBacteria" id="EGN43470">
        <property type="protein sequence ID" value="EGN43470"/>
        <property type="gene ID" value="HMPREF0994_00761"/>
    </dbReference>
    <dbReference type="GeneID" id="29723595"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.827"/>
    <dbReference type="eggNOG" id="COG5305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042639_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="523" mass="59146" checksum="10769A293F39A6D1" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4P7</accession>
    <name>F7K4P7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HMPREF0994_00815</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250764.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00815"/>
    <dbReference type="EnsemblBacteria" id="EGN43524">
        <property type="protein sequence ID" value="EGN43524"/>
        <property type="gene ID" value="HMPREF0994_00815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.889"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="489"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGN43524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="600" mass="68428" checksum="3330C276DB74DAA3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Q9</accession>
    <name>F7K4Q9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250787.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN43390">
        <property type="protein sequence ID" value="EGN43390"/>
        <property type="gene ID" value="HMPREF0994_00838"/>
    </dbReference>
    <dbReference type="GeneID" id="29724003"/>
    <dbReference type="HOGENOM" id="CLU_979304_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="31149" checksum="8450FAD18C20944B" modified="2011-09-21" version="1">MAFMGVLIAAGLFYVVFLIWLGVLVLGVVLLVLGILFEVFYGRNKRRLGVDGVGKKKWQKVAGIVCLVISVINLGLAGGSFYFITHMGPETKTVSTENGVVSVLQEERFAFEGAVERDDLDEVKRVLGENPAYWDYKAVDGSTVIGIAIANGSVEVTRFLLENGVDADVVGSSTDTAFWRCVRKIKEGIYNPEMLELLLDYGASAYREEVSYLNPIIAAMCEDGDLTDEELDLLERLVDAGMSLTNTNGIGENAEAYLERIGKEKGIADDQPDQYERGLELLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4X2</accession>
    <name>F7K4X2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250850.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00901"/>
    <dbReference type="EnsemblBacteria" id="EGN43210">
        <property type="protein sequence ID" value="EGN43210"/>
        <property type="gene ID" value="HMPREF0994_00901"/>
    </dbReference>
    <dbReference type="GeneID" id="29723917"/>
    <dbReference type="eggNOG" id="ENOG502Z7WG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017816_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="831" mass="94769" checksum="543C8B4325856897" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K567</accession>
    <name>F7K567_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250954.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01005"/>
    <dbReference type="EnsemblBacteria" id="EGN43314">
        <property type="protein sequence ID" value="EGN43314"/>
        <property type="gene ID" value="HMPREF0994_01005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1096"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="4"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN43314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="27292" checksum="4BB506418D9FA92D" modified="2011-09-21" version="1">MKTFRTLYKIELKLSLRGMDMVIFAVCLPVVMVFILGMLYGEKPAFPGSSYTFLEQSFGALTTIAVCAGGVMGLPLLVSDYRQKKVLKRFQVTPVSPVMLLAVHVAIYSTYSLVSLVLVYVCSVLFFGCRMQGSAAFFFLSYLLVMLSMFSIGMMVGGLAPDTKTASIAACVLYFPMLLLSGATLPYEVMPAVLQRIADFLPLTQGIKLLKASSLGLPMENVLLPVLVLVILLVCCSLIAVRFFKWEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K569</accession>
    <name>F7K569_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_01007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250956.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01007"/>
    <dbReference type="EnsemblBacteria" id="EGN43316">
        <property type="protein sequence ID" value="EGN43316"/>
        <property type="gene ID" value="HMPREF0994_01007"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1098"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="15"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="398"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="11">
        <location>
            <begin position="618"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN43316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="679" mass="77713" checksum="9BE970EFC6265B73" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K588</accession>
    <name>F7K588_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">HMPREF0994_00957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250906.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00957"/>
    <dbReference type="EnsemblBacteria" id="EGN43266">
        <property type="protein sequence ID" value="EGN43266"/>
        <property type="gene ID" value="HMPREF0994_00957"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1045"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_9"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN43266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="406" mass="45527" checksum="C3FEA04A3362979B" modified="2011-09-21" version="1">MKEKVILAYSGGLDTTAIIPWLKENFDYEVICVCIDCGQAEELDGLEERAKFCGASKLYVLDVIDEFCDEYVMPCVKAHAVYENKYLLGTSMARPLIAKKLVEIARKEGAAAICHGATGKGNDQIRFELGIKALAPDLKIIAAWRNDKWTMDSRESEIEYCKAHGIDLPFSADSSYSRDRNLWHISHEGLELEDPANEPNFEHLLVLGTTPEKAPDEPEYVTMTFEKGIPVSVNGEKMKVSDIIRKLNELGGKHGIGIVDIVENRVVGMKSRGVYETPGGTILYEAHQQLEELILDRETSTMKLDMGNKFAQIVYEGKWFTPLREAVQAFVDSTQEYVTGEVKFKLYKGNIIKAGTTSPYSLYNESIASFTTGDLYDHHDAEGFINLFGLSSKVRAMKHQEIEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5D4</accession>
    <name>F7K5D4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0178 protein HMPREF0994_01063</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0178 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251012.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01063"/>
    <dbReference type="EnsemblBacteria" id="EGN43036">
        <property type="protein sequence ID" value="EGN43036"/>
        <property type="gene ID" value="HMPREF0994_01063"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1165"/>
    <dbReference type="eggNOG" id="COG1671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106619_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN43036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="150" mass="16726" checksum="8DBF3DE8F3043BC4" modified="2011-09-21" version="1">MQILVDADACPVVGIVEKLARERKIPVILLCDTNHVLNSEYSEVRVIGAGADAVDFALVSLCRKGDIVVTQDYGVAAMALGKGAYGIHQSGKWYTRENIDLMLMERHLAKKARRASSKYRGKGPHKRQAADDIRFEEELRRLLDFAQKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5U0</accession>
    <name>F7K5U0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251168.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01219"/>
    <dbReference type="EnsemblBacteria" id="EGN42545">
        <property type="protein sequence ID" value="EGN42545"/>
        <property type="gene ID" value="HMPREF0994_01219"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1332"/>
    <dbReference type="eggNOG" id="COG1390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114404_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="190" mass="21798" checksum="1F67D4BDECE08085" modified="2011-09-21" version="1">MTTEEKLKHFLDVTTESTNAKNAKVLEDYTNALEKAFEEHKEESTRKAALQLKLSEDSFKKKQNAEIARAQLQIRERVSGLSEELKAKLFTEVRDKLERYMDTREYQDYLVAEIRKAKEFAGEDEVLIYIDPADSGKLNSLAAMTNTTVEVSKYGFGGGIRALIRSRNILIDQSFETKLKEAEETFVFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K640</accession>
    <name>F7K640_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251268.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01319"/>
    <dbReference type="EnsemblBacteria" id="EGN42181">
        <property type="protein sequence ID" value="EGN42181"/>
        <property type="gene ID" value="HMPREF0994_01319"/>
    </dbReference>
    <dbReference type="GeneID" id="29725097"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1441"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794074_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356666" description="SGNH_hydro domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="4">
        <location>
            <begin position="105"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN42181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="349" mass="38543" checksum="19D452FB212808DC" modified="2011-09-21" version="1">MKKVRKSIGFLMIVLMFALYFLSGCGFVQSPEDSTVESSALDYEEKIRQLQEENEKLKEELAKYVPSTEIAGESEESVTEQASASDDTVSENAVAEEAERKQIVVFGDSIWDSSRDETGIAGLLSEYMNADVYNCAIGGTRASLKDGESPDDYENWDSTSLSGMVNVATGKVNPEIFLEGYPAGGVIRNIDFSKTDYFIIAYGLNDYFSGATLNVEDGREWDAHGYGGALRYAIDELRGNFKDAQILLISPTYCQFWRDGVMYTDSNMKDFGGGPLTIYANVCRNVAENENTLYIDAYSKMGINIYNAEEYLEDGIHLTAAGRELYAKAVSSCLKYGTPGKVSGNSVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K670</accession>
    <name>F7K670_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251303.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01354"/>
    <dbReference type="EnsemblBacteria" id="EGN42216">
        <property type="protein sequence ID" value="EGN42216"/>
        <property type="gene ID" value="HMPREF0994_01354"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1475"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063441_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="179"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="372" mass="43597" checksum="5CF323BF8DAC3593" modified="2011-09-21" version="1">MKKSIVKNGYYIHSEGRSSIGVARKIDYQIELLSRHFHVRELEIKVANRKIGERIIGLMPLHSIPRNYDEVLEQMQSPDFVYIRKILADKLYINFLRSLKRKYPECKIVVEIFTYPYDKDEFLKWNTWPFYFKDRFWRMQLKDVIDRFVTYSDNDIIFNVPTIKTMNGVAVENITKVCRKNNKKTDVINLIAVANLQRSHGYERIIKGLYEYYKKGGTRKLFFYVVGEGSELKKLKRLSSKLKLDKYIIFCGRKVGEDLDIIYNQADIALAAFGLYKVGVQSISTLKVSEYLAKGMPIVTGCKERALENFQFSLELPNNNNKAEINKIVEFYDWLSELPQGMAGITEEIRNYALQKVDMCHVMEPIEEYIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6D9</accession>
    <name>F7K6D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_01444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251393.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01444"/>
    <dbReference type="EnsemblBacteria" id="EGN41918">
        <property type="protein sequence ID" value="EGN41918"/>
        <property type="gene ID" value="HMPREF0994_01444"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1573"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="365"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="399"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN41918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="583" mass="65333" checksum="483184C7B9A5BC25" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6I9</accession>
    <name>F7K6I9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="18" type="ORF">HMPREF0994_01497</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251446.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01497"/>
    <dbReference type="EnsemblBacteria" id="EGN41971">
        <property type="protein sequence ID" value="EGN41971"/>
        <property type="gene ID" value="HMPREF0994_01497"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1633"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="428"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGN41971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="661" mass="75338" checksum="B7A98DDB2B6FE979" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6V1</accession>
    <name>F7K6V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01618"/>
    <dbReference type="EnsemblBacteria" id="EGN42092">
        <property type="protein sequence ID" value="EGN42092"/>
        <property type="gene ID" value="HMPREF0994_01618"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1766"/>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009097_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="803" mass="90937" checksum="D4E418C860643F51" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7F3</accession>
    <name>F7K7F3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01782"/>
    <dbReference type="EnsemblBacteria" id="EGN41595">
        <property type="protein sequence ID" value="EGN41595"/>
        <property type="gene ID" value="HMPREF0994_01782"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_215869_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="49" mass="5727" checksum="EC5C3E05FC159E02" modified="2011-09-21" version="1">MIGSGWGWIQWAGIIAGIAVILAVKVLFMRWWGKRRKPDDKKKKWGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7M0</accession>
    <name>F7K7M0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-galactosyl-beta-1-3-N-acetyl-D-hexosamine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251827.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01914"/>
    <dbReference type="EnsemblBacteria" id="EGN41319">
        <property type="protein sequence ID" value="EGN41319"/>
        <property type="gene ID" value="HMPREF0994_01914"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2098"/>
    <dbReference type="eggNOG" id="COG5426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022367_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035080">
        <property type="entry name" value="Lact_bio_phlase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012711">
        <property type="entry name" value="Lacto-N-biose_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035356">
        <property type="entry name" value="LBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035363">
        <property type="entry name" value="LBP_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09508">
        <property type="entry name" value="Lact_bio_phlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17386">
        <property type="entry name" value="LBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17385">
        <property type="entry name" value="LBP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02336">
        <property type="entry name" value="TIGR02336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lact_bio_phlase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_M" evidence="2">
        <location>
            <begin position="440"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_C" evidence="3">
        <location>
            <begin position="664"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="718" mass="83236" checksum="CFC4683ED112DE15" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7M3</accession>
    <name>F7K7M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01917"/>
    <dbReference type="EnsemblBacteria" id="EGN41322">
        <property type="protein sequence ID" value="EGN41322"/>
        <property type="gene ID" value="HMPREF0994_01917"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2101"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363566" evidence="2">
        <location>
            <begin position="29"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="449" mass="48001" checksum="21A03E6D1A56D0C9" modified="2011-09-21" version="1">MKKKIVSVLLTAVMAASLLAGCGNSSKPAESTPAETPAPAATEEAKEETPADTTAETTADAGAADYSDVTLTFWSMWNSTEPQGKVIQEAADAFKEQTGATVNIEWKGRDINTIIATALESGEKIDIFEDDYSRIAKTYVDYCYDLTEMAKAANYDAQSFKCFNDVATEWAGFLCCVTEQPQVGGVFYNKDIFDDCGITSVPTTWDEFLTACQTMVDKGYQPLALDSAYADFTFGYHLDRVIGQDAITDLALNGGWGENKGVAEAAQQIIDFVKAGYLADGAPDEYPSSQNKIGLTGKVAMVVCANYVAAEVNNNSGTEVNWGMFNYPAVEGGADPSNAYAGANSLAISSYSENPQAAFDFLMLLTSGEFDQKMADAASQIPADPRNTAPAIMNGTIEALQATGSPLTWNMGLNENADLKANFKDIIIGLFEGKYATGEDFAAAMDALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7S6</accession>
    <name>F7K7S6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription-repair-coupling factor</fullName>
            <shortName evidence="9">TRCF</shortName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mfd</name>
        <name evidence="13" type="ORF">HMPREF0994_01971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251884.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01971"/>
    <dbReference type="EnsemblBacteria" id="EGN41376">
        <property type="protein sequence ID" value="EGN41376"/>
        <property type="gene ID" value="HMPREF0994_01971"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2166"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="642"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="812"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="230"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1177" mass="134664" checksum="42562A1D5F067E4A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7X2</accession>
    <name>F7K7X2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251931.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02018"/>
    <dbReference type="EnsemblBacteria" id="EGN41423">
        <property type="protein sequence ID" value="EGN41423"/>
        <property type="gene ID" value="HMPREF0994_02018"/>
    </dbReference>
    <dbReference type="GeneID" id="29727854"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2215"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606686_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356463" evidence="2">
        <location>
            <begin position="29"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="479" mass="52507" checksum="290FAA2A76575F2C" modified="2011-09-21" version="1">MKKNRKKLLALMLAGVMLTACGNKAEVAETKDTTAASGEESQAASDAAEQETAADTQQTDLEGAEVTFWYMPLYEGFDEKMSRDLAQEVKDKYGIILNTEVLTWDAGPEKVTVAMATGATPDLYLDTYSRIAPAIGGGLAADLSVTAEELSPLLYDGVLDTGKLNGIQGYIPINLSQGYNITVNVSMAKELGVYDLLPEDKIHWSYEEFLEFCRAAREKGKEQNIYATQLFAGSKSSDSVYYSFLMSGGSGILNEEHTEMAVDEAKAAVTLDLFRTLIEEDLVPAGAATTVDNDIRPNWYSQKLACMFVSTGTGEAVNVKKQIDSGDIQPFDVDIYEIPTPDGKADPHVMSWGSTGFTVFKNNGDETKIEAARKVIQTFLENEAYSQEVCVQTGNSTVLKDLDVDYGDEVLNEQAKRAAASTAAYADSSIGVLEPWWSDFRETFYVQLQSYFTGDKDAEDMIRDWKTSGDEVIAKTLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K808</accession>
    <name>F7K808_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxuA</name>
        <name evidence="7" type="ORF">HMPREF0994_02055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251968.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02055"/>
    <dbReference type="EnsemblBacteria" id="EGN41460">
        <property type="protein sequence ID" value="EGN41460"/>
        <property type="gene ID" value="HMPREF0994_02055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2256"/>
    <dbReference type="eggNOG" id="COG1312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058621_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00695">
        <property type="entry name" value="uxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="357" mass="40656" checksum="8F5BF4B39AF346D8" modified="2011-09-21" version="1">MQMTLRWYGSRFDTVTLKQIRQIPGVTGVISTLYDSVPGEAWPLEDILSLKKEIEDAGLQLAGIESVNIHDAIKTGSPERDAYIDNYITTLENLGKADIHMVCYNFMPVFDWTRTELARVRPDGSTVLAYTQEAVDKLNPENMFDSIAGDTNGTIMPGWEPERMEKIKDLFDMYEDIDEEKLFANLKYFLERIMPVCDKYDINMAIHPDDPAWSVFGLPRIIINKENILRMMKMVDNPHNGVTFCSGSYGTNLQNDLPDMIRSLKGRIHFAHVRNLKFNSPTDFEESAHLSSDGTFDMYEIMLALYDIGFEGPIRPDHGRMIWDEVAMPGYGLYDRALGAAYLNGLWEAIVKSHSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K819</accession>
    <name>F7K819_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251979.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02066"/>
    <dbReference type="EnsemblBacteria" id="EGN41471">
        <property type="protein sequence ID" value="EGN41471"/>
        <property type="gene ID" value="HMPREF0994_02066"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2267"/>
    <dbReference type="eggNOG" id="COG4283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133748_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012550">
        <property type="entry name" value="DUF1706"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40658">
        <property type="entry name" value="PTHR40658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08020">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031551">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="184" mass="22157" checksum="872AAC6D9BF8881A" modified="2011-09-21" version="1">MSRPATKTDLIQAAEEQFDKMWKLVDSMTPEERNAEFHFGENVKMKEAHWQRDRNIRDILVHLYEWHQLLLNWEENNKKGLAMPFIPAPYNWKTYGQMNVEFWKKHQDTSYEEAREMLLDSHRKVMELIKKYSNEELFEKKHFSWTGTSNLGSYCVSATSSHYDWAMKKMKAHMKSYRDAQKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K891</accession>
    <name>F7K891_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251777.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01864"/>
    <dbReference type="EnsemblBacteria" id="EGN41269">
        <property type="protein sequence ID" value="EGN41269"/>
        <property type="gene ID" value="HMPREF0994_01864"/>
    </dbReference>
    <dbReference type="GeneID" id="29727989"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2043"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013442_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007737">
        <property type="entry name" value="Mga_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05043">
        <property type="entry name" value="Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRD" evidence="6">
        <location>
            <begin position="193"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="6">
        <location>
            <begin position="302"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="5">
        <location>
            <begin position="413"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="4">
        <location>
            <begin position="519"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="663" mass="76709" checksum="2EBA32B7FF0CF351" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8B1</accession>
    <name>F7K8B1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251797.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01884"/>
    <dbReference type="EnsemblBacteria" id="EGN41289">
        <property type="protein sequence ID" value="EGN41289"/>
        <property type="gene ID" value="HMPREF0994_01884"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="272" mass="30118" checksum="4645F43C3BFBE8EB" modified="2011-09-21" version="1">MLQFKTEKLTDRVTRIYGFCGELMYLVEGKEKAALLDTGTGIGSLKACVQKLTDKPVMVLLTHGHVDHAMGAPEFEEVYMNHKDDYIYNEHCSLEFRKAGLEGTPLEQEVTAADFIPEAPCGTFRDLKGGDAFDLGGTTIEIYDCPGHTFGSVVMLIPEERSVLLGDACNYFTFMFDDYSTTITEYEESLKRLSGELAGKFDTVYLSHGDGNGHKEIMEDVTAVCEDIKAGNTDDIPFSFMGKRALIAKAVTPQMGRRDGGRGNIVYSKERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8B4</accession>
    <name>F7K8B4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251800.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01887"/>
    <dbReference type="EnsemblBacteria" id="EGN41292">
        <property type="protein sequence ID" value="EGN41292"/>
        <property type="gene ID" value="HMPREF0994_01887"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2069"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="259"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="362" mass="41977" checksum="3F8B0962518AA406" modified="2011-09-21" version="1">MNYQEIENKLIPLRDYEKSCREIYLANPEAFRHVVWNWEDFKEQFRRTDTSGYELGEKAPVFMGNVLTEQDCFPDENMECSIIIHDRYAPPFYHNLKFIKVVYALKGRCRFFAQGKTQDRECLLEEGDFVIVPPEMNQAVFTWEEDAVTVNIILKRSTFGEAFYSLLLENDSISDFFWQMLYSKGSSQVLVVRCGRDERLRRIVLEMCGEGLPQKDKQEAGGNLMMKGYVMLLFGWALKAHQQEMENMGSISVSEAALPVIVRYIRENYTTVTLTGLAKHFGKSEGYLSRYIRRETGKTFRFLLKEFRMKQAAGMIGNSTCSIEEVAAAVGYSDISCFYRNFKESFGCTPQQYRGRKNQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8C1</accession>
    <name>F7K8C1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrD</name>
        <name evidence="11" type="ORF">HMPREF0994_01894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251807.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01894"/>
    <dbReference type="EnsemblBacteria" id="EGN41299">
        <property type="protein sequence ID" value="EGN41299"/>
        <property type="gene ID" value="HMPREF0994_01894"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2076"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="10">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="300" mass="31965" checksum="DAF86D65C0AAE015" modified="2011-09-21" version="1">MNTKVTIAGVEFKNPVMTASGTFGSGMEYGEFVDLNQLGAVVTKGVANIPWPGNPTPRVAEVYGGMLNSIGLQNPGIDVFIERDIPFLKKYDTRIIVNVCGKTIEEYLEVVERLADTDVDMLEINVSCPNVKEGGIALGQKAECLSEITAAVKEKARQPIIMKLSPNVTDITEMAKAAEAAGADAISLINTLLGTKIDIRRRSFVLANKTGGMSGPAIKPIALRMVYQCAQAVSIPIIGMGGISNAEDALEFLMAGATGVAVGAANFINPYATEEVVKGIEAFMKEEKIQDIHEIIGCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K929</accession>
    <name>F7K929_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnfE</name>
        <name evidence="8" type="ORF">HMPREF0994_02367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252268.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02367"/>
    <dbReference type="EnsemblBacteria" id="EGN40766">
        <property type="protein sequence ID" value="EGN40766"/>
        <property type="gene ID" value="HMPREF0994_02367"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2590"/>
    <dbReference type="eggNOG" id="COG4660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046659_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30586:SF0">
        <property type="entry name" value="PTHR30586:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="27561" checksum="CE19F37C3B715C42" modified="2011-09-21" version="1">MNKPTERLYNGIIKENPTFVLTLGMCPTLAVTTSAINGLGMGLSTMVVLALSNLMISMLRKIIPDKVRIPAFIVVVASFVTIVQLLLKAYVPFLDSALGIYIPLIVVNCIILGRAESYASKNPPIPSLFDGIGMGLGFSFALTCIGLVREILGAGEFFGIPILGEKAPVIFGSHILQSYVPVTIFVLAPGAFFVLAALTAIQNKVKINGEKKGRDMSKIQSGCSYDCMSCKESGCSHRFYDTAAGGAKDAQAGKSEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K990</accession>
    <name>F7K990_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252335.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02434"/>
    <dbReference type="EnsemblBacteria" id="EGN40833">
        <property type="protein sequence ID" value="EGN40833"/>
        <property type="gene ID" value="HMPREF0994_02434"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2668"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="139"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="634" mass="72742" checksum="D8DD6F6D920C9A89" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9F1</accession>
    <name>F7K9F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-deoxy-glucuronate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40907.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359758.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02508"/>
    <dbReference type="EnsemblBacteria" id="EGN40907">
        <property type="protein sequence ID" value="EGN40907"/>
        <property type="gene ID" value="HMPREF0994_02508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084771_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40907.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="29970" checksum="CEF500980CBAABF9" modified="2013-09-18" version="2">MGKVFGYPVFDENGEKILTTYDNEYSEMRMDIRVYRMKKGEERSFLRKGEETAILLLSGKIRFCWDGKETSVSRKDVFSQGPWCLHICTEAEAAVKAEEDSEILVQCTKNETEFAAVLYRPEDAPWKYSCVGKFGNVAKRRVNTIFDHDIAPWSNMVLGEVLNDRGNWSGYLPHRHPQPETYYFLFDRPEGFGASFVGDQVFKSTDGSFSAIPGGELHPQAAAPGFQMYTCWMIRHLEGNPWLQTDRCEDGKYTWLHDAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9K7</accession>
    <name>F7K9K7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252477.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02576"/>
    <dbReference type="EnsemblBacteria" id="EGN40975">
        <property type="protein sequence ID" value="EGN40975"/>
        <property type="gene ID" value="HMPREF0994_02576"/>
    </dbReference>
    <dbReference type="GeneID" id="29725432"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2822"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="32390" checksum="6A74E131F54E5479" modified="2011-09-21" version="1">MNNSILEAKNVSKKYEGKTVLQDISLSAGKGEAIGLVGVNGCGKSTLLRILSGLSNPSSGQVSCSPGIRMALIPDRYEKINMTLQKFMDHMYRMETDRENRDEMGRYFREFYLESMLDTPMKYLSKGTLQKAGVIQALLGRRELLFLDEPLSGQDTLSQMTLIQELKKRKAAGMTLIMACHETYLIEELADRIYEIKDGHLEDGISYVYGIRRKKAILLVKYGENSGQIKERLEKQFGESLYGMTDYGSLCRLEADVQIAEELFRFFGEIKWHIVRYEEAEELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA81</accession>
    <name>F7KA81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252832.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02931"/>
    <dbReference type="EnsemblBacteria" id="EGN40540">
        <property type="protein sequence ID" value="EGN40540"/>
        <property type="gene ID" value="HMPREF0994_02931"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3199"/>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="427" mass="47095" checksum="D8C1AB3F07082FF2" modified="2011-09-21" version="1">MKKPYTKETICIQSGWKPGNGEPRVLPIYQSTTYKYETSEQMGRLFDLEEEGYFYTRLQNPTNDCVAQKICELEGGVAAMLTSSGQAANYYAVFNICEAGDHIVLSSTVYGGTFNLIAVTMKKMGISCTIVDPDSDYDTLCEAFQDNTKCVLAETIANPALVVLDIEKFAKAAHAHQVPLIVDNTFATPINCNPFQWGADIVTHSTTKYMDGHAMCVGGAIVDSGNFDWSLYPDKYPGLCQPDDSYHGVVYTERFGKKAYITKATAQLMRDLGSIQSPQNAFLLNVGLETLHLRMPRHCENALKVATYLENHDKVAWVNYPGLKSSKYYELAQRIMPNGTCGVISFGLKGGRNAAEVMMDKLELAAIVTHVADARTCVLHPASHTHRQMNDEQLREAGVNPDLIRFSVGIENADDIIADLEQALAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAJ7</accession>
    <name>F7KAJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="6" type="ORF">HMPREF0994_02823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252724.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02823"/>
    <dbReference type="EnsemblBacteria" id="EGN40432">
        <property type="protein sequence ID" value="EGN40432"/>
        <property type="gene ID" value="HMPREF0994_02823"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3090"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="94" mass="10447" checksum="CFFAF3D1B97FA3B8" modified="2011-09-21" version="1">MLKMNLQFFAHKKGVGSTKNGRDSESKRLGAKRADGQFVKAGNILYRQRGTKIHPGINVGRGGDDTLFALVDGVLRFERKGRDKKQASVYPVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAN4</accession>
    <name>F7KAN4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252761.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02860"/>
    <dbReference type="EnsemblBacteria" id="EGN40469">
        <property type="protein sequence ID" value="EGN40469"/>
        <property type="gene ID" value="HMPREF0994_02860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3128"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="231" mass="26138" checksum="30D5F03798B7E823" modified="2011-09-21" version="1">MLKENLYQVQENMKEACRRSGRAESDVTLIAVSKTKPLPMLEEVYSLGIRDFGENKVQELVDKAEQLPDDIRWHMIGHLQRNKVKYIVDKVYMIHSVDSLRLAEEISKEAVKRGIIVNILIEVNVAGEESKFGVTPEDTPGLVQEISHLPGILVRGLMTIAPFVENAEDNRIFFSALKKLYVDITNKNIDNVRMDYLSMGMTGDYEVAIEEGASFVRVGTGIFGERSYQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAR4</accession>
    <name>F7KAR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252791.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02890"/>
    <dbReference type="EnsemblBacteria" id="EGN40499">
        <property type="protein sequence ID" value="EGN40499"/>
        <property type="gene ID" value="HMPREF0994_02890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3159"/>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028644_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="540" mass="59400" checksum="533E4E20F6ACABAA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAW1</accession>
    <name>F7KAW1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_02990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252891.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02990"/>
    <dbReference type="EnsemblBacteria" id="EGN40310">
        <property type="protein sequence ID" value="EGN40310"/>
        <property type="gene ID" value="HMPREF0994_02990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3267"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="79" mass="8455" checksum="236D614C16B5CF74" modified="2011-09-21" version="1">MAVLRIILTVLFIIICIALTVLVLMQEGKAAGLGAISGAAETYWGKNKGRSMEGTLVRVTKYLAVSFIVIAAILNISKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB27</accession>
    <name>F7KB27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03056"/>
    <dbReference type="EnsemblBacteria" id="EGN40233">
        <property type="protein sequence ID" value="EGN40233"/>
        <property type="gene ID" value="HMPREF0994_03056"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031QG7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197468_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="62" mass="6239" checksum="7355E59F0C04CE51" modified="2011-09-21" version="1">MTFLINNIGTILTGAVLLIIVALVLRTMIRDKKTGKGGCGGSCGGCSNACACHGSVKSGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB28</accession>
    <name>F7KB28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase IV</fullName>
            <shortName evidence="2">Pol IV</shortName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dinB</name>
        <name evidence="4" type="ORF">HMPREF0994_03057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03057"/>
    <dbReference type="EnsemblBacteria" id="EGN40234">
        <property type="protein sequence ID" value="EGN40234"/>
        <property type="gene ID" value="HMPREF0994_03057"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3340"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="26"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="453" mass="51679" checksum="D4552DC2C5B06CFB" modified="2011-09-21" version="1">MPPDSLIFPVYRTYVLTYTFLMKPIIFHVDVNNAFLSWEAVYRLKHLGGRTDLREQLCVVGGDASKRHGIVLAKSLSAKACGIHTGESLMEARQKCPDLLVVPPHYRLYSRCSRAFMDILREYTPCVEQYSIDEAFMDMSGTQSLWGDPLLTADTLRRRIYEELGFTVNIGISENKLLAKMASDFQKPNRTHTLFPEEIPRKMWPLPVTDLFFVGRASFSRLRRLGISTIGELAHMDRELLRTHFKSYGEVIWNYANGRDCAQVESVVPPNKGYGNSTTIAFDICDTVSAGLVLLSLAETIGMRLRRDQVKIQVIAVSIKYADFSSCSHQKTLPAPTNITNEIYHTALELFHESWDGCTPIRHLGIHTNHVRDNVDYRQLHLLDMELSPFYRDDIPCCEKLEQADAMADRIRSRYGIDSLKRAVFVKQNAMDHMSGGITREKLDVDYEKESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBC9</accession>
    <name>F7KBC9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">HMPREF0994_03160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253061.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03160"/>
    <dbReference type="EnsemblBacteria" id="EGN39990">
        <property type="protein sequence ID" value="EGN39990"/>
        <property type="gene ID" value="HMPREF0994_03160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3452"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="352" mass="37878" checksum="85330958D73EF5C2" modified="2011-09-21" version="1">MYREHTREVKIGDRVIGGGNPVLIQSMTNTRTEDVEATVAQILRLEEAGCDIIRSTVPNMEAAKAIREIKKRIHIPLVADIHFDYKMAIAAMENGADKIRINPGNIGGKENVAAVVSVAKERNIPIRVGVNSGSLERQLVEKYGGVTAEGIVESALDKVKMIEDLDYDNLVISIKSSDVLMCIKAHEILAQKTDYPLHVGITEAGTLWSGNIKSSIGLGIILYEGIGDTIRVSLTGDPVEEVRTAKLLLRTLGLRKGGIEVVSCPTCGRTKIDLIGLANQVEAMVADIPLDGVKVAVMGCAVNGPGEAREADIGIAGGVGEGLLIKKGEIIRKVPEEELLSVLRDELLHWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBF0</accession>
    <name>F7KBF0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253085.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03184"/>
    <dbReference type="EnsemblBacteria" id="EGN40014">
        <property type="protein sequence ID" value="EGN40014"/>
        <property type="gene ID" value="HMPREF0994_03184"/>
    </dbReference>
    <dbReference type="GeneID" id="29728512"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3478"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067512_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="38446" checksum="FA73DEE0C46349B5" modified="2011-09-21" version="1">MKADTRLMKQLNISTLRRVLSGEGKATKPQLSRLTGLSVVTVNALITEMLEQGEVQELGMVPSGGGRPSMQYGYCYGYRTMVIIYGHQLEGRNYIHTLVVDLKGQKLWERQGYMEEIGAESFDGCLDEVFAGFGNIGLIAFGLPGEAIDDVVTINDFSGLEGLDFLPRIREKYGVPVLFENDINAMAYGYYRKHCGMDVTSLVGIYFPRSFLPGAGLILDGSIYYGNSHFAGEMGDVYVPVPWEELDYYKENQVLCQLEALLTTFACIVAPSRFVLYGDFLTDGMAERLEQYVCRRLSGKFRVQVEVSSCLEEDYETGMICLAQNRMLQLMEERTEPNTPSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBF5</accession>
    <name>F7KBF5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253090.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03189"/>
    <dbReference type="EnsemblBacteria" id="EGN40019">
        <property type="protein sequence ID" value="EGN40019"/>
        <property type="gene ID" value="HMPREF0994_03189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052873_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="264" mass="30331" checksum="B92F1173CEFF32B4" modified="2011-09-21" version="1">MQEHNEIEQTWDSYSDEHFGKLDYAEIFKEIGKDPCRGFPKAVAELLAEYFPDLKGKKVCVPSCGDCVAAFSFCEMGAEVFAADISCGQIENARKRAEGKNYNIKFLHSDSMSLNELSNDFFDLVYTSNGVHVWIRDFAAMYKNFSRILKKGGIYIMFDTHPWSRPFDKEGLEAGKFVIRKPYEETGPFPDDVTYDWRIQDYVNAFAVSGFSILRMEEFHSIPEDLPNHNYLSDKNDEPDKYDWHKNPCAALPQCLGFVCRKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBG6</accession>
    <name>F7KBG6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253101.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03200"/>
    <dbReference type="EnsemblBacteria" id="EGN40030">
        <property type="protein sequence ID" value="EGN40030"/>
        <property type="gene ID" value="HMPREF0994_03200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3496"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080975_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="14"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="264" mass="30456" checksum="1D031E322A7274D3" modified="2011-09-21" version="1">MTVKANLFPGGVRRALTMSYDDGQIFDVRLAELFDKYHIRGTFHINSGNLGGDKYVKKEDFARVYRNHEVSVHTVTHPFPTQIPDAALLKEILEDKQTLEELCGYPVRGMSYPFGDYSEHVIALARNCGMEYSRTVEATGSFAIPEDFMKWHPTAHHNGDLKKLWEQFMARDFQQMLLFYIWGHSFEFDGADNWEVMEEFCKMAGGREDIWYATNIEIKDYISASRSLVYSADMKMIYNPSCMDVWVSVDEEPVCVQAGHLWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBT1</accession>
    <name>F7KBT1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03326"/>
    <dbReference type="EnsemblBacteria" id="EGN40156">
        <property type="protein sequence ID" value="EGN40156"/>
        <property type="gene ID" value="HMPREF0994_03326"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3637"/>
    <dbReference type="eggNOG" id="ENOG5032Z1F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175375_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="86" mass="9679" checksum="7F2A30CF6DDB7564" modified="2011-09-21" version="1">MLIMNPINPMKLLQIRASWEQFKARHPKFPSFLNAVSKGAVTEGTLIEMTITTADGKQYSSNLKLTSEDMQLVNDMKEMFSGQQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC40</accession>
    <name>F7KC40_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_03419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03419"/>
    <dbReference type="EnsemblBacteria" id="EGN39926">
        <property type="protein sequence ID" value="EGN39926"/>
        <property type="gene ID" value="HMPREF0994_03419"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3738"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="164"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN39926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="43432" checksum="C7D7150054F31D54" modified="2011-09-21" version="1">MKHKFSFYLKLIVSICAGLLFCLLLYYLVDTIWNGAVLDWFDKNYMHTRSTVLNETGQEGFIREPNWYQLKNLMLRVLSFTVSLWILSVYLISRMYASRKEQAALHKTGDMIRLCMTQDNDISYIFPEEYAGISAQIMQIKSQMLRHEQILKEEAARKNDLITYLAHDLKTPLTSVIGYLSLLDEAPDMPAEQKARYTHIALDKANRLEKLINEFFEITRYNLQQIVLEKEQVDLYYLLVQLTDEFYPALTAHGNTVRLAVDENCTVYGDPEKLARVFNNLLKNAIYYSYPDTPIEITAEYGTDQIIILIRNQGKTISKQQLTSIFDKFFRLDDARTTNTGGAGLGLAIAREIVTLHGGSITAESAEELTTFRVVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCF5</accession>
    <name>F7KCF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253435.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03534"/>
    <dbReference type="EnsemblBacteria" id="EGN39443">
        <property type="protein sequence ID" value="EGN39443"/>
        <property type="gene ID" value="HMPREF0994_03534"/>
    </dbReference>
    <dbReference type="GeneID" id="29728311"/>
    <dbReference type="HOGENOM" id="CLU_751823_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="368" mass="41394" checksum="41A9DC9CD867F1B9" modified="2011-09-21" version="1">MTKLDFTIPFSGFASTTFINCFTSVYMYLEGMKQEDKGVTRCSQWENGQCSSCGNCATKPHAMQERCFFLFDTICGHSSLRCAYDGVPGEMERLINADDFYDGGAADNIEFLFGFAGYDYQAVTDTAVFMERIAASIDRNKPVIAKLKGNSVPFAVITGYDGDEIICPDFRCAQKSPEPAVTPACIDSLYLIGDKIAPKYKLADGLKRIERVMDYCLREGMWDGYMKKIGTYGPDSLGADEPEGRKARMKRLAETMWHTFDSHNFAEVFRTYLPGSLNRDAYDSINDVKKLADPAFGESIHTINWRYGYTHDLAWSIIGLDECIDWNDWKSHYYGDMLQVVIGKLKENDGAVLECVRSIIKLLDSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCQ8</accession>
    <name>F7KCQ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03637"/>
    <dbReference type="EnsemblBacteria" id="EGN39009">
        <property type="protein sequence ID" value="EGN39009"/>
        <property type="gene ID" value="HMPREF0994_03637"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3969"/>
    <dbReference type="eggNOG" id="COG5611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121449_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="118" mass="13617" checksum="5166BFAECC61E18E" modified="2011-09-21" version="1">MRKLIDANVILRYLLRDHQQMSEDARRIIENGAFTLPEVIAEVVYVLKGVYKIERHEIAGVLVEFLDDVIVENQNVVKEALFLFSETSLDFVDCILIARHRVLGDEVASFDKKLNKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCY5</accession>
    <name>F7KCY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03714"/>
    <dbReference type="EnsemblBacteria" id="EGN38878">
        <property type="protein sequence ID" value="EGN38878"/>
        <property type="gene ID" value="HMPREF0994_03714"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4054"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="34871" checksum="52668E26B94BC066" modified="2011-09-21" version="1">MSSNQAKKDSIWKRILACRELYLMLLLPVIWYILFLYTPMYGIMIAFKDYRAARGIWGSEWIGLEHFKRFFSSFYFGRIVGNTLTINIMSLLFGFPFPIFLALLLGELRNGKFRKVLQNVAYIPHFLSAVIVVSIMQLILNPNTGVYNMIRQWFGLPVTNYFASVGAFKPMYIISGIWQNMGWDAILYIAALAGIDTTLYEAASIDGAGRLQKIWHISLPGISSTITIMLLLRCGQIMNIGYEKVLLMQNSLNQASSDVISTYVYRVGILEGNFDYSTAISLFNSVCNILLLLLANAIAKRVNGTSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD14</accession>
    <name>F7KD14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253644.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03743"/>
    <dbReference type="EnsemblBacteria" id="EGN38907">
        <property type="protein sequence ID" value="EGN38907"/>
        <property type="gene ID" value="HMPREF0994_03743"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4085"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363671" evidence="2">
        <location>
            <begin position="27"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="556" mass="61589" checksum="F69392F00472848C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD47</accession>
    <name>F7KD47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38747.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03776"/>
    <dbReference type="EnsemblBacteria" id="EGN38747">
        <property type="protein sequence ID" value="EGN38747"/>
        <property type="gene ID" value="HMPREF0994_03776"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032V7X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3062702_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38747.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="53" mass="5928" checksum="89E5E88E13CD2370" modified="2013-09-18" version="2">MVLYDSAGNAVYTLDEAKALETFYTLDSSGTYTLAAECKDFIGEYKIKVYKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD49</accession>
    <name>F7KD49_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253679.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03778"/>
    <dbReference type="EnsemblBacteria" id="EGN38749">
        <property type="protein sequence ID" value="EGN38749"/>
        <property type="gene ID" value="HMPREF0994_03778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166021_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="128" mass="14717" checksum="032AFD3827AFAF9B" modified="2011-09-21" version="1">MITGFYCTNVFSEHAKELIDFYREVLEIPVIKIDADDSNGVYFGFIENAPTLCIWDCKVFDAQPTGYQSFVFQTDNLELTMESLKKKGVALSEAVRYDWGTYEVRLNDLDGNEIVIMEFVQDFNGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD96</accession>
    <name>F7KD96_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253726.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03825"/>
    <dbReference type="EnsemblBacteria" id="EGN38590">
        <property type="protein sequence ID" value="EGN38590"/>
        <property type="gene ID" value="HMPREF0994_03825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4162"/>
    <dbReference type="eggNOG" id="COG3665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079904_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="192" mass="21211" checksum="A5C0336E004BDEF1" modified="2011-09-21" version="1">MSKEYIIPACSGIKIDVQQGQNITVIDIEGGQVVDFFAEVTDKPNEFLSTGVTIDCNESIKLKIGDTIYTNLYTPMLEVLSDDVGEHDLLHPCCRPEMYDYFYHNGKGHRNCFDNINNALKEQRPIITPVNLFMYTKINTNGNITVEKPISEAGDKIVLKALLNITLGIAACSVSESQCNSGKCSSVKVIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDB3</accession>
    <name>F7KDB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN38607">
        <property type="protein sequence ID" value="EGN38607"/>
        <property type="gene ID" value="HMPREF0994_03842"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2770600_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="69" mass="8173" checksum="7CE7BCED95A7EC69" modified="2011-09-21" version="1">MTEGDVTEEAYALYGGYHGVWEVKAVFDYERKMLPKTCVMMREAFLSKLFTDCHRSTKKGTYLLFMKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDI3</accession>
    <name>F7KDI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253826.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN38690">
        <property type="protein sequence ID" value="EGN38690"/>
        <property type="gene ID" value="HMPREF0994_03925"/>
    </dbReference>
    <dbReference type="GeneID" id="29729458"/>
    <dbReference type="HOGENOM" id="CLU_820821_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="338" mass="34877" checksum="573ED963FF1A9C77" modified="2011-09-21" version="1">MVTGGKRAFIYDFIAQSWLRAGNRSAEAGFVFLFVEAVDDAEGDVALVYEGVFVGVENDAFGGGQDFLFGEAFVGIEDLGKGLVVADVFSGGGEAAVEAGGSCVDVGKVFVLDYVADVAAVAFVADDSHAGEEAQDGSGGADGAFFIEFVGFVGVDAEGGGGLVLPVVVEGFGVHGAGFADHYIGKAEQVRQGRALEAGFHHSDMGDEFSGHVKAGKLDAVGVVADLFQHSGGNPGGGVAFLVSGEAAVDVNVAYSPKTFAGVDGKRVDGGNYHDFFVGVDAAFIFQFLELFYQLGADVELLDFISAYGPCNAGGFFAFSKAVSLHQHVFSVVGFHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDK5</accession>
    <name>F7KDK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253851.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03950"/>
    <dbReference type="EnsemblBacteria" id="EGN38715">
        <property type="protein sequence ID" value="EGN38715"/>
        <property type="gene ID" value="HMPREF0994_03950"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4301"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020160_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="134"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="625" mass="72196" checksum="00667AA1FB946825" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE44</accession>
    <name>F7KE44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254024.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04123"/>
    <dbReference type="EnsemblBacteria" id="EGN36916">
        <property type="protein sequence ID" value="EGN36916"/>
        <property type="gene ID" value="HMPREF0994_04123"/>
    </dbReference>
    <dbReference type="GeneID" id="29729191"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074296_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027365">
        <property type="entry name" value="GNAT_acetyltra_YdfB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31143">
        <property type="entry name" value="PTHR31143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12746">
        <property type="entry name" value="GNAT_acetyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="266" mass="31044" checksum="F10CC2CB38262B8D" modified="2011-09-21" version="1">MVELNSYTDEVRELIDKNSSIYFISVLLFHAPGRVWVDDVENIKLALIYSEYQEGFQFMGNPVATDKCREIRGFYDNVILPFMKEKNMSIFEFGADSDELINMLTQIFSDKSMEKSEQLIFSCKEYAKSFEYDVTYQFVPLDELFFSCSYENEEYIRNEIVMSNWNIQRFLEKGFGYAALDGNRIISWAIVCISYGDVDNIGINTLDKYRNKGLATALANKVLEQIFEKNHIPIWDCDKNNYASKKVAGKCGFIEIRREKICYFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE87</accession>
    <name>F7KE87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254067.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04166"/>
    <dbReference type="EnsemblBacteria" id="EGN36959">
        <property type="protein sequence ID" value="EGN36959"/>
        <property type="gene ID" value="HMPREF0994_04166"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4540"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="112"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN36959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="313" mass="33894" checksum="AE85CA7E6A16DF2C" modified="2011-09-21" version="1">MKLVIIEPLGVEKEKLLGLAQEKLGGKVEIVYYDTRVTDTKTLVERAKDADILAFSNLPFKKEVMENCPDLKMISVAFTGVDHVAMDYCRERGILVSNCAGYSNTAVPELVFGMVLSLYRSIVACNQAVREGKDKTGLIGLELEGKKFGIIGMGAIGTRTAQLAAAFGCQVYGYNRSPKSPDGVIMTDMETLLKECDIVSLHVPLTEQTKGLIGEEQLRLMKPGAVLINTARGPVVDSNALAAALEEGRLAGAAVDVFETEPPISPEHPLLQAPNLLATPHVAFATKEALYKRAIIVFENISGYLEGRPQNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE93</accession>
    <name>F7KE93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254073.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN36965">
        <property type="protein sequence ID" value="EGN36965"/>
        <property type="gene ID" value="HMPREF0994_04172"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4549"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="455" mass="49888" checksum="439C55A1529AADCE" modified="2011-09-21" version="1">MKTKSYEIDMCNGPLTGKLLKFAVPLMLSGILQLLFNAADIVVVGHFAGHQALAAVGSTGSLINLLVNVFIGLSIGTNVLVANYTGAHQEKAVNETVHTSILLSLLCGTFLIFFGIILAKPLLSLMGTPDDVISQATLYMQIYFVGMPATMLYNFGAAVLRATGDTQRPLYFLFAAGIINVVLNLIFVICFNMGVAGVATATVISQCVSALLVLRCLLHETGCFKLYLNKLHIHKDKLVQMIRIGLPAGMQGAIFSISNVLIQSSINSFGSVAMAGSTASSNLEGFVYTSMNAFYQACLSFTSQNLGANKKERINKILITCEILVFFVGLIMGNVAYFFGDRLLHIYSSDPEVIRFGLMRMQVICTVYFLCGMMDVLVGSLRGLNYSIIPMIVSIVGVCGLRILWIFTIFQWHRSLFILYLSYPVTWLGTAVAHLICFIIIRKKLDERKHYELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEJ5</accession>
    <name>F7KEJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">[FeFe] hydrogenase, group A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254146.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04245"/>
    <dbReference type="EnsemblBacteria" id="EGN36525">
        <property type="protein sequence ID" value="EGN36525"/>
        <property type="gene ID" value="HMPREF0994_04245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4637"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="7">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN36525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="571" mass="63283" checksum="FDACCADB0108C82A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEX3</accession>
    <name>F7KEX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator, regulatory protein PadR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254310.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04409"/>
    <dbReference type="EnsemblBacteria" id="EGN35719">
        <property type="protein sequence ID" value="EGN35719"/>
        <property type="gene ID" value="HMPREF0994_04409"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4813"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="105" mass="12272" checksum="1FFD24CFCEF65306" modified="2011-09-21" version="1">MIYPLSTPLLEFLILSVVSRDDSYGYEISQQLKTVSNTKDSTLYPILKRLQENGLVDTYDQQFQGRNRRYYKITPDGRGTCEYLDNEWKKYVDAINEIAYGGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEX7</accession>
    <name>F7KEX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254314.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04413"/>
    <dbReference type="EnsemblBacteria" id="EGN35723">
        <property type="protein sequence ID" value="EGN35723"/>
        <property type="gene ID" value="HMPREF0994_04413"/>
    </dbReference>
    <dbReference type="GeneID" id="29723528"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4817"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028262_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="647" mass="72682" checksum="9FE04EDF1E17FB50" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF35</accession>
    <name>F7KF35_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254378.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN35787">
        <property type="protein sequence ID" value="EGN35787"/>
        <property type="gene ID" value="HMPREF0994_04477"/>
    </dbReference>
    <dbReference type="GeneID" id="29724624"/>
    <dbReference type="HOGENOM" id="CLU_2553914_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="82" mass="9238" checksum="0E209332D0F372C7" modified="2011-09-21" version="1">MSTIEKRLQKFYKKPIPNDITFSDIEVLAEYFGCQIITGGNHSKKVVHKASGTVIPIPVHGKYVKEAYIKELKVLFDSVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF48</accession>
    <name>F7KF48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254391.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04490"/>
    <dbReference type="EnsemblBacteria" id="EGN35800">
        <property type="protein sequence ID" value="EGN35800"/>
        <property type="gene ID" value="HMPREF0994_04490"/>
    </dbReference>
    <dbReference type="GeneID" id="29726773"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4902"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN35800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="265" mass="29415" checksum="27573F6C623CC7C2" modified="2011-09-21" version="1">MGGSTEQGMFAEERKSRIIEFINKNEKATVTQLCDKFDVSRATIRNDLNELDEKGLIKRTHGGAISTQSVNYEMNFVDREILFQGEKEAVARQALQYIREGDCIGLDAGTTTYELAKLLTEFSRLTIVTYDLNIAAFLDSNTEHAVFLAGGEIRKHFHYLTGEAALRTLQDLYLDVLFLAGNGVDAVKGLTTPNLDTARIKKCLIANSRHKVLLADHSKINNVSFTKYADVSEIDVFITDTGADKKSLKAIEEKDVEVVTVEAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFC1</accession>
    <name>F7KFC1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254451.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04550"/>
    <dbReference type="EnsemblBacteria" id="EGN35319">
        <property type="protein sequence ID" value="EGN35319"/>
        <property type="gene ID" value="HMPREF0994_04550"/>
    </dbReference>
    <dbReference type="GeneID" id="29726864"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="263" mass="29563" checksum="8AD0B3B9325AAB96" modified="2011-09-21" version="1">MKKGIIIGILQKYLGDKEKLDEVLGRVKEMGYEAIQYIIPDYVTPEEYKALLDKHGLKYLCVGAKFQAMSENPQAIQDAIKLSDLFETDYIDIDTLPVENRKSVEGYKEYAKKLNAVGAEVKKAGKKLLYHPHALEFASFGDGLIGLDVLIRETDPDVVNFILDTHWMSCGGVVLADWIRKVEGRMKIIHFKDYAIEPGIESCEQVNKRFAEVGQGNIDWPSVVAACKETGVEYAVVEQDSCYDLEPYGCAQRSYDGMVKYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFD1</accession>
    <name>F7KFD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254461.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04560"/>
    <dbReference type="EnsemblBacteria" id="EGN35329">
        <property type="protein sequence ID" value="EGN35329"/>
        <property type="gene ID" value="HMPREF0994_04560"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079356_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="221" mass="24071" checksum="4808768672491BCE" modified="2011-09-21" version="1">MGKSIAFVETSGVSSDELKALCREIIPDVKVYQLIDDSLIQEVNANCGPTPFVRRRMMEYYRNAQELGVDLIINQCSSVGEAADAIMPFLDTPVLKIDQAMAERAVELGRKIAVIATVESTTGPSVRLIESVAAKMGKEIEVDLHLVEGAMMVLIEQGDAEKHNRMVLGEVQKAAKDNDVVVLAQGSMTVLLPLLKDIPVPVLSSPRLCVERVKELLEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFP0</accession>
    <name>F7KFP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254570.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04669"/>
    <dbReference type="EnsemblBacteria" id="EGN34880">
        <property type="protein sequence ID" value="EGN34880"/>
        <property type="gene ID" value="HMPREF0994_04669"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5100"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="342" mass="38053" checksum="93C217096FA04B83" modified="2011-09-21" version="1">MSETKNILEVKDLRVSYHTYAGEVQSVRGVSFELETGKALAIVGESGCGKSVTAKSIMGLIKGPAGEIKEGSTILYNGDNILNYSKKQWQAYKGGECAIIFQDALASLNPTMRVGKQIMENLMAHKNMDKKSAQKEAVEMLRMVGIPEPEKRVKQYPHEFSGGMRQRVMIAIAFACDPKLLICDEPTTALDVTIQGQILDIIKDLQKKHNTSVIIITHDLGVVANLAQDIAVMYSGVIVEKGKCADIFYRPRHPYTWALIESVPRLDLENKQELASIPGTPPDLLNPPKGCPFSTRCRYCMEICKEEMPERTDFGDGHMASCWLHHEMAPKVEMPERKGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFT6</accession>
    <name>F7KFT6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254616.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04715"/>
    <dbReference type="EnsemblBacteria" id="EGN34641">
        <property type="protein sequence ID" value="EGN34641"/>
        <property type="gene ID" value="HMPREF0994_04715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5147"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="108" mass="12158" checksum="11B59F8D37D3A1F7" modified="2011-09-21" version="1">MSVTAIGKVNFDKEVLQSELPVLVDFWAPWCGYCRRLSPVIDQLDAAYEGRLSIRKVNIDEEPELADTYEVETIPTLYLFQKGKAPVSVIAPQAKSQVTDWLKENGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG31</accession>
    <name>F7KG31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254711.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04810"/>
    <dbReference type="EnsemblBacteria" id="EGN34437">
        <property type="protein sequence ID" value="EGN34437"/>
        <property type="gene ID" value="HMPREF0994_04810"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103067_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="181" mass="20897" checksum="F874674162A67981" modified="2011-09-21" version="1">MQINVIHIYGGSGSGTSTLGDAFSRESGYYFMDADDYLWLPTNPRFTQMRESGERVRLMKEDIKEHKKVVISGSVTGWGDPLIPMFDLAVRLVTDVDIRIARIKTREAERFGDRILPGGDMYKQHQDFLEWAAAYDTGDVNMRSRALHDQWQKQLDCRQLVLDGGRPVEENLERIRMELNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGC1</accession>
    <name>F7KGC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_04900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254801.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04900"/>
    <dbReference type="EnsemblBacteria" id="EGN34190">
        <property type="protein sequence ID" value="EGN34190"/>
        <property type="gene ID" value="HMPREF0994_04900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5350"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="326"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="560" mass="63453" checksum="56A45FF5A23D1B6F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGD1</accession>
    <name>F7KGD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254811.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04910"/>
    <dbReference type="EnsemblBacteria" id="EGN34200">
        <property type="protein sequence ID" value="EGN34200"/>
        <property type="gene ID" value="HMPREF0994_04910"/>
    </dbReference>
    <dbReference type="GeneID" id="29727791"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5363"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="628" mass="71192" checksum="F71807300FAF3C5F" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGL5</accession>
    <name>F7KGL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254895.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04994"/>
    <dbReference type="EnsemblBacteria" id="EGN33789">
        <property type="protein sequence ID" value="EGN33789"/>
        <property type="gene ID" value="HMPREF0994_04994"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5455"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="33034" checksum="0FDD052338CFCC70" modified="2011-09-21" version="1">MKYKKFAAKIRPYIMTAPALAGILLFTIYPIIKLIQLSLMNTNMLNPSESRFIGLDNYRKVLSRPDFHKSLNNTVVYTIAVVLIITAIALLLAVWLSEKSSKLNRLVQAAVFCPHVVSIVSIALIWLWMMEPNFGLFNFLLRKLGLPTSSWLSGSSTAMPSVILVSVWKAVGYDTLIFMAALQSVPASLYEAAKLDHANKVVIFFKITLPMISPQLFFTLIIRTISSFKVFDTVRILTQGGPNNATTTLVYSIYTEALLNLRIGYSAAIGVILLIIVSILTVIYFWGFSRKVHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGN0</accession>
    <name>F7KGN0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254910.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05009"/>
    <dbReference type="EnsemblBacteria" id="EGN33804">
        <property type="protein sequence ID" value="EGN33804"/>
        <property type="gene ID" value="HMPREF0994_05009"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5471"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952405_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="35380" checksum="CDA3E2CDDD4B8507" modified="2011-09-21" version="1">MQWEKVELAARMQNYIRDHCMDADFTMDALYEAAGYSRRHACRIFKELMDKTPEEYVRAVQMTASAESLIKTDSTILDIALDTNFESHEGYTRAFNKLFGTTPSRYRHGQVPIPLFVQYPIQHYYSYLKQKEIQEMENQSNTPQERESSQSICTVTVIHKPARKLLVMYAQKAHDYFSFCEEMSCEWEGLFNSIPNRLETAALMTLPPSLHPEGTTETAAGVELPEDIDITVPEGCTLLSLPPCDYLYFQSPPYEKEEDYCIAIESVFQASQTYRPERFGYAYAPELAPSVNFGADTLTGGCIALPVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGY2</accession>
    <name>F7KGY2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255012.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05111"/>
    <dbReference type="EnsemblBacteria" id="EGN33144">
        <property type="protein sequence ID" value="EGN33144"/>
        <property type="gene ID" value="HMPREF0994_05111"/>
    </dbReference>
    <dbReference type="GeneID" id="29726257"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5586"/>
    <dbReference type="eggNOG" id="ENOG502ZCFE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056695_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="395" mass="43983" checksum="DB0A7A474D30A425" modified="2011-09-21" version="1">MEKTKKLSVNTALCDMTEITEERLSQYSAIAINAAAVIQSEKSAVLISKYPVEINTACVIKVPEGINLIIKNGSIEINEKAFAAEHSFLFVSGSLFIHPAAGKALESYEKIMVNGSLIYPEGLSDAVSKIQVNGTQKSYPDNAICLLKDVDVDKYFILRARQDTPYFINGMVKLLDASLDLAALIRKNVTFLCKKAMVMECLFEQSLSLFDEHTEIQIIPDECRILPDNTELDSGTVSLFGKKLYKNGDLTLTDQSMEALPELEYLKVTGTLYIPEKYSRNLSEFPVEYGSIFVIKGTMISDRSNIRIDKQLLEQTPGGLHVVDCAVAEISEDVPPELIRSRLRLEDIAVVRCSPEIRNAVELVSADVALFEDYKDEEVQEDDDTSFVNAASYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH22</accession>
    <name>F7KH22_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_05158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255059.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05158"/>
    <dbReference type="EnsemblBacteria" id="EGN33191">
        <property type="protein sequence ID" value="EGN33191"/>
        <property type="gene ID" value="HMPREF0994_05158"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5638"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="143"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="425" mass="48357" checksum="C60325FA306842AD" modified="2011-09-21" version="1">MIDIKFLRENPEAVKENIKKKFQDSKLSLVDEVIELDKESRQTQQEADDLRASRNKISKEIGGLMKDGKKEEAEAKKAEVAAGAKRLAELEEKETELQEKITKIMMLIPNIIDPSVPIGKDDTENVEITKYGEPVVPDFEIPYHTEIMERFNGIDLDSARKVAGNGFYYLMGDIARLHSAVISYARDFMINRGFTYCVPPFMIRSNVVTGVMSFAEMDAMMYKIEGEDLYLIGTSEHSMIGKFIDTIVPEEELPKTLTSYSPCFRKEKGAHGLEERGVYRIHQFEKQEMIVVCKPEESPMWFDKLWQNTVDLFRSMDIPVRTIECCSGDLADLKVKSYDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVNGENGKYFAHTLNNTVVAPPRMLIAFLENNLQADGSVKIPAVLQPYMGGMTEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH28</accession>
    <name>F7KH28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid replication initiation factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05164"/>
    <dbReference type="EnsemblBacteria" id="EGN33197">
        <property type="protein sequence ID" value="EGN33197"/>
        <property type="gene ID" value="HMPREF0994_05164"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5644"/>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037938_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003491">
        <property type="entry name" value="Rep_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040819">
        <property type="entry name" value="Rol_Rep_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02486">
        <property type="entry name" value="Rep_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18106">
        <property type="entry name" value="Rol_Rep_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="70"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="453" mass="53438" checksum="37CD13E772691C62" modified="2011-09-21" version="1">MCRKARQHKPLVSNRGVQIDRQQPNNRAESHGTQGIFPYPACVNKALKVDIRFFRQEGFSLNEETWVRDIKEKREVYGISQQKLALAAGITRPYLSDIETGKAHPSEALQEAITEALERFNPDNPLEMLFDYVRIRFPTTDVKHIVEDVLRLKLSYFIHEDYGFYSYTEHYYLGDIFVLVSPELEKGVLLELKGRGCRQFESYLLAQERSWYEFFMDVLMEDGVMKRLDLAINDKTGILNIPHLTEKCRNEECISVFRSFKSYRSGELVRREEKECMGNTLYIGSLQSEVYFCIYEKDYEQYKKHDIPIADAEVKNRFEIRLKNERAFYAIRDLLEHDNPERTAFQIINRYVRFVDRDDTKPRSDWRISEEWAWFIGEHRGSLKLTTKPEPYSFERTLHWLSHQVAPTLKLALRLDKMNHTQIVHDIITHAKLTEKHEKILKQQAAAAKEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHA7</accession>
    <name>F7KHA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255104.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05246"/>
    <dbReference type="EnsemblBacteria" id="EGN33279">
        <property type="protein sequence ID" value="EGN33279"/>
        <property type="gene ID" value="HMPREF0994_05246"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5729"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000181_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="2070"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="2500"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2894"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2829"/>
            <end position="2856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2910"/>
            <end position="2927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="2927" mass="331527" checksum="5AF5D21FE980B492" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI45</accession>
    <name>F7KI45_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255319.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05476"/>
    <dbReference type="EnsemblBacteria" id="EGN32917">
        <property type="protein sequence ID" value="EGN32917"/>
        <property type="gene ID" value="HMPREF0994_05476"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5987"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="278" mass="31532" checksum="C0F560D381D1C480" modified="2011-09-21" version="1">MRINMKKTGKNLLVLLALLPGIILIIFPMYVTIVTAFKTPQESGSSFFALPSSFFLGNFISVLNKSYYFRYILNTAVILVCSVIVELLIVPMAAYSIQRNNRKYYRFLYIFIVCGLFVPFQVRMVSLVQMMSQLHLMSKLGMVFLYLAATTPPGVFLITGYLKSVPEQIEEAAYMDGSSYGATYFRVVFPLLKPILSTLLIKDSLFIWNDFQLPLIILNGSTKSWTLQLFQYNFKSQYSFDYNLAFASFIMTMLPILILYILIQKNIVAGLSAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIT6</accession>
    <name>F7KIT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000013">
        <property type="protein sequence ID" value="EGN31906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569232.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05765"/>
    <dbReference type="EnsemblBacteria" id="EGN31906">
        <property type="protein sequence ID" value="EGN31906"/>
        <property type="gene ID" value="HMPREF0994_05765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6303"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="3">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="4">
        <location>
            <begin position="166"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="536" mass="61929" checksum="DCBB9D12948E5759" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIW0</accession>
    <name>F7KIW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05789"/>
    <dbReference type="EnsemblBacteria" id="EGN31865">
        <property type="protein sequence ID" value="EGN31865"/>
        <property type="gene ID" value="HMPREF0994_05789"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030JS4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497584_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="616" mass="69956" checksum="8EA27DF92F2D889A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ18</accession>
    <name>F7KJ18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05847"/>
    <dbReference type="EnsemblBacteria" id="EGN31475">
        <property type="protein sequence ID" value="EGN31475"/>
        <property type="gene ID" value="HMPREF0994_05847"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6398"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_7_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="203" mass="23383" checksum="05D7B29D6CBC6A35" modified="2011-09-21" version="1">MAGAGGGKLRDADGGSRHRPGTSTRRAQRLSQNLKRSLRRNCRNAVIRKMDRKQLAHDSIMRFRKTDTMLRRYLDRKVSNTGVFPTQHRLLMELDRNPSCSQVDLAEKFDVSAAAIAVSLKKLEKGGYITRLADENDNRINQVSITAKGKEVIHKSILIFQETDRCFFEGFTDEEVEQFFHFMEKAYKNMAEQNSRLDAEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ94</accession>
    <name>F7KJ94_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">HMPREF0994_05931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255707.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05931"/>
    <dbReference type="EnsemblBacteria" id="EGN31559">
        <property type="protein sequence ID" value="EGN31559"/>
        <property type="gene ID" value="HMPREF0994_05931"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6490"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_9"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="184"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="464" mass="53300" checksum="9595EE5D0C3FD036" modified="2011-09-21" version="1">MSEKNTFTIFGGTGDLTFRKLLPALYNMEMTGSNPFDTQIVIVGRRDYTSTAYRELARDWVEKFARLHFREDVYQRMAERIVYYRMDFTKEEAYGELNDFYHEINAGNHIFYFAVAPRFFPVIVQGLKKVEGAQGGKVVLEKPFGESLEAAAALNEKMEAFFSPDHIYRIDHYLGKEMVRNIQTIRFANPIFSNVWDAEHIECIQISALEEVGVETRGGYYDHSGALKDMMQNHLFQILSIVAMEQPRSPAVEDMHREQMKVLAALVMPEDISGSMVLGQYEGYRGEPSVAADSHTETYAAVRLLVDNERWKGMPFYIRTGKKLEKREMQVAIVFKSPSPEAESNILNIRIQPTEGVYLQFNIKRPGETEEIIQAKMDFCQSCSVEHHLNTPEAYERLIGACFKGELSWFSQWDQVGLSWKYVDALKDAYRRNGQPVFSYEQGCSGPKEAEQLLAGYGHSWFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJB9</accession>
    <name>F7KJB9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255737.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05961"/>
    <dbReference type="EnsemblBacteria" id="EGN31589">
        <property type="protein sequence ID" value="EGN31589"/>
        <property type="gene ID" value="HMPREF0994_05961"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6524"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="188" mass="21406" checksum="0EAA1475CF52B038" modified="2011-09-21" version="1">MKVVIVWSSPNENGLTASAKESFLSGLKKAGTEYEEVHLNKFKTEHCLACGNGWGTCRSEGRCIIKDDFESIYRKLMEADGIVFISAVYWHDVTEHMKAFIDRLRRCETGHNGFLAQKRCILIACAGGTGLGAIECLYNMEEALKHMGMRAYDRIPVIRYNRDYMLPALEQAGEVYVERLKDGFDMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJY3</accession>
    <name>F7KJY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_06172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06172"/>
    <dbReference type="EnsemblBacteria" id="EGN30665">
        <property type="protein sequence ID" value="EGN30665"/>
        <property type="gene ID" value="HMPREF0994_06172"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6760"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="155"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN30665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="379" mass="42839" checksum="4FFA6532956781F0" modified="2011-09-21" version="1">MKKKMERFFGTHQLRYACRLAGIMLITSLFSFLLHWLGIGKENILMLFIVGVLLVAYCTNGYPYGVTASVVSVMVFNYLFTEPVRTFSISNQDDVILLLFFLVAALISSNLTVRFRKQVEVARKNEQLAEQLTMEQERIKFAMEKEQMRSNLLRSISHDLRTPLTGIAGASSLIAESGDKMDPESIMSLGKDINEQADWLIQLVENILNMTKIDSGKLVVEKKPEAVEDVITNALAYVKGRRKQRRVEIDIPEEMLLVKMDGRMIVQVLINLLDNAIKHTKEDGVILIKAQKDEKGVWFYVEDDGTGIEEKIKERIFDEFVTFRPVSRDTGKGIGLGLAICKAIVTAHGGMIDASNREEGGASFRFFLPFEDRNGKDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK46</accession>
    <name>F7KK46_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06149"/>
    <dbReference type="EnsemblBacteria" id="EGN30642">
        <property type="protein sequence ID" value="EGN30642"/>
        <property type="gene ID" value="HMPREF0994_06149"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6735"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024860_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363850" evidence="2">
        <location>
            <begin position="25"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN30642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="479" mass="54680" checksum="C8ED00A02185F27E" modified="2011-09-21" version="1">MRIKAKRMILIIVVCIVVYLVAGAMGPFIKYKDVSGQTVEEFRADSFRSSEAGTDRAMLLETSESALEHRIRLINGAKSRIILSTFDMRNGESTKDLLSVIWHKAEEGVKVQILVDGVSGLIRMEPDPLFHAVASHPNIQIKIYNPVNPLMPWKTQGRMHDKYVIVDDSAYILGGRNTFDYFLGDYDSKNKSLDREVLIYNTAQGEENSGESSLFQVEAYFNRVWNLDVCRLFHDDEGQQKKKRIQKQMELLEARYQELREKQEGFFDTAYDYTAHTCAANRIRLVSGPTGIYGKEPDIFYTLTELMKQAQERVVIHTPYVVTNDYMNETLTEIVDTVPQVKMVINSVENGDNFVASSDYQYHKKDVIATGISLYEYDGGLSTHGKSLVIDNDLCAVGSYNFDLRSTYMDTELMLVIQSEELTQQLMEYMGDIEKDCRLVVDEKNYVVPDHVTVAKVPFLKRLAWKVVGLLLQPFRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKJ1</accession>
    <name>F7KKJ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">HMPREF0994_06370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256132.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06370"/>
    <dbReference type="EnsemblBacteria" id="EGN47978">
        <property type="protein sequence ID" value="EGN47978"/>
        <property type="gene ID" value="HMPREF0994_06370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6972"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN47978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="69" mass="7975" checksum="F976F346FEB78694" modified="2011-09-21" version="1">MKTKQYVEDLKKKSDADLAQELVNAKKELFNLRFQNATNQLDNTARIKEVRKNIARIQTLITEKAKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKJ9</accession>
    <name>F7KKJ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplD</name>
        <name evidence="8" type="ORF">HMPREF0994_06378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256140.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06378"/>
    <dbReference type="EnsemblBacteria" id="EGN47986">
        <property type="protein sequence ID" value="EGN47986"/>
        <property type="gene ID" value="HMPREF0994_06378"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6980"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="206" mass="22735" checksum="6EBA15D10AE28023" modified="2011-09-21" version="1">MANVAVFNMEGKEVGTLDLSDAVFGVEVNEHLVHMAVVWQLANKRQGTQKAKTRSEVSGGGRKPWRQKGTGHARQGSTRSPQWTGGGVVFAPVPRDYSFKLNKKEKRAALKSALTSRVQENKLIVVDELKFDEIKTKNFKQVMDNLKVSKGLVVINENDKNVVMSAKNMPTVNTTLTSTLNVYDVMKAGTVVLTKDAVKTIEEVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKQ8</accession>
    <name>F7KKQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256199.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06437"/>
    <dbReference type="EnsemblBacteria" id="EGN47572">
        <property type="protein sequence ID" value="EGN47572"/>
        <property type="gene ID" value="HMPREF0994_06437"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7047"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="31031" checksum="A13B77C89CF8DFE3" modified="2011-09-21" version="1">MKEYVCVDIGGTAMKYGVVQEEGKFLETGEIPTEAWKGGPGILEKLERICEEAGRRHRLSGICISTAGMVDCEKGEITFSGPQIPDYAGTGLKKRMEERFGLPCEVENDVNCAGLAECLAGAAKGCASAVCLTIGTGIGGAILFHDRVYHGFSGSACEVGYMNIPGGMFQDLGSAGALLSRVAGEKGLAAADIDGKWVFEQAEAGDGCCIRAIDEMTDVLGTGIANICYVLNPEIVVLGGGIMSRKEYLLPRIQAGLKKHLLPAVREKTRIAFAQNGNQAGMLGAFFHFMAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL46</accession>
    <name>F7KL46_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256341.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06579"/>
    <dbReference type="EnsemblBacteria" id="EGN47298">
        <property type="protein sequence ID" value="EGN47298"/>
        <property type="gene ID" value="HMPREF0994_06579"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="32997" checksum="6985117CC28C7134" modified="2011-09-21" version="1">MKKTLKREFPYLLFILPAFLGYTTFTIVPLLNSFKYAFTNWDGFNRAEFVGFKNFLDLFGDAPMMRALMNTLVYAVSVPLLVTLFAIPLAVLLNGKMKTRNLQRAVFFFPSVPSVLILGYLWSYMLSPTGRGLINTILAIFHIDKVLWLGKPMLAMFSIIMVSVWSQIGWHACIYLANLQSIPSSYIEAARIDGASGWDIFRHITFPMLAPSMTISVMLLLTGSLKVFDLPFSLTNGGPGYSTLMVTQIIITRGVTEKLYGKATAMSVVFFFVICICTIIQLSLMKKREEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL69</accession>
    <name>F7KL69_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5720 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862445.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06602"/>
    <dbReference type="EnsemblBacteria" id="EGN47321">
        <property type="protein sequence ID" value="EGN47321"/>
        <property type="gene ID" value="HMPREF0994_06602"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031U4Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173944_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043778">
        <property type="entry name" value="DUF5720"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18987">
        <property type="entry name" value="DUF5720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5720" evidence="1">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="90" mass="10733" checksum="48D063E890856516" modified="2011-09-21" version="1">MKDIAARELKGHNILAVERFWDSTFWMIEFTVLRPTAYGEPGDEMRLFLTEDGYQSALQSQQRREIKIKRYAHVIEGHILDFKPKKHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLD0</accession>
    <name>F7KLD0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Signal peptidase I</fullName>
            <ecNumber evidence="4 7">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_06659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256412.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06659"/>
    <dbReference type="EnsemblBacteria" id="EGN46583">
        <property type="protein sequence ID" value="EGN46583"/>
        <property type="gene ID" value="HMPREF0994_06659"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_5_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="9">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="193" mass="21179" checksum="BA2F118EBEBFECE0" modified="2011-09-21" version="1">MRKSKGLSFYRRRKKISTAILHEILSYVLGIAIAAFLAFVIVYFVGIRTSVIGVSMEPALYNGQEILINRFIYKLSNPKAGDVVVFLPNGNQNTHYYVKRVVAVPGETVQIVEGILYVNGAPVEDDTYDLIADAGIAEHEIKLGNDEYFVLGDNCNSSEDSRSGNIGAVARDDIVGKAWFKLSEGSNSMGPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLK0</accession>
    <name>F7KLK0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256491.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06738"/>
    <dbReference type="EnsemblBacteria" id="EGN46662">
        <property type="protein sequence ID" value="EGN46662"/>
        <property type="gene ID" value="HMPREF0994_06738"/>
    </dbReference>
    <dbReference type="GeneID" id="29724748"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="32257" checksum="8ABFFB67A9B850D6" modified="2011-09-21" version="1">MKKINTEKLYQAFIYIVVGLLVIVSIFPLVYVVGLSLTSETEFLQRGNLMVLPREPTLAGYRRILLATDSYVKGLGISVVRVIVGTVANMLCNMTLGYIISRKDFPGNKVLMGMVLFSILYNGGTIPTFLTVSGVGILNTFWAMIIPGLVDGWSVLVFRQFFSNIPKDVLESAEIDGCSELPKFIRVVLPMSKPVIASLGLFSAVGHWNSWFDAAIYLGSKSEKFPLQLILRNLLINANLGAEASMDKVGVQAIQTPTSLRMVVVVVGTIPILCVYPFLQKYFTAGVYTGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLQ3</accession>
    <name>F7KLQ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256535.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06782"/>
    <dbReference type="EnsemblBacteria" id="EGN46374">
        <property type="protein sequence ID" value="EGN46374"/>
        <property type="gene ID" value="HMPREF0994_06782"/>
    </dbReference>
    <dbReference type="GeneID" id="29726772"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7410"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="324" mass="36983" checksum="1D61E651225E9EA2" modified="2011-09-21" version="1">MDRVSLTNTDLQVSQLCLGTADFGTKKSREEAFRQMDIFLDGGGNFIDTAHVYGDWACDERGRSEKVIGEWLKGKRDQVILSSKGCHPPIDNMLCSRVDPGNLHKDVEESLSQLQTDYVDLYFLHRDNPQVPAGELLEALEEEVRRGRLRYYGCSNWSLDRLKEADAYAREHGLHGFACNQMMFVLADVVPETLVEPQLTILDDAYYQYEKQTGLSFMAYMCLAGGYFSKRMAGKPVSPQQKERYHGEANEAILRQLKLCVSEGYKVTDFLYSYVKRAAFPSIPISGFGNEEQLKQALVSIEQEVPDEMMHDLVSLKRMQSYHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLU7</accession>
    <name>F7KLU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000006">
        <property type="protein sequence ID" value="EGN46055.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06826"/>
    <dbReference type="EnsemblBacteria" id="EGN46055">
        <property type="protein sequence ID" value="EGN46055"/>
        <property type="gene ID" value="HMPREF0994_06826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031869_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46055.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="442" mass="51387" checksum="ADEA1C1E1AE10CB8" modified="2013-09-18" version="2">MQPPQSIEEIKAGLETTEKGGVRQSIRNCLTVFQRDPLLSGAIAYNILTDRKDIIKPIGFHRESTALNDTDMKYLLLYLEETYGLTNEKKIDNAIGIVANENKYHPIRDYLNTLVWDGTERIRFCLRHFLGADADDYTYEALKLFLLGAISRAFQPGCKFEIMLCLVGGQGAGKSTFFRLLAVRDEWFSDDLRKLDDDNVYRKLQGHWIIEMSEMMATANAKSIEEIKSFLSRQKEVYKIPYETHPADRPRQCVFGGTSNALDFLPLDRSGNRRFIPVMVYPEQAEVHILEDEAASRAYIEQMWAEAMEIYRSGRFKLAFSPTMQRYLKEHQRDFMPEDTKAGMIQAYLDKYTGSMVCSKQLYKEALNHAFDEPKQWEIREINEIMNQCIDRWRYFPNPRMFSEYGRQKGWERENPATDSGNPSEKTMDGFVEVTEQMELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRG9</accession>
    <name>S2KRG9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EPC05039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360332.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07312"/>
    <dbReference type="EnsemblBacteria" id="EPC05039">
        <property type="protein sequence ID" value="EPC05039"/>
        <property type="gene ID" value="HMPREF0994_07312"/>
    </dbReference>
    <dbReference type="GeneID" id="29729689"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019175_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="647"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="757" mass="87967" checksum="43073F35CEBFFAA9" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRZ4</accession>
    <name>S2KRZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EPC05052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07301"/>
    <dbReference type="EnsemblBacteria" id="EPC05052">
        <property type="protein sequence ID" value="EPC05052"/>
        <property type="gene ID" value="HMPREF0994_07301"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044821_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="34"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="328" mass="37857" checksum="3F50B446E3FADD7A" modified="2013-09-18" version="1">MISDYLLGAAADSYGFDRASCRFITYGREKNKQMYTFVKNKKQYVLRIIKNPADSIGQTKAEMDWLMYLAQKGVTVPSPLKTERGELAFSAEENGETCFISAFRRMDGLRWDKNNPKLWNKGVFYNWGKTVGNMHRFTRDYTPGDGMEKRHEFSIRSMMSENIKTFPTVNKIAEDLLKEIETLPKDKDSYGLIHNDLHPGNFLIDGERIHLIDFDGCMYSWYAFDIGNALYLALWLGRSDEAGNDFTNDIIEYFLKGYLSVNLMSDFWLSKIPLFMMACKIALFSMGCDCEEPGNTLSEDIQKERVRSIENNVLFTGCMADYSLFRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSC6</accession>
    <name>S2KSC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_07042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359859.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07042"/>
    <dbReference type="EnsemblBacteria" id="EPC05374">
        <property type="protein sequence ID" value="EPC05374"/>
        <property type="gene ID" value="HMPREF0994_07042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EPC05374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="458" mass="52361" checksum="7629DBE835D3AB92" modified="2013-09-18" version="1">MTEKEITEEVVEEGVHNYSAADAYVWPADPKVRQKLEWFQDQKLALMMHWGPYSQLGIVESWALSDADAEWSRKGIDWEASGKEFKEQYFGLNRTFNPIRFDPERWADLAEEAGIRYLLFTTKHHDGFCMWDSRYSDYRITAEDCPFHTHKYADICGHLFEAFRKRGIGIGAYFSKADWHVDSYWKKGCARDDYMWRGPSYDPAARPEEWERFVTFTQNQIKELAARYGKLDIMWFDAGWVCPQSGQDIRLGEVIDEIRNWQPGMLCADRTVGGPYENYITPEQCVPDQPLGVPWESCITLGTSFSFAYEDTYKKPREVILLLIDIVAKGGNLAINVGPQPDGRLPAGAVESLKGMGRWLKLYGDAIYGTRVCAPYKKGNIAFTQKDGKVYALELFPEEGSPVPEEVFLPWEGEVKKVSLLDCGKEVPFTAGKGGILVKMLPFEEETAPIARVYVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSF5</accession>
    <name>S2KSF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EPC05217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07128"/>
    <dbReference type="EnsemblBacteria" id="EPC05217">
        <property type="protein sequence ID" value="EPC05217"/>
        <property type="gene ID" value="HMPREF0994_07128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="383"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="481"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="594" mass="67071" checksum="F33F2EEBEE9B9585" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAG0</accession>
    <name>S2LAG0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EPC05221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07132"/>
    <dbReference type="EnsemblBacteria" id="EPC05221">
        <property type="protein sequence ID" value="EPC05221"/>
        <property type="gene ID" value="HMPREF0994_07132"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2683134_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="74" mass="8558" checksum="22E3C60D078F0D06" modified="2013-09-18" version="1">MFFRMNREKMAGENLREGNMEVAFELWIERDRAGSDTPGRIPSRLQRRFPPLSGKAISEAGTVFPYCTKCRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>S2LK12</accession>
    <name>S2LK12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_07112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359983.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07112"/>
    <dbReference type="EnsemblBacteria" id="EPC05263">
        <property type="protein sequence ID" value="EPC05263"/>
        <property type="gene ID" value="HMPREF0994_07112"/>
    </dbReference>
    <dbReference type="GeneID" id="29723593"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="369"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EPC05263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="594" mass="66699" checksum="33409086789CAB7B" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2L1</accession>
    <name>F7K2L1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250039.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00090"/>
    <dbReference type="EnsemblBacteria" id="EGN42707">
        <property type="protein sequence ID" value="EGN42707"/>
        <property type="gene ID" value="HMPREF0994_00090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.95"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="334" mass="37014" checksum="F26CCA380E9F6B34" modified="2011-09-21" version="1">MKKMYIVTGADGHLGSTVVRMLEQEDCLVRGLILPGEEGVNRGNVVYYRGDVRRRETLLSLFENTDDMEVTVIHTAGIIDISGKVTPLVYDVNVNGTKTIAGLSLEKQVKRFVYVSSVHAIPENGDYGVMKEVTEFSEKTVTGGYAKTKAEATRAVMALVKLGLDAVVVHPSGILGPFGGTGNYLVQLVNDYIMGRLPACVKGGYDFVDVRDVAKGCLLAASKGRKGECYILSNRHYEIKEVLAMARKVCKCRSVPVLPMWMARAAAPLLAGYAKCRKKRPLYTRYSLYTLKSNDRFSHDKATKELGYSPRDLMQTIKDTVQWLREGKKQICLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2P7</accession>
    <name>F7K2P7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250075.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00126"/>
    <dbReference type="EnsemblBacteria" id="EGN42743">
        <property type="protein sequence ID" value="EGN42743"/>
        <property type="gene ID" value="HMPREF0994_00126"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.133"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031786_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="451" mass="49502" checksum="0850CC5394081D68" modified="2011-09-21" version="1">MRVKNTLDEWIALHEQEFIQDITALVEIPSVSVKGGSTPCGEECFRALEKMLELGKNYGLETEMIGGRCGRISLGEAEREIGIWNHLDIVPAGEGWTYPPFACQRQGDFLIGRGTQDNKGPAVAVLYALRYLKEQGMPAKVRFSQILGCEEECGMEDAGWYVTQRRAPDWSFVADCGFPVCCGEKGICRIALRSEKIMERIKDISGGTAVNSVPAHAAAVLEHDGELVSIEAEGISGHAAFPEGTENAVKLLAEQLMTYPLGEKEYKMAEFLGKICTDGYGIGLGIACEDSLSGRLTCNCGLIRSREGAVIFQLDIRYPVTFSGAQIIEKVRTAAEEGGFRITETEDDPPFYLEPGLPFIQILMEAYQEETKERKLPYVMGGGTYARRIPHAVAFGPGMSADMRELKLPAGHGGCHSADEAQSIANLQKAIRIYVQVIEKLNLWMTGETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2P9</accession>
    <name>F7K2P9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250077.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00128"/>
    <dbReference type="EnsemblBacteria" id="EGN42745">
        <property type="protein sequence ID" value="EGN42745"/>
        <property type="gene ID" value="HMPREF0994_00128"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.135"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="279" mass="32175" checksum="C4325161E576E7DF" modified="2011-09-21" version="1">MGKIKEALGWKILRDILLACGLVLILFPLYLVLINSFKTLDEAGKNFFALPSGINFGNFIELFTNSNYWIFLKNSFKISVVSVLLILTFVPSVSFSIARNFERRYYKTIYYYLLMGLFIPSQVIMLPVTKMMTKLNMLNHTGLIILYSAFSLTQGVFLFVNYIRGLPYEIEESAYIDGCSVFQTYVKIVLPLVKPMIATLLIMDALWIWNDFMLPLMILNRSQNIWTLPLFQYNFKTEYSFNYTMAFTAYLLSMLPMLIIYCLGQKYIIKGLTAGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K364</accession>
    <name>F7K364_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250242.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00293"/>
    <dbReference type="EnsemblBacteria" id="EGN33434">
        <property type="protein sequence ID" value="EGN33434"/>
        <property type="gene ID" value="HMPREF0994_00293"/>
    </dbReference>
    <dbReference type="GeneID" id="29726776"/>
    <dbReference type="HOGENOM" id="CLU_125825_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="84" mass="9594" checksum="6E538614FAF2FC90" modified="2011-09-21" version="1">MIFFSIVFLLSALILAFILLLRSRTGFERILYVSLISTLIAAEIVLYAVYAGEEMYLDVALVFALLGFMDVQFFSVYLRRKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K390</accession>
    <name>F7K390_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33460.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00319"/>
    <dbReference type="EnsemblBacteria" id="EGN33460">
        <property type="protein sequence ID" value="EGN33460"/>
        <property type="gene ID" value="HMPREF0994_00319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN33460.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="423" mass="45515" checksum="A1FE1C32E52BD4BB" modified="2013-09-18" version="2">MMNNTKKYGKDFTLVVVGQIVSLFGNAILRFSLPLYLLRETGSSTLFGIVTACSFLPMIVLSLLGGVLADRVNKRNIMVCLDFLTAGVITVFSWLLGIVPIIPLFITVLMLLYGISGTYQPAVQASIPALVPKEKILSANAIVNQIGALANFIGPIIGGMLYGAFGIVIILKVSVLCFVLSAVMEIFIKIPFQKQPTQDKVLQIAAGDLRDSIRFLRMEKPLFVQICIVIAGLNLFLSPMLTIGIPVIVVDKLHLTDGLLGLTQGMLAVGGILGGLLTVLLDKKLTPQTAYVPLFLCTACSCLMGFGMAIGQSPMIKYVILSVTGLSVTIFTTMFSIQMLAVVQAETPQHLIGKVVACIMTFIMCVQPIGQLLYGFLFECLPSQPVIIIGASMISLVIAVRSKKILIKLGGSNHYDEYSSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3Q3</accession>
    <name>F7K3Q3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrD_C_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250431.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00482"/>
    <dbReference type="EnsemblBacteria" id="EGN48200">
        <property type="protein sequence ID" value="EGN48200"/>
        <property type="gene ID" value="HMPREF0994_00482"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.530"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015011_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD_C_2" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1098" mass="127084" checksum="B018399C0D897DB7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3R3</accession>
    <name>F7K3R3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00492"/>
    <dbReference type="EnsemblBacteria" id="EGN48210">
        <property type="protein sequence ID" value="EGN48210"/>
        <property type="gene ID" value="HMPREF0994_00492"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z83H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2155088_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="111" mass="11803" checksum="3EF74A18343D1207" modified="2011-09-21" version="1">MLPLYYPIENLIPNFTNTFNVYLRMDGGTGQIETGGCIASISGQGMAAAPAWDGKITLEENIPLFRVGGGMIVKGFSETIGVETMELVQRQMVDSIARIGIGAFGTVVDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3U4</accession>
    <name>F7K3U4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliP</name>
        <name evidence="13" type="ORF">HMPREF0994_00523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250472.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00523"/>
    <dbReference type="EnsemblBacteria" id="EGN45527">
        <property type="protein sequence ID" value="EGN45527"/>
        <property type="gene ID" value="HMPREF0994_00523"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.572"/>
    <dbReference type="eggNOG" id="COG1338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042028_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN45527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="246" mass="27462" checksum="CCBA6775B94AB3DD" modified="2011-09-21" version="1">MLSVLAAFLYAGRVYAAEVSMTLSDTQGNARAFDTMDILILFLLLAVVPSLLVMMTSFTRIIIVLSFLRSALGTQQSPPNQILVGLALFLTLFIMQPVFSQVNTQAYQPYKDGTLTREEALELAQDPMKEFMLKQTEKKSLELFMDISKTELPEIKAGEGPERYKQLGLTVIVPSFILSELNKAFTMGFLIFIPFLIVDLVVSSTLMSMGMVMLPPTMIALPFKIMLFVLVDGWDLVIKTLVEGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4T7</accession>
    <name>F7K4T7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250815.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00866"/>
    <dbReference type="EnsemblBacteria" id="EGN43175">
        <property type="protein sequence ID" value="EGN43175"/>
        <property type="gene ID" value="HMPREF0994_00866"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.944"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="32655" checksum="22BD6AABC6890199" modified="2011-09-21" version="1">MDCIQSIQKAIDYMEANMLENISYEDAARHLHMSNYHFHRLFSMLTGMTANEYIRSRRLSMAGQELIMSDAKIIDIALKYGYDSPDGFAKAFYRFHGVTPNMAKQPGAGLQLFNRLVINITWKGGMVMEYRIVEREKFKVLAKVEQFRNSSIDEEGNTEIPDFWKKCGEEGVFDTLTACTGKGDIYGVCGPVSRECDFFSYGIGKEYEGGDVPDGFCVWEINPTLWAVFSCIGKDGDCIGETWDRIFKEFLPGSDYNMKDDDDFELYLENPAPGCFCEIWIPVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K516</accession>
    <name>F7K516_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250901.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00952"/>
    <dbReference type="EnsemblBacteria" id="EGN43261">
        <property type="protein sequence ID" value="EGN43261"/>
        <property type="gene ID" value="HMPREF0994_00952"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1040"/>
    <dbReference type="eggNOG" id="ENOG5031KJ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145230_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="146" mass="17188" checksum="333F445340680F7E" modified="2011-09-21" version="1">MAEKNNSNLFFTCSVIEFIGRKMLLPRRSAVDALGKEAVERIYDYADVFHCEPIEKVAAEFIEEYKIPAGEFDNVTDCRYRVPDYWTIGEVYERLIEDCFSDDRIKDGIWEVYHSWMDSHLSDYNTDLYYQARDYIAACYKAGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K520</accession>
    <name>F7K520_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="5">AGPR</shortName>
            <ecNumber evidence="5">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="5">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argC</name>
        <name evidence="8" type="ORF">HMPREF0994_00956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00956"/>
    <dbReference type="EnsemblBacteria" id="EGN43265">
        <property type="protein sequence ID" value="EGN43265"/>
        <property type="gene ID" value="HMPREF0994_00956"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1044"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_9"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="7">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="392" mass="43806" checksum="F3382474F5A4407F" modified="2011-09-21" version="1">MACCPWEYTHGYTPAEIQENGWMQAKASHTEQKGMEKMIKAGIIGATGYAGGELVRLLTAHPEVEIAWYGSRSYIDKKYYEVYRNMFRIVDDKCMDDNMEELADLVDVIFTATPQGLCASLVNEGILSKVKIVDLSADFRIKDVKTYEEWYGIEHKSPQFIEEAVYGLCEINREAVRGARLIANPGCYPTCSTLSIYPLLKEGLIDPSTIIIDAKSGTSGAGRGAKVDNLYCEVNENIKAYGVASHRHTPEIEEQLSYAAGQEVLLNFTPHLVPMNRGILITAYASLMKEQLPDGTSVCPSYEKVRAAYDKYYDKEKFVRVLDKNICPETKWVEGSNYVDVNFKIDERTGRIIMMGAMDNLVKGAAGQAVQNMNLMFGMPEAEGLELVPMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5I9</accession>
    <name>F7K5I9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_01118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251067.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01118"/>
    <dbReference type="EnsemblBacteria" id="EGN42880">
        <property type="protein sequence ID" value="EGN42880"/>
        <property type="gene ID" value="HMPREF0994_01118"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1227"/>
    <dbReference type="eggNOG" id="COG2894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN42880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="262" mass="28795" checksum="B98A0E06B3F120B2" modified="2011-09-21" version="1">MSEVIVITSGKGGVGKTTTTANVGTGLAMLDKKVIMIDTDIGLRNLDVVMGLENRIVYNLVDVVEGNCRLNQALIKHKKYSNLCLLPSAQTRDKDSVSPEQMKELINQMREQFEYILLDCPAGIEQGFKNAIAGADRAFVVTTPEVSAIRDADRIVGLLEANEMSRIDLIINRIRMDMVKRGDMLKVEDVNDILSLPLIGVVPDDEQIVVSTNQGEPLVGGASPAGQAYLNICKRILGEDVPFLDLDKKGMLSKFKNMFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5K3</accession>
    <name>F7K5K3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251081.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01132"/>
    <dbReference type="EnsemblBacteria" id="EGN42894">
        <property type="protein sequence ID" value="EGN42894"/>
        <property type="gene ID" value="HMPREF0994_01132"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1242"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="32872" checksum="005637F90795E246" modified="2011-09-21" version="1">MVGKNKTGQIVLNIIFILLCTAAVAPFLLLLSSSLTDEATLMREGYNFIPRVFSFNAYVYLFSSSMKIIKGYGITILVTVLGTTLSVLMTTLFAYPLSRKELPWRGFFAFFVFFTMLFNGGLVPTYMMWTQSFHIKNTLWALIIPGLLMNGFYIIMMRSFFQANIPDALIEAARIDGGGEYRILFQVVTPLSKPIMATMALMIGLGYWNDWMNSLYYITDDKLFSIQAILNTIITNIQFLTSGQSSAASSVNVANLPSIGIRMAIAVIGILPVLCIYPFFQKYFVKGIVVGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5R5</accession>
    <name>F7K5R5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251143.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01194"/>
    <dbReference type="EnsemblBacteria" id="EGN42595">
        <property type="protein sequence ID" value="EGN42595"/>
        <property type="gene ID" value="HMPREF0994_01194"/>
    </dbReference>
    <dbReference type="GeneID" id="29724840"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1307"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356428" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="404"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="537" mass="60086" checksum="CF2C963496CDC4C5" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5U3</accession>
    <name>F7K5U3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251171.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01222"/>
    <dbReference type="EnsemblBacteria" id="EGN42548">
        <property type="protein sequence ID" value="EGN42548"/>
        <property type="gene ID" value="HMPREF0994_01222"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1335"/>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025558_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="651" mass="73416" checksum="E158003F1A76C1BB" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5X4</accession>
    <name>F7K5X4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251202.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01253"/>
    <dbReference type="EnsemblBacteria" id="EGN42453">
        <property type="protein sequence ID" value="EGN42453"/>
        <property type="gene ID" value="HMPREF0994_01253"/>
    </dbReference>
    <dbReference type="GeneID" id="29725435"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1370"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="7">
        <location>
            <begin position="75"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="6">
        <location>
            <begin position="195"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_mannosidase" evidence="8">
        <location>
            <begin position="765"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="844" mass="96035" checksum="AE5D47525A933598" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5Y6</accession>
    <name>F7K5Y6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251214.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01265"/>
    <dbReference type="EnsemblBacteria" id="EGN42378">
        <property type="protein sequence ID" value="EGN42378"/>
        <property type="gene ID" value="HMPREF0994_01265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1382"/>
    <dbReference type="eggNOG" id="COG4586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN42378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="328" mass="37696" checksum="4C2D8D96C542D40F" modified="2011-09-21" version="1">MAVIRVEHLKKEFEYYKKGTGLQGSLHNLFHREMLKKEAVKDISFSVERGEMIGLLGPNGAGKTTTLKMLSGILFPTAGEVEIDGYIPWERKNAFKRRFSIVMGQKNQLWWDLPASDSFYLNKCIFDVPDGEYRRTVEELSELLDVKDLMNVQVRRLSLGERMKMEILAALIHRPDILFLDEPTIGLDILSQQKIRDFLKTYNEQTKTTVILTSHYMRDIEELCRRAVIINQGQLVYDGTLADINHRMGDRKLLSLKSIEPVPREHLSLFGRVREYHGREAVLEVPKGKIKETASAILSLLPVEDFTVTEIPLEESISLFFQKEVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K698</accession>
    <name>F7K698_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01386"/>
    <dbReference type="EnsemblBacteria" id="EGN42248">
        <property type="protein sequence ID" value="EGN42248"/>
        <property type="gene ID" value="HMPREF0994_01386"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1506"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="389" mass="43845" checksum="8C2BD28F54C60257" modified="2011-09-21" version="1">MAGLAVLYETERKIKKKGAIMRLVIDCFKLVKGKGKSIGIYNLAQSLVQHLTAANKSGEHCEEIIVLGNEYNRKDFDIPGIRFVLMKGNPLNKLTCIVWELFLVPWKARKYGADRILFPRGYRPLFYRGKDTVIIHDLIPFYYDKHFPGVLNRFENAYIMSRLKASMKHADRIITISEFSRKEIDAMCPGSGSRVNVIYNGLNKVEASEEKCALSPQGPYIYATASKLPHKNAAGVLRTYDAYFHQTDDPVRLVVVGIPGTEEFEISEEAAAYVTCYKYIERTEDMHSLLAGARAFLFLSLIEGFGFPPLEAMQLGVPVVSSDRTALAEVVGDAGLLTDPDNYAQTVECLNRVLEDEELRAGLIQKGYANVTRFDWSSRIAAYWEELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6A4</accession>
    <name>F7K6A4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251341.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01392"/>
    <dbReference type="EnsemblBacteria" id="EGN42254">
        <property type="protein sequence ID" value="EGN42254"/>
        <property type="gene ID" value="HMPREF0994_01392"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1512"/>
    <dbReference type="eggNOG" id="ENOG5033PZT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782346_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="40016" checksum="DFA19230A30ADAEF" modified="2011-09-21" version="1">MVGTELLKGQGLGNQLFCYVTTRCIAMKQGRDFSILGSDTLANNIHSSCGLYFMDLDFGVKAEKKDFAGTYYERDDRIFTGSSRHDMTHGCYVTAADEGMFQVADNMLLFGNMQAEEYYIAYKKQIKQWLKVKPEYDCHDFTDENLCVLHLRCSDYMDSPELYLRKKYWLDGMKNMRKINPDMEFMIITNDVKEANKFLPGIPAYNFDLAKDYSILKNARYLLLANSSFAYFPAFTSDTVEYIIAPKYWARHNVSDGYWASEQNIYSGWHYMDRKGRVFSDEECRHELEAYKKKSGRYRRLNVKPGKLKSCLYKIQSKSIYTNARLHKIARGVIRRMKALKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6H1</accession>
    <name>F7K6H1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ORF">HMPREF0994_01479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251428.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01479"/>
    <dbReference type="EnsemblBacteria" id="EGN41953">
        <property type="protein sequence ID" value="EGN41953"/>
        <property type="gene ID" value="HMPREF0994_01479"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1612"/>
    <dbReference type="eggNOG" id="COG1089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="6"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="355" mass="40394" checksum="6CD9066758233C3F" modified="2011-09-21" version="1">MKNVALITGINGQDGSYLAEFLLEKGYEVHGLVRRHSISVTSRIDHLIHSPYNNVKFFLHYADTTDSSALMRIMAEIRPTEVYNLAAQSHVGISFEVPEYTADATGMSTLKLLEAVRINGGPCRFYQASTSELFGGLPETAPQSEKTPFYPKSPYGVAKLYSYWITVNYRESYNMFACNGILFNHESPRRGENFVTRKITLAIAAILAGKQEKLSLGNMNAKRDWGFAGDYVEGMWLMLQQEKPGDYVLSTNETHTVREFVEEAFREVGIEVRWEGQGVNEKGYDSQTGKLLVDVNPEFYRPAEVEYLWGDCTKAEKELNWKRKVDFRGLVAMMMNADMQEIVGMSCEEFRNRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6J1</accession>
    <name>F7K6J1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-terminal processing peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251448.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01499"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="EGN41973">
        <property type="protein sequence ID" value="EGN41973"/>
        <property type="gene ID" value="HMPREF0994_01499"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1636"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="111"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="415" mass="45007" checksum="6878695A5606AB34" modified="2011-09-21" version="1">MNHKKSFWGGVITGVLAAALIVSGVFLGQSVWNLYQSSRTQETAAQNEEDGVSSNSVANAQTMNKLQVLEDTIDRYYLENVDEQTLEKGVYDGLVEALGDPYSTYYSSEELKELQDKTEGIYYGIGAYVGIDADTSLPRLTGIIEGTPAQESGLRAGDLLYKVDGEEVQGLELTQVVSKIKGEEGTSVHLTIIREGATDYLEVDVVRRKVESPTVNQKMLDGGIGYIQITEFDTVTLDQFTEALAVCRGSGMKGLILDLRGNPGGNLNTVCDIAREILPKGLIVYTEDKDGKRSEYTCDGTKEMKEPLVVLVDSGSASASEILAGAVKDYGIGTLVGTTTFGKGIVQRIISLSDGSAVKLTVSNYYTPNGNNIHKIGIEPDIEEKFDSEAYYNDGVDNQLNKAIEIMNEKLGPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7E6</accession>
    <name>F7K7E6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41588.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01775"/>
    <dbReference type="EnsemblBacteria" id="EGN41588">
        <property type="protein sequence ID" value="EGN41588"/>
        <property type="gene ID" value="HMPREF0994_01775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363782" description="ABC transmembrane type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="58"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41588.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="31938" checksum="00F12463C2BC274A" modified="2013-09-18" version="2">MFLFTAPVIILFCLIIVIPLAESAAMSFTEWDGVNEAVFTGLDNFKRLFTSRDLKVSIRNSLLYSGVLTVYQIGLGTLFAFFLANFNIKGRRFFKDVYFFPVLLSVSVVAQLWISVYHGDFGLINQLARHLGVNWEQNWLYEPVKGVIAIVLAESWKGMGYHMLIIYAAMKNVPDVYYEASYIDGANKRQQFFNITLPLTIPTIKVCVVMCITYGFRAFEMIFLMTGGGPGNSSYTMPIMMYKALFGLQKYGYGSAIAVVIVIICVGMMLGINKLTERFDGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7H6</accession>
    <name>F7K7H6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251718.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01805"/>
    <dbReference type="EnsemblBacteria" id="EGN41618">
        <property type="protein sequence ID" value="EGN41618"/>
        <property type="gene ID" value="HMPREF0994_01805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1970"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="33974" checksum="08595BF94B3D921F" modified="2011-09-21" version="1">MVRYFAKRFGMMLVAMFLIILLTFVIMHSIPGGPFTSDRKVSEEVEAALNEKYHLDRPLPVQFFEYLGGVLHGDLGPSYKYTGKEVSEFIKNGFPVSAKLGGITIIFVMLAAVPMGILAAVKNGKWQDMLVMSLATIGVTIPSFVIASLLIYFFSYKLNWLPTFGLDSWKGYILPVIALGGYSLSYMARLMRSSLLEVMGQDYIRTARAKGLSETSVILKHAMRNALIPVITVLGPTIANMMTGSFVIEKIFAIPGLGVHFVNSVSQRDYTTIMGVTIFYAAFLMAMIFIVDIFYCLIDPRIKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7U5</accession>
    <name>F7K7U5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251904.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01991"/>
    <dbReference type="EnsemblBacteria" id="EGN41396">
        <property type="protein sequence ID" value="EGN41396"/>
        <property type="gene ID" value="HMPREF0994_01991"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2187"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057667_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="267" mass="30858" checksum="03FFE332C6FEA893" modified="2011-09-21" version="1">MNIEIANRLVTLRKRNSLSQEALAEKLGISRQAVSKWERAEASPDTDNLILLSRIYGISMDELLSTEDEIPVSYMDMEEEKLPEKEIREEEGEILSPEKEPDEYVHIGLSGIHCKDKDSEVHVGWKGIHVIEKDKDEVHLDSNGIYVNGKRYDSHFFREWAGVEFPFTLLVIAAFIAIGVLTGAWHPAWVIFFTIPLFHSCVEAFRRKDMGWFAFPVLIMMIYLLLGIFKSLWHPGWLLFLTVPVYYAIVGFIRTRKEKQLQDDESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7V0</accession>
    <name>F7K7V0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251909.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01996"/>
    <dbReference type="EnsemblBacteria" id="EGN41401">
        <property type="protein sequence ID" value="EGN41401"/>
        <property type="gene ID" value="HMPREF0994_01996"/>
    </dbReference>
    <dbReference type="GeneID" id="29728099"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2192"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026152_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="178"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="43242" checksum="3795EB97BA6A9EB9" modified="2011-09-21" version="1">MLIIWIVFGAVFLFYLQKWIYGHYWEKDLSAELSFSRESAVEGEVCQLSERVENGKLLPLPMLKVKFQVSRKLRFSDEGDGAVTDKYYRNDILSLGPRQRVIRTIPFVCGARGYFRLREMDLVAADLFLTREMISSATADSTLYVYPAPVSGVELDSALQKLNGEILAKRHMLEDPFEYRGIREYAPYDEMKTINWKATARTGDLMVNIRNYTSLRAVRIFLNLADTGILKNEQLVELCISIAARFAGELLEQGIRVAVYANGRDVLTGDPMKMQPSAGPGHMESINRAFARISLEEGVYPFGELFRGELEEEGKDMATLFLSVDRSPEFQEDIRTFARMGTDFTWMCPLFPRMESHVEEEEALHFIRLDAEEMLNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K815</accession>
    <name>F7K815_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02062"/>
    <dbReference type="EnsemblBacteria" id="EGN41467">
        <property type="protein sequence ID" value="EGN41467"/>
        <property type="gene ID" value="HMPREF0994_02062"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2263"/>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051472_6_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356710" evidence="4">
        <location>
            <begin position="33"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="337" mass="36474" checksum="9D0A3F06AAE75B4B" modified="2011-09-21" version="1">MRRKNYMVCAAALTMIIGIMAVLPGCGPTVRAESGSAPDAAQEVNTAQEESAAQDGSTAQGGAGLQTEDWPEEITVVQMPNENNPNVGQKHEEFSRAMEEALGIKVKEMEGTEYSVGIEGMASCNIDVMLVSPMSYYQAKERANAQLLVSTPMASEYYTAFITQADNEEINTLEDLKGKTFAFVDQASSSGYMYPKAKLVKELSLDPDLLENSGYFFDTVAFAGQHPSVATGVAMGDYDAGAVAASVIDQMVQAGALEDGKLKVIERTDTIPNPAYVVRGDLPDSLKAKLKEFFLNYSDAGYFAEVHGDPSIRFVDVSEEDYKVVYDTLEALHIEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K840</accession>
    <name>F7K840_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252000.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02087"/>
    <dbReference type="EnsemblBacteria" id="EGN41492">
        <property type="protein sequence ID" value="EGN41492"/>
        <property type="gene ID" value="HMPREF0994_02087"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2291"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070745_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="333" mass="39081" checksum="8ED6C61B6F262757" modified="2011-09-21" version="1">MAIKTCVSLYSLQDEYMNKRMTLEDIMKYLAENKVEGLELLPDQMIHNTPHPSEESLKHWDYLMETYKIKPVCSDVFLNTNLYNNRTLTKRECIDLLIDEIKLAHRMGFHLIRFVSMVPAFVIEPLLPYAEKYDVAFALEIHAGMSFGIPETRGFIEEMIRVDSPYCGLVVDAGIFCRRIPRVYNDYNMKVLGTNPKVVDYFNSLFDKGLDGTHAFDEHHNMKPELAAIASEKDMPYIMLADGYENTPYETLDKYMKYIRHFHFKLWEMADGEEYSVDYKGLLQYLHDHDYDGYVATEYEGNRWILPGHPMVEKEQVAAHQEMIRRYIQEMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8B8</accession>
    <name>F7K8B8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251804.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01891"/>
    <dbReference type="EnsemblBacteria" id="EGN41296">
        <property type="protein sequence ID" value="EGN41296"/>
        <property type="gene ID" value="HMPREF0994_01891"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2073"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="227" mass="25987" checksum="3421517E1A993DDB" modified="2011-09-21" version="1">MKAEENTNDYLPLRDVVFNTLRESILKGEMKPGERLMEIHLANKLGVSRTPIREAIRKLELEGLVTMIPRRGAEVAQITAKSLRDVLEVRQALDALAMELACERISEEEIGKLRQACDNFAEITKTQDAVQIAQADVELHDIIVQGSRNEKLAQMVSNLSQQMYRYRLEYIKDVSQHGRLIEEHEEIYRCISSRDKNAGAKAIKMHIYNQEQSILNQIQQNKGTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8X1</accession>
    <name>F7K8X1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252032.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02119"/>
    <dbReference type="EnsemblBacteria" id="EGN41026">
        <property type="protein sequence ID" value="EGN41026"/>
        <property type="gene ID" value="HMPREF0994_02119"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2321"/>
    <dbReference type="eggNOG" id="COG2105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2012287_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025463">
        <property type="entry name" value="DUF4314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14192">
        <property type="entry name" value="DUF4314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4314" evidence="2">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="123" mass="13906" checksum="B314B25C9F29EF2C" modified="2011-09-21" version="1">MNEWEKNRRMAESYRQSYPPGTRLELIGMDDPFAPIPAGMRGTVNYVDDQSQIHVKWDNGSGLALIPDTDSFRRLSAKEIEAENAAKGSVVSRLTASKTQPGKEREEGRRQAKPNKKKEDMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8X6</accession>
    <name>F7K8X6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-E processing peptidase SpoIIGA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252083.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02170"/>
    <dbReference type="EnsemblBacteria" id="EGN41077">
        <property type="protein sequence ID" value="EGN41077"/>
        <property type="gene ID" value="HMPREF0994_02170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2375"/>
    <dbReference type="eggNOG" id="ENOG50301AF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059158_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005081">
        <property type="entry name" value="SpoIIGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03419">
        <property type="entry name" value="Peptidase_U4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="31353" checksum="2635BA7A6653C618" modified="2011-09-21" version="1">MRYVVYIDRLFLLQFVQSCILLLLTRAFLHSTAALKRIVFASAAGALLFCMILLLPDAGRRMKILLFACSSLVTLGMAFRIRTLQHFCKAVILYHGAAFLLAGALNALYGAFGRAPFMDTIQASACAATIGVTVLCVLRWEKIKREEIVITVILEEGSVQVTLKALIDSGNSLYDPISGKPVCVVEREALEGKIPLDIPEKFRLIPYHSIGKKHGMMQAVEIEKLKVKKDGQELIVEKALLGLYENKVTAHGGYQMILHPALFENRRNGHDIKSRNTRKNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K957</accession>
    <name>F7K957_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252298.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02397"/>
    <dbReference type="EnsemblBacteria" id="EGN40796">
        <property type="protein sequence ID" value="EGN40796"/>
        <property type="gene ID" value="HMPREF0994_02397"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2626"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="454" mass="52340" checksum="9C4E0160835FA6B0" modified="2011-09-21" version="1">MKNVLIIMTDQLRRDVLGCYGGKEVETPYIDSLAEEGILLENCYTPSAVCTPSRGCFMTGRYPHNNGAISNGRPVGAKEHGFAEAFRDAGYVTGYAGKWHLGDHRELGDSLEDCSRLGFDRWDHRVEFGHCKSVKEKDGKLILSREVGDEHSYTTDWLADETLRFIKEQKDGRPFLFMVSMPDPHQPFRVRKPYDTMFDPLQMEIPETFYEEELPDWAEQDEWGRRHYFPTGLFEREDHFRRLKAQYLGAVKCIDDNVGKILDGLREANLLEETVVIFTTDHGEYLGEHGLMEKNNLYESVYHIPMLLRLPGCGKKGFRSPVWLRMTDFAPTLAGLLGIPYRFPCDGGDLSEELMKGREGLKEVCIFPSDVPRTGIITEDYELAYVGRGYHGSMFHDHILFDRKRDPMQRVNLFGRPEYAGITEVLTEKIREYHRRYRTPDSLLPAEARNLQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9I1</accession>
    <name>F7K9I1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40941">
        <property type="protein sequence ID" value="EGN40941"/>
        <property type="gene ID" value="HMPREF0994_02542"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2786"/>
    <dbReference type="eggNOG" id="COG2746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060091_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="271" mass="30375" checksum="C295F0ACF1640D81" modified="2011-09-21" version="1">MIYTRKELQNQLKGMSLRPTDSILIHSSMKAMGNIEGGADTVLDALMDYFSQGLLLLPTHTWAQMGEEYRVFDPVKEDACVGILPNLFRKRPGVCRSLHPTHSMAAYGAGAEEYIAGEEENNTPCTPGGCYDRLKDINGRILLVGVTHARNTFIHGVEEVLNIPNRLTEKPVEFYTVMPDGSRKKIFMRRHYNAVQPYISEDFVKLTQAFYDTGAARQVLFGNAECILCDARGIFEVTRHILAPDPECIITSPEIPASRWSDFTGGPYFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9I7</accession>
    <name>F7K9I7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40949.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359753.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02550"/>
    <dbReference type="EnsemblBacteria" id="EGN40949">
        <property type="protein sequence ID" value="EGN40949"/>
        <property type="gene ID" value="HMPREF0994_02550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40949.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="277" mass="32618" checksum="7EAD443262705BE0" modified="2013-09-18" version="2">MITNEYINRAIDYILNHIDEEITVEDISNYCCFSRYYFSRIFKMETGESIYEFIKRVRMERSAFRLKVEKDRSITDIGSAYGYSSSNYSSAFKKHHNMPPYKFRRSIVHKSMMNPVFRNTQTELLTWQECSEKISVEMFEDCTVIFERYKGSYGDLSVHWGDFLDKYKEYITEQTRILERSYDDPAITLPDKCLCDICIDAPTGCTLENICTIKGGRFAVYHFSGPVEHIYSAYQNLFSVWLPQSKYKIDDSYGFEIYKKTDCGSMHMDIDICIPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9K9</accession>
    <name>F7K9K9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252480.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02579"/>
    <dbReference type="EnsemblBacteria" id="EGN40978">
        <property type="protein sequence ID" value="EGN40978"/>
        <property type="gene ID" value="HMPREF0994_02579"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2825"/>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100195_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="27243" checksum="DBC6ABDA320DCE6A" modified="2011-09-21" version="1">MTDTKKVLIFKGGWDGHEPDLIAERFAGIMEKNGYSCVIYDNQEVMLDLELVMSQDLIIPCWTMGEIDTKVRENIVKAVAAGTGLAGCHGGMCDAFRNDVEWQFMTGGQWVSHPGGDGISYEVNIRKGSSPIVEGLEDFPVCSEQYYLHVDPAVEVLATTRFPVVPYYHISNKVVDMPVAWTKFWGNGRVFYNSLGHHDDVFDKSPSAQILMERGMLWAAEGKQYAAEHGLTTERFENTAKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA26</accession>
    <name>F7KA26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252610.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02709"/>
    <dbReference type="EnsemblBacteria" id="EGN40692">
        <property type="protein sequence ID" value="EGN40692"/>
        <property type="gene ID" value="HMPREF0994_02709"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2965"/>
    <dbReference type="eggNOG" id="ENOG502ZCD3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1516452_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="177" mass="19917" checksum="596291E4A3BC40ED" modified="2011-09-21" version="1">MNEANNRDSEFLGYEYKELSVEQSRVSMYLDGYKNFGWIADDNFDLPKAGSMATLHLKRNRKIMNKMELTRLQRNFEACMNEIETLERSKTANARIASLTAGVLGTAFMAGATFAAVASPPIIWLCILLAVPGFSGWIAPYFLYKKLVQKRTAKVVPLIEAIYDEIYDLCLKGSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA62</accession>
    <name>F7KA62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252511.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02610"/>
    <dbReference type="EnsemblBacteria" id="EGN40593">
        <property type="protein sequence ID" value="EGN40593"/>
        <property type="gene ID" value="HMPREF0994_02610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2861"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="5">
        <location>
            <begin position="375"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="488" mass="56086" checksum="09C8686B0FFA3F4A" modified="2011-09-21" version="1">MKKLNILWICTDQQRADTLGCMGNEWVCTPNLDRLAAEGVVFENAYSQSPVCAPSRGSFLTGRYPRTCGPRQNGQDIDAGERLFPKMLADRGYYCGLAGKLHLSACHPDTGRLEEPRIDDGYHVFRWSHHPQPHHGTNWPSNAYNQFLLQNGRDYITPDREDCPYVQTGVEEKWHQTAWCADEAIAFMETARTYGKDWMFSLNCFDPHHPFDPPADYLERYLDKLEQLPLPNYEEGELAEKPVFQQKDHEGAYDTKGYYMYDNMNDHDHRLIKAAYWAMVDLIDKQVGRLLDYLDKSGQREDTLILFHSDHGENLGDHGMYLKGPYFYENNVHVPLIISWPARIPGGRRSRALVELTDLAPTLCEAAGLPVFEGFQGKSFWKLLTGETDLHTHRSSVYSEYYNSNINHRDPLAFATMVCDGRYKLVRVHGDMGKTAGGELYDLEEKPLERKNHYQDPGLAEVKMRLLETMCDRMAQTCDPLPVRKACW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBF7</accession>
    <name>F7KBF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YgiT-type zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253092.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40021">
        <property type="protein sequence ID" value="EGN40021"/>
        <property type="gene ID" value="HMPREF0994_03191"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331DJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174612_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="75" mass="8405" checksum="D1180C2FCC639C37" modified="2011-09-21" version="1">MKCFLCKGDLEKSTTTYMTDYNNCYIIIKNVPCTKCTQCGEVYLNGVTVQKIETIIQRLKAALTEIAVVDFTQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBF8</accession>
    <name>F7KBF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40022">
        <property type="protein sequence ID" value="EGN40022"/>
        <property type="gene ID" value="HMPREF0994_03192"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3486"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="473" mass="50750" checksum="EA5AA8AD0D45ED68" modified="2011-09-21" version="1">MDSPGNVTYNKISERQDSKKCLKGEDMKKYSRENIQTVLKMAWPSVLESFFVALVGMVDSLMVSRVGAHAVAAVGLTTQPKFIGLAVFIAVNVSVSALVARRKGQKNQKGANEVLCAACFFVLIMSVIVSLACVIFADPIIRMCGSEEASHTEAVQYFRIIMGFIIFTVISLTVNAAQRGAGNTKIAMKTNVAANVVNVIFNYLLIEGHFGFPALGVSGAAIATVIGSMVGCIMSIVAACKNDFISFPYMWREKIRPTLEVGKSMVKLGASVLAEQLLVRVGFLSVAVMAAKMGTAAFAAHQVGMNVMSLSFSFGDGMQVAAVALIGQSLGAKNVDMAKTYGSICQNIGRMIAAVLAVVYLTCGGYLYNLFFSEPEIIAMGVEIMRVIVVVVLLQIAQVIYMGCLRGAGDVIYTTIASTVSVTIVRPIASYLLCYTAGLGIIGIWFGVCADQLVRFILTSLRFRSGKWTKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBN7</accession>
    <name>F7KBN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253175.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03274"/>
    <dbReference type="EnsemblBacteria" id="EGN40104">
        <property type="protein sequence ID" value="EGN40104"/>
        <property type="gene ID" value="HMPREF0994_03274"/>
    </dbReference>
    <dbReference type="GeneID" id="29728397"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3578"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="229"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="343" mass="39908" checksum="D8F7DCC2CF70083F" modified="2011-09-21" version="1">MEKERNAENRISLERIAPYVRYVNYKIFDGGTLLPERIIYDHEFIYCLSGEARFLYDGKTYTVKKGELFYICPYLHNTMLVPEGKTFRVHCVHFDWISPEAQYDFRAEQVYLHMENPPADAEGSDAFYMNSYKANNPYHNSLPPIKEERLLERPNPEVDPALFPPLITGLDYDTTAPLFKELYQNYSQLSTGARLRERSLFLQLAAAVCDLTSPVREDSCGLFHQKTISEAVNYIQEYYTEDISLPLLAAHSGLSQKYFGRLFREQTGYTVREYLTGVRIRNAKHLLSHTDSSLEQVALSTGFQDKFYFTKVFKRQTGITPGKYRKSYGHLDEMKQGEQAFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBW4</accession>
    <name>F7KBW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253262.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03361"/>
    <dbReference type="EnsemblBacteria" id="EGN40191">
        <property type="protein sequence ID" value="EGN40191"/>
        <property type="gene ID" value="HMPREF0994_03361"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3673"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="380" mass="43331" checksum="1EFD266FBABF28A3" modified="2011-09-21" version="1">MEKREELQQEKKKWLEEVYGKICTKMSAECTRVGDRIPYIPENGRYEGDLAETDVCWWTNGFWGGILWQMYHATGEEKYRLAAEGVENKMDAAFTSIGKLNHDVGFMWLHTAVADYRLTGNPKSRERGENAANILAGRFNPLGKFIRAWNGDSNIGWMIIDCMMNIPLLYWMSEENKDPRFKSIALMHADTAMEKLVRPDGSCNHIGIMDPLTGDLLEAPGGQGYEENSSWSRGQAWALYGFALSYHHTKEVKYLDAAKRIAHYFIANAAMTDYLPLCDFRAPEEPVFYDSTAGACAACGLLEIAGFVPENEKKLYEDSAYRILRAMEEHFANWDENVDAILEMGKVAYHGEAGQEAIIYGDYFFIEAILRMLDKDCFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC34</accession>
    <name>F7KC34_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03413"/>
    <dbReference type="EnsemblBacteria" id="EGN39920">
        <property type="protein sequence ID" value="EGN39920"/>
        <property type="gene ID" value="HMPREF0994_03413"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010853_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="278" mass="31733" checksum="0FA3D7F20752C368" modified="2011-09-21" version="1">MPTYTLGCQRQISAANYIYYADGCPHPDRIMQEHDFVYMINGEWEILQNEVPFTAMNDDVFILHAGQHHSGNKNCTPGTRTIYFHISCSPQDSFGSNPSAPGTTLPPLIHCSSFPRVKLLFQELISVRLSPSPNKDRKINALFDLLLLELQDSCAQNPHTQDTLLTQAITLTAQNPQKFYKTADMALHLGVCPKTLNQRFREAYAKTFYQYQMEEKIHLVQQFLLDYPDSKLQTVALNFGFYDEFHLNKIFKKHTGTPPGLYRKTLTATPFRPTLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC86</accession>
    <name>F7KC86_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253366.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03465"/>
    <dbReference type="EnsemblBacteria" id="EGN39538">
        <property type="protein sequence ID" value="EGN39538"/>
        <property type="gene ID" value="HMPREF0994_03465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3789"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="456" mass="49449" checksum="153B00F971E47567" modified="2011-09-21" version="1">MKKENKVFYKKLLFLVVPIALQNLMSAMVSASDAIMLSLLDQDSLSAVSLAAQVQFVLSLFWAALTIGATILAAQYWGKKDIQAVEWILAIVLKFSVLVSFVFFAGAIAFPRMLMRIFTNDDTLITLGAVYLRTVSWSYLFAGVSQIYLCIMKNSGRTGRSTVFGSVSMGMNILLNAIFIFGLLGVPKMGIRGAAVATVLARGIELFLVLAECARKDVVRIRLKYLRSSNPVLLKDFWHYTSPVLANELVWGCGFTMFSVIMGHLGSDAVAANSIANIVKNLIACLSLGIGSGSGIIVGNELGTGALERAKEYGGRLCRLALLAGAASGLLLLLCSPLILAVSGNLSRQAGGYLQGMLIMCSYYMIGKSINSTVIAGIFCAGGDTKFGLLCDLITMWVIIVPVGIIAAFVLKLPVLAVYFLLNLDEFVKLPAVYCHYRKYKWARNLTRDMSRSDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCW3</accession>
    <name>F7KCW3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253593.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03692"/>
    <dbReference type="EnsemblBacteria" id="EGN38856">
        <property type="protein sequence ID" value="EGN38856"/>
        <property type="gene ID" value="HMPREF0994_03692"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4030"/>
    <dbReference type="eggNOG" id="COG2040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062282_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="34749" checksum="F286DE236719CBC9" modified="2011-09-21" version="1">MGKTQLEICFDSNKLILTEGAVGQRMEHEFSLKPDADIMYASLIYSAEGRDALAAIYRSYLQAAEDYRLPILLMTNTRRANKDRVLRSEYRDKNMMRDYACFLRELASGYTCPVFIGGMMGCKGDAYSGSEGLSTDEAIEYHSWQRNMFDTDSIDFLFAGIMPALPEALGMAEVMEESKLPYIISLMINEHGTLLDGNTIHEAISVIDTHTEANPLCYMTNCVHPAILRSALSQPENRTEAVRARFCGIQANAACLSLQELDNSCALKTSDAKELAEEFRLLHRDFPLKIYGGCCGTDESHIREMIKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCY9</accession>
    <name>F7KCY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253619.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03718"/>
    <dbReference type="EnsemblBacteria" id="EGN38882">
        <property type="protein sequence ID" value="EGN38882"/>
        <property type="gene ID" value="HMPREF0994_03718"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4058"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="292" mass="31796" checksum="B99D3D6633894C37" modified="2011-09-21" version="1">MDNCNKEEAFPTSFPPQHQCRQPGIEWEMRPRPVFEDPCYTGSCKLKGKTALITGGDSGIGRAAAIAFAKEGANLAIVYLNENEDAKETKKRIEELGRECILLCGDIRRESVCRQMVESTVSEMGSLDILVNNAGVQFPQNSIEDITEEQLRTTFQVNLFPMFFFVKAALPHMKRRDCIVNTASVTAYEGEADLIDYSATKGAIVAFTRSLSLSLADRGIRVNAVAPGPIWTPLIVSSFTAEKVAVFGQDVPMKRAGQPCELAPAYVYLASGDSSYVTGQVIHVNGGTITGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD43</accession>
    <name>F7KD43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN38743">
        <property type="protein sequence ID" value="EGN38743"/>
        <property type="gene ID" value="HMPREF0994_03772"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_221085_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="29" mass="3487" checksum="D7A84DD83C86CABE" modified="2011-09-21" version="1">MKVPGDSHQKKSCYIDEEIENDLNKDYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDC8</accession>
    <name>F7KDC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase (NADP+)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253762.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03861"/>
    <dbReference type="EnsemblBacteria" id="EGN38626">
        <property type="protein sequence ID" value="EGN38626"/>
        <property type="gene ID" value="HMPREF0994_03861"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4204"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="340" mass="38348" checksum="B9013C1E4E8EADF0" modified="2011-09-21" version="1">MSEVIEQNKIPRRALYTGETIPAVGLGTFGSDKYGPEQVSEAVYGSIKAGYRLIDCAAVYQNEDRIGEVLKRVLEEGIAERKELFVTSKVWNDMHGEGQVLESCRKSLQDLQLSYIDLYFVHWPFPNYHAPGCDGDSRNPDSRPFSAEEFMSVWRQCEQLVEEGLVRYIGMSNMTVPKLKAVLPLCKIKPAALEMELHPGFQQPELFDYAVSQGIQPIGYCPIGSPSRPERDRTAEDVADTQMPEIVEIAEKHNIHPALVCLKWAAQRGQIPIPFSVKEPQFVSNLKCITEDPLTEEEMETIRKADKNCRLIKGQVFLWPGAKDWEDLWDLDGEITGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDS0</accession>
    <name>F7KDS0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253900.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03999"/>
    <dbReference type="EnsemblBacteria" id="EGN37688">
        <property type="protein sequence ID" value="EGN37688"/>
        <property type="gene ID" value="HMPREF0994_03999"/>
    </dbReference>
    <dbReference type="GeneID" id="29729259"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4356"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532944_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN37688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="511" mass="57478" checksum="9CDB662E6A618D4D" modified="2011-09-21" version="1">MKHPNIVLFLAEDLDFEGLNCYNPETTGYTGLIRARNPFASSTQKPTGRLLTPAIDSMAGDGVMFTNYYCTSPICTPARYTVMTGRFPERSPEHGEIFGNGPSTVWFNSPVCPGETLIPKALKTAGYQTAIFGKWHNYPLPVRNELNRLYHAFPEEASWEDPEVKKRVHEGYQYAVDYLKNNDYGWDTVDRIYYENPEPYLPVSISSHNIDWVIEGADDYIRSRTGQTDPFFAYIAVSIPHSRYSGKRFREANPLSSPAGLLDRPPHVLPPRHQIRERILTAGMAESACEGLWLDEAVKAIRNAIDAIGATEDTCFIFTTDHPTAGKGSCHLGRIPLIMFWPHHLEGGGTLSHLLSETDLAPTILELAGCNVPPDMRLDGHSFAGLLQPHISSWTPRSNVLMENVNSRAVIQDGYKYIANRLPGRNALESELCGRTGWLAEQIGGHDGIWWNLDLLFPAYFDEDQLYNIEMDPMEQHNLASDPKNRTLLHSMQTTLSQELRKLPHPFGEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEB4</accession>
    <name>F7KEB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254094.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04193"/>
    <dbReference type="EnsemblBacteria" id="EGN36473">
        <property type="protein sequence ID" value="EGN36473"/>
        <property type="gene ID" value="HMPREF0994_04193"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4574"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="279" mass="31130" checksum="7721F862A22E43FA" modified="2011-09-21" version="1">MNARKAKHGGLLTFVFTLISLVYVFPIVLVVINSFKKKAYISRKPFAIPTDKMYVGLENYVNGIKKTGFVDAFWTSLFITVLSVAIIILCTSMCAWYISRVKNKFTTGLYFLCLFSMIVPFQMVMFTLSKLADMLHLGNPLGIVVVYLGFGAGLSVFMFCGFVKSIPLEIEEAAMIDGCTPIQTFFRIVMPILKPTCITVAILQAMWIWNDYLLPYLVLDMTKYKTIPIAVQYLRGGYGSIDMGAMMGVLVLAIIPIIIFYLVCQKYIIEGVVAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEE5</accession>
    <name>F7KEE5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254126.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04225"/>
    <dbReference type="EnsemblBacteria" id="EGN36505">
        <property type="protein sequence ID" value="EGN36505"/>
        <property type="gene ID" value="HMPREF0994_04225"/>
    </dbReference>
    <dbReference type="GeneID" id="29729756"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4612"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004617_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="721" mass="81444" checksum="D2E481B78497D823" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEJ2</accession>
    <name>F7KEJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254125.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04224"/>
    <dbReference type="EnsemblBacteria" id="EGN36504">
        <property type="protein sequence ID" value="EGN36504"/>
        <property type="gene ID" value="HMPREF0994_04224"/>
    </dbReference>
    <dbReference type="GeneID" id="29729757"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4611"/>
    <dbReference type="eggNOG" id="COG2362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086038_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="29367" checksum="44C818180C34DAE2" modified="2011-09-21" version="1">MKIYISADMEGISGITHKKFLSPGAEEYERGRKLMAGDVNAAIEGALLAGAEEIVVNDAHGTMRNLCIEDIHPAARLISGYPKPQMMMCGLDSSFDGAIFIGYHSRSGSGGVLSHTISGGVFQNISYNGRPAGEFAINAALAGAYGVPVILVSGDDCLQEEVKEWNPAIEYAVTKKAVNWSCADCLHPEVSARRIKEAAEKMVKGCREVPPVSLKDLDVEITYKYSGYALVSASIPGVEMVDAVTSRFHAADPIEAVDLLMAVSNASNVYSNGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEW6</accession>
    <name>F7KEW6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_04402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254303.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04402"/>
    <dbReference type="EnsemblBacteria" id="EGN35712">
        <property type="protein sequence ID" value="EGN35712"/>
        <property type="gene ID" value="HMPREF0994_04402"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4804"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="9">
        <location>
            <begin position="195"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="457" mass="52392" checksum="5024CF7B7059F847" modified="2011-09-21" version="1">MDKITFLGAGSTVFAKNVLGDCMMTEPLREFEYALYDIDPERLEESYLMLSNINKNSNGQKAKIVKYRDRREALRGARYVINAIQVGGYEPCTVTDFEIPKKYGLRQTIGDTVGIGGIFRALRTIPVMLDFAEDMEEVCPDALFLNYTNPMAMLTMAMLRASSIRTVGICHSVQVCVPQLLYRLGLPRDHVKYRIAGINHMAWLLEITRNGEDYYPEIKRRASDGPVYKPYTKEMLKDYPQLLYPDYEFTPEKHDDLVRFEIMKQFGCYVTESSEHNAEFMPYFIRKSHPELIEKYQIPLDEYPRRCRIQIEHWKQLKNQLVGNEKLTHTRTHEYPSYILEALETGRPFTFAGNVMNEGLIENLPKDCCVEVTCVAGQGGIQPCHVGNLPHQLAALNMSNIGMQQLTVDAALTRSRECIYQAAMLDPHTAAELTIDEIRSMVDELIEAHGSWLPEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEX9</accession>
    <name>F7KEX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254316.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04415"/>
    <dbReference type="EnsemblBacteria" id="EGN35725">
        <property type="protein sequence ID" value="EGN35725"/>
        <property type="gene ID" value="HMPREF0994_04415"/>
    </dbReference>
    <dbReference type="GeneID" id="29725200"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478018_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356570" evidence="1">
        <location>
            <begin position="29"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="577" mass="63771" checksum="9CA247827C2E8F03" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFE4</accession>
    <name>F7KFE4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="8">Glu-ADT subunit A</shortName>
            <ecNumber evidence="8">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gatA</name>
        <name evidence="10" type="ORF">HMPREF0994_04573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254474.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04573"/>
    <dbReference type="EnsemblBacteria" id="EGN35342">
        <property type="protein sequence ID" value="EGN35342"/>
        <property type="gene ID" value="HMPREF0994_04573"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4991"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="506" mass="53884" checksum="DD44D8BBBD41590C" modified="2011-09-21" version="1">MSLLECTALELADKIKKKECTCQDAVQAVFAQIEKQEKNYHCYISLDKERALKRAGEVQAAIDSGELTGPLAGVPVAVKDNICTEDVETTCASRILSGFVPTFSAEAVVNLEKAGAIILGKTNMDEFAMGSTTETSAYGVTRNPWNPEHVPGGSSGGSAAAVAAGECYFALGSDTGGSIRQPAGFCGVVGMKPTYGTVSRYGLIAYGSSLDQIGPLCRDVSDCAAVLEAISSHDTKDSTSMERETDFTSALTADVSGMRIGIPRDYLGEGLDGEVKEAVLRAAGELEKKGAALEEFDLSLVEYAIPAYYTIASAEASSNLERFDGIKYGYRATDYDGLHSMYKKTRSDGFGPEVKRRIMLGSFVLSSGYYDAYYLKALKVKALIKKAFDEAFGRFDCLLGPVAPTTAPQLGKSLTDPLRMYLGDIYTISVNLAGLPAVSLPCGVSSDGLPIGLQLIGDCFQEKKLIRAAYTYEQARGKFPLSPAWEGRNAKTADGTVNAGTDGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFP2</accession>
    <name>F7KFP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254572.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04671"/>
    <dbReference type="EnsemblBacteria" id="EGN34882">
        <property type="protein sequence ID" value="EGN34882"/>
        <property type="gene ID" value="HMPREF0994_04671"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5102"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="318" mass="35289" checksum="949E6D71C1BFBB79" modified="2011-09-21" version="1">MVKYLLRRFCEMILTLFLIATATFFLLEAVPGDPLSQRADKLQPQAKETLYKRYGLDKPVMERYAITMVNMAKGDFGESFVYAGQTIGKLVHDRLPVSARLGIQQMLLGVTIGLLLGILAATRRGTIADYMVVGLSVLLISVPHLIFGLLLQKVFAGNLRWFPTIGWPAGKDLWVGGWEYTFLPTLTGCFTYVATYARLLKTSMLDVINQDYVLTAESKGLSRAAVVRRHILRNSFIPVMTQLPMSVAMCITGSFFIESIFSIPGIGQYFVTAVNNQDLSIVLGETVLLAALYIVVLFITDILYVLVDPRIGMPGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFQ0</accession>
    <name>F7KFQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254580.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04679"/>
    <dbReference type="EnsemblBacteria" id="EGN34890">
        <property type="protein sequence ID" value="EGN34890"/>
        <property type="gene ID" value="HMPREF0994_04679"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5110"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364001" evidence="1">
        <location>
            <begin position="28"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="570" mass="62571" checksum="2270E47D8FCD257A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFW8</accession>
    <name>F7KFW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04747"/>
    <dbReference type="EnsemblBacteria" id="EGN34673">
        <property type="protein sequence ID" value="EGN34673"/>
        <property type="gene ID" value="HMPREF0994_04747"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3062701_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="53" mass="6347" checksum="F81CDD345919DCBF" modified="2011-09-21" version="1">MTLRDYLFFDCKPLKFTLQLTFLIFGDMILIKFGKSKKMPNFIKIIIMKNRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG11</accession>
    <name>F7KG11_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_04790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254691.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04790"/>
    <dbReference type="EnsemblBacteria" id="EGN34417">
        <property type="protein sequence ID" value="EGN34417"/>
        <property type="gene ID" value="HMPREF0994_04790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5232"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031875_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="535" mass="61349" checksum="99BC29D4AE7B382C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG56</accession>
    <name>F7KG56_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254736.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04835"/>
    <dbReference type="EnsemblBacteria" id="EGN34462">
        <property type="protein sequence ID" value="EGN34462"/>
        <property type="gene ID" value="HMPREF0994_04835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="238" mass="28616" checksum="B59903421E502E8B" modified="2011-09-21" version="1">MVRIALVDDDIEFHALFSKYIRNFFHKNNILHELRLYNCPETLRYDLKEGRQSDLYFLDIEMPEMNGFELAKFMRKEAPSSMLVFLTSHLEYAVEGYEVQAFGYIPKNLLSEKIEGTLERFLTEMRKKTRKAYVIEGGSRFERVEYEDIVYMYKDKKNTVFVLMDRQISFRKPLREVFDEVDSDCFMYIERGYVVNIEHIIRLVDKDLELRDGTTLHIGRTFVKKVKKTILHFWKDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGJ9</accession>
    <name>F7KGJ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254879.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04978"/>
    <dbReference type="EnsemblBacteria" id="EGN33773">
        <property type="protein sequence ID" value="EGN33773"/>
        <property type="gene ID" value="HMPREF0994_04978"/>
    </dbReference>
    <dbReference type="GeneID" id="29726635"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5437"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="473"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="872" mass="96923" checksum="83FE32328D318B0B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGK8</accession>
    <name>F7KGK8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="10">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycogen branching enzyme</fullName>
            <shortName evidence="10">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glgB</name>
        <name evidence="13" type="ORF">HMPREF0994_04987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254888.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04987"/>
    <dbReference type="EnsemblBacteria" id="EGN33782">
        <property type="protein sequence ID" value="EGN33782"/>
        <property type="gene ID" value="HMPREF0994_04987"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5448"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_9"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="176"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN33782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="640" mass="73818" checksum="F6762E0FE216992C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGM7</accession>
    <name>F7KGM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254907.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05006"/>
    <dbReference type="EnsemblBacteria" id="EGN33801">
        <property type="protein sequence ID" value="EGN33801"/>
        <property type="gene ID" value="HMPREF0994_05006"/>
    </dbReference>
    <dbReference type="GeneID" id="29726539"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363760" evidence="1">
        <location>
            <begin position="26"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="542" mass="60067" checksum="E150AB0ACF6C0BE6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGM9</accession>
    <name>F7KGM9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254909.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05008"/>
    <dbReference type="EnsemblBacteria" id="EGN33803">
        <property type="protein sequence ID" value="EGN33803"/>
        <property type="gene ID" value="HMPREF0994_05008"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5470"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="582" mass="68206" checksum="BE4F69E9BE1DA5FF" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGP3</accession>
    <name>F7KGP3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254923.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05022"/>
    <dbReference type="EnsemblBacteria" id="EGN33817">
        <property type="protein sequence ID" value="EGN33817"/>
        <property type="gene ID" value="HMPREF0994_05022"/>
    </dbReference>
    <dbReference type="GeneID" id="29726495"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5485"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="28731" checksum="C16063D31F54DF5A" modified="2011-09-21" version="1">MFANERRIQITEMLNRRSSVTVNELTDTFRVSLETIRRDLEYLEKQGALKRVHGGAVTVHKMQNYTSLSFRVSEHREEKRKLALASLPFIHEEDRIALDTGSTSFELASLLCERFSRLTIVTNSLEVFQILSGKEGFQTILTGGFYMPGEKTFYGHLALDMIKQLHVSKFFLAPSAVSLDFGISDHIHEMIAVQRALIAISDQIIVQADSSKFETCAALKVCDLNPRFLYFTDSGLPDEIAEAYRKAGLQITKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGP4</accession>
    <name>F7KGP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254924.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05023"/>
    <dbReference type="EnsemblBacteria" id="EGN33818">
        <property type="protein sequence ID" value="EGN33818"/>
        <property type="gene ID" value="HMPREF0994_05023"/>
    </dbReference>
    <dbReference type="GeneID" id="29726494"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5486"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078712_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="258" mass="28722" checksum="2299BDFCE79D443D" modified="2011-09-21" version="1">MNKKVLLILADGLRPDALAACGHPYGIRLTELGCCCLETETVYPSVTLPCHMSLFHSVDPSRHGILTNTYVPQVRPVNGLCEQLNAAGKTCAFFYNWEELRDLSRPSSLAYSYFVSGSVYTYEKANEMVTANALSFIREEKPDFAFVYLGLTDSAGHQYGWMGEEYLKACRQSLDEIQKLTESFMDEYTIIITADHGGHDRTHGSLEKEDMLIPLICIGPDFCPGSRFEQAGICDIAPTITRLSGTLPAREWEGKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH35</accession>
    <name>F7KH35_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255070.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05171"/>
    <dbReference type="EnsemblBacteria" id="EGN33204">
        <property type="protein sequence ID" value="EGN33204"/>
        <property type="gene ID" value="HMPREF0994_05171"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5651"/>
    <dbReference type="eggNOG" id="ENOG502Z8HY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053310_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16428">
        <property type="entry name" value="TcpC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024735">
        <property type="entry name" value="TcpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035628">
        <property type="entry name" value="TcpC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12642">
        <property type="entry name" value="TpcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="302" mass="34450" checksum="8EDEAA1A26F16E24" modified="2011-09-21" version="1">MIQIRKEENQKKQKEKKLKVYKVNTHKKTVIALWVLLAVSFLFAVYKNFTAIDIHTVHETKVIEETILDTHKIENFVKNFAEVYYSWEQSAASIDNRTNALKGYLTGELQALNVDTVRKDIPVSSALTDFQIWEITEEKEQHYQVTYTVEQRITEGESGKTVRSAYQVTVYVDGSGNLTIIQNPTITSVPVKSGYTPKAVQSDGTVDSITTEEINEFLTTFFKLYPTATAKELTYYVNEGVLKPVGKEYIFSELVNPVYNRNGNQVTASLAVKYLDNQTMTTQVSQFNLVLEKDGENWKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH72</accession>
    <name>F7KH72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255084.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05208"/>
    <dbReference type="EnsemblBacteria" id="EGN33241">
        <property type="protein sequence ID" value="EGN33241"/>
        <property type="gene ID" value="HMPREF0994_05208"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5686"/>
    <dbReference type="eggNOG" id="ENOG502Z9TP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1073002_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="29524" checksum="A8E813D3C03FAAF0" modified="2011-09-21" version="1">MGLDIYAGTLTRYYSHNWKTVVQQWAEENGYSFNRITPDGEPADKEEEMSPAEVQAAVENWRDQILSAISQPGQPPYAPWLENNEKPYYTDKPDWDAFGAMLLVAACRTYEEPVPSTVEKDWIFGEHPLVARLASDEERVWSLFRGATWWLPLSDSFLFQGSLPTDDTAAIATLGGLRKELEKLNQLAWQADEDTILGWADTEGYPVDGTVDSDGQYSKADIPEHTQYDTQSLAKFAFSMFWRAMRFAEEQQVPILLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH75</accession>
    <name>F7KH75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05211"/>
    <dbReference type="EnsemblBacteria" id="EGN33244">
        <property type="protein sequence ID" value="EGN33244"/>
        <property type="gene ID" value="HMPREF0994_05211"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5689"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163959_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="72" mass="7959" checksum="F87E17923DE20F8B" modified="2011-09-21" version="1">MSIAEEHTYIAIDLKSFYASVECLGLGLDPLDTNLVVADEIRTDKTICLAVTPSLKAYGISGRARLFEVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHC4</accession>
    <name>F7KHC4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4366 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002589132.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05263"/>
    <dbReference type="EnsemblBacteria" id="EGN33296">
        <property type="protein sequence ID" value="EGN33296"/>
        <property type="gene ID" value="HMPREF0994_05263"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5749"/>
    <dbReference type="eggNOG" id="ENOG502Z81G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091994_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025376">
        <property type="entry name" value="DUF4366"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14283">
        <property type="entry name" value="DUF4366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4366" evidence="2">
        <location>
            <begin position="56"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="26861" checksum="3915C688FD33FA3E" modified="2011-09-21" version="1">MRNKRLLRTLSALCLTLVLASGFTVPAFAQGAAPPPAEDTTNDSNVVVEETEKAPPLTPEGNAALVDDFGGNKQLITVTTKAGNYFYILIDRANEDKKTAVHFLNQVDEADLMALMEDGKPKEEPPAVCSCTKKCEAGAVNTACPVCVTDKSKCTGKAPEPPAETPEPEKEKPAGLNPAALILLLALLGGGGVFAYLKLVKNKPKTKGNDSLDDYDYGEEDSEEWETEDEEVLEDGFEGSDPNEERDRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHD3</accession>
    <name>F7KHD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33305.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05272"/>
    <dbReference type="EnsemblBacteria" id="EGN33305">
        <property type="protein sequence ID" value="EGN33305"/>
        <property type="gene ID" value="HMPREF0994_05272"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Zn_ribbon_recom" evidence="3">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4368" evidence="4">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33305.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="339" mass="39747" checksum="59865D5BA6A6AC23" modified="2013-09-18" version="2" fragment="single">RRLEEEKIPCPTWWNRERGLRNTRTKWEKKDPENGRYMWDFSVIKDLLMNPVYTGAIASQKKDYRFKIGTIGEKKPEDWIVVEGQHEPLIDRMSFDIVQNKLKSRQRPGQTNEISLFAGLIKCGECGKSLTIRCTNTKHPQQIYSCKTYNAFGKNHCTQHRIDYDTLYSHVLRKIRECARAALMDGEAVADRLTNTCEAEQREQREAMERSLTRDEERIEVLDKMVMRLYEDMIAGRISEQNFNTMLEKTQTEQTELKTKVSEGRKRLSDEVQLANDAKQWVEAIQEYANITELDAATLNRLIKEIVVHERIDEDKTRHISIEIHFNLKPIPEVEQVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHG1</accession>
    <name>F7KHG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255133.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33025">
        <property type="protein sequence ID" value="EGN33025"/>
        <property type="gene ID" value="HMPREF0994_05290"/>
    </dbReference>
    <dbReference type="GeneID" id="29727781"/>
    <dbReference type="eggNOG" id="ENOG502ZARC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_581004_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF" evidence="1">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="MABP" evidence="2">
        <location>
            <begin position="305"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="54745" checksum="2A3401966E26827C" modified="2011-09-21" version="1">MSNIDLLKLQSLLDDHRHYLLQGYNVVSNPYLRTEDIQMSNTILDKDKLNEKFPGNSFYNYVSGNETGSISETYAGNTLYEMENSFGTKNTIAYNSVALNASLSADYQTGNSILDNNIFLKQYQAHVLGHIYSRGDVSDLRECLDAHFREDLENMEPRKLFFKYGTHLIRDFSVGGCIMLDMRYHNHMHKTVQQVSADAAAAYSGLSLDSSTSAYKNAVSFYQNVSVRIRSVGGNSFSAFSVSDFNSQSKAWMDSLADKAVPFRINRNGSLPIWELTSNAARAKTLEKEFYLYNIDVLDEVKANIPFITDLRVEIRDKDNIRSVCPENWYVAQMNPGTLSAYDIDLNKGSGGKYIYLLYRFGTNQKDRITDIKILMGRNTTLGGYTRIDADLNTGSGGEYIYLAYKKEDNKEKDGIYGLGTTEQSSFTDNYWRMAKDQNNNLADLNKGAGGLFIYLLTYREKYLDEIEREKRELQALTDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHG6</accession>
    <name>F7KHG6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255138.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05295"/>
    <dbReference type="EnsemblBacteria" id="EGN33030">
        <property type="protein sequence ID" value="EGN33030"/>
        <property type="gene ID" value="HMPREF0994_05295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5781"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060270_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="384" mass="45242" checksum="C34ED6FDB074B360" modified="2011-09-21" version="1">MKYKENWEETKQKWEKYWKRENTGRPLMSIIAEKPEAMDAERAARLKSVDVEDKYMDPERIVERFRYFCETHDFLAESFPNLSVDFGPGSMAGYLGSEIVFDMKTVWFREFVEDWLDYPDLAFDPENKWFQKHMEVFRRVCELSDGDFYVGIPDIMENLDVLVSMRGAQDTIFDMMDEPEELLRRVNQVQDLYFTYYDAFYDLAKQVENGKESSCYTVFQIWGEGKIAKLQCDFSAMISPDQFREFVQEALRGQAKQLNHSLYHLDGPDAIRHLDAIMEIEEIDALQWTSGDYGPDGTFEEWYPIYDKAVAAGKALWVKVYSGETEEWLERLDKLVARYGSSALFLYFSPMSRENADKILSHAEKHWSDVEGSFTRECRKRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHI2</accession>
    <name>F7KHI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33046.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05311"/>
    <dbReference type="EnsemblBacteria" id="EGN33046">
        <property type="protein sequence ID" value="EGN33046"/>
        <property type="gene ID" value="HMPREF0994_05311"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1624974_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33046.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="163" mass="16788" checksum="37C0D9A93B30A1CE" modified="2013-09-18" version="2">MGKKGGEDGEEEGGKVKGHGFVGGRFHGGHLEYGGQECPVGGIVGGNEGGKGEFSFCQLAACGKESGVMEELKTVGAQEHVADLSGPVDAGGMEFVRVYEHDIAFLKREAVAVDFQAAGDGGENDFQFFMPVYGDVGAGFGNLEIINVEGDISHGSGAGFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHQ3</accession>
    <name>F7KHQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255228.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05385"/>
    <dbReference type="EnsemblBacteria" id="EGN32826">
        <property type="protein sequence ID" value="EGN32826"/>
        <property type="gene ID" value="HMPREF0994_05385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5887"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="33352" checksum="A06C44B4137E4D7D" modified="2011-09-21" version="1">MGDYIISCCSTADLTEEHFRERDISYICFHYELDGVQYADDLGKSMGFEEFYKKMTLGADTKTSQVNLEEFREYFEPFLKEGKDILHLCLSSGISGVLNSALAAKQELEELYPDRKIYVVDSLGASSGYGLIMDKLADLRDGGMGIDELHDWAEKNKLRMNHWFFSTDLTFYIKGGRISKASGFIGTVLAICPLLNMDDQGRLIPRFKIRTKRKVIQAIVEKMEEYADGGLEYSDKCYISQSACYEDARAVADLIEERFPKLKGKVVINYVGTTIGSHTGPGTVALFFWGKERTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHZ8</accession>
    <name>F7KHZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002571047.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05500"/>
    <dbReference type="EnsemblBacteria" id="EGN32941">
        <property type="protein sequence ID" value="EGN32941"/>
        <property type="gene ID" value="HMPREF0994_05500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6014"/>
    <dbReference type="eggNOG" id="COG2232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="118"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="422" mass="47418" checksum="3914DF01E47239A2" modified="2011-09-21" version="1">MAHLLMIESWVGASGNLLPPLLRELGHSYTFVTRKASHYQNPMSSEKHAVFRYADDVVETETNDLQQLIESVRHVRFDGVITVCDYYIETVCEVAKAYNVPCPFSANVKTARQKHLMRQAVDRAGLSNPKYMLAYNWEEVEKAAQEIGYPLVLKPVDLASSAFVKLIQTSNDLQQAYRDLENFPLNFRDQERERAFLIEEYICGEEVSVETVSNNGEITVVGITDKSVTGSPYFIENGHMFPAKLDEDVKEEIGDYVRNVLLATGYDHGIAHTEIKLTKDGPKVVEINPRTAGNYIVELIEYVTGVNMLKAFVSLALGQQPSVTVSDTNVSSAAIMFIVPDCGGKIRQIKGADTLREDSNIIRYRIEDCVGKSIEKPIDNACYLGHVITRDCDGYGARMFAETALRRLEIEFEETERVHEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI29</accession>
    <name>F7KI29_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MobC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255338.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05531"/>
    <dbReference type="EnsemblBacteria" id="EGN32972">
        <property type="protein sequence ID" value="EGN32972"/>
        <property type="gene ID" value="HMPREF0994_05531"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6044"/>
    <dbReference type="eggNOG" id="ENOG502ZBKZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096411_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="131" mass="14595" checksum="25C0FE567D5CF042" modified="2011-09-21" version="1">MKRYNMPHRSRVVKTRLTDEEYADFTARLAPYGMSQSEFIRQAITRATIRPIVTVSPVNDELLAAVGKLTAEYGRIGGNLNQIARYLNEYGVPYNALSGEVRAAISDLAALKFEVLQKVGEAVGNIQTYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIB2</accession>
    <name>F7KIB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255398.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05591"/>
    <dbReference type="EnsemblBacteria" id="EGN32416">
        <property type="protein sequence ID" value="EGN32416"/>
        <property type="gene ID" value="HMPREF0994_05591"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="32030" checksum="4BAD5051A6A29114" modified="2011-09-21" version="1">MSNRTFSPANRKKNYMGRHHVGAYIVLVIGAIIMILPFLWMVLTSFKTYSESIAVPIQWLPSRLNFDAYTETISKLNLLTYYKNTIIVTFFSVIGQVSICAIAAYAFARIRFPGRDVIFLLVLASMLIPGQMTLIPKYIMCADLGLINRLAGIVIPNLFNAYGVFFLRQFFMTLPRSLEESARLDGCSYFRIFWNIMLPLCKSGLAAFAILTLMGSWNDLLWPLIITSADSQRVLAVGIACLQGEHMSDYPTMMAASMLATLPLIVAFIIGQKWFIASIATSGIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIR3</accession>
    <name>F7KIR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006859298.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05752"/>
    <dbReference type="EnsemblBacteria" id="EGN32241">
        <property type="protein sequence ID" value="EGN32241"/>
        <property type="gene ID" value="HMPREF0994_05752"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6289"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002880_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041895">
        <property type="entry name" value="ArdA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041893">
        <property type="entry name" value="ArdA_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013610">
        <property type="entry name" value="ArdC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025465">
        <property type="entry name" value="DUF4316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040512">
        <property type="entry name" value="LPD15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025923">
        <property type="entry name" value="YodL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08401">
        <property type="entry name" value="ArdcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14195">
        <property type="entry name" value="DUF4316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18828">
        <property type="entry name" value="LPD15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14191">
        <property type="entry name" value="YodL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD15" evidence="5">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ArdcN" evidence="3">
        <location>
            <begin position="421"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M78" evidence="2">
        <location>
            <begin position="582"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4316" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1108" mass="125439" checksum="215CEE92C9A00A4A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJB4</accession>
    <name>F7KJB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05956"/>
    <dbReference type="EnsemblBacteria" id="EGN31584">
        <property type="protein sequence ID" value="EGN31584"/>
        <property type="gene ID" value="HMPREF0994_05956"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2990921_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="57" mass="6667" checksum="E22918702EAF2F21" modified="2011-09-21" version="1">MREEQAQMTFEVCIEECRNYTWQGKLTAEEKVLEFKSETELLLAMDTLMYGEGEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJE1</accession>
    <name>F7KJE1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-sigma F factor</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Stage II sporulation protein AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIAB</name>
        <name evidence="5" type="ORF">HMPREF0994_05970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anti-sigma-factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255746.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05970"/>
    <dbReference type="EnsemblBacteria" id="EGN31324">
        <property type="protein sequence ID" value="EGN31324"/>
        <property type="gene ID" value="HMPREF0994_05970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6534"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_11_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016989">
        <property type="term" value="F:sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042174">
        <property type="term" value="P:negative regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00637">
        <property type="entry name" value="Anti_sigma_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010194">
        <property type="entry name" value="Anti-sigma_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01925">
        <property type="entry name" value="spIIAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="35"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="153" mass="16792" checksum="52DEEBC5E439782C" modified="2011-09-21" version="1">MSNEMKLEFDAVSENEGFARVAVAAFVTPLDPTLQEVADVKTAVSEAVTNAIIHGYADWGSLGQGPGKVVIRCCLNEDVLHIEVEDKGRGIEDVEKAMEPLYTTRPDMDRSGMGFAFMEAFMDDLDVESEPGKGTLVKMEKKLGTLSWTEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJI8</accession>
    <name>F7KJI8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06022"/>
    <dbReference type="EnsemblBacteria" id="EGN31376">
        <property type="protein sequence ID" value="EGN31376"/>
        <property type="gene ID" value="HMPREF0994_06022"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="336"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN31376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="632" mass="73209" checksum="5712D8045F1810D4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJJ9</accession>
    <name>F7KJJ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06033"/>
    <dbReference type="EnsemblBacteria" id="EGN31387">
        <property type="protein sequence ID" value="EGN31387"/>
        <property type="gene ID" value="HMPREF0994_06033"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077618_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="181" mass="21102" checksum="08AC2CFF09406AA1" modified="2011-09-21" version="1">MGKPEQSITTQIKDTEKQKKIRRAVFLVYLAVTIKLIIFKYPWEHLKEIMDTWEKGIILEGLETANFTLFKTVRMYIIYHDRLNSFENLAGNVGIFVPFGIFLPWTDPIYRSWWRVLCNAFLFVTGIEVFQLFSAFGAFDVDDILLNCFGAMLGYLMFRLLERKKASFRAPAGPREKEGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJZ1</accession>
    <name>F7KJZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255956.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN30673">
        <property type="protein sequence ID" value="EGN30673"/>
        <property type="gene ID" value="HMPREF0994_06180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6768"/>
    <dbReference type="eggNOG" id="ENOG503369K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139025_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="14434" checksum="A1D19DC3CB24E272" modified="2011-09-21" version="1">MWNVIICDGDEPERELLMGFVRQYFEEKKKDAQVAGCMDWPELEGMVKQSLPDVVIVAQNSVDGLNTITSARLLSRKIIWFSDLDFGVQAYRLCVPYFSTKPVTYQKMEQALTRFFEVSPWLGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK47</accession>
    <name>F7KK47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06150"/>
    <dbReference type="EnsemblBacteria" id="EGN30643">
        <property type="protein sequence ID" value="EGN30643"/>
        <property type="gene ID" value="HMPREF0994_06150"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6736"/>
    <dbReference type="eggNOG" id="COG1078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051349_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="348" mass="40009" checksum="34A2EF18D79764A7" modified="2011-09-21" version="1">MTEPISEEMSPLWDIYNDGFPDFLAELLEAEELQRLKKVGMHCGCEYSSFPLFRFSSPYTRWIHSVGAGLIVWHFTFDVKQSIAGLLHDIATPVFAHVVDFMKGDHLKQESTEEYTRKLIEESEGIQKVLHKYGLSTEDVADYHRYPIADNDSPGLSADRLEYTLGNFYCREKKSPGEIRRIYRNLTTVLNEEGIPELAFTSSEEALTFTLGSLDNSRMFTADEDRFCMQYLADLLRKAVEWGILSESDLYTTEEQVLDKLLQDERAAGLWEEYTRFSQIRSSAEPVEGIYCVNVPSKLRYIDPLVVQEGIPVRISKICTKAAEAVREYLHTDFDRWISVSGEQECKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKX9</accession>
    <name>F7KKX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06508"/>
    <dbReference type="EnsemblBacteria" id="EGN47519">
        <property type="protein sequence ID" value="EGN47519"/>
        <property type="gene ID" value="HMPREF0994_06508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356709" evidence="5">
        <location>
            <begin position="27"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN47519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="443" mass="47503" checksum="AC657F9A52DE28CD" modified="2011-09-21" version="1">MKKKAVSVLLAISMLAAGMMGCGKQAATDSTGAAAETPAAQASESKEAADTGASSGAVEIEFVNQKREAADTFQAVIDKFSEQNPDIKVTLNTTPDGSGVLMTRASSDTLPDILMHWPTDAQFVQFANEGLLADLSGKDYTGNIVQSYIEDLKMEDGGIYCLPISLNFMGVYYNVDKFTEAGFSVPQTWDELIALCDKIVEKGEVPFLLPNKDSWTVSQLWDNIGGKDRGGYADFYAGLDDGSQSYAADAIANDSMEKMVLLTEKYSQGDTLSLGYDQAINDFATGAAYMFIQGSWALPSIQAANPDANVEMFPMPNNSGDMKQPVGVDCAICVSAKAAADPAKSEAVDKFMAYLFSTEAGQMYSDMDHSPSAITGVTADIPQDKLVLDLIDKAGVLDLAVPPTGFEDTKRSEIQNVFMGTSVPDFLSQLDEDWKTAREAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKY1</accession>
    <name>F7KKY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256272.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06510"/>
    <dbReference type="EnsemblBacteria" id="EGN47521">
        <property type="protein sequence ID" value="EGN47521"/>
        <property type="gene ID" value="HMPREF0994_06510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7128"/>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046240_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN47521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="368" mass="39748" checksum="8041EEF3676FC4EF" modified="2011-09-21" version="1">MEKSKVYFTTMKTSFSENLPQKLERLIKTAGIGNIDFTDKYAAIKMHFGEPGNLAFLRPNYAAVVVKVIKELGGKPFLTDCNTLYVGGRKNALDHIDAAYQNGFSPFSTGCHVIIADGLKGTDEELVPVEGGEYVKEAKIGRAIMDADVFITLSHFKGHEATGFGGALKNIGMGCGSRAGKMEMHNAGKPYVEQENCIGCGRCIKICAHDAPSITNGKASIDHKKCVGCGRCIGVCPKDAVCTPGDESNDILNRKIAEYSKAVVSGRPHFHISLVVDVSPNCDCHSENDIPIVPDVGMFASFDPVALDVACADAVNKQPVIDGSQLDRMPHVHHDHFIDSAPDTNWHSCIEHGVKIGLGSDQYELIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL18</accession>
    <name>F7KL18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256309.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06547"/>
    <dbReference type="EnsemblBacteria" id="EGN47266">
        <property type="protein sequence ID" value="EGN47266"/>
        <property type="gene ID" value="HMPREF0994_06547"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="379"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="475" mass="54697" checksum="CB081773E0BD5525" modified="2011-09-21" version="1">MFILIADDEKMIRLSLQSMLEELYPNEHMYIHASNGQAAIAQVQKLPPDIAFLDIRMPLMNGLEALETCRKLSPSTKWIILSGYADFEYAQKAITLSAYSYLLKPVDLATLKQVVDDIVVLKNQEKEHDNKLFTLDVIRSFNMADQLGSNETAFLPYGTNPYVIYQIYIDEQEKERQHMLKHDLFRSIDDFCRRNLFLFYHAVFFNTNGELCVICSVKDPSHLTFFINSQIRSYPHDMISVFTAAAGSLSEIYEESRRISRLSEIRLVYDCRSAADIRSLTEIPILHDLLSFCEQIDLFIQNALVGSRETIRQLSAAFIQNQKMKKIFDNICLSTLYLYLEDVLAHSFTADDFAGFVKELQAAASELSHIEPLRNFDITVIKDFVHQNYAKDVSIAYVSEYFNLSPTYFSKLFHEKTGQKYIDFVTEVRIENAKKLIRSNANISVKQTAEAVGYTSVRHFSKIFQKYTGVLPSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL55</accession>
    <name>F7KL55_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256350.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06588"/>
    <dbReference type="EnsemblBacteria" id="EGN47307">
        <property type="protein sequence ID" value="EGN47307"/>
        <property type="gene ID" value="HMPREF0994_06588"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7212"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="416"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="520" mass="60972" checksum="218F578308E9FDC0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLB5</accession>
    <name>F7KLB5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256397.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06644"/>
    <dbReference type="EnsemblBacteria" id="EGN46568">
        <property type="protein sequence ID" value="EGN46568"/>
        <property type="gene ID" value="HMPREF0994_06644"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7265"/>
    <dbReference type="eggNOG" id="COG1625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037396_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="449" mass="51628" checksum="E212A4712F3E6454" modified="2011-09-21" version="1">MKRKGHLIQAVSEDGIACEMGIEPGDRLLEINGETVEDVFDYQYMIEEEYVEVLVAKPSGEEWLLEIDKDYEEDLGITFENGLMDEYRSCSNKCIFCFIDQMPKGMRETLYFKDDDSRLSFLQGNYVTLTNMSERDVERIIKYHLSPINISFQTTNPELRCRMLHNRFAGEALKKAELFYEAGIQMNGQIVLCKGFNDGEELDRSIRDLTRYLPHLQSVSVVPVGLSKFREGLEPLEPFTREDAKYVLGQIHGWQEKIFPEYGLHFVHASDEWYILAGEEMPPEETYDGYLQLENGVGMIRLMLEEFEDALRQLEEPGALEGRILEGTYSSVTGKIAYPYIRRMADRIMERFPEISIHVYPVRNDFFGEKITVTGLLTGQDIIAQLKGQELGEILYLPENILRSGEQVLLDDITVRDLSGALQVKTDIVKSSGYDFVNAFIRRMDGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLD5</accession>
    <name>F7KLD5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ORF">HMPREF0994_06664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256417.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06664"/>
    <dbReference type="EnsemblBacteria" id="EGN46588">
        <property type="protein sequence ID" value="EGN46588"/>
        <property type="gene ID" value="HMPREF0994_06664"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7287"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="81" mass="9279" checksum="2AFBB5A71D5B34F6" modified="2011-09-21" version="1">MAVKIRLRRMGQKKAPFYRIIVADSRSPRDGRFIEEIGTYDPNKNPSEFKVNEELAKKWLNNGAQPTEVVSKIFKAAGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLH8</accession>
    <name>F7KLH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPr family phosphocarrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256469.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06716"/>
    <dbReference type="EnsemblBacteria" id="EGN46640">
        <property type="protein sequence ID" value="EGN46640"/>
        <property type="gene ID" value="HMPREF0994_06716"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7345"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="85" mass="9210" checksum="523B81D7F2067886" modified="2011-09-21" version="1">MKEFKYTITDELGIHARPAGLLVKKAAEFASTVSVDNGTKKGDAKKIMSLMMMAVKQGQTVTFTIEGPDEDAAAQALEAFMKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLQ6</accession>
    <name>F7KLQ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256538.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06785"/>
    <dbReference type="EnsemblBacteria" id="EGN46377">
        <property type="protein sequence ID" value="EGN46377"/>
        <property type="gene ID" value="HMPREF0994_06785"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN46377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="561" mass="65502" checksum="5690B2E892B02201" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLR6</accession>
    <name>F7KLR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256548.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06795"/>
    <dbReference type="EnsemblBacteria" id="EGN46387">
        <property type="protein sequence ID" value="EGN46387"/>
        <property type="gene ID" value="HMPREF0994_06795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="335"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="430" mass="48712" checksum="8C419E0533AD1542" modified="2011-09-21" version="1">MSTIRCINISLELFGVFLSLILILSLLLYRIEKDALNSCFLKVLIMNTLLLGSDAAAWGLKGRPGTAAWYGVHTANFLVYVLGYFLLAAFTDYLVNYIAAKGPVSRKPVILMRGLALTAVLLVIISQFNHMYYLIDKNNVYHRQGLFWLSQMWGIFCIVLNAGLLFHHRKKLSDKDILVFTVYIALPLLAMLIQIFVYGIALLYLSTTITILCIYLGIQEEEANKRREKERELTQGRIAVMLSQIQPHFLYNSLLGIKQLCDTEPRKASDALVHFSYFLRGNLDSLSDIRLIPFSKEINHVQDYLYLEKMRFEERLNIEWDITFDDFFLPPLTLQPLVENAVRYGITEQEEGGTIWIQSKLTSDAVIITIIDDGCGFDTAETKADGHTHIGITNVRQRLESQCHASLAIISIPGVGTKAEIIIPLKEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRR8</accession>
    <name>S2KRR8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-fucose isomerase</fullName>
            <shortName evidence="7">FucIase</shortName>
            <ecNumber evidence="7">5.3.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-deoxy-L-galactose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fucI</name>
        <name evidence="11" type="ORF">HMPREF0994_07194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts the aldose L-fucose into the corresponding ketose L-fuculose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-fucose = L-fuculose</text>
            <dbReference type="Rhea" id="RHEA:17233"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:17617"/>
            <dbReference type="EC" id="5.3.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the L-fucose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.25" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360130.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07194"/>
    <dbReference type="EnsemblBacteria" id="EPC05139">
        <property type="protein sequence ID" value="EPC05139"/>
        <property type="gene ID" value="HMPREF0994_07194"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033326_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00563">
        <property type="reaction ID" value="UER00624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042355">
        <property type="term" value="P:L-fucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01254">
        <property type="entry name" value="Fucose_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005763">
        <property type="entry name" value="Fucose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01089">
        <property type="entry name" value="fucI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="9">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="10">
        <location>
            <begin position="181"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_C" evidence="8">
        <location>
            <begin position="397"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EPC05139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="597" mass="66248" checksum="036867FBB3F3ABBB" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRT2</accession>
    <name>S2KRT2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_07209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360157.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07209"/>
    <dbReference type="EnsemblBacteria" id="EPC05154">
        <property type="protein sequence ID" value="EPC05154"/>
        <property type="gene ID" value="HMPREF0994_07209"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010808">
        <property type="entry name" value="CheA_P2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035891">
        <property type="entry name" value="CheY-binding_CheA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07194">
        <property type="entry name" value="P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55052">
        <property type="entry name" value="SSF55052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="11">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="290"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="10">
        <location>
            <begin position="536"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EPC05154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="693" mass="78762" checksum="71DFF8A585123DAA" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRX3</accession>
    <name>S2KRX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EPC05032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360342.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05032">
        <property type="protein sequence ID" value="EPC05032"/>
        <property type="gene ID" value="HMPREF0994_07318"/>
    </dbReference>
    <dbReference type="GeneID" id="29729907"/>
    <dbReference type="HOGENOM" id="CLU_1852632_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="138" mass="15653" checksum="F4318F106A859AF9" modified="2013-09-18" version="1">MKFGELPIAQGMLPLHAEKTSFPESGSLLIGQINLIQIGNRTAIGKKKGIQRTAFLRKIFFIAFQKTVKFVQRKAAFQENDFIAVLIKVFKGMVSLICYFEKICEAVAGILRIFTEFFVNHYLVALCIQIHLLDFPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRZ3</accession>
    <name>S2KRZ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_07156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07156"/>
    <dbReference type="EnsemblBacteria" id="EPC05209">
        <property type="protein sequence ID" value="EPC05209"/>
        <property type="gene ID" value="HMPREF0994_07156"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="246" mass="27162" checksum="A22E5ABB833FBE9E" modified="2013-09-18" version="1">MRIHLNHLSMTYPTGKQALKDINLTLESPSLIGLVGPNGAGKSTLMKLLVAGLLPTGGDIAIDDKPLTKCEKELKKKLGYLPQDFGLYDELTIWEFLDYMAALKGIRNSRPVIEEAILATGLEEKKKARIKTLSGGQRQRVGIAQALLGEPEFLIFDEPTVGLDPEERIRFRNFFSQTAQDKLVLLSTHIIEDIQSVCDRLIVIDHGEILFIGKPEELILQARGHVGVLLEHNGDKKSLTCVSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS55</accession>
    <name>S2KS55_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07108"/>
    <dbReference type="EnsemblBacteria" id="EPC05259">
        <property type="protein sequence ID" value="EPC05259"/>
        <property type="gene ID" value="HMPREF0994_07108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061778_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="35213" checksum="CB9DAFC1BBEC3061" modified="2013-09-18" version="1">MKVDVIIPTYKPDKGFPEMIKRLEKQTLKPNRIIIMNTEEKYFEKLLYGTDFAREHPLVEVHHLSKREFNHGGTRHLGALHSSGDIFVCMTQDALPADNRLLEELAAPFLSDDRIAVSYARQLPEKDSGEIERFTRAYNYPEESCVKGKEQLPEMGIKTYFCSNVCAAYKKNIYQELGGFVRHTIFNEDMIYAAGAVQAGWKIAYAAGARVYHSHNYSCREQFRRNFDNGVSQAQHADIFSGVPSESEGMKLVKQTASHLFAVHKPWLVIKLIAASGAKYMGFWLGKHYKSLPARFVKVCSMNKDYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS93</accession>
    <name>S2KS93_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06992"/>
    <dbReference type="EnsemblBacteria" id="EPC05324">
        <property type="protein sequence ID" value="EPC05324"/>
        <property type="gene ID" value="HMPREF0994_06992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053686_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="151"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="342" mass="39896" checksum="82388EF6FD54EDBB" modified="2013-09-18" version="1">MSGAGLNMPKSSNQKLKLLYLLRILQKETDEEHYLNSQQLIERLEKYDISAERKSIYDDIARLTDFGYDIIHVKNKSGSGYYMGSREFELAELKLLVDVVQASRFITLRKSRELINKLEQFVSGKEAQQLQRQVYVAGRVKTDNESIYYNVDFIHRAIQENRQISFQYMEWTLDKKLVPRKGGARYVISPWALSWNDENYYLIGYDKEADLMKHYRVDKMGSIELTREERQGSSVFENFDIAVYTNKTFGMYGGREEIVSLVFADQLIGVVLDRFGRETDIRRLQEGTFRVRVKVAVSGQFFGWLTGLGTQVRLAGPENVVEEYRNYLKKIYDRYEEGCSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWI5</accession>
    <name>S2KWI5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359840.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07033"/>
    <dbReference type="EnsemblBacteria" id="EPC05365">
        <property type="protein sequence ID" value="EPC05365"/>
        <property type="gene ID" value="HMPREF0994_07033"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="6">
        <location>
            <begin position="143"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="544"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="692" mass="78455" checksum="632795FFF991038F" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>S2LK36</accession>
    <name>S2LK36_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">nnrD</name>
        <name evidence="15" type="synonym">nnrE</name>
        <name evidence="18" type="ORF">HMPREF0994_06961</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06961"/>
    <dbReference type="EnsemblBacteria" id="EPC05293">
        <property type="protein sequence ID" value="EPC05293"/>
        <property type="gene ID" value="HMPREF0994_06961"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="139"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="432"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EPC05293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="523" mass="56142" checksum="EA8B1AA3D8396214" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2E4</accession>
    <name>F7K2E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SrtB family sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48256.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00023"/>
    <dbReference type="EnsemblBacteria" id="EGN48256">
        <property type="protein sequence ID" value="EGN48256"/>
        <property type="gene ID" value="HMPREF0994_00023"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005033_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05826">
        <property type="entry name" value="Sortase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009835">
        <property type="entry name" value="SrtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03064">
        <property type="entry name" value="sortase_srtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363455" evidence="4">
        <location>
            <begin position="36"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1337"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1371"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="5">
        <location>
            <begin position="101"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="6">
        <location>
            <begin position="439"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="6">
        <location>
            <begin position="558"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="6">
        <location>
            <begin position="656"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="6">
        <location>
            <begin position="776"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="6">
        <location>
            <begin position="1012"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="6">
        <location>
            <begin position="1124"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN48256.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1640" mass="179098" checksum="E6A88D138F20BC73" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2I0</accession>
    <name>F7K2I0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_00059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250008.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00059"/>
    <dbReference type="EnsemblBacteria" id="EGN48292">
        <property type="protein sequence ID" value="EGN48292"/>
        <property type="gene ID" value="HMPREF0994_00059"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.63"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="12">
        <location>
            <begin position="177"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="271"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN48292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="457" mass="50938" checksum="7A3314CDC48F71D1" modified="2011-09-21" version="1">MKTESGINTRALVLDILLEMEKGQEYGSLLLKNVLDKYDYLESRDKAFIKRLTEGVTERRIQLDYVLGRFSKTPPAKCKPLIRNLLRMGAYQILFMDNVPDSAACNEAVKLAEKRHFQQLKGFVNGVLRSLSREKEKLVWPDKEKEPVLWLSVMYSMPEWIVKMWLADYGPETTEKILAGLLEPRPVTIRLAERLTEEERQELLARLEECGASPAAHPYLTYAYMLQKSDGVASLPGFSRGMFAVQDVSSMLVTECALDAAQKTDFLLDICAAPGGKAVHAAERLAGRGRVEARDISESKTGLILENARRMGLSNLEIKVWDATVPDEKMKGAADVVLADLPCSGLGVIGRKADIKYRVTPESLQEVAALQRRILTNAAEYVKPGGTLVYSTCTINKEENERQAAWFADNFPFSLRSLDGGLPEALKEKESKAGMCQLLPGIHKTDGFFIAAFVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2I9</accession>
    <name>F7K2I9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250017.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00068"/>
    <dbReference type="EnsemblBacteria" id="EGN48301">
        <property type="protein sequence ID" value="EGN48301"/>
        <property type="gene ID" value="HMPREF0994_00068"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VRS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098225_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025671">
        <property type="entry name" value="HXXEE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13787">
        <property type="entry name" value="HXXEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="230" mass="26575" checksum="9A98B0DAA92943F4" modified="2011-09-21" version="1">MKFWRRYWYLIGGILFVFLAFFMGLWGCSNLPRIQTILIFSWMAMLVHQTEEYAFPGGMPSITNMAAFREKEAPYKYPFHAQQCFICNVFLCYTFYILAICFPDVIWLGASQVLCVLVQLGAHALLINFSLKDIYNPGLGSTLFLQAPVAIYYIWYVVTRLPEKAGQLWIGIPGAFAAMIICFIAPVFLMKNRKNNYPFAEEEMYGYKKDKVLEIYHDSKPSILQKVGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2M9</accession>
    <name>F7K2M9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00108"/>
    <dbReference type="EnsemblBacteria" id="EGN42725">
        <property type="protein sequence ID" value="EGN42725"/>
        <property type="gene ID" value="HMPREF0994_00108"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.115"/>
    <dbReference type="eggNOG" id="COG5632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047675_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="132"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="32883" checksum="B00DF4858B6566BD" modified="2011-09-21" version="1">MAKRGVRTEAGRRYYPDGSYYSGRNAGAAARELEYIDITLRENPPKRKRSREEILARRKKRRRQRRIAQMLMAGCVLTMGIMLGFLLWKIIGFVQDRGVFNQVMDEERKEIIRENDTIKPVITEDFLTVNPYSRPAEPLDGVKNIFVHYTANKNTSARQNRSYFENLGITGETSASAHFIIGYDGEIIQCLPLDEIGYAVKTRNYDSISIECCYRDDSGKFTDATYQSLLQLTAWLLKEYKLAPNDVLRHYDVGGKKCPLYFVEHEDSWEQFRQDLTDYILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2R7</accession>
    <name>F7K2R7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42763.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00146"/>
    <dbReference type="EnsemblBacteria" id="EGN42763">
        <property type="protein sequence ID" value="EGN42763"/>
        <property type="gene ID" value="HMPREF0994_00146"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TVR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346956_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021359">
        <property type="entry name" value="DUF2812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11193">
        <property type="entry name" value="DUF2812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42763.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="170" mass="20350" checksum="0D1EA4ECC52A649D" modified="2013-09-18" version="2">MAWDYDKEEEHLDEMSEKGWQLKKGGCFFSVYTRQPGVVYRNRIDYNPDAVNSPEEKRRYLELFEEQGWEYVGNTYNGWIYFKKKYVPGTPEEEYEIYTDAESLQSLLDRWKRLGILLSVLLLVLTAIYTVMVFGGRYYNIIFVAFYVVLLVWIQWGMRRMRKKVTGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2V1</accession>
    <name>F7K2V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250129.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00180"/>
    <dbReference type="EnsemblBacteria" id="EGN40737">
        <property type="protein sequence ID" value="EGN40737"/>
        <property type="gene ID" value="HMPREF0994_00180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.192"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="347" mass="39139" checksum="89342B1DC53141F8" modified="2011-09-21" version="1">MNAMERVVTALQHKEPDRVPVYPILSGVSRKLVDADYKTWSTNADVCSRALLKAREKYDQDCIVSLIDLSVECDAWGQELIFPENEAAHPNYQNSLIQDIDEYSKIKKADYRNSERMMMHIETCKKLVKEANGEFPVIAFVFGPLGVLSMLRNQQDMYMDLYDDPDAVKEAAGEITETLKDYCRALMATGINGLMFDTLFSSGSIMSKEMWLDMEGPFVRELAEVTREAGGLVMIHNCGQRIYFDAQISMMHPDAISFLYPPDDCADFKECKKKYGDKVTLIGCVTPASAVLGTDEEWDEECRNCMDDMMEGGGFILATGCEYPANASFDRAERMVNLAKTYGRYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Z4</accession>
    <name>F7K2Z4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose_iso_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250172.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00223"/>
    <dbReference type="EnsemblBacteria" id="EGN37862">
        <property type="protein sequence ID" value="EGN37862"/>
        <property type="gene ID" value="HMPREF0994_00223"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.243"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045643_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_C" evidence="2">
        <location>
            <begin position="349"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="492" mass="54561" checksum="3AF4406A1145E0CB" modified="2011-09-21" version="1">MNNMPKEKIAIVAVSRDCFPMDLSVSRRKAVVAAYKEKYGDGLYECPVCIENEIDMRKALADVKEAGCNAIVVYLGNFGPETPETLLIKEFDGPAMVVAAAEETGDNLVSGRGDAYCGVLNASYNLKLRNLKAYLPEYPVGTASECADMIAEFAPIARAVVGLKNLKIISFGPRPKDFMACNAPIKQLFNLGVEIEENSELDLFEAFNNHAGDERIPEVVKDMEEELGTGNKKPEILSRLAQYELTLLDWIEEHKGSREFVAVAGKCWPAFQTQFGCVPCYVNSRLTKRGIPVSCEVDIYGALSEFIGTVVSNDVVTLLDINNTVPADMFESDIKGKYNYTQKDTFMGFHCGNTASSKLSFCEMKYQFIMARSLPEEVTQGTLEGDIIPGDITFYRLQSTADSKLRAYIAQGEVLPVATRSFGGIGVFAIPEMGRFYRHVLVEKNYPHHGAVAFGHFGKTLYEVFKYIGVEMDEINFNQPKGMMYPTENPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K357</accession>
    <name>F7K357_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250235.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00286"/>
    <dbReference type="EnsemblBacteria" id="EGN33427">
        <property type="protein sequence ID" value="EGN33427"/>
        <property type="gene ID" value="HMPREF0994_00286"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.309"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="258" mass="28171" checksum="63896C63862D6809" modified="2011-09-21" version="1">MKQQLLEIESLCKVYGKADNLTKALNGITFQVMTGEFLGIMGSSGSGKSTLLNCIATVIRPSGGRISMQGTDIHSLSGARLAEYRGKKIGYLFQNFELLDNLTGRENILLPLSLHNIPGKESGERLQSLADYLEITDVLDKFPAQMSGGQQQRIAAARALILRPDIILADEPTGALDSGNAKALMEKLSGLNRDQNATVLMVTHDTNAASYCKRILFIQDGVIFHELRRSLPEESRSEFYERILKVMAQLGGGSANVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3X7</accession>
    <name>F7K3X7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MotA_ExbB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_00556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250505.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00556"/>
    <dbReference type="EnsemblBacteria" id="EGN44744">
        <property type="protein sequence ID" value="EGN44744"/>
        <property type="gene ID" value="HMPREF0994_00556"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.604"/>
    <dbReference type="eggNOG" id="COG1291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079895_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="10">
        <location>
            <begin position="108"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN44744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="288" mass="32043" checksum="815BE6A00E78EEBD" modified="2011-09-21" version="1">MDILSIIGLILAVGMVLFGIMFDSDTTRVVLGNLHAFWDYPSLAITIGGTIGVMMLSFPPSAFKKIGKHMQIIFRPQKFDPRQSIQQIVELATEARMKGLLSLEDKLNEIDEPFLHNSLMLVVDSVDSEKVKAAMETELDQLDARHALDRSFYEKAASFAPAFGMIGTLIGLILMLGNMQDVNALASGMAVALITTLYGSLLANIVCLPVASKLKARHEEEFLCKQLVMEGVIAIQEGENPRYIEEKLYKLLPAHMKLGKEEEEGSEEESGTPRRFGRRKKNNQDKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K447</accession>
    <name>F7K447_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44826.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359857.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00638"/>
    <dbReference type="EnsemblBacteria" id="EGN44826">
        <property type="protein sequence ID" value="EGN44826"/>
        <property type="gene ID" value="HMPREF0994_00638"/>
    </dbReference>
    <dbReference type="GeneID" id="29725616"/>
    <dbReference type="eggNOG" id="ENOG5032WFT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723179_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046097">
        <property type="entry name" value="DUF6033"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19498">
        <property type="entry name" value="DUF6033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44826.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="382" mass="42760" checksum="C67ABFEE620A33CC" modified="2013-09-18" version="2">MIRAESCQFGKNLYMYPGERAADALKQTELPLAFNDRVKTKDVMRSSVPANGESGLKTSDALKEEEYIRYLESLFPGRSISVADLSGKDSIKDYALSHKGSFQIVISRETLERMQKDPEFEKKCMEALKSARQEQAGKLGKLPSQGKHLLGCGLVLDKDGEVTQWVLSQKDIQPKPVSNSSGIRNVGKEDGSYFRIRTEKGTMTIEKKKLRYVPAKDLVKIARAGNRQAVRRTISGIQAQINQLKSGSGDRRTKAVLVKQAEQVLLKAKLKDKLLKKEEILQLQQKKAAKKAEYEKSLRLKLLLKKKREGRKVREYGQIRDYYETPQERRLEKELEKYENSVETDTTCQDQSYGSYGAAAGMGPSAGGADISMAGGILDITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4F7</accession>
    <name>F7K4F7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250687.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00738"/>
    <dbReference type="EnsemblBacteria" id="EGN44087">
        <property type="protein sequence ID" value="EGN44087"/>
        <property type="gene ID" value="HMPREF0994_00738"/>
    </dbReference>
    <dbReference type="GeneID" id="29724208"/>
    <dbReference type="eggNOG" id="ENOG503259N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1684322_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356403" evidence="1">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="156" mass="17219" checksum="2AF6B255C7697147" modified="2011-09-21" version="1">MGKRILVLLLAIGIVMNVPLKINAAEIVEYNSDIQILSKSVVSGNRTRSGEPFLYDCELAIGIAKNGVAVEFATRCSEIATEIGVKDVVLQEKTLFGWRDIIIKDHSIEDDSLYAGAVVYVKAEAGKTYRVSCTHYAIVDDVELTLDNYTDEIVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Q1</accession>
    <name>F7K4Q1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00830"/>
    <dbReference type="EnsemblBacteria" id="EGN43382">
        <property type="protein sequence ID" value="EGN43382"/>
        <property type="gene ID" value="HMPREF0994_00830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.906"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100550_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="241" mass="28170" checksum="68D239A172F71324" modified="2011-09-21" version="1">MAYKQELWQEAKKRCRLGDEEIRMAKEMGLNPKSLIKNIPGPKESWKAPVKYWIRDMYEERQINAAQKPKKAERSILLFPEFQNMELIEGIRKQYDPFVSLISPHITLVFPFVSRYKEKDVKELVKEKSKAFSPFRLSMQGIVKYQENGEQYLFLQVKEGAEEIRRLHDSLYQGMLAAFKKDIPYVPHMTVGKLSSAEELDTAWEQVKDMNVVFQTEIKHITVEKIGEKGESITEAEIPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Q5</accession>
    <name>F7K4Q5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250783.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00834"/>
    <dbReference type="EnsemblBacteria" id="EGN43386">
        <property type="protein sequence ID" value="EGN43386"/>
        <property type="gene ID" value="HMPREF0994_00834"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.911"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="28584" checksum="9B222091B3498926" modified="2011-09-21" version="1">MSGNFLEIKNMKKTFGELEVIKDISLSVKEGEVVSVIGPSGSGKSTLLRCATMLEKMDGGELSYLGERAAYEENGKCVYVSKADRKRIHKYFGLVFQNFNLFPHYSVLKNIIDAPMTVDGISRKEAEERAEKLLAQLGLSDKRDAYPYQLSGGQQQRVSIARALALQPKILFFDEPTSALDPELTGEVLKVIRQLAQEHMTMIIVTHEMQFARELSDRIIFMEQGVICQEGTPEELFNSPNARVREFIGRVMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Q7</accession>
    <name>F7K4Q7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polar amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250785.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00836"/>
    <dbReference type="EnsemblBacteria" id="EGN43388">
        <property type="protein sequence ID" value="EGN43388"/>
        <property type="gene ID" value="HMPREF0994_00836"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.913"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363711" evidence="3">
        <location>
            <begin position="28"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="69"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="32467" checksum="735EE96F9E6D5F20" modified="2011-09-21" version="1">MKKAVAILLAGMMVFGLAGCGSKTSEGAGSEAVSAPESSAAAESTVTESTADTQEAESTAAADTGEGRQFVVGFDAEFPPYGYKDGSGEYVGFDLDLAAEVCKRQGWELVKQPIDWDSKDMELDSGAIDCIWNGFTMNGREDQYTWSVPYVDNSQVFVVADDSGISVKADLAGKAVGVQKDSSALAALEGDEKELADTFGALNQYADYNTAFMDLEAGAIDALAIDIGVANYQISSREGGYVILEGADHAEYLSTEQYGIGFKKGNEELKDIVEATLLEMVDDGSFMTIAEKYADYGLLDSICLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4R8</accession>
    <name>F7K4R8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250796.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00847"/>
    <dbReference type="EnsemblBacteria" id="EGN43399">
        <property type="protein sequence ID" value="EGN43399"/>
        <property type="gene ID" value="HMPREF0994_00847"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.925"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="232" mass="25803" checksum="95327774D575DF01" modified="2011-09-21" version="1">MNELVTITGLSKTYGHFTALNNMNLVIPRGRIIGLLGPNGSGKTTLIKLLNGLLTPASGQILINGHTPGVETKAMISYLPERSYLTSNRRVEDLVEYFVDFYDNFNKEKALGMLESLHIDLHARLKTLSKGTKEKVQLVLVMSRDADLYILDEPIAGVDPAARDFILKTIIGNYNENATILLSTHLISDIEAVLDDCIFIRDGQVMLCSSVEEIRETYGKSVDSYFREVFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4V4</accession>
    <name>F7K4V4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase RecG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250832.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00883"/>
    <dbReference type="EnsemblBacteria" id="EGN43192">
        <property type="protein sequence ID" value="EGN43192"/>
        <property type="gene ID" value="HMPREF0994_00883"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.963"/>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024970_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_4" evidence="2">
        <location>
            <begin position="287"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="489" mass="55228" checksum="FEAE9BCEFD754062" modified="2011-09-21" version="1">MKITDFIGEATEYDKKEMLEERRPRSWLKSVSAFANGIGGALIFGVSDDEIFVGLMDARAASEKISEAIKIKMDPIPQVIMENYTEAGKDFIILKVLPGQETPYYYVADGNRIAYVRVGNESIPADATALKRLVLRGTNMTYDSVVSSYMLQDFSFTKLRSVYRMRTGAELTDSDFISFELADESGKLTNAGALLADESPMRHSRLFCTCWYGLDKASGIMDALDDKEYSGSLVSLLQNGTEFVKNNTKKRWKKTGTGRVEMPEYPEQAVHEALVNALIHRDYMEIGSEVHIDIFDDRMEIYSPGGMFDGSIVQNLDTDYVASKRRNPVIADIFSRMHFMERRGSGFKKIKADYRRAENYRKEVEPLFRSTPTSFFVTLYNLNYNIPIEKTGLAEKKQAFNVEKTGLQEEKQAFETRIAGLDVTAPTKGNIMKIYQKFGDNIVFSRADVMKVTGLTATPATELMRKLRNNGLIESAAGRGKYRFSETQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K548</accession>
    <name>F7K548_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroK</name>
        <name evidence="3" type="ORF">HMPREF0994_00986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00986"/>
    <dbReference type="EnsemblBacteria" id="EGN43295">
        <property type="protein sequence ID" value="EGN43295"/>
        <property type="gene ID" value="HMPREF0994_00986"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1077"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057607_4_1_9"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="173" mass="18794" checksum="55CFCC3B42A368F4" modified="2011-09-21" version="1">MLMGTKDNIVLIGMPGAGKSTVGVVLAKALGCRFLDSDLVIQEETGRLLHEIISEDGVDGFLEIENDVNSRIETSRSIIATGGSVVYGEQAMHHLKEIGTVVYLELSCEEIGKRLGDLRKRGVALKAGQTLEELYAERVPLYEKYADVTIGCGGKRLRQIVSELSAVFQPEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5B0</accession>
    <name>F7K5B0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN43012">
        <property type="protein sequence ID" value="EGN43012"/>
        <property type="gene ID" value="HMPREF0994_01039"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3389986_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="32" mass="3922" checksum="174C0F198612B295" modified="2011-09-21" version="1">MTDQDRKLPARDKDIGRALFYNRNKIDRREDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5R2</accession>
    <name>F7K5R2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251140.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01191"/>
    <dbReference type="EnsemblBacteria" id="EGN42592">
        <property type="protein sequence ID" value="EGN42592"/>
        <property type="gene ID" value="HMPREF0994_01191"/>
    </dbReference>
    <dbReference type="GeneID" id="29724381"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="123" mass="13995" checksum="DEAA621EE44C5855" modified="2011-09-21" version="1">MNFLNLSPAEAEIMDLLWEGGERTNRELLISLNANGRDWKRQTLNTLLTRLIAKDLVKKSGHKFAAKLSKEEYSSVQTRSILETMYDGSLVNFVTAFAGGCQLSEEEASELRKLLDEKDWDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5W2</accession>
    <name>F7K5W2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251190.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01241"/>
    <dbReference type="EnsemblBacteria" id="EGN42488">
        <property type="protein sequence ID" value="EGN42488"/>
        <property type="gene ID" value="HMPREF0994_01241"/>
    </dbReference>
    <dbReference type="GeneID" id="29725493"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1357"/>
    <dbReference type="eggNOG" id="COG3395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029424_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="247"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="421" mass="46375" checksum="593223FB53054EF5" modified="2011-09-21" version="1">MKKRIGVVADDVTGANDIGVMFRKGGYRSAVFPLSLLSLCDLKGECEELDAIIIDTDSRFDDPRTAADKVAQATRLLQELPCDRYFNKTCSVFRGNIGAEFDSMQDVLGVSCSMVIAGFPGNGRTTVDGVHYVYGTRLEDSQFRTDPIHPMDISFLPDIMSRQTDRKISQITWEDLDKGLEHVIGKKEELKKQCAYILFDIRHQEDLKLVARAVADEINLCGSSAIGEELPAAIREMCEDGQDPVFLIAGSLTRQSIAQTEYLRGKGYPVITFDTETIFDEEAFSREEERLAGEALKAMKQAPLVLVHSAQQPERVQATKEKGQKLGFSHEEIGKQISGCLCRVTRRVLSETGCRKLVVAGGDTSAAVTGELEIYRMEIGEEIEAGVPAMTGKTNLGEMSLVLKSGSFGSESFLEKAARYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5W9</accession>
    <name>F7K5W9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-mann_mid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251197.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01248"/>
    <dbReference type="EnsemblBacteria" id="EGN42448">
        <property type="protein sequence ID" value="EGN42448"/>
        <property type="gene ID" value="HMPREF0994_01248"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1365"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="273"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="868" mass="97758" checksum="F04EF81AB86C2517" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6F9</accession>
    <name>F7K6F9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251413.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01464"/>
    <dbReference type="EnsemblBacteria" id="EGN41938">
        <property type="protein sequence ID" value="EGN41938"/>
        <property type="gene ID" value="HMPREF0994_01464"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1597"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060301_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="181"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="44676" checksum="4821D36F18C1DADF" modified="2011-09-21" version="1">MKLTFISNYINHHQIPFCNCFYQELREDFSFIQTEPMEEERVRMGWAVDAHAIPYVHLLYEEEEICRRLIDDCDLLLAGWMEKEELISARLGSGKPAIRISERIYREGQWKAVSPKGLIHKYKEHIRYRNKPVYLLCAGAYVASDFTLIHAYPGKKFRFGYFPEKRIYGSGELERMKGEGKEVQLVWAGRLMPLKHPEFVVRLGEDLKKKGYSFHIHLIGSGEMEETVKQDIQSRGLEDKITMYGFLDPARVRERMEKSHIHLFTSNHLEGWGAVVNEAMNSGCAVVANREAGAVPYLIEHGKNGMIYSGGSYEEFLGAVCFLMEHEEERRKMGENACQTIVSLWNAQNAAEQCLRFYDNWLQGKVEPPPEGPFSMAPVVWPGRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6S2</accession>
    <name>F7K6S2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01589"/>
    <dbReference type="EnsemblBacteria" id="EGN42063">
        <property type="protein sequence ID" value="EGN42063"/>
        <property type="gene ID" value="HMPREF0994_01589"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1738"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089592_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="144" mass="16594" checksum="257ED5DE7FB922AB" modified="2011-09-21" version="1">MMETNPYDYYEQCRFDAFCKAVLRNEARAYLRNMKRQRNRELTFSDLSQEELDKLYAVDRYPSDSFVFSAHGYELHIDNELVAEAFAKLSKTEQSILILHCVLDMADGEIGSLMGMSRSAVQRHRAKTLKALRVTLMALMPEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6W6</accession>
    <name>F7K6W6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002592127.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01633"/>
    <dbReference type="EnsemblBacteria" id="EGN42107">
        <property type="protein sequence ID" value="EGN42107"/>
        <property type="gene ID" value="HMPREF0994_01633"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1784"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_31_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="90" mass="10379" checksum="D751D841F4380833" modified="2011-09-21" version="1">MHISYKPLWHTLLERDMRKEDLRLAAGMTTNMIANMSKEGKHISMDTLARICETLNCEITDVIELVPDEPASTGGKEHERIETKNNRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6X6</accession>
    <name>F7K6X6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPr family phosphocarrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251556.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01643"/>
    <dbReference type="EnsemblBacteria" id="EGN42117">
        <property type="protein sequence ID" value="EGN42117"/>
        <property type="gene ID" value="HMPREF0994_01643"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1795"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="9200" checksum="56115A8876E3FC6A" modified="2011-09-21" version="1">MKMKAVKIQLSGGLEARPVAMLVQVASQHDSTVYLESEGKKVNAKSIMGMMSLGLDSGELVTVIADGPDEEVAVEDIAKYLCSGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K750</accession>
    <name>F7K750_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251592.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01679"/>
    <dbReference type="EnsemblBacteria" id="EGN41717">
        <property type="protein sequence ID" value="EGN41717"/>
        <property type="gene ID" value="HMPREF0994_01679"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1833"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_1_9"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="30"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN41717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="331" mass="38076" checksum="EFA56550606FA578" modified="2011-09-21" version="1">MIEKLYTIESGSLNPYLNMGLEEYLMYQTGKEECILYLWQNERTVVIGRNQNAWKECQTEELEGDGGYLARRLSGGGAVFHDLGNLNFTFLVRKENFSVEKQTEVILRAVNSLGIRAEKSGRNDITVDGCKFSGNAYFRTGDYCYHHGTILLHADRELMEKYLHVSDKKLESKGVDSIRSRVGNLCDWAPELNRERMAEKLKEAFGVCFGIPVEDFPGERLAGEEISRLAERFSSWDWKYGRQIPFSKETEERFSWGEMRIQLRVDGGRIQETRLFTDALDVELTERAEKCLSGLMFQKKAVRDAIDGIPTDNEMQARMKKDICGLMESFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K756</accession>
    <name>F7K756_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mutator mutT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251598.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01685"/>
    <dbReference type="EnsemblBacteria" id="EGN41723">
        <property type="protein sequence ID" value="EGN41723"/>
        <property type="gene ID" value="HMPREF0994_01685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003561">
        <property type="entry name" value="Mutator_MutT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00586">
        <property type="entry name" value="mutt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="8-oxo-dGTP binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="130" mass="15031" checksum="EECB44EA8C2E001A" modified="2011-09-21" version="1">MKSIQVVAAIIVDKNKIFVTQRGYGDFKGKWEFPGGKIEPGETPQEALIREIKEELLTTINIIDYITTIEYDYPQFHLSMQCYLCNIINGDLTLMVHSASAWEDISSLNNIDWLPADRVLIPFIQKRYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7E2</accession>
    <name>F7K7E2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251684.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01771"/>
    <dbReference type="EnsemblBacteria" id="EGN41584">
        <property type="protein sequence ID" value="EGN41584"/>
        <property type="gene ID" value="HMPREF0994_01771"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060270_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="354" mass="41255" checksum="FEF05D11D5BA4780" modified="2011-09-21" version="1">MEYCENWEQIRKKFLEYWAMENHDRPLVSIRAPKDRQEKKPESRHSSLKERWMDTEYVLKSSNWEMRNTYYGGEAFPSLNPNLGPDYFAACFGTKLEFGEDTSWSVPFLTDEDVEEYQGFKLCRQNEYYKKMLEITQAAVEDGKGKYLVGVTDIHPGLDGLVSMRGPQELCMDTLDQPEFIQKGAMDLLPGFREIYEELYTMTTKYQEGSTCWMGIWHPGRWYPTCCDFSCMISTQMYEELVVGELLEELDFLDASIYHLDGPDALKHLDRLLAIDKLKGIQWVYGAGQPTASHWIPVLKKIQDAGKMIQIDVVPEELDIMLENLKPEGVMYTINARTEEEGRALMKKVERYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7I6</accession>
    <name>F7K7I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251728.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01815"/>
    <dbReference type="EnsemblBacteria" id="EGN41628">
        <property type="protein sequence ID" value="EGN41628"/>
        <property type="gene ID" value="HMPREF0994_01815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1984"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="135" mass="15100" checksum="3BBB44EE4B3B21C7" modified="2011-09-21" version="1">MLITRETDYALRILRALAPGSCLTVGEIAEKESLPHKFTYKIMKKLEKAGIIRIIRGVNGGCQLDADLHGVSLYDLVNAVEANARLAACMTADYQCEWRDKNGSPCNVHGQLAKVQLAIDREFRSRSLYWVLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7X0</accession>
    <name>F7K7X0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41421.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360134.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02016"/>
    <dbReference type="EnsemblBacteria" id="EGN41421">
        <property type="protein sequence ID" value="EGN41421"/>
        <property type="gene ID" value="HMPREF0994_02016"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41421.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="30329" checksum="885CB1F73FF3479C" modified="2013-09-18" version="2">MKTKKIGKWVSFTLLILLILVFLFPYYVMITGAFKSQMALQLIPPDLNPFRNLTGKNAAYVWQKTEILLWLANSTAVSLGTAIITVFIGATAGYAFAKKRFRGQELIFALVIATMLLPRQMLLIPNYLVAMKLHLTNSRIGLILTTVSPAFGVFLCRQFMGSIPTELLEAAEIDGCGEIRRFIGIVLPMALPALGALGIFSFFSAWNDYLWQLIMIADKGLRTTPIGIALFSQGQITNTGYQLMAAMIATLPMLIIFLSCQKFFVKGITIGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K809</accession>
    <name>F7K809_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructuronate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251969.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02056"/>
    <dbReference type="EnsemblBacteria" id="EGN41461">
        <property type="protein sequence ID" value="EGN41461"/>
        <property type="gene ID" value="HMPREF0994_02056"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2257"/>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037833_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="2">
        <location>
            <begin position="38"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="3">
        <location>
            <begin position="239"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="538" mass="59386" checksum="CEE763C1DBC5EA6C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K849</accession>
    <name>F7K849_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252011.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41503">
        <property type="protein sequence ID" value="EGN41503"/>
        <property type="gene ID" value="HMPREF0994_02098"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZNGF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731140_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="43938" checksum="15B961CC16833CC7" modified="2011-09-21" version="1">MSYFVSDFVQFFTLMLGEEMGNNFTYDEICQQICLFLRVTIRNQKMIQEDVVKKCEDNGFCISQATISNIMNETGGKSISLRTLFAICKSLSIPMSELFYAIENNINIYDKLTQSKPKNKNRYFYLPSEDAYDGWFGKYHVYSFQTNKEKSLLHGILNLDPNKPAVHNSQECYAELILYTGENKRFKEYQGSAVASKKINAMYCRLESEKIGEIIYLTFYHWPFTSSNNELVCEMAVVITTSSGHQHLPTAQRIFLCRKELSEDEQEILKGHLRLNKAEMLLSEKEYIDFIKNTDIPEEFRARLKEKASKETYYSVAESELMLNHKEDISFIKSLSLLRNHTKAPNNNKISNNTNNYLYKLFKQNDSSHAKKSNNKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K898</accession>
    <name>F7K898_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin-crossreactive antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41276">
        <property type="protein sequence ID" value="EGN41276"/>
        <property type="gene ID" value="HMPREF0994_01871"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2050"/>
    <dbReference type="eggNOG" id="COG4716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024043_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363571" evidence="1">
        <location>
            <begin position="32"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="575" mass="64805" checksum="F22BEF9269C014A2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8G3</accession>
    <name>F7K8G3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252056.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02143"/>
    <dbReference type="EnsemblBacteria" id="EGN41050">
        <property type="protein sequence ID" value="EGN41050"/>
        <property type="gene ID" value="HMPREF0994_02143"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2344"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681159_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="51"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="396" mass="45829" checksum="E3227548EFC57C17" modified="2011-09-21" version="1">MRNIPVLFVKKIKNKITYLRSLYIGKKYIKKEEHIECHDKFSQVTYPYVGNAGDTVLSQCVRRFFEGKVSNTGWNIIEVPNSITQKTIDGINATKALIIGGGGLFLPDTNRNDISGWQWAVSKKQLQDINVPIIVYTVGFNYFKGQIPSELFIENLRILCNKANFVGLRNKGSVEAIRELLPDELKDKIKYQPCTTTFIRKIYADTLPIKEESKLVAFNMAFDRSERRFKGQKEEICNAVAMVAKRIEELGYKIVLVYHVKSDEQIAPYMKRHGVKFTIKDMTYSIPNEVYRFYNGVQCVIGMRGHAQMIPFGLNCGIVSLGTHDKMRWFLDDIGAADWYIDLTVETSTISDRIFETFKRTQISEREITWTRLLKAQEFLWSVTEENWWEIGKYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8I7</accession>
    <name>F7K8I7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252085.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02172"/>
    <dbReference type="EnsemblBacteria" id="EGN41079">
        <property type="protein sequence ID" value="EGN41079"/>
        <property type="gene ID" value="HMPREF0994_02172"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2377"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN41079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="29552" checksum="6F62F8D93371B309" modified="2011-09-21" version="1">MALNKVEICGVNTSKLTVLTNEEKTQLFERIKEGDEEARQKYIKGNLRLVLSVIKRFSNSNENVDDLFQIGCIGLIKAIDNFDSTLNVKFSTYAVPMIIGEIRRFLRDNNAIRVSRSLKDTAYKAIYAKENLMKQNQKEPTIAEVATEIGISKEDVVYALDAIQNPMSLYEPVYTDGGDTLYVMDQISDKKNKEETWVEHLSLSEAMKKLNEREFEIISLRFFEGKTQMEVAELIGISQAQVSRLEKNALKVMKNYLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Q0</accession>
    <name>F7K8Q0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RelA_SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41151.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359785.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02244"/>
    <dbReference type="EnsemblBacteria" id="EGN41151">
        <property type="protein sequence ID" value="EGN41151"/>
        <property type="gene ID" value="HMPREF0994_02244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077095_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="55"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41151.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="224" mass="26057" checksum="5FC90EA2F3B938B5" modified="2013-09-18" version="2">MEYFEMDITEKEKDLYGDQLILLTGTLTEFLSCMEMLRRYRKAVTGRDPVSSCRARIKKADSMTEKLRRMDLEVCRENALQKVYDAAGVRIICPFVEDVYSMVDLIMEIPGVRLFQAKDYIASPKPNGYRSYHMIIHFPLRFMGEAGADNSLWLELQLRTIAMDCWASIEHGLKYKKDISNQEFMKKELKRCADEIASTDLSLSTIREMIRENQEGRDGDKCVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Z9</accession>
    <name>F7K8Z9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252197.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41203">
        <property type="protein sequence ID" value="EGN41203"/>
        <property type="gene ID" value="HMPREF0994_02296"/>
    </dbReference>
    <dbReference type="GeneID" id="29723876"/>
    <dbReference type="eggNOG" id="ENOG50328S8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2569454_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="81" mass="9542" checksum="7C10E8C0303B0899" modified="2011-09-21" version="1">MTQIKIQIKQNYIKNNMNTYLPANNNPPVPTREEFHRQYAGSICPPDFSTEYPSSHITDRIARSLQLYREKRTELPCTNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K938</accession>
    <name>F7K938_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_02376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252277.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02376"/>
    <dbReference type="EnsemblBacteria" id="EGN40775">
        <property type="protein sequence ID" value="EGN40775"/>
        <property type="gene ID" value="HMPREF0994_02376"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2599"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="346" mass="37880" checksum="64C9B7022CC8890D" modified="2011-09-21" version="1">MKHRIYRHKPVLFCLILLFLLSDVFLTGCSRRTEPQTETGFYFNTVISITVYHPKDAVYLEDCFSLCDTYEKMLGRTVEGSDIYRINHSSGEPVAVSEETARLLEQACNYARLSGGKIDPTVAPLDDLWNFSGQAGTESAQKRIPADADIQSVLPHINYKNIHIENTTVILDDPMSQIDLGFIAKGYIADKLKELLKANGVQSALINLGGNVVVLGSKPDGSPFTIGMQKPFDEHGKAIATLSLSDSSLVSSGVYERYFRQDGRLYHHILDPASGYPVENGLLGVTILSGSSMEGDALSTTCFVLGLTEGMKLIESLPDIEAVFITEDYQLHPSSGLSGILFEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K949</accession>
    <name>F7K949_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SpoIID/LytB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252290.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02389"/>
    <dbReference type="EnsemblBacteria" id="EGN40788">
        <property type="protein sequence ID" value="EGN40788"/>
        <property type="gene ID" value="HMPREF0994_02389"/>
    </dbReference>
    <dbReference type="GeneID" id="29725090"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2616"/>
    <dbReference type="eggNOG" id="COG2385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021203_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="3">
        <location>
            <begin position="521"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="876" mass="96192" checksum="EA2E8128413473D6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K978</accession>
    <name>F7K978_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein AF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252323.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02422"/>
    <dbReference type="EnsemblBacteria" id="EGN40821">
        <property type="protein sequence ID" value="EGN40821"/>
        <property type="gene ID" value="HMPREF0994_02422"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2654"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021639_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="486" mass="55511" checksum="3835419D99401F0C" modified="2011-09-21" version="1">MASEATDSKEKMATSLEANMLYMNKVIKADKNFDVIYRVIQVGGKNACIYLIDGFCKDEMMQKLLQHFMDITEDNMPKDAHEMSKGFVPYVEVDLKDTWEEILYSLMSGVFLLFVDGFDKCILIDSRTYPARGVEEPEKDKVLRGSKDGFVETIVFNTALIRRRIRSTDLVMEMMHAGKTSKTDIVLCYMDNRVDHAFLEKIRDKIKNIQVDALTMNQESLAECLYDRRWYNPFPKFKFTERPDTASAQVLEGNIVILVDNSPSVLIMPTSIFDVVEEADDYYFPPITGTYLRFSRFIIALLTYLMTPTFLLLMEYPHLIPKGFEFIMVRDTVNVPLIWQFLILELAIDGLRLAAVNTPNMLSTPLSVMAALVLGEFSVNSGWFNSEVMLYMAFVAIANYTQSSYELGYALKFMRIINLILTAVFGVWGYGAGILLTVIFMVTNRTVSDQSYIYPVVPFNAKQLAKRLFRLRLPGALDPVDKKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9I2</accession>
    <name>F7K9I2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252444.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02543"/>
    <dbReference type="EnsemblBacteria" id="EGN40942">
        <property type="protein sequence ID" value="EGN40942"/>
        <property type="gene ID" value="HMPREF0994_02543"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2787"/>
    <dbReference type="eggNOG" id="ENOG502Z9M3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011652_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357202" evidence="2">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="30628" checksum="DD3517462232D6E5" modified="2011-09-21" version="1">MKKAIVLSLALTLALGMTGCAKTENAPAAESSVEAVSEASSEAAEETTTEAAEETSTAAEEASKSEGVLNYEEYMAAELDSEVVVETYVQAKQSWWEDKATVYTQDQDGAYFVYNMACSEEDYEKLVPGTKIKVTGYKSEWSGEVEITDAAFEIVEGDTYLAPVKDVTAMLGTDELIDYQNQYVAFKGMTVEAAGQDESGNDVAYLYNWDGSGTDGDDLYFSVSLNGETYSFVVESYLCDNTTDVYAAVKNLQIGDVIDMEGYLYWYEGVNPHIISVTAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAD6</accession>
    <name>F7KAD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAK2 domain fusion protein YloV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252663.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02762"/>
    <dbReference type="EnsemblBacteria" id="EGN40371">
        <property type="protein sequence ID" value="EGN40371"/>
        <property type="gene ID" value="HMPREF0994_02762"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3021"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017496_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="562" mass="60968" checksum="509C97018B35894A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB45</accession>
    <name>F7KB45_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252977.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03076"/>
    <dbReference type="EnsemblBacteria" id="EGN40253">
        <property type="protein sequence ID" value="EGN40253"/>
        <property type="gene ID" value="HMPREF0994_03076"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3361"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_0_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="266" mass="30129" checksum="F12EC671840CC1A5" modified="2011-09-21" version="1">MGKRRVEVRGWMTVGQAAKKGGVTVRTLQYYDKEGLLSPTAVSEGGRRLYTDKDVVRLHQILSMKSLGFSLDDIKNRLIPLDTPGDVAEVLSKQAAALREKIESLSESLKAIEALREEVLQMHSVDFGKYADIVVNLQMKNEYYWLIKNLDDRALECFRGRFDKDSGQAMLETFTRLQEEAVRLQNSGEVPESEKGMELAEAYWDMIMEFTDGDMSLIPGLMETEKLEDPGGKWKNKQAVVHSFIEPALEAYFTKTGYDPFEGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBA8</accession>
    <name>F7KBA8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="2" type="ORF">HMPREF0994_03137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253038.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03137"/>
    <dbReference type="EnsemblBacteria" id="EGN39967">
        <property type="protein sequence ID" value="EGN39967"/>
        <property type="gene ID" value="HMPREF0994_03137"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3430"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_6_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="129" mass="14248" checksum="5E406D8831ADEB7B" modified="2011-09-21" version="1">MRKNSVKNTRINSEVQKVLAETIRGEIKDPRIAPLTSVVAVEVSPDLKTCKAWISVLGDEAAQKETMAGLRSASGFIKSRLAKEINLRITPEVQFIMDQSIAYGVNMSHKIDEVMGSQDMARDAEADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBB6</accession>
    <name>F7KBB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_03145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253046.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03145"/>
    <dbReference type="EnsemblBacteria" id="EGN39975">
        <property type="protein sequence ID" value="EGN39975"/>
        <property type="gene ID" value="HMPREF0994_03145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3438"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="331"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN39975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="574" mass="63675" checksum="BA4C9D1427B33258" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBG8</accession>
    <name>F7KBG8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_03202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253103.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03202"/>
    <dbReference type="EnsemblBacteria" id="EGN40032">
        <property type="protein sequence ID" value="EGN40032"/>
        <property type="gene ID" value="HMPREF0994_03202"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3498"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086592_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN40032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="225" mass="24216" checksum="4D13186F3B8735EB" modified="2011-09-21" version="1">MKHYGVFDMIGPVMVGPSSSHTAGAARLGLFARHLCGEEIKKAVCYMHGSFAETYAGHGTDKALLAGIQGIRYDDERLKSAYELAGQKGIQAEFIPADLGEVHPNTVHMELTTESGNVFTMTGSSIGGGSICITEIDGVEVQFSGERPILATRHTDEPGVIAGITAILYAYRINIGNMQVNRTEDGKTACMYMELDGELPEHLKNALERVYGVKQVLLLNPGDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBI3</accession>
    <name>F7KBI3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Germination protease</fullName>
            <ecNumber evidence="1">3.4.24.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GPR endopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Germination proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spore protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpr</name>
        <name evidence="2" type="ORF">HMPREF0994_03217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates the rapid degradation of small, acid-soluble proteins during spore germination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase action with P4 Glu or Asp, P1 preferably Glu &gt; Asp, P1' hydrophobic and P2' Ala.</text>
            <dbReference type="EC" id="3.4.24.78"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.78" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253118.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03217"/>
    <dbReference type="EnsemblBacteria" id="EGN40047">
        <property type="protein sequence ID" value="EGN40047"/>
        <property type="gene ID" value="HMPREF0994_03217"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3516"/>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055087_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00626">
        <property type="entry name" value="Germination_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005080">
        <property type="entry name" value="Peptidase_A25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03418">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019549">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01441">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005052209" evidence="1">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023312110" description="Germination protease" evidence="1">
        <location>
            <begin position="10"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="32965" checksum="A2B08794AAC5BC65" modified="2011-09-21" version="1">MSCFQVRTDLALEARESITDADGELRGVRVEEFHNPKSEVQITRVIIDTKNGAKAMGKPMGTYVTLEAPALIEPDEDYHREVSEELAKQLRNLIPDIEKEQSILVVGLGNRDVTADALGPEVVDNLFINRHVIKEYGKAAYGCEKMHMISSIVPGVMAMTGMETAEIVKGVVEQTKPDALVVVDALAARSTKRLNRTIQVSDAGIHPGSGVGNHRNAINKESLGIPVIAIGVPTVVDAATIVGDAIESMIQESGEEGYFFNREHPKALSELNNMYVTSKDIDETVKRLSFTISEAINIALDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBQ1</accession>
    <name>F7KBQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253190.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03289"/>
    <dbReference type="EnsemblBacteria" id="EGN40119">
        <property type="protein sequence ID" value="EGN40119"/>
        <property type="gene ID" value="HMPREF0994_03289"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3596"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099729_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="24482" checksum="ABC58C4EA8A5355B" modified="2011-09-21" version="1">MMLGRLTVWDMKFQIKYGFYLLYSVLTVIYLIILLAMPESWRTAAAAILIFSDPAAMGLFFMGAIVLLEKSQKVPCAYAVSPVRAIDYIGAKVISLCTISIAVAAILAVAVKAEDLPRTLLGTALSGAVFTLLGIIIATKISSLNQFILWTVPIEVVGFVPAILHMFGVTPAVLRYYPLNVCMDMIAGKKITATGLFVVVLLIAVLIVAAHKCVRRMWKSAGGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBQ8</accession>
    <name>F7KBQ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase I alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253197.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03296"/>
    <dbReference type="EnsemblBacteria" id="EGN40126">
        <property type="protein sequence ID" value="EGN40126"/>
        <property type="gene ID" value="HMPREF0994_03296"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3604"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="3">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="475" mass="53826" checksum="42FE489EB1536A74" modified="2011-09-21" version="1">MGKSEKILQLCRENDIRMIDFKMVDLDGRFRHITIPVERFGERIFEYGIGFDGSNYGYAPIEKSDMVFIPDPDSAVMDPFVEIPTLSMTGDVCVIGEKENRPFDQYPRNVALRAVDYMKATGTADQMLIGPEFEFYLFDSVNYQVSPNGSFYEVDTRQAEWNTGTEEGGLGYQVKHKGGYHIAAPQDISYNLRSKMCMLMEDWGIRVKYHHHEVGGPGQLEIEVELGEMVDMADKTMITKYIVKNAAVKEGRTATFMPKPVYQEAGSGMHVHMLLFKEGRPVFYDKDGYSSLSQTAHYFIGGLLKHAPSLCAWTNPSTNSYKRLVPGFEAPVTIGYATSNRSAVIRIPAYAKAPEDKRFELRSPDATANPYYAYAAILMAGLDGIENRIDPSANGWGPYDYNLYELSSEQQAKIQSLPKTLEEALDALERDHDYLTKNGVFPERLIQIWLERKRKESRTISQIPHPAEFGAYYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBR2</accession>
    <name>F7KBR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253204.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03303"/>
    <dbReference type="EnsemblBacteria" id="EGN40133">
        <property type="protein sequence ID" value="EGN40133"/>
        <property type="gene ID" value="HMPREF0994_03303"/>
    </dbReference>
    <dbReference type="GeneID" id="29728655"/>
    <dbReference type="eggNOG" id="COG1936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102890_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="189" mass="21600" checksum="18051B8A1DF82308" modified="2011-09-21" version="1">MERRMEMKRLILLCGANGIGKSTASAELMKRLPHSSYIDSDYCRMTNPPIFNEELIRLNYKNILAMMENSFACGEIQNVIFPFGFHGHRKQLFDALLEELRQKGISFELVPVLLYCGEEENVRRARADGRDEERIRRGIRNSRAVYENVDYPRIDVTDMTAEETAEEILKLIGTGNEEETGNAVMGSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBT4</accession>
    <name>F7KBT4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253232.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03331"/>
    <dbReference type="EnsemblBacteria" id="EGN40161">
        <property type="protein sequence ID" value="EGN40161"/>
        <property type="gene ID" value="HMPREF0994_03331"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3642"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_36_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="158"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="457"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="598"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="850" mass="97840" checksum="58BE8450F2699320" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBV6</accession>
    <name>F7KBV6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_03353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03353"/>
    <dbReference type="EnsemblBacteria" id="EGN40183">
        <property type="protein sequence ID" value="EGN40183"/>
        <property type="gene ID" value="HMPREF0994_03353"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3665"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="487"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="601" mass="69724" checksum="E406E9DD24E3F3B8" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBY0</accession>
    <name>F7KBY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03300"/>
    <dbReference type="EnsemblBacteria" id="EGN40130">
        <property type="protein sequence ID" value="EGN40130"/>
        <property type="gene ID" value="HMPREF0994_03300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3608"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="35875" checksum="9582F9AB2AC00058" modified="2011-09-21" version="1">MKNFRFAIMGAGNIANKFCDAVKRMGDCEVAAVASKSMERAKGFAEKNGIKAAYDSYEKMLAEEKPDCVYIAVTQDAHYALCMLCLDYKTPVLCEKAMFLNSAQAEEVLSRAEKEKVFVMEAMWSRFLPAIKMAKQWMDEGKIGTPSFIDTAIGFLAPVDKDNRYYSPKLGGGASYDITVYAYELTTFMIEQPVEDVQVSAVWSDTGVDISDQVTLRFPGILASLRTSFAAGLHERMVIYGNEGKIVIPHPHFAEEVFLYDKNNELVMRFQDTVTENGFLYEIEEVANCIRDGRTESPVVPHSLTRECAKLFDRILETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBZ7</accession>
    <name>F7KBZ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">HMPREF0994_03376</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253277.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03376"/>
    <dbReference type="EnsemblBacteria" id="EGN39883">
        <property type="protein sequence ID" value="EGN39883"/>
        <property type="gene ID" value="HMPREF0994_03376"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3689"/>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_1_2_9"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGN39883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="27855" checksum="3FD6499281B80847" modified="2011-09-21" version="1">MKTVVSSLVIAFSMYSKIPMPRVEWTEENRKYAICFFPLVGLVTGGLCYVWFLICGHLQAGTLLFSAGMAAIPLFLTGGIHVDGFMDTMDAMHSYLPREEKLRILKDSHIGAFSVICLLGYYLTYLGWISELRSERAVLCFCLGFLLSRILSGLSIVYFPGAKKEGLLYAFSSTAHKRTVRLVLFLLLGVCVLGMVLVSPLAGSLTVAGNLAVFGWYGYDSKKEFGGITGDLAGWFLLCAEWVSAMVPAVIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBZ9</accession>
    <name>F7KBZ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03378"/>
    <dbReference type="EnsemblBacteria" id="EGN39885">
        <property type="protein sequence ID" value="EGN39885"/>
        <property type="gene ID" value="HMPREF0994_03378"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3691"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002982_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="32078" checksum="8946CB36EA5F3C53" modified="2011-09-21" version="1">MCADNGIIEEGVSQSGHEVTTVVTGNIAKGLASVNRMASCAGADVFPVDVGMKDDLKLKGLLVEKTRNGTRNFLKEPAMEDEDMLAAIRAGVEMTEMLSDGGYHILALGEMGIGNTTTSSAVASVLLGLPAEEVTGPGAGLDKEGVRRKIAVINQAAAAWKLGIHGPLSGDGEKDTQLMMQETLRTLRTVGGLDLCALTGACIGGAIYRVPIVLDGLITAVAALTACRLLPGVRDFLLPSHLGKEPAMAAIYEELKFCPVIHARLALGEGTGAVALFPLLDMACQVYRENATFGDLEMDAYEDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC00</accession>
    <name>F7KC00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253280.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03379"/>
    <dbReference type="EnsemblBacteria" id="EGN39886">
        <property type="protein sequence ID" value="EGN39886"/>
        <property type="gene ID" value="HMPREF0994_03379"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3693"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022752_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="3">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="4">
        <location>
            <begin position="255"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="478" mass="52427" checksum="B443C9540D4D7756" modified="2011-09-21" version="1">MSETAEEKKKRRPGAPRILIAGTGSGCGKTTLTCGILYGLVRQGYSPAAYKCGPDYIDSMFHSRVLGIETGNLDSFFTDDQTLRALLAGRQADIHVIEGVMGYYDGMGFTENGSASEIAALTKTPVILTVNARGMSRSVLAVLRGFLESQSWPGIKGVIFNQLSPVLYPDIRREAQKLGVCVLGYVPRLPEAAFESRKLGLVTPGEIEGFRDKLALLYDSLKDSLDWDGIWELAESAPDLTGFAAGEEKVFNGIKIAVAKDEAFCFLYQDNMEFLRHLGCEIACFSPLHDSGLPEGADALILNGGYPELYADRLEKNGSMRRSVKKAVENGMPVIAECGGFMYLHRRLQDEKGEYHEMAGVLPGDCYRTPKLSRFGYITMKAEKDNLLCRTGETLKAHEFHYYDSTCPGDAFAAQKGGGRAGWMAGVADKTMYAGFPHLYFYGNKKAAYAFVEAAEKYGKRRKNITISETVRGKDPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC35</accession>
    <name>F7KC35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253315.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03414"/>
    <dbReference type="EnsemblBacteria" id="EGN39921">
        <property type="protein sequence ID" value="EGN39921"/>
        <property type="gene ID" value="HMPREF0994_03414"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3732"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="291" mass="32962" checksum="FD9412CB9DE20805" modified="2011-09-21" version="1">MGIGIVIMGVLLFVSVLRLWSYDRQLKEWAEQLTQTDEYSNLRLGTSVRSRAFLNCCRAVNERLERGQQARIRQESMSRELKFTISCVSHDIRTPLTGAAGYLQLLENISDTDMQKSYIAIVRRRLEDLEGLLEELFLFTKLSNEEYQIECEEIAPFPALCDVLAGFYHKLTEAGVEPELYFQEESGMVYASAEALRRVFSNLVQNALRYGSGRLVIRQEGKAIHFTNPVEHPEELDTERLFQRFYRADPSRHTGGAGLGLASVKGLMEKMGGSVGAAVREGCLVVTLYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCU1</accession>
    <name>F7KCU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253571.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03670"/>
    <dbReference type="EnsemblBacteria" id="EGN39042">
        <property type="protein sequence ID" value="EGN39042"/>
        <property type="gene ID" value="HMPREF0994_03670"/>
    </dbReference>
    <dbReference type="GeneID" id="29728419"/>
    <dbReference type="HOGENOM" id="CLU_1123410_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="247" mass="26571" checksum="0E4E637EF8CAF4D4" modified="2011-09-21" version="1">MRTKKMQLSEHIGTYIIGTILLLLAAFLLFPPFPTAAAEAQSIALKEATARLSIGETKTIQVDYSKLKGGYADLGIAVSDPSLIQAALHDAGNSQAVLTIQAQGFGTASVAVYAVSNPAIVSYAAVYSGMAEKGEVYTITEGNTLITVYDDRLIYYNTTLTGKNGATLAVKGIELERSKGIDNLKVTGDLLQKDTKFPGLNTFYACFYDAAGDLIKRQAVYASDPISYNELTISWYLPEACTKIILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD16</accession>
    <name>F7KD16_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03745"/>
    <dbReference type="EnsemblBacteria" id="EGN38909">
        <property type="protein sequence ID" value="EGN38909"/>
        <property type="gene ID" value="HMPREF0994_03745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4087"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="305" mass="34419" checksum="87329AA40FCF6DCB" modified="2011-09-21" version="1">MGKNVKKTLVKAWNYKWIYLMLLPVVVYFLVFRYAPMYGITIAFKDYNIFKGIFDSPWIGFKVFEKVFANKNFWLAIKNTFVLNLTSLAVSFPLTIIVSLMLNELGSAKFKKVTQSILYLPHFVSWVVVAGIATNMFALQNGTINMLLQRLGFDAIPFLSEKGWWIFTYIVCHVWKEIGWGTIIYLAALTGVDESLYEAAYLDGASRFQRLIYITLPSIKSVIVTMLILSLSKMMSIGLDAPLLLGNNKVMGVSEVISTYTYRIGIEKALYSESTAIGLFQSVVNIIILLGADRFAKLIGEEGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDC1</accession>
    <name>F7KDC1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253754.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03853"/>
    <dbReference type="EnsemblBacteria" id="EGN38618">
        <property type="protein sequence ID" value="EGN38618"/>
        <property type="gene ID" value="HMPREF0994_03853"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4194"/>
    <dbReference type="eggNOG" id="COG4405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102450_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06553">
        <property type="entry name" value="ASCH_Ef3133_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009326">
        <property type="entry name" value="DUF984"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203">
        <property type="entry name" value="PTHR39203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021320">
        <property type="entry name" value="DUF984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="135" mass="15410" checksum="76C1DAD9D6118C46" modified="2011-09-21" version="1">MNSMENTNNDYFERFAFGDSPEMADELLALVLSGKKTATVSVILESDQKPNVGDLSLVLDGRGNPACVIKTVHLETVKFCDLTWDMVKLEGEDETFEQWKAGNIRYWTRDAARRGYTFNDQTPITFERFEVVEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDD3</accession>
    <name>F7KDD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253767.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03866"/>
    <dbReference type="EnsemblBacteria" id="EGN38631">
        <property type="protein sequence ID" value="EGN38631"/>
        <property type="gene ID" value="HMPREF0994_03866"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4209"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="256" mass="27417" checksum="0074CD490049A0EF" modified="2011-09-21" version="1">MKDLFDLKGKVAVVAGASSGLGADAARAYAEYGAQVALLARRKERLDELAEEITAAGGTAFAAACDVTAEESVKNAVEQVLTHYGKIDILLNNAGVAIKGSVEDTSAEDWDKVMDINVKGMYLMCKYVIPGMRSRQYGKIVNVASVNAVMASKTLARHSYNASKAAVRGLTMGMAATYMKDNITINSVGPGLFESEMTANTLFKNEEYLESYRKTNPASRPGRQGELNGTILYLSSDASSYVTSQHILVDGGYTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDE1</accession>
    <name>F7KDE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38639.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360304.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03874"/>
    <dbReference type="EnsemblBacteria" id="EGN38639">
        <property type="protein sequence ID" value="EGN38639"/>
        <property type="gene ID" value="HMPREF0994_03874"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38639.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="175" mass="19385" checksum="D27C0421DF8B5CDA" modified="2013-09-18" version="2">MNKGLIHLYTGEGKGKTTAAMGLALRAAGAGKKVLILQFMKGRDTGELHSIAHIPAIRILRSEKDFGFFSSMSQADKEALTKIHNRLLDEAVRQASAGEAELLILDEVTYPVNWGLLDVDKLKDFLKEKPEELELVCTGRDAADFIVDAADYITEMRCIRHPFEKGIPARKGVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDK7</accession>
    <name>F7KDK7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253853.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03952"/>
    <dbReference type="EnsemblBacteria" id="EGN38717">
        <property type="protein sequence ID" value="EGN38717"/>
        <property type="gene ID" value="HMPREF0994_03952"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4303"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN38717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="29212" checksum="8EE0E21D488307B9" modified="2011-09-21" version="1">MYTLLIVDDEPNILEGIKRLLDWKSLGVGRIETARSSLEVMSNILDWRPDICLMDVCIGNDKGYEVINCLNNLGVRSNYVMMSGYDEFSYACEAIRCGALDYLLKPVEKKKLLEVVRKIIVEKLHGTIPEEDEKKNCDPVLDMDYDAMSPLIHKIVMMVRVEYGGHISLKSIADKFRMNSTYLGQIFIKETGMKFSEYLMCYRLYVARERILNSDEKIAVIAADVGYSNMNYFYQHFHGYYHTTPSDMRMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDN6</accession>
    <name>F7KDN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253800.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03899"/>
    <dbReference type="EnsemblBacteria" id="EGN38664">
        <property type="protein sequence ID" value="EGN38664"/>
        <property type="gene ID" value="HMPREF0994_03899"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4243"/>
    <dbReference type="eggNOG" id="ENOG502Z918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055095_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="350" mass="41319" checksum="E169DCD9D05E3602" modified="2011-09-21" version="1">MANRLKDYFPLIRERKEVLKEIGSSMALSTLFDSWEQERQEEFLDFCTGVKGVKILYDSFFKEIMNPEYSPGRLNRFLSLLLGKRVTIKQVIPNDSTRIAAEGSLLVTDIVVEFEDGGLADIEIQKIGYAFPGERSACYSADLLLRQYKRAREKIQGRNRKFSYKNIKNVYTIVLFEKSPAEIKRLENAYIHKSFWGFDTGLELNLLQNFIFIALDIFRKNMDNKSVDNELDAWLMFFGSEEPERIIELIESYPDFREIYEDIYEICLNMEKVMGMYSKELQELDRNTVQYMIDEMQEIINEQKETIHTQTEVLNDQKQTISSQELLIKEQKQQYEELLRRVRDLENKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDW3</accession>
    <name>F7KDW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small GTP-binding protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253943.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04042"/>
    <dbReference type="EnsemblBacteria" id="EGN37567">
        <property type="protein sequence ID" value="EGN37567"/>
        <property type="gene ID" value="HMPREF0994_04042"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4409"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03711">
        <property type="entry name" value="Tet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035650">
        <property type="entry name" value="Tet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN37567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="898" mass="101946" checksum="027BAF2D25E2B4C9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE10</accession>
    <name>F7KE10_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000019">
        <property type="protein sequence ID" value="EGN37092.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04089"/>
    <dbReference type="EnsemblBacteria" id="EGN37092">
        <property type="protein sequence ID" value="EGN37092"/>
        <property type="gene ID" value="HMPREF0994_04089"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2928040_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN37092.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="61" mass="7191" checksum="59D1E7933F3AB705" modified="2013-09-18" version="2" fragment="single">CILYVAEKYSPSGGQPMIYFMENNIVIRRMQETDPQIFSDEECAQDWHASPEKYDISCKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE64</accession>
    <name>F7KE64_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04143"/>
    <dbReference type="EnsemblBacteria" id="EGN36936">
        <property type="protein sequence ID" value="EGN36936"/>
        <property type="gene ID" value="HMPREF0994_04143"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142044_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="177" mass="20476" checksum="1301C8EB028533FC" modified="2011-09-21" version="1">MEQTISCLFTVERRIVMEIREVGDGNAKKEICDTVLHRLPEWFGIEESIAEYVSLVEEMPFYGVYDGERPVGFLAVKVHNAFTAEVCVMGILKEYHRMGIGSELMERAEEYCQQKGLVYLTVKTLDGSVDFEPYERTRRFYEKMGFIPLEVFPLLWDEANPCLFLAKHLACSQEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE89</accession>
    <name>F7KE89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254069.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04168"/>
    <dbReference type="EnsemblBacteria" id="EGN36961">
        <property type="protein sequence ID" value="EGN36961"/>
        <property type="gene ID" value="HMPREF0994_04168"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4542"/>
    <dbReference type="eggNOG" id="ENOG50339TV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182788_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025346">
        <property type="entry name" value="DUF4250"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14056">
        <property type="entry name" value="DUF4250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="57" mass="6669" checksum="2021DBDAF8E5673A" modified="2011-09-21" version="1">MIPEDPVMLLSFMNMKLRDFYPSLDAFCDDCGADKEGIVKKLKGIDYIYDEERNQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF88</accession>
    <name>F7KF88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254285.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04384"/>
    <dbReference type="EnsemblBacteria" id="EGN35694">
        <property type="protein sequence ID" value="EGN35694"/>
        <property type="gene ID" value="HMPREF0994_04384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="433"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="531" mass="60919" checksum="9561AE417D75935D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFF3</accession>
    <name>F7KFF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04582"/>
    <dbReference type="EnsemblBacteria" id="EGN35351">
        <property type="protein sequence ID" value="EGN35351"/>
        <property type="gene ID" value="HMPREF0994_04582"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5001"/>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111529_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="215" mass="23039" checksum="47A32C7CDA7D53ED" modified="2011-09-21" version="1">MSSKTKIVVLHLKELIYTGIFVVLGILFLLLLIIMFLPGKKTTPEESGADEGRYTPGKYTTSLILGNSAVDVEVVVDDNNINSIRLVNLDEAVTTMYPLMEPALNDLASQICTKQSLEDITYSDDNKYTSQVLLDAITSALGKAEKNPGSSTKEKSQKSNTTLETIEESTAAPPAENAAENTTVNSTEGSGENTAENTNMETPADTPEETAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFH0</accession>
    <name>F7KFH0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">HMPREF0994_04599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254500.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04599"/>
    <dbReference type="EnsemblBacteria" id="EGN35046">
        <property type="protein sequence ID" value="EGN35046"/>
        <property type="gene ID" value="HMPREF0994_04599"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5020"/>
    <dbReference type="eggNOG" id="COG0829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056339_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN35046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="30866" checksum="28CF741DB9A09E46" modified="2011-09-21" version="1">MDKGTENAFGRKSELRLTAGWDGKETFLRELGFTAPFKIMTPFPCKDGGKEVMIMCASPGIMEGDSQWIRIETEKGARLAVTSQSYEKIHKMNNGCACRNTIIRIAGNSALRYRPLPVIPFGGSAFESRTAIELEDESSELIYEELLSCGRAACGERFAYRFFHSLSEVSCKGKLIYRENNRFRPASWPMEELGLFEGYTHMAGMLIHMQAVKEKEREIRSLAEDAENDQEVQSGVTRTAAGDLVVRILGRRAENVRKICDEICSCMEYSVPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFJ6</accession>
    <name>F7KFJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254526.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04625"/>
    <dbReference type="EnsemblBacteria" id="EGN35072">
        <property type="protein sequence ID" value="EGN35072"/>
        <property type="gene ID" value="HMPREF0994_04625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5049"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="407"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="511" mass="59351" checksum="6CB051042D7B9528" modified="2011-09-21" version="1">MAYKVWIVDDEEIVCRGLAQFVKWQEHGFVVAGIANSVDEALLQLEHAEADVIFLDIRMPGKTGLDMLQILRKSRPGVKTVILSGFSEFSYAREAIRYGAVDYLTKPVNLKEVEALLERLKEEFEKEDREQEIRDNRIEGLLISVVKGVAEVEQEKYQLPELEQWYGFSARLLDNEISDEELAEKKEELRRNIKAVVPGSYILDQDVYGVFAIVPCSEEAEAENFVVMLEQTCRVEQEWACGLSKYKRGIRDLREGYREAEYALRYHMAREMHGIVWYKNIETLFSQSAPEVPDIVKDLTGRLMNPEERSGVAEQMEQALENICLQRPVIMQFQTTCIRCLIEMNSLLEGMDLKGLDLHGQLNKALEKILFCNEYKATIGCMTDYVRFLAAGLERTDEKQLGKGVIREIQLFIRQNYSKNITLNMLAEQFYLHPNYLSRLFKEKTGKNFVEYMTEIRMEQVKKLLENPENRIADISIMVGYDNARYFNKVFKQYMGMTPSEYREKVLKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFU5</accession>
    <name>F7KFU5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04724"/>
    <dbReference type="EnsemblBacteria" id="EGN34650">
        <property type="protein sequence ID" value="EGN34650"/>
        <property type="gene ID" value="HMPREF0994_04724"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5155"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363744" evidence="2">
        <location>
            <begin position="29"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="439" mass="48391" checksum="720486235F0F9BDC" modified="2011-09-21" version="1">MKKWNKLLALGMAFSMTLALTACSGQSADTSGEAAEPQSAAPSTAVSDSADASEAGEEKTYEPTTLTFWNGFTSTDGEVLQQIVDDFNASNEWNITIEMDVMPWATFNEKLPAAIAAGNAPDFVLCSSGYYAPYVEAGSFQDVSDFYELPEVNADDFDKNVVDLLYYDDLCVGVPMQMVSHYFYWDKDLYEAAGLDPESPPETFEELVENAKLLTDKSKNQYGFCVPVNNNVTAQYTMYAYGGGYVNEDETEAVFNSEENVKAFETLKTLYECSPKDSDDNTYISGQLAQFINGPWIINGLRENEINYGVKAVPACTGVEQDAAVIPVGFSIPKTTSEEHKELVYKFVNYWNTEEICTKWTKECGTPAYLLSAQANFADDPQTLALSEPLSYGHIECKLNGVNTISTDGLYPAMEEIFAGADIKTTLDKYNEVIQGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFW2</accession>
    <name>F7KFW2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04741"/>
    <dbReference type="EnsemblBacteria" id="EGN34667">
        <property type="protein sequence ID" value="EGN34667"/>
        <property type="gene ID" value="HMPREF0994_04741"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5176"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_9_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="85"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="349" mass="38388" checksum="CC507441E7745734" modified="2011-09-21" version="1">MRDNLGNADREKKQDMQEKPVHGFFYHLFGILKAAALIIIFLIAASAALHQTMTVWEKGRTPPAGDLVTADGHKMSIYVTGRGENTIVLLPGLGTAAPILDFMPLAQALARENRVVVVEPLGYGWSDTTKEARTVENTVEELRSALKAEGLDGPYVLMPHSISGIDALYYANTYPDEVCAVIGIDCTLPAMPDYFGEGEPAQVPAVLGLLNPVGIIRWSCMLNPDAYISDNSSGLYTPGNLAMQKRIAARMGQNATVIDQMNRIGDNLEITRDMKFDSQLPLLFFTRDGSSQEAREDGKSSGSFYQTYVSNEECQRVVPLNGGHYLHWTCSEEMAEEVGVFLRTMSDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFY8</accession>
    <name>F7KFY8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_04767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04767"/>
    <dbReference type="EnsemblBacteria" id="EGN34394">
        <property type="protein sequence ID" value="EGN34394"/>
        <property type="gene ID" value="HMPREF0994_04767"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5205"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="474"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN34394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="586" mass="67341" checksum="5344BA777FF50655" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG27</accession>
    <name>F7KG27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254707.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04806"/>
    <dbReference type="EnsemblBacteria" id="EGN34433">
        <property type="protein sequence ID" value="EGN34433"/>
        <property type="gene ID" value="HMPREF0994_04806"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2898472_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="62" mass="7448" checksum="DB6B9824CDC5825F" modified="2011-09-21" version="1">MLVSEIKEVIKEYPEEDLRLLIVELYKAMPQKKMRPRGETRERIRQMHSRKSAFKKGMGMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGG4</accession>
    <name>F7KGG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore maturation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254844.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04943"/>
    <dbReference type="EnsemblBacteria" id="EGN34112">
        <property type="protein sequence ID" value="EGN34112"/>
        <property type="gene ID" value="HMPREF0994_04943"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5399"/>
    <dbReference type="eggNOG" id="COG2715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089992_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="201" mass="21633" checksum="9BE536AC8A0E8050" modified="2011-09-21" version="1">MLNYIWAVMIAIGVIYGALTGNIEAVANGALDSAGEAVQLCITMTGIMALWVGLMEIAKNSGLIASMTKGIQPFISFLFPRIPGNHAAREYISTNIIANILGLGWACTPAGLKAMEELQKLNEEECRRTGKPPVTASNEMCTFLIMNISSLQLIPVSIIAYRSQYGSVNPTAVIVPGIIATLTSTLVAIIFVKVMDRKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGL7</accession>
    <name>F7KGL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04996"/>
    <dbReference type="EnsemblBacteria" id="EGN33791">
        <property type="protein sequence ID" value="EGN33791"/>
        <property type="gene ID" value="HMPREF0994_04996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363759" evidence="2">
        <location>
            <begin position="28"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="453" mass="49016" checksum="1466D71C5840CC82" modified="2011-09-21" version="1">MKKKVLSMLMGVSILAAALAGCGKAPASTENSAPAPAATDSAQAAETPEAAESAAGTQASGEKKTVQFWHCMSGTNGDLINQMVSDFNSSQNEVEVVATFQGSYAEAAAKAEQAIFAGNAPDILQVAQDNVGRLAVNGAFADLLPHMQKDGMDDKDFVDAFVNDAYYEGKLVVIPFGRSAQILHINKTVLDEMGCEIPTTWEELKEVANKCTIVENGETKRYGLSVPFDQWEFFALIQQAGGKFFNEDQTGLGCLEDGTAKEAFSFMKDLQDSGALYYNDPANDQDNQMFTSGMAAMTINSSGAITSRRETIGDSFEYVVAPLVKGKIESMPTGGNGFGILAASKEQDAAWKFMKWFIEDEKGGLAFVIGSGYLPFTKTMAQSDAIQNLWKESDNYKIAYDALQYGDDSYRIANLTPVIAEFRTCIQAIMLDNQDIDQSLKTFSDSVDIILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGN2</accession>
    <name>F7KGN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254912.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05011"/>
    <dbReference type="EnsemblBacteria" id="EGN33806">
        <property type="protein sequence ID" value="EGN33806"/>
        <property type="gene ID" value="HMPREF0994_05011"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5474"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024500_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="633" mass="69145" checksum="FEF022A463651E97" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHW9</accession>
    <name>F7KHW9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32901.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360089.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05460"/>
    <dbReference type="EnsemblBacteria" id="EGN32901">
        <property type="protein sequence ID" value="EGN32901"/>
        <property type="gene ID" value="HMPREF0994_05460"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3981">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113231_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32901.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="19699" checksum="9BA75F5FBFBCD405" modified="2013-09-18" version="2">MLYLKKVNEQDAQEEYVYITNLPANENGFTNRYYGVSEEDFMQKVLPEMIDFSKGVGLPEGFVPETDFFLWEDNHIVGLFRIRHFLNDFLREGAGHIGYGIKKEYRGKGYASRGLAQALEEARRLVKEDEIYMSVNRDNPASLRVQEKNGAYIHHMDDKEYYTRIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI44</accession>
    <name>F7KI44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05474"/>
    <dbReference type="EnsemblBacteria" id="EGN32915">
        <property type="protein sequence ID" value="EGN32915"/>
        <property type="gene ID" value="HMPREF0994_05474"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5985"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_32_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="361" mass="41507" checksum="85740ED3B56BCF99" modified="2011-09-21" version="1">MILRKACFPLFIMIVFFRKSRSGKGMPQKAGYGILLTAESFFGRLKQDKQTDRAPAEEKSMTLQQLRYVIMTADCGSMNEAAKRLFISQPSLSGTIKELEEEIGLDIFLRSNRGIVITPEGEEFLGYARQVAEQYRLLTDKYLDKESKKKFSVSMQHYTFAVKAFVEMVKKVGMEQYEFAIHETKTHEVIENVRNFRSEIGILYLNDFNEQVMSKLLRENSLEFTELFQCDTYVYLWSGHPLAGEPVISMDQLEEYPCLAFDQGKNNSFYLAEEMKSTYEYKKIIKADDRATLLNLMVGLNAYTLCSGIICEELNGADYKAVPLAESEKMRIGYIRRKGAGISRIGRVYIEELLAYKDKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI84</accession>
    <name>F7KI84_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255370.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05563"/>
    <dbReference type="EnsemblBacteria" id="EGN32388">
        <property type="protein sequence ID" value="EGN32388"/>
        <property type="gene ID" value="HMPREF0994_05563"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808234_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="38770" checksum="5D256B311F01FA48" modified="2011-09-21" version="1">MENKEDKELLEKTIAVERLKAVPFFEDAPCYPAEQLVRLRNLGRQMEIDADNERRKGLLQEFCTLRDSLKRKGNAPKRIYLWPEGEMPVMTQYKDNYGCRYNHNPDFRPYLYEMLLPSDRKPKGAIVVCAGGDHGDCVVSEGYQTCLDFNKMGYHSFLLLNRPNRNPWTEQECGADTARAIRMVRAAAGSYGIRENQVAFAGFSNGGLTGEACIRYYSGAQRTTDHFPDYMEDDLDRYYGAPDAFLCIYGPRYKGAEFDYTDVVYPPVFFAVGREDTALDNLNAALPDLLAHGVEAEVHTFAGVPHGQGGITIMGENQYPNFQLWLQLADAFLQDVFQRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIC8</accession>
    <name>F7KIC8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255414.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05607"/>
    <dbReference type="EnsemblBacteria" id="EGN32318">
        <property type="protein sequence ID" value="EGN32318"/>
        <property type="gene ID" value="HMPREF0994_05607"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_17_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="126" mass="13875" checksum="AD1AA39E3CC7BAE8" modified="2011-09-21" version="1">MKRIMLQTYVSDATAAIELYKRAFGAKVLEIHHTPEGKVFHSELSIDGCILAVADREDGDGTSDITGNIMQFCLHFEPGKEDIVVKAYEVLSDKGSVHVPLGPSVFSSCMTDLTDCYGIRWCIFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ03</accession>
    <name>F7KJ03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05832"/>
    <dbReference type="EnsemblBacteria" id="EGN31460">
        <property type="protein sequence ID" value="EGN31460"/>
        <property type="gene ID" value="HMPREF0994_05832"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6382"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008033_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="606" mass="69571" checksum="1D97041435D198F0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ16</accession>
    <name>F7KJ16_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_05845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255621.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05845"/>
    <dbReference type="EnsemblBacteria" id="EGN31473">
        <property type="protein sequence ID" value="EGN31473"/>
        <property type="gene ID" value="HMPREF0994_05845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6396"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="63"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="380"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="413"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN31473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="619" mass="69179" checksum="8A893B3A987CD801" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJR2</accession>
    <name>F7KJR2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rubredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255854.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06078"/>
    <dbReference type="EnsemblBacteria" id="EGN31432">
        <property type="protein sequence ID" value="EGN31432"/>
        <property type="gene ID" value="HMPREF0994_06078"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6656"/>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023342_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="474" mass="50926" checksum="C10DF8B3222C15D1" modified="2011-09-21" version="1">MARYQCGICGYIFDEDAEEKEFSALEKCPVCGGSMDKFRLVEESGGQEAVREPAKPETAAPEAEESQDLSYPTEYRRMDGSVRYMDQIHEMAVTGQPIIEAMGTRMSMPGWDDILLLGAQLNPLPLDEHAFVDTTTVIGPNAKKPLVLSNPVYISHMSFGALSKEAKVSLAKGSALAHTAMCSGEGGILPEEREAAEKYIFEYVPNLYSVTSENLRRADAVEIKIGQGSKPGMGGHLPGGKVTPEIAALRNKPLGEDVISPSRFPGIATKEDLKALVDKLRAESDGRPIGIKIAAGRLERDLEYCVFAGPDFITIDGRGGATGASPRLVRDSTSVPTVFALYRARKYLDSVKSDISLVITGGLRVSSDFAKALAMGADAVAVASGALMAAACQQYRICGTGKCPIGMATQDETLRARLKVDAAAARVANYLNCSLAELKTFARITGHERLHDLNTGDLCTISREISEFTNIPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJY0</accession>
    <name>F7KJY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06169"/>
    <dbReference type="EnsemblBacteria" id="EGN30662">
        <property type="protein sequence ID" value="EGN30662"/>
        <property type="gene ID" value="HMPREF0994_06169"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219344_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="29" mass="3342" checksum="DAD62B52309A4ABA" modified="2011-09-21" version="1">MDILIWLIAATGIGMLIYYFVILLKGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKI2</accession>
    <name>F7KKI2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ORF">HMPREF0994_06361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256123.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06361"/>
    <dbReference type="EnsemblBacteria" id="EGN47969">
        <property type="protein sequence ID" value="EGN47969"/>
        <property type="gene ID" value="HMPREF0994_06361"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6964"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN47969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="169" mass="17851" checksum="007A41A4F844E739" modified="2011-09-21" version="1">MRHTIIDTNNLELTEKVVSIKRVTKVVKGGRNFRFTALVVVGDGAGHVGVGLGKATEIPEAIRKGKEDAAKNLIKVALDENNSITHDFLGKFGSATVLLKKAPDGTGVIAGGPVRNVCELAGIKNIRTKSLGSNNKQNVVLATIEGLSQLKTPEEVAANRGKSVDEIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKP5</accession>
    <name>F7KKP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256186.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06424"/>
    <dbReference type="EnsemblBacteria" id="EGN48032">
        <property type="protein sequence ID" value="EGN48032"/>
        <property type="gene ID" value="HMPREF0994_06424"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7034"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="950"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2004"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1977"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="985"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN48032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="2460" mass="275617" checksum="5FDBAFD0D23A83CC" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLE5</accession>
    <name>F7KLE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256427.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06674"/>
    <dbReference type="EnsemblBacteria" id="EGN46598">
        <property type="protein sequence ID" value="EGN46598"/>
        <property type="gene ID" value="HMPREF0994_06674"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7298"/>
    <dbReference type="eggNOG" id="COG2405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115769_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="164" mass="18292" checksum="6B6438EFCCF904C3" modified="2011-09-21" version="1">MIVVSDTTPLISLMKIGKLDLVANLFGEIQVPEAVYYELVSNTKFPAESKMIRESPFIKKVSVADIKAVELLRRSTGLDMGESEAIILSDQNSSDVLLMDEAKGRQVAKLMGINLMGTIGMLLVAYKEKYLSREEILKCIDILKNSGRHISNQLYEDLLRKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLL3</accession>
    <name>F7KLL3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ORF">HMPREF0994_06688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256441.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06688"/>
    <dbReference type="EnsemblBacteria" id="EGN46612">
        <property type="protein sequence ID" value="EGN46612"/>
        <property type="gene ID" value="HMPREF0994_06688"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7314"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN46612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="28374" checksum="FC9F5C122FF60683" modified="2011-09-21" version="1">MSIKYTLEGLEKKIGYVFRDKMLLRQALTHSSFANEQKINKLEDYERLEFLGDAVLELVSSEFLFSENPEMPEGKLTKLRSSMVCEPALAYCARDLELGQYMLLGKGEEATGGRGRDSITSDAMEAVIGALYLDGGFQAAHDFIHRFVLSDLENKILFYDSKTVLQEMIQTMPEAEFVYALTGEEGPDHDKEFLVDAVLNNRVIGKGKGRTKKAAEQQAAYEAILALRKNMEAEKSIEGIHSMEAKPSIENKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLU0</accession>
    <name>F7KLU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN46236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06819"/>
    <dbReference type="EnsemblBacteria" id="EGN46236">
        <property type="protein sequence ID" value="EGN46236"/>
        <property type="gene ID" value="HMPREF0994_06819"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7451"/>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040918_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="544" mass="61910" checksum="7F9C3586CA5AB510" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLY8</accession>
    <name>F7KLY8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06867</name>
        <name evidence="3" type="ORF">HMPREF0994_07012</name>
        <name evidence="4" type="ORF">HMPREF0994_07015</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256602.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN45075">
        <property type="protein sequence ID" value="EGN45075"/>
        <property type="gene ID" value="HMPREF0994_06867"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05344">
        <property type="protein sequence ID" value="EPC05344"/>
        <property type="gene ID" value="HMPREF0994_07012"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05347">
        <property type="protein sequence ID" value="EPC05347"/>
        <property type="gene ID" value="HMPREF0994_07015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7498"/>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046274_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="244"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN45075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="435" mass="50298" checksum="7E00094FB0CA0C87" modified="2011-09-21" version="1">MSKSIHTQKHMTLSDRIYIEQALSNHGSFKDIAAVLKKDPSTISKEIRKHRRPKDGSHYHLKNNCALLSSCNCSRICDGKLCNYLCKRSKSCDCTKHCPDFFPYLCPKLKKPPYVCNGCSNHACRHDKFFYRAKDAYTSYEQTKHECRQGINLTPEERAALDELVAPLILNGQTMDHIFTEHKEEIPCSERTLYRYIDSGILSVRNIDLPRKVKYKPRRQSDTSEKLTRECTIGRTYTDFLEYLEQYPETNVVEMDTVVGPEPGKVILTMLFRNCTFMLAFLMDNTKSESVINVFHFLQRELGTEVFSRLFPVILTDRGSEFSNPWAMECDEYGEILSKVFYCNANAPYQKGRLEKNHEFLRYIMPKGTSFDAMTQKYITLAVNHINSTARGSLNGRTPFELASMLLDEKLFKLLRLEPVEPDKVLLKPALLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS07</accession>
    <name>S2KS07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EPC05067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360282.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07288"/>
    <dbReference type="EnsemblBacteria" id="EPC05067">
        <property type="protein sequence ID" value="EPC05067"/>
        <property type="gene ID" value="HMPREF0994_07288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019175_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="655"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="754" mass="85756" checksum="1FB9D1C8BB0B5F20" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS61</accession>
    <name>S2KS61_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">HMPREF0994_07276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360264.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07276"/>
    <dbReference type="EnsemblBacteria" id="EPC05127">
        <property type="protein sequence ID" value="EPC05127"/>
        <property type="gene ID" value="HMPREF0994_07276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EPC05127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="210" mass="23677" checksum="20D05DB440A7DF7B" modified="2013-09-18" version="1">MKHRGILIVVSGFSGAGKGTLMKELISTYDNYALSVSMTTRKPRAGEEEGKSYFFVEKEAFEQTIAEDGLIEYACYCGNYYGTPREYVESCLDKGQDVILEIEIQGALKVKEKFPDALLLFIMPPSAKELRRRLEGRGTESDEVICQRISRAAEEAEGIENYEYIIINDKLDECVKEMHSIINAARRSPQRNKELIAGMRSELDALVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>S2L9Z3</accession>
    <name>S2L9Z3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360193.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07235"/>
    <dbReference type="ESTHER" id="9firm-s2l9z3">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05086">
        <property type="protein sequence ID" value="EPC05086"/>
        <property type="gene ID" value="HMPREF0994_07235"/>
    </dbReference>
    <dbReference type="GeneID" id="29729035"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="516" mass="57557" checksum="BE0D486E038136C6" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAM2</accession>
    <name>S2LAM2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antibiotic transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_07100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359955.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07100"/>
    <dbReference type="EnsemblBacteria" id="EPC05251">
        <property type="protein sequence ID" value="EPC05251"/>
        <property type="gene ID" value="HMPREF0994_07100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="336" mass="37951" checksum="5820BB8CE852F839" modified="2013-09-18" version="1">MIEVKNLTKYYGDKLAVDDVSFLVEEGEILGFLGPNGAGKSTTMNMLTGYLSASTGEIRINGIDMADNPGKAKRCIGYLPEIPPLYVDMTVEEYLRFMFRLKKVSRDVKREEHIDGICRQVKITEVKKRLIRNLSKGYKQRVGIAQAMLGDPPILILDEPTVGLDPNQIIEIRSLIRGLGKKHTVILSSHILPEIQAVCGRIIIINEGRIIADDTEENLSRRVGTAEGRKNRSQGPGIFRVLVEGPRREVTESLAAIHGIREVRFERRAEDEVFFYMLDTDGKTPVRRAIYDCISEHGWRLLGMESREMDLEDIFIKLTTGTYLEKKSNKGGDDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>S2LB04</accession>
    <name>S2LB04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359886.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07059"/>
    <dbReference type="EnsemblBacteria" id="EPC05391">
        <property type="protein sequence ID" value="EPC05391"/>
        <property type="gene ID" value="HMPREF0994_07059"/>
    </dbReference>
    <dbReference type="GeneID" id="29726631"/>
    <dbReference type="eggNOG" id="ENOG502Z7WG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017816_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="767" mass="87901" checksum="64C7FA72CC91ADA8" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJK3</accession>
    <name>S2LJK3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360137.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07198"/>
    <dbReference type="EnsemblBacteria" id="EPC05143">
        <property type="protein sequence ID" value="EPC05143"/>
        <property type="gene ID" value="HMPREF0994_07198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="194"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="34769" checksum="4A347F430189E2AC" modified="2013-09-18" version="1">MGTIRTRYMSGEDERQYMIGEDYEIYEKRGAPTGAVRLHYHDFYEVIYVMEGEFSSLVDNRTYNLKRGDFLLIGRNVMHNYHYVEGKHENSRRIVLWISEGMLEGLSEGEQDLCGCFSGRRDCAYHFPVHYEEILKNLLVKTAMTEIPDLEGAEGKRLFDKAQLILFFVYLNELCSRDSFYFTKEESIHHELVQRVNEYIEAHMSETILVEDLAGCVHMSKYYFLRRFKELTGMTVHSYLNNKRLMYSCEGLKEGMTIGEVWGKCGFSDYSSFLRNFRKEYGMSPTSYRAYLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJZ9</accession>
    <name>S2LJZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07102"/>
    <dbReference type="EnsemblBacteria" id="EPC05253">
        <property type="protein sequence ID" value="EPC05253"/>
        <property type="gene ID" value="HMPREF0994_07102"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="378" mass="44011" checksum="2B5D82A278A49F45" modified="2013-09-18" version="1">MNKDMENIVLIGPVYPYKGGISHYTGLMYRALSDKYKVTMVSYKFQYPKLLYKKEQRDYENDSFKIEDTNYWIHTANPVNWFTAANKIKKLNPDLVIIQWWHPYFAPCYWSMAKALGALKILFVCHNVFPHERFPMDKLLTRMVLKQGNYFIVQSGKDAEDLKGIMPDARYEQTVHPTYNAFKFENLSKEKSRELLGKSMHEKILLFFGFVREYKGLRYLIEAMPEISSRIADVKLMIVGDFGSEENKETYINLIKEKNVEKYIDICDGYIPDRDIEKFFAACDLVVLPYVDATQSGIVQIAYGFEKPVVVTNVGGLPDVVEDGKTGYVVEARRAKELAEAVICFFEGKKEAEFTDNVRKEAYRFSWERIVEVIEDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2E6</accession>
    <name>F7K2E6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00025"/>
    <dbReference type="EnsemblBacteria" id="EGN48258">
        <property type="protein sequence ID" value="EGN48258"/>
        <property type="gene ID" value="HMPREF0994_00025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.28"/>
    <dbReference type="eggNOG" id="ENOG5030QVY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151872_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="141" mass="15559" checksum="90E89A6E1506C445" modified="2011-09-21" version="1">MPDARLDLSAKRVNCHGFYTGFGTKPFSKEGCLITQKEVNAVFDGQVALCREILQKKTKEYTGGDTDRLGAFKAAAALQHTTPERALAGMLAKHIVSLYDMCFADGMSFDAGTWDEKITDSLNYLFLLKAIVKEGQTNQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2G2</accession>
    <name>F7K2G2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AbiEi_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249990.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00041"/>
    <dbReference type="EnsemblBacteria" id="EGN48274">
        <property type="protein sequence ID" value="EGN48274"/>
        <property type="gene ID" value="HMPREF0994_00041"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.44"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087902_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018547">
        <property type="entry name" value="AbiEi_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09407">
        <property type="entry name" value="AbiEi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiEi_1" evidence="1">
        <location>
            <begin position="70"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="29297" checksum="30BB2EC708BF3AFC" modified="2011-09-21" version="1">MERYKELAALRCFTHDDMVQLAGSESSAVWQIKSYLQKGYIERVRRNLYAVISMETGQAIPNRYQIASRVTDDACVSHHSAFEYYGYANQVFYDVYFTTQKRVRPFSYDGVNYCPMACRGNTDIIKTDTGIRVTSLERTVIDSIADFEKIGGLEELLRCLLLIPSLDYSKLLDALELYGRAQLYQKAGFILEAWKEELSLPEPFFVECEKRSSASKTYLFEKQGDFVLHNRWKLFAPKDLKTIINKGVTDYDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2G9</accession>
    <name>F7K2G9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_00048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249997.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00048"/>
    <dbReference type="EnsemblBacteria" id="EGN48281">
        <property type="protein sequence ID" value="EGN48281"/>
        <property type="gene ID" value="HMPREF0994_00048"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.51"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN48281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="594" mass="65705" checksum="3BEBDA7025EEAB4B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2K6</accession>
    <name>F7K2K6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250034.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00085"/>
    <dbReference type="EnsemblBacteria" id="EGN48318">
        <property type="protein sequence ID" value="EGN48318"/>
        <property type="gene ID" value="HMPREF0994_00085"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081840_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="204" mass="23576" checksum="F230DD4FFC146541" modified="2011-09-21" version="1">MELRLENEKDYFEVENLTREAFWDVYRPGCSEHLVLNKLRQADSFIKDLDYVLIEDGKIVGNIVYTKMFTGTERKMSDEVIAFGPISVHPDFQRKGLGKKLIEYTLDKAKCLGYKAVLITGDNNYYNPLGFESACRYHVYLPGTSEDDEAAFFMAKELEEGYLGNNSGIYDFDTCFNVSEEELEIFDRKFPEKSKREAKETDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2M7</accession>
    <name>F7K2M7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250055.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN42723">
        <property type="protein sequence ID" value="EGN42723"/>
        <property type="gene ID" value="HMPREF0994_00106"/>
    </dbReference>
    <dbReference type="GeneID" id="29726532"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.113"/>
    <dbReference type="eggNOG" id="COG1431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291297_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="138"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1012" mass="115664" checksum="E3CAAF7953F68EC6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Y2</accession>
    <name>F7K2Y2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TdcF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250160.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00211"/>
    <dbReference type="EnsemblBacteria" id="EGN39244">
        <property type="protein sequence ID" value="EGN39244"/>
        <property type="gene ID" value="HMPREF0994_00211"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.224"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="126" mass="13557" checksum="9F9A990F7A315807" modified="2011-09-21" version="1">MLKKIYTSNAPAAIGPYSQAILFNELLFSSGQIPVDPATGEVVQGDITVQAEQVMKNVGAVLKEAGTDFASVIKTTCFLSDMGDFAAFNEVYGKYFTEKPARSCVAVKTLPKNVLCEVEVIAEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K337</accession>
    <name>F7K337_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250215.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00266"/>
    <dbReference type="EnsemblBacteria" id="EGN37905">
        <property type="protein sequence ID" value="EGN37905"/>
        <property type="gene ID" value="HMPREF0994_00266"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN37905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="16764" checksum="C29C90AF78A16132" modified="2011-09-21" version="1">MFRYAHTNIIAKDSQRLIKFYKEVFRCESIGETRDLRGEWLDRLTGISNAHIVGEHLCLPGYEKDHPTLEIFSYDTMDNTSRVLNKCGIAHLAFEVDDVEMTLQLLLQNGGSQIGELVKTEYEDGKKAVFVYAADCEGNIVEIQSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K384</accession>
    <name>F7K384_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250262.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00313"/>
    <dbReference type="EnsemblBacteria" id="EGN33454">
        <property type="protein sequence ID" value="EGN33454"/>
        <property type="gene ID" value="HMPREF0994_00313"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.337"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="308" mass="34470" checksum="EA415E319C917BE1" modified="2011-09-21" version="1">MSTTAKSRKNPKNKVKLYHSLPDRILTASVWVLLIIIMIVILVPLMFILASSFSDPSAVSSGKVFLWPVDFSLVGYKAIFQSPSILRGFINSVEYTLVGTIISVTLTLFAGYPLSRVDLKIRGPVMFLFTVTMFFSGGMIPTYLVVSKLHLIDTFWAMVIPSAMGVWNVILTKTYIQSSIPLEIYESASIDGCSDWKYFTSMVFPLSKPIIAVMVLLYAVGKWNDFFSGLIYLNDSAKQPLQMTLRNILVMSDSFGINMNLAEQMNRQELKTLLQYSLIVVSSVPVLLLYPLIQKHFVKGIMMGSIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3K5</accession>
    <name>F7K3K5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00434"/>
    <dbReference type="EnsemblBacteria" id="EGN31949">
        <property type="protein sequence ID" value="EGN31949"/>
        <property type="gene ID" value="HMPREF0994_00434"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494161_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="405"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="551" mass="62878" checksum="01F13169DD31BF52" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3R4</accession>
    <name>F7K3R4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00493"/>
    <dbReference type="EnsemblBacteria" id="EGN48211">
        <property type="protein sequence ID" value="EGN48211"/>
        <property type="gene ID" value="HMPREF0994_00493"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.542"/>
    <dbReference type="eggNOG" id="ENOG502Z83H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228621_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN48211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="225" mass="24034" checksum="5FBFFFE4E657EA2E" modified="2011-09-21" version="1">MNLGVNPLLQFGLEETRKVLLENILSDLSVIRYVPFDSETIGNPALDLGDVLVFSGGHADETQTACVTGYQVKINGKHSLKCVGKNPRLAQAKSKNDKNISGLLNQIEAGKIGIHTFTNASAYSVSGTDVKIISIEFAAAEETHVQFFAIVLVDVAAEETVQGGTASGTVVVPVPSVAEDGTETTVDVSVEMELPVTVSADGKAIARVRYEFNDEEILIHYPTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3T9</accession>
    <name>F7K3T9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_00518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250467.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00518"/>
    <dbReference type="EnsemblBacteria" id="EGN45522">
        <property type="protein sequence ID" value="EGN45522"/>
        <property type="gene ID" value="HMPREF0994_00518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073546_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="10">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN45522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="302" mass="33453" checksum="874CF8B420816E33" modified="2011-09-21" version="1">MNFRNFIYLIRLGLKNVWNNKVYAAAAVMSMAACIFLFGIFYIAMVNINSAVRNVEKDVAVSVFFEEGISEERVEELGEEIRGREEVTNTVYISEDEAWDSFREDFLDSEELREGIFEGDNPLAGCDSYEVYINDISRQEEFVAYVKSLEGVGTVTHSSEVVNALIRLKERITGIGAGCLFVLILLSVLLIRSTLLVTVASQKDKVRVMRLIGAREDFIRIPFIVEGLVLGIAGMCIPIALLYATYVYGIRFVDVHFGLFGAPLKLLPAGQVMPELIQASVALGVLTGIIGSIAVMGRLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K460</accession>
    <name>F7K460_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250600.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00651"/>
    <dbReference type="EnsemblBacteria" id="EGN44839">
        <property type="protein sequence ID" value="EGN44839"/>
        <property type="gene ID" value="HMPREF0994_00651"/>
    </dbReference>
    <dbReference type="GeneID" id="29723737"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.707"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069103_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="40104" checksum="37EBB41EC1CF0C1E" modified="2011-09-21" version="1">MRIKEVIQKTGLSRRTIQFYISQKLITPKEDPVNGYHDFSDEDVRNLIIISRLRRLDFPVSDIRHILRFPGTASYYFYRQIDTLTKRIDTMRRNVDILARYFENNPAPIDCDSLAASLKLMESYEEKKAAADDFTELDKRIIPLFIWTPYLSGNRSEYQEFIWSKISRKVIEDYQPFLRSMKYIISALTPEQLTYSSKKTAQQAEKIASLKHDGLPVHAACMLEQIDAFLRNKALVEKWNLVYQPLIYPLLTIGYSEISSMMFELNSDYERFYNNICVLCGLIWNLLQTTESGKRIYERITDRLLPINWEQNGKGELERMTVFAFSPYALLEKDEITDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K479</accession>
    <name>F7K479_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250620.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00671"/>
    <dbReference type="EnsemblBacteria" id="EGN44859">
        <property type="protein sequence ID" value="EGN44859"/>
        <property type="gene ID" value="HMPREF0994_00671"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.727"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_13_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="126"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN44859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="362" mass="41622" checksum="2B0E8600A92CB8EB" modified="2011-09-21" version="1">MNLLDYIRDKIRFLCFFAFFILFLFCFLRITGYPAAYALLFLSLAAGLTLLYGGIDYCHKKTFFDHLLLQLDQLDKPYLIGEIMEKSPCLTDRLYRQVIRVSNRSVIENIHTLEKEKQEYREYIESWIHEVKAPLTSINLMCANQLSAQEEEGHFARKLLQETEAIENAVEQALYYARSDEVYRDFLITPCSLNDIVKESVTRCRRLLTACHMKVELHIPVSCTVYCDGIWLVFILSQLLRNSAQYKKGDCGKITITAKERPMQVLLTVRDEGTGIPDNELSRIFEKGFTGSNGRKTKSSTGMGLYLSKKLCQKLGLSIRAHSCEGVFTEILLEIPREENLPRFNGPDSGRQIFQNCKAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4C0</accession>
    <name>F7K4C0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_00699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250648.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00699"/>
    <dbReference type="EnsemblBacteria" id="EGN44048">
        <property type="protein sequence ID" value="EGN44048"/>
        <property type="gene ID" value="HMPREF0994_00699"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.758"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN44048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="228" mass="25965" checksum="AE660D02709F72DE" modified="2011-09-21" version="1">MKEEILIVEDDVDISGLLKRILEDAGYETKQAYSGTEALLCCEKKQPDLIMLDLMLPGMTGEEFLLTLREGGCDIPVLVLSARSSLQDKVTLLKEGADDYITKPFEPEEMTARVEAALRRRGHHEEKSGAKVYSYKDLKLYPEGRKVLVLDTLLSLTAYEYEILFLLIQNPEKVYSRELLYEQIWKGGYYGENNTVNVHVSNLRRKIKEAGAGDEYIRTVYGIGFKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4G4</accession>
    <name>F7K4G4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN44097">
        <property type="protein sequence ID" value="EGN44097"/>
        <property type="gene ID" value="HMPREF0994_00748"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.814"/>
    <dbReference type="HOGENOM" id="CLU_219678_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="39" mass="3974" checksum="BCFCDE44CB22B3B3" modified="2011-09-21" version="1">MEILLLMGGMLLIIIVAVVVAAVSSVVSAVAASEEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4G7</accession>
    <name>F7K4G7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripla_BP_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250702.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00753"/>
    <dbReference type="EnsemblBacteria" id="EGN44102">
        <property type="protein sequence ID" value="EGN44102"/>
        <property type="gene ID" value="HMPREF0994_00753"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.819"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="38"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="322" mass="35380" checksum="3055BAE0C4D16465" modified="2011-09-21" version="1">MKNNKKMFFLTETLLAVMVIAVAFIMVRERNGKEQDKISVIIQDSEDTQWAAFQYGLKMAAEDMDVRMFIVSTGSTLTVEEEKSLIEREIDNGADAVIVQPVPGSEEMLWKMGNRVPVMLIGNAASEEGEESLLPVVGPDNYALGAALAEELLKDYNGNLSGKTLGIFSKTGDSRASIERRRGFTDAMEHTDASISWSAAAPFSEEGEALLDSQSAVDLVIALDDNSLTMAGEYAAANNLHGALVYGIGNSTEAVYYLDTGIVGCLVVPDEFNVGYQSLKEAAESLTHYLHKMQDRTVSYNVIRRDNLFSRENQEIIFTMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4P8</accession>
    <name>F7K4P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250771.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00822"/>
    <dbReference type="EnsemblBacteria" id="EGN43531">
        <property type="protein sequence ID" value="EGN43531"/>
        <property type="gene ID" value="HMPREF0994_00822"/>
    </dbReference>
    <dbReference type="GeneID" id="29725304"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.896"/>
    <dbReference type="eggNOG" id="COG4099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035499_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041172">
        <property type="entry name" value="EstA_Ig-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18435">
        <property type="entry name" value="EstA_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EstA_Ig_like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="180"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="426" mass="47574" checksum="833555F959A33C02" modified="2011-09-21" version="1">MGRQYKTITEVFDFGPHISKVILHVGRSLKGAKLSDDQFRVSVKRTAMSGEDFAWPVFMGEKPDDSMKGTRRITDLYVSDAEGSCVEDGEYITLCMYCDPREGLGSIIRFDGNFNVTVNTAYKIVQLAPIETGADTLEGLVFDENGGNRFIYGELLQTAVHEDPEVSLAYCYYRPEEADAHKVPLLIWLHGAGEGGKEPLIAATGNKVVNLISPEIQKLFGGAYLLAPQAPTMWMDDGSGEYTKDGSSMYVEPLERLIADFVKEHEDIDTNRIYLGGDSNGGFMTMKMLIRNPGRYAAAFPVCEALDDSAITDKDIADIAQKPVWFTHSKDDPVVIPDKCVVPTYKRLIAAGGKNIHFTFWDHITDQTGQYFNEDGTPYTYIGHWAWIPMLNNQCKLDFDEQPVICGGRQAAVIDWIAQQRLEEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4W9</accession>
    <name>F7K4W9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250847.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00898"/>
    <dbReference type="EnsemblBacteria" id="EGN43207">
        <property type="protein sequence ID" value="EGN43207"/>
        <property type="gene ID" value="HMPREF0994_00898"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="461"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="584" mass="67973" checksum="7E7F6A1BB62D71A0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K519</accession>
    <name>F7K519_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250904.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00955"/>
    <dbReference type="EnsemblBacteria" id="EGN43264">
        <property type="protein sequence ID" value="EGN43264"/>
        <property type="gene ID" value="HMPREF0994_00955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="165" mass="18912" checksum="C71BBB768144CD8E" modified="2011-09-21" version="1">MRLRPYRKSDAKAIMNWIEDERTHALWCGNLLPFPFTEKDFNEYLEETEERWGNSSFTAVMDDGTPAGFLRMGINPALNSGFLGFVVVDAGERGKDCGKEMLRLAVKYAFEIASVQSLALNVFDCNKAAMGLYWNIGFEETALTPECFVFHDEKWGRCRMEIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5L1</accession>
    <name>F7K5L1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251092.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01143"/>
    <dbReference type="EnsemblBacteria" id="EGN42905">
        <property type="protein sequence ID" value="EGN42905"/>
        <property type="gene ID" value="HMPREF0994_01143"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="331"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN42905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="432" mass="49231" checksum="A9D721A5BB200A77" modified="2011-09-21" version="1">MNVLIVDDQKAIVESLREGIRWEELGVEKVYTACSAREAKLVLVNFPVDVMLSDIEMPEEDGLELCQWAKERLPALECIFLTSHADFSYAREAIRLGSFDYILQPVRYEEVEAVLRKAEGKIRENQSVRQLQNTRKLVVEQRDTILEAICMKLRQGREGDAEQILSTLKELLQPDFKKFSFYPAVVRIIKWKRIINTWDDKLVRLVIRNVLEELFAAAHGVTCIASMQDGSFVILAAVEDSLFDEEKWEVGLKEFYDFVEAQMDFSIAVYMGTKLPASEEESHGPAFGGMLTYLAGVGEELNPSGKSGIFKLADGAGEEAEGNEGEAEPVQKAVSYIKANLNKNISRTDVAELVHLNEEYFSRLFKQQTGETFKDYILLEKMNMARTLLERSNLSISIVASKVGYDNFSHFSKMFKKLTDMTPQEYRKEHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5M9</accession>
    <name>F7K5M9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251114.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01165"/>
    <dbReference type="EnsemblBacteria" id="EGN42927">
        <property type="protein sequence ID" value="EGN42927"/>
        <property type="gene ID" value="HMPREF0994_01165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1275"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN42927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="375" mass="43343" checksum="314F6778228FC8BF" modified="2011-09-21" version="1">MARKGENIYKRKDGRWEGRYRIPNPSGTKALYRSVYGKSYREVREKLFAGKQIVLRKAGKKSQLPDKMTLGEAAGLWLEENRSKWKESTYATYRSITEKHVLPLWGTQTADALLIDPPVSLPGLKEGEQKKYSGAYKHQIQIITSQIFHFLDKKYHCGVPQWLSPAAPAQNRTITPPEGDKLRRLEAYLSYKAEEKDATSIGILLSGCCGLRIGELCALQWKNINWEEGTIQIRGTMQRIRTFQQEDKKTKIIISDPKSRSSNREIPVPAYLLDYLKRLKGNREGYILAGKKKEYLEPRTLQYRFKKILEQLGIPYFNFHMLRHIFATNCISRGFDMKTLSELLGHSNITTTMRIYVHSDMERKKQLMAGYRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5S0</accession>
    <name>F7K5S0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251148.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01199"/>
    <dbReference type="EnsemblBacteria" id="EGN42600">
        <property type="protein sequence ID" value="EGN42600"/>
        <property type="gene ID" value="HMPREF0994_01199"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1312"/>
    <dbReference type="eggNOG" id="ENOG502ZBBN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833631_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="333" mass="38609" checksum="14FEFBD213C66ED2" modified="2011-09-21" version="1">MKKKQLRLLLPLCILLLCCLAGILCFFRSRAQDTFLQLSELNDAAKEEKDTAVNPYFDLSVPTYITRLQDTYFLVDCYHDEIIYSDSLSRPLNEWDVMTDEISRGHTIASDGEVYLADDTENHRILVFEKEDGKFLHTQTFSDIGVRPHYIVYDEKTRCFYVLSSMTGELYVFTREKDSTRMALKDVRSIEKLNGIYVRSFTIMGDEIYFVSGNSTIIRARLKDLKILEEYPVPPEIAGMVQLTKIQDYFYITVSTDADFNQDYATFIRTKDLHSLAGGDYEDVYSYFIGGGTPYYITSFDGHYYLTEHRLPGHSVWQFDVEDNEIVNVIPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5U5</accession>
    <name>F7K5U5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251173.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01224"/>
    <dbReference type="EnsemblBacteria" id="EGN42550">
        <property type="protein sequence ID" value="EGN42550"/>
        <property type="gene ID" value="HMPREF0994_01224"/>
    </dbReference>
    <dbReference type="GeneID" id="29726375"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1337"/>
    <dbReference type="eggNOG" id="ENOG5033HYI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151197_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="107" mass="12395" checksum="38A258FBF460676A" modified="2011-09-21" version="1">MEKAVDEVISRLAEIEDTANRMNDAVEVRKKEISAEMEARTKDFDEALSADTNKKLEELQNRLMKEKEEELAGLEEETGQLLEKLQQKYDKEHGKLSDRLLNEMVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K661</accession>
    <name>F7K661_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251290.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01341"/>
    <dbReference type="EnsemblBacteria" id="EGN42203">
        <property type="protein sequence ID" value="EGN42203"/>
        <property type="gene ID" value="HMPREF0994_01341"/>
    </dbReference>
    <dbReference type="GeneID" id="29723485"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_4_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="316" mass="37125" checksum="24FDA421F8741189" modified="2011-09-21" version="1">MNQCGKEQIILSVCIVTYNHEKYIKQCIDSILQQKVEFPIEILIGNDCSTDNTACILAEEYGNNVVLINRDKNIGLCANMYDLFLRAKGKYVYLFSGDDFLYKNYVFSRQVEFLEKNPEYFSVSARNLIYKQRINSYQDASGSVGEYSVYNYLLGGGVPSVIGTMKNVFVQDKEFNAFLKEGARNNEEMKLWLYTLDKGKKYIIDEPMSVYRAVTEYEDNYNSTHTIIDKVHDYAMDYRVVNRIYGNKYNVRPYYLQLLNRYCVYMSYSMKDIVSFYKNLSIKDTISLVMYKMYLKTHGYENPLKWIKEDYLIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6F1</accession>
    <name>F7K6F1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251405.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01456"/>
    <dbReference type="EnsemblBacteria" id="EGN41930">
        <property type="protein sequence ID" value="EGN41930"/>
        <property type="gene ID" value="HMPREF0994_01456"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1587"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="39909" checksum="F43C597800D6FADE" modified="2011-09-21" version="1">MKLSVIVPVYNTAGEGKLEYCLNSLVNQTCRDMEIIAVDDCSTDNSWEILRRYEAEYPDRFRAVHSQVNRKQGGAKNIGLSMAGGEWIGFIDSDDWITPDMYEVMLARAEETGADMVGCDYCLTHEHSMKVGQVVPNNKPSQAGVLDHEKYASLILDSGSLVVKIYRREIILGCDSRFPEGIFYEDNALGNTWMLRAKNFSYIPKAMYYYYQHEESTVHTITRKRCEDRMEAGRIMIAEAKKYGYLEEYYKELECSFAVLFYANTLFTYMFGVKKKELSFVKALGKEMRDTFPEFQDNPYYLERFNEEEKKLVRMQQKSSLVFMLYFTLLWTYRNFRKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6H4</accession>
    <name>F7K6H4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41956.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360003.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01482"/>
    <dbReference type="EnsemblBacteria" id="EGN41956">
        <property type="protein sequence ID" value="EGN41956"/>
        <property type="gene ID" value="HMPREF0994_01482"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="76"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41956.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="306" mass="34246" checksum="E8D0F7963C6C4DE5" modified="2013-09-18" version="2">MDQYNIHPDFLKYKITPPLNPAFLPAVQFFMKRMQDMVKIPEGLKETRRKIPGYQDAPVGISIFEPEKGREPLPALVYFHGGAFALQSAPCHKKLSCSYALNTPCKVVSVDYRLLPENTFPIGLEDCFAAYRWVLENAAQLGISPNRIAVGGDSAGGALSAGVCLLARDRGIPVPCFQMLIYPVMDERQNSASMKKYNDTPLWNSRLNAKMWKMYLKDGLPVEKGYASPAEAVSLEGMPPAYVEVAEYDCLRDEGIAFAKSLKDSGIPAELYETKRTVHGFEIAEKNEIVKESVDRRIKKLRSVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K795</accession>
    <name>F7K795_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251637.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01724"/>
    <dbReference type="EnsemblBacteria" id="EGN41667">
        <property type="protein sequence ID" value="EGN41667"/>
        <property type="gene ID" value="HMPREF0994_01724"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1882"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="33741" checksum="D4149B661A8D4EDE" modified="2011-09-21" version="1">MAASGKSKKKMSLNRRNTLVGLSFILPNFIGFFIFVMIPVAFSLMLSFADWDGFNPMKFAGLDNFVAIFKDRVFRGSIWKTLYFSAFTVFFSMCASLGLAILLNQRLKGKGIFRCAIFFPYVASTVAVAAVWNSLFRDIGPINSILRALGVANPPGWTASTAWVIPALIIVNIWKNMGYFMIVYLAALQDIPESLYEAARIDGANSMQCFRGITLPMLTPSTFFVVMMLTINSFKVFDLVYLMTEGGPGNASTMMSQYIYNRAFIAWNYGESSAAAMILFLILGLLTILQFRMEKKWVSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7G6</accession>
    <name>F7K7G6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251708.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01795"/>
    <dbReference type="EnsemblBacteria" id="EGN41608">
        <property type="protein sequence ID" value="EGN41608"/>
        <property type="gene ID" value="HMPREF0994_01795"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1959"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333644_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="462"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="714"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="745"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="866" mass="93580" checksum="96A8ABB311CB9254" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7J9</accession>
    <name>F7K7J9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sporulation integral membrane protein YtvI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251741.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01828"/>
    <dbReference type="EnsemblBacteria" id="EGN41641">
        <property type="protein sequence ID" value="EGN41641"/>
        <property type="gene ID" value="HMPREF0994_01828"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2000"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014227">
        <property type="entry name" value="YtvI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02872">
        <property type="entry name" value="spore_ytvI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="365" mass="39617" checksum="07D0118F13655385" modified="2011-09-21" version="1">MSEEKMKKFIIRVLFWSLAGGLVFLTAGYILPVLKPFIAAFVIAIILNPIIRFFTKKGRCGRKAASVTTLILFYTILFLFIAVVGADFVSFIKTSVVRFPELYDNTILPALELAAHGMEAAAEHFSPDFQTMLAYIGESVSGAISGFAGNVSSSVVALVTGIASKTPQTLMNFIITIVASFFCIIDYEKIITFAGRHLPPKAKQVFSRIKEKGISVLQQFGKAYLILMGLTFVELAVGLFLLKVDDSILLAGLIALVDILPVLGVGTVLLPWIAISFLTDNIPLGVGLLILYIIITVVRQILEPRVVGQQIGLHPLITMMCMFVGACFFGIIGLFGFPVLATVLVQLKRTGGFDNADNGGEVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7P8</accession>
    <name>F7K7P8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251855.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01942"/>
    <dbReference type="EnsemblBacteria" id="EGN41347">
        <property type="protein sequence ID" value="EGN41347"/>
        <property type="gene ID" value="HMPREF0994_01942"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="158"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="269" mass="30953" checksum="62116FEBF168B218" modified="2011-09-21" version="1">MIKVLVADDERWIRKGIVRMIDRERNPIGEIWEAENVTQALEIFRREMPEIILSDVMFPQENGCDLGERIFEMNPNAKIVMISAYDDFDNARRALRFRAVDYLLKPVSREQLNLILDQCVQQIEAERQQAEGEKAGADVLEERLAVMAEDNSSSRIVEKLMRDIREDCARHYTLSQLAEECHVTESYFSSLFKKVSGKSLMSYLAQVRVEKAQELIASTEYKLVQIAEAVGYDDYQYFTKVFKKISGVTPGEYKAGIAREIEDEDGTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7X3</accession>
    <name>F7K7X3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251932.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02019"/>
    <dbReference type="EnsemblBacteria" id="EGN41424">
        <property type="protein sequence ID" value="EGN41424"/>
        <property type="gene ID" value="HMPREF0994_02019"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2216"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN41424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="531" mass="61559" checksum="49AEA7C55A57BDF4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K878</accession>
    <name>F7K878_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_Apea domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251764.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01851"/>
    <dbReference type="EnsemblBacteria" id="EGN41256">
        <property type="protein sequence ID" value="EGN41256"/>
        <property type="gene ID" value="HMPREF0994_01851"/>
    </dbReference>
    <dbReference type="GeneID" id="29728035"/>
    <dbReference type="eggNOG" id="ENOG5030B8A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538304_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041229">
        <property type="entry name" value="HEPN_Apea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18739">
        <property type="entry name" value="HEPN_Apea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_Apea" evidence="1">
        <location>
            <begin position="338"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="489" mass="56721" checksum="44B28FF6A4D2AB84" modified="2011-09-21" version="1">MDTLENDLMDELRELVKVVVKNLLINIKKYMDANKLIMSNVDYPTSAKRDDSTKWPEVHKTNLLSGILQSDYEYRDYSSVITLHKNEDKILIDEVCGFSELLDFIISNETISKRLWYEGNIEKDRNRIALFLIIGDIVDRYISIYGGTEYSIEKFNSIYDEVTNIYFLKQLEFDICIPILMIEFESDNIEISDVISIEKMPLEFIRSKANIGNYDSHFENIVINCATHMIVIKGYTLENKSFRSTEIFENKSAYPIQVIDAIFASIRTISKYSTGYAQFVCRPQNNWINRNCKGDLMGLTGAKAKEFPEEFIDFSWLKQHLIIKKDLEAHIVDLANRLIDNSNNVLDLAIKRLNRSVLRDNEEDTILDAIIGLELLLSDNDKGELTYKISSRMATISTLIDDFPYTPMQVQKSMSQIYRYRSDIVHSRKIRPATKLIIIDDKTEITPIVLAIDYLRYAINILAHNPEYLNSKNIDKLMMERIHEGLNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8G6</accession>
    <name>F7K8G6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_02146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252059.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02146"/>
    <dbReference type="EnsemblBacteria" id="EGN41053">
        <property type="protein sequence ID" value="EGN41053"/>
        <property type="gene ID" value="HMPREF0994_02146"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2349"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="391"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="459"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="528"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="703" mass="76436" checksum="B4725E95C463F630" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8Q6</accession>
    <name>F7K8Q6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN41158">
        <property type="protein sequence ID" value="EGN41158"/>
        <property type="gene ID" value="HMPREF0994_02251"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2459"/>
    <dbReference type="HOGENOM" id="CLU_2954650_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="59" mass="6628" checksum="EA38E6986CE68DCF" modified="2011-09-21" version="1">MLTEQMKQAQGITEQLKAENALEWTGCKNSVCFCMKSKFLSCLTFGKLSVTISMTEIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8R0</accession>
    <name>F7K8R0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252157.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02256"/>
    <dbReference type="EnsemblBacteria" id="EGN41163">
        <property type="protein sequence ID" value="EGN41163"/>
        <property type="gene ID" value="HMPREF0994_02256"/>
    </dbReference>
    <dbReference type="GeneID" id="29723492"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2479361_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="10205" checksum="F9173C4C7B7B4D69" modified="2011-09-21" version="1">MSSIIPGFLKEFEVADVIKEIAPRHFLIVCADEDKYSKDAPQIFESVKEHYISKNAESNLYMKQYKGGHQLTQERFDYILKWIISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K943</accession>
    <name>F7K943_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252282.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02381"/>
    <dbReference type="EnsemblBacteria" id="EGN40780">
        <property type="protein sequence ID" value="EGN40780"/>
        <property type="gene ID" value="HMPREF0994_02381"/>
    </dbReference>
    <dbReference type="GeneID" id="29723493"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084986_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="256" mass="30807" checksum="3A57472C930A7CB1" modified="2011-09-21" version="1">MNWLRIAQGVLCAVEVCGLYYIFNLFYEQKRDKLWERISFIITLILFCGLTIFQREVGGMYSRYFMFLCIFLAVCIGKFFYNITFTRCLLVSTLYFESIYFSDIFLGYIGQALLDSIDFVDYIQFQINLERIIILGITRCFLLIVLFILRKYKIHVNNLCFNYRMLLIGFAVLEYLGLFSCEKVFIPAYREEGKIYVYFALFPIILILTFIIVIVYIMYIEKKNEMQLMNSQNEMLEKIIMKCYYYIRKEIEFFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9B4</accession>
    <name>F7K9B4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02463"/>
    <dbReference type="EnsemblBacteria" id="EGN40862">
        <property type="protein sequence ID" value="EGN40862"/>
        <property type="gene ID" value="HMPREF0994_02463"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2701"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068870_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="282" mass="31741" checksum="D9F39FF6DB98131A" modified="2011-09-21" version="1">MSAGKRCKLKLHQYNTNIFDEFRIKCNKCSGLCCTALYFSKYDGFPADKAAGIPCSYLDDCFRCSIHKELHSRHMKGCLAYDCCGAGQTVTSLYGDENWKSNPPIAQEVFDVFVKTYYLQQILWYMSEVLTLLPAKSLWAEADSCIKELHLLLKSTPQNILDFDMEVCRTKVNALLNKAWIMVKQQVGNPKDIAGKKDFMGHNFKKSRLNGCDFSSALLIAANLEECDLTGCNFLGADMRDTNIQNADLSESIFLTQGQINAAKGNLNTRIPGHLIRPSEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9B5</accession>
    <name>F7K9B5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252365.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02464"/>
    <dbReference type="EnsemblBacteria" id="EGN40863">
        <property type="protein sequence ID" value="EGN40863"/>
        <property type="gene ID" value="HMPREF0994_02464"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2702"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031277_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="413" mass="47270" checksum="4AF0FF5E0E342D47" modified="2011-09-21" version="1">MAEIRPFRAYRPKKGLEQRIAALPYDVYNREEAKAEVKKEPLSFLAVDRAETQFDDSVDVYADCVYEKAREMLWKRIEEGSFEQEETPVYYIYELVMDGRAQTGITACASVDDYLNQVIKKHENTRADKEADRIRHVDICDAQTGPIFLAYRSQPVINAIVAQYKAGEPLYDFISPDGIAHRVWKIDGPEDVDAVHRAFSEVGEIYIADGHHRCASAVKVSEKRRQERPGYTGEEEFNFFLSVLFPDDQLMIMDYNRVVKDLNDLTKEEFIGKIRESFQIEELQTGADGRPDKKGTFGMYLDGSWYRLTAKENILSKDPVKGLDVSVLQDYLLEPVLGIKDPKTDKRIDFVGGIRGMKELERRVSEDCRIAFAMYPTSIGELFAVADAGLLMPPKSTWFEPKLRSGLFIHSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9C3</accession>
    <name>F7K9C3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02474"/>
    <dbReference type="EnsemblBacteria" id="EGN40873">
        <property type="protein sequence ID" value="EGN40873"/>
        <property type="gene ID" value="HMPREF0994_02474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_101_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="143" mass="16040" checksum="8491794CC2131EAB" modified="2011-09-21" version="1">MRIIVMNMEDGDEELLLELMDSVSVHEGKIEVISSAAVPSVSFKGLTINCGKRQVFREDKEIRLTRLEYDVLYLLAAHAGQIVSKELIFKAVWGSASEDTIKVVANTVSNLRGKMEPNRHCPIYIKTVFGGYLFCDEMITDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9C6</accession>
    <name>F7K9C6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02477"/>
    <dbReference type="EnsemblBacteria" id="EGN40876">
        <property type="protein sequence ID" value="EGN40876"/>
        <property type="gene ID" value="HMPREF0994_02477"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50315B6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3062699_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="53" mass="6311" checksum="20B149663E4BE275" modified="2011-09-21" version="1">MHKEYMLSCFNLNKMEDEEDFFESIDEMKSYIEQGGENIIVEGTYHLDEISID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9I9</accession>
    <name>F7K9I9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252453.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02552"/>
    <dbReference type="EnsemblBacteria" id="EGN40951">
        <property type="protein sequence ID" value="EGN40951"/>
        <property type="gene ID" value="HMPREF0994_02552"/>
    </dbReference>
    <dbReference type="GeneID" id="29725028"/>
    <dbReference type="eggNOG" id="COG4767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042608_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="6">
        <location>
            <begin position="48"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="208"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="362" mass="41418" checksum="BA3FA86766C0B6D5" modified="2011-09-21" version="1">MSVYINPIANGITVSLMIIYLAFIPVLIYQYRKNGTFLVRKNIVLASFAVYMITAFFMTLLPLPSIEAVKNMAPVRANYHPFLFVKTFLNESGFIWNEMGTWFRAFCSPSFYTVAFNVLLTLPFGVYLRKYFNKGLFQTAVLGFLLSFFYEATQYTGVWWIYPHAFRYPDVDDLIVNTLGTVVGFYAAGLLDKLLPDPMKDKSLKTEYASLLRRLISLLIDSIFVNIVYELLRVVVLLAAGKKENTIDIVLYLISVVIIFILIPCISKKKRTFGMTILKLALRDGKGNVPRLSGMIMHNLFIAFWLNVAVNIIGMIDNAWIIIFLQLAVLGFAAALLIISIKNKRVTYFWEKFFDTYMKADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9M7</accession>
    <name>F7K9M7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02467"/>
    <dbReference type="EnsemblBacteria" id="EGN40866">
        <property type="protein sequence ID" value="EGN40866"/>
        <property type="gene ID" value="HMPREF0994_02467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114424_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="18708" checksum="B83E4F4184F81234" modified="2011-09-21" version="1">MVKPIREEELFESLEIFHRGYETVAAEFGLTEENCPDRGRASLPYHKLLSEFESGILMYGYFDGDKLTGFLGMKILEDSSKLEDLIILPEYRKLGYGSCLLDYCKKKTLELGLRKVVLGMIDDNVRLRNWYIKNGFVNTGYKKYENAPFTVGYMEWNSQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9N7</accession>
    <name>F7K9N7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252417.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02516"/>
    <dbReference type="EnsemblBacteria" id="EGN40915">
        <property type="protein sequence ID" value="EGN40915"/>
        <property type="gene ID" value="HMPREF0994_02516"/>
    </dbReference>
    <dbReference type="GeneID" id="29724629"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2758"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="297" mass="33779" checksum="881988FA12C32CA1" modified="2011-09-21" version="1">MEDFQSVIVSEDKMELRVHGTAGFPCGCYSGNPSLGYTPWHWHEEYEAGVVIRGSTQLSAGRKTFLMQEGDGIFINSGVLHTLAPVRTAPASEKRDLVFHGRLLYGTTDSVLWQKYLRPVTSCQELDAILFRPSVPWQKEAIGQILLAQQLLSERREGYEFMVREALSRMIFLVYENCKASLTGAFSETSLEMQRLKIMLEYIRLHYQEPVTLKEIASSANICEREALRSFRKIIRQSPVQYLIHYRISRACLILKSGEKNITEICSCCGFSSPSYFTKTFKKITGCTPREYAGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Z6</accession>
    <name>F7K9Z6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252580.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02679"/>
    <dbReference type="EnsemblBacteria" id="EGN40662">
        <property type="protein sequence ID" value="EGN40662"/>
        <property type="gene ID" value="HMPREF0994_02679"/>
    </dbReference>
    <dbReference type="GeneID" id="29725609"/>
    <dbReference type="HOGENOM" id="CLU_2916691_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="61" mass="6874" checksum="F5637CE209679A6C" modified="2011-09-21" version="1">MEHKKTNILFILTDDQGAWAMGCAGNTDTDVLKENGKVTFSSQYITNVITDKALSYLEEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA22</accession>
    <name>F7KA22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252606.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02705"/>
    <dbReference type="EnsemblBacteria" id="EGN40688">
        <property type="protein sequence ID" value="EGN40688"/>
        <property type="gene ID" value="HMPREF0994_02705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2960"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="261" mass="28669" checksum="1B8538FAA6457A1F" modified="2011-09-21" version="1">MDAVLTGKGISVAYQQNIIIPSMNVEIPRGCVTSVIGPNGCGKSTLLKALSRMLPVRSGQVLLDGGMIARMPAAEVAKQMAILPQGPQAPGGLTVAELVAYGRYPHQKGFGRLRKEDYKAIDRALEMTHMEEFAERDIDALSGGQRQRAWIAMALAQDTQVILLDEPTTYLDMAHQLEVLKLLEKLNKTRGKTIALVIHDLNLAARFSDRMIAMREGKVLHEGTPEEIMTPTVLEEVFSLKACISKDPWTGRPTCVTYEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA91</accession>
    <name>F7KA91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0994_02941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252842.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02941"/>
    <dbReference type="EnsemblBacteria" id="EGN40550">
        <property type="protein sequence ID" value="EGN40550"/>
        <property type="gene ID" value="HMPREF0994_02941"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3209"/>
    <dbReference type="eggNOG" id="COG0538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="9"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="307"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN40550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="402" mass="45441" checksum="DABD96910E19F9E9" modified="2011-09-21" version="1">MNKIAMNTPLVEMDGDEMTRILWKMIKDELLLPFVDLKTEYYDLGLEHRNETNDQVTVDSAEATKKYGVAVKCATITPNGARMSEYNLKEMWKSPNGTIRSILDGTVFRAPIVVKGIEPCVRNWEKPITIARHAYGDVYKNVEMKIEGAGKAELVFTDKDGNVSRETIHDFKDAGIIQGVHNTKASITSFARACFQYAVSTKQDLWFGTKDTISKKYDHTFKDIFQEVYEQEYKEKFDELGLEYFYSLIDDIVARIMKAKGGFIWACKNYDGDVMSDMVSSAFGSLAMMTSVLVSPEGIYEYEAAHGTVQRHYYKYLKGEETSTNPVATIFAWTGALRKRGELDAIPELEKFADKLEKATLATIENGVMTKDLAQITTLRDVTVLNSQDFIGAIRKQLEAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAI3</accession>
    <name>F7KAI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252710.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02809"/>
    <dbReference type="EnsemblBacteria" id="EGN40418">
        <property type="protein sequence ID" value="EGN40418"/>
        <property type="gene ID" value="HMPREF0994_02809"/>
    </dbReference>
    <dbReference type="GeneID" id="29724175"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3075"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259913_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1320" mass="150222" checksum="7C8484E217B87D11" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAS8</accession>
    <name>F7KAS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02909"/>
    <dbReference type="EnsemblBacteria" id="EGN40518">
        <property type="protein sequence ID" value="EGN40518"/>
        <property type="gene ID" value="HMPREF0994_02909"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164680_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="100" mass="11589" checksum="AEC66E6268FB38B9" modified="2011-09-21" version="1">MQYRQLGYSKKFLAAHESDIALHKAVKQAFNKLELEKLPSMDAVKTEYATLLSQKNKLYGEYKQARQKMGDLQMAKYNIDRILNVQQPAETTKSIAHDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAT5</accession>
    <name>F7KAT5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_02964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252865.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02964"/>
    <dbReference type="EnsemblBacteria" id="EGN40342">
        <property type="protein sequence ID" value="EGN40342"/>
        <property type="gene ID" value="HMPREF0994_02964"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3235"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_2_1_9"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="306"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="376" mass="41359" checksum="B3579791B1EA294C" modified="2011-09-21" version="1">MEQLTFSFFGLGLIGGSIARAIRASHPDCFIRACDTDSSTLRLALEEGVIDEASERIDEENGMAFTDCDFLFLCAPVSQNDSNLRLIRKFLLSEGRTHSNCILTDVGSVKSTIHASIEELGLTSCFIGGHPMAGSERIGFQNSKASLLENAYYILTPTPDVSGEQAERYAALVKAMGAIPLILDYRQHDYVTAAISHLPHVIASSLVNLVKASDNEDGIMKLVAAGGFKDITRIASSSTVMWQQICLTNKENISQLLERYISSLEKVKDEIDRSDAAQLYHFFDTARSYRDSFIDASSGPIKRVYTINVEIPDEAGSLASVATLLALNHISIKNIGIVHNRESEDGVLRIEFYEEASIEKAEKLLGSRGYMVFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB49</accession>
    <name>F7KB49_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iscS</name>
        <name evidence="10" type="ORF">HMPREF0994_03080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252981.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03080"/>
    <dbReference type="EnsemblBacteria" id="EGN40257">
        <property type="protein sequence ID" value="EGN40257"/>
        <property type="gene ID" value="HMPREF0994_03080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3366"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="5"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="395" mass="43642" checksum="9DBD2E9A7A327CB4" modified="2011-09-21" version="1">MSRIIYLDNAATTKTAPEVVQAMLPYFTENYGNPSSIYSLGTESKKAISQVRETIAGTLGAANNEIYFTAGGSEADNWALKAVAEAYASKGKHIITSKIEHHAVLHTCEYLEKNGCEITYVNVDENGIVKLDELEKAIRPDTILISIMYANNEIGTIQPIKEIGEIARKHNVLFHTDAVQAYGQLPINVDECSIDMLSASGHKLNGPKGIGFLYIRKGIKIRSFIHGGQQERGRRAGTENVPGIVGLGAAVERAFSMMEEKTVKERELQDYLIGRIESEIPYCRLNGDREKRLPNNVNFSFRFVEGESLLIMLDMKGICASSGSACTSGSLDPSHVLLAIGLPHEIAHGSLRMSLNEENTKEELDFTVEAIKEIVTKLRDMSPLYEDFVKKNKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBJ6</accession>
    <name>F7KBJ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03232"/>
    <dbReference type="EnsemblBacteria" id="EGN40062">
        <property type="protein sequence ID" value="EGN40062"/>
        <property type="gene ID" value="HMPREF0994_03232"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCMI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1776023_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="18459" checksum="5E55050901C85448" modified="2011-09-21" version="1">MGEKMKKAGKVMGIIIMSLLPGIIALYFLLSFIIAPAVNDHIAKKLYKEMVQVPLPEGAVVCDSRFLAGNLVGNGNKMQYFAALLLRSEWTMEELEDYYLPYREDKWHFIVERQEGTGIGPLEGREEFSIPGEKKKDEKYYIVYSWGSSGFPFQDWDLRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC03</accession>
    <name>F7KC03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-3B C17-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253283.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03382"/>
    <dbReference type="EnsemblBacteria" id="EGN39889">
        <property type="protein sequence ID" value="EGN39889"/>
        <property type="gene ID" value="HMPREF0994_03382"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3696"/>
    <dbReference type="eggNOG" id="COG1010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047948_2_0_9"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="27615" checksum="B651B8324B3C1972" modified="2011-09-21" version="1">MLYIVGFGPGSYEQMTVEADRALQESDLIIGYTTYVDIIRPWFPGKEFLVTPMKQEKERCRIAIEEEKKGKKVSLVCSGDSGIYGMASLVYELAEQEEGFAERIHVIAGVTAAASGGALLGAPLSHDFLTVSLSDLLTPMEVIQDRIRSGAESDTVLCIYNPSSRKRGDYLRMACDIVLEKRSGQTVCGYVQNIGREGEKAVVTTLEELRDTQVDMFTTVFIGNSHTRNIHGKMVTPRGYRLETEKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC71</accession>
    <name>F7KC71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253351.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03450"/>
    <dbReference type="EnsemblBacteria" id="EGN39523">
        <property type="protein sequence ID" value="EGN39523"/>
        <property type="gene ID" value="HMPREF0994_03450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3769"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN39523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="36108" checksum="90967887F46EBAE6" modified="2011-09-21" version="1">MKVDRLVSIIMILLDKKRIGAQELADMFEVSPRTIYRDIDAINMAGIPVRSTSGVGGGFEIMEKYKIDRKVFSTDDLSALLMGLSSLSNMIRGDELVHALAKVKSFIPADKAKDIEFRANQVYIDLDPWMGNSNTHPYLETIKTALQESRLLSFEYADRYGKKTTRTAEPYQLVLKSSHWYWLGYCHKRNDFRLFRISRISNLQIQDETFTPRDYPNPQLDFTDIAAAMQTKIKIRIHKSVMERALDFCTYENFSPDGDDHYIVSFPFIENDYYYNILFSFGDKCECLEPEHIRTEMLRRIHDIAALYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCD5</accession>
    <name>F7KCD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253415.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03514"/>
    <dbReference type="EnsemblBacteria" id="EGN39423">
        <property type="protein sequence ID" value="EGN39423"/>
        <property type="gene ID" value="HMPREF0994_03514"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3841"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010402_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033396">
        <property type="entry name" value="DUF5107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17128">
        <property type="entry name" value="DUF5107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1092" mass="125197" checksum="D85FDF267C5C1964" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCL4</accession>
    <name>F7KCL4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03600"/>
    <dbReference type="EnsemblBacteria" id="EGN39509">
        <property type="protein sequence ID" value="EGN39509"/>
        <property type="gene ID" value="HMPREF0994_03600"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100170_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN39509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="197" mass="22149" checksum="D275D053ADB162F7" modified="2011-09-21" version="1">MAPKQKITREQLLEVAFDITRKEGFSAVTARSVAKAAGCSIQPVFSQFDTMEALRTATFDYACEHFMNEIMEKKDRPDFIACTSRWVLNLARKEPNLFHLLYLSDSFQGDNLWNVMMGYESNSKMAAVFRESYGLEEEECKDIFLRGYLLLHGIATMIATNHMNFTDDEAAEMVKRTVEDMVAGAGRRAAAASGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCT9</accession>
    <name>F7KCT9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253569.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03668"/>
    <dbReference type="EnsemblBacteria" id="EGN39040">
        <property type="protein sequence ID" value="EGN39040"/>
        <property type="gene ID" value="HMPREF0994_03668"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4002"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_8_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="438" mass="49241" checksum="EC8CFB548D52FBFF" modified="2011-09-21" version="1">MQYNIMDYGALPDGKTNNQKQIQAAIEDCAKTGGRVLVPAGNFLSGTIQLKSNVELYLEKGSVLTASNSPEDIIDFSEDRDAMDGIENGCFLYACHARNITIAGEGTIDGQGRKVYLDDNADEGFHECPLAVAGFRARTTYLEDVDGLQVRGITFYDACFWTLHMAGCQNVIVDGIRIFNNDRGPNNDGIDPDGCRNVIIRNCIIESGDDSIVLKATRPVWEKYGNCENIVITNCILHSRDSALKIGTETWGDIRNVIFGDCVVRDCSRAVGIWVRDGGTIEDIQIHHITGNTKRYADGVNRTFAPRWWGKGEPIFLSAGYRKGEKKYPGKIRRITFDHIRLYSESALFLAGEEDSVIEDIRITDSRITWKKQSVHNPGVFDEQPSDRDVYEHRIPWLYTRYVEGLTVEGIYEIDPSLEGYVDREEILEESSRISIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD25</accession>
    <name>F7KD25_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253655.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03754"/>
    <dbReference type="EnsemblBacteria" id="EGN38819">
        <property type="protein sequence ID" value="EGN38819"/>
        <property type="gene ID" value="HMPREF0994_03754"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="326"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN38819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="599" mass="68087" checksum="B9CDECFC8A2285ED" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDK6</accession>
    <name>F7KDK6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253852.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03951"/>
    <dbReference type="EnsemblBacteria" id="EGN38716">
        <property type="protein sequence ID" value="EGN38716"/>
        <property type="gene ID" value="HMPREF0994_03951"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4302"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_14_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="489" mass="55764" checksum="7328F197CF615CCD" modified="2011-09-21" version="1">MRVIMFDIDTLRADHMGCYGYGRDTTPVMDSVAQQGVCFDRYYCPNAPCLPSRASLISGQYGIHNGIVGHGGTAADMRLQGASRSFTDDMSENGLFMQFRRAGFHTVSFSSFAERHSAWWFNAGFNECFNVGNRGGESAEMVTPHVLDWLERNGEGDNWMLHVHYWDPHTPYRTPADYESRFQDTPLPDDWITEDIFKEHLLHIGPHGANEINMWNDDTFKQWPKHPGRLETKEAAKHLIDLYDDGVRYTDDNIGMILDYLKEKGLYDEDLAIIITADHGEDLGEFGVYGEHGMADEPVCRIPMIIKWPGVEGGRHVNGFHDNVDLLPTVQELLGTERFGSYHYDGVSYAGTLLEGTDCSRPYEILTQCAHVCQRSARFDHYVYIRTVHGGYHLLPDEMLFDLEADPHEQHNLAQERPDLCAKGAKLILDWNDAMMKTSAYDADPMWTVMREGGPEHCRGHLQAYMERLKGTPREYGIELLTEKYKGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE06</accession>
    <name>F7KE06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN37121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253986.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04085"/>
    <dbReference type="EnsemblBacteria" id="EGN37121">
        <property type="protein sequence ID" value="EGN37121"/>
        <property type="gene ID" value="HMPREF0994_04085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4458"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN37121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="236" mass="25974" checksum="93CC9575BE04F899" modified="2011-09-21" version="1">MSMLTVENLNVYYGMIHALKGLSFHVEEGEIVALIGANGAGKTTTLQTISGILQAKSGSVNFQGKEITSVPGNQIVKLGMSHVPEGRRMFSNLTVYENLMMGAYTRKDKKQIAETLEKVYERFPRLQERTRQLAGTLSGGEQQMLAMGRALMAQPRIILMDEPSMGLSPLFVNEIFNIITEVNKQGVTILLVEQNAKKALSIANRAYVLETGRIVNEGDAHALLDDESIKKAYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEH8</accession>
    <name>F7KEH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04263"/>
    <dbReference type="EnsemblBacteria" id="EGN36543">
        <property type="protein sequence ID" value="EGN36543"/>
        <property type="gene ID" value="HMPREF0994_04263"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4657"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363699" evidence="2">
        <location>
            <begin position="28"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="476" mass="52219" checksum="472813A6A0D23413" modified="2011-09-21" version="1">MFMKKKLAVLLTVTLLAACAAGCGSTAEEKKETNTTAAQESVSEASTDEGDKTKAAESDVELTFSAWAGATEKAVLEEALAGFTDATGIKVKGIFIPDDYETKISTMIASGTAPDVGYLVAPTAHDWYADGQIMDLTPLMEEDSSFKKEDLLDAAYSYYDDEAIDALLLSLQTYAVFYNKDLFEKAGVPEPSADKVWTWDEFVETAKKLTFDSNGNSALDADFDAGNIQQYGVYINPKGPTIVEPLLVRNTSVGYTDKDGTEYGLKNPEAVDFLQKLADLINVEHASPSTTTAQGLPSADLSLQTGKYAMVVDSQYMLSNFAKLESLNLGLAPLPSNGNNTILTSSGCKVIFSQTKYPEEAWELMKWLSDPAESLELYSSGLWMPIKSDWYTDESKVEQWAGEGKSHPSGYKEVFLNPVWENSELSSEHRMKHYNQINDIVFPALDKVWTGEQTVQDALDKVMPEVDKIFDGVFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KER7</accession>
    <name>F7KER7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antibiotic transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254247.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04346"/>
    <dbReference type="EnsemblBacteria" id="EGN35656">
        <property type="protein sequence ID" value="EGN35656"/>
        <property type="gene ID" value="HMPREF0994_04346"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4746"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="34654" checksum="655D096A1C068B6C" modified="2011-09-21" version="1">MKDIVMEAKDLTKKYKEAVVLDHINLQLEKGKIYGFIGRNGAGKTTFLRLITGLAFPTCGTLALWGKSGTQELQTQRKRIGCMIETPALFPSLSAHQNMEVQRLQRGIPDKTIIDKCLHMVHLEDTGKKAVRNFSLGMRQRLGIAAALLNMPEFLILDEPINGLDPAGIAEIRNLLKHLNQEYGMTILISSHILEELSHTASQFILIEKGKIIEELSDSELNERCRQHIAIKSADPQNTLLILEDKLQTDNLQLMPDGTIRLYDHLENMEQVARILLESHILVTELHLSGDTLEDYFLRRVGGYSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEX8</accession>
    <name>F7KEX8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254315.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04414"/>
    <dbReference type="EnsemblBacteria" id="EGN35724">
        <property type="protein sequence ID" value="EGN35724"/>
        <property type="gene ID" value="HMPREF0994_04414"/>
    </dbReference>
    <dbReference type="GeneID" id="29726777"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388204_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="605"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="711" mass="82986" checksum="F4FEB77B17B2E90E" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF29</accession>
    <name>F7KF29_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254372.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04471"/>
    <dbReference type="EnsemblBacteria" id="EGN35781">
        <property type="protein sequence ID" value="EGN35781"/>
        <property type="gene ID" value="HMPREF0994_04471"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4882"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="8">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="6">
        <location>
            <begin position="180"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="7">
        <location>
            <begin position="291"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN35781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="603" mass="70201" checksum="5FA8AA503CA27BBA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF31</accession>
    <name>F7KF31_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04473"/>
    <dbReference type="EnsemblBacteria" id="EGN35783">
        <property type="protein sequence ID" value="EGN35783"/>
        <property type="gene ID" value="HMPREF0994_04473"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4885"/>
    <dbReference type="eggNOG" id="COG4189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902760_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="340" mass="37613" checksum="F9D96FC31D42344D" modified="2011-09-21" version="1">MKTNKKRISLDLNNLEQTALVGKALSSEVRLEILKLLIEKSANISEIAAAFGLPQSSAALHVKVLEEAGMISVSEKPGVRGAQKVCGITFEDIYLNAFQHKMDHSDSKEFRQIMPIGNYFDFEVSGNCGIISEKGYLGVEDSPSSFYCHNRNEAQLLWFHTGFVEYRFPTYLLKNCRLKEVSFSFEVCSEAPGYQNDWPSDITVWINGREIATILSPGDFGGRRGRLNPEWWGDTMTQYGIYKTIRINPLGCFEDDIKCSDLTLSALCLNEGSYISFRLGVKPDAVHAGGMNLFGEKFGDYAQALVMKVKAANGDSQKKEPDDLQPDGAPGSSSAGQSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFS8</accession>
    <name>F7KFS8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34633.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360146.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04707"/>
    <dbReference type="EnsemblBacteria" id="EGN34633">
        <property type="protein sequence ID" value="EGN34633"/>
        <property type="gene ID" value="HMPREF0994_04707"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="6">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN34633.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="26945" checksum="F6305213559F0636" modified="2013-09-18" version="2">MIKVLIAEDMPALLKKYQRLLEKDSELEVVAAVQNGYEAVMKTVLCQPDVILMDIEMETRTAGLDAASQILSQYPEVKIIILTSYEDDENVFQAFKLGVSDYVLKNSKQEELIACVKDAYAGRSPIRPVIAEKIRREFQRVKQSEDSFLYNLMLVTQLTQTEIDILDLLRQGYERSEICSMRCVEMTTLKRHIHNILKKFDLDSMAEVVKLVNDLKIYDYLHNVKNMDLKDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG43</accession>
    <name>F7KG43_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254723.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN34449">
        <property type="protein sequence ID" value="EGN34449"/>
        <property type="gene ID" value="HMPREF0994_04822"/>
    </dbReference>
    <dbReference type="GeneID" id="29727720"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5263"/>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_298407_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1007" mass="117226" checksum="F48866A912314A8D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG68</accession>
    <name>F7KG68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254752.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04851"/>
    <dbReference type="EnsemblBacteria" id="EGN34478">
        <property type="protein sequence ID" value="EGN34478"/>
        <property type="gene ID" value="HMPREF0994_04851"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5295"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="287" mass="32585" checksum="4CDDFE4B635110FC" modified="2011-09-21" version="1">MVSALQITDLTKEYPGFKLDHVSFTLPQGTIMGLIGENGAGKSTTINAILDLIKRDEGSVTFWGEELSKNPRQLKENIGVVFDGINFYETLTPVKVGKISAAAYRQWNPVVYKDYLDKFQLPSNQEIKTFSKGMKMKLCIANALSHDSKLLILDEATSGLDPVMRDDILDIFLDYIQDENHSILMSSHITTDLEKIADYVTFIHEGKIVFSKTKDELIYNYGILRCSKDDFDRIDPGDILAYRKEDYQWNVLVADRDKAMARYRNVIVDHPTIDDILLLYVKGEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH86</accession>
    <name>F7KH86_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05225"/>
    <dbReference type="EnsemblBacteria" id="EGN33258">
        <property type="protein sequence ID" value="EGN33258"/>
        <property type="gene ID" value="HMPREF0994_05225"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3169376_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="47" mass="5704" checksum="B85D51E03AC32F54" modified="2011-09-21" version="1">MTLQILFPDFNYLFGIEHFFFITLCNSNKFLFKNIYTTAIDKMKNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHF4</accession>
    <name>F7KHF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255126.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05283"/>
    <dbReference type="EnsemblBacteria" id="EGN33018">
        <property type="protein sequence ID" value="EGN33018"/>
        <property type="gene ID" value="HMPREF0994_05283"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5768"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN33018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="234" mass="25992" checksum="35E194AC33ED0FF7" modified="2011-09-21" version="1">MSALVEVKDMCKVYNPGENEVRALDHVNVSINENEFVAIIGHSGSGKSTLMNMLGCLDVPTSGTYLLHDQDVSRMSDDDLSDIRNREIGFIFQGFNLIPNLTALENVELPLIYRGISKKERLELSQDALRKVGLEKRMNHKPSEMSGGQQQRVAIARAIAQAPPVILADEPTGNLDSGSTKEIMGILKSLHQEGRTVIIITHDNDIAAQAERVIRIKDGYIEADYNQDTENYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHK2</accession>
    <name>F7KHK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255174.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05331"/>
    <dbReference type="EnsemblBacteria" id="EGN32772">
        <property type="protein sequence ID" value="EGN32772"/>
        <property type="gene ID" value="HMPREF0994_05331"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5822"/>
    <dbReference type="eggNOG" id="COG5523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045673_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010380">
        <property type="entry name" value="DUF975"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40076">
        <property type="entry name" value="PTHR40076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06161">
        <property type="entry name" value="DUF975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="244" mass="27327" checksum="41037E78C6C1BEBE" modified="2011-09-21" version="1">MDRHASSAELKAKAKGQMLGKYGTLVPAFLVVEAIMVTINFLATFSLDTRAMTGLTIQFVIECLLQLLAGIFIAGQTYMYLNVSCGGNIKISDVFYGFTNHPDKAILIQLLQLLLCLVFFIPLFICLGVFAFTDSSLSVMLLLISITFCIGLVGSTIISLQYSQSYFVMLDFPDFTAVQCLRYSREIMKGNKARRFYLGVSFIPLYLLGLLTCCIGLLFVTPYANTTFSNFYLELMSYRNRHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHN6</accession>
    <name>F7KHN6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255208.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05365"/>
    <dbReference type="EnsemblBacteria" id="EGN32806">
        <property type="protein sequence ID" value="EGN32806"/>
        <property type="gene ID" value="HMPREF0994_05365"/>
    </dbReference>
    <dbReference type="GeneID" id="29727597"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363779" description="SBP_bac_5 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="110"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="545" mass="58919" checksum="D73FD02D4B9FF0C3" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHS5</accession>
    <name>F7KHS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxy-3-oxopropionate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05414"/>
    <dbReference type="EnsemblBacteria" id="EGN32855">
        <property type="protein sequence ID" value="EGN32855"/>
        <property type="gene ID" value="HMPREF0994_05414"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5917"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006398">
        <property type="entry name" value="Tartro_sem_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01505">
        <property type="entry name" value="tartro_sem_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="4">
        <location>
            <begin position="164"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="294" mass="31081" checksum="6A300B7CE23C1690" modified="2011-09-21" version="1">MKIGFVGLGIMGKPMAKNLLKAGYELNICDINEDAVADVAAAGGVPYKTAKETAACSDAILTMLPNSPQVKTVIEGKDGILEGMKQGTVIVDMSSIDPTVSIELEKEVAEAGGELIDAPVSGGEPKAVDGTLSFMCGGKPEVFDRVKPILEKMGASIVLVGPIGSGNMTKLANQIIVGVNIAALSEALVLAAKSGVNPENVYQAIRGGLAGSTVMDAKAPMMLDRNFDPGFRIELHIKDLTNAENASRAVGMELPMTEQVLAMMKKLQEEGMGKCDHSALLRYYEEKENIEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIC3</accession>
    <name>F7KIC3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05602"/>
    <dbReference type="EnsemblBacteria" id="EGN32313">
        <property type="protein sequence ID" value="EGN32313"/>
        <property type="gene ID" value="HMPREF0994_05602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3502" evidence="1">
        <location>
            <begin position="363"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="498" mass="57795" checksum="88B4A769AB1253CE" modified="2011-09-21" version="1">MEEMTLHICLFGTRPEGFDDVVAEAEERLRDTLNVTFNFEFISPVEYKSTLQMQLMAGRKVALAYDAPWMTNNELVSNGMYYDLQEYFNNDKYPGLKKAFPEEVIEANRINGHLYWIPIMGVEKDMVMLYIREDLRERCGVGPVSDMASLERFLDAVREKYPDMIPMDLGRKGFYEFFNDESVERNRAGIFEPFGTGNMELYWEAAISKDGKTCLGATTYGDEDAAFAEYPEGYQYNYYMERFEKFTEWNKFLVENSITVATPGGYDSQDTFINGDTAVCIGTLSRGSIERELQENYPEGKVAFLPLYAEQREMKEKAVYTNRIANNFVGIPITASEEQKERTVLFLDWLFADRENYELFRYGIEGRDYEITGEGSYTVRSAANRYTFPYYELVWNVGYELSNSDTPEILLAYQKYMEKDSTYVDSPLAGFVYNSSDVRTELAAVNEEYRKIWFQLFHGTYSDVEQALKGYHARAEEAGLEIIRRDLVKQIQTFLDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIL1</accession>
    <name>F7KIL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32179.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360180.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05690"/>
    <dbReference type="EnsemblBacteria" id="EGN32179">
        <property type="protein sequence ID" value="EGN32179"/>
        <property type="gene ID" value="HMPREF0994_05690"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32179.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="33109" checksum="A29455ABA09334F3" modified="2013-09-18" version="2">MKKIKKGRAVFSVVNYMFLSLLALLCILPLLTILAMSFSSATAVAAGKVTLWPVEFTTMAYQYVIEKKEFWTSLLKSVERVLIGVPLSMILTILIAYPLSKEKEQLRARGVYVWLFFFTMLFSGGLIPGYLLITNLHLMDTIWALILPTILSVYNIVLMINFFRGIPKELEEAAIIDGASHFTTCFRVYVPCAKPSIATLTLFSFITQWNSYFDGLIFSNFPSSYPLASYLYTVVVKRDLSLLSIDEIKLLSVVDDRTIRCAQIFISLIPIMLIYPFAQKYFVKGMTVGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIS6</accession>
    <name>F7KIS6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05707"/>
    <dbReference type="EnsemblBacteria" id="EGN32196">
        <property type="protein sequence ID" value="EGN32196"/>
        <property type="gene ID" value="HMPREF0994_05707"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6238"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="74"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="34367" checksum="7DFEBE561A859BB8" modified="2011-09-21" version="1">MEDLERKGFRSEAVRKEILRLKKKRKRRRIRIMLILGIIVVLCSAVILKSDFIDNKQIELTYYQLSSDQINSPLRLVIMADLHSGTFGEKNERLKKQLQELKPDLILMAGDMINETDTDVSGIVDLCGYLVKIAPVYYILGNHEGNLMYTGKKVPLDKYLYEAGVHFMYTNYETITVNGNVLKIGAMAANAETYNEEDAQFEAEFEEGKEFKILMAHYPDLFTDRLQSVKVDLGVAGHYHGGLIRIPGIGGLFHWDTGFFPAYAGGLYPWGEGNLIVTRGLGNHGLIPRINNKPELVVVDISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIX2</accession>
    <name>F7KIX2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NitT/TauT family transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255577.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05801"/>
    <dbReference type="EnsemblBacteria" id="EGN31877">
        <property type="protein sequence ID" value="EGN31877"/>
        <property type="gene ID" value="HMPREF0994_05801"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6343"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061540_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363813" evidence="1">
        <location>
            <begin position="28"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="339" mass="37412" checksum="96C7FA1400426961" modified="2011-09-21" version="1">MKKRILAFTLVLAMTLFCFAGCGKKQEAVKDTPDKTMTDVTLNEVAHSIFYAPMYVAIEEGYFAEEGINLTLVTGFGADKTMTAVLTNEADIGFMGSEASIYTYLGGTEDYVVNFAQLTQRAGNFLVAREPIDNFSWDMLKNCTVLGGRAGGMPEMVFEYILRKNGIDPMADLDIDQSIDFGSTAAAFSGGQGDFTVEFEPHATALEQKGDGYVVASLGEDSGYVPYTAFSAKKSYIEAHPDVVQAFTNALQKGMDYVQSHTPEEIADVIQPQFEETDKETITTIVTRYYDQTSWKDNLIFEEDAFTLLQNILEESGELSQRVPYADLVNTEYAQNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ98</accession>
    <name>F7KJ98_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN31565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255713.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05937"/>
    <dbReference type="EnsemblBacteria" id="EGN31565">
        <property type="protein sequence ID" value="EGN31565"/>
        <property type="gene ID" value="HMPREF0994_05937"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010985_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="249" mass="28360" checksum="50B445A6CDA254F0" modified="2011-09-21" version="1">MFDLSRVGKQIKKYRINADMTQMELAERMGVSFQAVSSWERSETMPDISRLVELGEIFQVSVDEILDHQEKTSTVKRLINPQDEEISIKELEELEGIIKPSDISKYKLKIGSMEEIEYIITFVGRDMATELVKSNKDLINSIYDMNAIAPFISRELMDNIVCENLSKIKDIQELLNIVAFTCRETADKAALQFEKADLTMEQIVSLAPFISRETVDKMVLSSGLHAECLQDIFPLLPFISNDIIKDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJF1</accession>
    <name>F7KJF1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05980"/>
    <dbReference type="EnsemblBacteria" id="EGN31334">
        <property type="protein sequence ID" value="EGN31334"/>
        <property type="gene ID" value="HMPREF0994_05980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6546"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_0_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="250" mass="29295" checksum="C940615FB4650967" modified="2011-09-21" version="1">MQIKINEAAKLTGVTVRTLHYYDQIGLLRPETVTDTGYRLYGEKDLERLSQILFFRELDFTLAQIKDMLDSPSFDRKEALRAQHELLTKKKERLERLIDLTKRRMEGNAEMSFREFNKEEIERCKEKYAQEAEERWGGTQAYKESKKRTDSYGSAEWEELTQKGNSIMQAFADCRGLSPESEEVQELAARWQAYISSSYYDCTDEILEGLGLMYTSDERFRQNIDRFGEGTAELMSQGIACYVRNKRDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJL1</accession>
    <name>F7KJL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NitT/TauT family transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255821.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06045"/>
    <dbReference type="EnsemblBacteria" id="EGN31399">
        <property type="protein sequence ID" value="EGN31399"/>
        <property type="gene ID" value="HMPREF0994_06045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6617"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_4_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="54"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN31399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="28439" checksum="E23734A5A4AF1C53" modified="2011-09-21" version="1">MRRQKAQNRIRPWAVALWLVVWELASLYIGQEILLVSPVSVLRRLCDLALRPDFWSSIAFSFFRIIGGFLLAAFFGTLLAGLAGAFSFLRDLLAPAMAAVKAVPVASFIILILIWVPSRNLSIVISFLMVLPVIYTNVLNGIRSTDPKLLEMARVFRIPLFRRIRYIYLSQLLPFLRTGFSLSLGLCWKAGVAAEVIGIPKGSIGEKLYEAKVYLETPDLFSWTLVIVFISVIFEKIFLRLIDEGVGMIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK15</accession>
    <name>F7KK15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YabP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255981.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06205"/>
    <dbReference type="EnsemblBacteria" id="EGN30698">
        <property type="protein sequence ID" value="EGN30698"/>
        <property type="gene ID" value="HMPREF0994_06205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6795"/>
    <dbReference type="eggNOG" id="ENOG5032YWW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168343_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012504">
        <property type="entry name" value="Spore_YabP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038705">
        <property type="entry name" value="YabP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011576">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02892">
        <property type="entry name" value="spore_yabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN30698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="96" mass="10711" checksum="8796EB5103C22523" modified="2011-09-21" version="1">MEDLNTTRDRRHKVVLTDRGICNISGVCDVLSFDVAEVLLETEQGMLMIKGNDLHVSRLMLDKGEVDVDGKIDSLTYSENTGYGGKGESLFTRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKA5</accession>
    <name>F7KKA5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06284"/>
    <dbReference type="EnsemblBacteria" id="EGN30203">
        <property type="protein sequence ID" value="EGN30203"/>
        <property type="gene ID" value="HMPREF0994_06284"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6888"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="288" mass="32186" checksum="2BA80566A33954F9" modified="2011-09-21" version="1">MELKGIVPALVTPFDRDGNVNYEELKKLVRLLLEEGADGFYVTGSTGECFLLTDEERIRITSVVAETVEGKVPVIAHVGKIGAKQAAYLARESQKAGASAVSSVPPFYYDFKFEEIVRYYAAISDSVDVPVVVYNFPQYSGVTINASNLAQIMEHCRVGGLKYTDSNLYELERIRTSYPELKIMFGQDEAFLYSLPVGVDGAIGSTYNFMLKKYKRILNAYREGKMQEAEAIQHEACRIIDRLLCVRDITAVKYLLGRKGISCGNCRLPFSPITEQEKKLLDDIGDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKF8</accession>
    <name>F7KKF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,3-beta-galactosyl-N-acetylhexosamine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256099.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06337"/>
    <dbReference type="EnsemblBacteria" id="EGN47945">
        <property type="protein sequence ID" value="EGN47945"/>
        <property type="gene ID" value="HMPREF0994_06337"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6940"/>
    <dbReference type="eggNOG" id="COG5426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022367_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035080">
        <property type="entry name" value="Lact_bio_phlase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012711">
        <property type="entry name" value="Lacto-N-biose_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035356">
        <property type="entry name" value="LBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035363">
        <property type="entry name" value="LBP_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09508">
        <property type="entry name" value="Lact_bio_phlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17386">
        <property type="entry name" value="LBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17385">
        <property type="entry name" value="LBP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02336">
        <property type="entry name" value="TIGR02336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lact_bio_phlase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_M" evidence="2">
        <location>
            <begin position="449"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_C" evidence="3">
        <location>
            <begin position="670"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN47945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="723" mass="82262" checksum="78AA87D2B67EB9D7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKM1</accession>
    <name>F7KKM1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06400"/>
    <dbReference type="EnsemblBacteria" id="EGN48008">
        <property type="protein sequence ID" value="EGN48008"/>
        <property type="gene ID" value="HMPREF0994_06400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7006"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044042_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="55583" checksum="9666EEF0D7E1A569" modified="2011-09-21" version="1">MFDAIKLFYSCVGVIFVIYLLGYSTFLILSVLYGSLELYREKKKKKYHNEISHDYYVPVTIVVPAYNEEITVVDTVKSLLMMDYKLYEIVVVDDGSKDNTTQALLDAFPLRKVNRPINQQIPSKKVVDVYETVIDGVEVTLVRKENGGKADALNVGINAARYPYFICMDADSVLQRDSLKEIVKPVLQDDTIVAVGGLVRISNCAVLKQGELVDYHMPWNPIVGMQILEYDRSFMASRVFMDRFNGNLIISGAFGLFRKDMVSAVKGYDTSTMGEDMELVVKLHSFCRINKIPYSIRYVPDAICWSQCPSSIRDLQKQRRRWYLGLFQCLKKHRRMFLAPEYGVVGYVSYLYYLIYELLSPFIELFGLLTIILAYAVNLINVPFMLLFFLIYALYGAILTITAFFARIYTQNIRLSVLDVLKSIYLCLAESVFFRFIQAFTRMTAFIGYRKKKNVWGQIQRQKIQLNQSSEQNVEKKIEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKP1</accession>
    <name>F7KKP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256182.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06420"/>
    <dbReference type="EnsemblBacteria" id="EGN48028">
        <property type="protein sequence ID" value="EGN48028"/>
        <property type="gene ID" value="HMPREF0994_06420"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033KMA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="75" mass="8962" checksum="1BC409F5E4C28563" modified="2011-09-21" version="1">MLELIRKIVFQVTGKNDINYDTDFVQDLRLNSYEIMNIVSAFEEYFDTTIPNRDVWQLHQVKDVISYMEEKGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKW4</accession>
    <name>F7KKW4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256255.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06493"/>
    <dbReference type="EnsemblBacteria" id="EGN47504">
        <property type="protein sequence ID" value="EGN47504"/>
        <property type="gene ID" value="HMPREF0994_06493"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7109"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN47504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="298" mass="32969" checksum="79F7777EBA0E5E66" modified="2011-09-21" version="1">MKNPGTKTGKKHKFTMGMAVLYFLLTALVFICLYPFLNVLAYSLSGYNAVLSGDVTFYPIEFTLDAYKQILGRAQIWIAMRVTIFVTLMGTAIGLVLTIFAAYALSRKNLPGKKLLSGLILFTMYFSGGIIPTFLVVKNLGMYDSLSSLYIPQAINVFNFIVMRTFFRQLPESLEEAAKIDGASDMGVLLKIVLPLSVPIIATIGLFYAVQYWNGYFDALIYIQSPDKFTLQLRLRSLLFADELNNAGGGNVEGIGTQVMTQSLKMACVAVSTIPILLVYPWLQKYFVKGVMLGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL50</accession>
    <name>F7KL50_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256345.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06583"/>
    <dbReference type="EnsemblBacteria" id="EGN47302">
        <property type="protein sequence ID" value="EGN47302"/>
        <property type="gene ID" value="HMPREF0994_06583"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7207"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="372"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN47302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="590" mass="68216" checksum="6CB4CE9A9EF3A5EA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLG7</accession>
    <name>F7KLG7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256455.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06702"/>
    <dbReference type="EnsemblBacteria" id="EGN46626">
        <property type="protein sequence ID" value="EGN46626"/>
        <property type="gene ID" value="HMPREF0994_06702"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7331"/>
    <dbReference type="eggNOG" id="ENOG50303GB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106157_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16011">
        <property type="entry name" value="CBM9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN46626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="206" mass="24080" checksum="F6FA10254FD76483" modified="2011-09-21" version="1">MEYQVKIIDSPENADKGTLFTIDNYMWTCLTKPKVYGTMTYLKEKGFYVEMTCEEKNPKKEYHNYMDPVCKDSAMEIFLVFPQKGEPLTNDCMYTNFEINANAALYAAYGKGRKNRSSMPRQYLKTCSCRTTIHQDRWTLSLLIPEPFLKKECGLPQLDETTEFYCNFYKISESPEIEHYAAYHPINNPTPNFHLPIHFAKARITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLI5</accession>
    <name>F7KLI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256476.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06723"/>
    <dbReference type="EnsemblBacteria" id="EGN46647">
        <property type="protein sequence ID" value="EGN46647"/>
        <property type="gene ID" value="HMPREF0994_06723"/>
    </dbReference>
    <dbReference type="GeneID" id="29725537"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7352"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028395_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363876" evidence="2">
        <location>
            <begin position="36"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="575" mass="62295" checksum="022DE333BE10815D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLR3</accession>
    <name>F7KLR3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256545.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06792"/>
    <dbReference type="EnsemblBacteria" id="EGN46384">
        <property type="protein sequence ID" value="EGN46384"/>
        <property type="gene ID" value="HMPREF0994_06792"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2000935_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN46384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="13832" checksum="6A51C8743ACB0C5D" modified="2011-09-21" version="1">MLFAAVDPNKKDLKQLVKFLKSSYPGCKIVMFCNPLAAAGYVRSHPVDVLFTEIAMTGMSGFRLKEITEKCNPGALTVFISATAAYAMDALNCRVFDYMVKPVTPEKTRNALKETKFQPFIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRR2</accession>
    <name>S2KRR2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_07189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360115.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07189"/>
    <dbReference type="EnsemblBacteria" id="EPC05134">
        <property type="protein sequence ID" value="EPC05134"/>
        <property type="gene ID" value="HMPREF0994_07189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010964_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="179"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EPC05134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="733" mass="81484" checksum="713565065472403C" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRY1</accession>
    <name>S2KRY1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360038.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07141"/>
    <dbReference type="EnsemblBacteria" id="EPC05194">
        <property type="protein sequence ID" value="EPC05194"/>
        <property type="gene ID" value="HMPREF0994_07141"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_15_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="371" mass="42134" checksum="5320D1563CD8F293" modified="2013-09-18" version="1">MKQLPLYEQIYNDIIEGIENGTYKKGDRLPSEKELSEKYCVSRITSKKALELLAEEGRIIRMAGKGSFVSGAELTEEVQAAEEAERNPNRLIGVIMDGFGPSFGCRLLGSLEMECKNQGFSMVLRCSYGNIEEETRAIDELLQIGVEGIIIMCVHDENYNSKVLQLVVERFPIVTIDRQLKGIPLSFVGTNNEEAARELANYLLNEGYKKICFAMPASRETSTIVERQNGLTMAFREHGMIADESLWITDLKATLPSSRSEENLERDMRRITKFMESHREVEAFFAVEYSIARIIYRCLYHMNLHKKCPVVCFDSSDNIIQESMFTHVRQDEDTIGHTSVRLLADALNGIKEPKTVLVPYQIIEATENGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVP5</accession>
    <name>S2KVP5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_07286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EPC05065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360278.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07286"/>
    <dbReference type="EnsemblBacteria" id="EPC05065">
        <property type="protein sequence ID" value="EPC05065"/>
        <property type="gene ID" value="HMPREF0994_07286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EPC05065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="446" mass="49879" checksum="803D0C3EF1AC537E" modified="2013-09-18" version="1">MEERKVIRELLDSKQYTRLRQMLSELNDADIAALLEEMEEQDMLKVFRILPKDLAADVFSYMDVDNQQFIITSLSDRDAANIVDNLMADDAADLMEEMPANVVKKILANASPETRRDINHLLRYPEDSAGSIMTVEYVDLKENLTVDEAIARIRKIGVDSETINICYVLDSRRKLVGTVALRYLLLSQPDEVISDIMHENVISISTMMDQEEVARQFQKYDFTAMPVVDNENRLVGIITVDDIVDILQEEATEDIEKMAAIVPSDKPYMKTGVLETWKKRIPWLLLLMVSATFTGRIIASYESALSACMVLSTFIPMLMDTGGNAGSQASVSIIRGISLDEIRFYDLPGVIWKEARVALLCGVTLSAANFVKLMLFDRVAVQVAFVICITLVVTVFVAKIVGCSLPMLAKKIGFDPAVMASPFITTIVDALSLVIYFQIATVLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>S2KW15</accession>
    <name>S2KW15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07142"/>
    <dbReference type="EnsemblBacteria" id="EPC05195">
        <property type="protein sequence ID" value="EPC05195"/>
        <property type="gene ID" value="HMPREF0994_07142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="34397" checksum="8E696AA0E665414E" modified="2013-09-18" version="1">MKGQELNKTAKNAGHKTKMKLSVGDRIFNLVNAVIMIIICLVIVYPIYYVIIASITDPVIVNSGRPLFYPVKLYLNGYKTTLSYTPLWTAYGNTISYTVVGTLVSLFATIPAGYALSRKDLPGRRGLIFLFTFTMFFSGGIIPLYLTIRNLGIYNSIWAMVLPVAVSAYNLIVCRSFFEAGVPDELLEASKVDGCSDFTFFFKIAIPLSSTIIAVMCLFYATAMWNQFFNALMYLQDDNKMPLQVVLRNLVLMNQANQMGSSGDAMVTKQKLAEQLKYCIVVVSAAPLLVVYPFIQKYFAKGVTIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWF4</accession>
    <name>S2KWF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent RNA helicase DeaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_06978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359744.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06978"/>
    <dbReference type="EnsemblBacteria" id="EPC05310">
        <property type="protein sequence ID" value="EPC05310"/>
        <property type="gene ID" value="HMPREF0994_06978"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="217"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EPC05310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="525" mass="59727" checksum="43BB0DC948E9C140" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAP7</accession>
    <name>S2LAP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359989.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07115"/>
    <dbReference type="EnsemblBacteria" id="EPC05266">
        <property type="protein sequence ID" value="EPC05266"/>
        <property type="gene ID" value="HMPREF0994_07115"/>
    </dbReference>
    <dbReference type="GeneID" id="29726797"/>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008413_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="864" mass="99292" checksum="9A83D000489CA826" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAU6</accession>
    <name>S2LAU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359760.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06989"/>
    <dbReference type="EnsemblBacteria" id="EPC05321">
        <property type="protein sequence ID" value="EPC05321"/>
        <property type="gene ID" value="HMPREF0994_06989"/>
    </dbReference>
    <dbReference type="GeneID" id="29723612"/>
    <dbReference type="eggNOG" id="ENOG503487Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1439398_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="188" mass="21695" checksum="794111F620D059CC" modified="2013-09-18" version="1">MLDPQITLFSLEATSKPTINPRPNVLLLKSCNIYVFSSGRIYSDFEDMTFNELNNNNFGYGSLDIEFAFINNATKKEYPDFYTKCFVIRTNKNEVIKPMKLSNKKNYSKINKNGELVIGIRYYFINETQISAITGSNSILIEGFIALEKPQNVFAVMCQLEKRNSKWKITSAYTYKPKYAKNIKNLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJH4</accession>
    <name>S2LJH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360257.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05123">
        <property type="protein sequence ID" value="EPC05123"/>
        <property type="gene ID" value="HMPREF0994_07272"/>
    </dbReference>
    <dbReference type="GeneID" id="29728109"/>
    <dbReference type="HOGENOM" id="CLU_1592465_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="167" mass="19053" checksum="22E11D35760B7BD3" modified="2013-09-18" version="1">MINSLGGLGSCNPFKTVFSNNLKNEKSLFGQVLDSVTFVNDSGQEERYGINAEQKQYLKEKYGSLELKIGDKKTLAFMNDLKKMGVITDEEAKCGEYMPVWVASKENTVTSWFNSPNPDDMDIRSSFHIYAILQRGEANKYPELSDFFMKQSSVYEKLDNVMDYIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2C8</accession>
    <name>F7K2C8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249956.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00007"/>
    <dbReference type="EnsemblBacteria" id="EGN48240">
        <property type="protein sequence ID" value="EGN48240"/>
        <property type="gene ID" value="HMPREF0994_00007"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.9"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051810_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN48240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="112" mass="12490" checksum="6CDD3DA4D913E8BE" modified="2011-09-21" version="1">MEVEFMTADTALPPCMPLPRAMLRLPISSTAKVMYARMLDIVFLSGIEDANGILFIHFPIVELAAALARSTMTVKRSLNELEDAGLILRVRQGFGEPNKIYVLIPKKEDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2P4</accession>
    <name>F7K2P4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">HMPREF0994_00123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250072.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00123"/>
    <dbReference type="EnsemblBacteria" id="EGN42740">
        <property type="protein sequence ID" value="EGN42740"/>
        <property type="gene ID" value="HMPREF0994_00123"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.130"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN42740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="95" mass="10353" checksum="0EDD06ED8CE9A1FC" modified="2011-09-21" version="1">MKLVPLGDRIVLKQLEAEETTKSGIVLPGQNKEKPQQAEVIAVGPGGMVDGKEIKMEVKAGDKVIYSKYAGTEVKLDDDQEFIIVKQSDILAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3C0</accession>
    <name>F7K3C0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_00353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250302.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00353"/>
    <dbReference type="EnsemblBacteria" id="EGN33494">
        <property type="protein sequence ID" value="EGN33494"/>
        <property type="gene ID" value="HMPREF0994_00353"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.382"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="256"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="469" mass="53293" checksum="842C44B966E55132" modified="2011-09-21" version="1">MKFSLKLLLCTMIVMALAFGFSGFYFVNYVFETSLDREIKQALDESSILRFAFETAALNVPAKYDVLQDHTVEQIASNLETGGHDTSRMLRVSDEHKNVLYISSGFDAEGGILEQTDENTRTYRVIRREDRYYIQTGMTVNALDRILYLETMKDVSEVFRERALGFSVYRRVTIIMLILGTVIMHLIASFLSKPIRLLTKATKRMSAGDYSYRARQVSNDELGQLTMDFNLMANVLEDNISKLEEEIQAREDFVAAFAHELKTPLTAIIGYADMLRSRKLDEEKSFMSANYIYTEGKRLEAMSLRLLEIIVTKREKIDFQKVSAEMLFTYLENMFVTNRDMEFHFSYEPGMVWAEANLIKSVLVNLLDNACKASEPGSPIEVTGARLENGYRFSVKDQGVGIPKEEQKNIIKAFYMVDKSRSRSKNGAGLGLALCTQILLLHGSRLEIDSTPGKGSCISFVLPDRGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3T1</accession>
    <name>F7K3T1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250459.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00510"/>
    <dbReference type="EnsemblBacteria" id="EGN45514">
        <property type="protein sequence ID" value="EGN45514"/>
        <property type="gene ID" value="HMPREF0994_00510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.559"/>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985909_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="139"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN45514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="286" mass="32794" checksum="C3FE0E220D9806E1" modified="2011-09-21" version="1">MANRNIENITAVIDYVEDHLTEKLDLDRIAEAVHYSKYHLHRMFADTVGLTVHDYIQRRRLTEAAKLLVFSDKPILEIALTAGFESQQAFTACFTSMYKTAPGRYRETERFYPLQLRFHLEGSYAMLEQKQRRQWDIAFAVQEDIPCWMELVRLVVDGFPCLDEAEYIRVLKEKIRTGQALILKDGAMAVGILLFTGETGSIDFMGCHPLYRKMGIPKAFLDKVMGELLKGRELSITTFREGDRADTGHRSEIKGLGFAEAELLVEFGYPTQRFVLHRKEGEDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3U2</accession>
    <name>F7K3U2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar biosynthetic protein FliR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250470.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00521"/>
    <dbReference type="EnsemblBacteria" id="EGN45525">
        <property type="protein sequence ID" value="EGN45525"/>
        <property type="gene ID" value="HMPREF0994_00521"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.570"/>
    <dbReference type="eggNOG" id="COG1684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063626_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN45525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="256" mass="28032" checksum="93B8F146D8127E34" modified="2011-09-21" version="1">MLTEIVVSLNLFLLVFARLGAMIFPSPVFGRKNVPMRIRAGLVLALTLLLVPVLNAGAVSALSGFDMVEGLVREILLGLIVGFVFQIFFFMIFVAGDMLDTVFGLAMGKVMDPGGGVQVSVLGQFLNVFFFLYFFATGSHRLMIKLFAYSFELIPAGAAAVSMEKAGPFVLALFHSVFVLAIRLTLPFVAAEFVLEAAMGVLMKLIPQIHIFVINLQVKIIAGILLMMLFAVPMGQFIDRYIGTLFEDVQKLLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3V4</accession>
    <name>F7K3V4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">csrA</name>
        <name evidence="6" type="ORF">HMPREF0994_00533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN45537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250482.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00533"/>
    <dbReference type="EnsemblBacteria" id="EGN45537">
        <property type="protein sequence ID" value="EGN45537"/>
        <property type="gene ID" value="HMPREF0994_00533"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.582"/>
    <dbReference type="eggNOG" id="COG1551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164837_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN45537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="95" mass="10612" checksum="F3BE2A166DAB9548" modified="2011-09-21" version="1">MLILSRKKGESIIIGEDIEIFVADVKGDKVRLGISAPEDMKISRKELYLTVENNKEASDKVDLLKVFQLSRSLYAQQGTDKAKGKDEPDADTDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K480</accession>
    <name>F7K480_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250621.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00672"/>
    <dbReference type="EnsemblBacteria" id="EGN44860">
        <property type="protein sequence ID" value="EGN44860"/>
        <property type="gene ID" value="HMPREF0994_00672"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.728"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="255" mass="28468" checksum="0B57592A81291D76" modified="2011-09-21" version="1">MKDFIRICDVEKYYGTGTNVTKAVDRVSFHVEQGEFLGIMGASGSGKTTLLNILSTIDTVTSGHIFYENDDITLMNEDQLSDFRRDNLGFVFQDFNLLDTLTIRENIVLALSLQGKQGKKSEEKAREVMDILDIAAIQDKFPYQVSGGQKQRCACARALVTGPKLILADEPTGALDSKSSLMLMETFHQLNTTMCSTILMVTHDAFSASWCKRILFLKDGQIFHELVRSGQDRRQFLNEILDVLALTGGELNHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K494</accession>
    <name>F7K494_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar protein FliS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250539.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00590"/>
    <dbReference type="EnsemblBacteria" id="EGN44778">
        <property type="protein sequence ID" value="EGN44778"/>
        <property type="gene ID" value="HMPREF0994_00590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080373_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN44778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="123" mass="14714" checksum="52428D1299F028EA" modified="2011-09-21" version="1">MNKNGYQQYKEQSVNTMTKGEMLLLLYDELLKRLMRAELALGKEDYETFTNSVIRCRDIVCYLRDCLDPQYAISSELRRMYEFFLYEFGRLEAGRNKEIIQEVRPLVTELREAFQEADKIAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4B5</accession>
    <name>F7K4B5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44043.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359865.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00694"/>
    <dbReference type="EnsemblBacteria" id="EGN44043">
        <property type="protein sequence ID" value="EGN44043"/>
        <property type="gene ID" value="HMPREF0994_00694"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026490_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356621" evidence="1">
        <location>
            <begin position="28"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44043.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="421" mass="46301" checksum="3B85CCEDF85D5CAA" modified="2013-09-18" version="2">MKAKNRKVKRMTAIFMAAAMSMTLLAGCGGKTLTEEELSFCQTDVGTLTAPDHVMIVGLGESSHGASEYQQMKAEVFKALVNNNGCRTFVIEGDFGGGLKVDAYIHGGEGTAQEAVAELGFGIYRTKELAELADWMRSYNAEAAEGRDLHFYGMDMQRYDNNKEYLFSVLDEAAPELSEEYKEIFSQLTDDNRYVLDNTALEQAQTDALALLKAMDEKEEEITAVSGKRNFAFARECANSIYESSELCASGTDYNSLRDGHMAEKVEWFVSQGDGSLIFINGHNGHIGKSSVSGYTCLGARLTEAYGDGYFAIGTDAAATRFNSQKDSGGFEVMEVKNKNDLNRQLDKLQGDYYYLDFSEVSGDSGWQEILNSSQKITSLNVGIAGWQKISKMFYTQAVVPSADFDGMIVFREVSPTAIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4H3</accession>
    <name>F7K4H3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250688.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00739"/>
    <dbReference type="EnsemblBacteria" id="EGN44088">
        <property type="protein sequence ID" value="EGN44088"/>
        <property type="gene ID" value="HMPREF0994_00739"/>
    </dbReference>
    <dbReference type="GeneID" id="29724438"/>
    <dbReference type="eggNOG" id="ENOG5032M3V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803415_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN44088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="310" mass="35603" checksum="1E9A8D2E30E120AB" modified="2011-09-21" version="1">MTQSKELQNEKLINDLYEKLHWYTFEASDEQFDAEEVDAIVQLLDVLEPMKEDPRYPSDPAAARERFDRRFGVEEDGAERVIEGVADVEGDESVKISNSMSVAGIGSGKAGIKKVWKRKNVFVRVGVGVAACLVLMLSVNVGSYALKKKSFFEVVYDEIGRTKLTVTGNEETLEDDEVIMEFSTWTEVENYLSMDLLEPEYLPPNYIIKKITLRDCGSRTILLVRYENSLSDNVLQIEVDFYEGDYSERTLVNDANWTLLQDIHDELNSQYFENNKYKSVKVIFTKDKNVYILLCQESVEELKKITESMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4M1</accession>
    <name>F7K4M1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43513.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359876.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00804"/>
    <dbReference type="MEROPS" id="S26.011"/>
    <dbReference type="EnsemblBacteria" id="EGN43513">
        <property type="protein sequence ID" value="EGN43513"/>
        <property type="gene ID" value="HMPREF0994_00804"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43513.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="208" mass="22635" checksum="6270BCD5ED186C74" modified="2013-09-18" version="2">MNRKRKKITLSGIIGGLLCLLFIPVIVINLVLIINSYINPEELPGVLGIKPAIVLSGSMEPAIQTGDLVFIHKTETEKLRVGDVICYLDSGAAVTHRIIAVTDGEDGLPRYITKGDANDAEDHLSVAADQIQGIWKGGRISGLGNALLFMQTTTGMLLFIVLPLLLFFIWDIGIRYHSDKKEAVSRAELEAELSALKAEKENGKTAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Y7</accession>
    <name>F7K4Y7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartokinase</fullName>
            <ecNumber evidence="12">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HMPREF0994_00916</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="12"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250865.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00916"/>
    <dbReference type="EnsemblBacteria" id="EGN43225">
        <property type="protein sequence ID" value="EGN43225"/>
        <property type="gene ID" value="HMPREF0994_00916"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1001"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_2_9"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="376"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="6"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGN43225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="439" mass="48577" checksum="17299D4E505F7A74" modified="2011-09-21" version="1">MKKVVKFGGSSLASAEQFMKVSGIIKADDERRFVIPSAPGKRNKKDTKVTDMLYACYEAVENDKPCQELLKAIEARYEEIIKGLGMALSLKEEFKTIAENFKKKAGKDYAASRGEYLNGIIMAAYLKFTFIDAAEVIFFDENGNFDAAKTDKVMSERLEKEEYAVIPGFYGSQPDGSIRTFSRGGSDITGSIVAKAVHAEVYENWKDVSGVLIADPRIIPNPVVIDTITYKELRELSYMGATVFHEDAIFPVRKEGIPINIRNTDAPEDKGTWIVESTCQKSKFVITGIAGKKGFCSVNIEKDMMNAEIGFGRKVLQAFEDSGISFEHVPSGIDTMTVFVHQDEFMDKEQKVVSAIHRLAHPDTIDIESDLALIAVVGRGMKSTRGTAGRIFSALAHANVNVKMIDQGSSELNIIIGVRNEDFEAAIRAIYNIFVLVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7K504</accession>
    <name>F7K504_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250889.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00940"/>
    <dbReference type="EnsemblBacteria" id="EGN43249">
        <property type="protein sequence ID" value="EGN43249"/>
        <property type="gene ID" value="HMPREF0994_00940"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1027"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="277"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN43249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="496" mass="56012" checksum="8149A0EBFCA805AC" modified="2011-09-21" version="1">MLTRLKELIYKIPVLRSMKVYIFLLMLIMGILPSIFMRIGILQSYEERAVDLRTSDTQTQFKIIANHLLNNNYLQDTSSEAINAELEQMSNLYDGRVIIINSNFRVVKDTYSISEGKTMISEEVILCFKGQSRTKYDKKNGYIEMTIPIEETTSGKNQTGAADAVKKENGSQVQGVMLASVSTDSIAATMELLNRKALIIEIVMIICIFGVAVGFSTILVKPFNRVTQAITEVKDGFTDEPIAVPDYIETEHIIDAFNQLLTQMKVIDDSRQEFVSNVSHELKTPLTSMKVLADSLMQQQDAPVELYQEFMQDIADEIERENKIINDLLSLVKMDKTAAQMNITSVDVNELIESVLKRLRPIARLRDVEVVFESIRPVTAELDEVKITQVFTNLVENAIKYNKEHGWVKVLLDADHQFFTVEISDSGIGIPESDYDHIFERFYRVDKSHSREIGGTGLGLAITRNAVLLHRGSVKVSSLEGQGTCFTVKIPLTYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K522</accession>
    <name>F7K522_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250908.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00959"/>
    <dbReference type="EnsemblBacteria" id="EGN43268">
        <property type="protein sequence ID" value="EGN43268"/>
        <property type="gene ID" value="HMPREF0994_00959"/>
    </dbReference>
    <dbReference type="GeneID" id="29725689"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1047"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084654_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="258" mass="29448" checksum="221990A053B91546" modified="2011-09-21" version="1">MHLAVCDDNIADRKQTERLLGRESDRRSNTTGVLYVDSFGNRNAILSTPMIYDGLFMDMVEDGCNAAEIARELRKAGSRLPIIFCCSKINYREEKDLPDNCYFLDKPIQPDKLTEMVEILLTIKNSQEKKLEFRTDTETFYLKEEDIMYAYPDDRFVRIHLANGENRECVATMLNFCATLGFDIDYSARGTTKLDIGYIRVSESGLLAMIGCSAVINLKYVDKISFFQLSMIDGHKIKISPSSRKALCTMVSEIRTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K580</accession>
    <name>F7K580_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43327.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359893.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN43327">
        <property type="protein sequence ID" value="EGN43327"/>
        <property type="gene ID" value="HMPREF0994_01018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815826_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43327.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="337" mass="39408" checksum="410179E575B09438" modified="2013-09-18" version="2">MEPYYYSQMNKVQQNAYHAMKTGLMSMAPLFMVPKLENRELGDIFFQLRLDCPEIFYASGFHYRFYPEANKVEMIPEYLFEKGKIKEHQKAMESRISKLARPAVNLPEWEKELYIHDFICSSVRYDKLKKAYSHEIIGPLGQGVGVCEGIAKTVKALCDALGIWCMIAISEANPEKKIKYRHAWNIVRIGGKYYHLDATFDNTLGCRDAIRYDYFNLDDARFFRDHEPVIYRAPSCNEGGFSYYITKKLSFTKAEDVEKRAVQAIKKKKILTFHWRGGYLTREKLTELLELLERTGRDKGKYAQVHVNWLQAVLSVRFLDELPEKEVVMEEANEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5E4</accession>
    <name>F7K5E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251022.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01073"/>
    <dbReference type="EnsemblBacteria" id="EGN43046">
        <property type="protein sequence ID" value="EGN43046"/>
        <property type="gene ID" value="HMPREF0994_01073"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1177"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="13"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="561" mass="65355" checksum="1522658E8A308B48" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K680</accession>
    <name>F7K680_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251316.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01367"/>
    <dbReference type="EnsemblBacteria" id="EGN42229">
        <property type="protein sequence ID" value="EGN42229"/>
        <property type="gene ID" value="HMPREF0994_01367"/>
    </dbReference>
    <dbReference type="GeneID" id="29724016"/>
    <dbReference type="eggNOG" id="ENOG50338H7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838999_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="314" mass="36946" checksum="A5DA4C3F18F4FD45" modified="2011-09-21" version="1">MKVKEKIQKITFINDAYTKWKWRERTVSYGNENPDKTFFVIRRATCKVGLFSHVMTNMGLVRYALENNYIPVIDMQSNLNSYLEESQVGKENAWEFYFEQPCGYTLEDISKSRRVILSDGLITKKNDYPDGQITFDSEKYRLWRDFFMKYFRIRTDIVRDVEQLRDDFFHGERVVGVLCRGTDYVAQHPKNHPIQPAISDLINKTIKTLLEYSCKWVYLATEDEDAYQKFLETFGDRLKITRAKRCKNIGNRNINEVSFGRKNDKYLRGREYLINILLLSECDCLVAGSAGGTYGALLIGKEYEYQYIYDLGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6A3</accession>
    <name>F7K6A3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251340.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01391"/>
    <dbReference type="EnsemblBacteria" id="EGN42253">
        <property type="protein sequence ID" value="EGN42253"/>
        <property type="gene ID" value="HMPREF0994_01391"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1511"/>
    <dbReference type="eggNOG" id="ENOG5032S2D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082665_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5672" evidence="1">
        <location>
            <begin position="90"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="254" mass="29485" checksum="3F9CD30C212FCE9F" modified="2011-09-21" version="1">MDDKKRSYYNAQGKLVLPQVTLCAMDSVQVRATLKAMEYSMKDIVFADAVIITDKKPLFMPKGIRYAHIDKLCNIDDFNYKTVYDLGDYIKTEFALLVHYDGFVVHPEMWRDEFLDYDYIGSPWPLPKPGDTTTYRDIHGNICRVGNSVGIRSKRLMDFPKKAGVPWVGEKGYFNEDGFICCKIRHLLEAEGMQIAPLEVAKYFGHENMIPETEGITPFVFHKWYGTNSGYPDFRRKNKLLHRLKKIHGRLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6B9</accession>
    <name>F7K6B9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251356.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01407"/>
    <dbReference type="EnsemblBacteria" id="EGN42269">
        <property type="protein sequence ID" value="EGN42269"/>
        <property type="gene ID" value="HMPREF0994_01407"/>
    </dbReference>
    <dbReference type="GeneID" id="29725723"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075575_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006998">
        <property type="entry name" value="DltD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04914">
        <property type="entry name" value="DltD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="355" mass="40872" checksum="EE225CB89BEC4DD4" modified="2011-09-21" version="1">MKSFLVKSVLAVCITVFCVFYLDIMYEQKSDNPIAEVNAFNFVPETIQLANFGSSHGQYAFDWGALKDRGIKCFNFALPSQSFEYDYALLNMHKDDFAEGSIAFIPVSYFSFNSEATSPDDIEAISVRYYRILSPQYNPNYSLYKDIVAIRFPILSAGDKIFDLFKPPITFPSLSDNRQNIVYAAEVSPGVPAQDENEDAVSTDLSSEVPVSAENLEQIYGAEKVQEFEAKGIARYQRHFEGKSEYFEEDKEQNLKKMIELCQERNITPILITTPFSIYYNKYVSEEFMNEFYSKIQGIASEYGVSYYDYSHDERFQMHLEYFGDADHLNEEGAIYFTDMLTNEIPELKAYLETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6C8</accession>
    <name>F7K6C8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_01366</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01366"/>
    <dbReference type="EnsemblBacteria" id="EGN42228">
        <property type="protein sequence ID" value="EGN42228"/>
        <property type="gene ID" value="HMPREF0994_01366"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1486"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="360"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="582" mass="66590" checksum="3F8138502FCE1FD4" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6J3</accession>
    <name>F7K6J3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_01501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251450.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01501"/>
    <dbReference type="EnsemblBacteria" id="EGN41975">
        <property type="protein sequence ID" value="EGN41975"/>
        <property type="gene ID" value="HMPREF0994_01501"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1638"/>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073546_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="10">
        <location>
            <begin position="59"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="33053" checksum="D144786ACC8C52EE" modified="2011-09-21" version="1">MRISTFFYTLKQGIINIFRNKWFSLASVATISACLFLFGLFYAVITNFQSIVKSAEEGVSVTIFFQPGTTEEQIMDIGSKIEARDEVSKIEYTSPEQAWEYYKENWIPEEFSDGFPDNPLENSASYAIYMKDISQQTALVDYLNSIPEIRTVNQSELAASTLTGVNALVAYVSAGIILILLLVSVFLISNTVTIGISVRKEEISIMKYIGATDFFVRAPFVIEGILIGVFGSALPLGTIYVLYNKVVEYIGTKFSVLSGLLNFLPVNTVFSTLAPVVIAIGVGIGFLGSFITVRKHLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6N6</accession>
    <name>F7K6N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stage V sporulation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251495.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01546"/>
    <dbReference type="EnsemblBacteria" id="EGN42020">
        <property type="protein sequence ID" value="EGN42020"/>
        <property type="gene ID" value="HMPREF0994_01546"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1686"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13124">
        <property type="entry name" value="MATE_SpoVB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="543" mass="58102" checksum="4653FCDEDB8797ED" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6R3</accession>
    <name>F7K6R3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cys_rich_VLP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251525.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01578"/>
    <dbReference type="EnsemblBacteria" id="EGN42052">
        <property type="protein sequence ID" value="EGN42052"/>
        <property type="gene ID" value="HMPREF0994_01578"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1725"/>
    <dbReference type="eggNOG" id="ENOG502Z9XT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116176_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025973">
        <property type="entry name" value="Cys_rich_VLP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14194">
        <property type="entry name" value="Cys_rich_VLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cys_rich_VLP" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="137" mass="15855" checksum="67C5A94243D68378" modified="2011-09-21" version="1">MRENPYKRLPPIERRQDGSLYRMTPAQRKQANALICRECCCYEDGNCMLLDDGDTHTCPQTISFSVCCKWFRWSVLPQIGTLEAEIFRDKELKRCAVCGGVFVPKSNRAKYCPGCAARVHRRQKTESERKRRSCVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Z3</accession>
    <name>F7K6Z3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01504"/>
    <dbReference type="EnsemblBacteria" id="EGN41978">
        <property type="protein sequence ID" value="EGN41978"/>
        <property type="gene ID" value="HMPREF0994_01504"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1641"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101299_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN41978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="25748" checksum="2172118E6DF8FD72" modified="2011-09-21" version="1">MQKYTILGITLYDYGAREALRNTDSFLHNGALNTIAYISSSNLAQASKDEQLKDCLEAIDMTVCTEPDVLEAAGIAGRNRIREIDEKVYLRELFRKFGRNRNSVYLLADTQDNLEVLQEIVSEYQDNLLIKGCGVYEDFGSQPERLVNNLNDLAPEVIISRMPWPTDVQLMHAYGHFVNAELWVSLPFGAVGWVRNPSLLARLKRKLVYQAFTHNVNEYNKKKTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K760</accession>
    <name>F7K760_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01689"/>
    <dbReference type="EnsemblBacteria" id="EGN41727">
        <property type="protein sequence ID" value="EGN41727"/>
        <property type="gene ID" value="HMPREF0994_01689"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1844"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="68"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="163" mass="18340" checksum="6E5F269C4D289EF9" modified="2011-09-21" version="1">MRELREQLLGIIEKNSRIDLKELAVILGVEEVDVVNELAAMESEGIICGYHTLIDWDKTSLDKISALIEVRVTPQRGQGFDNIAERVYKYPEVNAVYLISGGFDLLVTLEGRNLKEISSFVSEKLSALDGVLSTATHFILKKYKDHGTILAKKYEDSREKITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K779</accession>
    <name>F7K779_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251621.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01708"/>
    <dbReference type="EnsemblBacteria" id="EGN41746">
        <property type="protein sequence ID" value="EGN41746"/>
        <property type="gene ID" value="HMPREF0994_01708"/>
    </dbReference>
    <dbReference type="GeneID" id="29727536"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1868"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080906_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="257" mass="29044" checksum="70DBE51298F018BF" modified="2011-09-21" version="1">MKITWFGTASILLEAEGEKLLFDPFVQLAGGSNPNSLEDFPADTDICITHGHVDHLFFLPDLLAEQDITVYGTKAVMDTLEGWVEETGSLVQAEPGCSWRRGNMKITMLKGQHTRFTARMVLRKLINPRLFRYFRNTLFLAWAHPKFPEKGETVAYQIDAEGKRILLLGSMALDKNTIYPTNVDLLILPFQGRENMAEAAMEIVDELKPRRILLDHFDDAFPPVSEDVDTRPFKRAIALKHPEIKVVKPRAGKPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7C3</accession>
    <name>F7K7C3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN41565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01752"/>
    <dbReference type="EnsemblBacteria" id="EGN41565">
        <property type="protein sequence ID" value="EGN41565"/>
        <property type="gene ID" value="HMPREF0994_01752"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1913"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357161" evidence="5">
        <location>
            <begin position="32"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="447" mass="49338" checksum="85D1FED2597A915A" modified="2011-09-21" version="1">MKRIMSMLLSTALVFTLTACGSGNGDSQSSAVTETTQEMQKESTANEGENTASEENAKLKLMYWESAYTEPLKQAVAGFQESHPGVTVELEVPAGDYETVLLSRIMSDEAPDLFMYFGSSVFKMAQNGYWGSLDEGSAWVGDLNPSFKQNMTYEGTLYAYPLDCSGEGVFYNKKVFEDNGLKVPETYEDFLTVCDTLKSKGITPVALGAKDNWTSYHAFSSVVASFQTLYDEEFGTKLYDGETTFKDSRYKDAFEVMKELNDRGYFTEGTMGVDLNQAAQSVAAGEAGMLLLSSYAVSVFQDLDPNVEIGYFPFPNKEGESAVVAFVDKAIGYSPTSQNTEICKEFINYIAQPEVLSNMLEQIKTIPCADGIEYDMPAASRELYEAMKDHKVYAFFDSFWPGSCNTVVDKGITAILSGSGDIDQIISDMDSAYQEDKDSVIRPLLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7G1</accession>
    <name>F7K7G1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_01790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251703.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01790"/>
    <dbReference type="EnsemblBacteria" id="EGN41603">
        <property type="protein sequence ID" value="EGN41603"/>
        <property type="gene ID" value="HMPREF0994_01790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1953"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="7">
        <location>
            <begin position="273"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN41603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="514" mass="55417" checksum="5502AC291985DC16" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7J5</accession>
    <name>F7K7J5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1854 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01824"/>
    <dbReference type="EnsemblBacteria" id="EGN41637">
        <property type="protein sequence ID" value="EGN41637"/>
        <property type="gene ID" value="HMPREF0994_01824"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032H92">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121383_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015005">
        <property type="entry name" value="DUF1854"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08909">
        <property type="entry name" value="DUF1854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1854" evidence="1">
        <location>
            <begin position="59"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="193" mass="22622" checksum="1E18E7309B3DA145" modified="2011-09-21" version="1">MRHRNEVVMEDLFAEEFDLEQMEAETEAMLALNYLDRSNSTFHRTEGGFVSLDTQEKHYNRVQVFRTFPFTGKNMYISIREPDEKAKEIGVIHDLDKDVDEETRKMLTEQMELRYFTPIITKVKNVKEEYGFAYFDVVTDHGPCRFAIHMSGNAVVHLTETRLLITDLDENRFEIPDTSKLTGKELKKIGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7R5</accession>
    <name>F7K7R5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251873.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01960"/>
    <dbReference type="EnsemblBacteria" id="EGN41365">
        <property type="protein sequence ID" value="EGN41365"/>
        <property type="gene ID" value="HMPREF0994_01960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2153"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061999_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="28075" checksum="49A0B508883A69CC" modified="2011-09-21" version="1">MYQIKTDCHVHTILSGHAYSTIEECAVYAAEQQLECIAVTDHFCPIRAEEFGDKAVPFINLKVLPSHIRGVRILRGMEADILDLQGHLANYNVMHEGKSVLEEALKDMELVIASVHRGPGKMETDREDSAANTQMYMKVLNNSKVNVLGHVGRSVYRFEMLPVIREAGRLGKALEINEASFRFGEPITAVCRKAAQLCAQEGTSIMVNSDAHSAHAVGRYPETLRMIEEIHFPETLIANRDLETLEKFLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7U4</accession>
    <name>F7K7U4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251903.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01990"/>
    <dbReference type="EnsemblBacteria" id="EGN41395">
        <property type="protein sequence ID" value="EGN41395"/>
        <property type="gene ID" value="HMPREF0994_01990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2186"/>
    <dbReference type="eggNOG" id="ENOG502ZDSD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074054_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008875">
        <property type="entry name" value="TraX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05857">
        <property type="entry name" value="TraX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="275" mass="31687" checksum="6A4048F8CC970474" modified="2011-09-21" version="1">MKNEICKKGFTDFQLKWIALVLMVMDHIHYFFEFTGKIPEWFSMLGRLSAPLFLFCLLEGFQHTRNRKKYFLRIYAIAVGMGLLQYIFICFVRRPDGFVPQNQMLATFSILLVILQGIDWCKQKKWGRGLSAIVLPLIWPFVGMGLIQAVPSAANAVLLLHYTLLPMHSAIIDGGTYFILEGILLYLFRKRRALQAAVFFVLALILEGVFPFLLTPGATAEMLITTMYGWMSGFAAIPMYLYNGQRGKGNKKLFYWFYPAHVYILYGISWVMQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K834</accession>
    <name>F7K834_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251994.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02081"/>
    <dbReference type="EnsemblBacteria" id="EGN41486">
        <property type="protein sequence ID" value="EGN41486"/>
        <property type="gene ID" value="HMPREF0994_02081"/>
    </dbReference>
    <dbReference type="GeneID" id="29728081"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2284"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_3_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="96" mass="10722" checksum="E29F84C2AC57E991" modified="2011-09-21" version="1">MKRCNLLFIMTDEQRFDAVGYQNPCVKTPNLDALAEESVVFDYAYTTNPSCIPARAAIFTGRYPSQCGAPCYITPLPKKETTFMKLLQEGGYVQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8D5</accession>
    <name>F7K8D5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251826.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01913"/>
    <dbReference type="EnsemblBacteria" id="EGN41318">
        <property type="protein sequence ID" value="EGN41318"/>
        <property type="gene ID" value="HMPREF0994_01913"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2096"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="205"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="35214" checksum="6689CE8D06EA72ED" modified="2011-09-21" version="1">MHYLDYNEKIEHGTPDFPIAFYHVDEHHSRYNMPFHWHKEMELIQVQSGSLRLFLDDREILAGAGDVILIEEGVIHGGIPEHCVYECAVFDLKSTLMHTDACKRYIRLISRHQIQLYNYFQAVPREGTVRDPSVLPGAAPSSRDNSRLLQAVRRLFDAIRYPHAGSELSTLGALYEIFGCLFEEEYYIPVTDAPAPGQKKMDQLKPVLEYIDSNYSSPVTLADLSRIAGMTPKYFCRYFRAAIHRTPMDYLNYYRIERACYILSTTELPITDVAYQCGFNDSSYFVKTFKKYMDVTPKQYALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8E0</accession>
    <name>F7K8E0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LPD34 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02120"/>
    <dbReference type="EnsemblBacteria" id="EGN41027">
        <property type="protein sequence ID" value="EGN41027"/>
        <property type="gene ID" value="HMPREF0994_02120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2322"/>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014281_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040672">
        <property type="entry name" value="LPD34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18852">
        <property type="entry name" value="LPD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD34" evidence="2">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="278" mass="31615" checksum="971315727ACEC92A" modified="2011-09-21" version="1">MEENKDYQVYRFDYLTEGSQLKLEHNVYCEDVDISSLITQGADALEALRQDSIDGEQKALAIVQAAAKQWEQQAAVTQKLNRSLEYLRTPEVAHTGNEWRKTGNWRDAEEISNRVYKMTCSVWEDTKYDRETKQSVPVAWYVTWDVYVNSPKEGYGEKIAGQNQKRYTDKAAAMKYLDGRKKAYSHLFTEISPQIPKEYEHHFTVHGTLLPGYTVEGQEPVKAEHTAAEVSEGDISLPEKAEKPSVLGKLAAAKLDAKESGQPVRQGEKYQSEERSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8K7</accession>
    <name>F7K8K7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cys_rich_VLP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002593312.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02195"/>
    <dbReference type="EnsemblBacteria" id="EGN41102">
        <property type="protein sequence ID" value="EGN41102"/>
        <property type="gene ID" value="HMPREF0994_02195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2401"/>
    <dbReference type="eggNOG" id="ENOG5031IBG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116176_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025973">
        <property type="entry name" value="Cys_rich_VLP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14194">
        <property type="entry name" value="Cys_rich_VLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cys_rich_VLP" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="122" mass="14103" checksum="2738C72DEB51F202" modified="2011-09-21" version="1">MSNNYRELTGREKQRIKKLVTSLCANYDKEYGCLPLDCDCPMLGICFTNSALCRYFRKSVLPEDAGLEAVFTQISTTHCKQCGKPFPTDGKRVYCSQRCAEEARRKQTAARVRKYREKQQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9B3</accession>
    <name>F7K9B3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.399</ecNumber>
            <ecNumber evidence="7">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0994_02462</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="6"/>
    <dbReference type="EC" id="1.1.1.95" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252363.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02462"/>
    <dbReference type="EnsemblBacteria" id="EGN40861">
        <property type="protein sequence ID" value="EGN40861"/>
        <property type="gene ID" value="HMPREF0994_02462"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2699"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_9_0_9"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="13">
        <location>
            <begin position="318"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN40861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="41820" checksum="9543ECAB0E4453F5" modified="2011-09-21" version="1">MFKYHCLNPIAKVGLDGFTEEYVKTEDIGEADGILVRSAAMHDMDLPDNLLAVARAGAGVNNIPLDKCASKGIVVFNTPGANANGVKEIVIAAMLLASRDIVGGINWVEANKDNPNIAKDAEKVKKNFAGTEVQDKKLGIIGLGAIGVKVANVAKHMGMEVYGYDPYVSVDAAWNLSRDVKHVINVDEIYENCDVITIHVPLLDSTREMINEAAIAKMKEGVILLNFARDLLVDEEAVLAGIEQGKVRKYVTDFPNLTTAGKPGCIVIPHLGASTEESEDNCAVMAVKELKNFLENGNINNSVNYPSCDMGICDQAGRIAIFHLNVANMITKFTALFGDNGINISDMTNKSKGDVAYTMMDVETPPSEEIINTLRSIPGVIRVRVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9P7</accession>
    <name>F7K9P7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02578"/>
    <dbReference type="EnsemblBacteria" id="EGN40977">
        <property type="protein sequence ID" value="EGN40977"/>
        <property type="gene ID" value="HMPREF0994_02578"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2824"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_6_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="368" mass="40450" checksum="F6A6E3DFEB7C461F" modified="2011-09-21" version="1">MENVRIGILGLGAISGIYLKNLTGLFRETEVVGIYDLIPEKMEQAQKEYGIPKAYSSMEEMFQDKDIEIILNLTRPFEHYETTKAALLAGKHVYSEKPLAATFEEGKELVALAQEKGLLLGGAPDTFLGAAVQTCRKLIDDGFIGRPIGATAQMICHGHESWHPSPEFYYQYGGGPMMDMGPYYMTALVNLLGSAKGLTGLVTKSFETRTITSEPKCGTVVPVEVPTHVNGILQFTNGAVATVTTTFDVYYDRQDKLEIYGTEGTLRVPDPNGFGGSITLLRPEEGSFKEIPLVFDYQDNSRGLGVADMAKALRCGRGCRADCSQTLHVLEIMTAFEKSSREGRYMELETSYERGPAMAHNPVRGILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9R2</accession>
    <name>F7K9R2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252492.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02591"/>
    <dbReference type="EnsemblBacteria" id="EGN40574">
        <property type="protein sequence ID" value="EGN40574"/>
        <property type="gene ID" value="HMPREF0994_02591"/>
    </dbReference>
    <dbReference type="GeneID" id="29726172"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013716_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032250">
        <property type="entry name" value="DUF4825"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16107">
        <property type="entry name" value="DUF4825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="3">
        <location>
            <begin position="10"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4825" evidence="4">
        <location>
            <begin position="348"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="651" mass="72575" checksum="8E318A9CBC101BE7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9S1</accession>
    <name>F7K9S1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_02602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252503.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02602"/>
    <dbReference type="EnsemblBacteria" id="EGN40585">
        <property type="protein sequence ID" value="EGN40585"/>
        <property type="gene ID" value="HMPREF0994_02602"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2851"/>
    <dbReference type="eggNOG" id="ENOG502Z9QV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331109_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025466">
        <property type="entry name" value="DUF4317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14199">
        <property type="entry name" value="DUF4317"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="208" mass="23903" checksum="A236F9807E279BA7" modified="2011-09-21" version="1">MINREDMLELTRRMTLARTSFSRIAGCYIDKDGDFEGSFNTNFLKLSAAEKTKKLKLAKAIPYSETNVNLKKYEIPQSMQKPGSMWQLLMTMNECGLKNDALMDTFYDIVMESYRSDSEYAILVFHGRYDIPLKAADKVGLWESEEVFEYMICAICPLEGEYEPGDPECGFLFPAFTDRSRDLDHIAVFQADTDRPHDEILKILGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA96</accession>
    <name>F7KA96_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_02946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252847.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02946"/>
    <dbReference type="EnsemblBacteria" id="EGN40555">
        <property type="protein sequence ID" value="EGN40555"/>
        <property type="gene ID" value="HMPREF0994_02946"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3214"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="80"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="179" mass="19203" checksum="95F81471E9B6E280" modified="2011-09-21" version="1">MYYSTTCSSPVGMLTLASDGNNLTGLWIEGQKYHGNTMAGEMVENKEIPVFEQTRKWLDNYFAGGKPAVSEIPLAPAGGEFRQEVWKILCQIPYGSVITYGDIAKLIAEKRNRPGMSGQAVGGAVGHNPISIIIPCHRVVGSNGSLTGYAAGIDKKIQLLKLEGVDMSSLFVPQKGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAD2</accession>
    <name>F7KAD2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252659.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02758"/>
    <dbReference type="EnsemblBacteria" id="EGN40367">
        <property type="protein sequence ID" value="EGN40367"/>
        <property type="gene ID" value="HMPREF0994_02758"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3017"/>
    <dbReference type="eggNOG" id="COG3874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115880_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014229">
        <property type="entry name" value="Spore_YtfJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09579">
        <property type="entry name" value="Spore_YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="136" mass="14214" checksum="DC118101D2C4717C" modified="2011-09-21" version="1">MADNNNGINSVMESLLKGANALMSTKTVVGEATKIDDTIIVPLVDVSFGVGAGASRNGGKDGGAGGLSGKMTPSAVLLIKNGQTKLVNIKNQDSVTKILDMIPDLVDKFTTKEEPMMSDEDAEKAAFPDEDEDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAH0</accession>
    <name>F7KAH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252697.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02796"/>
    <dbReference type="EnsemblBacteria" id="EGN40405">
        <property type="protein sequence ID" value="EGN40405"/>
        <property type="gene ID" value="HMPREF0994_02796"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3062"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="336" mass="36872" checksum="5B30DF49D7CC45B2" modified="2011-09-21" version="1">MEAENKNVVLEIKDLSITIKLDEGTLTPVRGLSLAIGKGETLGLVGESGCGKSLTSKAILGINTPNCKTLGQIMFRENGKSMDLLKMRPGGKEIRNIRGNRISMIFQEPMTSFSPLYTVGNQLSEAVAVHSKKDKKKAREIVVETMKKVGIPNPEKRFDQYPHEFSGGMLQRALIAMALLCSPGLLIADEPTTALDVTIQAQILELMRSLQKDYGMSILYITHDLGTVAQMCDRVAVMYLGQIVELAEVHEIFNHPLHPYTRGLMGSVHKIGGGKERLFSIEGTVPLAMNLPDRCGFYERCGHRSEKLCCGCAPVLTEVTPGHYAACLMPQEEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KB77</accession>
    <name>F7KB77_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">HMPREF0994_03116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253017.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03116"/>
    <dbReference type="EnsemblBacteria" id="EGN40293">
        <property type="protein sequence ID" value="EGN40293"/>
        <property type="gene ID" value="HMPREF0994_03116"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3407"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="123"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="321"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN40293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="406" mass="45930" checksum="88AD9714F6878C77" modified="2011-09-21" version="1">MKNVYTVAQVNSYIKNMFSQDFMLQNIYVKGEVSNCKYHSSGHIYFTIKDAKGTIACVMFAGNRAGLKFRMEEGQQVVVGGSVEVYERDGKYQLYAREIILDGAGYLYEKFERLKRELLEQGLFASEYKQPLPKYIRTLGVVTAPTGAAVQDIINITRRRNPYVQIILYPAIVQGEQAAASIIRGIRALEHIGVDVMIVGRGGGSIEDLWAFNEEAVAQAVFDCTVPIISAVGHETDTTIIDFVSDLRAPTPSAAAELAVYDIRQLEALLEGCRNDLNARIRNRIEWERSKIRQVRTKLQYLSPANQIREKRMYALRMEEQLSALMKQRLMEKRHMLGLYTEKLKGLSPLDKLNQGFSYVSDSEGKTVSDVKRVAVGDRLSIHVKNGKIETLVTDKELWKKEKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBB2</accession>
    <name>F7KBB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="10" type="ORF">HMPREF0994_03141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253042.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03141"/>
    <dbReference type="EnsemblBacteria" id="EGN39971">
        <property type="protein sequence ID" value="EGN39971"/>
        <property type="gene ID" value="HMPREF0994_03141"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3434"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1" evidence="8">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="9">
        <location>
            <begin position="232"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="9">
        <location>
            <begin position="303"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN39971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="420" mass="47299" checksum="77D34700189CE868" modified="2011-09-21" version="1">MNKELMEALDILEKEKEISKETLFEAIENSLLTACKNHFGKADNVKVEIDRKTCDFLVYAEKEIVATHEEVEDDCLQIALEDALEISKRAKVGDVIHVEIKSKEFGRIATQNAKNVILQKIREEERSVIYNQYFEKEKDVVTGVVQRYVGKNISINLGKADALLNESEQVKGEVFKPTERIKVYILEVKNTPKGPRILVSRTHPELVKRLFESEVTEIKDGTVEIKSIAREAGSRTKMAVWSNNPNVDAVGACVGMNGARVNAIVDELRGEKIDIVNWDENPGNLIQNALSPAKIVAVFADPDEKTAKVVVPDYQLSLAIGKEGQNARLAARLTGYKIDIKSETQAKDAPGFRYEDYLDDEYDEEEGEFEEEYEDGYEEAGEELSEEGSAEAPEEETFDEELDEETSEETLTEDNGENYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBE0</accession>
    <name>F7KBE0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03174"/>
    <dbReference type="EnsemblBacteria" id="EGN40004">
        <property type="protein sequence ID" value="EGN40004"/>
        <property type="gene ID" value="HMPREF0994_03174"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131453_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="117" mass="13646" checksum="21BF16A0015CE224" modified="2011-09-21" version="1">MNEENKKLLLEAGVDLDRTMERFMNNEGLYLKFLKRFPEDPNFAQMKENIAGGQYEEAFKNAHTLKGLSGNLGLEAFYQTISVLTEQLRNKNLDHLEESMRDAEDIYKMLIQKISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBE9</accession>
    <name>F7KBE9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40013.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360256.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03183"/>
    <dbReference type="EnsemblBacteria" id="EGN40013">
        <property type="protein sequence ID" value="EGN40013"/>
        <property type="gene ID" value="HMPREF0994_03183"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="5">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40013.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="203" mass="22790" checksum="05D952766A563876" modified="2013-09-18" version="2">MNQKERMLAGLPYKAWLDGLSEERMENKKRIYRYNSLSPEQGEEQAALIKEIIGKCGENIWIETPFHCDYGWNIEVGENFFANYNLTILDVGKVVIGKNAQIAPNVSIYTAGHPVHPDSRNTGYEYGIGVTIGDNVWLGGNTVINPGVTIGNNVVIGAGSVVTKDLPDDVIAVGNPCRVLRKITEEDRKYYFKDREFDVEDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBL7</accession>
    <name>F7KBL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN40084">
        <property type="protein sequence ID" value="EGN40084"/>
        <property type="gene ID" value="HMPREF0994_03254"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3169378_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="47" mass="5463" checksum="BE4B464DBB600E71" modified="2011-09-21" version="1">MSSENIDIDTGDARWFGEYDTYEIAYDFNEEYGKKNGNKKNYNELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBN9</accession>
    <name>F7KBN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253177.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03276"/>
    <dbReference type="EnsemblBacteria" id="EGN40106">
        <property type="protein sequence ID" value="EGN40106"/>
        <property type="gene ID" value="HMPREF0994_03276"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3580"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="13"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="556" mass="63449" checksum="DC13124F79E94FBD" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC95</accession>
    <name>F7KC95_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253375.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03474"/>
    <dbReference type="EnsemblBacteria" id="EGN39547">
        <property type="protein sequence ID" value="EGN39547"/>
        <property type="gene ID" value="HMPREF0994_03474"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796455_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="352" mass="39849" checksum="866A84228E2492F0" modified="2011-09-21" version="1">MSLKDGMAAICLEMPDKVPRTEYSADFHWELVSKVTGIEVDSKSPSEIQNRAASAFRREWDYGFVWNTLIGADALDSCRTRMGHAEYAAGGTDYSTRVECPFGDPEEAFDFSPEEVYGLPDEKQLTAQFNEDYRRKMEATPDAVNTTGVYITMISGLLEIFGWDILLMAMGIDAKAFGETANRYGTWIQHYFNALARCDAPVVKVHDDITWTSGAFARPDWYREFIFPNYKRLFAPLREAGKKIIFTSDGNYTEFIDDIADCGVSGFVMEPSTDMKYVAEKYGKTHSFIGNADTRILLSGSREEIYSEVKRCMDIGKACPGFIMAVGNHIPPNTPVENCLYYNEVFEKLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCI3</accession>
    <name>F7KCI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253468.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03567"/>
    <dbReference type="EnsemblBacteria" id="EGN39476">
        <property type="protein sequence ID" value="EGN39476"/>
        <property type="gene ID" value="HMPREF0994_03567"/>
    </dbReference>
    <dbReference type="GeneID" id="29728160"/>
    <dbReference type="HOGENOM" id="CLU_1119036_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="248" mass="27482" checksum="B2A94B5558473242" modified="2011-09-21" version="1">MRKIHVILLAVFTTGVLCGGIGTGIAFGEYSSMEYGGTVMLGEEYLVTGELMYEFDPVPGEKIALNPTNWGTSRGTSNLVMDETLPMGTVCYDVTYNSKLTIPHLYYWESEEGLEEEDIFEAGEAETGNGMEINEASIDEAEAGEEADAGEEADVGEETDAGEKADAAEEAVTGETAEEKKKSRVVGHLELGTNYIGNEFELFLRSKDRILEDMKNKKFNSFETAYITDVKIRVNPEMMDYIEDRTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCU9</accession>
    <name>F7KCU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39050">
        <property type="protein sequence ID" value="EGN39050"/>
        <property type="gene ID" value="HMPREF0994_03678"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3136932_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="49" mass="5688" checksum="73EDEF4424A16BC8" modified="2011-09-21" version="1">MTNSKTIENAKMLHGIEEELHTFAKWKELGYIPQKGQHAIIKKAMEISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDB7</accession>
    <name>F7KDB7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253749.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03848"/>
    <dbReference type="EnsemblBacteria" id="EGN38613">
        <property type="protein sequence ID" value="EGN38613"/>
        <property type="gene ID" value="HMPREF0994_03848"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4189"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN38613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="139" mass="16054" checksum="5CF1B35CB65E2751" modified="2011-09-21" version="1">MLMPSIFGEDLFDDWMRFPFGSYNESSLMKTDIRDNDGHYELDVDMPGFSKEDIKVELKDGYLTISASTKKDNDEKDENGKYIRRERYMGSCSRSFQVGDSVKQEDIKAKFENGILKLTVPKEEAQPKVEENKYIAIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDF9</accession>
    <name>F7KDF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbrB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253793.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03892"/>
    <dbReference type="EnsemblBacteria" id="EGN38657">
        <property type="protein sequence ID" value="EGN38657"/>
        <property type="gene ID" value="HMPREF0994_03892"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4236"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="75" mass="8214" checksum="9CA0A412BEF99FD4" modified="2011-09-21" version="1">MAKLKPPEGKFVASIKVGPKGQIVVPKEVRDMFGIEPGDMLLLLADEAQGIGILPFNSTVQLFDDVFSKKEPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE45</accession>
    <name>F7KE45_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254025.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04124"/>
    <dbReference type="EnsemblBacteria" id="EGN36917">
        <property type="protein sequence ID" value="EGN36917"/>
        <property type="gene ID" value="HMPREF0994_04124"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4496"/>
    <dbReference type="eggNOG" id="ENOG50319EX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118991_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="123" mass="13854" checksum="DFE434F98C2E3103" modified="2011-09-21" version="1">MNTYTETEKEQALGVIESAVGRCEKVWPKFAEGTSQHSLLKNRIKALYIAKALISGEEKRDGYGKEELQQALAPIESIISKCEKARLKFEDGSAHYVRFSNMIEAMDIAKAYIRDAINNRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE90</accession>
    <name>F7KE90_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium ion-translocating decarboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254070.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04169"/>
    <dbReference type="EnsemblBacteria" id="EGN36962">
        <property type="protein sequence ID" value="EGN36962"/>
        <property type="gene ID" value="HMPREF0994_04169"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4544"/>
    <dbReference type="eggNOG" id="COG1883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036168_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018801">
        <property type="term" value="F:glutaconyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="379" mass="40338" checksum="C3353E3040FFBD02" modified="2011-09-21" version="1">MEFIYEGLLSITPQQVIMYLVGLLLIYLAIKKEYEPALLLPMGFGAILVNLPLSGVINQTMPGIGEVNGIIEWLFNVGIEASEALPILLFIGIGAMIDFGPLLSQPIMFLFGAAAQFGIFFAICAAALMGFDLKDAASIGIIGAADGPTSILVSQVLGSRYVGPIAVAAYSYMALVPIVQPFAIRLVTTKKERLIRMPAKPSRPVTKTTRILFPIIVTFLVGLISPASVSLVGFLMFGNLLRECGVLGNLSETAQTSLANLITLLLGITISFSMRADAFVRFDTLLIMIIGLLAFVFDTIGGVLFAKVLNLFRKEKINPMIGAAGISAFPMSARVVQKMAMKEDPGNILIMQATGVNVSGQIASVIAGGLVISLVSAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEE0</accession>
    <name>F7KEE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04219"/>
    <dbReference type="EnsemblBacteria" id="EGN36499">
        <property type="protein sequence ID" value="EGN36499"/>
        <property type="gene ID" value="HMPREF0994_04219"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3062703_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="53" mass="6583" checksum="5A64330BB362C32D" modified="2011-09-21" version="1">MIPDQDVKDRMHYFLYETNLYRRILRSGFDFISRPLFLNLYIAKCDYQLYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEG1</accession>
    <name>F7KEG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254144.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04243"/>
    <dbReference type="EnsemblBacteria" id="EGN36523">
        <property type="protein sequence ID" value="EGN36523"/>
        <property type="gene ID" value="HMPREF0994_04243"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4635"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="162" mass="18113" checksum="2DFD9198E9B1F98C" modified="2011-09-21" version="1">MLTQEEITSLDEILSSHDYDSSSVIAVMQDIQKKYRYLPEDALTYIAGKLKLSEAKIYGVATFYENFSLEPKGRYVIKVCDGTACHVRKSIPILEEFRNILGLSETKHNSDDMLFTLETVSCLGACGLAPVCTVNDKVHAAMTPEKARELIKELMEEAANEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEP1</accession>
    <name>F7KEP1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EGN36023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254221.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04320"/>
    <dbReference type="EnsemblBacteria" id="EGN36023">
        <property type="protein sequence ID" value="EGN36023"/>
        <property type="gene ID" value="HMPREF0994_04320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4717"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357325" description="DUF3502 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="2">
        <location>
            <begin position="409"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="548" mass="61391" checksum="181B04BD8EF35911" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEV1</accession>
    <name>F7KEV1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254288.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04387"/>
    <dbReference type="EnsemblBacteria" id="EGN35697">
        <property type="protein sequence ID" value="EGN35697"/>
        <property type="gene ID" value="HMPREF0994_04387"/>
    </dbReference>
    <dbReference type="GeneID" id="29727014"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="12"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="326" mass="36525" checksum="754E3F93C4E95594" modified="2011-09-21" version="1">MRLGKSDIETKPIGLGCWAIGGQFRDMGAAAGWGDVEDSVSRKALNTGLEMGVQLLDTANIYGAGHSEKLIGQVMKGKRDKVIVATKFGILCDEGKKCTTGHISDRDDIRKSCDESLRRLGTDYIDIFHFHLGDFQPDDAVWVRDALEDLVKEGKIRYYGWSTQDTERARIFAEGEHCISMEFAENVMEDNPEMRFFCSESKLCAICRTPLAMGLLTGKYNSGSVFGQGDLRGKDAPPWMNYYINGKPNEVFLKKLEAIREILTSEGRTLAQGCIAWIWGMDSNCMPIPGFKNEKQVVENLSALEYGPLKEKEVIQIRNILEKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF56</accession>
    <name>F7KF56_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04498"/>
    <dbReference type="EnsemblBacteria" id="EGN35808">
        <property type="protein sequence ID" value="EGN35808"/>
        <property type="gene ID" value="HMPREF0994_04498"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="8"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="345" mass="37688" checksum="7A7C6E9C4266A605" modified="2011-09-21" version="1">MRALRLFGAGDIRLVEIPEPQITEEEILLKTDAAAVCGTDIRMWKNGHKGVDAEHPLTLGHEFSGTIVETGTKVPFYKKGMKVAMQPNIGCGICDRCVSGAFHLCESYKAFGINMDGAFAEYVRIPAEAVIRGNLMVLPEGVTPQEAAVVEPLSCAYNGFTKCHVKPGEKAMVVGAGAIGMCHAMLLHMAGARVLVNDIQEERLAYCKSIFPFIDTYTGGELPEYVRNWTGGRGLDVAVVACPAPQAQAMMPELMNIGGRINFFGGLPAEKEPVSIDTNQVHYKELYLTGSTRSSIAQFRKTMEFVAENLLNVKLLITDCYSLEEAMTAFDKAARAQGIKHVFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF89</accession>
    <name>F7KF89_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_04386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254287.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04386"/>
    <dbReference type="EnsemblBacteria" id="EGN35696">
        <property type="protein sequence ID" value="EGN35696"/>
        <property type="gene ID" value="HMPREF0994_04386"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4785"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="316"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="413"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN35696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="582" mass="66619" checksum="2BBC9129705F6912" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFC4</accession>
    <name>F7KFC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04553"/>
    <dbReference type="EnsemblBacteria" id="EGN35322">
        <property type="protein sequence ID" value="EGN35322"/>
        <property type="gene ID" value="HMPREF0994_04553"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4970"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="313" mass="35755" checksum="1CC7C0EA4E36340E" modified="2011-09-21" version="1">MHGVKVKTGTAGKNRSSKKYQLFFMVFPFLILLFLFSYLPLYGWVYSFFDYRPPKSLSDCAFVGIDWFRSMVSTPEKRLQLWEVLRNTFVMSGLGLLTSWMPMAFAILLSEIRNRHFKKAVQTLTTIPNFISWVLVYSMAFSLFSTSGMMNTFLQQLGILSKPVQFLQDNTHTWLSMWLWGQWKGLGWGAIMYLAAISGIDQELYEAARVDGAGRFRLIWHITVPSLLPTFFVLLIMNVANFLNNGMDQYFVFQNAFNTSKIQVLDLYVYNLGIKAGNYSLATAISMLKSIVSVTLLFTVNGISKVLRGESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFV5</accession>
    <name>F7KFV5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_04734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254635.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04734"/>
    <dbReference type="EnsemblBacteria" id="EGN34660">
        <property type="protein sequence ID" value="EGN34660"/>
        <property type="gene ID" value="HMPREF0994_04734"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5167"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="260" mass="30303" checksum="22D074DEB2C89BCF" modified="2011-09-21" version="1">MDTYSVYLVDDEPWALVYLEKIVKWEEMGFRITGKFENSVEAFNRAAAEPPDVIFIDIRMPELDGLAFMHKALEAKLPCRFVVISGFAEFGYAQEAIRMGVVYDYCLKPIARDKLTLLLDKLHGILEETKEQKQEKEEIPLAENPVFQEMLTFMHTHFREKLVLRELADQFHLNANYCCALFNKETGGSFSEYLASIRMKEAERLLTHTTLSLEEIAVQCGIQDYYYFNKVFKKYSGETPSQYRRQRRNTGNRNTDEGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG05</accession>
    <name>F7KG05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254685.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04784"/>
    <dbReference type="EnsemblBacteria" id="EGN34411">
        <property type="protein sequence ID" value="EGN34411"/>
        <property type="gene ID" value="HMPREF0994_04784"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5226"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087860_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="203" mass="22642" checksum="DEA1A1A6C441BD56" modified="2011-09-21" version="1">MNQYSDLDEISRDFLRELGNIGTGNAVTSLSHMLMEPVDIEVPGLQIMKYQDCCSLLPEAEELMTGIIVGVRGELNGLFLFLLDETFTREVLDTVLGEEERNLLSLDEMERSLICELGNIMCGSYICALSGVLDLKMEVTVPSMSIDMGLAILSVPVAHYSRVSEDILVIDNIFRMGGKAFSGRILFLPEPEALEMMLQRLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGC7</accession>
    <name>F7KGC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254807.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04906"/>
    <dbReference type="EnsemblBacteria" id="EGN34196">
        <property type="protein sequence ID" value="EGN34196"/>
        <property type="gene ID" value="HMPREF0994_04906"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5356"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="234" mass="26068" checksum="F019744D0EDFF52E" modified="2011-09-21" version="1">MLEELKKRVYEANMLLPRHGLVTFTWGNVSEIDRESGLFAIKPSGVDYDKLTPEDMVIVDLNGNKVEGKYNPSSDTATHVELYKAFPEIGGIVHTHSSYATSWAQAGRSIPCYGTTHADYIYGEVPCLRCLTKEEIEDAYEENTGHLIVNEFKAMGKDPKAVPAVLCKNHGPFSWGKDAHEAVHNAVVLEEVAKMAYRAEAINARIQPAPQELQDKHYFRKHGANAYYGQNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGH4</accession>
    <name>F7KGH4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254854.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04953"/>
    <dbReference type="EnsemblBacteria" id="EGN34122">
        <property type="protein sequence ID" value="EGN34122"/>
        <property type="gene ID" value="HMPREF0994_04953"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5409"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="7"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="33060" checksum="F9D97994F9F3C96E" modified="2011-09-21" version="1">MGKTAFIFPGQGSQYVGMGKDFYEKFPAARDIFDKASEASGLDVAALCFEENEQIHITEYTQIAMLTVEVALLKVLEEMGYRPDAAAGLSLGEYAALAAADVMDVKDLFYCVRKRGIFMQEAVPTGGAMTAILGLDSETIAKACEETDGIVSVANYNCPGQTVITGEAGAVNAASERLKELGAKRCVPLKVSGPFHSPMLKGAGEKLGQVLADISLKEIHVPYLSNVTGDYVADTSQVKELLVKQVSSSVRWQECVERMIADGVDTFVEIGPGKSLSGFMRKINRDVTVINVEKAEDLEKLPLSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGU9</accession>
    <name>F7KGU9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254979.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05078"/>
    <dbReference type="EnsemblBacteria" id="EGN33111">
        <property type="protein sequence ID" value="EGN33111"/>
        <property type="gene ID" value="HMPREF0994_05078"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5549"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063834_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="37"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="372" mass="44493" checksum="CF45B92344E942FB" modified="2011-09-21" version="1">MYFFILILLFILLFQVSSSGPEHFQEEHFTKNFELPLRGFFTLVIVYHHLSQYLDNPGPFRVFLEVGILCVAAFFFYSGYGLMKSVLTNKNYFHHFFLRRYIKIFVPFFICNALYLFVYYLTGDRYGLKLSLEYLSGIQLINPQSWYIIVIALFYFVFFLSFRFIRKKGISFLLLGIFQIVFPTYCMAKGPGIYWFQGEWWFNSSSLFFIGILMAQFEKPIMKFTRKWYYWLLLLSAGTFLYFFPKSVQVLDQIEPLLTNEHIFVKEMIGNWICFIWQTIAVINFMIFVFLLTLKIRFSNKFLSFLGTRSFEIYLIHGLFLEVFRSDRFYIQSDFLYTAAVLVLSLGCASLMYYPFKMISRKLEEYSLQLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHJ5</accession>
    <name>F7KHJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255167.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05324"/>
    <dbReference type="EnsemblBacteria" id="EGN33059">
        <property type="protein sequence ID" value="EGN33059"/>
        <property type="gene ID" value="HMPREF0994_05324"/>
    </dbReference>
    <dbReference type="GeneID" id="29727320"/>
    <dbReference type="HOGENOM" id="CLU_1747283_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="149" mass="17259" checksum="A7B787885F40157A" modified="2011-09-21" version="1">MYDTHYFTLHKTCPCQIDNEVVRKTKEIFNKSSCLTDFVAEMQNQQIIGRLISYDKETNTIFIHKRYACECGGGHPQNKTRIGERCHCGHYNHSTAYCPKYYCKCGAEFFRPVFAPLFGEDILIEPYKTVLSGDDECIIAIRINEREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHT7</accession>
    <name>F7KHT7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin reductase</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255269.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05426"/>
    <dbReference type="EnsemblBacteria" id="EGN32867">
        <property type="protein sequence ID" value="EGN32867"/>
        <property type="gene ID" value="HMPREF0994_05426"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5931"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="301" mass="31876" checksum="A804B7CEC3CF4E64" modified="2011-09-21" version="1">MHDLIIIGSGPAGLSAAVYGRRAGFSTLVIEKNPMSGGQVLNTYEVDNYLGLPGINGFDMGMKFREHAEKMQAEFIEADVLGVEDMGDYKLVKTTDGDYEAKAVIIASGASHSHLGVPGEEELSGMGVSYCATCDGAFFRGKTVAVIGGGDVAVEDAIFLARACEKVYLIHRRDSLRAAQSLQDTMLALPNVEVCWNSVVESINGEGRVNSITLVHKNGGTKSELAVQGVFIAVGIKPNSESFITNIAADEKGYLIAGEDCATSMPGVFAAGDIRTKKLRQIVTAVADGANAVEGIQEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHX6</accession>
    <name>F7KHX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin Q/BCP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255310.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05467"/>
    <dbReference type="EnsemblBacteria" id="EGN32908">
        <property type="protein sequence ID" value="EGN32908"/>
        <property type="gene ID" value="HMPREF0994_05467"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5976"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="150" mass="16840" checksum="7AE13849F50273E3" modified="2011-09-21" version="1">MLETGIKAPEFTLKNQDGEEVSLKDFLGKKVILYFYPKDNTPGCTTQACSFGDMYPQIREKGAVVLGVSKDSVASHKKFADKYGLPFTLLSDPELEAIQKYDVWQEKNMYGKKVMGVVRSTYLIDEEGIIKEAFTKVKPGENAVQMLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI83</accession>
    <name>F7KI83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05562"/>
    <dbReference type="EnsemblBacteria" id="EGN32387">
        <property type="protein sequence ID" value="EGN32387"/>
        <property type="gene ID" value="HMPREF0994_05562"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6078"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="464" mass="50930" checksum="9DEF8DF0FF9251EB" modified="2011-09-21" version="1">MRKDGMHLNRKLRLYLGTAEFYKRVGIIAIPIALQSLISIGVNMMDTVMLGALGEVALSASSLANQFINIYHVCCMGIGMGASVMVARFWGMQDSCSLKQSITIMLRLCIVFGLLFMAATILAPGALMRIYTPDADIIREGIRYFNWSVPTYLLLGLSLTCTIVLRSVGQAKVPLICSSVSFMANLFFNWVFIFGNLGAPRMEVAGAALGTLLARIIEFSAIAIYFFLRDKNIGYRIKDLFMDCHGLVPEYLKICIPVLISDSLLALGNSAIAMIMGRIGAAFVSANSITAVTQQMTTVLTQGISQAGCIITGHTLGEGKREQAQREGYTFLIFGALLGVAACVVILAISGPVIGMYHIQDETRRIAEQLMESVAVILIFTSANSILTKGVLRGGGDTKFLMFADILFLWLASVPLGILAGLVWKMPAFWIYFFMKIDQIIKCVWCVWRLRSGKWIKAIKKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIC2</accession>
    <name>F7KIC2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05601"/>
    <dbReference type="EnsemblBacteria" id="EGN32312">
        <property type="protein sequence ID" value="EGN32312"/>
        <property type="gene ID" value="HMPREF0994_05601"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6118"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="323" mass="35834" checksum="B7D6C48E2A5BBFFF" modified="2011-09-21" version="1">MKSVSRKNYGGTDGGQYNRGFLQEIRKNAFLYAMTVPGILFFLIFSYLPMAGLIIAFQNFNVKEGFMSPFCGLDNFKFFFNRSIFPGLSKAAVNTLWLNSLFIIATTAASVILALAFSEVRNKKYSRITQTCSLLPYFISWTIVSLFLNNVMLNSSNGVLSGFLRGIGLEVNFYSQAGVWPPLLIGMKVWQGAGYGSIVYLATITGIDPQIMEAAEIDGATRWDRIRYITLPILRPTIVLMTLFSVGKIFYGDFGMIYALVGDNSMLYPTTDVVDTYVYRAMRNLGQYGLSTAIGMIQSILGFALVIAANGIARRLEPDSAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIC9</accession>
    <name>F7KIC9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HMPREF0994_05608</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05608"/>
    <dbReference type="EnsemblBacteria" id="EGN32319">
        <property type="protein sequence ID" value="EGN32319"/>
        <property type="gene ID" value="HMPREF0994_05608"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6126"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_9_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="564"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="809"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN32319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="936" mass="104685" checksum="37123005139E65EA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIF8</accession>
    <name>F7KIF8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05637"/>
    <dbReference type="EnsemblBacteria" id="EGN32348">
        <property type="protein sequence ID" value="EGN32348"/>
        <property type="gene ID" value="HMPREF0994_05637"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6161"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="438"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN32348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="540" mass="63313" checksum="C1A6D5912D6BAAB6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIJ7</accession>
    <name>F7KIJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1016_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05676"/>
    <dbReference type="EnsemblBacteria" id="EGN32165">
        <property type="protein sequence ID" value="EGN32165"/>
        <property type="gene ID" value="HMPREF0994_05676"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6202"/>
    <dbReference type="eggNOG" id="COG4804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2569452_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="96" mass="11137" checksum="34157F38AD826BDA" modified="2011-09-21" version="1">MIKNEISAAGNLIQIIIQSRQNALKKVNEELIQMYWKVGEYLSTESTKVSFGDAYIDTVAEEVQNAFPGIKGFNRRGLYRMKKFYETYADDVFYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIS1</accession>
    <name>F7KIS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_05760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006876012.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05760"/>
    <dbReference type="EnsemblBacteria" id="EGN32249">
        <property type="protein sequence ID" value="EGN32249"/>
        <property type="gene ID" value="HMPREF0994_05760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6298"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN32249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="35780" checksum="3DD97EA636615271" modified="2011-09-21" version="1">MNGLKTDTIINRDALYALRELPEESVHCCVTSPPYYALRDYGLDMQIGREDTPEQYIDRLTEVFRELRRVLRSDGTLWLNIADTYCGTGNKGYHADPKNPKGRNGQQIAKNNRVSGCKQKDLIGIPWLLAFALRADGWYLRSDIIWQKENPMPESVKDRPTRCYEHIFLLTKSKKYFYDAAAIAEPLAPTTAARYRTGRSAGQKYADEVPGQGKVQGLNRARSGSYYDEALMPTMRNRRDVWLINTVPYKGGHFAAFPPKLAETCIKAGCPKGGVVLDPFFGSGTTGAAARQLDRHYIGIEINAEYCALARARIGGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIV4</accession>
    <name>F7KIV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05783"/>
    <dbReference type="EnsemblBacteria" id="EGN31859">
        <property type="protein sequence ID" value="EGN31859"/>
        <property type="gene ID" value="HMPREF0994_05783"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6324"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098247_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="193" mass="21869" checksum="65AE5740426EA6F1" modified="2011-09-21" version="1">MKKQAYNPYLPSWEYIPDGEPYVFNDRVYIYGSHDRFRGHAYCLNDYVCWSAPADDLGDWRYEGVIYRKTQDPLNPDGYMCLYAPDVTVGPDGRYYLYYVLDKVPVVSVAVCDTPAGEYEFYGYVHYADGTRLGEKEGDEPQFDPGVMTEGENTYLYTGFCAIGDKSRSGPMGTVLGPDMLTIKEGPVKADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIX0</accession>
    <name>F7KIX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05799"/>
    <dbReference type="EnsemblBacteria" id="EGN31875">
        <property type="protein sequence ID" value="EGN31875"/>
        <property type="gene ID" value="HMPREF0994_05799"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9D2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036591_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="535" mass="59631" checksum="8B739657C11633B7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ02</accession>
    <name>F7KJ02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255607.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05831"/>
    <dbReference type="EnsemblBacteria" id="EGN31459">
        <property type="protein sequence ID" value="EGN31459"/>
        <property type="gene ID" value="HMPREF0994_05831"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6380"/>
    <dbReference type="eggNOG" id="COG4030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039495_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="366" mass="42133" checksum="4702CF53AF42A80A" modified="2011-09-21" version="1">MFMGSLDSLPLLRKGRSRTINWENRTGEKGKGGMAASDLGPSRKGSPCIPCLEPGETVTLAEMDGPGVIQHIWITVTDRTSDRNRYILRDLVLRMYWDGEETPSVESPLGDFFCCGFGVSYPVNSLPIAVNPTRGFNSYFSMPFGKKAKISIENQCDEAVNAFFYQVDYCLLDELPAETGYFHAVWRRQRLTEKAKDYVILDGVKGRGQYVGTYMALTTLERYWYGEGEVKFYIDGDEEYPTICGTGTEDYFGGAWSFATQKNGRTVENTFCTPFLGYPYYSHHDTFLHNDYHNDDQMPQRSFYRWHIQDPVIFEEDLKVTVQQIGVYHGGLFERQDDVATVAYWYQTEPHQPFGELMERKERWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ35</accession>
    <name>F7KJ35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_05864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05864"/>
    <dbReference type="EnsemblBacteria" id="EGN31492">
        <property type="protein sequence ID" value="EGN31492"/>
        <property type="gene ID" value="HMPREF0994_05864"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6417"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="153"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN31492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="321" mass="36043" checksum="0266252C58F87DEE" modified="2011-09-21" version="1">MKKDGGWQKLKGEITDEIYKFTWKDVLITLGILLTATIVALVYYRISASNINVIMFYTLALLFISRLTSGYLPGIAAAMISVVCVNFLFTYPYGQINFILEGYPVTFICMLVVSVLTSASASHMKRQSRILADREKKLAEAEKEKMRANLLRAVSHDLRTPLTGIIGASSSYLENEARLNTDEKRTMVRHIREDANWLLNMVENLLTVTRIRDDSASVNKSLEPVEEVMAEAVYRLKKRIPDAQIKVLLPEEFVMIPMDATLIEQVLINLMENAIFHAGSTEPVECRAEIGRDEVTFLVTDQGVGIPEEKLATIFDGTGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJX5</accession>
    <name>F7KJX5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_06164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255940.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06164"/>
    <dbReference type="EnsemblBacteria" id="EGN30657">
        <property type="protein sequence ID" value="EGN30657"/>
        <property type="gene ID" value="HMPREF0994_06164"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6752"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN30657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="26356" checksum="476A19E3F81D39F3" modified="2011-09-21" version="1">METKHNLLIVEDEKAISNLIATTLETQGYHYEKASNGAQAMLAVTSHSPEVILLDLGLPDMDGLDIIRKVRSWSSVPIIVISARTEDQDKIEALDAGADDYLTKPFSVEELLARLRSTFRRISYMQSEQGEVSTVFINGDLKIDFAAAAAYMGEQELHLSPIEYKLLCELARNVGKVLTHQYLIKKVWENVNVSDIPSLRVYMATLRKKIEPDRENPQYIQTRVGIGYKMNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK75</accession>
    <name>F7KK75_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">HMPREF0994_06254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256030.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06254"/>
    <dbReference type="EnsemblBacteria" id="EGN30523">
        <property type="protein sequence ID" value="EGN30523"/>
        <property type="gene ID" value="HMPREF0994_06254"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6852"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_9"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN30523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="398" mass="43097" checksum="12B4981DA743EFF6" modified="2011-09-21" version="1">MKVLVINCGSSSLKYQLIDSDSEEVLAKGLCERIGIDGSNIAHQPAGGDKVKQEADMPDHTAAVKLVIEKLTDEKVGVIRSLKEIDAVGHRMVHGGENFSGSVCINEEVLQAIEDCNDLAPLHNPANLIGVRSCQAIMPDVPMVAVFDTAFHQTMPEKAYLYGLPYEYYKKYKIRRYGFHGTSHDFVSERAARILGRDRKDLKIIVCHLGNGASVSAVKYGESVDTSMGLTPLEGLIMGTRSGDMDPAIVSFLAEKEGLSASEVIDICNKKSGVLGLSDGYSSDFRDLVQASESGNDQAKYALEAYAYRVGKYIGAYAAAMNGVDVIVFTAGVGENNSEVRAMIAQYIGYLGTNIDLEKNKVRGEEIILSDEGSAVVTMVVPTNEELAIARETVRLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK85</accession>
    <name>F7KK85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_06264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256040.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06264"/>
    <dbReference type="EnsemblBacteria" id="EGN30183">
        <property type="protein sequence ID" value="EGN30183"/>
        <property type="gene ID" value="HMPREF0994_06264"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6867"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005571_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="476"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="737"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="497"/>
            <end position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN30183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119511" checksum="E0DC885C2268F65D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB1</accession>
    <name>F7KKB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06290"/>
    <dbReference type="EnsemblBacteria" id="EGN30209">
        <property type="protein sequence ID" value="EGN30209"/>
        <property type="gene ID" value="HMPREF0994_06290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6894"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113705_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01046">
        <property type="entry name" value="Rubrerythrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045236">
        <property type="entry name" value="Rubrerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="50"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN30209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="180" mass="19800" checksum="C58902001CEEBF98" modified="2011-09-21" version="1">MKFVCQVCGYVYEGEKAPEKCPVCGAPAEKFTAQSGKMEWAAEHVVGVAQGASEDIMEDLRANFAGECSEVGMYLAMARVAHREGYPEIGLYWEKAAYEEAEHASKFAELLGEVVTDSTKKNLEMRVEAENGATAGKFDLAKRAKAANLDAIHDTVHEMARDEARHGKAFQGLLERYFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKG4</accession>
    <name>F7KKG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256105.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06343"/>
    <dbReference type="EnsemblBacteria" id="EGN47951">
        <property type="protein sequence ID" value="EGN47951"/>
        <property type="gene ID" value="HMPREF0994_06343"/>
    </dbReference>
    <dbReference type="GeneID" id="29727500"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6947"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033229_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363856" evidence="2">
        <location>
            <begin position="30"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="623" mass="68358" checksum="07C5D310DFE7A1CB" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKK4</accession>
    <name>F7KKK4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06383"/>
    <dbReference type="EnsemblBacteria" id="EGN47991">
        <property type="protein sequence ID" value="EGN47991"/>
        <property type="gene ID" value="HMPREF0994_06383"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339NG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029690_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN47991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="270" mass="29340" checksum="5B323552F2E20EFC" modified="2011-09-21" version="1">MSDRDWFGTTEETQQNKEAEGMAEDLSAADKDGEQKAEAEAAGAEAPQNTSDIRQGDSTPNQEYQDAVLPEGNQNQGNANSNTAQGYPAGNSQYRNTAAYGQGNSSPGGQAPYNGPYYQGNTYGNTDTCQNPNMYQNPNTYQNPNTYQNSNTYQNPGRNRNPFPNGNSYQQMNGQPGYQGYYPESPYQGNPIQPAGPEEPMKISDWIVTLLVLSIPCVGLVMLFVWGFGGTENQSRANFCKAALIWSAILLVLAFIFYMVVLAGVISGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKZ8</accession>
    <name>F7KKZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256289.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06527"/>
    <dbReference type="EnsemblBacteria" id="EGN47246">
        <property type="protein sequence ID" value="EGN47246"/>
        <property type="gene ID" value="HMPREF0994_06527"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7149"/>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087257_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="62"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN47246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="159" mass="16926" checksum="B22D87B8AFC485E9" modified="2011-09-21" version="1">MDTLMILGIILFIAGFILIAIEMVIPGFGAPGISGIACLIAGVFLTADSVAEGAFITVIVLALLGIMMAVIVWLLSKGKIHSPIILEEEQKKDEGYISSTDLDYLLGKKGIAETDLRPTGVGNFEGVNFDVISEGKYISKGTNLEIIKVNGSKLIVKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL29</accession>
    <name>F7KL29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_06558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256320.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06558"/>
    <dbReference type="EnsemblBacteria" id="EGN47277">
        <property type="protein sequence ID" value="EGN47277"/>
        <property type="gene ID" value="HMPREF0994_06558"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7180"/>
    <dbReference type="eggNOG" id="COG2212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN47277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="113" mass="12705" checksum="40105E40E3A3C6B6" modified="2011-09-21" version="1">MNGLENAYEAVFTAALIFLGFMLLLCLIRAVRGPRVADRLVAVNMMGTMVMVMIAILALLLQEGYLVDICIIYAMISFLAVIVLTKVYMGVYQETRKKDRKKDTPEEENAHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLF1</accession>
    <name>F7KLF1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46605.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359698.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06681"/>
    <dbReference type="EnsemblBacteria" id="EGN46605">
        <property type="protein sequence ID" value="EGN46605"/>
        <property type="gene ID" value="HMPREF0994_06681"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46605.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="272" mass="30603" checksum="383CBC80BB5903A3" modified="2013-09-18" version="2">MHKIIKNIPRLIAITLVSLISFIPFYYTVVMATHSTDEVMLGLSLLPGKYLFQNIATALNKTFWISFRNSLLVSLLSMTASVSISLMAGYGLAAYEFRVKKIIYNFVLLTMMVPSVLGIIGYMQEMRVLHLSGTLAPLILIWFPNGFGVFWITQYLKNSLQMELVESARIDGCNEFKIFYRIVLPCIKPAIISLCLLIFLWSWNSYLLPLVMINKADNYTIPLYIQSLGNEHRKDIAAQITGLLISVVPLIAAFAVFSKDFIRGLTEGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLP8</accession>
    <name>F7KLP8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256530.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06777"/>
    <dbReference type="EnsemblBacteria" id="EGN46369">
        <property type="protein sequence ID" value="EGN46369"/>
        <property type="gene ID" value="HMPREF0994_06777"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7405"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005043_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5110" evidence="3">
        <location>
            <begin position="614"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="795" mass="91721" checksum="485703700B4792B2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLP9</accession>
    <name>F7KLP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256531.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06778"/>
    <dbReference type="EnsemblBacteria" id="EGN46370">
        <property type="protein sequence ID" value="EGN46370"/>
        <property type="gene ID" value="HMPREF0994_06778"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7406"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="10"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN46370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="35474" checksum="B60E8765EB3F5A04" modified="2011-09-21" version="1">MNIVVLDRSSVGEDVSVEPLRKYGNVTFHMTTRDEEAAERVKDADIIVVNKTPMNACTLEGASHLKLVCEFATGYDNVDLEYCRKRGIPVVNVVNYSTAAVAQHTIACVLYILEKLRYYDDYVKTGVYASQPRFSHFGLPYYELDGKTWGIVGMGNIGRKTAAIAAAFGCRVIYFSTSGKSSCGEYTRVDFDTLLKESDVITLHCPLNDRTRNLIDRDALEKMKKTAVLVNVARGAVVNEADLCRALQEDQIMGAGIDVLSQEPINPDNPLLQIRDSSRLLITPHMAWASVEARTRVVTETCKNIEAFLRGEPRNVLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRV4</accession>
    <name>S2KRV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_07170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EPC05174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360083.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07170"/>
    <dbReference type="EnsemblBacteria" id="EPC05174">
        <property type="protein sequence ID" value="EPC05174"/>
        <property type="gene ID" value="HMPREF0994_07170"/>
    </dbReference>
    <dbReference type="GeneID" id="29727817"/>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028597_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="551" mass="62673" checksum="04BFADAC61105665" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRZ0</accession>
    <name>S2KRZ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EPC05204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360053.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07151"/>
    <dbReference type="EnsemblBacteria" id="EPC05204">
        <property type="protein sequence ID" value="EPC05204"/>
        <property type="gene ID" value="HMPREF0994_07151"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZJ9G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092314_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="266" mass="31118" checksum="020EBCD111C220DA" modified="2013-09-18" version="1">MVTNQVIILCNGKGKTDVTDKERFDWARDKIVGTVRERQGIGTLSEKTVHAVLKNYYAPDEDMHEIPIEGSVADIYTGTEIVEIQTRSFDRMRDKLRKFLPLYPVTIIYPIPYEKWLIWIDEETGEFSSRRKSPVKGNAYAAFRELYKIKNFLLEENLHFKFVFLNMEEYRLLNGWSRDKKKGSSRFDRIPLEMVDVMEIDCPRDYLQLVPYGIPEPFTVKEFAKEVHIRANLAQTVLNILTYTEVVERVGKKGNAYLYQVLEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS06</accession>
    <name>S2KS06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EPC05224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05224">
        <property type="protein sequence ID" value="EPC05224"/>
        <property type="gene ID" value="HMPREF0994_07135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144816_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003203">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="109" mass="11997" checksum="04623B9750A0906C" modified="2013-09-18" version="1">MTSLQILITLLVIALVTILTRALPFLFFPAGKKTPEIINYLGTVLPFAAMSMLVVYCFKSVSILKGSHGIPELLAAAFVLCVHKWKHNMLLSIGGGTVLYMFLVQVIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS60</accession>
    <name>S2KS60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359995.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07118"/>
    <dbReference type="EnsemblBacteria" id="EPC05269">
        <property type="protein sequence ID" value="EPC05269"/>
        <property type="gene ID" value="HMPREF0994_07118"/>
    </dbReference>
    <dbReference type="GeneID" id="29725835"/>
    <dbReference type="eggNOG" id="COG4935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503305_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="525" mass="60879" checksum="A9B83F466956AB30" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS89</accession>
    <name>S2KS89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,3-propanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359757.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06987"/>
    <dbReference type="EnsemblBacteria" id="EPC05319">
        <property type="protein sequence ID" value="EPC05319"/>
        <property type="gene ID" value="HMPREF0994_06987"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="386" mass="40991" checksum="7AAEB4592B9F097F" modified="2013-09-18" version="1">MAREFIVPGRIISGAGALDAAGAALKEMGKKALVVTDKVMVQLGNCARLEAALAGQGIGCVVYDEITGEPTDIMIENGLRVYQENGCDFLVALGGGSPIDSMKAIASLVKNGGSISDYMGKIIDVPVPPMAAIPTTAGTGSEATQFTIITDTKKDIKMLLKGAVLMPKLAVIDPQFTMTAPPKITAATGLDALCHAIEAYTSRKAQTLSDTFALSAVKRIFEFLPAVYHDGKNEEARIQMSVAALEAGIAFNNSSVTIIHGMSRPIGALFHVAHGLSNAMLMKECLSFALEGAVSRFAELGRAVGAAKESDPDAEAGSRFLAAVQEMITGLEIPTLQEYGIDRETFYSQIEKMAQDAMDSGSPQNTMRQPDRQAVMDIYKKIYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAI3</accession>
    <name>S2LAI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EPC05236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359924.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07085"/>
    <dbReference type="EnsemblBacteria" id="EPC05236">
        <property type="protein sequence ID" value="EPC05236"/>
        <property type="gene ID" value="HMPREF0994_07085"/>
    </dbReference>
    <dbReference type="GeneID" id="29725055"/>
    <dbReference type="eggNOG" id="COG2173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333655_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="854" mass="98675" checksum="9DDF5E02CA3B3B42" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAQ1</accession>
    <name>S2LAQ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_07079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EPC05271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05271">
        <property type="protein sequence ID" value="EPC05271"/>
        <property type="gene ID" value="HMPREF0994_07079"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EPC05271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="138" mass="15466" checksum="5AE6C9DC4E18C021" modified="2013-09-18" version="1">MNEKPGMDNVSVSSDKKKMGKRIKAARNRAGLSQEALGAAVGKSSVYMSNVETGKANASLETVVSIANALRVSVDEFLYDEVERTEPALPREFMEELKDCEPYEIRAISEYLKETKKILRECREQKQNQEPVIPIEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>S2LJK9</accession>
    <name>S2LJK9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360148.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07203"/>
    <dbReference type="EnsemblBacteria" id="EPC05148">
        <property type="protein sequence ID" value="EPC05148"/>
        <property type="gene ID" value="HMPREF0994_07203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="200"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="447" mass="48824" checksum="46EA3684EF1BB874" modified="2013-09-18" version="1">MFENIGENLSAMISIPTVSGAGNEPFYHIEEYRDYLRTTFQTLFTAADIIPVGEALLLKLRGTGSHLLHEEKTPGPLLPVLFTGHMDVVPAADEASWKFPPFSGRIADGCVWGRGSQDMKGPQCALLSAFESLLEEGWRPKRDIWLYLSCDEETGGFTTGRAAKLLKDKKIHFETVFDEGGTICDDFMGLVKGKAALFGIAEKGSLEYRFTALSRGGHSANPPAHSAIVRLADFIHEVEYADFFRKELSEGNRAMLRAAAGYSPDTIRDKLLQAADEQEDYPVLHEICKDADTLLGTTIAFTMIEGGTAFNVMPKKAVLTANVRVSCTEKAEEITEKLKIAAKRHNLLCELAGGRDAAPESSTGAPGYLSMKESVEETYPGLPVIPFVLGGGTDSRHFLELTDNVLRFSPMYALPEQGSGVHGDNEYASIQAVKDAAQCYSVLLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2G0</accession>
    <name>F7K2G0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249988.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00039"/>
    <dbReference type="EnsemblBacteria" id="EGN48272">
        <property type="protein sequence ID" value="EGN48272"/>
        <property type="gene ID" value="HMPREF0994_00039"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.42"/>
    <dbReference type="eggNOG" id="ENOG5032IND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150560_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043753">
        <property type="entry name" value="DUF5699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18956">
        <property type="entry name" value="DUF5699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="96" mass="10205" checksum="522336D3AF6973A3" modified="2011-09-21" version="1">MRLIFKLLAFPFVLVTGLLYLVCKFLVIASGAVLGILSGIVFLASLVLFFTAGVWAGLAWLVIAFLISPYGLPMAAAWLVGMIGGANHALKDFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2G5</accession>
    <name>F7K2G5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249993.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00044"/>
    <dbReference type="EnsemblBacteria" id="EGN48277">
        <property type="protein sequence ID" value="EGN48277"/>
        <property type="gene ID" value="HMPREF0994_00044"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.47"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="321" mass="36109" checksum="AFB80BEEB9AEF0C7" modified="2011-09-21" version="1">MTNQYMTKLYHDLLSNSPQTVTIDIPADMGTGQISQVVTKQGAVVSDWKMNYFSDMNVQGVSCEDYIQLLFCFNDGVSWNIADARQCVSIQKGESCIYRGHGKMEYLCYSGKTNFLFKNIKIPMPYFHKILSDYFEDSEIDAYEKKLLTGISKVSITPYMEHIFAELKDFTQYRGGLGYLFLESKVFELLSVYLSEVLELSILSSSYISISKSDRDSITEAKRIIDSQLAFAPSCEKLAKKVNISVSKLTKGFNSLFGTSVHAYIIDQRLEKAAGLLLESDLNVSQIATLVGYSKPSNFAAAFKKKYGVIPKNYKDENTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2M1</accession>
    <name>F7K2M1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00100"/>
    <dbReference type="EnsemblBacteria" id="EGN42717">
        <property type="protein sequence ID" value="EGN42717"/>
        <property type="gene ID" value="HMPREF0994_00100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.106"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN42717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="307" mass="34361" checksum="823089B830ADA8E0" modified="2011-09-21" version="1">MNTFIVFQQMLILLAMMIIGYVSFRKDWLDRNAYTKLSKIVVNILNPLIIINGVMERDSGESTEKIVLNLMFIVLYFVILILASFLVVRLLKVEARHSHLYRMMMVFSNVGFMAIPLISSIYGKESVFYVSFYILGFNLLLYTYGIHLISRGSGEKKEKLQLKKLMNPGVAACLLSIVIFIWRIPVADSVKSFVGYMGNAAIPMSMMLIGASIAQTDIKELLRDVKIYGLLAIKLLALPIAAALILRNLELPRELAGIFIFMLGMPVASIVVPLAAEYEADEICCTRGTVLSTLLSIITIPIVSLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2P1</accession>
    <name>F7K2P1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42737.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359804.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00120"/>
    <dbReference type="EnsemblBacteria" id="EGN42737">
        <property type="protein sequence ID" value="EGN42737"/>
        <property type="gene ID" value="HMPREF0994_00120"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42737.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="193" mass="21647" checksum="167EBC6BE6353011" modified="2013-09-18" version="2">MKILLLCLKAFETMEFSPFIDIMGWAHDDFNCDIHVDICGFNPKILSTFGVTITADILIDDVDVNNYDALAIPGGFEEYGFYTEAYHDKTLNLIRSFYSQHKPIASVCVAAFPLAKSGILNKKKATTYHLRGGYKRKELEKFGVILGDEWLAMDDNIITSSCPRTAPDVAFRLLELLTSTEKAAEVKKAMGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Q1</accession>
    <name>F7K2Q1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00130"/>
    <dbReference type="EnsemblBacteria" id="EGN42747">
        <property type="protein sequence ID" value="EGN42747"/>
        <property type="gene ID" value="HMPREF0994_00130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.137"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357043" evidence="2">
        <location>
            <begin position="33"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="442" mass="47541" checksum="7315BFEE7954E21C" modified="2011-09-21" version="1">MRKKWALVLCAALTAMSLAGCGGKTGETNAPAAESSAGKTESTPEGTQEAQAPSGDVMTIEFFQQKGEEGPQKGYQAIIDKFNAANPDIKIEMNTVPDAGTVLTSRISSGDIPVIFSDYPTQQQFRQKVANGYVQDLSGQDFLKNVNESSLEMTKQEDGGYYALPYSRNYMGVFYNMDIFEENNLEIPETWDDFVKLCDTVKAAGITPVGLFGKDPGRVGHTFQCTTVAWAPNGVETIGKAAQGEAKLEGDPEFVSAFDKMSVLLSYANEDALALSDTACWEKFVNGEYAMCVTGSYARGTLQASNPDIRLGVFPLPNDTKETTHVLSGIDAAVCVSAKASDEEKAAAYKFLAFLADPENAQLFCNSDGAPSCINGVENDDEGISPMTDMINAGQTHDWMASTINNNVITDLYNVVQGFWADKDVDAVLKNMDASIAVTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K340</accession>
    <name>F7K340_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN37908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250218.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00269"/>
    <dbReference type="EnsemblBacteria" id="EGN37908">
        <property type="protein sequence ID" value="EGN37908"/>
        <property type="gene ID" value="HMPREF0994_00269"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.292"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044464_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN37908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="33659" checksum="756D28FD8D950281" modified="2011-09-21" version="1">MNFTGRTWRPPYEAGSFIIQAASGCTYNKCRFCSLYKGECYRMSPLSEWEEDLQELSLYYPNARRIFWTGANPFAMSYEHLKTRALSVYDYLKECQTMAMFASIRDIKPKKVKQLRTLRSLGINGLSIGTESGDDYTLRLADKGYTARDIIDQCRKLDEAGIEYYFVYMTGLAGKGNGYQNAVNSAKVFSKVNPRFISVDSLTLFEDTELFEMAERGEFVPAGEKERIEELQVFIQNLRLKVHLFADSISNFYPVTAYLPRDKDLVIGELQNIMDTVSEEEMLAYRRNLKALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K399</accession>
    <name>F7K399_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33473.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359826.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00332"/>
    <dbReference type="EnsemblBacteria" id="EGN33473">
        <property type="protein sequence ID" value="EGN33473"/>
        <property type="gene ID" value="HMPREF0994_00332"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_5_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33473.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="271" mass="29753" checksum="E1127D071A218042" modified="2013-09-18" version="2">MNQRKKTILIFALALLFLTSVTLSGIFCYGGARKTDFSVKNLAPCLRYPFGTDWMGRNMLARTLTGLSISIRIGLCTAGISALLALTLGIMSAVLGKKVDAVISFLIDTIMGIPHILLLLLISYAFGKGFKGVVLGVALTHWPSLARVIRGEVMQLKESEYIRIAAKLGQNRLQIAWRHMVPHLFPQFVVGLILMFPHAILHEASITFLGFGLSSEQPAIGIILSESMRYLITGKWWLAMLPGLMLVLTVVLFDVAGNSLRRILDPSSAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3A7</accession>
    <name>F7K3A7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33481.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359828.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00340"/>
    <dbReference type="EnsemblBacteria" id="EGN33481">
        <property type="protein sequence ID" value="EGN33481"/>
        <property type="gene ID" value="HMPREF0994_00340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741569_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="259"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33481.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="415" mass="47669" checksum="B813FB22EAC2281D" modified="2013-09-18" version="2">MDSREHKKKFNRVDVQVFIMTIVIVVISCSLIFLINYGLSYNNMIMDLKHRSTNLHDYLEKYLDADMFSELNVKEDDGLILYQNSRLRLEGARNAAGVRYLYTAKVTDKGQFIYLVDGLPTDSPDFRYVGDPIEAECIPDMKRALSGETVFPNEINKTTWGPVFISYFPMHDGDKVIGVLGIEFDATSQYNTYRLMKITTPIVLLLSCIAAAVVAVLMFRRISNPLYKDLSNTDMLTGLKNRNAFEVDLHNWDQYEGKKELAILSFDLDRLKDVNDIYGHAKGDEYLILGSSIIGEALYGKYVLYRIGGDEFVAVIQNGKPEEVDGMFREIGVMAEQESRNQGYEVSISSGYAFYDPEQDKKLADTLRRSDAWMYRNKRKREYGIWEKEDRKKEDLIGEGNENDNREGERSEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3B6</accession>
    <name>F7K3B6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250298.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00349"/>
    <dbReference type="EnsemblBacteria" id="EGN33490">
        <property type="protein sequence ID" value="EGN33490"/>
        <property type="gene ID" value="HMPREF0994_00349"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.377"/>
    <dbReference type="eggNOG" id="ENOG502Z7N2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071251_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="26540" checksum="0CFBAB1B5B9A8259" modified="2011-09-21" version="1">MREINHFNDFIKELWSVGFTIGGENGEGVFTLSDAFGESIAWHTEDPETDPWEWRIRVLDEYTDIAYGKLFFRKSGYITKEWYPYFLAVRRGKKELQEEYEEGNVTLMAKRIYDVLSEEKELPVHLLKQYGGFSGEDKSGFDKALTQLQMDFYISICGRARKRSRSGEEYGWSSTVFCLTENLFEEEVFRKAGKLSYEQAFKRIEKQIYLQNPQARNTKVNKFITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3I4</accession>
    <name>F7K3I4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00413"/>
    <dbReference type="EnsemblBacteria" id="EGN31928">
        <property type="protein sequence ID" value="EGN31928"/>
        <property type="gene ID" value="HMPREF0994_00413"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.453"/>
    <dbReference type="eggNOG" id="COG3877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132137_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018658">
        <property type="entry name" value="DUF2089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09862">
        <property type="entry name" value="DUF2089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="171" mass="19834" checksum="60CED5C5CB14CD15" modified="2011-09-21" version="1">MNILIEILLCYINIFNIYINYFNLNVDIIDLEVYIIDIKRKEGDRMYQVISSCPVCGKKLKVVKLQCENCDTVIENDFCLSKFDYLSTEDLFFAETFLKCRGNIKEVEKELKISYPTVRSRLDDIIQKLDGNPNVRSNVQSASSSRKKEILNALENGEITPEEALEQMKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3J9</accession>
    <name>F7K3J9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">HMPREF0994_00428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250377.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00428"/>
    <dbReference type="EnsemblBacteria" id="EGN31943">
        <property type="protein sequence ID" value="EGN31943"/>
        <property type="gene ID" value="HMPREF0994_00428"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.468"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="114" mass="12964" checksum="16F9A82CE0BE9D8A" modified="2011-09-21" version="1">MHELGIIVHISRTLEEVAKENQLTEIGSVTLEIGEVSGVVPEYMTDCWKYYRRKSELLEESELKIEIRPAVTFCEACRKTYPTVRYGRQCPGCGSWETSLLTGNECSIKEIEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3L0</accession>
    <name>F7K3L0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250388.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00439"/>
    <dbReference type="EnsemblBacteria" id="EGN31954">
        <property type="protein sequence ID" value="EGN31954"/>
        <property type="gene ID" value="HMPREF0994_00439"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022176_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="394"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="527" mass="61359" checksum="50107B1D356874E6" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K410</accession>
    <name>F7K410_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250546.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00597"/>
    <dbReference type="EnsemblBacteria" id="EGN44785">
        <property type="protein sequence ID" value="EGN44785"/>
        <property type="gene ID" value="HMPREF0994_00597"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="25975" checksum="3D1BADA598144D37" modified="2011-09-21" version="1">MNMSFYTAALGAAGQQEKMNVIANNIANVNTDGFRSKNAVFSDLMYYNMRDEQGADTRVKAGSGIAMGRTDTDFSESSMAPTGGNTDFAISGRGFFMLQDPNTQAVSYSRNGKFNMSLRADGFYLVNDNGKLVLDENRNPIRLDEEGIVGGARPGIYTFPVQQGMLNTGNNELTATEKNGEPVLSADAELRQGYLEQSNVNLADEMSKTIECSRAYSYVLKMIQTSDEIEQVINSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K496</accession>
    <name>F7K496_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250543.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00594"/>
    <dbReference type="EnsemblBacteria" id="EGN44782">
        <property type="protein sequence ID" value="EGN44782"/>
        <property type="gene ID" value="HMPREF0994_00594"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.646"/>
    <dbReference type="eggNOG" id="COG3434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044951_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HDOD" evidence="2">
        <location>
            <begin position="199"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN44782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="424" mass="48282" checksum="4248A0D239E68FB0" modified="2011-09-21" version="1">MDKCVVRQAIKEVSTQNIIGYEILFQTNGDDLYSKTENSAADKMINFLMQNSGKIFSDKPTFMTFTPSLLFRNLPKMFGKETLVIQIEDNLIVHPLALPMIKKYKAEGYLFAINDFQFSPKYFGMLEYTDYIRISVSGKDEKERTSLDNVVKMAQAFGKKCIATGVNGKEEYELAAALNVEYMEGNYIAETLMTKANKIDYLQGNFFQLVGAISKDEPDMDELEEIISRDAGLTYALLKMVNSAYFALRKRTASVRQAIVTMGLGQLREWVYMLSIDEEDPTGSSAEILKMSFLRAKFAQELTGLIHKPDFPINKFEAYMMGMFSNLEYMVDATMEEILEEIPVKDEVKKALISYEGDAGKLMLLILAYEKADWKESKKLAGELGIDATTLAQIYMDCIQNVNEIWQALTTDFKRKEDSVEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4E8</accession>
    <name>F7K4E8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250677.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00728"/>
    <dbReference type="EnsemblBacteria" id="EGN44077">
        <property type="protein sequence ID" value="EGN44077"/>
        <property type="gene ID" value="HMPREF0994_00728"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.791"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011139_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356402" evidence="2">
        <location>
            <begin position="30"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="4">
        <location>
            <begin position="39"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="311"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="682" mass="75090" checksum="1A6FCE03C4BE6B39" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4H7</accession>
    <name>F7K4H7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">HMPREF0994_00751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00751"/>
    <dbReference type="EnsemblBacteria" id="EGN44100">
        <property type="protein sequence ID" value="EGN44100"/>
        <property type="gene ID" value="HMPREF0994_00751"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.817"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN44100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="152" mass="17203" checksum="501F4563132EDED9" modified="2011-09-21" version="1">MIGEDGSQLGVMSSKDAMKIAEEAGLDLVKIAPTAKPPVCRIVDYGKYRYELARKEKEAKKKQRTIEIKEIRMSPNIDTNDMNTKVIAAKKFITKGNKVKVTLRFRGREMAHMSKSKHILDDFAQMLADVAVVEKAPKVEGRTMTMFLTEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4N5</accession>
    <name>F7K4N5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250772.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00823"/>
    <dbReference type="EnsemblBacteria" id="EGN43532">
        <property type="protein sequence ID" value="EGN43532"/>
        <property type="gene ID" value="HMPREF0994_00823"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.897"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="32715" checksum="BE54D8AB602404A4" modified="2011-09-21" version="1">MKTREDKIFNAVGHAVMIILSAAAVIPIILMVISSLTSNGALLRDGYSFFPKEWSAYAYKWVFASNGGMVLKAYGISFLITAAGTACSLLLTIGLAYGLAKKSLPGRNIFTFLVVFTMLFNGGLVPTYINYTNVFHIKDTIFALLVPSLLMNAFNVLLMKSYFVSSVPDEILEAAYIDGASEFQTMRKIAVPLSKPIIATIGMFAGIAYWNDWNNGYIYLVKRTDLYSIQNLLNRLMQNINALTQNASQVGNVNQGLSEIPSVSVRMAMATLGILPIVVIYPFIQKNFVKGITLGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4N7</accession>
    <name>F7K4N7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250774.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00825"/>
    <dbReference type="EnsemblBacteria" id="EGN43534">
        <property type="protein sequence ID" value="EGN43534"/>
        <property type="gene ID" value="HMPREF0994_00825"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="571" mass="65175" checksum="0594F0D7D0495D65" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4P3</accession>
    <name>F7K4P3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00802"/>
    <dbReference type="EnsemblBacteria" id="EGN43511">
        <property type="protein sequence ID" value="EGN43511"/>
        <property type="gene ID" value="HMPREF0994_00802"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50339WE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479597_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="545" mass="57284" checksum="5DC0D8C68B9E10F9" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Q0</accession>
    <name>F7K4Q0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00829"/>
    <dbReference type="EnsemblBacteria" id="EGN43381">
        <property type="protein sequence ID" value="EGN43381"/>
        <property type="gene ID" value="HMPREF0994_00829"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="58"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="292" mass="32548" checksum="2F227BBB51252C1E" modified="2011-09-21" version="1">MMRYKIDIPVKEQPVTLISGITFAQVPYWFPFYNYKDLKMDILAPSGSPGQGKRPLFVWICGGGFATMERSAYIPWLTYFAKRGYIVASVEYRLSNSAHFPAQIEDVKKAIRFLRAHADEYGIDPDRVAVGGESAGGNLASMVGVTNDIAAFDVGEYPEQSSHVSAVVNYYGPAVLVKEPGKRSMDGIPLTDTAGYSRTIQLLGFDPEAEPERAAKTAAQYYINENTVPFFLAHGTGDTLVDISGSDEFYRILSQNHVPVEYYRIQGAAHMGMEFYQDEMSQRVLEFLNKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4T5</accession>
    <name>F7K4T5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PHP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250813.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00864"/>
    <dbReference type="EnsemblBacteria" id="EGN43173">
        <property type="protein sequence ID" value="EGN43173"/>
        <property type="gene ID" value="HMPREF0994_00864"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.942"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082667_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="266" mass="29689" checksum="FD3205E9841FC96C" modified="2011-09-21" version="1">MSKWTVESIKEAYPYLYETHLHTSQSSLCGRAEGREMADACKKAGYTGIFVTDHNWGGNTAAERSLPWETWVSEFAKGYLDAKEEGERIGLDVFFGWEAGFQGTEFLIFGLSPEWLTAHPEIREAGVEEQYRLVKADGGMVIHAHPFREEAYIPEIRLFPEFVDGAEGMNATHTSPLSASHKSGDYDRKARTYAKEHGLVMTAGSDVHSTNIFGGGTAFARKLSDDKDFIQAIQSGEDYVLTDGFSWYSREGELLCTAAREEGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4X9</accession>
    <name>F7K4X9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00908"/>
    <dbReference type="EnsemblBacteria" id="EGN43217">
        <property type="protein sequence ID" value="EGN43217"/>
        <property type="gene ID" value="HMPREF0994_00908"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.993"/>
    <dbReference type="eggNOG" id="ENOG502Z7WG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017816_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="800" mass="91868" checksum="5C9285C7A28E6A81" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K503</accession>
    <name>F7K503_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00939"/>
    <dbReference type="EnsemblBacteria" id="EGN43248">
        <property type="protein sequence ID" value="EGN43248"/>
        <property type="gene ID" value="HMPREF0994_00939"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1026"/>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073005_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356642" evidence="1">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="68"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="210"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="319" mass="35238" checksum="F2F9110640CAA8D2" modified="2011-09-21" version="1">MKDASSKKKALAAVFLLCGVFSLLFSACGKQEKAQSGKAFDIYYLNREETKIVKEVFYIDSQEPESQIRQLISALEATPEDVSLKSPVGNGFRITSFQVEEGGQLDLDVDESYKKLPFTTEILVRAALVRTLSQAEGINHVLMTVGGQPLTDNIGVTVGPMTADAFIDNAGEEMNTYEGVKLKLYFANETGDGLVEVIKPVEYNSNISMEKLVVEYLVKGPDTEDAFPVINPATKILGVTVKDGICYVNLDENFMTQIYNVTADVVIYSIVNSLVELSNVNKVQIAVNGKTDIVFRETFNLVNLYERNLELIKTGENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K576</accession>
    <name>F7K576_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250963.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01014"/>
    <dbReference type="EnsemblBacteria" id="EGN43323">
        <property type="protein sequence ID" value="EGN43323"/>
        <property type="gene ID" value="HMPREF0994_01014"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1107"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026768_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="291"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN43323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="515" mass="60233" checksum="F71D32C26608154C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K593</accession>
    <name>F7K593_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250971.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01022"/>
    <dbReference type="EnsemblBacteria" id="EGN42995">
        <property type="protein sequence ID" value="EGN42995"/>
        <property type="gene ID" value="HMPREF0994_01022"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1118"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046693_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="50"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="440" mass="50142" checksum="8C388605F7F600FE" modified="2011-09-21" version="1">MLLEFRTSNYKSFKEELIFSLIPAPKQKGLDYSVLKQDIDKKSYKGLCSAVIYGSNASGKTNIIGAMDTFKSIVLRGNIRNDDDKNDPNTAACELELIPNNLSENRDPVSFFIKFITDNYLIEYSFSADLGKFLEVDYSRKILSEQLKINDRLIFERNGELKFDSLDTISTLLVNAFEQNADSAIALAQGNLNEEELFLMNGFKNMFSSKLVQIISNWLDNKFMVIYRADSMHLIRKFSEPKKESVYVEKTLNEAAAYFGISSNALGYVVEGDSNEAKLCSIFKGDKKGTAIPAELFESYGTIRFINMFPLVVNALMNGGTLVVDEFDASIHPMALMNIINIFHNDEINRNRAQLIFNTHNPIFLNANLYRRDEIKFVERDEDSHYSSHYSLSDFGTTGKSGVRKNEDYMKNYFVDRYGAIKDIDFTPIFEELISRGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K594</accession>
    <name>F7K594_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250972.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01023"/>
    <dbReference type="EnsemblBacteria" id="EGN42996">
        <property type="protein sequence ID" value="EGN42996"/>
        <property type="gene ID" value="HMPREF0994_01023"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50323K2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109804_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025591">
        <property type="entry name" value="RloB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13707">
        <property type="entry name" value="RloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="218" mass="25978" checksum="09C0402FF6C4A3EC" modified="2011-09-21" version="1">MRKENRTYFFSVEGDTEKWYLDWLQTTINSTPEARFTVKLDSKIQKDPLTRAKGMTILGKTEITHIFDRESEDTIHAKQFQATLDKMKEAQNIGKSITYHLGYSNFTFELWMILHKADCNGTLVNRTQYLTPLNRAYNTNFENLEEYKQENNFKKLLRSFTLEHVRQAVKRSKAIMQKNSEKGYVLQQYKGYRYYRENPSLSVWESIEKILQECHLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5M8</accession>
    <name>F7K5M8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251113.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01164"/>
    <dbReference type="EnsemblBacteria" id="EGN42926">
        <property type="protein sequence ID" value="EGN42926"/>
        <property type="gene ID" value="HMPREF0994_01164"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="15186" checksum="BA7D90B5EA97B0DE" modified="2011-09-21" version="1">MAQTKSYNRLMAGNRLYERRKQLGWSRGYVSEKVGKVEKYYADIERGSCGMSIETLIALSDLYGLSLDYIIYGNPEGKKEEIPDKGKAVMNILKELEPEEYECCLDMMLIYARRAGKSREKNAIGEESKQNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5P0</accession>
    <name>F7K5P0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore photoproduct lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251091.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01142"/>
    <dbReference type="EnsemblBacteria" id="EGN42904">
        <property type="protein sequence ID" value="EGN42904"/>
        <property type="gene ID" value="HMPREF0994_01142"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1252"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057301_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN42904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="330" mass="38079" checksum="9B4E45A246BF1400" modified="2011-09-21" version="1">MVFDAVYYEPDSLKYELGLQLMEQYPDIPWIPIESHNSIKEMQEKPNSEFGHMKRNLIMGIRKTHKYVENHKVSDYLVPFTSSGCTAMCLYCYLVCNYNKCAYLRLFVNREQMLDRLLRRSLKEPGRTYEIGSNSDLVLENTITGNLLYTIPRFAEEGNGSLTFPTKFHMVEPLLSLDHRGKVIFRMSVNPQPLISRIELGTSSLKERIQAVNQMCEAGYPCGLLIAPVILTDGWKNMYRELLEELEAGLSDKMKKTMFLEIILMTYSYVHRAINAEAFPAAPDLYSKELMTGRGRGRYCYRQEARAEAEAFLRSEIRRVLGTVPVLYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5S3</accession>
    <name>F7K5S3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251151.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01202"/>
    <dbReference type="EnsemblBacteria" id="EGN42603">
        <property type="protein sequence ID" value="EGN42603"/>
        <property type="gene ID" value="HMPREF0994_01202"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1315"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_8_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="171"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="326" mass="34285" checksum="D802FE42482FF8BD" modified="2011-09-21" version="1">MNSSSEKTKMTKTGVVFVCALICCFLWGSAFPCIKIGYGLFSIGASDSTSQIVFAGMRFTLAGILVILFGSLLQGKWLRPAKKNLLMVGKLSLVQTVGQYIFFYIGLAHTTGVKSSIIGASNVFLSIVVAVAVFHMEKLSVKKVLGCLVGFAGVVLINVSGGSLDMNLSFLGEGFIFLSAVSYAFSSALIKRYSQEENPVTLSGYQFLCGGILLTGFGLAMGGRVHVGAVSVSGWLLLLYMGFISAAAYTLWGILLKYNPVARVAVFGFMNPVFGVLLSAIFLGESGQAFGLAGVAALLLVCAGIMIVNGPAGDAKVQEPEGVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K603</accession>
    <name>F7K603_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LytR_cpsA_psr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251231.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01282"/>
    <dbReference type="EnsemblBacteria" id="EGN42314">
        <property type="protein sequence ID" value="EGN42314"/>
        <property type="gene ID" value="HMPREF0994_01282"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1401"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="164"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN42314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="430" mass="47393" checksum="3678F61A5EBDD48D" modified="2011-09-21" version="1">MASSKNNGGSRNTGSRNGYSDSRSTGSRSGSRDSRSSGSRNGGRDSRSSDSRYDYRETRSSDSRSGYGDGRNSGPKNKKVTSKKRKARKRRRIILFAVEMVALVVLGVVLWAVMKQTSMQKINVKEEDIVINDTVENNVAMKGYRNIALFGLDARDKNLGKGNRSDTIMIASINLDTGEVKLCSVYRDTYMNLGNDKYSKCNAAYASGGPEQAISMLNMNLDMNITDYVSIGFNGMIDVVNSLGGVEIDIREDEIKNLNDYQASMFSTETKERLTDDYVKVTQPGLQTLNGLQATAYCRIRYTAGDDFKRAERQRTVLLAILEKAKTASVGTLNDTLDKVLPNVATNLDTKEMLSVLKDLASYKVVATDGFPFETNRVTGKVGKAGSCVIPTSLEDNVVLLHKFFFEQEEYTPSKSVSNYSARVSSDTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6E3</accession>
    <name>F7K6E3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6311 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251397.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01448"/>
    <dbReference type="EnsemblBacteria" id="EGN41922">
        <property type="protein sequence ID" value="EGN41922"/>
        <property type="gene ID" value="HMPREF0994_01448"/>
    </dbReference>
    <dbReference type="GeneID" id="29723395"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1578"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023163_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046278">
        <property type="entry name" value="DUF6311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19830">
        <property type="entry name" value="DUF6311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6311" evidence="2">
        <location>
            <begin position="17"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="552" mass="62805" checksum="EAA628D6C89F0C60" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6M9</accession>
    <name>F7K6M9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01539"/>
    <dbReference type="EnsemblBacteria" id="EGN42013">
        <property type="protein sequence ID" value="EGN42013"/>
        <property type="gene ID" value="HMPREF0994_01539"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1679"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111509_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="223" mass="25108" checksum="B2D58B76DC7B8E84" modified="2011-09-21" version="1">MKKEIAVTERPEIFTEQYLAAFGNMSWYDFVTAMPSLVFVVTGWKSNGKENACLHSWSSFAGSGADNFICILGKVNKDGHMYQSLKETKVCVLNFPSNDIYDRCIKMIGNNQFETDEITASGLTAEAALKVNAPRIKECFLNIEYEFLWEHELFEGSREAAVALKAVNICMDSERYDQSRLGRYGRNGFLFQIDQPTNPETGETTPFGPGIVEQGKPVPWITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6P4</accession>
    <name>F7K6P4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_01554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251503.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01554"/>
    <dbReference type="EnsemblBacteria" id="EGN42028">
        <property type="protein sequence ID" value="EGN42028"/>
        <property type="gene ID" value="HMPREF0994_01554"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1697"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_51_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="178"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="468"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="502"/>
            <end position="509"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN42028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="716" mass="78506" checksum="266A73526E7AE39D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6Q7</accession>
    <name>F7K6Q7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251516.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01567"/>
    <dbReference type="EnsemblBacteria" id="EGN42041">
        <property type="protein sequence ID" value="EGN42041"/>
        <property type="gene ID" value="HMPREF0994_01567"/>
    </dbReference>
    <dbReference type="GeneID" id="29724352"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1712"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004617_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="835" mass="93686" checksum="9B06A131094CB878" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6T3</accession>
    <name>F7K6T3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette, subfamily B, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_01600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009004416.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01600"/>
    <dbReference type="EnsemblBacteria" id="EGN42074">
        <property type="protein sequence ID" value="EGN42074"/>
        <property type="gene ID" value="HMPREF0994_01600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1751"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN42074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="591" mass="65619" checksum="4C29398C63A6E8D7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K765</accession>
    <name>F7K765_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease III</fullName>
            <ecNumber evidence="9">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nth</name>
        <name evidence="11" type="ORF">HMPREF0994_01694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="9"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251607.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01694"/>
    <dbReference type="EnsemblBacteria" id="EGN41732">
        <property type="protein sequence ID" value="EGN41732"/>
        <property type="gene ID" value="HMPREF0994_01694"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1849"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="10">
        <location>
            <begin position="40"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGN41732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="226" mass="25573" checksum="5570E69523875D91" modified="2011-09-21" version="1">MKQKERIETILGLLDQHYGTDIICYLDHENAWQLLIATILSAQCTDARVNVVTKDLFRKYTGVKAFAKADLKELEQDIRSTGFYHNKAKNIIACCQDLMNKFDGQVPESIEDLTSLAGVGRKTANVIRGNIYNEPSIVVDTHVKRISFRLGLTKEEDPVKVEFDLMKVLPKDHWILYNLQIIALGREICKAPTAKCEECFLTEYCPYYKKNAGKQAPAKKKSGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7E3</accession>
    <name>F7K7E3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251685.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01772"/>
    <dbReference type="EnsemblBacteria" id="EGN41585">
        <property type="protein sequence ID" value="EGN41585"/>
        <property type="gene ID" value="HMPREF0994_01772"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1933"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="407"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="512" mass="59581" checksum="6DF633E6307CAC0C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7W6</accession>
    <name>F7K7W6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RpiB/LacA/LacB family sugar-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02012"/>
    <dbReference type="EnsemblBacteria" id="EGN41417">
        <property type="protein sequence ID" value="EGN41417"/>
        <property type="gene ID" value="HMPREF0994_02012"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2207"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="142" mass="14985" checksum="DB0DE1999A9EF49D" modified="2011-09-21" version="1">MLVALGSDHGGYDLKQEVIGYLKEKGIAFKDFGCMGKESCDYPEYGRAAAEAVAGGECDMGIVICTTGIGISIVANKVKGVRCALCADTVSARLTREHNDANMLAMGAGIIGKNLALGIVETFLNTPFSGEEKHARRVKAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Z6</accession>
    <name>F7K7Z6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic-di-AMP phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-&gt;5')-adenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="ChEBI" id="CHEBI:138171"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GdpP/PdeA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251956.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02043"/>
    <dbReference type="EnsemblBacteria" id="EGN41448">
        <property type="protein sequence ID" value="EGN41448"/>
        <property type="gene ID" value="HMPREF0994_02043"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2241"/>
    <dbReference type="eggNOG" id="COG3887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018278_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106409">
        <property type="term" value="F:cyclic-di-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014528">
        <property type="entry name" value="GdpP/PdeA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026583">
        <property type="entry name" value="YybT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DHH" evidence="4">
        <location>
            <begin position="366"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="5">
        <location>
            <begin position="545"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR026583-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="683" mass="76927" checksum="F7B8E4CDFE33DC17" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8E7</accession>
    <name>F7K8E7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252040.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02127"/>
    <dbReference type="EnsemblBacteria" id="EGN41034">
        <property type="protein sequence ID" value="EGN41034"/>
        <property type="gene ID" value="HMPREF0994_02127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085966_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="27809" checksum="DE899D063DAD7130" modified="2011-09-21" version="1">MSGWIDIHSHVLPLVDDGAESVEMALLMLRTAAEEGIEKIILTPHQKADRRCVTPEGILHRMKELQELAVKEHIPVRLYPGNEIFYRHGLPELLEQGKIRTLADSRYALIEFLPGEDYSYIRDALGRVASFGYWPILAHVERYANVINRMDKAVGLKEDTGCYFQVNAASITGEYGFTAKKVTRKLLREELVEFIATDAHRNEGKRSPKMKTCAEWVEKKMGREQAEKIFRRNPEAILADQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K907</accession>
    <name>F7K907_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HMPREF0994_02336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252237.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02336"/>
    <dbReference type="EnsemblBacteria" id="EGN40993">
        <property type="protein sequence ID" value="EGN40993"/>
        <property type="gene ID" value="HMPREF0994_02336"/>
    </dbReference>
    <dbReference type="GeneID" id="29726325"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2555"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="9">
        <location>
            <begin position="749"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN40993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1023" mass="116958" checksum="11DE89A81CC282B2" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K915</accession>
    <name>F7K915_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252245.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02344"/>
    <dbReference type="EnsemblBacteria" id="EGN41001">
        <property type="protein sequence ID" value="EGN41001"/>
        <property type="gene ID" value="HMPREF0994_02344"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2565"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="204"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN41001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="340" mass="38444" checksum="159837FA8224FB22" modified="2011-09-21" version="1">MRYPSFLQKQGTIGFVAPSFGCAEPPYKTAFLHAQEKLAESGYKLELGPNCYAREGIGISNTPEKCGEELNDFLCSDKSDVLISCGGGELMCEVLDYVDFDRIRKAEPKWYMGYSDNTNLVFLLTTLCDTAAVYGPCAGSFGMEPWHESIQDALDLLRGKKLVMKGYDTWEKEPLKSEENPLVPYHLTEKRILRCFPEGDSSFSGRLIGGCMDCLVNLLGTCYDRVGDFTRRYEEDGFIWFLEACDLNVFSIRRAIWQMQHAGWFSHVKGFLIGRPLVFGQEMMGLDQYHAVYDLLKEYQVPVIMDVDLGHLPPMMPLINGSFASVTVRGNELEVKMELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7K976</accession>
    <name>F7K976_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="7">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_02420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02420"/>
    <dbReference type="EnsemblBacteria" id="EGN40819">
        <property type="protein sequence ID" value="EGN40819"/>
        <property type="gene ID" value="HMPREF0994_02420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2652"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089926_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN40819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="191" mass="21920" checksum="659FD7086341612A" modified="2011-09-21" version="1">MRYHNITKDDMLNGDGLRVVLWVSGCEHCCRECQNPITWDPEGGLPFDEAARQEIFQQLDKPYISGITFSGGDPLHPANKGDVRKLMKEIREKYPDKTIWLYTGDVWEHLYKDSILQYVDVLVDGEFEIEKKDVKLMWKGSSNQRVIDVQASLKQENPARPVLHCPDYASAEDAWQDTSDGQNERRTGCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9A1</accession>
    <name>F7K9A1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrescine transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252347.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02446"/>
    <dbReference type="EnsemblBacteria" id="EGN40845">
        <property type="protein sequence ID" value="EGN40845"/>
        <property type="gene ID" value="HMPREF0994_02446"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2680"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_1_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363817" evidence="2">
        <location>
            <begin position="27"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="353" mass="40280" checksum="D9C378D9124658B7" modified="2011-09-21" version="1">MKKCLSLLLALSLAVLPLTACGSASAASNGEVVVYNWGEYIDPETISMFEEETGIKVIYDEFETNEIMYPKIEAGASKYDVVCPSDYMIQKMIENDLLAELNYDNIPNAKKNIGEQYWEQSKQFDPENKYSVPYCWGTVGILYNKTMVDDPVDSWSILWNEKYQDNILMQDSVRDAFMVALKLNGYSMNSTNPDELNAARDSLIAQKPLVQAYVIDQVRDKMIGNEAAIGVIYSGEAIYTQRENPDLEYVVPKEGTNVWIDSWVITKNAPNMENAEKFIDFMCRPEIALKNFEYITYSTPNDAARDLIEDEDIRNSKIAFPNLDEYNNLETFTYLGDDADSLYNELWKEVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9C9</accession>
    <name>F7K9C9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252382.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02481"/>
    <dbReference type="EnsemblBacteria" id="EGN40880">
        <property type="protein sequence ID" value="EGN40880"/>
        <property type="gene ID" value="HMPREF0994_02481"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2720"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="287" mass="33194" checksum="A1736E84E7588125" modified="2011-09-21" version="1">MEWTDKLQAIIDYVENHLQRTEEPVNPDEISRLAGCSYSFFQKVFSYMNGISFADYIRFRKLTLAGYDLKSTQSKVVDISYKYGYESPTSFTKAFKQFHGISPAQSRNEEAQLKVFPKMKAAVNRQYSWRLISGAPFRLVGRRTKINCSNGQQYSKVPEFWSKCQKDGTIAELLAMDNGNPKGLYGLFGYLDEASETSDYMIAVESTQQADDGYNEILIPDTTWAVFDCRGAVPQAIQDGWKYLTEEWLLKYPFRHADCPELEWYSEGNNYDENYLSQIWIPIIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9L5</accession>
    <name>F7K9L5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252487.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02586"/>
    <dbReference type="EnsemblBacteria" id="EGN40985">
        <property type="protein sequence ID" value="EGN40985"/>
        <property type="gene ID" value="HMPREF0994_02586"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="55"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="264" mass="29135" checksum="2631E5597A140414" modified="2011-09-21" version="1">MRKSLFFKIAGQLICILATALFLFPLVLMLIRSFKGEGLHNYVRVFETVNLAPNFLTSITVVFGTLLIVSAVAAMAAFAFSKLDFPFKKAIYYMLLTGMMIPTSALIFPLFQIVKGLKINNTPFSLIFPYATLNCCFNLMVLKNYFDALPNELMESARIDGAGKGRIFISIMMPIAVPGLAFVLIQTFLSAWNELQMAMIFINDTSLQPISVVPLRFTQTAGVQGFPLEVMYAALVICLSPIAVFYVFGSRFLIAGLTQGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9P5</accession>
    <name>F7K9P5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02572"/>
    <dbReference type="EnsemblBacteria" id="EGN40971">
        <property type="protein sequence ID" value="EGN40971"/>
        <property type="gene ID" value="HMPREF0994_02572"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="74"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="412"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="327"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="444"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="746" mass="85151" checksum="06514291EEDB376B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KA08</accession>
    <name>F7KA08_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3837 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02691"/>
    <dbReference type="EnsemblBacteria" id="EGN40674">
        <property type="protein sequence ID" value="EGN40674"/>
        <property type="gene ID" value="HMPREF0994_02691"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DKW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2273174_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024212">
        <property type="entry name" value="DUF3837"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038406">
        <property type="entry name" value="DUF3837_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12939">
        <property type="entry name" value="DUF3837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3837" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="105" mass="12198" checksum="ABEDF5068E9628D2" modified="2011-09-21" version="1">MVPSLARMSVIIKSQHETSVMTGNYEMAYICGLLCRLTGTVPPSLETPVQLQEDMMKLLENYSPEDDREKVVIKMLKFYKPDGLLDDQVRELYRMGLEEKTPWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAC0</accession>
    <name>F7KAC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252647.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02746"/>
    <dbReference type="EnsemblBacteria" id="EGN40355">
        <property type="protein sequence ID" value="EGN40355"/>
        <property type="gene ID" value="HMPREF0994_02746"/>
    </dbReference>
    <dbReference type="GeneID" id="29726952"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084439_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="29323" checksum="3B4AF2B4DBEAE80D" modified="2011-09-21" version="1">MRTIDKIFEELKEMTDGQRWDEVEPFLTGCLDEAREEENYGIYIGTGNELLRFYRETEQFKKALDLSEDLLLLMEELQLDETEHFATVMLNVAAACQAAGRAEEARRYYVRALKILESKPETEEVRADIFTQMALLFMNQDNYEEGEAMLKQALPLYEQLADVQETDREREMNRHIHYSTVLSGLGEASYRRKDYADALSYYEKAAALSQKCFGESEGTRLLRENCASIARQLGDEEKSAYYIGLNRKEEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAF3</accession>
    <name>F7KAF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252680.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02779"/>
    <dbReference type="EnsemblBacteria" id="EGN40388">
        <property type="protein sequence ID" value="EGN40388"/>
        <property type="gene ID" value="HMPREF0994_02779"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3040"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="253" mass="28292" checksum="91A3266D79E5E41E" modified="2011-09-21" version="1">MNVVIITGASSGIGREFALQLDAGLYTVDEFWLIARREERLEELAARLDHMAKVIPMDLTSDADMDHFRKLLKKERPVIRMLINSSGYGMMGNFNRLGRQEQLGMLDINCRALTDMTYACIPYMKRKSRIIMMASSAAFLPQPGFAVYAASKAYVLSLSRALREELGPEEIYVTAVCPGPVRTEFFEKAEKHEDTLAIKKYSMVEAEDVVRSALTASARNQGMSVYSPLIKGLHLLTKVVPHGVLLGVVQKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAP2</accession>
    <name>F7KAP2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">minC</name>
        <name evidence="6" type="ORF">HMPREF0994_02868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MinC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252769.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02868"/>
    <dbReference type="EnsemblBacteria" id="EGN40477">
        <property type="protein sequence ID" value="EGN40477"/>
        <property type="gene ID" value="HMPREF0994_02868"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3137"/>
    <dbReference type="eggNOG" id="COG0850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048711_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <feature type="domain" description="MinC_C" evidence="5">
        <location>
            <begin position="110"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="240" mass="26599" checksum="6B1EBC0E4A0DC289" modified="2011-09-21" version="1">MKNAVIVKSFRNGLTLYLDSDLDFGQLLEEVAGKFKESKEFFSDASVAVSFEGRELSFEEEDSLIETIRINSHLNITCIVGKDEEKNRIYGKALEEFRRKGCEEESVGQFYRGTLRRGQILETESSIIVLGDVNPGSSVIAAGDIVVLGSLRGNAYAGGNGRPGHYIAALEMAPQKIKIGDFKYIANEKSKWTFGTHGLYGLHGNDRNAGHAPKIQPQTAYVEKERIILKPITNELLNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAT7</accession>
    <name>F7KAT7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02966"/>
    <dbReference type="EnsemblBacteria" id="EGN40344">
        <property type="protein sequence ID" value="EGN40344"/>
        <property type="gene ID" value="HMPREF0994_02966"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3238"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_62_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="10203" checksum="9D104EE46BE717CC" modified="2011-09-21" version="1">MMDYVVIMRGLREDNDVKQREVAEYLNIDQRVYSRYERGQNAMPVRFIPLLCDYYNVSADYLLGRSKEKDYLGADKSRKLGATKKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAX8</accession>
    <name>F7KAX8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252908.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03007"/>
    <dbReference type="EnsemblBacteria" id="EGN40327">
        <property type="protein sequence ID" value="EGN40327"/>
        <property type="gene ID" value="HMPREF0994_03007"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3283"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4978">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065103_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="295" mass="35078" checksum="AA0F33E9DADC75C4" modified="2011-09-21" version="1">MKDYYTISEISKLYGIGTDSLRYYEEIGALEPKRGKNNYRLYRLKDICRLNTIRDLLQLGFSMKQVKAYLDDMNLENTLRMLEDEKKTIREQQEQLRLVEKSIERRMEHIQKYRGTEENFYRLICCPDRYCLRLDEDITRDEEVDFAIKRLQKRHEDKIRSIGDQNFGASLSPEDVRNGVYNLFHSVFFILRDGECGEGKVQLREGVSQEGYDFLLSEGTYLSTFYRGEYRQSPQRALALLEEASRRGLEIMGDILELYPVDNRYTMKTEEFVTELQIRVKERNQKRMKKQPSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAZ6</accession>
    <name>F7KAZ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-rhamnose isomerase</fullName>
            <ecNumber evidence="3">5.3.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rhaA</name>
        <name evidence="4" type="ORF">HMPREF0994_03025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-rhamnopyranose = L-rhamnulose</text>
            <dbReference type="Rhea" id="RHEA:23160"/>
            <dbReference type="ChEBI" id="CHEBI:17897"/>
            <dbReference type="ChEBI" id="CHEBI:62346"/>
            <dbReference type="EC" id="5.3.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rhamnose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252926.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03025"/>
    <dbReference type="EnsemblBacteria" id="EGN40202">
        <property type="protein sequence ID" value="EGN40202"/>
        <property type="gene ID" value="HMPREF0994_03025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3304"/>
    <dbReference type="eggNOG" id="COG4806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052790_0_0_9"/>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00541">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009308">
        <property type="entry name" value="Rhamnose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06134">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01748">
        <property type="entry name" value="rhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="418" mass="47705" checksum="B72FA55D9FD4A7C6" modified="2011-09-21" version="1">MNVKERYESAKEMYAAVGVDTDKAVETLEKIAISMHCWQGDDVTGFDQKGPLTGGIQATGNYPGKARTPEELMADIDKVFSLVPGKHKLNLHASYAIFEDGEFADRDKLEPKHFKKWVDFAKERGIGLDFNPTFFSHSKVVDGLTLSSPIDEVRNFWIEHGKACVRISQYFAEELGIPCAMNIWIPDGYKDIPADRMGPRARFKDSLDQILSIPYDKSKVLVCLESKVFGIGLESYTVGSSEFTINYAANNDIISLMDNGHYHPTELVSDKISSMLLFNEKIALHVTRPVRWDSDHVVLFDDETREIAKEIVRNDAIDRVLLALDFFDASINRISAWTVGMRNMQKALLYALVSPNKKFKELQDTNQFTELMAMQEEMKIYPFGDVWDYFCEKNNVPVKGEWFKEVKKYEEEVLSKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBP9</accession>
    <name>F7KBP9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfoX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253188.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03287"/>
    <dbReference type="EnsemblBacteria" id="EGN40117">
        <property type="protein sequence ID" value="EGN40117"/>
        <property type="gene ID" value="HMPREF0994_03287"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3593"/>
    <dbReference type="eggNOG" id="COG3743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163277_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007077">
        <property type="entry name" value="TfoX_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04994">
        <property type="entry name" value="TfoX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="88" mass="10162" checksum="4F362256BB1FED66" modified="2011-09-21" version="1">MGELSKLPNIGKIVEEQLNQVGIYTEEQLARLGSRQAWLKIQSIDSSACINRLMGLEGAIRKIKKTELPEDVKKELKEFYQEHKLPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBW5</accession>
    <name>F7KBW5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253263.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03362"/>
    <dbReference type="EnsemblBacteria" id="EGN40192">
        <property type="protein sequence ID" value="EGN40192"/>
        <property type="gene ID" value="HMPREF0994_03362"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3674"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_6_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="264" mass="30566" checksum="F8B0FA2380119210" modified="2011-09-21" version="1">MITVGHCGYDSKHRTHLEMRRPCGTPDYTLLLVKTNAFFSIKGERMLTLPGTVILYDKNVPVHYGSTGLLFNNDWIHFLPDETDLPFLLGLEIPFSTPLSLPYMAQLSEYARMIVIEKHTDHPYREQIINSLMHALLYSLASQLKDPEDKVMTNKYYPVMNDLRMSILNTPHKKWTVEAMAEYVHLSPSYMQHLYRELFGISCIQEVIQARLGTARFYLRTTDISVQSIAALCGYDNELHFMRQFKKFTDMTPSQYRSSLPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBY6</accession>
    <name>F7KBY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253228.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03327"/>
    <dbReference type="EnsemblBacteria" id="EGN40157">
        <property type="protein sequence ID" value="EGN40157"/>
        <property type="gene ID" value="HMPREF0994_03327"/>
    </dbReference>
    <dbReference type="GeneID" id="29728937"/>
    <dbReference type="eggNOG" id="ENOG50326S9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363884" evidence="2">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="251" mass="27064" checksum="7A3D04C581580B02" modified="2011-09-21" version="1">MKNKYFVSLAAAAVAALFCLMPVKADAAELINSDEYGEVLVVDVPGGEGLLFLGNTSGEVMQFLKESAGDPYFVRYNVMDATLAKVKATASSILVFDDEGELTGVKGPAEIGQDIAGHQAMIEALNNIDPQKQADLENQQLMSIAAQQKELQEAKEEALEQNRQALAAGNAGDAAQYQFMAALCDQLLAVAAAKQQAVLLYQQQAVTEAQQVLLTIQDLAGVIQQEIADYSLQYQQALSQTVMRELLQSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCN5</accession>
    <name>F7KCN5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_03614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39209.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360209.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03614"/>
    <dbReference type="EnsemblBacteria" id="EGN39209">
        <property type="protein sequence ID" value="EGN39209"/>
        <property type="gene ID" value="HMPREF0994_03614"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN39209.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="592" mass="66865" checksum="CE4A7BA5A51DF506" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCT0</accession>
    <name>F7KCT0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253560.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03659"/>
    <dbReference type="EnsemblBacteria" id="EGN39031">
        <property type="protein sequence ID" value="EGN39031"/>
        <property type="gene ID" value="HMPREF0994_03659"/>
    </dbReference>
    <dbReference type="GeneID" id="29728674"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033296_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="323" mass="37242" checksum="FB5A11810171155B" modified="2011-09-21" version="1">MTHRERFIKTLKCEKIGGQVPTFELVFFLTMEAFGKVHPSHRFYEQWNQMSSRERKLHIEDMADIYIATAKRFDHSAIFIHPNPGDLDSTQWLLETIREKTGDEYYIMMHGDPTWAIPDGDSMMDFAAQMYEEPEVLNEESKKRLDNSLKFAAGLDARGHLLDGFALCSDYCFNVNPFFNSEQFDELIVPYLKEVIAEYRKMGYYTIKHTDGNIMPIVKQMADCKPDAIHSLDPQGGVDLTEVRKIAGENIALIGNVNCGLLQTGTDEECRQDVLRALRQGMEAGKGYVFATSNCVYTGMALERYEMMLDIWREYGNYDNYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCZ2</accession>
    <name>F7KCZ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_03721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03721"/>
    <dbReference type="EnsemblBacteria" id="EGN38885">
        <property type="protein sequence ID" value="EGN38885"/>
        <property type="gene ID" value="HMPREF0994_03721"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4061"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN38885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="299" mass="34015" checksum="04932B97879AE56A" modified="2011-09-21" version="1">MRKHNKIREGSPVATAILYLLLILICIVTVYPMYYVLILSISDPKAALTMDVYLLPKGFSLAAYQMMVTDSEIWRAYLNTILYTVPTTVLMLITSILVAYPLTYKRLMGRKFVNMFLLIPMYFGGGMIPTFLVITKLGLYGSPLSQIIPACFSIWNIILMKAFFSGIPEGMREAAKIDGAGMVRILTDVYLPLSKPIMAVIAVYTIVGMWNSWFNALLYLPKVDWQPLQIFLRRILVENTRQVTNVLDPNMAAEMARRQMSGAQLKYAMIIFTTLPILFTYPFFQKYFVKGVMLGSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD32</accession>
    <name>F7KD32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253662.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03761"/>
    <dbReference type="EnsemblBacteria" id="EGN38826">
        <property type="protein sequence ID" value="EGN38826"/>
        <property type="gene ID" value="HMPREF0994_03761"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4105"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="358" mass="39195" checksum="655EBFA117AC6F39" modified="2011-09-21" version="1">MKTMKIGIVGCGGIANGKHLPAIKRNGNFEAVAFCDLIEERAVKAKEEYGTPDARVYTDYQELIKEDLDAVYVLTPNNAHAPVTIAALKAGKHVMCEKPMAKTYAEAKEMVETAKETGKILTIGYQNRYRPDSQYLKRACANGDLGDIYYAKAHAIRRRAVPTWGVFIDEEKQGGGPLIDIGTHALDLTLWMMDNYEPESVSGSVFRKLADQTETGNAWGDWDPEKFTVEDSAFGFIKMKNGATIVLESSWAINSLDVGEAQTSLCGTKAGADMADGLRINKVEYGRQCVETPDFSAGGVAFFDGAAEKADDVEQRIFYNAVVNGEPLTVKPEQALVVTQILEAIYEAAKSGKTVYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDA3</accession>
    <name>F7KDA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253733.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03832"/>
    <dbReference type="EnsemblBacteria" id="EGN38597">
        <property type="protein sequence ID" value="EGN38597"/>
        <property type="gene ID" value="HMPREF0994_03832"/>
    </dbReference>
    <dbReference type="GeneID" id="29729392"/>
    <dbReference type="eggNOG" id="COG3194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143351_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="137" mass="16061" checksum="35537344D1F8880E" modified="2011-09-21" version="1">MDEIKMLKIEKEGYQPLHQFHDWKIAGLRYAEHFDDRHLTRLERHWGTDEVFILLTGQAALLTSSGDADQLKVSVHIMEQGQIYVIPRNIWHHILCDMHAEVLIMEEADTGAENSEYRMLDLPDIHKVQTEWEARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDC0</accession>
    <name>F7KDC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253753.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03852"/>
    <dbReference type="EnsemblBacteria" id="EGN38617">
        <property type="protein sequence ID" value="EGN38617"/>
        <property type="gene ID" value="HMPREF0994_03852"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4193"/>
    <dbReference type="eggNOG" id="COG5658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155106_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="133" mass="15119" checksum="AF08308AB55DAEB9" modified="2011-09-21" version="1">MGFWIYMFLMDLLIPICMFGFGKRFQSRPPREINSVVGYRTSMSMKNEDTWQFAHHYMGRIWKISGIVTGAITLVVFLFLYGKGEDTVGTVGGVLCFIQMIPLIGVVAPTEKALHKAFDKDGKKCLSQKRKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDH0</accession>
    <name>F7KDH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253808.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03907"/>
    <dbReference type="EnsemblBacteria" id="EGN38672">
        <property type="protein sequence ID" value="EGN38672"/>
        <property type="gene ID" value="HMPREF0994_03907"/>
    </dbReference>
    <dbReference type="GeneID" id="29729478"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4251"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363912" evidence="2">
        <location>
            <begin position="24"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN38672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="556" mass="62337" checksum="FED8C042B6A841EA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE31</accession>
    <name>F7KE31_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">HMPREF0994_04110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36903.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04110"/>
    <dbReference type="EnsemblBacteria" id="EGN36903">
        <property type="protein sequence ID" value="EGN36903"/>
        <property type="gene ID" value="HMPREF0994_04110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN36903.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="187" mass="21569" checksum="3A0545D4D4EEE91C" modified="2013-09-18" version="2">MDMTRASKKLSYLLRHDKDFIDEHGWAPVTEVIHTLKKEWPEFNEECLSEIVRTDEKGRYSYDEAGVRIRANQGHSVPVDVELKEAEPPEILYHGTADRFLNAIMEEGLTGRSRIYVHLSSTTETAVNVGKRHGKPVVLKIYAGRMRDAGYKFYLSQNQVWLTQKVPVEYIETLYPEQGTENKERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE36</accession>
    <name>F7KE36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04115"/>
    <dbReference type="EnsemblBacteria" id="EGN36908">
        <property type="protein sequence ID" value="EGN36908"/>
        <property type="gene ID" value="HMPREF0994_04115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4488"/>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048266_5_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="78" mass="9187" checksum="B3CBAB3B9EF0833A" modified="2011-09-21" version="1">MANDNTILIYQDENEITKISVRFADEDLWLTQNQLAEIYDTTQQNISQHIEGIYQDKELDRKATNKKFLLVRNENVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE39</accession>
    <name>F7KE39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04118"/>
    <dbReference type="EnsemblBacteria" id="EGN36911">
        <property type="protein sequence ID" value="EGN36911"/>
        <property type="gene ID" value="HMPREF0994_04118"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4491"/>
    <dbReference type="eggNOG" id="ENOG5030G67">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137287_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="173" mass="20708" checksum="61B18C25CE91C9A9" modified="2011-09-21" version="1">MKQEKLTDIITDQTERALWEVKNVIDCVPDEYWDKEYCGMPVWKHIYHMLHSLDLWFINPRDRDFKEPSIHVENLNNLDVVSDKHLEREEIDTYYFQIREKTDEYVCSLKDGRLLEKPEGYEYTKFTLILAQFRHLHTHMGMIMGFIVAETGLWPRVAGLEGAILQGDYDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEB5</accession>
    <name>F7KEB5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254095.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04194"/>
    <dbReference type="EnsemblBacteria" id="EGN36474">
        <property type="protein sequence ID" value="EGN36474"/>
        <property type="gene ID" value="HMPREF0994_04194"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4575"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN36474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="280" mass="31610" checksum="08F1D524FF8D320E" modified="2011-09-21" version="1">MAKAIKRYWPIFVLPTFLAFILGFIAPFIMGIYLSFCKFTTVTDAKFIGFSNYLKIFTDPSFVHALWYTALFTVVSVILINVLAFTVALLLTKGFKGTNVFRTVFFMPNLIGGIILGYIWQLLLNGILLYFNRTLTYSSTYGFWGLIVLMCWQQVGYMMIIYIAGIQNISGDLIEAAKIDGANSRQILRNVTIPMVMPSITICTFLTLTNSFKLFDQNLALTNGEPSKMSEMLALNIYNTFYGRTGWEGVGQAKAVVFFILVAIIALAQNKLTRRKEVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEC8</accession>
    <name>F7KEC8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM_X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254108.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04207"/>
    <dbReference type="EnsemblBacteria" id="EGN36487">
        <property type="protein sequence ID" value="EGN36487"/>
        <property type="gene ID" value="HMPREF0994_04207"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4592"/>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019054_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11754">
        <property type="entry name" value="GH94N_CBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037825">
        <property type="entry name" value="GH94N_CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="809" mass="90796" checksum="4A1258638304B841" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEU6</accession>
    <name>F7KEU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myosin-crossreactive antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254280.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04379"/>
    <dbReference type="EnsemblBacteria" id="EGN35689">
        <property type="protein sequence ID" value="EGN35689"/>
        <property type="gene ID" value="HMPREF0994_04379"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4778"/>
    <dbReference type="eggNOG" id="COG4716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024043_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="589" mass="67345" checksum="30EB7E5B76E2B94D" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEZ3</accession>
    <name>F7KEZ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04429"/>
    <dbReference type="EnsemblBacteria" id="EGN35739">
        <property type="protein sequence ID" value="EGN35739"/>
        <property type="gene ID" value="HMPREF0994_04429"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4837"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118650_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN35739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="206" mass="24051" checksum="D0BE35ACE64F4744" modified="2011-09-21" version="1">MPKISDEKKKQRQTDILKTALKLFSQKGYYATSIDDITREAGISKGLIYNYFKSKEEIFFELAEHWNEFMNNPSFEDALSRVISEDMSLSEKLICVWDETVNQWTAENLDFAGIKFEFWLESSKNEALRDKMKEKAKNSLSIVEEIIYKTKPDIDPGIAAAFSRLWWSQIDGLVAYFVSYHILPPPDEMAQIRKIILHQCKYLDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFS6</accession>
    <name>F7KFS6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254606.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04705"/>
    <dbReference type="EnsemblBacteria" id="EGN34631">
        <property type="protein sequence ID" value="EGN34631"/>
        <property type="gene ID" value="HMPREF0994_04705"/>
    </dbReference>
    <dbReference type="GeneID" id="29727267"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5137"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363742" evidence="1">
        <location>
            <begin position="31"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="437" mass="47590" checksum="F1871089CFC75CAA" modified="2011-09-21" version="1">MKKKALSILLTAAMAVTMLAGCGSSSSDNAAGSGAATGDTAAQSEAAGNEAAAGGDKTVINFYYSTDLEKVATKEMEAFNAANSDIEVVGHSIAEGDYDDKVKVMTAGGSTDADIYWVRTPAQMAQYTANGAFVDLAPYAESTGVDLSPIKDTSLAGVTDANGAFYGYPTSGSCWMMFYNKELFDAKGIDYPENLTWNEYLDLIKELTGEEDGTKYWGGLMPIWTPNLGAIPTGEYLDDENLTKTKEFAQIQHRMYVEDASAPGIAEMTSGTFDITAYFQAGNIYTMINGDWMFRLMEADFEWGAAPLPIFEGEEEGSSVGQSSYLVISSTSKHPDEAYKFIEFYCTSPEGTAIIAENCDVPSYTTDEALEVFKSQVNVPGVDYRFSAKIKDEQKGEEGYASLIEAYNQELQLYLLDEQSLDETFSNYAELRDEIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG72</accession>
    <name>F7KG72_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WxL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254756.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04855"/>
    <dbReference type="EnsemblBacteria" id="EGN34482">
        <property type="protein sequence ID" value="EGN34482"/>
        <property type="gene ID" value="HMPREF0994_04855"/>
    </dbReference>
    <dbReference type="GeneID" id="29727729"/>
    <dbReference type="HOGENOM" id="CLU_067278_5_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027994">
        <property type="entry name" value="WxL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13731">
        <property type="entry name" value="WxL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363747" description="WxL domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="WxL" evidence="2">
        <location>
            <begin position="45"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="202" mass="21266" checksum="189FE8C6661B208D" modified="2011-09-21" version="1">MDKTKQIGKKIPLFALLAVMILTMTNQPVQAAAVGDSTTGDTQAVVSFKAGDLKLQAAPALDFGQHEISAAVQVYTAESVGDSVRISDLRGSGEGWSLTVALSKFQLKEDGGETLAGAVINTSAPTVKTNAENLGKPPVQVTEIELTSDGTVTRVWNAEEKSGMGVWELEWIAGNTTLTVYPGTAEEGDSEAVLTWNLQSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG80</accession>
    <name>F7KG80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254765.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04864"/>
    <dbReference type="EnsemblBacteria" id="EGN34491">
        <property type="protein sequence ID" value="EGN34491"/>
        <property type="gene ID" value="HMPREF0994_04864"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="281" mass="31646" checksum="485940CCE068BDA6" modified="2011-09-21" version="1">MKLTKRNAVQFLLYLLLTAGLVIVVIPFCYMISTSLKPNGALYEFPPHFFPSLKEITLENYDYILHQGKFYMNFLNSVLVSGITVAIAAFVAAALGFCIARFRFPGRSFLFLFIMLTMIIPGTTLIVPQYELAVKLKVINNLWGLIPFYVAWVIPYSTFMIKGFVENVPKELDEAIYMDGGGVFTVFFRIVFPLAKPGIASVSIFNFLTAWEEFPWANTVINDNLKRTLPIAISGFFGQHQFTQWGYVFALSVLSLLPILIIFIFCQKFFVAGLTAGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGD4</accession>
    <name>F7KGD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254814.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04913"/>
    <dbReference type="EnsemblBacteria" id="EGN34203">
        <property type="protein sequence ID" value="EGN34203"/>
        <property type="gene ID" value="HMPREF0994_04913"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5366"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="25879" checksum="CBCAA34B638360D3" modified="2011-09-21" version="1">MAFVEFKNVKKVYHMGEVDIHALQDVNFEIQEGEFCVIVGASGAGKTTILNILGGMDTLSEGQVILDGKEISAYNQRQLTSYRRYEIGFVFQFYNLIQNLTALENVELASQISRNPLDAGETLKKVGLEERMSNFPAQLSGGEQQRVAIARALAKNPKLLLCDEPTGALDYNTGKAVLKLLQDTCRETGMTVVVITHNQAITAMADRIIRVKSGTIRSMEMNPHITPVEEIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGJ6</accession>
    <name>F7KGJ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TelA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254876.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04975"/>
    <dbReference type="EnsemblBacteria" id="EGN33770">
        <property type="protein sequence ID" value="EGN33770"/>
        <property type="gene ID" value="HMPREF0994_04975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5434"/>
    <dbReference type="eggNOG" id="COG3853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036971_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="380" mass="42756" checksum="7608BF1043AD8929" modified="2011-09-21" version="1">MGDFSLDLPRTEEIKKEVEKELAPTNEDKALIDNTMKEKAEMIMGVDLDSLAERREFVQVIETFGADIIKKSSVKNSILQKRMGDFSKAGGETSEISRGLADLSIKMRDLDPSALDFTKTGPLGKIFNPIRRYFERYKTADAEIASIVKTLDKGKNMLKNDNTTLEIEQADMRDLTKQLAQRIEMGTQLDMYLSNAVENAEAAGEDEEKIKFIKEEILFPLRQRLMDFQQLLVVNQQGIIAMEVIRKNNLELIRAVDRAETVTISSLRVAVTVAGALYNQKIVLEKVQMLNETTNNMILSTSKMLKEQGVAIQREAVEASISPDTLKQAFADTISALDDISAYKAKALPQIARTIEEFKEIAVEGEKQLQKLEKSRNVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGP5</accession>
    <name>F7KGP5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_05024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05024"/>
    <dbReference type="EnsemblBacteria" id="EGN33819">
        <property type="protein sequence ID" value="EGN33819"/>
        <property type="gene ID" value="HMPREF0994_05024"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5487"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_31_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="14"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="411" mass="45697" checksum="806E20BE8FA74397" modified="2011-09-21" version="1">MINRLTSRRDIRFLSFLCCLVYFVSYLTRLNYAACLAEVQRSLNISKSLAGLPVTGCFITYGIGQLLCGFMGDRFHPRDMIFTGLTATSVCNLLAALFPRIEVIIPIWCFNGFFQSMLWPPLVRVMAEGLDEEHYKKCCVQVSVASSAGMIAVYVLAPVCIFISGWRLAFIFPGLLGIATAFFWLLSFTRLQSDGTNTVSALNVEMETDYTIKLPALFLQASLIPILLAIILHGILRDGITTWMPAYITETFGLSTSLSILTTAVLPIFSIFSITIASWLLQKLHNELFTAGILFVIGTLSSLLLLPFYQSLPVFSITMMTLITGCMYGINLLLISRVPRHFARFGRVATISGILNASTYIGSSLSTYAFGAISERFGWFYTIAVWVLVALGGALLCFITFRKWERFSNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGT2</accession>
    <name>F7KGT2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_05061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254962.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05061"/>
    <dbReference type="EnsemblBacteria" id="EGN33339">
        <property type="protein sequence ID" value="EGN33339"/>
        <property type="gene ID" value="HMPREF0994_05061"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5528"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="69"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="290" mass="31035" checksum="495659198664C296" modified="2011-09-21" version="1">MDQSILIKRVRISDYIITALIYAAASLSILLLAGIVCYTFVKGVSSISWQFLTTVPSTIKETFGIAGNLLNTLYIVIITLLIATPVGVGSAIYLNEYAKPGKIVSTIEFTTEILSGIPSIIFGLFGMVFFGTTLGFGYSILTGALTLTLMVLPLITRNTQEALKTVPESYRSGALGMGATKWYMIRTILLPSAMPGIITGIILAVGRIVGESAALLFTAGSGYLLPKSGMGFLHKILESGGTLTIQLYLCMSKAQYGEAFGIAVVLLVLVLGINMLTKYLSGKFNVETRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH94</accession>
    <name>F7KH94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002588988.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05233"/>
    <dbReference type="EnsemblBacteria" id="EGN33266">
        <property type="protein sequence ID" value="EGN33266"/>
        <property type="gene ID" value="HMPREF0994_05233"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5714"/>
    <dbReference type="eggNOG" id="ENOG502Z9RE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1774635_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028956">
        <property type="entry name" value="Imm51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15595">
        <property type="entry name" value="Imm51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="147" mass="17108" checksum="7A31D9AEA426960D" modified="2011-09-21" version="1">MKDLCQYGNRPEDEWEILPWIPDPRPPFKIWVKLEQIAPFFLIPHHPYAISLLLKISDGFRAEEFCRLGLTGSSGDWERLVRGVIREFEENNSGVDLFHFDSDEDVFCVYSQYIDDLMLLSKMIRAACDNEKTMGTYLGIGEVEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH95</accession>
    <name>F7KH95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862369.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05234"/>
    <dbReference type="EnsemblBacteria" id="EGN33267">
        <property type="protein sequence ID" value="EGN33267"/>
        <property type="gene ID" value="HMPREF0994_05234"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5715"/>
    <dbReference type="eggNOG" id="ENOG502Z7NH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091303_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025335">
        <property type="entry name" value="DUF4241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14025">
        <property type="entry name" value="DUF4241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="27418" checksum="21189E7A7D8FA260" modified="2011-09-21" version="1">MPTTEWLNKYEAIKDKLTCKDDLEAHFTEKVIGNMAVDVLDIGTVHFPTGQIFACDPLVELEDTLPFLQTIPAGTYPVKICVVPSEQYGDRYACVKVEVNQEKPVRYELGMVGNEDLDEELGEDEYFGFGVDAGMGCVADIQTQAAFKAYWAKRLEEDPDIDPYNNLFCDLLEENAKAHPKYQGDCGDWLNWTVPDTDCNLPIFASGWGDGYYPVYFGYDAKGEVCAVYVRFIDIEASYQEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHA8</accession>
    <name>F7KHA8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007862384.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05247"/>
    <dbReference type="EnsemblBacteria" id="EGN33280">
        <property type="protein sequence ID" value="EGN33280"/>
        <property type="gene ID" value="HMPREF0994_05247"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5732"/>
    <dbReference type="eggNOG" id="ENOG5032TXN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195077_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025468">
        <property type="entry name" value="TTRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041965">
        <property type="entry name" value="TTRAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14203">
        <property type="entry name" value="TTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN33280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="71" mass="8153" checksum="C5374DD7715F1DD7" modified="2011-09-21" version="1">MGNFTFEEMNLMCIYNTGSRTGLMEALTEMRGELSPEETELRELTDSALTKLCAMTDEKFAELELYPDFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHT4</accession>
    <name>F7KHT4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH gntR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05423"/>
    <dbReference type="EnsemblBacteria" id="EGN32864">
        <property type="protein sequence ID" value="EGN32864"/>
        <property type="gene ID" value="HMPREF0994_05423"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5927"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808293_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="355" mass="40480" checksum="2BA6E5C4FBF9466E" modified="2011-09-21" version="1">MNRENKEIADILRKEVKQLQSDRLIKLESERKLEQRLMVGRQRIREVINQLVSEGILIKYEGKGTYIAPIVKNKYVNLICSPSIKLNDPFYNRMLMELTSYSAKNSVNMIPLTLDTLENGDMISPVLMIGKFEEDSLQRIKKIYPHIISFENYPDHDDFAQIYFDHFKIGINAAKVLAGYGHKKVVHITGPDTYASALYRKNGFIRGSRKNGIDYVILESKMNFRGGYALADQISNLIMIRKFTAVFAANDWMAIGLIQALRTKGIEVPDQVSVLSVDNIPLASQFAPALTTYSLDANMMIAECFSLMDAAESRMGSREENNVMDEQKFHKRVILQPILITRDTLIKQDNPFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7KI63</accession>
    <name>F7KI63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255349.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05542"/>
    <dbReference type="EnsemblBacteria" id="EGN32367">
        <property type="protein sequence ID" value="EGN32367"/>
        <property type="gene ID" value="HMPREF0994_05542"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6058"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN32367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="333" mass="37231" checksum="0B0C61A91298AA92" modified="2011-09-21" version="1">MSKNVVLSVKNLRTYFDGKEGIVPAVDGISFDVHEKEVFCIVGESGCGKSVTSLSILNLIPKNSGRIMEGSSIKLQGKELTTLGDKELCDIRGKDIAMIFQDPMTSLNPVFTIGKQLTETISRHMGVDKKEAKKRAVSLLEKVGIPSPYERFHEYPHELSGGMRQRIMIAMALSCNPKVLIADEPTTALDVTIQAQILDLMLKLKDEIDTSIIMITHDLGVVADIADTVMVMYAGNTMEFGNSYQIFRNPLHPYTRGLLDSIPRLDRQVERLYSITGTVPKLHKGMKGCRFCSRCQEATEKCKEEIPPMYTISDMYGENHQVNCWKYENTVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIH1</accession>
    <name>F7KIH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255457.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN32274">
        <property type="protein sequence ID" value="EGN32274"/>
        <property type="gene ID" value="HMPREF0994_05650"/>
    </dbReference>
    <dbReference type="GeneID" id="29728806"/>
    <dbReference type="eggNOG" id="ENOG50327Y9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2553917_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="82" mass="9886" checksum="33299A360380307B" modified="2011-09-21" version="1">MTDVQWLLLLLSLLIIVPVIWSVTMSLLRKRDFKRQIEGKRPERKAKENMKISRENPEVNVNMDTERLRFEAQMKQNQRIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIP3</accession>
    <name>F7KIP3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe-ADH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255535.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05728"/>
    <dbReference type="EnsemblBacteria" id="EGN32217">
        <property type="protein sequence ID" value="EGN32217"/>
        <property type="gene ID" value="HMPREF0994_05728"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6264"/>
    <dbReference type="eggNOG" id="COG1979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="392" mass="42707" checksum="48A4C98AC5D52332" modified="2011-09-21" version="1">MLNFDLYTPARILFGKGEEKRIGELLKPHASKVLLHYGSGSIKKSGLYDTVTASLRESGISFAELGGVKPNPRLSLVHEGIALCKKENVDLILAVGGGSTIDSAKAIAMGVYYDGDIWEVYEQGKPVEKALPVATVLTIPAAGSESSGDSVITNEEKQLKFGYGSPLIRPLLSVMDPELFFTLPKNQLANGVADMMSHVFERYFTNTTHTDLTDGLCEVTLKTLMKNAPIALDDPQNYDAWAELGFSGTVAHNGLVGMGREQDWACHGMEHELSAIYDVAHGAGLAVLTPGWMQYVYKDNINMFVQFAVNVMGVEGSYRDPDAIVQEGIARLRTFFKRMGLPGTLAELGIGEDRLEEMAKKATGAAFGEESPLGGFKKLYWQDVLAIYKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIP8</accession>
    <name>F7KIP8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3502 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_05735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255542.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05735"/>
    <dbReference type="EnsemblBacteria" id="EGN32224">
        <property type="protein sequence ID" value="EGN32224"/>
        <property type="gene ID" value="HMPREF0994_05735"/>
    </dbReference>
    <dbReference type="GeneID" id="29728979"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6272"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037301_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356945" description="DUF3502 domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="382"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN32224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="517" mass="56601" checksum="C60A890C6E449DEF" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KK24</accession>
    <name>F7KK24_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN30710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255993.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06217"/>
    <dbReference type="EnsemblBacteria" id="EGN30710">
        <property type="protein sequence ID" value="EGN30710"/>
        <property type="gene ID" value="HMPREF0994_06217"/>
    </dbReference>
    <dbReference type="GeneID" id="29723627"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6809"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027430_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="4">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5597" evidence="5">
        <location>
            <begin position="368"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN30710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="537" mass="60292" checksum="F2D538D0E682F476" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKB2</accession>
    <name>F7KKB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_06291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256061.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06291"/>
    <dbReference type="EnsemblBacteria" id="EGN30210">
        <property type="protein sequence ID" value="EGN30210"/>
        <property type="gene ID" value="HMPREF0994_06291"/>
    </dbReference>
    <dbReference type="GeneID" id="29726990"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6895"/>
    <dbReference type="eggNOG" id="COG5520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014379_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="PTHR11069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glyco_hydro_30" evidence="5">
        <location>
            <begin position="43"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_30C" evidence="6">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN30210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="459" mass="52682" checksum="EC936F2578563E9E" modified="2011-09-21" version="1">MKLKWIYTARDTGERLVQKALSPVEGQEDFRFCIFPRDDRQKIYGFGGAFTDTAAMALFQMEKPIREKAMAAYFSPESGLGYNMGRVPIGCCDFSSIPYSHAEVPEDKELSHYSIAQDKKGILPLIKMAKEYMFKEERQQELFLYALPWSPPGWMKSNGKMNWGGKLLPEYYKTMADYLVKFIRAYEKEGVFLWGLAAQNEPVEVQRWASCEYTGEEEGNFLKNYLIPALDEAGYGDKKLLCWDCNKDFMRKRAQELLKDEELRRRIFGIAFHWYSGDYFEELHNTHEEFPKIQLLATECCVVMPEKMEDWSVGERYGHEIIGDMNNWTCAYLDWNLFLDQDSGPGIADNPCAAPIILDSRKQEMIKMSSYYYIGHFSRYIKRGAVALGTKLTGALSEKIPEGCAFRNPDGQLAVILMNREDMPLSGTIAIDGKYTEVNLDAHSIGTLLVDFEENLNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKC5</accession>
    <name>F7KKC5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">His_kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN30223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256074.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06304"/>
    <dbReference type="EnsemblBacteria" id="EGN30223">
        <property type="protein sequence ID" value="EGN30223"/>
        <property type="gene ID" value="HMPREF0994_06304"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6908"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="380"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN30223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="588" mass="67743" checksum="2131FA6715F30606" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKP0</accession>
    <name>F7KKP0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN48027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256181.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06419"/>
    <dbReference type="EnsemblBacteria" id="EGN48027">
        <property type="protein sequence ID" value="EGN48027"/>
        <property type="gene ID" value="HMPREF0994_06419"/>
    </dbReference>
    <dbReference type="GeneID" id="29727668"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243556_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="195" mass="22242" checksum="CC35BE0726EA6F37" modified="2011-09-21" version="1">MMEKKEGIAVYIYRMQDKRDDKSQSPLFLSRAAARYAFGEGGEGPSKEASFRVEKGLRGKPYFPEYPWLHFSISHSGDFWACAMAAQEVGLDLQQHTKGRREHISKRFFHPLENEYLKKNNYRDFFDVWAAKESYVKFTGSGIGEDFGGFSAASEDGLAKEINGIQLRSIPFSPDYSLCLCAKEIQNVSLYYENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKV6</accession>
    <name>F7KKV6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256247.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06485"/>
    <dbReference type="EnsemblBacteria" id="EGN47496">
        <property type="protein sequence ID" value="EGN47496"/>
        <property type="gene ID" value="HMPREF0994_06485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7101"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_8_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN47496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="122" mass="14197" checksum="206DF23CEBCA5621" modified="2011-09-21" version="1">MKFKFAHNNFNVKDLQKSLRFYEEALDLKPVRTKEAPDGSFTLAFLSDGTTPHQLELTWLRDWEKASYDLGDNEFHLAFTVDDMEAAHSRHKEMGCICFENEAMGIYFIQDPDGYWIEIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL05</accession>
    <name>F7KL05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">23S rRNA (-C5)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256296.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06534"/>
    <dbReference type="EnsemblBacteria" id="EGN47253">
        <property type="protein sequence ID" value="EGN47253"/>
        <property type="gene ID" value="HMPREF0994_06534"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7156"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN47253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="400" mass="45104" checksum="B8986B6C1FBBF72D" modified="2011-09-21" version="1">MYDTLVTLKKGTGRTLKSGGMWVYDNEIESIAGDFENGDLVTVHDFDGYFLGIGFINMQSKITVRLLSRKKGTVIDEAFLEKRVENAWEYRKQTVDTGCCRVIFGEADWLPGLVVDKFSDVLVVESLALGIDRLKAVILDALCRILQRDGIEVRGIYERSDAKVRLQEGMERFKGFISAPFDTKVQIEENGVKYIVDIEDGQKTGFFLDQKYNRAAVQRLCRGKKVLDCFTHTGSFALNAGIAGAESVLGVDSSQTGILQAEENARLNGLEDRVHFQCADVFELLPWLEGQGEKFDVVILDPPAFTKSRNSIKNAVKGYREINLRGMKLVENGGFLVTCSCSHFMDPELFSKTIREAAAGSHKRLRQVEFRTQCCDHPILWAADESYYLKFYIFQVCEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KL57</accession>
    <name>F7KL57_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN47309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256352.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN47309">
        <property type="protein sequence ID" value="EGN47309"/>
        <property type="gene ID" value="HMPREF0994_06590"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033A9E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1394231_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN47309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="190" mass="20996" checksum="B6DF615E71789B3D" modified="2011-09-21" version="1">MDLFDKIGNIAKNIGDRTNDAIEITKLNAKIATEKSAVAEDLKKIGEFYYKKFADEEPIDTEIQEFCDNAASHYEAIDQAQAEIERIKKENGVNKESSGQEEPKKDDEAKEEAEACEKEPEPESMVVCPNCQAVNPEGLKFCTQCGSSLEPEKAVKEEDKKETAKCPVCGEPLNKDSKFCGHCGATITPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLJ5</accession>
    <name>F7KLJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256486.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06733"/>
    <dbReference type="EnsemblBacteria" id="EGN46657">
        <property type="protein sequence ID" value="EGN46657"/>
        <property type="gene ID" value="HMPREF0994_06733"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7361"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076645_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="186" mass="21465" checksum="F91F4825A1B4B61B" modified="2011-09-21" version="1">MPEYLKFSSRSEFRNWLETNCMSDEGVWLLFGKAGGPKTIKAGEALEEALCYGWIDGQMQSLDDKSYVKYFSMRRENSKWSDKNKTIVESLEKQGLMTEFGREKIEAAKKNGQWDKPKAPPITDEQIAVLADILKEYEPAYTNFQAMSPSVKKTYTRAYYDAKTDAGRANRISWMVERLNKNLKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLN8</accession>
    <name>F7KLN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_A24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06767"/>
    <dbReference type="EnsemblBacteria" id="EGN46359">
        <property type="protein sequence ID" value="EGN46359"/>
        <property type="gene ID" value="HMPREF0994_06767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_10_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="151" mass="16587" checksum="590231FCC032794C" modified="2011-09-21" version="1">MAENLILCSFLGICSCYDLKLRKIPGWLLYTGILLGTLYWGILKMAGQVSWAALPVSLLPGCVILFYSYITEGKIGIGDGLLVMPAGLMQQWQRCTAEIIGACLLTFFLAAGLLISRKGNRNTRIPFAPFFLAAVVLVWIMEAWIGVPVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLU6</accession>
    <name>F7KLU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000006">
        <property type="protein sequence ID" value="EGN46054.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360010.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06825"/>
    <dbReference type="EnsemblBacteria" id="EGN46054">
        <property type="protein sequence ID" value="EGN46054"/>
        <property type="gene ID" value="HMPREF0994_06825"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RVM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191489_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN46054.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="65" mass="7327" checksum="146596D7F72EE8A5" modified="2013-09-18" version="2">MAKNKTEIHVTTVFDGELDATDVFVSLISQKYGKINTKEYLAKKKDMKYNEDEVQKSQIPSGLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLV8</accession>
    <name>F7KLV8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN46066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256576.1">
        <property type="nucleotide sequence ID" value="NZ_KE150409.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06837"/>
    <dbReference type="EnsemblBacteria" id="EGN46066">
        <property type="protein sequence ID" value="EGN46066"/>
        <property type="gene ID" value="HMPREF0994_06837"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7470"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_31_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="90" mass="10377" checksum="DAE7D0EB5630A291" modified="2011-09-21" version="1">MHISYKPLWHTLLERNMRKEDLRLAAGMTTNMIANMSKEGKHISMDTLARICETLNCEITDVIELVPDEPASTGGKEHERIKTKNNRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWF1</accession>
    <name>S2KWF1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_06973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359735.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06973"/>
    <dbReference type="EnsemblBacteria" id="EPC05305">
        <property type="protein sequence ID" value="EPC05305"/>
        <property type="gene ID" value="HMPREF0994_06973"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_7_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="338"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EPC05305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="482" mass="55197" checksum="3A1BEE1D8522B011" modified="2013-09-18" version="1">MINRVFNKYKNLPVQMKASFWFLICAFLQKGISMLTTPIFTRLLTTVEYGQFNVFTSWLGIITIFVSLNLSYGVYTQGLIKFNEERNAFTSSLQSLTTVLVVFWIVIYLVFHDIWNEIFSLSTVQMLALLIMIWTSSIFGFWAGKQRVLYRYRTLVIVTLGVSIAKPVIGIIFIKIADDKVTARILGLVLVELVGYTAMYFAEMIKGKKFYSAKFWKHALMFNLPLIPHYLSQTILNSADRIMISSLVGASEAGIYSLAYSISSIMTLFNTALSQTISPWIYQKIKDKKEKDVAPVAYTTMLLIAEVNLLLIALAPEAVAIFAPSSYYNAIWVIPPVAMSAYFMYCYDLFAKFAFYYEKTGFIMIASVLGAVLNIILNYFLINFYGYKAAGYTTLFCYIVYCIGHYIFMNKVCDRFCKGIRPYELKKILLITIPFLLIGFLLLLTYEHIIIRYIIIITALISVIVKREQLIAVLLRLVTLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>S2KWF9</accession>
    <name>S2KWF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_06988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359759.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06988"/>
    <dbReference type="EnsemblBacteria" id="EPC05320">
        <property type="protein sequence ID" value="EPC05320"/>
        <property type="gene ID" value="HMPREF0994_06988"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EPC05320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="347" mass="38350" checksum="3E9ABE1C1D943D0D" modified="2013-09-18" version="1">MAGTIQRIAELAGVSRGTVDRAINGRGRVNEETAARISQIADELGYVPKHRKKRAAGEQTGMPGQAKTIGVITQLCHSSFMIEVNRGISEISAKLEKQGIRVCVKESATVDEAEQLAAIDELEREGIDALALMPVDSDSIRIRLNRLVSERKIPLVTFNSDIVGTERMCFVGIDNWKSGRTAAGLMGLMMHGKGRVLGITGYFSNGAGSRRVDGFVEELKNSFPDIGLIGVQSSFDHTQEVEKIIVDAMNAYPDLGGIFVASGGQEGVKRAFERLGPETRPYVIIYDLTPKNERYLQEGVVDFLLDQEGYLQGYRAVSLLADKLRWDKEPAEEYMYTEIRIKTKYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2J1</accession>
    <name>F7K2J1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250019.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00070"/>
    <dbReference type="EnsemblBacteria" id="EGN48303">
        <property type="protein sequence ID" value="EGN48303"/>
        <property type="gene ID" value="HMPREF0994_00070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.75"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="183" mass="21145" checksum="E3E43C43CA24191A" modified="2011-09-21" version="1">MNQKNTVVLIVDVQNALMEAHPFREEELTDNLKVIIHNARQRGMEVVYVRHDGGEGDELALGTQGWQIFDAAVPQEGERIFEKRYNSAFKDTGLGEYLKEKKITEIILGGLQTEYCIDATCKSAFERGFHVWIPAHTTSTFDNDYFTAEQLTEYFEKKMWDGRYADVRPVEEIIEKMKNFPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2X1</accession>
    <name>F7K2X1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN39233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250149.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00200"/>
    <dbReference type="EnsemblBacteria" id="EGN39233">
        <property type="protein sequence ID" value="EGN39233"/>
        <property type="gene ID" value="HMPREF0994_00200"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN39233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="296" mass="33464" checksum="0813952956BEB919" modified="2011-09-21" version="1">MLRRKKKIGNEAAGYLFIAPYYLFFIYMLLLPILNTVINSFTNYDLYEKRDFVGLRNYVDLIHDSLFIQALGNTLFYSVLYIIPSMGLGLLLALLLSNEGKGFKFFRAAFYIPYVISMVCASTIWMWIFDPANGILNQILKVFGRPGGTWLKDPDIAMYCVVFVSVWKSLGYCMLINLSGIKGIPGYLYEAAQLDGANRFQRFIHITLPQLSPTTFFLFITSCISSFNVFEQVNVLTAGGPLNKTTTIVHQIYTRGFTQFKMGYASAMSVVLLLIVSIITLVNFKYGNQGKDIDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K358</accession>
    <name>F7K358_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250236.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00287"/>
    <dbReference type="EnsemblBacteria" id="EGN33428">
        <property type="protein sequence ID" value="EGN33428"/>
        <property type="gene ID" value="HMPREF0994_00287"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.310"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022800_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="684" mass="76301" checksum="7C32431F95E51E0A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3D0</accession>
    <name>F7K3D0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250312.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00363"/>
    <dbReference type="EnsemblBacteria" id="EGN33504">
        <property type="protein sequence ID" value="EGN33504"/>
        <property type="gene ID" value="HMPREF0994_00363"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.393"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071599_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="302" mass="34690" checksum="16F3DD8782E5A4DF" modified="2011-09-21" version="1">MTETKKQDAVTESEKELHRCLEQAEAVVIGAGSGLSAAAGFTYSGKRFEEHFREFIEKYGMTDMYSAGFYPFASQEEKWAYWSRHIYYNRYDQPAGTAYTQMLSLVKERNYFVITTNVDHQFSLAGFEESRIFAVQGDYGLFQCKKACHKKLYDNERQVRAMLARQKNCRIPSELVPKCPVCGGDMEVNLRCDIFFVEDEAWHHTAEGYERFIRENSGKKVLFLELGVGMNTPGIIKYPFWQLTWQNPRASYVCINLGEALAPEEIRERSLCINGDICKVISEVLKEGEKDNESDGKKMLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3D4</accession>
    <name>F7K3D4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_00367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250316.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00367"/>
    <dbReference type="EnsemblBacteria" id="EGN33508">
        <property type="protein sequence ID" value="EGN33508"/>
        <property type="gene ID" value="HMPREF0994_00367"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.397"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045786_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="500" mass="54953" checksum="12CC8DB6E2CF1B5A" modified="2011-09-21" version="1">MEKWKAPKKPRIGIYTMGLKAYWNQFPGLRERLLHYGQFISDKITALGGEVFFYGLADCEEAGRECGEYFNSHNVDLIFAHSGTYVNSSSVLPIHQICRAPVVILNLQPAARIAYDRTTTGEWLAHCGACPVPELSNAFHRSGIACRIINGLLGLDHTPGISLTEENTASRPEAIKAWKEIGEWVKAAAVKRELSGCRFGFLGNTYNGMLDMYSDFTMIQAQTGAHIEILEMCDLNRELSQVTEEEVLAKKQEILEFFLISEEKAADPLAQKPTDEQLDWSARVAAAQERLVREYGLDALTYYYHGSPGGEYEKLQSGFIVGHSLLTARGIPCAGEGDLKTCLAMKICDILGTGGSFCEIVTVDYEDGTILLGHDGPFHLAIAKGKPILRGMGLYHGKQGTGVSVEAKVRTGPITNLACTQTIDGRLKFIITEAQSTDGPIMTIGNTQTPVKFKKDPDSYMDEWFAEAPTHHFAMSVGHNASIMEKVSEILGIACVTLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3G4</accession>
    <name>F7K3G4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CitMHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HMPREF0994_00397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ArsB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250346.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00397"/>
    <dbReference type="EnsemblBacteria" id="EGN33538">
        <property type="protein sequence ID" value="EGN33538"/>
        <property type="gene ID" value="HMPREF0994_00397"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.431"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="12">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGN33538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="451" mass="48268" checksum="1204F9682B0760DA" modified="2011-09-21" version="1">MTAAQIAAVVIFLAMFGLIVSEKIERHLVSLGCGLLMIVLVFGLSMHSMTAIWNTLALKDFFAAGFWYQAGEASESSSGINWATILFIAGMMLMVEGMGRAGFFRWLCLRIAKAVKYRTIPLFITFMVMSSILAMFIDSITVILFLAAATVELARLLKFNPVPMIISEIFCANLGGSATMCGDPPNIIIGTSLGYSFGNFIRNTGIIALIALFFTIVYFYFCFRKELQQSASGRGAVSYPNPRDAIENKKDFIISCIIFACAVVLLITHAQTGLTVAAIGVFIGAVSLITAGREAVILLKKVDYKTLLFFIGLFIVVGGLEQTGILELIAGFIAKISGSNAMLMIAIVLWISAIASAFVDNIPFAATMVPVIKSLAAASGVDLSVLAWTLAMGTDIGGSATPIGASANVVGISVAAKEGHMIGWGKYCKYAAPATILVVLISMISIYIRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3I2</accession>
    <name>F7K3I2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250360.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00411"/>
    <dbReference type="EnsemblBacteria" id="EGN31926">
        <property type="protein sequence ID" value="EGN31926"/>
        <property type="gene ID" value="HMPREF0994_00411"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.451"/>
    <dbReference type="eggNOG" id="ENOG503350I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181467_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="10135" checksum="85BA112D53C90221" modified="2011-09-21" version="1">MRIIIRSKDVNMWLPVPLVLADAAVRFLPDSVMEEIRNPIPSPYREVITKELLQELVRECRNVFKEYKGLEIVHVEAQDGTFVSIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3P6</accession>
    <name>F7K3P6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00475"/>
    <dbReference type="EnsemblBacteria" id="EGN48193">
        <property type="protein sequence ID" value="EGN48193"/>
        <property type="gene ID" value="HMPREF0994_00475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.523"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054001_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN48193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="421" mass="47956" checksum="F811BD18BCE39FE7" modified="2011-09-21" version="1">MNTEQKKKSLLNHPLLQLLKHNKGNPRTLILMEPLWGIPYNLITPFATLYMYSQGVTDVQIGLILSIAMVVQVLFSFFGGILTDKLGRKFTTMMGDFFGWSVACLIWSISNNFWLFLIAMLFNCFEQINQTAWYCLLIEDAEPKDLLGIYTWVNIGGLIAIFFAPISGLLINSFTVIPVIRVLYLVFSVNMLIKVAVTFRYCKETRQGKIRMAETKNTSLLHMLFEYKELIPKVLKDKEVMKVLAVSVILYITNMVSTNFFSLYVTQWLGIESRYLAFFPILNAAVMLIFMIGIQHKLELVKFRIPMWVGLALYAIAVILLILAPVGNMLFVIIYVFIVAVAGALVMPRKDTLIQLSINAEERARINALIMSFTIAFSSPFGYFAGWLSSIDRRLPFVFAFALFLAAFIIVGRIRDPEFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K424</accession>
    <name>F7K424_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Basal-body rod modification protein FlgD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_00615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for flagellar hook formation. May act as a scaffolding protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the FlgD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00615"/>
    <dbReference type="EnsemblBacteria" id="EGN44803">
        <property type="protein sequence ID" value="EGN44803"/>
        <property type="gene ID" value="HMPREF0994_00615"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047535_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN44803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="208" mass="21853" checksum="4CA534F955CABD86" modified="2011-09-21" version="1">MPGVQLRTNESQDLSSNWSSPKASAGNMGLSIDDFYKILAAQLRYQDADNPMDTSEMMSQMVQTQMIATINQMNQISVITYASSMIGKEVTVALLDKDGWPTGEFKTGVVSGASIYDYPPVLYVDGSGYQVSQVTILGNRNSAQAPQDPDDPNDGDDDGSNPGVEGPGDNDGAPPVDGGEDGNGTPPVDGGEDENSNPPTGNEGNSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K439</accession>
    <name>F7K439_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250579.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00630"/>
    <dbReference type="EnsemblBacteria" id="EGN44818">
        <property type="protein sequence ID" value="EGN44818"/>
        <property type="gene ID" value="HMPREF0994_00630"/>
    </dbReference>
    <dbReference type="GeneID" id="29726837"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854670_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="325" mass="36722" checksum="6E5A83231CAE0CC9" modified="2011-09-21" version="1">MSVKGKKHLSMMFALCKTIAESAEHLNEYSEDHFLKQDTVTGLNTLEASLESFKAYSAIQATRLFRSCVENDLYLYSGDFASIVSHWHTSVLRTIQMLWTAESQRCPVCDKPGNPFYTAYFYRNTGGSDGSASVSRLWMQCPGCLNCYAVKNSPYPFPVPADADTGSNRYIRIAEVVKEHMKGGFLLFAGENNNAFTSALDDNNYIIQRCSLKQLEDRSFSEELQGCFQAVLIEHPGRSADLKKLLENALYYLDDSGILWFEVRNLGVDLLKLVMKGTPLPESADTNVFLFPQGIEYLKDILGFDIISRRRIEEEGTIEFVLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4L2</accession>
    <name>F7K4L2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C_GCAxxG_C_C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00791"/>
    <dbReference type="EnsemblBacteria" id="EGN43500">
        <property type="protein sequence ID" value="EGN43500"/>
        <property type="gene ID" value="HMPREF0994_00791"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.860"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091283_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="154" mass="16915" checksum="93ED2BC66097F111" modified="2011-09-21" version="1">MKSRIQDAVNMFESGFNCAQSVFVTYADIFGMDRQTALKLAGPMGAGVGRMREVCGTVSAMAMLSGLKMGNTDPADEEAKTRSYEMVRKMSDAFRERRGSIICRELLGMSSGMQREESAKPSARTAEYYASRPCSHLVAEAAGIVEEMILEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7K512</accession>
    <name>F7K512_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">HMPREF0994_00948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250897.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00948"/>
    <dbReference type="MEROPS" id="T05.002"/>
    <dbReference type="EnsemblBacteria" id="EGN43257">
        <property type="protein sequence ID" value="EGN43257"/>
        <property type="gene ID" value="HMPREF0994_00948"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1036"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023375694" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023375695" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="190"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN43257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="407" mass="43213" checksum="A5D055882F2883FF" modified="2011-09-21" version="1">MERIKGGVTAAKGFRAAGVEANVKYKNRKDMAMIVSGVPCRAAGVFTSNVVKAAPVVWDREMIDNSPYIQAVVVNSGIANACTGRQGYAYCQETAQTAAAALHIPENTVLVASTGVIGMQLPMDKITAGVEKLAVSLSDSPEAGTLAAEAIMTTDTISKQVAVQFEAGGKTVTVGGMSKGSGMIHPNMCTMLGFVTTDIAISKELLQEALREDVVDTFNMISVDGDTSTNDTLVVLANGCAENPEITEKNEDYENFVKALHEVNETLAKMMAGDGEGATALFETRVIHAATKEDARTLAKSVICSSLTKAAIFGHDANWGRILCALGYSGAKFDPEAVELYFESEAGRILIYKDGQAADYSEEEATKILSCPAVTVVADMKMGEAQATAWGCDLTYDYVKINADYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5K1</accession>
    <name>F7K5K1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_01130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01130"/>
    <dbReference type="EnsemblBacteria" id="EGN42892">
        <property type="protein sequence ID" value="EGN42892"/>
        <property type="gene ID" value="HMPREF0994_01130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1240"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_3_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="419"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="625"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="744"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="1180" mass="132660" checksum="C4CE79EAC68F9143" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5V1</accession>
    <name>F7K5V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01230"/>
    <dbReference type="EnsemblBacteria" id="EGN42477">
        <property type="protein sequence ID" value="EGN42477"/>
        <property type="gene ID" value="HMPREF0994_01230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1343"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="195"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="337"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="599" mass="69327" checksum="05B9A4C574B0A493" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K655</accession>
    <name>F7K655_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42196.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01334"/>
    <dbReference type="EnsemblBacteria" id="EGN42196">
        <property type="protein sequence ID" value="EGN42196"/>
        <property type="gene ID" value="HMPREF0994_01334"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC8C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833632_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42196.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="333" mass="38223" checksum="94D9768B9D37B7ED" modified="2013-09-18" version="2">MLLKKCISDDYDLKKLIKIVFKYFCVFVSGIILYLLNVKVFSMIKGLELTSYQGFNKLGEIWGAGILKGVLKGYLSFFSLIYSDNCGLSNSIIIRAIIAFCFVISILGSIYCIVKLMRDRMKQIICFLILLCFPLGVNVIYAICVTDNSNIYTIMLYPLVLVFIFPVFITELIMNKKRNVWSKKLLNLLSILLLVAGVYYCFLSNEAYLKLHFLQEQTTSYFTTLITQIKSCPGYGDELPIAFVGDKIEDLTLTEMAGFDNVQIAVAEWNLSEWINSYTFLQYMRYHNGFSPKLISQNEFEFSEKINQMPVYPDYGSIQVLDDVVIIKLTKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6D8</accession>
    <name>F7K6D8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251392.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01443"/>
    <dbReference type="EnsemblBacteria" id="EGN41917">
        <property type="protein sequence ID" value="EGN41917"/>
        <property type="gene ID" value="HMPREF0994_01443"/>
    </dbReference>
    <dbReference type="GeneID" id="29725551"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1572"/>
    <dbReference type="eggNOG" id="COG3274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061343_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="9"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="373" mass="41484" checksum="A6943BF8409C7580" modified="2011-09-21" version="1">MAAGKRRLANFELLRMLAMLMVVTMHFLSHTGSLPEAGNGLTERTVASILIEAFCIVAVNVYVFISGYFLSESGFSLKRLIRLICQVLFYTLLIPVVLAAAGVLDPAQVNIYYIWQSLFPVESGHYWFVTAYVIMYLFSPVLNAAVKGMGKKQLQITLVCLFLFFSLGKSLSILMFASDKFGYDFGWFVFLYLTAAYVRKYGIPCLNKKHIGIAVYISSCAAVAVITIITLLICGKTGSLEYYVSVPFHYNFVFCLTGALGLFMAFSGLKIHSEKLASLICRLSPAMLGVYLIHEHMDISASWTGWLIGTPSEHLGGFLIQLAESVLFIFFFGTAVDLLRGKCFMVLERMLARTSVGKKCASAVRHVDEIMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6I7</accession>
    <name>F7K6I7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">HMPREF0994_01495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN41969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251444.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01495"/>
    <dbReference type="EnsemblBacteria" id="EGN41969">
        <property type="protein sequence ID" value="EGN41969"/>
        <property type="gene ID" value="HMPREF0994_01495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1631"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="331" mass="35648" checksum="940D748E9781774A" modified="2011-09-21" version="1">MQYTDIGIDLGTASILVYIRGKGVVLKEPSVVAFDRDTNKIKAIGEDARLMLGRTPGNIVAVRPLRQGVISDYTVTEKMLKHFIQKALGRKTFRKPRIAVCVPSGVTEVEKKAVEDATYQAGAREVSIIEEPIAAAIGAGIDISRPCGNMIVDIGGGTSDIAVISLGGTVVSASIKIAGDDFDEALVRYMRKKHNLLIGERTAEDIKIKIGSAYKRPEPDYMDVRGRNLVTGLPKTVKVSSEETEEALREPTLQIVEAIHSVLERTPPELAADIADRGIVLTGGGSLLRGLEELISDKTGINTMTAEDPMTAVAIGTGKYVEFLVGYKDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6M3</accession>
    <name>F7K6M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01533"/>
    <dbReference type="EnsemblBacteria" id="EGN42007">
        <property type="protein sequence ID" value="EGN42007"/>
        <property type="gene ID" value="HMPREF0994_01533"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1672"/>
    <dbReference type="eggNOG" id="ENOG5033BRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111138_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046313">
        <property type="entry name" value="DUF6465"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20069">
        <property type="entry name" value="DUF6465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="192" mass="20686" checksum="DB31EB291EBDE7D0" modified="2011-09-21" version="1">MAEMKKTAAKETAEPVEKITAKADALKIDTKEPEKTPAVKTAVKEPAEKKAPAKKAPVKKETVKKETVKKETVKKEPVKKEAVKKAPVKKTAAKPAAEKTTAEKPASAAKPAAKKAPAKTAAAKAEAKEIVTVQFAGKSYSTEDLVKIAKDVWKYDLGKNEADFKDVELYVKPEESSVYYVINGDVTGSFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6X2</accession>
    <name>F7K6X2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_01639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251552.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01639"/>
    <dbReference type="EnsemblBacteria" id="EGN42113">
        <property type="protein sequence ID" value="EGN42113"/>
        <property type="gene ID" value="HMPREF0994_01639"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1790"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="297"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="535"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="674"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="796" mass="89668" checksum="8B4708ADA8AA63AA" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K743</accession>
    <name>F7K743_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_01672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251585.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01672"/>
    <dbReference type="EnsemblBacteria" id="EGN41710">
        <property type="protein sequence ID" value="EGN41710"/>
        <property type="gene ID" value="HMPREF0994_01672"/>
    </dbReference>
    <dbReference type="GeneID" id="29725253"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_5_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN41710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="259" mass="29168" checksum="FC6118330176235D" modified="2011-09-21" version="1">MADNSSVQSVERTFDIIENLSSAPLGLTLLELSSDVGLPKSTVHRLLSTLTGRGYITQDPESKKYLLTLKLFEISSRSLAGFDILTAARPYLQHLSRITNEAVHLVVREGHEVVYIYKEDSSKNTVRMASHIGLHNPMYCTGVGKAIMAYLPRSEQEQIWKATEIIPYTDKTITDYELMLKELDHIKECGYAIDDEEHENDVCCAACPIFDYTNMPYAAISISAPRSRMDNDRMEHRIIPELLTATRRISGIMGCPEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K762</accession>
    <name>F7K762_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_01691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000007">
        <property type="protein sequence ID" value="EGN41729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251604.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01691"/>
    <dbReference type="EnsemblBacteria" id="EGN41729">
        <property type="protein sequence ID" value="EGN41729"/>
        <property type="gene ID" value="HMPREF0994_01691"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1846"/>
    <dbReference type="eggNOG" id="COG2720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011572_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356449" description="G5 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="374"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN41729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="529" mass="56652" checksum="54AA71CE0FCADF13" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7N1</accession>
    <name>F7K7N1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIID/LytB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01925"/>
    <dbReference type="EnsemblBacteria" id="EGN41330">
        <property type="protein sequence ID" value="EGN41330"/>
        <property type="gene ID" value="HMPREF0994_01925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2112"/>
    <dbReference type="eggNOG" id="COG2385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021203_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoIID" evidence="1">
        <location>
            <begin position="82"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="335" mass="36997" checksum="3ECB5EF07322281C" modified="2011-09-21" version="1">MDRNSLLPKARPASRRPLQGAFRSTAGRQRLLDLCAVLLFLLLLPYACSLLFGKGDVGEETLAVPRDESSIMVACDTGIGMSRLPLETYVEGALAASIPADCEEETLKAQAIILRTLCMRAYENRQSIDDNTVYARDIGQEYLDMRSREALWEDSYEEKQAKIASAAAQTKGMYMTWEGQIIEPAYFWLSAGKTRNGKEVFGEGYDYLTSVDCSHDIEASGYSSTVTLKEKDFWAAMGVDGSEKITLTRDSAGYVLWVEAAGIHMSGEKFRSLFSLQSACFTISENGGNVTLESKGVGHGLGFCQFEANRRAVQGEDFLALLHVFFEGVEIQKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K7Q0</accession>
    <name>F7K7Q0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251857.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01944"/>
    <dbReference type="EnsemblBacteria" id="EGN41349">
        <property type="protein sequence ID" value="EGN41349"/>
        <property type="gene ID" value="HMPREF0994_01944"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2136"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="191" mass="22026" checksum="D27AE5DD827AFFA8" modified="2011-09-21" version="1">MFIRYKNLTIRNAVSADAEQLCAWWNDGKVMAHAGFPNGVGCTPEEIRESLASDRDESHRRHIIELDGTPIGEMNYRNKEGAAELGIKICDFTRQEKGYGTELLTVFIDALFCYYGYEKMILDTNLKNERAQHVYEKKLGFRRVGIETDAWQDQLGEWNSIVNYEMSKADWLASRRELPDYICNIPESVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K864</accession>
    <name>F7K864_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41518.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02113"/>
    <dbReference type="EnsemblBacteria" id="EGN41518">
        <property type="protein sequence ID" value="EGN41518"/>
        <property type="gene ID" value="HMPREF0994_02113"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010964_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41518.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="797" mass="89167" checksum="FB0DBB9141F81BCF" modified="2013-09-18" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8A2</accession>
    <name>F7K8A2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251788.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01875"/>
    <dbReference type="EnsemblBacteria" id="EGN41280">
        <property type="protein sequence ID" value="EGN41280"/>
        <property type="gene ID" value="HMPREF0994_01875"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2055"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_2_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012738">
        <property type="entry name" value="Tscrpt_reg_DhaS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02366">
        <property type="entry name" value="DHAK_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN41280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="195" mass="22396" checksum="077B0838BB21D0D4" modified="2011-09-21" version="1">MSDSLITKKAIAQCLKNLAAEKSFLKISIGDITAACGLNRQTFYYHFQDKYELLDWIYYEECFVPILDGITFDNWHLRIKQLLDTLKKEKVFYSNVIKNAGEGFSNYLYSITSTLFEEAAAVLDEEGLVNGEEKKFIGSFYAYGICGVVMQWVTDGMKEQTDEVAQRLRRLARSTELLASRRFADMKNESSEPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8B2</accession>
    <name>F7K8B2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN41290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251798.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01885"/>
    <dbReference type="EnsemblBacteria" id="EGN41290">
        <property type="protein sequence ID" value="EGN41290"/>
        <property type="gene ID" value="HMPREF0994_01885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2066"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="76"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="309" mass="35100" checksum="096C41A7FB1FE915" modified="2011-09-21" version="1">MEELKLIPPLQIPPESFPESEELPEGVKTVKWKDTFGYDVEFLPDEVYANRDGINLHLKVLIPRTMEEPDRQWPLIVFVQGSAWHRQDLYCHLPALLRMSQRGYAIAIVEYRPSDIAPFPAQVQDTKTAIRFLRINASRYRIDPQHVALWGDSSGGHTALMTGFTGDDAPDMDAYREQSAAVNCIVDWYGPTDIAKMNYYPSVQDHIGPESPEGFVIGRKNVLENPELADATVPMNYLSREKETPPLLIMHGGSDMLVPFNQSCRLYHKMKELGKVVEFVKLVGANHGFGGFNCEEALDMVEEFIKRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K8L0</accession>
    <name>F7K8L0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_02198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN41105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002593315.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02198"/>
    <dbReference type="EnsemblBacteria" id="EGN41105">
        <property type="protein sequence ID" value="EGN41105"/>
        <property type="gene ID" value="HMPREF0994_02198"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2403"/>
    <dbReference type="eggNOG" id="ENOG50330ZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164777_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024215">
        <property type="entry name" value="DUF3847"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12958">
        <property type="entry name" value="DUF3847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN41105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="68" mass="8182" checksum="4E16952FB9D907B7" modified="2011-09-21" version="1">MTENEKKLLQAKHRLEEAEMRDRQKERKARTRRLVQEGAILEKALPQTTQMTLEQLEDFLCEVFKPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K932</accession>
    <name>F7K932_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_02370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252271.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02370"/>
    <dbReference type="EnsemblBacteria" id="EGN40769">
        <property type="protein sequence ID" value="EGN40769"/>
        <property type="gene ID" value="HMPREF0994_02370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2593"/>
    <dbReference type="eggNOG" id="COG1453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN40769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="341" mass="38258" checksum="C45D5E16F0EE448B" modified="2011-09-21" version="1">MEQVTLGKTGICVNKNGFGALPIQRISDEEAVLLLRKACDNGITFFDTARAYTDSEHKLGLAFHDRWDDTIYVSSKTAAGTPEGFWKDLETSLAQLQRDYLDLYQFHNPAFCPKPGDGSGLYECMLEAKKQGKIRHIGITNHRLAVAEEAVESGLYETLQFPFSYLSSDKDLELVDKCEKAKMGFIAMKALSGGLINNSAAAYAYLSQFPHVLPIWGVQREKELDEFISYVQNPPALTQELKNVITDDRQELQGEFCRGCGYCMPCPAGIEINNCARMSLLIRRSPSEAQLTSEMQEKMMQIEKCLHCGKCKSKCPYNLDTPALLERNLKDYKEILAGKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7K967</accession>
    <name>F7K967_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA_MISMATCH_REPAIR_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_02410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252311.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02410"/>
    <dbReference type="EnsemblBacteria" id="EGN40809">
        <property type="protein sequence ID" value="EGN40809"/>
        <property type="gene ID" value="HMPREF0994_02410"/>
    </dbReference>
    <dbReference type="GeneID" id="29726122"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2640"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030717_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="405"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN40809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="605" mass="68731" checksum="5568683B9F73BF50" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9M2</accession>
    <name>F7K9M2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_02445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252346.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02445"/>
    <dbReference type="EnsemblBacteria" id="EGN40844">
        <property type="protein sequence ID" value="EGN40844"/>
        <property type="gene ID" value="HMPREF0994_02445"/>
    </dbReference>
    <dbReference type="GeneID" id="29725565"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2679"/>
    <dbReference type="eggNOG" id="ENOG503260U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154854_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356748" description="PG_binding_1 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="159"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN40844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="213" mass="22412" checksum="35B7FF7F53DC07F5" modified="2011-09-21" version="1">MNKKIFLTCLAAGILVFLLPAREVKAAENQTTEDYYYQLLINGEYPYNTAANAGTGVTVPAGGWEQMVAMANQQLTQAVARQQSLEAARQNLDVQLQAASQAVVQAQAALTAAQQAYASALQAAAYSQQAALLNQQAALSNQGTAGVPLTAPALTADTILQVQNLLNFYGSSCSPTGVYDAQTQAALFQFQTKYGLAADGTINAQVLQLFGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9P8</accession>
    <name>F7K9P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_02584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252485.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02584"/>
    <dbReference type="EnsemblBacteria" id="EGN40983">
        <property type="protein sequence ID" value="EGN40983"/>
        <property type="gene ID" value="HMPREF0994_02584"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2831"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356749" evidence="2">
        <location>
            <begin position="28"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="461" mass="50599" checksum="48E92AEC4E6D3FE9" modified="2011-09-21" version="1">MKRKSVSIGLAALLAVSLLAGCGGKGAAETGSTGDTKAVQEADNTGNAETTGGGTGEQVTINFQTWNPGEGAAIDEVIAAFEEKYPNIKVNHVYMPYTDHVEKLKIDLASGEGADVFGMQTGATIKEFRDFEMDLTSYAEESWGSSWKDQYMDFCMDLLNEDGHYYGLPLGLTYAGFTWADVNMLKEYGLEVPTSYDDLKECAKVLRENGQYPLTIGAKDAWINIDTWMSMANDINPEKLYSAIEGETPFTDPDLVESFRIWQSCFTEGIFQDGALGVGVYNDTSDLFEKEGSIPMIQNGSWSAGFYVSGDPDQNRVFNSEGADHDIFLIDWNNDGKVCPVTASVDVCLCMNKNTKNPEAAWTFIDFMLHEGQDILINRYFSYCPSRKDLELNVEGMNQDGLDNLAYIVEQSENNLGGYREMAYADLKQVISDQLTVLALGDATPEEAAAAIEAASQAQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K9Q2</accession>
    <name>F7K9Q2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_02352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02352"/>
    <dbReference type="EnsemblBacteria" id="EGN40751">
        <property type="protein sequence ID" value="EGN40751"/>
        <property type="gene ID" value="HMPREF0994_02352"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.2573"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="36"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN40751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="258" mass="28721" checksum="F093EE41848EA71B" modified="2011-09-21" version="1">MLYYSFTDWRGTSGSQHFVGWANYVHVFTNETYRNVFKTAGYYLAAGVLQQIISLALAVLLSKPVKGNSIFKGIIFFPFIMNGVAVALTYRIFYQPDGAFDVLLNALGSGGLVRIWLSNPGTVNWALGYVFLWKNVGYSFLIYLGTMQSISKEYYDAAAIDGAGTWRQFTAITFPNMKMIIGLMATFSIVNSIAVFDIPYILTSGKNGTNTFSTTMLETAFTYNKFGEACAMAIVMLLIAGLVMILRNCAFREEKDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAA7</accession>
    <name>F7KAA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="8">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">leuS</name>
        <name evidence="14" type="ORF">HMPREF0994_02957</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252858.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02957"/>
    <dbReference type="EnsemblBacteria" id="EGN40566">
        <property type="protein sequence ID" value="EGN40566"/>
        <property type="gene ID" value="HMPREF0994_02957"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3227"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="39"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="221"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="417"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="650"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="581"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGN40566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="807" mass="91357" checksum="06F33B6760B15AF5" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAL7</accession>
    <name>F7KAL7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">HMPREF0994_02843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN40452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009252744.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_02843"/>
    <dbReference type="EnsemblBacteria" id="EGN40452">
        <property type="protein sequence ID" value="EGN40452"/>
        <property type="gene ID" value="HMPREF0994_02843"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3111"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="149" mass="16638" checksum="44889B281F8E327F" modified="2011-09-21" version="1">MKFVIQRVSHASVTVEQEIVGSIQKGFLVLIGVNNTDTEGIADKMLRKLLNLRIFEDENGKTNMSLKDVNGSLLLVSQFTLYADCKKGNRPSFVKAGSPEHAEQLYEYIKHACKKEGYPVECGIFGAHMKIELENDGPFTIVLDSDELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KAZ4</accession>
    <name>F7KAZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03023"/>
    <dbReference type="EnsemblBacteria" id="EGN40200">
        <property type="protein sequence ID" value="EGN40200"/>
        <property type="gene ID" value="HMPREF0994_03023"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZZHB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096420_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="29196" checksum="68E3253704F7896F" modified="2011-09-21" version="1">MRINKEKRIGQVLFIVEGSSTEFNYLYKIFCGLLGYSYVAKKRNTPDYYVKDSDPYSKVAVVNTRESNIRDISENPKYLDDVFDVLREQYHFPVERSAIYYLFDRDPESNTNIELIEKYIKILANPYDNEDGEQAGQLLLSYPSIESFIVSNFIDETINLYFGLGKEVKNYIGKNKQIQLNKISDKTLIKAAYEFMSYLTAEEITWDIDDFAPASFAVFTKQEANYLLGGGFRLFSMLTLALFQMGILELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBD4</accession>
    <name>F7KBD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_03166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253067.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03166"/>
    <dbReference type="EnsemblBacteria" id="EGN39996">
        <property type="protein sequence ID" value="EGN39996"/>
        <property type="gene ID" value="HMPREF0994_03166"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3459"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045984_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356782" evidence="1">
        <location>
            <begin position="38"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048" evidence="2">
        <location>
            <begin position="55"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="3">
        <location>
            <begin position="246"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN39996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="365" mass="40160" checksum="2A1A20429950D5EF" modified="2011-09-21" version="1">MKWKSVFPHVQKNKKKKWKALSAVLAAVLCMTAAAPAAELHAEEGPAGYVRSVYTNEWVPAAQAASRPIAIMMPTDKAAQPSYGISHAKVLYEIMEEGDISRQLAVIDDWQGLSRIGNIRSCRAYYIPIATEWDPILVHYGGVWYMADRISMPDINNLSGTFEYGTGGSAPGANAFFRSSDRKAPHNAYISGSGITNACSQLGYSLALRPEFYSPKHFNFSAGVNTLAQYGAGAQTANQINLSNVFPYTKTGFTYNAADGLYYKTIHGKAHKDAANGQQLAFANVIVQNTKWMTLDAKGYLAFYNFDTTEDGYYFTKGKCIHITWQKTTDYGPTRYFDDAGNEIQLNEGKTYIAVAQKGRAAAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBE6</accession>
    <name>F7KBE6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03180"/>
    <dbReference type="EnsemblBacteria" id="EGN40010">
        <property type="protein sequence ID" value="EGN40010"/>
        <property type="gene ID" value="HMPREF0994_03180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="234" mass="26524" checksum="89520DDC1EC51F85" modified="2011-09-21" version="1">MKKLIIFDAYGTLIAAGAGYREAVRRIPELTECGVNPELFCEEWKILHRQHKEEANGNGYLTEAEIFRKDLSVLYSRYGITGNRNKDADFMQTALGVSKAFEGAADAVNQLKKKYRVIIGADSDTEPLLLNIRRNGMEPDGIYSSEDLKIYKPDRRFYQKMLCSCGCEAENTIYIGNSYHEDVEGPASAGIPSILIDRRRTHTQDRKHTIQPLAVVHSLYNLVQLLEKMPPNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBI6</accession>
    <name>F7KBI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_03222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253123.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03222"/>
    <dbReference type="EnsemblBacteria" id="EGN40052">
        <property type="protein sequence ID" value="EGN40052"/>
        <property type="gene ID" value="HMPREF0994_03222"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3521"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_6_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN40052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="387" mass="45029" checksum="F9E3ABFF8F57B58B" modified="2011-09-21" version="1">MLEEHVMLQFLRKFDEYPFLVKMDGKEYLIGEGDPTFNVQFNKEIPLSDLATSTSLALGEAYMNHDLEVEGDLYNALDHFLGQMGKFSADHNALKKLIHTSTAKKNQQKEVSSHYDIGNDFYKLWLDETLSYSCGYFLHEDDTLYQAQVNKVDYILQKLCLKEGMTLLDIGCGWGFLLIEAAKKYKIKGTGITLSQEQYKECQARIKEEGLEDYLTVELMDYRDLPKSHLTFDRVVSVGMVEHVGRENYQTFLHCVSQIMKPGGLFLLHFISALKEYPGDPWIKKYIFPGGMVPSLREMISGMAEEQFHTMDVENLRLHYNRTLLCWRKNYLEHLDTVRSMFDEKFVRMWHLYLAACAATFHNGIIDLHQILMTKGINNELPMVRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBQ9</accession>
    <name>F7KBQ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PNP_UDP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253198.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03297"/>
    <dbReference type="EnsemblBacteria" id="EGN40127">
        <property type="protein sequence ID" value="EGN40127"/>
        <property type="gene ID" value="HMPREF0994_03297"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3605"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN40127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="264" mass="29353" checksum="66F21B55C651E938" modified="2011-09-21" version="1">MLDKKEFPILEYDSSPKAKIEPLNTVSKIDGPECCVITFFGDVIENMLKANRLKQIAVFSSCTVKLPVYETEYLGKKIALTQGFLGAAGSAAQLEELIAMGFSKFIVCGAAGVLQKGIQVGHLVIPGSAVRDEGVSYHYIEPSREIECNPYVVSIMENYMKRNKIPYINAKTWTTEAFYRETDAKIDLRVSEGCVTVEMEAAAFFAVSKFRNVLLGQILFCGDDLSGIEWDSRSWCSREGIRKNLVDIALEICLELHAAAIQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBT3</accession>
    <name>F7KBT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253231.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03330"/>
    <dbReference type="EnsemblBacteria" id="EGN40160">
        <property type="protein sequence ID" value="EGN40160"/>
        <property type="gene ID" value="HMPREF0994_03330"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030XHG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129792_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046286">
        <property type="entry name" value="DUF6323"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19848">
        <property type="entry name" value="DUF6323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="179" mass="21223" checksum="409B683F9620B6F9" modified="2011-09-21" version="1">MEDNFFEMILAEKEKKEMTVLMACNEKTETFGLSLTEQEAKELVVCRNESLKKYRRVEFGNGILDKLIFTFCDSQYINQENYKETMEKLQDIFYCFKNEAEDQLTDDELLSFMREQFEEICMGDTEYLESTCLPRFAAAIRAGYRGYQESGGNGEYENLSQEARWDKDLYMDVVKELFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KBT8</accession>
    <name>F7KBT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN40165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253236.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03335"/>
    <dbReference type="EnsemblBacteria" id="EGN40165">
        <property type="protein sequence ID" value="EGN40165"/>
        <property type="gene ID" value="HMPREF0994_03335"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195853_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN40165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="72" mass="8389" checksum="ACF60F1894A3EA1A" modified="2011-09-21" version="1">MRRITSACLLQTMRFDNLNGENPEQELEIYCKKLDMKKAAYAIEEKTVQPGGALVVKIKRQYNQYKTDGYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC23</accession>
    <name>F7KC23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253303.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN39909">
        <property type="protein sequence ID" value="EGN39909"/>
        <property type="gene ID" value="HMPREF0994_03402"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZVG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138399_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN39909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="140" mass="16005" checksum="9DFADFD7E75E8CC1" modified="2011-09-21" version="1">MKKSTQELFDLMKKTQAFDTYMEITKEERVETTVSAALEKLLEEKNINKSKCIEASGLDRTYAYQIFSGIKTPSRDKLLALCLGMGLTLEETQTLLKQTGYPPLYPRTERDCAIIHALYQNLTIVNLNELLYEMGLEIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KC70</accession>
    <name>F7KC70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1_PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253350.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03449"/>
    <dbReference type="EnsemblBacteria" id="EGN39522">
        <property type="protein sequence ID" value="EGN39522"/>
        <property type="gene ID" value="HMPREF0994_03449"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.3768"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_5_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN39522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="212" mass="22933" checksum="1F149B5317F0ABD9" modified="2011-09-21" version="1">MFTMYVYVLDTLADWEPGYVISELNSGRFFKKDGQRVSVKTVSCSKDPITTMGGMTIVPNCLVDEMVVNETSILLLPGADTWNDPKHGAVIEKAGEFLSSGALVCAICGATAALANIGLLDNRPHTSNGPGFLEMVSPGYKGQSFYIDKPSVADNNLITAGSTGALLWAKQIIEHLDVFRSDTLEAWYKYFSTGDPNAFFALMQTLPSGSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCI8</accession>
    <name>F7KCI8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN39481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253473.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03572"/>
    <dbReference type="EnsemblBacteria" id="EGN39481">
        <property type="protein sequence ID" value="EGN39481"/>
        <property type="gene ID" value="HMPREF0994_03572"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN39481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="330" mass="37169" checksum="3D27B2970E38AA61" modified="2011-09-21" version="1">MATIKDIAKLCGVSEGTVDRAINDRAGINPETKKRIMEIVEQVNYKPDRIAQSLAKGRTRTLGLIFFDLNNDFIAALVDTIETIAKEKGYFISLVLTHGIKEEEIKGINYLLERKVDGIIVFPVGNQADYQELKINIPVISIYNKISDQFPYVGVDAQSAMRDAADYITRCQYERIILVNSSITKKIKGGINVFTLQERQKGYIEGIEKNNINEGEGPLIVEGLDFSRMDTLYRQGQGKRTAFLCICDVFALEVLTHFREQSLKVPEDVGIMGFDNMSIRKYVSPQLTTVGYHMSEMAQKIFAYLMEMIHGSDVPKDISFPCQIIEGNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KCV1</accession>
    <name>F7KCV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PFL2/glycerol dehydratase family glycyl radical enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_03680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN38961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253581.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03680"/>
    <dbReference type="EnsemblBacteria" id="EGN38961">
        <property type="protein sequence ID" value="EGN38961"/>
        <property type="gene ID" value="HMPREF0994_03680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4015"/>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009096_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010098">
        <property type="entry name" value="PFL2/GDeHydtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01774">
        <property type="entry name" value="PFL2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="8"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="671"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN38961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="791" mass="90084" checksum="C63A1275F2ADF84B" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD42</accession>
    <name>F7KD42_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253672.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03771"/>
    <dbReference type="EnsemblBacteria" id="EGN38742">
        <property type="protein sequence ID" value="EGN38742"/>
        <property type="gene ID" value="HMPREF0994_03771"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4114"/>
    <dbReference type="eggNOG" id="ENOG502Z8QN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075559_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025051">
        <property type="entry name" value="DUF3990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13151">
        <property type="entry name" value="DUF3990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="149" mass="17423" checksum="558ADDB0308854C9" modified="2011-09-21" version="1">MEIVRPDLKHSRPNVDFGLGFYTTPIYDQAVKWCGKFMRRGKNGIVSRYEFNETAYDDLKVLKFNSYSEEWLDFILTCRSGKDTSDYDIVMGGVANDKVFNTVELYFDGLIDKSEAINRLRYEKPNMQICLRTENAIENYLHFEGSEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KD45</accession>
    <name>F7KD45_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253675.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03774"/>
    <dbReference type="EnsemblBacteria" id="EGN38745">
        <property type="protein sequence ID" value="EGN38745"/>
        <property type="gene ID" value="HMPREF0994_03774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004178_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="45"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="288" mass="33062" checksum="5932C6134A8167ED" modified="2011-09-21" version="1">MEWNHIQIPNGDTNLFCNCYVTGKSAMNIIVTHTPICTTLDVQSAYAPLTKYGVNIFAFDFSGTGKSGGDEKKFSVHSIVSDLDKLVDYIEEHYSSNIHLFGDTGIGGMFAQCYICSTDRIKSFAQFACVDYKNTAGMGYPYFAVKMMSWLFSRLPNFHLTIKPPKYNGYNCEQDNGFYEMLIKRNPYIFKSSTKVMNAVFECLISPDSPIQNSITIPTLVFKTLHDRYFSKEYFDSYFSSLNCKKKLIEINDVHNSYYLRCDEFCEAAYNWFSENQEITVSKHRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDA6</accession>
    <name>F7KDA6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253736.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03835"/>
    <dbReference type="EnsemblBacteria" id="EGN38600">
        <property type="protein sequence ID" value="EGN38600"/>
        <property type="gene ID" value="HMPREF0994_03835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020575_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="677" mass="78308" checksum="614C81C771E0EF78" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDD2</accession>
    <name>F7KDD2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_03865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253766.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03865"/>
    <dbReference type="EnsemblBacteria" id="EGN38630">
        <property type="protein sequence ID" value="EGN38630"/>
        <property type="gene ID" value="HMPREF0994_03865"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_9_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN38630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="420" mass="46091" checksum="E8207E3594627C6A" modified="2011-09-21" version="1">MNEQKKLFYGWYILAVSVLVMALCYAPVVSCASLFVTPITEEFGFARSAFTITKTIASLVGMAVAPFFGKIMAKKHMHAVWVGSLLGVTAVFTGMSFASTLPQFYIISFIQGLFTTSAAMLPVNIVLTNWFRKKRGFIVSIAMAGSGIGGTVLSRLMGTMIVEHGWRYTYRFLALLILCILVPAVGLVIRRTPVEKGLKPYGEEMDDTLKTERERQNAGKRMEKEWNASLKELRSLPVFWAYVFGIALIAFTSAVIIHIPSAVVDAGYTMEKAASISSLYLLIAVPGKMILGYIFDRLGVRAGILFGGAVFLLSMLSLLVIQQPPVLFLMAVFFGFGACLSTVSPSIIASRTFGTKNYPEIFGVTTMLVNGGYAIGVPVIGLFYDMTGSYYPAWIVMGILAVLMTVSLLYSYQKSREYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDE7</accession>
    <name>F7KDE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_03880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03880"/>
    <dbReference type="EnsemblBacteria" id="EGN38645">
        <property type="protein sequence ID" value="EGN38645"/>
        <property type="gene ID" value="HMPREF0994_03880"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140880_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN38645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="138" mass="15515" checksum="C88205E29DE91793" modified="2011-09-21" version="1">MDEMNIKECEAAVEAVRKCESEEELGTLLWNVVELNAGSTFYTSKKLPFTYRVKGRELFCDRKEKSITQATVLRAYKKIREAREAGEPIRGPKKLSMFGAPYIWGILKGTGLAGEEAETEKKEESEAAEMPEKSGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDF7</accession>
    <name>F7KDF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">HMPREF0994_03890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253791.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03890"/>
    <dbReference type="EnsemblBacteria" id="EGN38655">
        <property type="protein sequence ID" value="EGN38655"/>
        <property type="gene ID" value="HMPREF0994_03890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4233"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084630_2_0_9"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGN38655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="181" mass="19194" checksum="D6AC950C1333DC79" modified="2011-09-21" version="1">MRIGMGYDVHRLTEGRKLIIGGVDIPYEKGLLGHSDADVLLHAIMDALLGAAALGDIGKHFPDSDPAYKGISSMELLDKVGQLLEDNSFLIENIDATIIAQAPKMRPYIDTMRENIARVLQIEVSQVNVKATTEEGLGFTGTGEGISSQAVCLLNTPYGLYSSDVNAGCAGCGGCPKNGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDI8</accession>
    <name>F7KDI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009253834.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03933"/>
    <dbReference type="EnsemblBacteria" id="EGN38698">
        <property type="protein sequence ID" value="EGN38698"/>
        <property type="gene ID" value="HMPREF0994_03933"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033IKY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192906_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="63" mass="7217" checksum="6F5CA431BEBF721E" modified="2011-09-21" version="1">MSACMDCGKNLTYNEIGAYKKFVNRGSRSFLCKQCLAQKLDVTTEDIDRKIEQFKQQGCTLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F7KDL6</accession>
    <name>F7KDL6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_03961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000018">
        <property type="protein sequence ID" value="EGN38726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_03961"/>
    <dbReference type="EnsemblBacteria" id="EGN38726">
        <property type="protein sequence ID" value="EGN38726"/>
        <property type="gene ID" value="HMPREF0994_03961"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2770601_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN38726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="69" mass="7361" checksum="E289C9E88164DB56" modified="2011-09-21" version="1">MHPSQGLWFPGVMAVAWLLSPARGVWGCGWGSSLKNGVFLNVPFSREAANAAELLALAGFAAQTRQTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE20</accession>
    <name>F7KE20_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254000.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04099"/>
    <dbReference type="EnsemblBacteria" id="EGN36892">
        <property type="protein sequence ID" value="EGN36892"/>
        <property type="gene ID" value="HMPREF0994_04099"/>
    </dbReference>
    <dbReference type="GeneID" id="29729489"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979305_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="45"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="284" mass="33152" checksum="3E6137437C7B4802" modified="2011-09-21" version="1">MGMDYPALLRENQSFRSDYPAEIKYAFSCKEYESLEKEYGIHETAGKGSTFLQAVNLLEWVNKNIRHKGNYDNSDPQDALHLLTLAYKKDNTGINCLSMSIILSECLLASGIYARVVYMIPKAADDGDNHVVAEAFIAEWNKWIMLDPTYGSYCCDSSGEVLNLYEIRKRIINDEEYFFSDKLNYNGETVSDLADLKEYYAKNLFFLRSKARQGYGMHREYGDMVEMAPINFDVHERMLLNLQYRLHEYGECDLFTDWMSYESQLDNRYVDIETFYEPPCDREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE35</accession>
    <name>F7KE35_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254015.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04114"/>
    <dbReference type="EnsemblBacteria" id="EGN36907">
        <property type="protein sequence ID" value="EGN36907"/>
        <property type="gene ID" value="HMPREF0994_04114"/>
    </dbReference>
    <dbReference type="GeneID" id="29729198"/>
    <dbReference type="eggNOG" id="ENOG5031H6P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141419_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="243" mass="28264" checksum="86A6AAE7BF8569C0" modified="2011-09-21" version="1">MIRIGRGGLWNNSYKDEIVFCKKNHFDFIQIWFKDGELLVNDLPSPKEEYIKKAGFPVILHALFEPDDFERYGNQLLDLVSFFGDKEVIVHPVCKKKAVDQRTEYELAEHVLDFSQKAKARGILWYLENNSVLDIFHYKKEDLEIVYKADSYVEQLLDIAHIDNYQHLEDIISVKFPRCLHAAGKHFAVPHEHLPLTCGDIDYKLVFQKYLHGYSGRIILEVDGSGEEMEASKRILDEAVLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE51</accession>
    <name>F7KE51_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254031.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04130"/>
    <dbReference type="EnsemblBacteria" id="EGN36923">
        <property type="protein sequence ID" value="EGN36923"/>
        <property type="gene ID" value="HMPREF0994_04130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4502"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115862_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="137" mass="16039" checksum="D2A119E7A6596350" modified="2011-09-21" version="1">MIYRETEEITKEERKNVFDKLLAYNLSHLEDKNPRELGIFLEDEEGNCQGGLIGMTHGNWLDVEYLVVDEALRGQNMGSELLKRAEQAASDRGCKYVFLDTFSFQAPEFYKKMGYKEVFVREEYPVTGKRHYLVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KE82</accession>
    <name>F7KE82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_04161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04161"/>
    <dbReference type="EnsemblBacteria" id="EGN36954">
        <property type="protein sequence ID" value="EGN36954"/>
        <property type="gene ID" value="HMPREF0994_04161"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4535"/>
    <dbReference type="eggNOG" id="COG3822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1204311_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010864">
        <property type="entry name" value="D-lyxose_isomer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07385">
        <property type="entry name" value="Lyx_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN36954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="27002" checksum="52ABB4662EA15C31" modified="2011-09-21" version="1">MGVLKIMKRSEINAALKEMEAMVKEHRFELPPFCDFTPEEWQNKSHEYDEIRDNMLGWDITDYGLGKFDEVGFSLITIRNGNLKNPKYTKTYAEKLLYIKEGQMAPMHFHWNKMEDIINRGGGNVLIRVYNSTKDEQFADTDVTVNCDGREFTVPAGTQVKLKPGESITIYPYMYHDFELEPGTGPVLLGEVSMCNDDNTDNRFYEPIGRFPEIEEDEPPYRLLCNEYPVAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEA7</accession>
    <name>F7KEA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Antibiotic transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254087.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04186"/>
    <dbReference type="EnsemblBacteria" id="EGN36466">
        <property type="protein sequence ID" value="EGN36466"/>
        <property type="gene ID" value="HMPREF0994_04186"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4567"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN36466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="315" mass="34553" checksum="2069B8BDE60F59B9" modified="2011-09-21" version="1">MNKMIEVKNLKKSYKTGKAVDGVSFDVYKGEILCILGPNGAGKSTTINMLTGALGWDGGGIYADFLKGKSIHDDLPAYKRRLGVVPQDLAIYEDLSARNNVEFFASLYGLRGRALQEGCRFALAFAGLTDRAGDKAGTFSGGMKRRLNIACAIAHRPELLVMDEPTVGIDPQSRNHILESIKRLRDEGMTIIYTTHYMEEVEEISTRIIVMDHGKIIAGGTKEELKERTDTDKMITIEADGLDTFDSDTLYRIEGVKKVSAGAGTLKLAVIPGIENLDRIIAVLIEHGKRINSITTQAISLETVFLNLTGRSLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEF0</accession>
    <name>F7KEF0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_04231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254132.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04231"/>
    <dbReference type="EnsemblBacteria" id="EGN36511">
        <property type="protein sequence ID" value="EGN36511"/>
        <property type="gene ID" value="HMPREF0994_04231"/>
    </dbReference>
    <dbReference type="GeneID" id="29729110"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4619"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN36511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="538" mass="61511" checksum="2FD43FCC3FABB374" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEI8</accession>
    <name>F7KEI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000020">
        <property type="protein sequence ID" value="EGN36554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254175.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04274"/>
    <dbReference type="EnsemblBacteria" id="EGN36554">
        <property type="protein sequence ID" value="EGN36554"/>
        <property type="gene ID" value="HMPREF0994_04274"/>
    </dbReference>
    <dbReference type="GeneID" id="29729327"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4668"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363945" evidence="2">
        <location>
            <begin position="23"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN36554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="566" mass="63382" checksum="471CF57F54C5C7D8" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEY7</accession>
    <name>F7KEY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_04423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254324.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04423"/>
    <dbReference type="EnsemblBacteria" id="EGN35733">
        <property type="protein sequence ID" value="EGN35733"/>
        <property type="gene ID" value="HMPREF0994_04423"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4831"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN35733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="304" mass="34334" checksum="93A54C6020D02035" modified="2011-09-21" version="1">MAGKPKNKKSPAGADRRLFDVLSYVILFVLSFLCALPFLLVISGSFSQQTDILMHGYRLFPEKVSLDAYKMLFKIPEELLRAYGVTIFVTVTGTFFGLWFTSMAAYVIASKDFRYRYQVSFFFYFTSIFGGGLVPWYVFNTKYLHFHNNLIALILPILVNVTYLLILKSYMMNIPDSLYESARLDGAGDFTIYWRIVMPLTKSGLATVGLFIALAYWNDWYNAMLYMDEGSRNLYPLQYFLNNILTKAQAMNAAAARSGIPASDVPSEPMKLAMTVVATGPIVLLYPFLQKFFVKGVTIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7KEZ6</accession>
    <name>F7KEZ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HMPREF0994_04433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254334.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04433"/>
    <dbReference type="EnsemblBacteria" id="EGN35743">
        <property type="protein sequence ID" value="EGN35743"/>
        <property type="gene ID" value="HMPREF0994_04433"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.4841"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGN35743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="224" mass="26137" checksum="70C74750F3ED2297" modified="2011-09-21" version="1">MYKILFVDDDAALRNVVYQYFKERQYDIICTASADKAVSYLKSASIDCVILDVNLPDMNGFELCTSIRQFSSIPIIFLSCYTENDDKIKGFLSGADDYVPKPFSLKELELRVNVRILRRYENQPPELLTFGDLIIDTGRLTAICHGVECTFPRLEFDILSFFAHHPNQLFTYEQLYDNIWKQPINESRHNLQARIGKVRKKLCDICPEKEYIRTIRHKGYLFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KF95</accession>
    <name>F7KF95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_04469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04469"/>
    <dbReference type="EnsemblBacteria" id="EGN35779">
        <property type="protein sequence ID" value="EGN35779"/>
        <property type="gene ID" value="HMPREF0994_04469"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2898471_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN35779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="62" mass="6998" checksum="D76A2369E1280A17" modified="2011-09-21" version="1">MTVLTGILTAPPPAERERHQAGHAAQIRQRHKRTGNSNLGDRDNEYCFKIIVDIIGVVIKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7KFL2</accession>
    <name>F7KFL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_04641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254542.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04641"/>
    <dbReference type="EnsemblBacteria" id="EGN35088">
        <property type="protein sequence ID" value="EGN35088"/>
        <property type="gene ID" value="HMPREF0994_04641"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5069"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN35088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="338" mass="37143" checksum="E557D4FA8418627E" modified="2011-09-21" version="1">MAQDKRNKVPLIEVENMKKYYPIKGGIITHTTGYVKAVDGVSFSVMEGETLGLVGESGCGKSTIGRQIVGLENPTEGKIYYDGKDLAACKPGEMKKIRTQLQMVFQDSYSSLNPRKHIYEILSQPMLYHHISTPATVSKDVDRILDMVGLSRNVLGRYPHEFSGGQRQRIGIAKALSLNPRFLVCDEPVSALDVSIQAQILNLLRQLQKELHLTSLFVGHGLGAVNYVSDRIAVMYLGKIVEIGPATEVFHTPVHPYTKALIQAVPVADPDRAGEERNILQGEIGSSTNPPSGCRFHPRCPYAVESCSREEPEMVETAPGSGHMAACPVVMRKEEVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7KG71</accession>
    <name>F7KG71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3324 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_04854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EGN34481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254755.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_04854"/>
    <dbReference type="EnsemblBacteria" id="EGN34481">
        <property type="protein sequence ID" value="EGN34481"/>
        <property type="gene ID" value="HMPREF0994_04854"/>
    </dbReference>
    <dbReference type="GeneID" id="29727730"/>
    <dbReference type="eggNOG" id="COG4072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051987_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021759">
        <property type="entry name" value="DUF3324_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11797">
        <property type="entry name" value="DUF3324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3324" evidence="2">
        <location>
            <begin position="174"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN34481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="386" mass="41787" checksum="84B60C0855F2F326" modified="2011-09-21" version="1">MFLKKLQKKILARLLFIMVMIVLMPLGIVPALRAQAAAGQTDGIGYYVRAVLPDNQISNNLSYFDLRMQPGQSQTLEVEVVNESDKVITVDLAAVSASTNRNGIIDYKTPDIRDETLKIPFSEIAAPEDTSIVIEAHSTAMARITIDMPAEVYDGVVLGGLVFTQRPEDNAPAEGVTLQNIYSYVLGVKLSETDVDVQPGFELVSVEAGTVNYRPAMIHFIRNKEAAIAKGVDLHIVVRDESGRIAGEFTRRGVDMAPNSVMPLGVTPISGNSGTDSASENIAPFTHGTENAGGDIPQLKPGNYESEITLDYEGESWSFLQPFTVGSVQADELNTALPGAAAHPSSEGSWMMALLIGTGILVLILLMIILLLVRREKDRQTYPMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGR4</accession>
    <name>F7KGR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron(III) transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254944.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05043"/>
    <dbReference type="EnsemblBacteria" id="EGN33752">
        <property type="protein sequence ID" value="EGN33752"/>
        <property type="gene ID" value="HMPREF0994_05043"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5509"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072053_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003364025" evidence="1">
        <location>
            <begin position="30"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="330" mass="35352" checksum="E7DDF958837D30ED" modified="2011-09-21" version="1">MKKCKRLAAVGLAAAVALCTFTGCGKSAADEKVIIYSNADDEAVTAMKNALDNNGFRDQYIFQSFGTSELGGKLLAEGSNIEADLITMSTFYINSAQEQNKMFKSLTFPVNTLDEFPSYCAPITAQEGAIILNTEMMKENNLPVPASIKDLANPEYAGMISVTDINSSSTAWLLIQALVSEYGEDGAKEVLTGIYANAGDHIEDSGSAPLKKARAGEVAIGFGLRHQAVADKASGLPIDFVDPAEGNFSLTESAAVVDKGTQSNPKAMEMAECIINNGRAELQATYPIPLYEGEAEDTENKSGNPRVFGETLTFELLKKHQELSDSCKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGU6</accession>
    <name>F7KGU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009254976.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05075"/>
    <dbReference type="EnsemblBacteria" id="EGN33108">
        <property type="protein sequence ID" value="EGN33108"/>
        <property type="gene ID" value="HMPREF0994_05075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5543"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="168" mass="19282" checksum="110BA2A12E5C92CB" modified="2011-09-21" version="1">MDFILEEWKEDHIAGVAKYANNEKIAGRLRDSFPYPYTKEDAQWFVGDCMEKEGKTQLSRAIVVDGEAVGSIAVMLKDDVYCKSAELGYWLGEPFWRKGIMTRAVQQMCEEAFRRYKLVRIYAEPFSTNLASRGVLEKAGFQLEGIKRKSIFKNGCIQDSYLYAVIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGX1</accession>
    <name>F7KGX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NitT/TauT family transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255001.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05100"/>
    <dbReference type="EnsemblBacteria" id="EGN33133">
        <property type="protein sequence ID" value="EGN33133"/>
        <property type="gene ID" value="HMPREF0994_05100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5573"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="263" mass="29033" checksum="116AAD3F7F186AF8" modified="2011-09-21" version="1">MKRDKGDFRLRKEISQRRFILSAILTFIIIFAGWWALCASGNVRELFLPSPIKVIGDIAAGAKNGSLWVNMGYSIFRITMGFLLSVAIGVPLGILAGSFKPLEAIIAPICEFIRYMPVPAFVPLVMVWCGIGEAAKITIVFLGCFFQLVLMIADDARSVSDDLLSSSYTLGTTRWTTVTKVLIPAMAPKMMLTLRMMIGWGWTYLTVAELVASSSGLGYSILKAQRFLHTESIFSGILVIGILGLITDRLFAFAIKKMFPWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F7KGY3</accession>
    <name>F7KGY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_05113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255014.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05113"/>
    <dbReference type="EnsemblBacteria" id="EGN33146">
        <property type="protein sequence ID" value="EGN33146"/>
        <property type="gene ID" value="HMPREF0994_05113"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5588"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_4_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="284"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="556" mass="65117" checksum="807D67DC54CB14F7" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KH98</accession>
    <name>F7KH98_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002576934.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05237"/>
    <dbReference type="EnsemblBacteria" id="EGN33270">
        <property type="protein sequence ID" value="EGN33270"/>
        <property type="gene ID" value="HMPREF0994_05237"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5719"/>
    <dbReference type="eggNOG" id="ENOG5032UXD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2681276_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="77" mass="8881" checksum="D498D9AABFEAFC1A" modified="2011-09-21" version="1">MNSEQITAFLQEHWYIASVLIGAVILIGAIRNWNWLCDPTGTRDAHRHSRGYRRVVFFLLGVLLIVVSIWGFVLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHF1</accession>
    <name>F7KHF1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255123.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05280"/>
    <dbReference type="EnsemblBacteria" id="EGN33015">
        <property type="protein sequence ID" value="EGN33015"/>
        <property type="gene ID" value="HMPREF0994_05280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5765"/>
    <dbReference type="eggNOG" id="ENOG5031RC2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104971_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="88"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="159" mass="17838" checksum="FC0547A3FFEBCC2B" modified="2011-09-21" version="1">MEVEFDVKIDSAVLYDYMLHHTYTSFAGVVGTTVGALILVAFGMTGHVVYLIAGLIILLYQPGSLLLKAKQQALTNPAFKQPLHYKMTEEGVEVSQGDMVEFQKWEDMVKAISTGRSIILYTTRINASIFPRRDLKDSLSKVVEMISTHMPPKKVNIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHJ8</accession>
    <name>F7KHJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN33062">
        <property type="protein sequence ID" value="EGN33062"/>
        <property type="gene ID" value="HMPREF0994_05327"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5819"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066200_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="35780" checksum="E9E5280EF41591EE" modified="2011-09-21" version="1">MKEKTWLYRVLSAAGSKTQYDEYVKRILGSRQVLARILKGAVPEYSRYSIDEIIQWIEPDIEIADTPPQPGGKNNFDTRITGENTESKIPGEGTINYDIRFRAFLPGNNETEKIKLLLNVEAQKNFYLKYHIVTRGIFYGARMLSEQLNSEFTDSDYDELKKVCSIWICMNSPLHIGNAMSEYRISKQDIIGYIPEQKRCYDKLSVIIICLNETDGKDLRGSLHGFLNTLLSPYMDINKKEEILTRDYGMIMEYELEKELRQMCNLSEAIEENAIYLVKKVLSFSAEGMSDAEIAEICGITEEKVQKILEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHM4</accession>
    <name>F7KHM4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05353"/>
    <dbReference type="EnsemblBacteria" id="EGN32794">
        <property type="protein sequence ID" value="EGN32794"/>
        <property type="gene ID" value="HMPREF0994_05353"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5850"/>
    <dbReference type="eggNOG" id="COG3594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047004_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="372" mass="43200" checksum="F30E868A2D7A7605" modified="2011-09-21" version="1">MEQKVGDTHMLAAGTNRRNYQMDNLKCLLIFSVVFGHMLELFMGKNSPERVIYLVIYSFHMPLFAFVSGVFARYNPSKIKNNMIYPYLIFQTLYLLFSNQILDKDADMQYTTPYWLLWYLFAIIVWNLVLPLVQVEGMKKKMAMLLAAAAASVFIGFDEKAGYFLSASRIVEFFPYFLLGVYYRDMKRKAQETASGLRKEKEQPDYQADKRKKWLFKGAAILILGIILGAFVWLIGQNVEDIKSAWFYGSVSYEKGNYGWQFRLLSIAAALLWLAFFLLCMPVRKIPFLSYIGANTMPVYLLHGFVIKLLSKIKFFSFIEHEEAVALLFSVLLVAVFSWKPLVEFLAPLFRWNRQDFDRRGRKKIGKRVNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHP1</accession>
    <name>F7KHP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255213.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05370"/>
    <dbReference type="EnsemblBacteria" id="EGN32811">
        <property type="protein sequence ID" value="EGN32811"/>
        <property type="gene ID" value="HMPREF0994_05370"/>
    </dbReference>
    <dbReference type="GeneID" id="29727833"/>
    <dbReference type="eggNOG" id="ENOG503281F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2859890_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="65" mass="7438" checksum="285BE916E4F7744B" modified="2011-09-21" version="1">MAKKELTADAKIKNWEKKMSKKLDFLIVGIFFLIFAATAVLQELEAKGITVGTLKDRLKDKRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHS4</accession>
    <name>F7KHS4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05413"/>
    <dbReference type="EnsemblBacteria" id="EGN32854">
        <property type="protein sequence ID" value="EGN32854"/>
        <property type="gene ID" value="HMPREF0994_05413"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.5916"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_8_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN32854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="262" mass="29411" checksum="18FA18AC6197B98C" modified="2011-09-21" version="1">MKLGCCLNMLGDKNDAVGRRYIGTLKEAGYDYMELPLAQIMELSETSFSELAEEAEKTGLPCECCNNFFPASVRLTGETVDPAKVQEYVKRAIDRAVKLGSRVIVFGSSGAKNVPEGFPYDRAFGQIADALRMIDIYAASAGIHIAIEPLNRQESNIIQNLEEGKKLMTEAGGPSIRLLADYYHFMLEKEPLETLKKRIPDIVHVHFADPDGRSFPTESHKEYEDFFAVLKEGGYDGRVSIEAYSENREKEISEAVFLRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KHW0</accession>
    <name>F7KHW0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma-W factor RsiW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN32890.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360088.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05449"/>
    <dbReference type="EnsemblBacteria" id="EGN32890">
        <property type="protein sequence ID" value="EGN32890"/>
        <property type="gene ID" value="HMPREF0994_05449"/>
    </dbReference>
    <dbReference type="GeneID" id="29728050"/>
    <dbReference type="eggNOG" id="ENOG5033I9R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560238_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32890.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="172" mass="20239" checksum="0F3D508F0A8EA554" modified="2013-09-18" version="2">MRNETSCSIIRDLLPNYAEGLTSPETSEVVKAHLETCHTCRSLYEDYQKPVDIPQPEEIKTDKKLIRKIWYQSMWYLFWPCLYAVFLKAGWEKQALTVFGTFAAVVFTALFTYPAYDIYFDDEKKKEYYSREEKHLKRGNGNWFVRNLIWLLPILIPILVEGISQLIVLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIH8</accession>
    <name>F7KIH8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_05657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255464.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05657"/>
    <dbReference type="EnsemblBacteria" id="EGN32281">
        <property type="protein sequence ID" value="EGN32281"/>
        <property type="gene ID" value="HMPREF0994_05657"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6182"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_21_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="351"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="589"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="727"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN32281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="854" mass="94567" checksum="4ED10C8A0CE1C7B0" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIJ8</accession>
    <name>F7KIJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN32166">
        <property type="protein sequence ID" value="EGN32166"/>
        <property type="gene ID" value="HMPREF0994_05677"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2423181_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="91" mass="10327" checksum="FD72861B99441D63" modified="2011-09-21" version="1">MYKQLIFENEVLTAYTHHLMAPEHVHVNCEFVLVTNGTALNTVDGVYPLASYLYTVVVKRDLSLLSIDEIKLLSVVDDRTIRCAQIFISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIK0</accession>
    <name>F7KIK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255486.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05679"/>
    <dbReference type="EnsemblBacteria" id="EGN32168">
        <property type="protein sequence ID" value="EGN32168"/>
        <property type="gene ID" value="HMPREF0994_05679"/>
    </dbReference>
    <dbReference type="GeneID" id="29728146"/>
    <dbReference type="eggNOG" id="ENOG5032CRH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188748_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="233" mass="27173" checksum="E68840BD1165B77B" modified="2011-09-21" version="1">MIERNKARITSIILILLITGYNCLNTENTKDIVKDSNSSMNNQNMVISEQKETEQEEQEENVGKIDKGNLSIPIDYDFLEENYGVYVENICTNPQSIFENSVVLSLVKDDLDYEKYMRSKLPEIPEEDHDYFVFDFNGDGVDDYLVCFHGILWSGSGGNLIRMYVEENGEFVERLSVTAEIFIEDPHKHAEIAVLNERVDGYYSIVLPWTYNRVWSYDREKGRYDSYKYADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIK1</accession>
    <name>F7KIK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05680"/>
    <dbReference type="EnsemblBacteria" id="EGN32169">
        <property type="protein sequence ID" value="EGN32169"/>
        <property type="gene ID" value="HMPREF0994_05680"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547242_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="498" mass="59001" checksum="7103A505A6373A69" modified="2011-09-21" version="1">MKKSYICIVIIVFVCFCVFAYSLEYSNKYKNSRMAEDKSIEEASTEDKTETEEYSNCPFTEEELEQTLKTVIEDDIWFKDKASIFYHCINQKVEYEYKYTEFGYSDGGYVTILPLIEPNNNLSLYYIISLEVYNGKLRDGVSYSGMQNLEEVRSLFIPEATGVGAVNIGERRRPPYDADAEDIEQAKENILRWLDTRSHIGGGPNIEDVYIRNFYKISIETIMFYTYEGERYCRSVYLSGQEGDKPVFVDSMDSDYVDRMLECSFPLEEVPTLDEETEQTLKRMIEEKTEQTLKTAIEDDIWFGYERSIFYPYINQDVQYEYYYEYYYREEHGYIRVLPLIKPDSQSLYYILGFRIDDNILNHISYYSGENLDELKAEHNMPEILGRGTVSIGERREPPYDADEADIEEAKENIRKELEKERKIGSWMQEAPDNDDEIYIKNFYKDSIDTVMLYTYKGEQYYIDIYLDGRRNTTPNAVEEAQKEYYNRMLKECFPLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIN3</accession>
    <name>F7KIN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-glycero-alpha-D-manno-heptose-7-phosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_05713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255520.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05713"/>
    <dbReference type="EnsemblBacteria" id="EGN32202">
        <property type="protein sequence ID" value="EGN32202"/>
        <property type="gene ID" value="HMPREF0994_05713"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6244"/>
    <dbReference type="eggNOG" id="COG2605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048558_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="Galkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014606">
        <property type="entry name" value="Heptose_7-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036406">
        <property type="entry name" value="Hept_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="89"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN32202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="358" mass="41206" checksum="8AD3A504F67B1822" modified="2011-09-21" version="1">MIITKTPFRMSFFGGGTDFSEFFKEYGGSVLSTTFDKYCYVTVRHLPRFFEYTSEICYSQIERVNFISEVQHPMIREAMRELDIHEIRLTYEADLPKHSGLGTSSSFAVGMLNAFHLIKGQYRDKKALADEAIYLERGLCKEVGGLQDQIASSFGGLNKITFDSTGYRVDPVIVYPIRKRKLNSNLMLFFTGFARFSFDIQVSTRKCLKDKIQDLLEMKSLTEEAEKILVNPERDLNDFGRLLDYSWKLKRSLNKDISTEKIDEIYEKAKKAGALGGKVLGAGGGGFILFYAELDKQAAVRYALNDLLYVPFRFEEQGTSVIYYVPETYVPQGEKRVIEDDVWYDDYSNKWEKAEIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIP4</accession>
    <name>F7KIP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,5-diketo-D-gluconate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EGN32218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255536.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05729"/>
    <dbReference type="EnsemblBacteria" id="EGN32218">
        <property type="protein sequence ID" value="EGN32218"/>
        <property type="gene ID" value="HMPREF0994_05729"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6265"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN32218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="283" mass="31779" checksum="B0F5DFB8DD24623C" modified="2011-09-21" version="1">MNSLTDCYKLSNGVEIPCIGFGTWQTPDGDVCVSSVLSAIEAGYRHIDTAQGYGNEESVGHAVKKSGIDRKDLFITSKLTNSEHGYERTLAAFEETMKKLDMDYLDLYLIHWPNPIAFRDHWQEANAGTWKAFEELYKAGRIRAIGISNFRPHHIEELMKTATVAPMVNQIRLCPGETQDEVVDYCRSHNIQLEAYSPLGVGKIFEVPEMKALAEKYGKSIAQICIRWSLQRGYLPLPKSVTPSRIKENTQVFDFELEAADVQLIADLKGCVGYSSDPDTTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7KIY4</accession>
    <name>F7KIY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_05813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255589.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05813"/>
    <dbReference type="EnsemblBacteria" id="EGN31889">
        <property type="protein sequence ID" value="EGN31889"/>
        <property type="gene ID" value="HMPREF0994_05813"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6357"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="161" mass="17711" checksum="B4146ED9B364B19C" modified="2011-09-21" version="1">MAEGKVYIYGGKGHGKSPAAIGCGLIAAAKGARVVIIQFLKGKGLTEDEYPRRLEPGIKLFRFEKSNEDFVALPREKQEEEVQNIRNGLNFAKKVLSTGECDMLILDEVLGLVDNHIITIADLKNVLDMRDGETDIIMTGISLEDDVCALADYVSEIRTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ52</accession>
    <name>F7KJ52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HMPREF0994_05884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255660.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05884"/>
    <dbReference type="EnsemblBacteria" id="EGN31512">
        <property type="protein sequence ID" value="EGN31512"/>
        <property type="gene ID" value="HMPREF0994_05884"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6437"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGN31512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="231" mass="26558" checksum="BFC259609C76654B" modified="2011-09-21" version="1">MAIQKISRDSISDQVFVQMKEQILEGEWKPGEKIPSENELARQFGVSRVTVRNALQKLSALELLETRFGEGSFVRSPDAASVMSPLIPAAYLNDNGMEEILQLRRMIEGPVCGEACRSASEEDVKELESLFQKMEATKDYLPEFARFDYLFHIKMARIAGNSIIMRIYDIMNEVMKSSFEKVVQARGNRAGLYYHGQIVDAFERKDDEAAEKIMDEHMKELYESFFNDFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ68</accession>
    <name>F7KJ68_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR_Cas6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_05900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000015">
        <property type="protein sequence ID" value="EGN31528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255676.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05900"/>
    <dbReference type="EnsemblBacteria" id="EGN31528">
        <property type="protein sequence ID" value="EGN31528"/>
        <property type="gene ID" value="HMPREF0994_05900"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050021_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="168"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="293" mass="33846" checksum="D87DB8DD0203D6F9" modified="2011-09-21" version="1">MGKNEGSFFLNYLPISITLVSLERAELPPFLGSALRGVIGQALFQDKNAYNYLYHNGKMSSNMQDIINPYVLIPPDTKKQIYFEKEELNFKILLLGEGVQYARQLVNAIQQIGKLGLGASRYKFELKKITHSLDQRIIWEKGHFYEIAIRSAALPYHCLPDVSQLHIQMLTPLRIRRNGNLLEELDFTTIIRNIARRIEMITERYGGWCDQLEIGRILELSEDVSVIRQKTEILNMERYSNRLGKKMDFSGLVGDIWFEGDLTPFVPWLHAAQIVHFGRNTTFGMGRTKMEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJ75</accession>
    <name>F7KJ75_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pre-crRNA processing endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_05907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000016">
        <property type="protein sequence ID" value="EGN31535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255683.1">
        <property type="nucleotide sequence ID" value="NZ_KE150408.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_05907"/>
    <dbReference type="EnsemblBacteria" id="EGN31535">
        <property type="protein sequence ID" value="EGN31535"/>
        <property type="gene ID" value="HMPREF0994_05907"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6465"/>
    <dbReference type="eggNOG" id="ENOG502Z82V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086014_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010155">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029950">
        <property type="entry name" value="Cas_CT1134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01876">
        <property type="entry name" value="cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="219" mass="25427" checksum="5DE3B0A873E4F1E1" modified="2011-09-21" version="1">MSHGVKVRVWGELALFSRPEMKVERCSYDVMTPSAARGILEAIYWHPGMCWEVDKIYVRKPIRFTSVRRNEVKSKVLASNVLTVMNGGEKPLYISSKEEIVQRAAILLREVEYVIEAHFEMTERAAAGDNPGKFKDIIMRRLRKGECYHMPYFGCREFPANFALFDEDEIDTAYPGEVRDLGYMLYDFDYSNPDDIQPMFFRAKLENGVLDVRDCEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJN1</accession>
    <name>F7KJN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00153 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_06066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255842.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06066"/>
    <dbReference type="EnsemblBacteria" id="EGN31420">
        <property type="protein sequence ID" value="EGN31420"/>
        <property type="gene ID" value="HMPREF0994_06066"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6643"/>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086031_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN31420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="207" mass="24099" checksum="4517CEBA83BD1B8A" modified="2011-09-21" version="1">MARKNENNYFKMFAEAVSYSCTAADMLKEDFTDFDPSRLAVRIEEMHHIEHTADIAKHELMEKLMKEFITPIDREDILELSNALDDVTDSLEDVLLQLYMFGIISLREDSLTFAAIINDCCHALKKLMLEFENFRKSKVIKDMIIEINHLEENGDRLYTEAMHRLYTKTPDTLEVLSWTTIYNCMEKCCDKCEDAADVVEAVILKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F7KJP4</accession>
    <name>F7KJP4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HGSNAT_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_06083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EGN31437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009255859.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06083"/>
    <dbReference type="EnsemblBacteria" id="EGN31437">
        <property type="protein sequence ID" value="EGN31437"/>
        <property type="gene ID" value="HMPREF0994_06083"/>
    </dbReference>
    <dbReference type="GeneID" id="29723571"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6661"/>
    <dbReference type="eggNOG" id="COG3503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067755_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HGSNAT_cat" evidence="2">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN31437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="252" mass="28713" checksum="0514CFF598A790D5" modified="2011-09-21" version="1">MNARSRYSVLDLVRGLTLISMIAYHGTYDLVYLFSIKIPWFHGEPGYLWQQSICWTFIFLSGMCFSLGRHPVKRGLILTGCGLIITLVTVLVMPESIVIMGVLNFFGFATLITAFLQPLLRRIPAYAGIPVSFLLFLLTREVPSGYLGFEGLRLAALPRFLYQGKLMMVLGFPYDGFYSTDYFSVIPWLFLFLTGYYFWKLLECADSSFPSFLRRSLCRPLELIGRNTLPVYMLHQPALMAVFTALDLIGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKD6</accession>
    <accession>F7K2C2</accession>
    <accession>F7KLS2</accession>
    <name>F7KKD6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00001</name>
        <name evidence="2" type="ORF">HMPREF0994_06315</name>
        <name evidence="3" type="ORF">HMPREF0994_06801</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN30174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACTP02000021">
        <property type="protein sequence ID" value="EGN46311.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48234.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00001"/>
    <dbReference type="EnsemblBacteria" id="EGN30174">
        <property type="protein sequence ID" value="EGN30174"/>
        <property type="gene ID" value="HMPREF0994_06315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN46311">
        <property type="protein sequence ID" value="EGN46311"/>
        <property type="gene ID" value="HMPREF0994_06801"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EGN48234">
        <property type="protein sequence ID" value="EGN48234"/>
        <property type="gene ID" value="HMPREF0994_00001"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6918"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_14_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN30174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN46311.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN48234.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="599" mass="70488" checksum="59145B5C096E6898" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7KKF9</accession>
    <name>F7KKF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unsaturated rhamnogalacturonyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_06338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000009">
        <property type="protein sequence ID" value="EGN47946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256100.1">
        <property type="nucleotide sequence ID" value="NZ_KE150406.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06338"/>
    <dbReference type="EnsemblBacteria" id="EGN47946">
        <property type="protein sequence ID" value="EGN47946"/>
        <property type="gene ID" value="HMPREF0994_06338"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.6941"/>
    <dbReference type="eggNOG" id="COG4225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043688_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN47946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="350" mass="39660" checksum="1DA800F1318191DF" modified="2011-09-21" version="1">MLKLDFDRNQIEDAIDRIVHKTMNMDLTWDWPCGVAYYGISKAWEVTKKEEYLTLLKDRIDEYMELGLPPQWTVNTCAMGHCLITLYEATGDEKYWNVVMSKVHYLQEDALRFGDHVLQHTVSANNDFPEQAWADTLFMAAFFLLRVGVKLNNAEMIDDALNQYYWHIHYLQNPETGLYYHGYNNITGGHMSGFYWGRANAWAAYTMSQVGNILPEAYLYPKYLEVTGSLNEQLAALKLLQTENGLWRTILDDEGSYEEVSASAGIAAAMLEKGNPLHSKYINKAVKGILENVGKDGKVMNVSAGTAVMKDRDGYRDISRRWIQGWGQGLTLAFFSGLLTANDAAKDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLD7</accession>
    <name>F7KLD7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPF0122 protein HMPREF0994_06666</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_06666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0122 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN46590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256419.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06666"/>
    <dbReference type="EnsemblBacteria" id="EGN46590">
        <property type="protein sequence ID" value="EGN46590"/>
        <property type="gene ID" value="HMPREF0994_06666"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.7289"/>
    <dbReference type="eggNOG" id="COG2739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129218_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00245">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007394">
        <property type="entry name" value="UPF0122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40083">
        <property type="entry name" value="PTHR40083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04297">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN46590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="104" mass="12281" checksum="7EB8AA9BFDACCC22" modified="2011-09-21" version="1">MEKIVEQGLLYDFYGELLTEHQRHIYEDVVMNDMSLSEIAQEAGISRQGVHDLIKRCDKTLEEYESKLHLMERFRNIKEKLEQIKLLSSEEAVKKLADDILEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLM6</accession>
    <name>F7KLM6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-mann_mid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_06755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009256508.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06755"/>
    <dbReference type="EnsemblBacteria" id="EGN46347">
        <property type="protein sequence ID" value="EGN46347"/>
        <property type="gene ID" value="HMPREF0994_06755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="268"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN46347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="822" mass="93616" checksum="F4752A31962E4F88" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7KLQ0</accession>
    <name>F7KLQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="7" type="ORF">HMPREF0994_06779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ACTP02000008">
        <property type="protein sequence ID" value="EGN46371.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360040.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_06779"/>
    <dbReference type="EnsemblBacteria" id="EGN46371">
        <property type="protein sequence ID" value="EGN46371"/>
        <property type="gene ID" value="HMPREF0994_06779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="97"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="103"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="194"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN46371.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="349" mass="39526" checksum="4779B8869385D514" modified="2013-09-18" version="2">MNITEYGYIPDGKPFQDGETPARVTAVYKDRYEIICSYGTGLAALKKSSYYTGEESFPTTGDFVLINWEPEGDSRIIRTLKRKTFFARLDPSSAGHWEQLVAANFDYVFIMQSLNHDFNPRRLERYLTLAWQSGARPVVVLTKADLEEDYMQKLQEAAAIARTVDVIAVSAKTGYGLEYLQPYMEPGKTIVFLGSSGVGKSSLVNALAGQDMMAVNSIREDDSKGRHTTTHRQLIMLPCGAMIIDTPGMRELGMWDVTDGLGETFSDVEQYFTQCRFSDCRHQNEPGCRVKAALENGELSQERWKSYLKLKKEARYSASREVYLKNQQMKAKGRARTEKQKRKNSGAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>S2KRP4</accession>
    <name>S2KRP4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_M56 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_07268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000012">
        <property type="protein sequence ID" value="EPC05119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016360249.1">
        <property type="nucleotide sequence ID" value="NZ_KE150407.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07268"/>
    <dbReference type="EnsemblBacteria" id="EPC05119">
        <property type="protein sequence ID" value="EPC05119"/>
        <property type="gene ID" value="HMPREF0994_07268"/>
    </dbReference>
    <dbReference type="GeneID" id="29728256"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389704_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="3">
        <location>
            <begin position="151"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EPC05119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="816" mass="92407" checksum="55D82E3A1E768F2F" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>S2KS97</accession>
    <name>S2KS97_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HMPREF0994_07002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359787.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07002"/>
    <dbReference type="EnsemblBacteria" id="EPC05334">
        <property type="protein sequence ID" value="EPC05334"/>
        <property type="gene ID" value="HMPREF0994_07002"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="431"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="669"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="811"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EPC05334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="934" mass="105796" checksum="2DD1577219801D45" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSP8</accession>
    <name>S2KSP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000003">
        <property type="protein sequence ID" value="EPC05272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05272">
        <property type="protein sequence ID" value="EPC05272"/>
        <property type="gene ID" value="HMPREF0994_07080"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2488636_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="87" mass="9844" checksum="F643B2B484863ED9" modified="2013-09-18" version="1" fragment="single">RKEKEESLERDYGMKMEYELGEELSEMCNLSEAIEENAIKKGKKQGLREGILLTKKVIKLSAEGMSEAKVAQTCGITPEEVHEILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>S2KSQ8</accession>
    <name>S2KSQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_07077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000002">
        <property type="protein sequence ID" value="EPC05282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05282">
        <property type="protein sequence ID" value="EPC05282"/>
        <property type="gene ID" value="HMPREF0994_07077"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2437043_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EPC05282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="90" mass="10339" checksum="4D048EC6AC50A765" modified="2013-09-18" version="1">MIKMGIYFFNDEELNQVLLVFVDTIYSYDTKQKKFFGGTDKYMTEKEYQNFRPITELNSESEVEKEPKPIISSLLQAGAAQGRKQDGGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>S2KVW4</accession>
    <name>S2KVW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_07200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000011">
        <property type="protein sequence ID" value="EPC05145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07200"/>
    <dbReference type="EnsemblBacteria" id="EPC05145">
        <property type="protein sequence ID" value="EPC05145"/>
        <property type="gene ID" value="HMPREF0994_07200"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EPC05145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="174" mass="19387" checksum="3BC04AA4495ACD01" modified="2013-09-18" version="1">MVVTFLSPSTGLINNILARFGMERVNFLTEPSYFWIIYTIMTIWQTAGYSAIIYLASLTGISSELYEAARIDGAGRWAQLLHITLPGLTPTIVLLFLMKIGRVLDVGYETIVLMYNPSIYSTADVIGTYVYRRGILNGEYSFASAVGFFQSVIGLLLVLFANRVAKKTSETSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAY1</accession>
    <name>S2LAY1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_07029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359835.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="EPC05361">
        <property type="protein sequence ID" value="EPC05361"/>
        <property type="gene ID" value="HMPREF0994_07029"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046274_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="238"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EPC05361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="429" mass="48893" checksum="0C41472F4C4E2CF2" modified="2013-09-18" version="1">MNNKHLTFDDRLAIQAGLQQGLKVAQIAKNIGKDRATVGREIKAHRKLVATSKGNSCVRHDTCTKVPECRQGCFRGKRQCQTACGGCNSGCPEYQEEFCSGYEKSPFVCNACGNRLRCRLRRMLYDAKHAQEQYEKIRSESRRGISLTEEELVRINDTISPLIKQGQSIPAICGMYRDELPVTDRTIYSYIDAGILDARNIDLRRKLRRPERKKSGPVLRVDKKCHMGRAYGDYQAYMAQNPDAMVSQMDSVVIHKGGQAILTVLFTTCDLQLMFLRDRNTAASVTEIFKKLRGQLGGERFQALFQVILTDRGSEFTDPTRIEADTETGEIQCRVFYCEPMNSNQKSNCERNHEFIRYVIPKGQARDRYAEEEIREMMNHINSYPRKKWNGQAPIDLFKKIYGEETATLLGLEKIPSASITLTPALFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-09-18" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>S2LAZ8</accession>
    <name>S2LAZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="13" type="ORF">HMPREF0994_07049</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EPC05381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016359871.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_07049"/>
    <dbReference type="EnsemblBacteria" id="EPC05381">
        <property type="protein sequence ID" value="EPC05381"/>
        <property type="gene ID" value="HMPREF0994_07049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="264"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EPC05381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="656" mass="75645" checksum="20C0E9ED3182D4EC" modified="2013-09-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2F5</accession>
    <name>F7K2F5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009249983.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00034"/>
    <dbReference type="EnsemblBacteria" id="EGN48267">
        <property type="protein sequence ID" value="EGN48267"/>
        <property type="gene ID" value="HMPREF0994_00034"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.37"/>
    <dbReference type="eggNOG" id="ENOG502ZCC2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1538124_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="174" mass="19780" checksum="852511487A262952" modified="2011-09-21" version="1">MLIEKIPIVPEIMRIDTRTQAIDMQQIGNRRFLFNPKTGVLVLGRQYQETSLVNASHAVELADAGITKDFDDFVRGWIGTGRNYPKGVIHFAPCVDSGNISLFDRAFDTLEMFRENGALAGTVVRGFGSRWEQPLSAILTDLQKEEQKPSLRQQLRKTPEGKAVRHRKENQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F7K2Q3</accession>
    <name>F7K2Q3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250081.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00132"/>
    <dbReference type="EnsemblBacteria" id="EGN42749">
        <property type="protein sequence ID" value="EGN42749"/>
        <property type="gene ID" value="HMPREF0994_00132"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.140"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_6_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="422"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="517"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="638" mass="72066" checksum="A9D818920F08BC9A" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7K396</accession>
    <name>F7K396_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250275.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00326"/>
    <dbReference type="EnsemblBacteria" id="EGN33467">
        <property type="protein sequence ID" value="EGN33467"/>
        <property type="gene ID" value="HMPREF0994_00326"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.350"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_17_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="151" mass="17547" checksum="4F5FD58249D29062" modified="2011-09-21" version="1">MDRSEKTVLTNMCMIYDDDGNVLVQDRRDSDWGGITFPGGHVEKGESFTDAVIREVYEETGLTIETPQICGIKQWPEDDGSRYIVLFYKTSHFAGELKSSEEGEVYWTKLSRLKDLPLARGMELMLRVFLEDEVSEYYIYEEDGEWKHVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3A8</accession>
    <name>F7K3A8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250290.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00341"/>
    <dbReference type="EnsemblBacteria" id="EGN33482">
        <property type="protein sequence ID" value="EGN33482"/>
        <property type="gene ID" value="HMPREF0994_00341"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.368"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_29_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN33482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="219" mass="25351" checksum="2BA39FACDE700CD9" modified="2011-09-21" version="1">MARNKYPEETRNLIIDTAARLFVEKGYEHTSIQDIINNLGGLSKGAIYHHFKSKDEIMNAVADKLYAGATESMWVIARRKDLTGLEKLRMIFQTSMYSSAQEELFSAAPDMMNNPQLLVLYLRNSVQKESPAMIQPILEEGIADGSIRTEYPRELAEVLMLIGNLWLNPMVYPCDTEQLLNKLKFFQHMLRVFGLDIIEDEMFTQLEKYSQLYQENKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3M3</accession>
    <name>F7K3M3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HMPREF0994_00452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN31967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250401.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00452"/>
    <dbReference type="EnsemblBacteria" id="EGN31967">
        <property type="protein sequence ID" value="EGN31967"/>
        <property type="gene ID" value="HMPREF0994_00452"/>
    </dbReference>
    <dbReference type="GeneID" id="29726378"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363481" description="SBP_bac_5 domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="112"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGN31967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="558" mass="61022" checksum="9639ADD38C07460C" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K3R7</accession>
    <name>F7K3R7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN48214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00496"/>
    <dbReference type="EnsemblBacteria" id="EGN48214">
        <property type="protein sequence ID" value="EGN48214"/>
        <property type="gene ID" value="HMPREF0994_00496"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166021_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN48214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="114" mass="13274" checksum="86F05FAFAAA8B351" modified="2011-09-21" version="1">MYQYFSKQAKELIQFYRVVLEIPFIKTDVDESNGVYLGFIENAPTLCIWDCEIFNVQPTGHQSFVFQTDNLDLTMECLKKKGVALSDAIRYDWGTYEVRLNDIDGNEIVIVEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F7K430</accession>
    <name>F7K430_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Flagellar M-ring protein FliF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HMPREF0994_00621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250570.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00621"/>
    <dbReference type="EnsemblBacteria" id="EGN44809">
        <property type="protein sequence ID" value="EGN44809"/>
        <property type="gene ID" value="HMPREF0994_00621"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.674"/>
    <dbReference type="eggNOG" id="COG1766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028108_2_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="10">
        <location>
            <begin position="44"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="11">
        <location>
            <begin position="253"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGN44809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="533" mass="57031" checksum="E3F9E30131CCF636" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F7K486</accession>
    <name>F7K486_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250627.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00678"/>
    <dbReference type="EnsemblBacteria" id="EGN44866">
        <property type="protein sequence ID" value="EGN44866"/>
        <property type="gene ID" value="HMPREF0994_00678"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.734"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN44866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="33781" checksum="1F377A9E51546CFE" modified="2011-09-21" version="1">MKKIRKVMTRKNGFILAFLLPGILLFGIIYAYPLVNIFMTSFCKWNYKNFLKPEFLGWGHLFDNYIKLFTADRNFQMALVNSLKWVALTMLVQIPFTLLVALILAKKPLGWKFTRNAFIIPNIISTAAIGLIFLNLYSPSRGIVTEICNWIRPGSDISVLANETYAFWGVTFSFILFGGSSCLLLLTQIFSIDTSLLEAARVDGASAGQIDRKIILPLLRPMLGTVSVMAANYGLLLYNEIALITGGGPDNATYSLSYYVYKTALGSTKLNFARGNTAGVIQFLLGLLLVGMINRAFRTDYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7K499</accession>
    <name>F7K499_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HMPREF0994_00607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 5">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250556.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00607"/>
    <dbReference type="EnsemblBacteria" id="EGN44795">
        <property type="protein sequence ID" value="EGN44795"/>
        <property type="gene ID" value="HMPREF0994_00607"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.660"/>
    <dbReference type="eggNOG" id="COG1558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123272_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGN44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="145" mass="15819" checksum="75A11A5D54B2B7E6" modified="2011-09-21" version="1">MSFINSLNISASGMSAQKLRLDVAAENIANQETTRTENGGPYRRKMVVLQAAEDNSFRKAMDFASSQARPAGVRAVQIADDATQLNPVYDPTHPDADANGYVQMPNVDLVKETIDSMSATRSYDANITAFNAMKLMMQKALEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4K2</accession>
    <name>F7K4K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple sugar transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_00781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00781"/>
    <dbReference type="EnsemblBacteria" id="EGN43490">
        <property type="protein sequence ID" value="EGN43490"/>
        <property type="gene ID" value="HMPREF0994_00781"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.848"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="303" mass="34347" checksum="CCF383366B73F308" modified="2011-09-21" version="1">MNKGKTEKIKKSYSDRVFDIVNIIIMLALLVIFLWPLWFVVIASFSNPNEVWNGNVILLPKGFTLSAYEAVSQYKMIWTGYKNTIIYTVVGTFINLVMTICAAYPLSRKDFVPRNFLMFIFMLTMYFSGGLIPTYLVVSKMHLLNTPWAMMIPGAVSIYNVIITRTYFVNSIPSSLQEAAELDGANTFQFLMKIVLPLSKPIIAVIALYYAVGHWNDFFTALIYLNDKELMPLQSFLRDLLMSNKMSLNNMQGLDAAQAEAKMQLSQTLKYSAIIVSTVPVLCIYPFIQKYFVKGVMIGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4S1</accession>
    <name>F7K4S1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250799.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00850"/>
    <dbReference type="EnsemblBacteria" id="EGN43402">
        <property type="protein sequence ID" value="EGN43402"/>
        <property type="gene ID" value="HMPREF0994_00850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.928"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027560_0_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="345"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="420" mass="46364" checksum="5FE9A3B23C84D2DF" modified="2011-09-21" version="1">MAKKLHAAQTTDSPYAGGLKISITSTLGQIPIEGATVSIALTESPDVILDTLTTDASGQTDVVELPAPPLDYSLSPSEQRPYSEYNITVEAPGYEPVVVEGSEILPDVLSLQPVALIPEAVPGQEEDIVIPDHTLYGDYPPKIPEAEIKPVDETGEIVLSRVVIPEYVVVHDGVPTDSSAPNYYVRYTDYIKNVASSEIYATWPESTIYANILAIMSFTLNRVYTEWYRNQGYNFTITSSTAFDQKWIYGRNIYENISYLVDTIFANYLSRPGVRQPILTSYCDGRRVNCSGLSQWGSKYLGDEGYSAMEIIHYYYGSDMYINTADAISGIPSSWPGYTLTIGSSGAKVLQMQEQLNRISQNYPAIPYVAADGVYGQQTADAVKVFQRVFGLPQTGAVDYPTWYEISRIFVGVSRIAEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4U0</accession>
    <name>F7K4U0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250818.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00869"/>
    <dbReference type="EnsemblBacteria" id="EGN43178">
        <property type="protein sequence ID" value="EGN43178"/>
        <property type="gene ID" value="HMPREF0994_00869"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.947"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="112" mass="12687" checksum="090A428E71480BB4" modified="2011-09-21" version="1">MSVDKTLLSGSTSMLLLKLLEEKDLYGYEMIESLRARSNNVFELKAGTLYPLLHSLEEKGFLTSYEKEIGGKTRKYYSITEAGKKHLIQKKKEWNEYSQAVAGILTFSAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4W1</accession>
    <name>F7K4W1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250839.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00890"/>
    <dbReference type="EnsemblBacteria" id="EGN43199">
        <property type="protein sequence ID" value="EGN43199"/>
        <property type="gene ID" value="HMPREF0994_00890"/>
    </dbReference>
    <dbReference type="GeneID" id="29725382"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.972"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003363512" evidence="2">
        <location>
            <begin position="29"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="556" mass="62026" checksum="460BF9CFD8A1B109" modified="2011-09-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K4Z7</accession>
    <name>F7K4Z7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1653 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250877.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00928"/>
    <dbReference type="EnsemblBacteria" id="EGN43237">
        <property type="protein sequence ID" value="EGN43237"/>
        <property type="gene ID" value="HMPREF0994_00928"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1015"/>
    <dbReference type="eggNOG" id="COG4728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097488_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1653" evidence="2">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="190" mass="22174" checksum="E706593DA9B46AB4" modified="2011-09-21" version="1">MERTPRPNEIYQHFKGNLYKVITLATHSETGESMVVYQALYGDFQVFVRPLEMFVSKVDHDKYPQVKAEYRFTLVPQILGQGAPEEEPLPSEPEEEKGMNGDSFRQEENLWMEEEEAVLDPLLMKFLDADTYEDKLNILVGLQSRITDDMLNTIAVSLDLELEEGELEERYQTLKNCLITLEKYECNRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F7K500</accession>
    <name>F7K500_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_00933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43242.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00933"/>
    <dbReference type="EnsemblBacteria" id="EGN43242">
        <property type="protein sequence ID" value="EGN43242"/>
        <property type="gene ID" value="HMPREF0994_00933"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048266_2_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGN43242.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="124" mass="14149" checksum="64FE94E066790522" modified="2013-09-18" version="2">MGLKSFSGDFPVLKDIGVAKNYLDDKELKVLNNIVSGYFDFAEVQAMRHNPMYMADYVEHLDRVLRSTGEEVLQGAGKISHAQAIEKATREYKKFQVQNLSPIEKEYLESIGNMYNAVKKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F7K530</accession>
    <name>F7K530_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250917.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00968"/>
    <dbReference type="EnsemblBacteria" id="EGN43277">
        <property type="protein sequence ID" value="EGN43277"/>
        <property type="gene ID" value="HMPREF0994_00968"/>
    </dbReference>
    <dbReference type="GeneID" id="29725967"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1058"/>
    <dbReference type="eggNOG" id="ENOG502ZB3X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603803_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046098">
        <property type="entry name" value="DUF6034"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19499">
        <property type="entry name" value="DUF6034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356643" evidence="2">
        <location>
            <begin position="29"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="487" mass="54484" checksum="8B5E9BC8F5B7E86C" modified="2011-09-21" version="1">MWKKRWVAAAAIMSMVLTVPIGCQGTSAGSENPSAGSKDSSQEDLVVPKNQESTVPAQTAKGGNIAEQVQAPDAFELQFSDESGKIEVEVKARVVVPEADGFRLKTVTSRIFTQEDYDAVNRVLLQGGRLWDRVVDENDPAHGFTKSEIEERIRILKEEKESGESYVDQYGDGKDYDKKIAEFEAMLEAAPETAQIEEIEPKVQFDTKAEENGNPYGNALMGYVTMDGKDYFTVLDNNISPTWRWIYFSTEYSGEGGNYMPVGMEGDNAAHLKTSPAEIEQRAAAAVEEMGLTDFQPCGGEYFASFTEEKGQMVPVDYSYGVHFTRVIDGIPVTYTNNDGTTVEDDNASWPYEHIYLAYNDEGLTSFRWTDPYTVTDMSDEYVFLMPFEEIQKIFKEMILKKYNDLAQAGLDLSFHIEEIRLGYMRIMEKGNPTEGTMVPVWDFLGTKVIDHNNTGEAYTDSFGGPYESCLTINAMDGTVIDRDLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K537</accession>
    <name>F7K537_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_00975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250924.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00975"/>
    <dbReference type="EnsemblBacteria" id="EGN43284">
        <property type="protein sequence ID" value="EGN43284"/>
        <property type="gene ID" value="HMPREF0994_00975"/>
    </dbReference>
    <dbReference type="GeneID" id="29725438"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003357090" evidence="2">
        <location>
            <begin position="26"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN43284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="445" mass="49724" checksum="EC8FEF4ACD94215C" modified="2011-09-21" version="1">MRGKKWTVLVLLSAMFLWSIAGCKASESRSDIPETVPSEESPETDGGGEEKPFAGVTLTLLNFSSATPGGVLTDTCAAAEEKFGFHIEIEPCYDDNVVRTRLAIGDCPDLLVYNTGSLLYSLAPSEFFLDLTDTKMAEKLDSDFIRAASVDGVLYGIPQCDSMCAGVFYNKELYEAYGLEVPETWEDFRKNLEVLQHAGMDGMGISLSELVSSQLPFLADNYQVMYENPDFAQEFTFGETGFADSQEGLRTWERYEELVPYLNEDCATVSNTEIEERFFDNRVGHLIQFSSRIPEWMNTYGEEINKIGFFALPGDTKEATGLTIWPSNGIYGNKKSENTEAILAFMEWYVSEEGQDVMTSFYSPAGVFHTGYQPKEKSIELVQEVQKYYTEGNIMLALEYLTPIKGINCAQICNKLGSGRISALEAAEAYDEECRKMALQIGLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K549</accession>
    <name>F7K549_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TdcF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_00987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250936.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_00987"/>
    <dbReference type="EnsemblBacteria" id="EGN43296">
        <property type="protein sequence ID" value="EGN43296"/>
        <property type="gene ID" value="HMPREF0994_00987"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1078"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN43296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="125" mass="13222" checksum="1C4A521CE314AE78" modified="2011-09-21" version="1">MLKKIATDKAPAAIGPYSQAIAAGDFLFASGQIPINPENGNIEAEGIVAQAEQVMKNIGAILEAAGTDYAKVVKTSCFLADMADFAAFNGVYEKYFTEKPARSCVAVKELPKSVLCEVEVIAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7K577</accession>
    <name>F7K577_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HMPREF0994_01015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000001">
        <property type="protein sequence ID" value="EGN43324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009250964.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01015"/>
    <dbReference type="EnsemblBacteria" id="EGN43324">
        <property type="protein sequence ID" value="EGN43324"/>
        <property type="gene ID" value="HMPREF0994_01015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1108"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGN43324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="230" mass="25754" checksum="1D6D5C7F6514F54A" modified="2011-09-21" version="1">MENKIKVLIAEDLEPIRVKYAYYLGQCPEIELTGSVSSGTEAVSAALASPPDIILMDIEMETKDAGIRASREILASLPDIKIIILTVYEDDELIFSAFQLGVCDYMLKNSSNEEIISGIKAAYEGRSPIRPEIAGKIRSEFKRVKTYETSFLYMLNLLASLTVTELDTLYLLSSGHTRADICAIRHVEMSTVKSQIHSILHKFKKKSISEIITSTEDLHLLELVIKNRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5Q8</accession>
    <name>F7K5Q8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251136.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01187"/>
    <dbReference type="EnsemblBacteria" id="EGN42588">
        <property type="protein sequence ID" value="EGN42588"/>
        <property type="gene ID" value="HMPREF0994_01187"/>
    </dbReference>
    <dbReference type="GeneID" id="29724708"/>
    <dbReference type="eggNOG" id="ENOG50326V7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169482_0_0_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003356657" evidence="1">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="237" mass="25643" checksum="27EA18B94B98725A" modified="2011-09-21" version="1">MFKKITGLVLGIALFTMCPLTAAAAPMVPAPYTADQLVDLSRAALAGVSSYHVDSVESTEFTYPATPQANFSYVETSQLTATPSCIYYQVVESVTTGGSTETKTVERYTSFEGNTLKEYTHNNNLPWGFRSRPVTQKGVTSFSMPDSFSLLKKNSGQAAIPVYTDGVVYQFTEQASKGSSSLVYTFDAASLLLISIHAEFPGTPANNINRMEYVITYNMYDNLAVPAEIVSAAIPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5X5</accession>
    <name>F7K5X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251203.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01254"/>
    <dbReference type="EnsemblBacteria" id="EGN42454">
        <property type="protein sequence ID" value="EGN42454"/>
        <property type="gene ID" value="HMPREF0994_01254"/>
    </dbReference>
    <dbReference type="GeneID" id="29725251"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1371"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021676_3_1_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="321"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="452" mass="49067" checksum="CE09A9BA13FCF07C" modified="2011-09-21" version="1">MKSLGIDIGTTSICLVCYEEGREKLLFTASRQNEFLPGTFEQDPEAIVEKVKDMLAEAEENGFGSGAVDTMDSSAADAIESSIVDSIGISSQMHGILYVDADGCAVSPFYTWKDEKGRELMEDGRSYEACLSQSLGMPVFSGFGTVTHFCLSRKGLIPGRAVKLANIGDYVAMCLTGRKSPLTDESIAASFGGYDVQEGNFAWEKLEQAGVDISYYPELCRRGEAAGTYRGIPVSCAFGDNQASFYGALDKPETQISVNVGTGSQVSLFDSRYYRTAAADIRPYFHKGCLYVGASLNGGKVYEKLAAFFEEIVYEFTGQNIQAFDQMARLGAEKKETGLMITPSLYGKRGEAGSGADAYGTMRNLTADDFHASDFIRAYVKGMADELYRMYLEFPEEIRRGRTEIVASGNGIRKNPLMAEETAKVFGLPVIFKDTQEEAAAGAAKAALDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F7K5Y7</accession>
    <name>F7K5Y7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HMPREF0994_01266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251215.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01266"/>
    <dbReference type="EnsemblBacteria" id="EGN42379">
        <property type="protein sequence ID" value="EGN42379"/>
        <property type="gene ID" value="HMPREF0994_01266"/>
    </dbReference>
    <dbReference type="GeneID" id="29724466"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_2_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGN42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="245" mass="28615" checksum="FFBE578AE3532EDC" modified="2011-09-21" version="1">MVLGLYCRDDLLAREIEETVLSLRMGAGCEEKPVRGMDYELRRLASLPGAAEDMAEGDGGFFLILAGEKPEDAIAAAERLWLERPFLSVIYVASQAEDVFSALPYPFYHLVRRFALEQDLGAVFKKMERSRPPVQRWHTFLCKNELVRVCQKDILYLESERHEIRIHCRDEIMTTTEPLSQCEERLKDGGFARIHKSFLVSLYHVNRMERDSLTLDNGEKLYISRYRYPEVKLQFESYIRHLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F7K631</accession>
    <name>F7K631_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HMPREF0994_01310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000004">
        <property type="protein sequence ID" value="EGN42172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251259.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01310"/>
    <dbReference type="EnsemblBacteria" id="EGN42172">
        <property type="protein sequence ID" value="EGN42172"/>
        <property type="gene ID" value="HMPREF0994_01310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1432"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_3_9"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGN42172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="311" mass="36019" checksum="D4D3004B0CF18FBF" modified="2011-09-21" version="1">MDKIAVLIPCYNEEKTIEKVVSDAKQALPEAVIYVYDNNSKDRTVELARKAGAVIRYERKQGKGNVIRRMFREIDALCYIMIDGDDTYPLEYAREMADKVLLENSDMVVGDRLSSTYYQENKRPFHNMGNSLVKSSINLLFNSEIQDIMTGYRAFSYQFVKSFPVLSKGFEIETEMSIHAVYNNMQVDNVIVNYRDRPEGSESKLNTYSDGIRVLGTILKMFRQYKPLAYFTLLAVFLTVLSAVFFVPVLWEFWETGMVDKFPTLIVCGFVELAAIQSIFAGLILHNLGVKERRDFEMQLNNIRERFERIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6N7</accession>
    <name>F7K6N7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ALGX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HMPREF0994_01547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009251496.1">
        <property type="nucleotide sequence ID" value="NZ_KE150405.1"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01547"/>
    <dbReference type="EnsemblBacteria" id="EGN42021">
        <property type="protein sequence ID" value="EGN42021"/>
        <property type="gene ID" value="HMPREF0994_01547"/>
    </dbReference>
    <dbReference type="GeneID" id="29724851"/>
    <dbReference type="PATRIC" id="fig|658086.3.peg.1687"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045959_1_0_9"/>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000003336">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031811">
        <property type="entry name" value="ALGX/ALGJ_SGNH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16822">
        <property type="entry name" value="ALGX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0016">Alginate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="ALGX" evidence="5">
        <location>
            <begin position="93"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGN42021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000003336"/>
        </source>
    </evidence>
    <sequence length="366" mass="42466" checksum="14476E5708880431" modified="2011-09-21" version="1">MTKKKAAAWIIVFALLVIGPGIIYHFAEPYINMENTENRQLAEKPVLSRDNLQTFASEYNSYYNDHLAFRSQMIEANSILSMNVFRDSSSSSVVLGKNNWLFFTDEGSIEDYKGTNLYTRDQLELIKDNILSTKAYLEARGIEFILMIPSNKEEIYSDNLPDYIRKRGEQTRAEQVISYLREETGIRIVYPKEELMAYKDQYDLYWHYDTHWNYLGAYIGAKALLQELGIQVPQVEELTITPNDFSGYDLANMMNLRDYYKKNKPAEVSYDVTGYPTNNLAVIQAIDATELIYQSDSPDRRRLFLVRDSFAGGMAPVLASNFAYTYMPHWNGCFEQSMIDEQQPDIFVYEVVERRLDALLSFRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-09-21" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F7K6U6</accession>
    <name>F7K6U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HMPREF0994_01613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lachnospiraceae bacterium 3_1_57FAA_CT1</name>
        <dbReference type="NCBI Taxonomy" id="658086"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-05" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Brown A."/>
                <person name="Chapman S.B."/>
                <person name="Chen Z."/>
                <person name="Dunbar C."/>
                <person name="Freedman E."/>
                <person name="Gearin G."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larson L."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="Mehta T."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="submission" date="2013-04" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.</title>
            <authorList>
                <consortium name="The Broad Institute Genomics Platform"/>
                <person name="Earl A."/>
                <person name="Ward D."/>
                <person name="Feldgarden M."/>
                <person name="Gevers D."/>
                <person name="Daigneault M."/>
                <person name="Strauss J."/>
                <person name="Allen-Vercoe E."/>
                <person name="Walker B."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Allen A.W."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Gainer-Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Ireland A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Poon T.W."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">3_1_57FAA_CT1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ACTP02000005">
        <property type="protein sequence ID" value="EGN42087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="658086.HMPREF0994_01613